ELENA PASTORELLI

Dottoressa di ricerca

ciclo: XXXIII



Titolo della tesi: Deep sleep and its cognitive effects - Slow wave activity and the learning and sleep cycle

Sleep is definitely an essential cerebral state for all living beings. The occurrence of sleep passed through the evolutionary sieve and is widespread in animal species. Sleep is known to be beneficial to cognitive and mnemonic tasks, while chronic sleep deprivation is detrimental. Indeed, young humans pass most of their time sleeping, and younger are the subjects that have to learn at faster rates. In adults, sleep deprivation is detrimental for cognition and it is one of the worst tortures that can be inflicted. Despite the importance of the phenomenon in relation with the cognitive effects, a complete understanding of its functions and underlying mechanisms is still lacking. Recent studies focused the attention on a specific phase of sleep in relation to cognition and learning: the deepest of physiological non-REM sleep stage in which specific phenomena like Slow Oscillations (SO) are the default emergent activity of the cortical network and are observed as an alternation between Down states (characterized by nearly silent neurons) and Up states (with intense neuronal activity). Among the contribution of this work, there is the building of fundamental instruments for the study of this phenomenon and of its interplay with learning, also thanks to the experimental context in which I am involved: the European Human Brain Project (HBP) and The Motor Control and Cognition Lab (MCC_lab) directed by Prof. Stefano Ferraina at Sapienza University. Basically, we developed an analysis tool for the extraction of salient feature (velocity, direction, planarity of the slow waves and other specific features) from the experimental recordings in vivo acquired with different methodologies (electrophysiology, calcium imaging, etc.), and simulations tools able to reproduce the behaviour of large portion of the cerebral cortex. To complement this activity, we built theoretical models and simulation tools able to reproduce the SWA and their effect on learning, demonstrating that such a cerebral state has a fundamental role in memory consolidation. The simulated outputs of these theoretical models are then analyzed with the same instruments used to analyze in vivo recorded data, allowing a faster and simpler comparison between experimental and synthetic data. In the end, I also had the chance to analyze signals recorded in vivo on monkeys during learning tasks, more specifically during the countermanding and the transitive inference tasks. I had not the possibility to verify the effect of sleep on these tasks, due to the impossibility of setting-up new experiments on animals in the last period, but the activity done, other then reporting interesting results, was preparatory to the study of the role of sleep on learning process and memory consolidation. Moreover, it gave me the possibility to work on data directly acquired in an experimental lab, that I consider a complementary activity essential for my scientific background.

Produzione scientifica

11573/1672591 - 2021 - Simulations approaching data: cortical slow waves in inferred models of the whole hemisphere of mouse
Capone, Cristiano; De Luca, Chiara; De Bonis, Giulia; Gutzen, Robin; Bernava, Irene; Pastorelli, Elena; Simula, Francesco; Lupo, Cosimo; Tonielli, Leonardo; Letizia Allegra Mascaro, Anna; Resta, Francesco; Pavone, Enea Francesco; Denker, Micheal; Stanislao Paolucci, Pier - 01a Articolo in rivista
rivista: COMMUNICATIONS BIOLOGY ([London]: Springer Nature) pp. - - issn: 2399-3642 - wos: WOS:000948919700001 (0) - scopus: (0)

11573/1491776 - 2021 - Thalamo-cortical spiking model of incremental learning combining perception, context and NREM-sleep-mediated noise-resilience
Golosio, Bruno; De Luca, Chiara; Capone, Cristiano; Pastorelli, Elena; Stegel, Giovanni; Tiddia, Gianmarco; De Bonis, Giulia; Stanislao Paolucci, Pier - 01a Articolo in rivista
rivista: PLOS COMPUTATIONAL BIOLOGY (San Francisco, CA : Public Library of Science, [2005]-) pp. - - issn: 1553-734X - wos: WOS:000670617900003 (9) - scopus: 2-s2.0-85108910093 (10)

