EMANUELE CACCI

Professore associato

email: emanuele.cacci@uniroma1.it
telefono: 06 4991 2206
edificio: CU026 Fisiologia generale
stanza: 314-320

Nome e cognome: Emanuele Cacci
Posizione attuale: Professore associato
Indirizzo: Sapienza, Università di Roma, Dipartimento di Biologia e Biotecnologie "Charles Darwi"n, Piazzale Aldo Moro n. 5, 00185, Roma, Italia
Tel./Fax: +39 06 4991 2206/ +39 06 4991 2351
e-mail: emanuele.cacci@uniroma1.it

Formazione

- 2003 Dottorato di Ricerca in Biologia Cellulare e dello Sviluppo Università di Roma “La Sapienza”
- 1999 Laurea in Biologia con lode Università di Roma “La Sapienza”

Esperienza lavorativa e di ricerca

1997‐1999 Studente laureando Dip. Di Biologia Cellulare e dello Sviluppo, Università di Roma “La Sapienza”
1999-2003 dottorando Dip. di Biologia Cellulare e dello Sviluppo, Università di Roma “La Sapienza”
2003-2006 Post-dottorato nel gruppo diretto dai Professori Olle Lindvall e Zaal kokaia presso l'Ospedale Universitario di Lund (Svezia) presso il Centro Cellule Staminali.
Luglio-Agosto 2015: Visiting scientist, ospitato dal Prof Zaal Kokaia, presso lo Stem Cell Center, ospedale universitario, Lund (Svezia)
Giugno-Luglio: Visiting scientist presso l'Istituto di Scienze e Tecnologia (IST) di Klosterneuburg (Austria) ospitato dalla Prof Gaia Novarino,
Presente: professore associato presso il Dipartimento di Biologia e Biotecnologie “Charles Darwin”, Sapienza, Università di Roma.

Esperienza di insegnamento

2007-2008/2008-2009 lezione su “Metodologie per lo studio del sistema nervoso”
2012- oggi: docente in “Le cellule staminali nel sistema nervoso”
2022-oggi docente in "Analisi Biochimico Cliniche"
2022-oggi: docente in " Biochemical and Molecular Diagnostics"

Campo di ricerca
La mia ricerca è principalmente focalizzata sullo studio: 1) del contributo di specifici fattori estrinseci e intrinseci che controllano le proprietà delle cellule staminali neurali (NSC) 2) degli effetti della neuroinfiammazione, principalmente mediata da microglia e astrociti, sul mantenimento e sulla differenziazione delle cellule staminali neurali (NSC) e sopravvivenza neuronale 3) le proprietà delle NSC e il loro potenziale neurogenico nel cervello di topi adulti in condizioni patologiche (ad esempio disturbi dello spettro autistico) e durante l'invecchiamento.

Pubblicazioni selezionate (ultimi 15 anni)

1. Diamanti T, Trobiani L, Mautone L, Serafini F, Gioia R, Ferrucci L, Lauro C, Bianchi S, Perfetto C, Guglielmo S, Sollazzo R, Giorda E, Setini A, Ragozzino D, Miranda E, Comoletti D, Di Angelantonio S, Cacci E, De Jaco A. Glucocorticoids rescue cell surface trafficking of R451C Neuroligin3 and enhance synapse formation. Traffic. 2024 Jan;25(1):e12930. doi: 10.1111/tra.12930.

2. Giuliani A, Licursi V, Nisi PS, Fiore M, D'Angelo S, Biagioni S, Negri R, Rugg-Gunn PJ, Cacci E, Lupo G. Dbx2, an Aging-Related Homeobox. Stem Cell Rev Rep. 2023 Nov;19(8):2837-2851. doi: 10.1007/s12015-023-10600-7.

3. Gioia R, Seri T, Diamanti T, Fimmanò S, Vitale M, Ahlenius H, Kokaia Z, Tirone F, Micheli L, Biagioni S, Lupo G, Rinaldi A, De Jaco A, Cacci E. Adult hippocampal neurogenesis and social behavioural deficits in the R451C Neuroligin3 mouse model of autism are reverted by the antidepressant fluoxetine. J Neurochem. 2023 May;165(3):318-333. doi: 10.1111/jnc.15753.

4. Quaresima S, Istiaq A, Jono H, Cacci E, Ohta K, Lupo G. Assessing the Role of Ependymal and Vascular Cells as Sources of Extracellular Cues Regulating the Mouse Ventricular-Subventricular Zone Neurogenic Niche. Front Cell Dev Biol. 2022 Apr 5;10:845567. doi: 10.3389/fcell.2022.84556

5. Wang W, Di Nisio E, Licursi V, Cacci E, Lupo G, Kokaia Z, Galanti S, Degan P, D'Angelo S, Castagnola P, Tavella S, Negri R. Simulated Microgravity Modulates Focal Adhesion Gene Expression in Human Neural Stem Progenitor Cells. Life (Basel). 2022 Nov 9;12(11):1827. doi: 10.3390/life12111827.

6. Morandell J, Schwarz LA, Basilico B, Tasciyan S, Dimchev G, Nicolas A, Sommer C, Kreuzinger C, Dotter CP, Knaus LS, Dobler Z, Cacci E, Schur FKM, Danzl JG, Novarino G. Cul3 regulates cytoskeleton protein homeostasis and cell migration during a critical window of brain development. Nat Commun. 2021 May 24;12(1):3058. doi: 10.1038/s41467-021-23123-x. PMID: 34031387

7. Stronati E, Biagioni S, Fiore M, Giorgi M, Poiana G, Toselli C, Cacci E. Wild-Type and Mutant FUS Expression Reduce Proliferation and Neuronal Differentiation Properties of Neural Stem Progenitor Cells. Int J Mol Sci. 2021 Jul 15;22(14):7566. doi: 10.3390/ijms22147566.

8. Poiana G, Gioia R, Sineri S, Cardarelli S, Lupo G, Cacci E. Transcriptional regulation of adult neural stem/progenitor cells: tales from the subventricular zone. Neural Regen Res. 2020 Oct;15(10):1773-1783. doi: 10.4103/1673-5374.280301. Review.

