ELISABETTA FASIELLO

Dottoressa di ricerca

ciclo: XXXV


supervisore: Prof. Luigi De Gennaro

Titolo della tesi: Insomnia Disorder: association between EEG spectral features, Sleep State Misperception, and Time Estimation Abilities

One of the most striking features of Insomnia Disorder (ID) patients is their tendency to underestimate the length of sleep periods in favor of overestimating periods of wakefulness during sleep. This phenomenon is referred to as the Sleep State Misperception (SSM). Although its impact is currently neglected in diagnostic manuals, its existence and magnitude has always been well renowned in both clinical and research settings. Although considered an elusive phenomenon, during recent years sleep researchers have advanced several electrophysiological and behavioral hypotheses to explain its occurrence. Specifically, several electroencephalographic (EEG) alterations point towards physiological expression of an enhanced level of awareness during sleep and an impaired cortical synchronization in ID patients that may result in SSM. In spite of this neurophysiological evidence, local EEG underpinnings of the phenomenon in ID are far from being understood, and several researchers are now also oriented in integrating these findings with those concerning cognitive and behavioral activity. Indeed, a cognitive explanation for the SSM in ID considered a possible impairment in the Time Estimation Abilities (TEAs) during sleep and wakefulness. Up to now, studies aimed at investigating topographical EEG dynamics and sleep microstructural changes, as well as cognitive and behavioral impairments that may explain the SSM phenomenon in ID, are still few and present several methodological limitations. In this view, a clear framework of the electrophysiological and behavioral mechanisms underlying SSM is still missing. The present study, through two experiments, aims to explore all aspects (i.e., electrophysiological, cognitive and behavioral) that likely characterized SSM in ID, providing for the first time a unique framework to explain this fascinating phenomenon that appears relevant from both theoretical and clinical standpoints. In the first experiment, starting from the hypothesis that TEAs in wake can be influenced by subjective sleep features and sleep quality, 61 healthy controls (HCs) participants were monitored for one week to collect subjective sleep indices and were tested for the TEAs through a Time Reproduction Task (TRT) ad hoc created. In the second experiment, 16 ID patients and 15 sex- and age-matched HCs underwent a whole night polysomnographic (PSG) recording, followed by the administration of a sleep diary to collect subjective sleep estimates and by the TRT. Correlational analysis showed that in all subjects, the delta/beta ratio was positively correlated with the underestimation of the Total Sleep Time (TST). Moreover, results from the two experiments suggest that the TEAs, both during wake and sleep, seem to depend on the hyperarousal state that pervades the ID during the 24 hours.

Produzione scientifica

11573/1700314 - 2024 - Neurophysiological Parameters Influencing Sleep–Wake Discrepancy in Insomnia Disorder: A Preliminary Analysis on Alpha Rhythm during Sleep Onset
Berra, Francesca; Fasiello, Elisabetta; Zucconi, Marco; Casoni, Francesca; De Gennaro, Luigi; Ferini-Strambi, Luigi; Galbiati, Andrea - 01a Articolo in rivista
rivista: BRAIN SCIENCES (Basel : Molecular Diversity Preservation International) pp. - - issn: 2076-3425 - wos: (0) - scopus: (0)

11573/1697775 - 2023 - Disturbo di insonnia e Sleep State Misperception (SSM): correlati elettrofisiologici e comportamentali
Fasiello, E.; Gorgoni, M.; Galbiati, A.; Sforza, M.; Berra, F.; Scarpelli, S.; Alfonsi, V.; Annarumma, L.; Casoni, F.; Zucconi, M.; Castronovo, V.; Ferini-Strambi, L.; De Gennaro, L. - 04d Abstract in atti di convegno
congresso: XXI Congresso Nazionale Società Italiana di Terapia Comportamentale e Cognitiva (SITCC) (Bari)
libro: XXI Congresso Nazionale Società Italiana di Terapia Comportamentale e Cognitiva (SITCC), Libro degli Abstract - ()

11573/1694044 - 2023 - Challenging subjective excessive daytime sleepiness as an insomnia symptom: a retrospective study
Fasiello, Elisabetta; Mombelli, Samantha; Sforza, Marco; Zucconi, Marco; Casoni, Francesca; Chadia, Konstantina; Castronovo, Vincenza; Steiropoulos, Paschalis; De Gennaro, Luigi; Ferini‐Strambi, Luigi; Galbiati, Andrea - 01a Articolo in rivista
rivista: JOURNAL OF SLEEP RESEARCH (Blackwell Science Limited:PO Box 88, Oxford OX2 0NE United Kingdom:011 44 1865 776868, 011 44 1865 206038, EMAIL: journals.cs@blacksci.co.uk, INTERNET: http://www.blackwell-science.com, Fax: 011 44 1865 721205) pp. - - issn: 0962-1105 - wos: WOS:001117057900001 (0) - scopus: (0)