11573/1491772 - 2021 - Fast simulations of highly-connected spiking cortical models using GPUs
Golosio, Bruno; Tiddia, Gianmarco; De Luca, Chiara; Pastorelli, Elena; Simula, Francesco; Stanislao Paolucci, Pier - 01a Articolo in rivista
rivista: FRONTIERS IN COMPUTATIONAL NEUROSCIENCE (Lausanne : Frontiers Research Foundation, 2007-) pp. - - issn: 1662-5188 - wos: WOS:000624309600001 (22) - scopus: 2-s2.0-85101984027 (22)

11573/1491656 - 2020 - Learning and sleep in a thalamo-cortical multi-area model
De Luca, Chiara; Capone, Cristiano; Pastorelli, Elena; De Bonis, Giulia; Stanislao Paolucci, Pier - 04f Poster
congresso: HBP Summit 2020 (Athens)
libro: "Summit 2020 posters" HBP Summit 2020 (https://summit2020.humanbrainproject.eu/posters.pdf) - ()

11573/1491707 - 2020 - Thalamo-cortical spiking model of incremental learning combining perception, context and NREM-sleep-mediated noise-resilience
De Luca, Chiara; Golosio, Bruno; Capone, Cristiano; Pastorelli, Elena; Stegel, Giovanni; Tiddia, Gianmarco; De Bonis, Giulia; Stanislao Paolucci, Pier - 04d Abstract in atti di convegno
congresso: NEST Conference 2020 (Online)
libro: Abstract of oral presentation at NEST Conference 2020, 29-30 June 2020, p. 9, - ()

11573/1292264 - 2019 - Sleep-like slow oscillations improve visual classification through synaptic homeostasis and memory association in a thalamo-cortical model
Capone, Cristiano; Pastorelli, Elena; Golosio, Bruno; Paolucci, Pier Stanislao - 01a Articolo in rivista
rivista: SCIENTIFIC REPORTS (London: Springer Nature London: Nature Publishing Group) pp. 8990- - issn: 2045-2322 - wos: WOS:000472138400002 (20) - scopus: 2-s2.0-85067618838 (23)

11573/1353310 - 2019 - NaNet: a Reconfigurable PCIe Network Interface Card Architecture for Real-time Distributed Heterogeneous Stream Processing in the NA62 Low Level Trigger
Cretaro, Paolo; Biagioni, Andrea; Frezza, Ottorino; Lo Cicero, Francesca; Lonardo, Alessandro; Martinelli, Michele; Paolucci, Pier Stanislao; Pontisso, Luca; Simula, Francesco; Vicini, Piero; Capone, Cristiano; Capuani, Fabrizio; De Bonis, Giulia; Pastorelli, Elena; Ammendola, Roberto; Lamanna, Gianluca; Sozzi, Marco; Piandani, Roberto; Soldi, Dario - 04b Atto di convegno in volume
congresso: Topical Workshop on Electronics for Particle Physics (TWEPP18) (Antwerpen; Belgium)
libro: Proceedings, Topical Workshop on Electronics for Particle Physics (TWEPP18) - ()

11573/1348738 - 2019 - Scaling of a large-scale simulation of synchronous slow-wave and asynchronous awake-like activity of a cortical model with long-range interconnections
Pastorelli, E.; Capone, C.; Simula, F.; Sanchez-Vives, M. V.; Del Giudice, P.; Mattia, M.; Paolucci, P. S. - 01a Articolo in rivista
rivista: FRONTIERS IN SYSTEMS NEUROSCIENCE (Lausanne : Frontiers Research Foundation, 2007-) pp. - - issn: 1662-5137 - wos: WOS:000477744100001 (4) - scopus: 2-s2.0-85072112015 (6)

