EMAN MOHAMED A FAKRON

Dottoressa di ricerca

ciclo: XXXIV



Titolo della tesi: The role of Nasal Cytology in Identifying Rhinitis phenotypes for managing Allergen Immunotherapy in Clinical Practice

Abstract Backgrounds Allergic rhinitis (AR) and non-allergic rhinitis with eosinophils (NARES) share type 2 inflammation characterized by nasal eosinophilic infiltrate. Allergen immunotherapy (AIT) is the unique specific treatment for AR, but some patients do not respond. AIT failure may depend on possible comorbidity, mainly concerning NARES. Methods 33 patients (15 males and 18 females, mean age 44 years) with AR due to house dust mites allergy were enrolled and treated with sublingual AIT using a monomeric allergoid (LAIS). AIT lasted three years. Symptom perception was assessed by visual analog scale (VAS). Symptoms included nasal obstruction, rhinorrhea, sneezing, cough, and olfaction. Nasal cytology evaluated the presence of eosinophils. Patients were evaluated at baseline, after six months, and after one, two, and three years. Objective The current study, therefore, aimed at investigating the role of nasal cytology in identifying non-responders to AIT. Results 28 patients significantly (p<0.001) improved already after six months and showed a progressive reduction of eosinophilic infiltrate (p<0.001). The five non-responder patients continued to complain of symptoms, and consistently nasal inflammation did not disappear. Conclusion Nasal cytology is a fruitful tool to identify non-responder to AIT and phenotype mixed rhinitis, such as AR associated with NARES. Therefore, nasal cytology is fruitful in AIT management, mainly in non-responders. Keywords: allergic rhinitis; NARES; mixed rhinitis; allergen immunotherapy; nasal cytology; phenotype; responder

Produzione scientifica

11573/1421459 - 2020 - Effects of paraprobiotic MIMLh5 in the treatment of chronic rhinopharyngitis
Cavaliere, Carlo; Cantone, Elena; Luperto, Paolo; Orlando, Maria P.; Gnesutta, Michele; Begvarfaj, Elona; De Vincentiis, Marco; Fakron, Eman; Masieri, Simonetta - 01a Articolo in rivista
rivista: OTORINOLARINGOLOGIA (Torino; Milano: Minerva Medica) pp. 38-42 - issn: 0392-6621 - wos: (0) - scopus: 2-s2.0-85089386387 (2)

11573/1433978 - 2020 - Role of invariant natural killer t cells in patients with tonsillar hypertrophy: the tonsil as an immunological organ
Derakhshani, A.; Mofateh, M. R.; Masieri, S.; Ghadri, H.; Cavaliere, C.; Fakron, E.; Fereidouni, M. - 01f Lettera, Nota
rivista: JOURNAL OF BIOLOGICAL REGULATORS & HOMEOSTATIC AGENTS (Wichtig Editore:Via Friuli 72 74, I 20135 Milan Italy:011 39 02 5455122, 011 39 2 55195443, EMAIL: info@wichtig-publisher.com, INTERNET: http://www.wichtig-publisher.com, Fax: 011 39 2 55195971) pp. 1039-1044 - issn: 0393-974X - wos: WOS:000550697300034 (0) - scopus: 2-s2.0-85088051895 (0)

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