11573/1657415 - 2022 - Sleep onset misperception in insomnia disorder: a pilot study with methodological implications
Berra, F.; Galbiati, A.; Fasiello, E.; Sforza, M.; Casoni, F.; Zucconi, M.; Castronovo, V.; De Gennaro, L.; Ferini-Strambi, L. - 01h Abstract in rivista
rivista: JOURNAL OF SLEEP RESEARCH (Blackwell Science Limited:PO Box 88, Oxford OX2 0NE United Kingdom:011 44 1865 776868, 011 44 1865 206038, EMAIL: journals.cs@blacksci.co.uk, INTERNET: http://www.blackwell-science.com, Fax: 011 44 1865 721205) pp. 146-146 - issn: 0962-1105 - wos: (0) - scopus: (0)

11573/1657727 - 2022 - Dreaming in Parasomnias: REM Sleep Behavior Disorder as a Model
Fasiello, Elisabetta; Scarpelli, Serena; Gorgoni, Maurizio; Alfonsi, Valentina; De Gennaro, Luigi - 01g Articolo di rassegna (Review)
rivista: JOURNAL OF CLINICAL MEDICINE (MDPI Publishing, Basel, Switzerland) pp. 6379- - issn: 2077-0383 - wos: WOS:000881085500001 (1) - scopus: 2-s2.0-85141693896 (1)

11573/1657795 - 2022 - A systematic review of dreams and nightmares recall in patients with rapid eye movement sleep behaviour disorder
Fasiello, Elisabetta; Scarpelli, Serena; Gorgoni, Maurizio; Alfonsi, Valentina; Galbiati, Andrea; De Gennaro, Luigi - 01g Articolo di rassegna (Review)
rivista: JOURNAL OF SLEEP RESEARCH (Blackwell Science Limited:PO Box 88, Oxford OX2 0NE United Kingdom:011 44 1865 776868, 011 44 1865 206038, EMAIL: journals.cs@blacksci.co.uk, INTERNET: http://www.blackwell-science.com, Fax: 011 44 1865 721205) pp. - - issn: 0962-1105 - wos: WOS:000876779900001 (0) - scopus: 2-s2.0-85141404416 (0)

11573/1657416 - 2022 - K-complexes density changes in isolated REM sleep behavior disorder and relations with cognitive functioning
Gorgoni, M.; Pietrogiacomi, F.; Reda, F.; Fasiello, E.; Galbiati, A.; Camaioni, M.; Scarpelli, S.; Alfonsi, V.; Casoni, F.; Zucconi, M.; Ferini-Strambi, L.; De Gennaro, L. - 01h Abstract in rivista
rivista: JOURNAL OF SLEEP RESEARCH (Blackwell Science Limited:PO Box 88, Oxford OX2 0NE United Kingdom:011 44 1865 776868, 011 44 1865 206038, EMAIL: journals.cs@blacksci.co.uk, INTERNET: http://www.blackwell-science.com, Fax: 011 44 1865 721205) pp. -151 - issn: 0962-1105 - wos: (0) - scopus: (0)

11573/1651485 - 2022 - Alterations of the human K-complexes during NREM sleep in isolated REM sleep behaviour disorder
Gorgoni, M.; Pietrogiacomi, F.; Reda, F.; Galbiati, A.; Fasiello, E.; Camaioni, M.; Scarpelli, S.; Alfonsi, V.; Casoni, F.; Zucconi, M.; Ferini-Strambi, L.; De Gennaro, L. - 01h Abstract in rivista
rivista: SLEEP MEDICINE (Amsterdam : Elsevier) pp. 223-224 - issn: 1389-9457 - wos: WOS:000832018700584 (0) - scopus: (0)

11573/1624440 - 2022 - The Oneiric Activity during and after the COVID-19 Total Lockdown in Italy: A Longitudinal Study
Gorgoni, Maurizio; Scarpelli, Serena; Alfonsi, Valentina; Annarumma, Ludovica; Pellegrini, Elisa; Fasiello, Elisabetta; Cordone, Susanna; D’Atri, Aurora; Salfi, Federico; Amicucci, Giulia; Ferrara, Michele; Pazzaglia, Mariella; De Gennaro, Luigi - 01a Articolo in rivista
rivista: INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH (Basel: MDPI 2003-) pp. 3857- - issn: 1660-4601 - wos: WOS:000780514600001 (5) - scopus: 2-s2.0-85126902713 (6)

