Phd in MORPHOGENESIS AND TISSUE ENGINEERING

email: elena.vicini@uniroma1.it
phone: +390649766757
building: RM008 palazzina 39
room: 29C

CURRENT RESEARCH INTERESTS
Regulation of testicular function in mammals, Regulation of spermatogonial proliferation and differentiation, Spermatogonial stem cell niche, Influence of environmental pollution on reproduction.
TEACHING RESPONSABILITIES
Lectures and courses in Histology and Medical Embryology to medical students, “Sapienza” University of Rome, Rome, Italy.
Lectures in Histology for students “Tecnico di Laboratorio biomedico”, University of Rome "La Sapienza", Rome, Italy.
Member of the committee of the PhD school “Morphogenesis, homeostasis and Tissues Engineering” “Sapienza” University of Rome, Rome, Italy
REVIEWER ACTIVITIES
Biology of Reproduction, Human Reproduction, Reproduction, Developmental Biology, Reproductive Toxicology, Reproductive Bio Medicine Online, European Research Funding Organizations.
RESEARCH GRANTS
Italian Ministry of Education ( Ateneo, Facoltà, COFIN), Italian Agency of Space, Paster Institute- Fondazione Cenci-Bolognetti
MEMBERSHIP OF SCIENTIFIC SOCIETIES
Member of the Permanent Scientific Committee of the European Testis Workshops
WORK EXPERIENCE
2013 to date Associate Professor of Histology and Embryology “Sapienza” University of Rome, Rome, Italy
2000-2013 Researcher “Sapienza” University of Rome, Rome, Italy
2001 Visiting scientist Department of Cell Biology, Utrecht Medical Center, Utrecht, Holland
1995-2000 Postdoctoral fellow “Sapienza” University of Rome, Rome, Italy
1993-94 Visiting scholar Division of Reproductive Biology, Department of Gynecology and Obstetrics, Stanford University, USA.
EDUCATION AND TRAINING
1994 PhD in “Morphogenetic and cytological sciences”. “Sapienza” University of Rome, Rome, Italy.
1990 B.S. degree, “Sapienza” University of Rome, Rome, Italy.