9. Eleonora Stronati, Roberta Conti, Emanuele Cacci, Silvia Cardarelli, Stefano Biagioni, Giancarlo Poiana (2019). Exosome-induced differentiation of neural stem progenitor cells. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, Jul 27;20(15). pii: E3691. doi: 10.3390/ijms20153691

10. Maria Antonietta Ajmone-Cat, Angela Onori, Camilla Toselli, Eleonora Stronati, Mariangela Morlando, Irene Bozzoni, Emanuela Monni, Zaal Kokaia, Giuseppe Lupo, Luisa Minghetti, Stefano Biagioni, Emanuele Cacci (2019). Increased FUS levels in astrocytes leads to astrocyte and microglia activation and neuronal death. SCIENTIFIC REPORTS, vol. 9, p. 1-15, ISSN: 2045-2322, doi: 10.1038/s41598-019-41040-4.

11. Giuseppe Lupo, Roberta Gioia, Paola Serena Nisi, Stefano Biagioni, Emanuele Cacci (2019). Molecular mechanisms of neurogenic aging in the adult mouse subventricular zone. JOURNAL OF EXPERIMENTAL NEUROSCIENCE, vol. 13, p. 1-10, ISSN: 1179-0695

12. Giuseppe Lupo, Silvana Gaetani, Emanuele Cacci, Stefano Biagioni, Rodolfo Negri (2019). Molecular signatures of the aging brain: finding the links between genes and phenotypes. NEUROTHERAPEUTICS, ISSN: 1933-7213, doi: 10.1007/s13311-019-00743-2.

13. Cera Arcangela Anna, Cacci Emanuele, Toselli Camilla, Cardarelli Silvia, Bernardi Alessandra, Gioia Roberta, Giorgi Mauro, Poiana Giancarlo, Biagioni Stefano (2018). Egr1 maintains NSC proliferation and its overexpression counteracts cell cycle exit triggered by the withdrawal of Epidermal Growth Factor. DEVELOPMENTAL NEUROSCIENCE, vol. 40, p. 223-233, ISSN: 0378-5866, doi: 10.1159/000489699.

14. Lupo Giuseppe, Nisi Paola S, Esteve Pilar, Paul Yu-Lee, Novo Clara Lopes, Sidders Ben, Khan, Muhammad A, Biagioni Stefano, Liu Hai-Kun, Bovolenta Paola, Cacci Emanuele*, Rugg-Gunn, Peter J (2018). Molecular profiling of aged neural progenitors identifies Dbx2 as a candidate regulator of age-associated neurogenic decline. AGING CELL, vol. 17, p. 1-15, ISSN: 1474-9718, doi: 10.1111/acel.12745. *corresponding author.

15. Roberto Sacco, Emanuele Cacci, Gaia Novarino (2018). Neural stem cells in neuropsychiatric disorders. CURRENT OPINION IN NEUROBIOLOGY, vol. 48, p. 131-138, ISSN: 0959-4388, doi: 10.1016/j.conb.2017.12.005.

16. Cacci Emanuele, Negri, Rodolfo, Biagioni, Stefano, Lupo, Giuseppe (2017). Histone methylation and microRNA-dependent regulation of epigenetic activities in neural progenitor self-renewal and differentiation. CURRENT TOPICS IN MEDICINAL CHEMISTRY, vol. 17, p. 794-807, ISSN: 1568-0266, doi: 10.2174/1568026616666160414124456.

17. Guglielmi L, Nardella M, Musa C, Iannetti I, Arisi I, D'Onofrio M, Storti A, Valentini A, Cacci Emanuele, Biagioni, S, Augusti Tocco G, D'Agnano I, Felsani A. (2017). Lamin A/C Is Required for ChAT-Dependent Neuroblastoma Differentiation. MOLECULAR NEUROBIOLOGY, vol. 5, p. 3729-3744, ISSN: 0893-7648, doi: 10.1007/s12035-016-9902-6.

18. Guadagno Noemi Antonella, Moriconi Claudia, Licursi Valerio, D'acunto Emanuela, Nisi Paola Serena, Carucci, Nicoletta, De Jaco Antonella, Cacci Emanuele, Negri Rodolfo, Lupo Giuseppe, Miranda Banos Maria Elena (2017). Neuroserpin polymers cause oxidative stress in a neuronal model of the dementia FENIB. NEUROBIOLOGY OF DISEASE, vol. 103, p. 32-44, ISSN: 0969-9961, doi: 10.1016/j.nbd.2017.03.010.

19. Carucci Nicoletta, Cacci Emanuele, Nisi Paola Serena, Licursi Valerio, Paul, Yu Lee, Biagioni Stefano, Negri Rodolfo, Rugg Gunn, Peter J., Lupo, Giuseppe (2017). Transcriptional response of Hoxb genes to retinoid signalling is regionally restricted along the neural tube rostrocaudal axis. ROYAL SOCIETY OPEN SCIENCE, vol. 4, ISSN: 2054-5703, doi: 10.1098/rsos.160913.

20. Soldati C, Caramanica P, Burney MJ, Toselli C, Bithell A, Augusti Tocco G, Stanton LW, Biagioni, S, Buckley NJ, Cacci Emanuele (2015). RE1 silencing transcription factor/neuron-restrictive silencing factor regulates expansion of adult mouse subventricular zone-derived neural stem/progenitor cells in vitro. JOURNAL OF NEUROSCIENCE RESEARCH, vol. 8, p. 1203-1214, ISSN: 1097-4547, doi: 10.1002/jnr.23572.

21. Gioia Ubaldo, Valerio Di Carlo, Pasquale Caramanica, Camilla Toselli, Antonella Cinquino, Marcella Marchioni, Pietro Laneve, Stefano Biagioni, Irene Bozzoni, Emanuele Cacci*, Elisa Caffarelli (2014). miR-23a and miR-125b regulate neural stem/progenitor cell proliferation by targeting Musashi1. RNA BIOLOGY, vol. 11, p. 1105-1112, ISSN: 1547-6286, doi: 10.4161/rna.35508. *corresponding author.