11573/1292554 - 2019 - Real-Time Cortical Simulations. Energy and Interconnect Scaling on Distributed Systems
Simula, F.; Pastorelli, E.; Paolucci, P. S.; Martinelli, M.; Lonardo, A.; Biagioni, A.; Capone, C.; Capuani, F.; Cretaro, P.; De Bonis, G.; Lo Cicero, F.; Pontisso, L.; Vicini, P.; Ammendola, R. - 04b Atto di convegno in volume
congresso: 27th Euromicro International Conference on Parallel, Distributed and Network-Based Processing, PDP 2019 (Pavia; Italia)
libro: Proceedings - 27th Euromicro International Conference on Parallel, Distributed and Network-Based Processing, PDP 2019 - (978-1-7281-1644-0)

11573/1353317 - 2018 - Real-time heterogeneous stream processing with NaNet in the NA62 experiment
Ammendola, R.; Barbanera, M.; Biagioni, A.; Cretaro, P.; Frezza, O.; Lamanna, G.; Lo Cicero, F.; Lonardo, A.; Martinelli, M.; Pastorelli, E.; Paolucci, P. S.; Piandani, R.; Pontisso, L.; Rossetti, D.; Simula, F.; Sozzi, M.; Valente, P.; Vicini, P. - 04b Atto di convegno in volume
congresso: 18th International Workshop on Advanced Computing and Analysis Techniques in Physics Research, ACAT 2017 (Washington, DC; USA)
libro: Journal of Physics: Conference Series - ()

11573/1340355 - 2018 - Large Scale Low Power Computing System: Status of Network Design in ExaNeSt and EuroExa Projects
Ammendola, R.; Biagioni, A.; Capuani, F.; Cretaro, P.; De Bonis, G.; Lo Cicero, F.; Lonardo, A.; Martinelli, M.; Paolucci, P. S.; Pastorelli, E.; Pontisso, L.; Simula, F.; Vicini, P. - 02a Capitolo o Articolo
libro: Advances in Parallel Computing - (978-1-61499-842-6; 978-1-61499-843-3)

11573/1340361 - 2018 - The Brain on Low Power Architectures: Efficient Simulation of Cortical Slow Waves and Asynchronous States
Ammendola, R.; Biagioni, A.; Capuani, F.; Cretaro, P.; De Bonis, G.; Lo Cicero, F.; Lonardo, A.; Martinelli, M.; Paolucci, P. S.; Pastorelli, E.; Pontisso, L.; Simula, F.; Vicini, P. - 02a Capitolo o Articolo
libro: Advances in Parallel Computing - (978-1-61499-842-6; 978-1-61499-843-3)

11573/1353330 - 2018 - The INFN COSA Project: Low-Power Computing and Storage
Cesini, D.; Corni, E.; Falabella, A.; Ferraro, A.; Lama, L.; Morganti, L.; Calore, E.; Schifano, S. F.; Michelotto, M.; Alfieri, R.; De Pietri, R.; Boccali, T.; Biagioni, A.; Lo Cicero, F.; Lonardo, A.; Martinelli, M.; Paolucci, P. S.; Pastorelli, E.; Vicini, P. - 04b Atto di convegno in volume
congresso: ParCo 2017 - MiniSymposium on Energy Aware Scientific Computing on Low Power and Heterogeneous Architectures (Bologna (ITALY))
libro: Advances in Parallel Computing - ()

11573/1340339 - 2018 - Next generation of Exascale-class systems: ExaNeSt project and the status of its interconnect and storage development
Katevenis, M.; Ammendola, R.; Biagioni, A.; Cretaro, P.; Frezza, O.; Lo Cicero, F.; Lonardo, A.; Martinelli, M.; Paolucci, P. S.; Pastorelli, E.; Simula, F.; Vicini, P.; Taffoni, G.; Pascual, J. A.; Navaridas, J.; Lujan, M.; Goodacre, J.; Lietzow, B.; Mouzakitis, A.; Chrysos, N.; Marazakis, M.; Gorlani, P.; Cozzini, S.; Brandino, G. P.; Koutsourakis, P.; Ruth, J. V.; Zhang, Y.; Kersten, M. - 01a Articolo in rivista
rivista: MICROPROCESSORS AND MICROSYSTEMS (Butterworth Heinemann Publishers:Linacre House Jordan Hill, Oxford OX2 8DP United Kingdom:011 44 1865 314569, EMAIL: bhmarketing@repp.co.uk, INTERNET: http://www.laxtonsprices.co.uk, Fax: 011 44 1865 314569) pp. 58-71 - issn: 0141-9331 - wos: WOS:000441486700006 (17) - scopus: 2-s2.0-85048510982 (18)

