DANTE ROTILI

Associate professor


email: dante.rotili@uniroma1.it
phone: 3332749347
building: CU019
room: 206

PERSONAL INFORMATION
First name/Surname: Dante Rotili
EDUCATION AND TRAINING
June 4th, 2007, Ph.D. in Pharmaceutical Sciences, “Sapienza” University of Rome, Italy. Thesis Title: “Design, synthesis, biological evaluation, and structure-activity relationship of Uracil-Based HydroxyAmides (UBHAs) as a novel, highly potent class of HDAC inhibitors”, Pharmaceutical Studies Department, “Sapienza” University of Rome.
March 19th, 2003, Master’s Degree in Pharmaceutical Chemistry and Technology, “Sapienza” University of Rome. Mark: 110/110 cum laude. Thesis Title: “Phenylthiazolylcarboxyamides, a novel class of HIV-1 reverse transcriptase inhibitors”, Pharmaceutical Studies Department, “Sapienza” University of Rome.
POSITIONS AND EMPLOYMENT
Sep 2020 - present: Associate Professor of Medicinal Chemistry, “Sapienza” University of Rome.
Dec 2011 - Aug 2020: Tenured Researcher of Medicinal Chemistry, “Sapienza” University of Rome.
Sep 2010 - Nov 2011: Research Associate at the Department of Chemistry and Technology of Drugs, “Sapienza” University of Rome.
Apr 2009 - Sep 2010: Research Associate at the Department of Chemistry of the University of Oxford.
Jan 2007 - Mar 2009: Post-Doc fellow at the Department of Pharmaceutical Studies, “Sapienza” University of Rome.
RESEARCH TOPICS
Since 2003, the research activity of Prof. Rotili has been focusing mainly on the design and synthesis of modulators of epigenetic enzymes (histone deacetylases, acetyltransferases, methyltransferases and demethylases, sirtuins, and DNA methyltransferases and demethylases) as potential anticancer and/or antimicrobial agents. Other research topics are the development of HIV-1 reverse transcriptase inhibitors as antiviral agents, and of carbonic anhydrase (CA IX and XII), poly ADP-ribose polymerase (PARP1/2 and TNKS1/2) and glutathione-S-transferase inhibitors as potential anticancer and antiparasitic agents. Since 2009 Prof. Rotili has been also working for the development of chemo-proteomics probes for the functional characterization of various epigenetic and non-epigenetic targets. Finally, since 2015 Prof. Rotili has being involved in the development of radiotracers (both small molecules and radio-immunoconjugates) for tumor radio-guided surgery and of enhancers for cancer radiotherapy.
EDITORIAL ACTIVITY
From 2020 to date: Member of the Editorial Board of the journal Metabolites, Editor of the Section "Pharmacology and Drug Metabolism" (http: // https://www.mdpi.com/journal/metabolites/sectioneditors/pharmacology-drug-metabolism).
From 2018 to date: Member of the Editorial Board of the journal Annals of Nanoscience and Nanotechnology (http://www.remedypublications.com/annals-of-nanoscience-and-nanotechnology/).
REVIEWING ACTIVITY FOR FUNDING AGENCIES AND SCIENTIFIC JOURNALS
From Nov 2019 to date: Reviewer in the scientific evaluation committee of the Calls for Proposal "Biology and Basic Sciences for Cancer Research 2020-2022" organized by the National Institute for French Cancer Research (Institut National du Cancer, INCa).
Reviewer for the following scientific journals: ACS Med Chem Lett; J Med Chem, Eur J Med Chem, ChemMedChem, ChemBioChem, Bioorg Med Chem, J Enz Inhib Med Chem, Sci Rep, Molecules, Metabolites, Cancers, Int J Mol Sci, Pharmaceuticals, Cells, ACS Infect Dis, ACS Chem Biol, Cell Chem Biol, Front Oncol, Front Pharmacol.