22. Gabriele De Luca, Ilenia Ventura, Valentina Sanghez, Maria Teresa Russo, Maria Antonietta Ajmone Cat, Cacci, Emanuele, Alberto Martire, Patrizia Popoli, Germana Falcone, Flavia Michelini, Marco Crescenzi, Paolo Degan, Luisa Minghetti, Margherita Bignami, Gemma Calamandrei (2013). Prolonged lifespan with enhanced exploratory behavior in mice overexpressing the oxidized nucleoside triphosphatase hMTH1. AGING CELL, vol. 12, p. 695-705, ISSN: 1474-9718, doi: 10.1111/acel.12094.

23. Maddalena Sinno, Stefano Biagioni, Maria Antonietta Ajmone-Cat, Irene Pafumi, Pasquale Caramanica, Virginia Medda, Gaetana Tonti, Luisa Minghetti, Ferdinando Mannello, Emanuele Cacci (2013). The Matrix Metalloproteinase Inhibitor Marimastat Promotes Neural Progenitor Cell Differentiation into Neurons by Gelatinase-Independent TIMP-2-Dependent Mechanisms. STEM CELLS AND DEVELOPMENT, vol. 22, p. 345-358, ISSN: 1547-3287, doi: 10.1089/scd.2012.0299.

24. M.A. Ajmone-Cat, M.L. Salvatori, Roberta De Simone, Melissa Mancini, Stefano Biagioni, Antonietta Bernardo, Emanuele Cacci, Luisa Minghetti (2012). Docosahexaenoic acid modulates inflammatory and antineurogenic functions of activated microglial cells. JOURNAL OF NEUROSCIENCE RESEARCH, vol. 90, p. 575-587, ISSN: 0360-4012, doi: 10.1002/jnr.22783.

25. Chiara Soldati, Emanuele Cacci, Stefano Biagioni, Nicoletta Carucci, Giuseppe Lupo, Carla Perrone-Capano, Isabella Saggio, Gabriella Augusti-Tocco (2012). Restriction of Neural Precursor Ability to Respond to Nurr1 by Early Regional Specification. PLOS ONE, vol. 7, p. e51798-, ISSN: 1932-6203, doi: 10.1371/journal.pone.0051798.

26. Maria Antonietta Ajmone-Cat*, Emanuele Cacci*, Ylenia Ragazzoni, Luisa Minghetti, Stefano Biagioni (2010). Pro-gliogenic effect of IL-1α in the differentiation of embryonic neural precursor cells in vitro. JOURNAL OF NEUROCHEMISTRY, vol. 113, p. 1060-1072, ISSN: 0022-3042, doi: 10.1111/j.1471-4159.2010.06670.x. * gli autori hanno ugualmente contribuito al lavoro.

27. Maria Antonietta Ajmone-Cat, Emanuele Cacci, Luisa Minghetti (2010). Brain inflammation and the neuronal fate: from neurogenesis to neurodegeneration. In: Kenneth Maiese. Neurovascular Medicine: Pursuing Cellular Longevity for Healthy Aging. p. 319-344, Oxford University Press, ISBN: 978-019532669-7, doi: 10.1093/acprof:oso/9780195326697.003.0013

28. Emanuele Cacci, Biagioni Stefano (2009). Colture di cellule staminali neurali come modello per lo studio di patologie del sistema nervoso, studi farmacologici e di neurotossicità. BIOCHIMICA CLINICA, vol. 33, p. 129-136, ISSN: 0393-0564

29. G. Martella, A. Tassone, G. Sciamanna, P. Platania, D. Cuomo, M.T. Viscomi, P. Bonsi, Emanuele Cacci, Stefano Biagioni, A. Usiello, G. Bernardi, N. Sharma, D.G. Standaert, A. Pisani (2009). Impairment of bidirectional synaptic plasticity in the striatum of a mouse model of DYT1 dystonia: role of endogenous acetylcholine. BRAIN, vol. 132, p. 2336-2349, ISSN: 0006-8950, doi: 10.1093/brain/awp194.

30. Gaetana A. Tonti, Ferdinando Mannello, Cacci Emanuele, Biagioni Stefano (2009). Neural stem cells at the crossroads: MMPs may tell the way. THE INTERNATIONAL JOURNAL OF DEVELOPMENTAL BIOLOGY, vol. 53, p. 1-17, ISSN: 0214-6282, doi: 10.1387/ijdb.082573gt

Publication metrics (source: Scopus)

ORCID ID 0000-003-0082-6999
- H-index: 20
- Total publication number: 38
- Total citations: 1811
- Average Citations per Product: 47

Produzione scientifica

11573/1700615 - 2024 - Glucocorticoids rescue cell surface trafficking of R451C Neuroligin3 and enhance synapse formation

Diamanti, T.; Trobiani, L.; Mautone, L.; Serafini, F.; Gioia, R.; Ferrucci, L.; Lauro, C.; Bianchi, S.; Perfetto, C.; Guglielmo, S.; Sollazzo, R.; Giorda, E.; Setini, A.; Ragozzino, D.; Miranda, E.; Comoletti, D.; Di Angelantonio, S.; Cacci, E.; De Jaco, A. - 01a Articolo in rivista

rivista: TRAFFIC (Oxford : Blackwell) pp. 1-22 - issn: 1600-0854 - wos: WOS:001143197700001 (0) - scopus: 2-s2.0-85182499298 (0)

11573/1668215 - 2023 - Adult hippocampal neurogenesis and social behavioural deficits in the R451C Neuroligin3 mouse model of autism are reverted by the antidepressant Fluoxetine

Gioia, Roberta; Seri, Tommaso; Diamanti, Tamara; Fimmanò, Stefania; Vitale, Marina; Ahlenius, Henrik; Kokaia, Zaal; Tirone, Felice; Micheli, Laura; Biagioni, Stefano; Lupo, Giuseppe; Rinaldi, Arianna; De Jaco, Antonella; Cacci, Emanuele - 01a Articolo in rivista

rivista: JOURNAL OF NEUROCHEMISTRY (Editore attuale:BLACKWELL PUBLISHING LTD, 9600 GARSINGTON RD, OXFORD, ENGLAND, OXON, OX4 2DG Lippincott, Williams & Wilkins:530 Walnut Street:Philadelphia, PA 19106:(800)638-3030, (301)223-2300, EMAIL: orders@lww.com, INTERNET: http://www.lww.com, Fax: (301)223-2320, (301)223-2320) pp. - - issn: 0022-3042 - wos: WOS:000911198900001 (11) - scopus: 2-s2.0-85146133893 (11)