11573/1183970 - 2018 - Gaussian and Exponential Lateral Connectivity on Distributed Spiking Neural Network Simulation
Pastorelli, Elena; Paolucci, Pier Stanislao; Simula, Francesco; Biagioni, Andrea; Capuani, Fabrizio; Cretaro, Paolo; De Bonis, Giulia; Lo Cicero, Francesca; Lonardo, Alessandro; Martinelli, Michele; Pontisso, Luca; Vicini, Piero; Ammendola, Roberto - 04b Atto di convegno in volume
congresso: PDP2018 (Cambridge)
libro: 2018 26th Euromicro International Conference on Parallel, Distributed and Network-based Processing (PDP) - (9781538649756)

11573/1353444 - 2017 - Graphical processors for HEP trigger systems
Ammendola, R.; Biagioni, A.; Chiozzi, S.; Cotta Ramusino, A.; Di Lorenzo, S.; Fantechi, R.; Fiorini, M.; Frezza, O.; Lamanna, G.; Lo Cicero, F.; Lonardo, A.; Martinelli, M.; Neri, I.; Paolucci, P. S.; Pastorelli, E.; Piandani, R.; Pontisso, L.; Rossetti, D.; Simula, F.; Sozzi, M.; Vicini, P. - 01a Articolo in rivista
rivista: NUCLEAR INSTRUMENTS & METHODS IN PHYSICS RESEARCH. SECTION A, ACCELERATORS, SPECTROMETERS, DETECTORS AND ASSOCIATED EQUIPMENT (Elsevier BV:PO Box 211, 1000 AE Amsterdam Netherlands:011 31 20 4853757, 011 31 20 4853642, 011 31 20 4853641, EMAIL: nlinfo-f@elsevier.nl, INTERNET: http://www.elsevier.nl, Fax: 011 31 20 4853598) pp. 612-615 - issn: 0168-9002 - wos: WOS:000394556300145 (0) - scopus: 2-s2.0-84977564952 (0)

11573/1353332 - 2017 - Real-time track-less Cherenkov ring fitting trigger system based on Graphics Processing Units
Ammendola, R.; Biagioni, A.; Chiozzi, S.; Cretaro, P.; Cotta Ramusino, A.; Di Lorenzo, S.; Fantechi, R.; Fiorini, M.; Frezza, O.; Gianoli, A.; Lamanna, G.; Lo Cicero, F.; Lonardo, A.; Martinelli, M.; Neri, I.; Paolucci, P. S.; Pastorelli, E.; Piandani, R.; Piccini, M.; Pontisso, L.; Rossetti, D.; Simula, F.; Sozzi, M.; Vicini, P. - 01a Articolo in rivista
rivista: NUCLEAR INSTRUMENTS & METHODS IN PHYSICS RESEARCH. SECTION A, ACCELERATORS, SPECTROMETERS, DETECTORS AND ASSOCIATED EQUIPMENT (Elsevier BV:PO Box 211, 1000 AE Amsterdam Netherlands:011 31 20 4853757, 011 31 20 4853642, 011 31 20 4853641, EMAIL: nlinfo-f@elsevier.nl, INTERNET: http://www.elsevier.nl, Fax: 011 31 20 4853598) pp. 115-118 - issn: 0168-9002 - wos: WOS:000418267300031 (1) - scopus: 2-s2.0-85013059129 (1)