AFFILIATION TO SCIENTIFIC SOCIETIES
From 2004 to date: Member of the Medicinal Chemistry Division of the Italian Chemical Society (ICS).
2010 - 2012: National Coordinator of the Youth Section of the Medicinal Chemistry Division of the Italian Chemical Society (ICS).
TEACHING ACTIVITY
From Academic Year 2022/2023 to date: Teaching of “Innovative approaches to drug discovery” (SSD CHIM / 08), Master's Degree Course in Pharmacy (6 CFU), “Sapienza” University of Rome.
From April 2022: Member of the teaching board of the PhD Course in “Molecular design and characterization for the promotion of health and well-being: from drug to food" starting from XXXVIII cycle, Academic Year 2022/2023.
From February 2022 to date: Coordinator of the International Degree Course in English "Molecular biology, Medicinal Chemistry and Computer Science for Pharmaceutical Applications".
From March 2019 to April 2022: Member of the teaching board of the PhD Course in "Pharmaceutical Sciences" starting from XXXV cycle, Academic Year 2019/2020.
From Academic Year 2013/2014 to date: Teaching of Pharmaceutical and Toxicological Chemical Analysis with Laboratory (SSD CHIM / 08), Master's Degree Course in Pharmacy, channel M-Z (12 CFU), “Sapienza” University of Rome.
SCIENTIFIC PRODUCTION
Prof. Rotili is author of more than one hundred fifty papers, more than fifty poster communications and more than ten oral presentations in national and international congresses.
PATENTS
1) International Patent Application PCT/IB2020/050105 entitled “RADIODRUG FOR DIAGNOSTIC/THERAPEUTIC USE IN NUCLEAR MEDICINE AND RADIO-GUIDED MEDICINE” by Faccini R, Solfaroli Camillocci E, Rotili D, Ciogli A, Cartoni A, Fratoddi I, Venditti I, Giordano A, Maccora D, Perotti G, Scotognella T.
2) Italian Granted Patent IT102019000000202 entitled “Radiofarmaco per utilizzo diagnostico terapeutico in medicina nucleare e medicina radio guidata” by Faccini R, Solfaroli Camillocci E, Rotili D, Ciogli A, Cartoni A, Fratoddi I, Venditti I, Giordano A, Maccora D, Perotti G, Scotognella T.
3) Granted Patent US20180118717 entitled "Substituted quinazoline derivatives as DNA methyltransferase inhibitors" by Halby L, Arimondo P, Mai A, Rotili D.
4) Patent Application WO2016/151144 A1 entitled "Substituted quinazoline derivatives as DNA methyl transferase inhibitors" by Halby L, Arimondo P, Mai A, Rotili D.
5) Italian Granted Patent IT0001412189 entitled "Preparation of 7-nitro-2,1,3-benzoxadiazole derivatives for antitumor therapy" by Caccuri AM, De Luca A, Federici L, Mai A, Rotili D.
HONORS AND AWARDS
1) 2011 Prize of the Italian Association of Pharmaceutical Companies Farmindustria for the Excellence in Medicinal Chemistry, reserved to scientists under 40 years old. 2) Prize “Sapienza Research 2011”, reserved to scientists under 40 years old. 3) Since July 2017 Italian Scientific National Habilitation to Full Professor of Medicinal Chemistry. 4) Recognition by the Editor-in-Chief of the Journal of Medicinal Chemistry of the article "Rotili D, Tomassi S, Conte M, Benedetti R, Tortorici M, Ciossani G, Valente S, Marrocco B, Labella D, Novellino E, Mattevi A, Altucci L, Tumber A, Yapp C, King ON, HopkinsonRJ, Kawamura A, Schofield CJ, Mai A. Pan-histone demethylase inhibitors simultaneously targeting jumonji C and lysine-specific demethylases display high anticancer activities. J. Med. Chem. 2014; 57: 42-55 "as HIGHLY CITED ARTICLE OF 2014. 4) Bentham Travel Grant for the participation to the XX International Symposium on Medicinal Chemistry (EFMC – ISMC 2008)” in Vienna.