11573/1687377 - 2023 - Dbx2, an Aging-Related Homeobox Gene, Inhibits the Proliferation of Adult Neural Progenitors

Giuliani, A.; Licursi, V.; Nisi, P. S.; Fiore, M.; D'angelo, S.; Biagioni, S.; Negri, R.; Rugg-Gunn, P. J.; Cacci, E.; Lupo, G. - 01a Articolo in rivista

rivista: STEM CELL REVIEWS AND REPORTS (New York NY: Springer; New York NY: Humana Press) pp. - - issn: 2629-3277 - wos: WOS:001052536000001 (0) - scopus: 2-s2.0-85168462377 (0)

11573/1651297 - 2022 - Polymerogenic neuroserpin causes mitochondrial alterations and activates NFκB but not the UPR in a neuronal model of neurodegeneration FENIB

D'acunto, E; Gianfrancesco, L; Serangeli, I; D'orsi, M; Sabato, V; Guadagno, N A; Bhosale, G; Caristi, S; Failla, A V; De Jaco, A; Cacci, E; Duchen, M R; Lupo, G; Galliciotti, G; Miranda, E - 01a Articolo in rivista

rivista: CELLULAR AND MOLECULAR LIFE SCIENCES (Birkhaeuser Verlag AG:Viaduktstrasse 42-44, CH 4051 Basel Switzerland:011 41 61 2050707, EMAIL: subscriptions@birkhauser.ch, INTERNET: http://www.birkhauser.ch, Fax: 011 41 61 2050792) pp. - - issn: 1420-682X - wos: WOS:000828696400008 (2) - scopus: 2-s2.0-85134581511 (4)

11573/1630535 - 2022 - Assessing the role of ependymal and vascular cells as sources of extracellular cues regulating the mouse ventricular-subventricular zone neurogenic niche

Quaresima, Sabrina; Istiaq, Arif; Jono, Hirofumi; Cacci, Emanuele; Ohta, Kunimasa; Lupo, Giuseppe - 01a Articolo in rivista

rivista: FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY (Lausanne : Frontiers Media S.A., 2013-) pp. - - issn: 2296-634X - wos: WOS:000791017900001 (15) - scopus: 2-s2.0-85128574414 (13)

11573/1660151 - 2022 - Simulated microgravity modulates focal adhesion gene expression in human neural stem progenitor cells

Wang, Wei; Di Nisio, Elena; Licursi, Valerio; Cacci, Emanuele; Lupo, Giuseppe; Kokaia, Zaal; Galanti, Sergio; Degan, Paolo; D'angelo, Sara; Castagnola, Patrizio; Tavella, Sara; Negri, Rodolfo - 01a Articolo in rivista

rivista: LIFE (Basel: MDPI) pp. - - issn: 2075-1729 - wos: WOS:000884128000001 (2) - scopus: 2-s2.0-85141693372 (2)

11573/1550522 - 2021 - Cul3 regulates cytoskeleton protein homeostasis and cell migration during a critical window of brain development

Morandell, Jasmin; Schwarz, Lena A.; Basilico, Bernadette; Tasciyan, Saren; Dimchev, Georgi; Nicolas, Armel; Sommer, Christoph; Kreuzinger, Caroline; Dotter, Christoph P.; Knaus, Lisa S.; Dobler, Zoe; Cacci, Emanuele; Schur, Florian K. M.; Danzl, Johann G.; Novarino, Gaia - 01a Articolo in rivista

rivista: NATURE COMMUNICATIONS (London: Nature Publishing Group-Springer Nature) pp. 1-22 - issn: 2041-1723 - wos: WOS:000658769900010 (15) - scopus: 2-s2.0-85106657766 (20)

11573/1571821 - 2021 - Wild-Type and Mutant FUS Expression Reduce Proliferation and Neuronal Differentiation Properties of Neural Stem Progenitor Cells

Stronati, Eleonora; Biagioni, Stefano; Fiore, Mario; Giorgi, Mauro; Poiana, Giancarlo; Toselli, Camilla; Cacci, Emanuele - 01a Articolo in rivista

rivista: INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (Basel: MDPI Center) pp. 1-21 - issn: 1422-0067 - wos: WOS:000676983200001 (4) - scopus: 2-s2.0-85110184463 (4)

11573/1383443 - 2020 - X-ray irradiated cultures of mouse cortical neural stem/progenitor cells recover cell viability and proliferation with dose-dependent kinetics

Licursi, Valerio; Anzellotti, Silvia; Favaro, Jessica; Sineri, Serena; Carucci, Nicoletta; Cundari, Enrico; Fiore, Mario; Guarguaglini, Giulia; Pippa, Simone; Nisi, Paola S.; Verni', Fiammetta; Biagioni, Stefano; Cacci, Emanuele; Amendola, Roberto; Lupo, Giuseppe; Negri, Rodolfo - 01a Articolo in rivista

rivista: SCIENTIFIC REPORTS (London: Springer Nature London: Nature Publishing Group) pp. - - issn: 2045-2322 - wos: WOS:000562147700003 (5) - scopus: 2-s2.0-85083477391 (6)

11573/1348015 - 2020 - Transcriptional regulation of adult neural stem/progenitor cells: tales from the subventricular zone

Poiana, Giancarlo; Gioia, Roberta; Sineri, Serena; Cardarelli, Silvia; Lupo, Giuseppe; Cacci, Emanuele - 01a Articolo in rivista

rivista: NEURAL REGENERATION RESEARCH (Shenyang : Publishing House of Neural Regeneration Research.) pp. 1773-1783 - issn: 1673-5374 - wos: WOS:000526946300001 (6) - scopus: 2-s2.0-85089127194 (8)

11573/1347065 - 2019 - Neural stem cell properties and adult hippocampal neurogenesis in a knock-in mice model, expressing an autism-associated mutation.