11573/1353476 - 2017 - GPU real-time processing in NA62 trigger system
Ammendola, R.; Biagioni, A.; Chiozzi, S.; Cretaro, P.; Di Lorenzo, S.; Fantechi, R.; Fiorini, M.; Frezza, O.; Lamanna, G.; Lo Cicero, F.; Lonardo, A.; Martinelli, M.; Neri, I.; Paolucci, P. S.; Pastorelli, E.; Piandani, R.; Piccini, M.; Pontisso, L.; Rossetti, D.; Simula, F.; Sozzi, M.; Vicini, P. - 04c Atto di convegno in rivista
rivista: JOURNAL OF PHYSICS. CONFERENCE SERIES (Bristol : Institute of Physics Publishing) pp. - - issn: 1742-6588 - wos: WOS:000403471300046 (0) - scopus: 2-s2.0-85017255155 (0)
congresso: 10th International Conference on Kaon Physics, KAON 2016 (Birmingham; UK)

11573/1353470 - 2017 - Reconfigurable PCI Express cards for low-latency data transport in HEP experiments
Ammendola, R.; Biagioni, A.; Cretaro, P.; Frezza, O.; Lamanna, G.; Lo Cicero, F.; Lonardo, A.; Martinelli, M.; Paolucci, P. S.; Pastorelli, E.; Pontisso, L.; Simula, F.; Vicini, P. - 04c Atto di convegno in rivista
rivista: IL NUOVO CIMENTO C (Bologna: Società italiana di fisica) pp. - - issn: 2037-4909 - wos: WOS:000397330100065 (0) - scopus: 2-s2.0-85013831108 (0)
congresso: 15th Incontri di Fisica delle Alte Energie (IFAE 2016) (Genoa; Italy)

11573/1340386 - 2017 - Low latency network and distributed storage for next generation HPC systems: the ExaNeSt project
Ammendola, R.; Biagioni, A.; Cretaro, P.; Frezza, O.; Lo Cicero, F.; Lonardo, A.; Martinelli, M.; Paolucci, P. S.; Pastorelli, E.; Pisani, F.; Simula, F.; Vicini, P.; Navaridas, J.; Chaix, F.; Chrysos, N.; Katevenis, M.; Papaeustathiou, V. - 04c Atto di convegno in rivista
rivista: JOURNAL OF PHYSICS. CONFERENCE SERIES (Bristol : Institute of Physics Publishing) pp. - - issn: 1742-6588 - wos: (0) - scopus: 2-s2.0-85038426694 (1)
congresso: 22nd International Conference on Computing in High Energy and Nuclear Physics, CHEP 2016 (San Francisco; USA)

11573/1340366 - 2017 - Latest generation interconnect technologies in APEnet+ networking infrastructure
Ammendola, R.; Biagioni, A.; Cretaro, P.; Frezza, O.; Lo Cicero, F.; Lonardo, A.; Martinelli, M.; Paolucci, P. S.; Pastorelli, E.; Rossetti, D.; Simula, F.; Vicini, P. - 04c Atto di convegno in rivista
rivista: JOURNAL OF PHYSICS. CONFERENCE SERIES (Bristol : Institute of Physics Publishing) pp. - - issn: 1742-6588 - wos: (0) - scopus: 2-s2.0-85038439355 (1)
congresso: 22nd International Conference on Computing in High Energy and Nuclear Physics, CHEP 2016 (San Francisco; USA)

11573/1340380 - 2017 - The next generation of exascale-class systems: the ExaNeSt project
Ammendola, R.; Biagioni, A.; Cretaro, P.; Frezza, O.; Lo Cicero, F.; Lonardo, A.; Martinelli, M.; Paolucci, P. S.; Pastorelli, E.; Simula, F.; Vicini, P.; Taffoni, G.; Pascual, J. A.; Navaridas, J.; Lujan, M.; Goodacree, J.; Chrysos, N.; Katevenis, M. - 04b Atto di convegno in volume
congresso: 20th Euromicro Conference on Digital System Design, DSD 2017 (Vienna; Austria)
libro: Proceedings - 20th Euromicro Conference on Digital System Design, DSD 2017 - (978-1-5386-2146-2)