AWARDED GRANTS
2022 to date: Principal investigator of the project “Addressing the catalytic and scaffolding functions of the histone lysine demethylase LSD1.” (Call of the "Sapienza" University of Rome - University projects 2022). Amount financed: € 11000,00.
2022 to date: Principal investigator of the project “Modulators of epigenetic targets for the treatment of parasitic diseases.” (Call of the "Sapienza" University of Rome - University projects 2021). Amount financed: € 14800,00.
2021 - 2022: Principal investigator of the project “Preclinical evaluation of 90Y labeled radiopharmaceutical for radio-guided surgery.” (Call of the Italian Ministry of Economic Development (MISE) - Program “Boosting Innovation Technology for Market Product Solutions - BIT4MaPS”). Amount financed: € 57000,00.
2021 - 2023: Responsible of the research unit of the "Sapienza" University of Rome within the project “Innovative 3D high content imaging methodologies for the validation of new anticancer molecules” (Call of the Regione Lazio, POR FESR Lazio 2014-2020). Amount financed: € 18123,00.
2019 - 2023: Principal investigator of the project “Development of glucose-based pure beta minus radiotracers potentially suitable for tumor radioguided surgery” (Call of the "Sapienza" University of Rome - University projects 2019). Amount financed: € 14500,00.
2018 - 2021: Principal investigator of the project “Development of novel LSD1 inhibitors as potential new generation anticancer agents”. (Call of the "Sapienza" University of Rome - University projects 2017). Amount financed: € 13500,00.
2016 - 2018: Principal investigator of the two-year TRIDEO 2015 project promoted by AIRC and Fondazione Cariplo Id. 17515, entitled "Toward a change of paradigm in tumor radioguided surgery: development of novel radiotracers exploiting pure beta minus decays." Amount financed: € 99550,00.
2015 - 2016: Principal investigator of the annual project "Design, synthesis and biological evaluation of novel DNA methyltransferase inhibitors" (Call of the "Sapienza" University of Rome - University AWARDS projects 2014; No. C26H148X4Y). Amount financed: € 53000,00.
2014 - 2017: Responsible of the research unit of the "Sapienza" University of Rome of the three-year project PRIN (Scientific Research Programs of Relevant National Interest) 2012 entitled "Search for new horizons in cancer treatment by integrating innovative drug-screening and rational drug design" (No. 2012CTAYSY_004). Amount financed: € 104629,00.
2014 - 2015: Principal investigator of the annual project ““Development of new series of sirtuin inhibitors” (Call of the "Sapienza" University of Rome - University projects 2013; No. C26A13SKF7). Amount financed: € 34946,04.
2013 - 2014: Principal investigator of the annual project “Novel Probes for Sirtuin Enzymes: A Medicinal Chemistry/Chemical Biology Approach” (Call of the "Sapienza" University of Rome - University projects 2012; No. C26A12Y7FB). Amount financed: € 40000,00.
TRACK-RECORD
(I) Scopus, update February 1st, 2023: H-index: 43; Total Citations: 5334.
(II) Google Scholar, update February 1st, 2023: H-index: 48; Total Citations: 6794.