Gioia, Roberta; Sollazzo, Raimondo; Vitale, Marina; Trobiani, Laura; Di Mattia, Miriam; Biagioni, Stefano; De Jaco, Antonella; Cacci, Emanuele - 04f Poster

congresso: 2019 EUROGENESIS MEETING (Bordeaux)

libro: 2019 EUROGENESIS MEETING - ()

11573/1274398 - 2019 - Molecular signatures of the aging brain: finding the links between genes and phenotypes

Lupo, Giuseppe; Gaetani, Silvana; Cacci, Emanuele; Biagioni, Stefano; Negri, Rodolfo - 01a Articolo in rivista

rivista: NEUROTHERAPEUTICS (Orlando, FL: Elsevier, c2007-) pp. 543-553 - issn: 1933-7213 - wos: WOS:000481434900002 (24) - scopus: 2-s2.0-85067072783 (27)

11573/1235452 - 2019 - Molecular mechanisms of neurogenic aging in the adult mouse subventricular zone

Lupo, Giuseppe; Gioia, Roberta; Nisi, Paola Serena; Biagioni, Stefano; Cacci, Emanuele - 01a Articolo in rivista

rivista: JOURNAL OF EXPERIMENTAL NEUROSCIENCE ([Auckland, N.Z.] : Libertas Academica, [2008]-) pp. 1-10 - issn: 1179-0695 - wos: WOS:000459562600001 (29) - scopus: 2-s2.0-85067016373 (29)

11573/1249111 - 2019 - Increased FUS levels in astrocytes leads to astrocyte and microglia activation and neuronal death

Maria Antonietta Ajmone-Cat, ; Angela, Onori; Toselli, Camilla; Stronati, Eleonora; Morlando, Mariangela; Bozzoni, Irene; Emanuela, Monni; Kokaia, Zaal; Lupo, Giuseppe; Luisa, Minghetti; Biagioni, Stefano; Cacci, Emanuele - 01a Articolo in rivista

rivista: SCIENTIFIC REPORTS (London: Springer Nature London: Nature Publishing Group) pp. 1-15 - issn: 2045-2322 - wos: WOS:000461159600049 (29) - scopus: 2-s2.0-85062953966 (31)

11573/1317843 - 2019 - Extracellular vesicle-induced differentiation of neural stem progenitor cells

Stronati, E.; Conti, R.; Cacci, E.; Cardarelli, S.; Biagioni, S.; Poiana, G. - 01a Articolo in rivista

rivista: INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (Basel (Matthaeustrasse 11) : Molecular Diversity Preservation International MDPI) pp. - - issn: 1661-6596 - wos: WOS:000482383000084 (33) - scopus: 2-s2.0-85070785180 (36)

11573/1117185 - 2018 - Egr1 maintains NSC proliferation and its overexpression counteracts cell cycle exit triggered by the withdrawal of Epidermal Growth Factor

Cera, Arcangela Anna; Cacci, Emanuele; Toselli, Camilla; Cardarelli, Silvia; Bernardi, Alessandra; Gioia, Roberta; Giorgi, Mauro; Poiana, Giancarlo; Biagioni, Stefano - 01a Articolo in rivista

rivista: DEVELOPMENTAL NEUROSCIENCE (S Karger AG:Allschwilerstrasse 10, CH-4009 Basel Switzerland:011 41 61 3061111, EMAIL: orders@karger.ch, INTERNET: http://www.karger.com, Fax: 011 41 61 3061234) pp. 223-233 - issn: 0378-5866 - wos: WOS:000447191700004 (10) - scopus: 2-s2.0-85049896848 (10)

11573/1086094 - 2018 - Molecular profiling of aged neural progenitors identifies Dbx2 as a candidate regulator of age-associated neurogenic decline

Lupo, Giuseppe; Nisi, Paola S; Esteve, Pilar; Paul, Yu-Lee; Novo, Clara Lopes; Sidders, Ben; Khan, Muhammad A; Biagioni, Stefano; Liu, Hai-Kun; Bovolenta, Paola; Cacci, Emanuele; Rugg-Gunn, Peter J - 01a Articolo in rivista

rivista: AGING CELL (-MALDEN:WILEY-BLACKWELL PUBLISHING, INC. -Oxford : Blackwell, 2002-) pp. 1-15 - issn: 1474-9718 - wos: WOS:000431962300012 (26) - scopus: 2-s2.0-85043278965 (26)

11573/1063494 - 2018 - Neural stem cells in neuropsychiatric disorders

Sacco, Roberto; Cacci, Emanuele; Novarino, Gaia - 01a Articolo in rivista

rivista: CURRENT OPINION IN NEUROBIOLOGY (Current Biology Limited:84 Theobalds Road, London WC1X 8RR United Kingdom:011 44 20 76114202, EMAIL: info@biomednet.com, INTERNET: http://www.biomednet.com, Fax: 011 44 20 76114479) pp. 131-138 - issn: 0959-4388 - wos: WOS:000427101600018 (28) - scopus: 2-s2.0-85039148837 (30)

11573/932406 - 2017 - Histone methylation and microRNA-dependent regulation of epigenetic activities in neural progenitor self-renewal and differentiation

Cacci, Emanuele; Negri, Rodolfo; Biagioni, Stefano; Lupo, Giuseppe - 01a Articolo in rivista

rivista: CURRENT TOPICS IN MEDICINAL CHEMISTRY (Hilversum : Bentham Science Publishers) pp. 794-807 - issn: 1568-0266 - wos: WOS:000394569800003 (20) - scopus: 2-s2.0-85011604944 (21)

11573/950767 - 2017 - Transcriptional response of Hoxb genes to retinoid signalling is regionally restricted along the neural tube rostrocaudal axis

Carucci, Nicoletta; Cacci, Emanuele; Nisi, Paola Serena; Licursi, Valerio; Paul, Yu Lee; Biagioni, Stefano; Negri, Rodolfo; Rugg Gunn, Peter J.; Lupo, Giuseppe - 01a Articolo in rivista

rivista: ROYAL SOCIETY OPEN SCIENCE (London : The Royal Society) pp. - - issn: 2054-5703 - wos: WOS:000400527200011 (7) - scopus: 2-s2.0-85017271064 (7)