SELECTED PUBLICATION (last 15 years)
Taggi M, Capponi C, Bertani N, Saturno G, Innocenti F, Dovere L, Fabozzi SM, Alesiani O, Arena V, Cimadomo D, Mazzilli R, Rienzi L, Ubaldi FM, Canipari R, Vicini E, Apa R. Role of thyroid stimulating hormone in the maintenance and functioning of the human corpus luteum. J Endocrinol Invest. 2024 Jan 8;. doi: 10.1007/s40618-023-02269-z. [Epub ahead of print] PubMed PMID: 38190029.
Lazzaretti C, Roy N, Paradiso E, Capponi C, Ferrari T, Reggianini F, Sperduti S, Perri C, Baschieri L, Mascolo E, Varani M, Canu G, Trenti T, Nicoli A, Morini D, Iannotti F, Villani MT, Vicini E, Simoni M, Casarini L. Benzo[a]pyrene disrupts LH/hCG-dependent mouse Leydig cell steroidogenesis through receptor/Gαs protein targeting. Sci Rep. 2024 Jan 8;14(1):844. doi: 10.1038/s41598-024-51516-7. PubMed PMID: 38191651.
Capponi C, Vicini E (2023). Current Understanding of the Physiology and Histology of Human Spermatogenesis. In “Men’s Reproductive and Sexual Health Throughout the Lifespan. An Integrated Approach to Fertility, Sexual Function, and Vitality” (pp 23-33). Cambridge University Press
Capponi C, Palazzoli M, Di Persio S, Fera S, Spadetta G, Franco G, Wistuba, J, Schlatt, S, Neuhaus N, de Rooij D, Vicini E. Interplay of spermatogonial subpopulations during initial stages of spermatogenesis in adult primates. Development 2023 150(10): dev201430. doi: 10.1242/dev.201430. Epub 2023 May 24.
Innocenti F, Di Persio S, Taggi, M, Maggio R, Lardo P, Toscano V, Canipari, R, Vicini E, Stigliano A. Effect of Mitotane on Male Gonadal Function, Cancers, 2023 15(12):3234.
Roy N, Lazzaretti C, Paradiso E, Capponi C, Ferrari T, Reggianini F, Sperduti S, Baschieri L, Mascolo E, Perri C, Varani M, Canu G, Trenti T, Nicoli A, Morini D, Iannotti F, Villani M, Vicini E, Simoni M, Casarini L . Short-term exposure to bisphenol a does not impact gonadal cell steroidogenesis in vitro. Cells, 2023 12(11):1537.
Campolo F, Capponi C, Tarsitano MG, Tenuta M, Pozza C, Gianfrilli D, Magliocca F, Venneri MA, Vicini E, Lenzi A, Isidori AM, Barbagallo F. cAMP-specific phosphodiesterase 8A and 8B isoforms are differentially expressed in human testis and Leydig cell tumor. Front Endocrinol (Lausanne). 2022 Oct 7;13:1010924. doi: 10.3389/fendo.2022.1010924
Taggi M, Kovacevic A, Capponi C, Falcinelli M, Cacciamani V, Vicini E, Canipari R, Tata AM. The activation of M2 muscarinic receptor inhibits cell growth and survival in human epithelial ovarian carcinoma. J Cell Biochem. 2022 Sep;123(9):1440-1453. doi: 10.1002/jcb.30303.
Saracino R, Capponi C, Di Persio S, Boitani C, Masciarelli S, Fazi F, Fera S, Vicini E.(2020) Regulation of Gdnf expression by retinoic acid in Sertoli cells. Mol Reprod Dev. 2020 Feb 5. doi: 10.1002/mrd.23323.
Ntemou, Elissavet, Kadam, Prashant, Van Laere, Sven, Van Saen, Dorien, Vicini, Elena, Goossens, Ellen (2019). Effect of recombinant human vascular endothelial growth factor on testis tissue xenotransplants from prepubertal boys: a three-case study. REPRODUCTIVE BIOMEDICINE ONLINE, pii: S1472-6483(19)30238-X.
Sohni A, Tan K, Song HW, Burow D, de Rooij DG, Laurent L, Hsieh TC, Rabah R, Hammoud SS, Vicini E, Wilkinson MF (2019). The Neonatal and Adult Human Testis Defined at the Single-Cell Level. Cell Rep. 5;26(6):1501-1517.
Naro C, Jolly A, Di Persio S, Bielli P, Setterblad N, Alberdi AJ, Vicini E, Geremia R, De la Grange P, Sette C. An Orchestrated Intron Retention Program in Meiosis Controls Timely Usage of Transcripts during Germ Cell Differentiation. Dev Cell. 2017 Apr 10;41(1):82-93.e4
Antinozzi C, Marampon F, Corinaldesi C, Vicini E, Sgrò P, Vannelli G B, Lenzi A, Crescioli C, Di Luigi L (2017). Testosterone insulin-like effects: an in vitro study on the short-term metabolic effects of testosterone in human skeletal muscle cells. JOURNAL OF ENDOCRINOLOGICAL INVESTIGATION, 40(10):1133-1143.
Di Persio S, Saracino R, Fera S, Muciaccia B, Esposito V, Boitani C, Berloco BP, Nudo F, Spadetta G, Stefanini M, de Rooij DG, Vicini E (2017). Spermatogonial kinetics in humans. Development. 2017 Oct 1;144(19):3430-3439.
Boitani C, Di Persio S, Esposito V, Vicini E. (2016) Spermatogonial cells: mouse, monkey and man comparison. Semin Cell Dev Biol. 2016 Mar 5. pii: S1084-9521(16)30068-4.
Lamberti D., Vicini E. (2014). Promoter analysis of the gene encoding GDNF in murine Sertoli cells. Molecular and Cellular Endocrinology 394 (105-114).
Lisa Dovere, Stefania Fera, Margherita Grasso, Dante Lamberti, Cesare Gargioli, Barbara Muciaccia, Anna Maria Lustri, Mario Stefanini, Elena Vicini (2013) The Niche-Derived Glial Cell Line-Derived Neurotrophic Factor (GDNF) Induces Migration of Mouse Spermatogonial Stem/Progenitor Cells PLoS ONE 8(4): e59431. doi:10.1371/journal.pone.0059431
Cecchi R, Sestili C, Prosperini G, Cecchetto G, Vicini E, Viel G, Muciaccia B. (2014) Markers of mechanical asphyxia: immunohistochemical study on autoptic lung tissues. Int J Legal Med. 128(1):117-25. doi: 10.1007/s00414-013-0876-x. Epub 2013 May 29.
B. Muciaccia, C. Boitani, B. P. Berloco, F. Nudo, G. Spadetta, M. Stefanini, D.G. de Rooij, E. Vicini (2013). Novel stage classification of human spermatogenesis based on acrosome development. BIOLOGY OF REPRODUCTION, 89(3):60, 1–10 ISSN: 0006-3363.
Ferranti F, Muciaccia B, Ricci G, Dovere L, Canipari R, Magliocca F, Stefanini M, Catizone A, Vicini E. (2012) Glial cell line- derived neurotrophic factor promotes invasive behaviour in testicular seminoma cells. Int J Androl. 2012 Oct;35(5):758-68. doi: 10.1111/j.1365-2605.2012.01267.x. [Epub ahead of print]
Margherita Grasso, Andrea Fuso, Lisa Dovere, Dirk G. de Rooij, Mario Stefanini,Carla Boitani and Elena Vicini (2011). Distribution of GFRA1-expressing spermatogonia in adult mouse testis. Reproduction, 143(3):325-32.
Scaldaferri ML, Fera S, Grisanti L, Sanchez M, Stefanini M, De Felici M, Vicini E. (2011). Identification of side population cells in mouse primordial germ cells and prenatal testis. The international Journal of Developmental Biology, 55:209-14
Grisanti L, Falciatori I, Grasso M, Dovere L, Fera S, Muciaccia B, Fuso A, Berno V, Boitani C, Stefanini M, Vicini E. (2009). Identification of Spermatogonial Stem Cell Subsets by Morphological Analysis and Prospective Isolation. Stem Cells, vol. 27; p. 3043-3052.
Grisanti L, Corallini S, Fera S, Muciaccia B, Stefanini M, Witke W, Vicini E (2009). Inactivation of Numb and Numblike in spermatogonial stem cells by cell-permeant Cre recombinase. Differentiation, vol. 78; p. 131-136, IF 3,3. doi: 10.1016/j.diff. 2009.05.0518)