Research products

11573/1673946 - 2023 - Role of SIRT3 in Microgravity Response: A New Player in Muscle Tissue Recovery
Aventaggiato, Michele; Barreca, Federica; Vitiello, Laura; Vespa, Simone; Valente, Sergio; Rotili, Dante; Mai, Antonello; Lotti, Lavinia Vittoria; Sansone, Luigi; Russo, Matteo A.; Bizzarri, Mariano; Ferretti, Elisabetta; Tafani, Marco - 01a Articolo in rivista
paper: CELLS (Basel: mdpi-Molecular Diversity Preservation International) pp. - - issn: 2073-4409 - wos: WOS:000947513100001 (1) - scopus: 2-s2.0-85149752388 (1)

11573/1674091 - 2023 - GreenMedChem- the challenge in the next decade toward eco-friendly compounds and processes in drug design
Castiello, Carola; Junghanns, Pierre; Mergel, Annika; Jacob, Claus; Ducho, Christian; Valente, Sergio; Rotili, Dante; Fioravanti, Rossella; Zwergel, Clemens; Mai, Antonello - 01g Articolo di rassegna (Review)
paper: GREEN CHEMISTRY (Royal Society of Chemistry:Thomas Graham House, Science Park, Cambridge CB4 0WF United Kingdom:011 44 1223 432360, EMAIL: sales@rsc.org, INTERNET: http://www.rsc.org, http://www.chensoc.org, Fax: 011 44 1223 423429) pp. 2109-2169 - issn: 1463-9262 - wos: WOS:000946579600001 (4) - scopus: 2-s2.0-85150432512 (4)

11573/1677023 - 2023 - Emerging Roles of SIRT5 in Metabolism, Cancer, and SARS-CoV-2 Infection
Fabbrizi, Emanuele; Fiorentino, Francesco; Carafa, Vincenzo; Altucci, Lucia; Mai, Antonello; Rotili, Dante - 01g Articolo di rassegna (Review)
paper: CELLS (Basel: mdpi-Molecular Diversity Preservation International) pp. 852- - issn: 2073-4409 - wos: WOS:000957394600001 (2) - scopus: 2-s2.0-85151108488 (3)

11573/1669898 - 2023 - Pyrimidine thioethers: A novel class of antidepressant agents, endowed with anxiolytic, performance enhancing and nootropic activity
Fioravanti, Rossella; Proia, Eleonora; Tyurenkov, Ivan N; Kurkin, Denis V; Bakulin, Dmitry A; Kovalev, Nikolay S; Sheikin, Dmitry S; Kirillov, Ivan A; Nawrozkij, Maxim B; Vernigora, Andrey A; Brunilina, Leila L; Fiorentino, Francesco; Mladenović, Milan; Rotili, Dante; Ragno, Rino - 01a Articolo in rivista
paper: EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY ([Paris] : Elsevier, [198?]-) pp. 114902- - issn: 1768-3254 - wos: WOS:000993134500001 (0) - scopus: 2-s2.0-85141941686 (0)

11573/1689870 - 2023 - The role of structural biology in the design of sirtuin activators
Fiorentino, Francesco; Mai, Antonello; Rotili, Dante - 01g Articolo di rassegna (Review)
paper: CURRENT OPINION IN STRUCTURAL BIOLOGY (Current Biology Limited:84 Theobalds Road, London WC1X 8RR United Kingdom:011 44 20 76114202, EMAIL: info@biomednet.com, INTERNET: http://www.biomednet.com, Fax: 011 44 20 76114479) pp. 102666- - issn: 0959-440X - wos: WOS:001057837700001 (0) - scopus: 2-s2.0-85169440750 (1)

11573/1669899 - 2023 - METTL3 from Target Validation to the First Small-Molecule Inhibitors: A Medicinal Chemistry Journey
Fiorentino, Francesco; Menna, Martina; Rotili, Dante; Valente, Sergio; Mai, Antonello - 01g Articolo di rassegna (Review)
paper: JOURNAL OF MEDICINAL CHEMISTRY (Washington DC : ACS Publications) pp. 1654-1677 - issn: 1520-4804 - wos: WOS:000932489700001 (9) - scopus: 2-s2.0-85147012551 (8)

11573/1677022 - 2023 - Antihistamines, phenothiazine-based antipsychotics, and tricyclic antidepressants potently activate pharmacologically relevant human carbonic anhydrase isoforms II and VII
Fiorentino, Francesco; Nocentini, Alessio; Rotili, Dante; Supuran, Claudiu T; Mai, Antonello - 01a Articolo in rivista
paper: JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY (Taylor & Francis Limited:Rankine Road, Basingstoke RG24 8PR United Kingdom:011 44 1256 813035, EMAIL: madeline.sims@tandf.co.uk, info@tandf.co.uk, INTERNET: http://www.tandf.co.uk, Fax: 011 44 1256 330245) pp. 2188147- - issn: 1475-6366 - wos: WOS:000949495200001 (3) - scopus: 2-s2.0-85150225921 (2)