11573/950793 - 2017 - Neuroserpin polymers cause oxidative stress in a neuronal model of the dementia FENIB

Guadagno, Noemi Antonella; Moriconi, Claudia; Licursi, Valerio; D'acunto, Emanuela; Nisi, Paola Serena; Carucci, Nicoletta; De Jaco, Antonella; Cacci, Emanuele; Negri, Rodolfo; Lupo, Giuseppe; Miranda Banos, Maria Elena - 01a Articolo in rivista

rivista: NEUROBIOLOGY OF DISEASE (Academic Press Incorporated:6277 Sea Harbor Drive:Orlando, FL 32887:(800)543-9534, (407)345-4100, EMAIL: ap@acad.com, INTERNET: http://www.idealibrary.com, Fax: (407)352-3445) pp. 32-44 - issn: 0969-9961 - wos: WOS:000401683200004 (22) - scopus: 2-s2.0-85016948857 (23)

11573/950855 - 2017 - Lamin A/C Is Required for ChAT-Dependent Neuroblastoma Differentiation

Guglielmi, L; Nardella, M; Musa, C; Iannetti, I; Arisi, I; D'onofrio, M; Storti, A; Valentini, A; Cacci, Emanuele; Biagioni, Stefano; Augusti Tocco, G; D'agnano, I; Felsani, A. - 01a Articolo in rivista

rivista: MOLECULAR NEUROBIOLOGY (Humana Press Incorporated:999 Riverview Drive, Suite 208:Totowa, NJ 07512:(973)256-1699, EMAIL: lglasner@humanapr.com, INTERNET: http://www.humanapress.com, Fax: (973)256-8341) pp. 3729-3744 - issn: 0893-7648 - wos: WOS:000402100100053 (5) - scopus: 2-s2.0-84969960041 (5)

11573/954120 - 2017 - Exosome-induced differentiation of neural stem progenitor cells

Poiana, Giancarlo; Stronati, Eleonora; Conti, Roberta; Boussadia, Zaira; Sargiacomo, Massimo; Cacci, Emanuele; Biagioni, Stefano - 04d Abstract in atti di convegno

congresso: 47th Annual Meeting American Society for Neuroscience 2017 (Washington D.C., U.S.A.)

libro: Abstracts of the 2017 Annual Meeting of the American Society for Neuroscience - ()

11573/1183630 - 2017 - Glial phenotype induction of neural stem progenitor cells using astrocyte-derived exosomes

Stronati, E.; Conti, R.; Poiana, G.; Cacci, E.; Biagioni, S. - 04d Abstract in atti di convegno

congresso: Extracellular Vesicles 2017 Meeting - Royal Society of Chemistry (Cambridge, United Kingdom)

libro: Abstracts Extracellular Vesicles 2017 Meeting - ()

11573/954109 - 2016 - Involvement of FUS in cell cycle regulation and ALS pathogenesis

Stronati, Eleonora; Toselli, Camilla; Cacci, Emanuele; Lupo, Giuseppe; Poiana, Giancarlo; Biagioni, Stefano - 04d Abstract in atti di convegno

congresso: XIV Congresso FISV - Federazione Italiana Scienze della Vita (Sapienza Università di Roma, Italia)

libro: Abstracts XIV Congresso FISV - Federazione Italiana Scienze della Vita - ()

11573/779766 - 2015 - RE1 silencing transcription factor/neuron-restrictive silencing factor regulates expansion of adult mouse subventricular zone-derived neural stem/progenitor cells in vitro

Soldati, C; Caramanica, P; Burney, Mj; Toselli, C; Bithell, A; Augusti Tocco, G; Stanton, Lw; Biagioni, Stefano; Buckley, Nj; Cacci, Emanuele - 01a Articolo in rivista

rivista: JOURNAL OF NEUROSCIENCE RESEARCH (New York, NY : John Wiley & Sons) pp. 1203-1214 - issn: 1097-4547 - wos: WOS:000356675600004 (14) - scopus: 2-s2.0-84931572177 (14)

11573/607607 - 2014 - miR-23a and miR-125b regulate neural stem/progenitor cell proliferation by targeting Musashi1.

Gioia, Ubaldo; Valerio Di, Carlo; Pasquale, Caramanica; Camilla, Toselli; Antonella, Cinquino; Marcella, Marchioni; Pietro, Laneve; Biagioni, Stefano; Bozzoni, Irene; Cacci, Emanuele; Elisa, Caffarelli - 01a Articolo in rivista

rivista: RNA BIOLOGY (Georgetown, TX : Landes Bioscience) pp. 1105-1112 - issn: 1547-6286 - wos: WOS:000348463500003 (30) - scopus: 2-s2.0-84921906552 (31)

11573/781377 - 2013 - Effects of FUS/TLS and its mutations on the in vitro properties of Neural Progenitor cell lines and their neural progeny

Camilla, Toselli; Mariangela, Morlando; Bozzoni, Irene; Biagioni, Stefano; Cacci, Emanuele - 04d Abstract in atti di convegno

congresso: 15 convegno nazionale Società Italiana di Neuroscienze (Roma)

11573/516608 - 2013 - Prolonged lifespan with enhanced exploratory behavior in mice overexpressing the oxidized nucleoside triphosphatase hMTH1

Gabriele De, Luca; Ilenia, Ventura; Valentina, Sanghez; Maria Teresa, Russo; Maria Antonietta Ajmone, Cat; Cacci, Emanuele; Alberto, Martire; Patrizia, Popoli; Germana, Falcone; Flavia, Michelini; Marco, Crescenzi; Paolo, Degan; Luisa, Minghetti; Margherita, Bignami; Gemma, Calamandrei - 01a Articolo in rivista

rivista: AGING CELL (-MALDEN:WILEY-BLACKWELL PUBLISHING, INC. -Oxford : Blackwell, 2002-) pp. 695-705 - issn: 1474-9718 - wos: WOS:000321775800018 (32) - scopus: 2-s2.0-84880849702 (33)