11573/1353352 - 2017 - Development of Network Interface Cards for TRIDAQ systems with the NaNet framework
Ammendola, R.; Biagioni, A.; Cretaro, P.; Lorenzo, S. D.; Fiorini, M.; Frezza, O.; Lamanna, G.; Cicero, F. L.; Lonardo, A.; Martinelli, M.; Neri, I.; Paolucci, P. S.; Pastorelli, E.; Piandani, R.; Pontisso, L.; Rossetti, D.; Simula, F.; Sozzi, M.; Valente, P.; Vicini, P. - 02a Capitolo o Articolo
congresso: Topical Workshop on Electronics for Particle Physics (TWEPP2016) (Karlsruhe (GERMANY))
libro: Topical Workshop on Electronics for Particle Physics (TWEPP2016) - ()

11573/1353454 - 2017 - Power-efficient computing: experiences from the COSA project
Cesini, D.; Corni, E.; Falabella, A.; Ferraro, A.; Morganti, L.; Calore, E.; Schifano, S. F.; Michelotto, M.; Alfieri, R.; De Pietri, R.; Boccali, T.; Biagioni, A.; Lo Cicero, F.; Lonardo, A.; Martinelli, M.; Paolucci, P. S.; Pastorelli, E.; Vicini, P. - 01a Articolo in rivista
rivista: SCIENTIFIC PROGRAMMING (IOS Press:Nieuwe Hemweg 6B, 1013 BG Amsterdam Netherlands:011 31 20 6883355, EMAIL: r.tosendjojo@iospress.nl, INTERNET: http://www.iospress.nl, Fax: 011 31 20 6203419 Precedente: New York: Wiley.) pp. - - issn: 1058-9244 - wos: WOS:000412552800001 (11) - scopus: 2-s2.0-85031899100 (13)

11573/1353509 - 2016 - GPU-based low-level trigger system for real-time Cherenkov ring fitting
Ammendola, R.; Biagioni, A.; Chiozzi, S.; Ramusino, A. C.; Fantechi, R.; Fiorini, M.; Frezza, O.; Gianoli, A.; Lamanna, G.; Cicero, F. L.; Lonardo, A.; Martinelli, M.; Neri, I.; Paolucci, P. S.; Pastorelli, E.; Piandani, R.; Piccini, M.; Pontisso, L.; Rossetti, D.; Santoni, C.; Simula, F.; Sozzi, M.; Tosoratto, L.; Vicini, P. - 04b Atto di convegno in volume
congresso: 2015 IEEE Nuclear Science Symposium and Medical Imaging Conference, NSS/MIC 2015 (San Diego, CA; USA)
libro: 2015 IEEE Nuclear Science Symposium and Medical Imaging Conference, NSS/MIC 2015 - (978-1-4673-9862-6)

11573/1353500 - 2016 - NaNet-10: a 10GbE network interface card for the GPU-based low-level trigger of the NA62 RICH detector
Ammendola, R.; Biagioni, A.; Fiorini, M.; Frezza, O.; Lonardo, A.; Lamanna, G.; Lo Cicero, F.; Martinelli, M.; Neri, I.; Paolucci, P. S.; Pastorelli, E.; Piandani, R.; Pontisso, L.; Rossetti, D.; Simula, F.; Sozzi, M.; Tosoratto, L.; Vicini, P. - 01a Articolo in rivista
rivista: JOURNAL OF INSTRUMENTATION (Bristol : IOP Publishing Ltd, 2006-) pp. - - issn: 1748-0221 - wos: WOS:000375746200031 (10) - scopus: 2-s2.0-84962034441 (12)

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