11573/1677024 - 2023 - Native mass spectrometry-directed drug discovery: Recent advances in investigating protein function and modulation
Fiorentino, Francesco; Rotili, Dante; Mai, Antonello - 01g Articolo di rassegna (Review)
paper: DRUG DISCOVERY TODAY (Elsevier Science Limited Trends Journals:PO Box 331, Haywards Heath RH16 3FG United Kingdom:011 44 1444 475651, EMAIL: ct.subs@rbi.co.uk, Fax: 011 44 1444 445423) pp. 103548- - issn: 1359-6446 - wos: WOS:000955583400001 (3) - scopus: 2-s2.0-85150033652 (4)

11573/1681512 - 2023 - First-in-class selective inhibitors of the lysine acetyltransferase KAT8
Fiorentino, Francesco; Sementilli, Sara; Menna, Martina; Turrisi, Federica; Tomassi, Stefano; Pellegrini, Francesca Romana; Iuzzolino, Angela; D'acunzo, Francesca; Feoli, Alessandra; Wapenaar, Hannah; Taraglio, Sophie; Fraschetti, Caterina; Del Bufalo, Donatella; Sbardella, Gianluca; Dekker, Frank J.; Paiardini, Alessandro; Trisciuoglio, Daniela; Mai, Antonello; Rotili, Dante - 01a Articolo in rivista
paper: JOURNAL OF MEDICINAL CHEMISTRY (Washington DC : ACS Publications) pp. 6591-6616 - issn: 1520-4804 - wos: WOS:000988858800001 (0) - scopus: 2-s2.0-85159627845 (0)

11573/1669922 - 2023 - Simultaneous administration of EZH2 and BET inhibitors inhibits proliferation and clonogenic ability of metastatic prostate cancer cells
Negri, Aide; Marozzi, Marina; Trisciuoglio, Daniela; Rotili, Dante; Mai, Antonello; Rizzi, Federica - 01a Articolo in rivista
paper: JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY (Abingdon Oxfordshire United Kingdom: Taylor & Francis London: Gordon and Breach, 2002-) pp. 2163242- - issn: 1475-6374 - wos: WOS:000911853100001 (3) - scopus: 2-s2.0-85146193316 (2)

11573/1658358 - 2023 - Chemically diverse S. mansoni HDAC8 inhibitors reduced viability in worm larval and adult stages
Noce, Beatrice; Di Bello, Elisabetta; Zwergel, Clemens; Fioravanti, Rossella; Valente, Sergio; Rotili, Dante; Masotti, Andrea; Ansari, Mohammad Salik Zeya; Trisciuoglio, Daniela; Chakrabarti, Alokta; Romier, Christophe; Robaa, Dina; Sippl, Wolfgang; Jung, Manfred; Häberli, Cécile; Keiser, Jennifer; Mai, Antonello - 01a Articolo in rivista
paper: CHEMMEDCHEM (Weinheim : Wiley-VCH-Verl..) pp. - - issn: 1860-7179 - wos: WOS:000879912800001 (2) - scopus: 2-s2.0-85141693563 (2)

11573/1664753 - 2023 - Systematic Design of Adenosine Analogs as Inhibitors of a Clostridioides difficile-Specific DNA Adenine Methyltransferase Required for Normal Sporulation and Persistence
Zhou, Jujun; Horton, John R.; Menna, Martina; Fiorentino, Francesco; Ren, Ren; Yu, Dan; Hajian, Taraneh; Vedadi, Masoud; Mazzoccanti, Giulia; Ciogli, Alessia; Weinhold, Elmar; Hüben, Michael; Blumenthal, Robert M.; Zhang, Xing; Mai, Antonello; Rotili, Dante; Cheng, Xiaodong - 01a Articolo in rivista
paper: JOURNAL OF MEDICINAL CHEMISTRY (Washington, DC: American Chemical Society) pp. 934-950 - issn: 0022-2623 - wos: WOS:000907749800001 (1) - scopus: 2-s2.0-85145455635 (2)