11573/505541 - 2013 - The Matrix Metalloproteinase Inhibitor Marimastat Promotes Neural Progenitor Cell Differentiation into Neurons by Gelatinase-Independent TIMP-2-Dependent Mechanisms

Maddalena, Sinno; Biagioni, Stefano; Maria Antonietta Ajmone, Cat; Pafumi, Irene; Pasquale, Caramanica; Virginia, Medda; Gaetana, Tonti; Luisa, Minghetti; Ferdinando, Mannello; Cacci, Emanuele - 01a Articolo in rivista

rivista: STEM CELLS AND DEVELOPMENT (MARY ANN LIEBERT INC, 2 MADISON AVENUE, LARCHMONT, USA, NY, 10538) pp. 345-358 - issn: 1547-3287 - wos: WOS:000313677000001 (24) - scopus: 2-s2.0-84872718436 (24)

11573/386796 - 2012 - Docosahexaenoic acid modulates inflammatory and antineurogenic functions of activated microglial cells

M. A., Ajmone Cat; M. L., Salvatori; Roberta De, Simone; Melissa, Mancini; Biagioni, Stefano; Antonietta, Bernardo; Cacci, Emanuele; Luisa, Minghetti - 01a Articolo in rivista

rivista: JOURNAL OF NEUROSCIENCE RESEARCH (John Wiley & Sons Incorporated:Customer Service, 111 River Street:Hoboken, NJ 07030:(800)225-5945, (201)748-6000, EMAIL: societyinfo@wiley.com, INTERNET: http://www.wiley.com, Fax: (212)748-6551) pp. 575-587 - issn: 0360-4012 - wos: WOS:000299072600006 (80) - scopus: 2-s2.0-84855889053 (81)

11573/501924 - 2012 - Restriction of Neural Precursor Ability to Respond to Nurr1 by Early Regional Specification

Soldati, Chiara; Cacci, Emanuele; Biagioni, Stefano; Carucci, Nicoletta; Lupo, Giuseppe; Carla Perrone, Capano; Saggio, Isabella; Gabriella Augusti, Tocco - 01a Articolo in rivista

rivista: PLOS ONE (San Francisco, CA : Public Library of Science) pp. e51798-.. - issn: 1932-6203 - wos: WOS:000312290800101 (12) - scopus: 2-s2.0-84871177951 (12)

11573/765728 - 2011 - Maintenance of positional identities in region-specific neural stem cell lines following exposure to exogenous morphogens in vitro.

N., Carucci; Cacci, Emanuele; G., Augusti Tocco; Biagioni, Stefano; G., Lupo - 04d Abstract in atti di convegno

congresso: Molecular Mechanisms in Neurosciences (Rome)

11573/762861 - 2011 - Regulation of adult mouse SVZ-derived neural stem cells properties by the transcriptional factor REST

P., Caramanica; C., Toselli; C., Soldati; N., Buckley; Biagioni, Stefano; Cacci, Emanuele - 04d Abstract in atti di convegno

congresso: Stem Cell Symposium (Cambridge, UK)

11573/1064515 - 2010 - Brain inflammation and the neuronal fate: from neurogenesis to neurodegeneration

Antonietta Ajmone-Cat, Maria; Cacci, Emanuele; Minghetti, Luisa - 02a Capitolo o Articolo

libro: Neurovascular Medicine: Pursuing Cellular Longevity for Healthy Aging - (978-019532669-7)

11573/366244 - 2010 - Pro-gliogenic effect of IL-1α in the differentiation of embryonic neural precursor cells in vitro

Maria Antonietta Ajmone, Cat; Cacci, Emanuele; Ylenia, Ragazzoni; Luisa, Minghetti; Biagioni, Stefano - 01a Articolo in rivista

rivista: JOURNAL OF NEUROCHEMISTRY (Editore attuale:BLACKWELL PUBLISHING LTD, 9600 GARSINGTON RD, OXFORD, ENGLAND, OXON, OX4 2DG Lippincott, Williams & Wilkins:530 Walnut Street:Philadelphia, PA 19106:(800)638-3030, (301)223-2300, EMAIL: orders@lww.com, INTERNET: http://www.lww.com, Fax: (301)223-2320, (301)223-2320) pp. 1060-1072 - issn: 0022-3042 - wos: WOS:000276656100023 (25) - scopus: 2-s2.0-77950943601 (29)

11573/27943 - 2009 - Colture di cellule staminali neurali come modello per lo studio di patologie del sistema nervoso, studi farmacologici e di neurotossicità

Cacci, Emanuele; Biagioni, Stefano - 01a Articolo in rivista

rivista: BIOCHIMICA CLINICA (-Milano: Biomedia -Milano: CLAS international) pp. 129-136 - issn: 0393-0564 - wos: (0) - scopus: (0)

11573/228696 - 2009 - Impairment of bidirectional synaptic plasticity in the striatum of a mouse model of DYT1 dystonia: role of endogenous acetylcholine

G., Martella; A., Tassone; G., Sciamanna; P., Platania; D., Cuomo; M. T., Viscomi; P., Bonsi; Cacci, Emanuele; Biagioni, Stefano; A., Usiello; G., Bernardi; N., Sharma; D. G., Standaert; A., Pisani - 01a Articolo in rivista

rivista: BRAIN (-Oxford: Oxford University Press -Oxford: Clarendon Press -London: Macmillan -London: Butterworths Scientific Publications, 1878-) pp. 2336-2349 - issn: 0006-8950 - wos: WOS:000269963600006 (171) - scopus: 2-s2.0-71549148437 (190)

11573/227350 - 2009 - Neural stem cells at the crossroads: MMPs may tell the way

Gaetana A., Tonti; Ferdinando, Mannello; Cacci, Emanuele; Biagioni, Stefano - 01a Articolo in rivista

rivista: THE INTERNATIONAL JOURNAL OF DEVELOPMENTAL BIOLOGY (Universidad del Pais Vasco:Servicio Editorial, Apartado 1397, E-48080 Bilbao Spain:011 34 94 6015126, EMAIL: luxedito@lg.ehu.es, INTERNET: http://www.ehu.es/servicios/se_az/, Fax: 011 34 94 4801314) pp. 1-17 - issn: 0214-6282 - wos: WOS:000264089000001 (35) - scopus: 2-s2.0-67449168576 (36)