11573/1587569 - 2021 - Functional connectivity changes in insomnia disorder: a systematic review
Fasiello, Elisabetta; Gorgoni, Maurizio; Scarpelli, Serena; Alfonsi, Valentina; Strambi, Luigi Ferini; De Gennaro, Luigi - 01g Articolo di rassegna (Review)
rivista: SLEEP MEDICINE REVIEWS (Harcourt Publishers Limited:Foots Cray High Street, Sidcup Kent DA14 5HP United Kingdom:011 44 20 83085700, EMAIL: journals@harcourt.com, INTERNET: http://www.harcourt-international.com, Fax: 011 44 20 83085876) pp. - - issn: 1087-0792 - wos: WOS:000752481300009 (23) - scopus: 2-s2.0-85121234116 (27)

11573/1581512 - 2021 - Exploring the functional role and neural correlates of K-complexes in isolated rapid eye movement sleep behavior disorder
Galbiati, Andrea; Carli, Giulia; Fasiello, Elisabetta; Casoni, Francesca; Zucconi, Marco; De Gennaro, Luigi; Perani, Daniela; Ferini-Strambi, Luigi - 01a Articolo in rivista
rivista: CORTEX (Primo editore: Tipografica Varese, Varese Attuale:Masson SPA:via Flli Bressan 2, I 20126 Milan Italy:011 39 02 27074286, EMAIL: aboonamenti@masson.it, INTERNET: http://www.masson.it, Fax: 011 39 02 27074210) pp. 105-114 - issn: 0010-9452 - wos: WOS:000721562900001 (3) - scopus: 2-s2.0-85117725467 (3)

11573/1487050 - 2020 - The association between emotional dysregulation and REM sleep features in insomnia disorder
Galbiati, A.; Sforza, M.; Fasiello, E.; Casoni, F.; Marrella, N.; Leitner, C.; Zucconi, M.; Ferini-Strambi, L. - 01a Articolo in rivista
rivista: BRAIN AND COGNITION (New York: Academic Press, [c1982]-) pp. 105642- - issn: 0278-2626 - wos: WOS:000600893900009 (6) - scopus: 2-s2.0-85095954450 (4)

11573/1402327 - 2019 - SLOW WAVE SLEEP AND RESPONSE TO COGNITIVE BEHAVIORAL THERAPY FOR INSOMNIA
Castronovo, V; Sforza, M; Fasiello, E; Farina, R; Galbiati, A; Strambi, Lf - 01a Articolo in rivista
rivista: SLEEP (American Sleep Disorders Association:6301 Bandel Road Northwest Suite 101:Rochester, MN 55901:(507)287-6006, EMAIL: bhyland@asda.org, INTERNET: http://www.asda.org, Fax: (507)287-6008) pp. - - issn: 0161-8105 - wos: WOS:000471071001190 (0) - scopus: (0)

11573/1402332 - 2019 - Neuropsychological, electrophysiological, and neuroimaging biomarkers for REM behavior disorder
Ferini-Strambi, L.; Fasiello, E.; Sforza, M.; Salsone, M.; Galbiati, A. - 01g Articolo di rassegna (Review)
rivista: EXPERT REVIEW OF NEUROTHERAPEUTICS (-London, United Kingdom: Expert Reviews Ltd -London, United Kingdom: Future Drugs Limited) pp. 1069-1087 - issn: 1473-7175 - wos: WOS:000475025100001 (17) - scopus: 2-s2.0-85073184780 (16)

11573/1402324 - 2019 - Rem Sleep Without Atonia (RSWA) and neuropsychological function in REM sleep Behavior Disorder
Ferini-Strambi, Luigi; Galbiati, Andrea; Fasiello, Elisabetta; Montanaro, Massimo; Zucconi, Marco - 01h Abstract in rivista
rivista: SLEEP (American Sleep Disorders Association:6301 Bandel Road Northwest Suite 101:Rochester, MN 55901:(507)287-6006, EMAIL: bhyland@asda.org, INTERNET: http://www.asda.org, Fax: (507)287-6008) pp. A259-A260 - issn: 0161-8105 - wos: WOS:000471071002219 (0) - scopus: (0)

11573/1402341 - 2019 - Impact of phenotypic heterogeneity of insomnia on the patients’ response to cognitive-behavioral therapy for insomnia: Current perspectives
Galbiati, A.; Sforza, M.; Fasiello, E.; Castronovo, V.; Ferini-Strambi, L. - 01g Articolo di rassegna (Review)
rivista: NATURE AND SCIENCE OF SLEEP ([Auckland, N.Z.] : Dove Medical Press, c2009-) pp. 367-376 - issn: 1179-1608 - wos: WOS:000503969600001 (7) - scopus: 2-s2.0-85075911420 (9)

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