11573/364223 - 2008 - In vitro neuronal and glial differentiation from embryonic or adult neural precursor cells are differently affected by chronic or acute activation of microglia

Cacci, Emanuele; Maria Antonietta Ajmone, Cat; Anelli, Tonino; Biagioni, Stefano; Luisa, Minghetti - 01a Articolo in rivista

rivista: GLIA (John Wiley & Sons Incorporated:Customer Service, 111 River Street:Hoboken, NJ 07030:(800)225-5945, (201)748-6000, EMAIL: societyinfo@wiley.com, INTERNET: http://www.wiley.com, Fax: (212)748-6551) pp. 412-425 - issn: 0894-1491 - wos: WOS:000253277100005 (183) - scopus: 2-s2.0-38949139570 (197)

11573/133210 - 2008 - Non steroidal anti-inflammatory drugs and neurogenesis in the adult mammalian brain

Maria Ajmone, Cat; Cacci, Emanuele; Luisa, Minghetti - 01a Articolo in rivista

rivista: CURRENT PHARMACEUTICAL DESIGN (Bentham Science Publishers BV:PO Box 7917, Exec Ste Y 26, Saif Zone Sharjah Uae:011 971 6 5571132, EMAIL: benthams@emirates.net.ae, INTERNET: http://www.bentham.org, Fax: 011 971 6 5571134) pp. 1435-1442 - issn: 1381-6128 - wos: WOS:000256618300010 (19) - scopus: 2-s2.0-47249089635 (20)

11573/133115 - 2007 - Generation of human cortical neurons from a new immortal fetal neural stem cell line

Cacci, Emanuele; A., Villa; M., Parmar; M., Cavallaro; N., Mandahl; O., Lindvall; A., Martinez Serrano; Z., Kokaia - 01a Articolo in rivista

rivista: EXPERIMENTAL CELL RESEARCH (Academic Press Incorporated:6277 Sea Harbor Drive:Orlando, FL 32887:(800)543-9534, (407)345-4100, EMAIL: ap@acad.com, INTERNET: http://www.idealibrary.com, Fax: (407)352-3445) pp. 588-601 - issn: 0014-4827 - wos: WOS:000244283200014 (38) - scopus: 2-s2.0-33846850177 (42)

11573/133207 - 2006 - Persistent production of neurons from adult brain stem cells during recovery after stroke

Pär, Thored; Andreas, Arvidsson; Cacci, Emanuele; H., Alhenius; Therese, Kallur; K., Ekdal; Zaal, Kokaia; Olle, Lindvall - 01a Articolo in rivista

rivista: STEM CELLS (Alphamed Press Incorporated:1 Prestige Place, Suite 290:Miamisburg, OH 45342:(937)291-2355, EMAIL: alphamedpress@alphamedpress.com, INTERNET: http://www.alphamedpress.com, Fax: (937)291-4229) pp. 739-747 - issn: 1066-5099 - wos: WOS:000240636200030 (573) - scopus: 2-s2.0-33745001464 (636)

11573/133206 - 2005 - Microglia-derived tumor necrosis factor ? exaggerates death of newborn hippocampal progenitor cells in vitro

Cacci, Emanuele; J. H., Claasen; K., Kokaia - 01a Articolo in rivista

rivista: JOURNAL OF NEUROSCIENCE RESEARCH (John Wiley & Sons Incorporated:Customer Service, 111 River Street:Hoboken, NJ 07030:(800)225-5945, (201)748-6000, EMAIL: societyinfo@wiley.com, INTERNET: http://www.wiley.com, Fax: (212)748-6551) pp. 789-797 - issn: 0360-4012 - wos: WOS:000229484900006 (155) - scopus: 2-s2.0-21844448903 (166)

11573/232945 - 2005 - Aflatoxin B1 and cell cycle perturbation.

R., Ricordy; Cacci, Emanuele; Tocco, Gabriella - 02a Capitolo o Articolo

libro: Reviews in Food and Nutrition Toxicity - (9780849335198)

11573/233028 - 2004 - Espressione genica differenziale e differenziamento cellulare.

Cacci, Emanuele; Tocco, Gabriella - 02a Capitolo o Articolo

libro: Il differenziamento dei tessuti e degli organi - (9788820736385)

11573/250454 - 2003 - Hepatocyte growth factor stimulates cell motility in cultures of the striatal progenitor cells ST14A

Cacci, Emanuele; M., Salani; S., Anastasi; I., Perroteau; Poiana, Giancarlo; Biagioni, Stefano; Tocco, Gabriella - 01a Articolo in rivista

rivista: JOURNAL OF NEUROSCIENCE RESEARCH (John Wiley & Sons Incorporated:Customer Service, 111 River Street:Hoboken, NJ 07030:(800)225-5945, (201)748-6000, EMAIL: societyinfo@wiley.com, INTERNET: http://www.wiley.com, Fax: (212)748-6551) pp. 760-768 - issn: 0360-4012 - wos: WOS:000186849700013 (21) - scopus: 2-s2.0-0345293317 (19)

11573/254869 - 2002 - Impairment of cell cycle progression by aflatoxin B1 in human cell lines

R., Ricordy; G., Gensabella; Cacci, Emanuele; Tocco, Gabriella - 01a Articolo in rivista

rivista: MUTAGENESIS (Oxford University Press:Journals Department, Great Clarendon Street, Oxford OX2 6DP United Kingdom:011 44 1865 556767, EMAIL: jnlorders@oup.co.uk, INTERNET: http://www.oup.co.uk, Fax: 011 44 1865 267485) pp. 241-249 - issn: 0267-8357 - wos: WOS:000175247700010 (44) - scopus: 2-s2.0-0036001264 (47)

11573/248849 - 2001 - Uso di colture di neuroblastoma in studi di neurotossicità

Cacci, Emanuele; Bonsi, P; Tocco, Gabriella; Biagioni, Stefano - 01a Articolo in rivista

rivista: BIOCHIMICA CLINICA (-Milano: Biomedia -Milano: CLAS international) pp. 319-326 - issn: 0393-0564 - wos: (0) - scopus: (0)