11573/1684985 - 2023 - Novel 1,4-Dihydropyridines as Specific Binders and Activators of SIRT3 Impair Cell Viability and Clonogenicity and Downregulate Hypoxia-Induced Targets in Cancer Cells
Zwergel, Clemens; Aventaggiato, Michele; Garbo, Sabrina; Di Bello, Elisabetta; Fassari, Bruno; Noce, Beatrice; Castiello, Carola; Lambona, Chiara; Barreca, Federica; Rotili, Dante; Fioravanti, Rossella; Schmalz, Thomas; Weyand, Michael; Niedermeier, Amelie; Tripodi, Marco; Colotti, Gianni; Steegborn, Clemens; Battistelli, Cecilia; Tafani, Marco; Valente, Sergio; Mai, Antonello - 01a Articolo in rivista
paper: JOURNAL OF MEDICINAL CHEMISTRY (Washington, DC: American Chemical Society) pp. 9622-9641 - issn: 0022-2623 - wos: WOS:001027732800001 (0) - scopus: 2-s2.0-85165671509 (0)

11573/1661959 - 2022 - Pharmacological targeting of CBP/p300 drives a redox/autophagy axis leading to senescence-induced growth arrest in non-small cell lung cancer cells
Ansari, Mohammad Salik Zeya; Stagni, Venturina; Iuzzolino, Angela; Rotili, Dante; Mai, Antonello; Del Bufalo, Donatella; Lavia, Patrizia; Degrassi, Francesca; Trisciuoglio, Daniela - 01a Articolo in rivista
paper: CANCER GENE THERAPY (Nature Publishing Group:Brunel Road Houndmills, Basingstoke RG21 6XS United Kingdom:011 44 20 78334000, EMAIL: institutions@natureny.com, INTERNET: http://www.nature.com, Fax: 011 44 20 78434640) pp. 124-136 - issn: 0929-1903 - wos: WOS:000854955000001 (4) - scopus: 2-s2.0-85138300847 (3)

11573/1658360 - 2022 - Histone lysine demethylase inhibition reprograms prostate cancer metabolism and mechanics
Chianese, Ugo; Papulino, Chiara; Passaro, Eugenia; Evers, Tom Mj; Babaei, Mehrad; Toraldo, Antonella; De Marchi, Tommaso; Niméus, Emma; Carafa, Vincenzo; Nicoletti, Maria Maddalena; Del Gaudio, Nunzio; Iaccarino, Nunzia; Randazzo, Antonio; Rotili, Dante; Mai, Antonello; Cappabianca, Salvatore; Mashaghi, Alireza; Ciardiello, Fortunato; Altucci, Lucia; Benedetti, Rosaria - 01a Articolo in rivista
paper: MOLECULAR METABOLISM (Amsterdam : Elsevier) pp. 101561- - issn: 2212-8778 - wos: WOS:000844094200002 (2) - scopus: 2-s2.0-85136069603 (2)

11573/1618409 - 2022 - Multimodal evaluation of 19F-BPA internalization in pancreatic cancer cells for boron capture and proton therapy potential applications
Ciardiello, A.; Altierix, S.; Ballarini, F.; Bocci, V.; Bortolussi, S.; Cansolino, L.; Carlotti, D.; Ciocca, M.; Faccini, R.; Facoetti, A.; Ferrari, C.; Ficcadenti, L.; Furfaro, E.; Giagu, S.; Iacoangeli, F.; Macioce, G.; Mancini-Terracciano, C.; Messina, A.; Milazzo, L.; Pacifico, S.; Piccolella, S.; Postuma, I.; Rotili, D.; Vercesi, V.; Voena, C.; Vulcano, F.; Capuani, S. - 01a Articolo in rivista
paper: PHYSICA MEDICA (UK: Elsevier Pisa: Istituti Editoriali e Poligrafici Internazionali. Pisa Italy: Giardini Editori Stampatori) pp. 75-84 - issn: 1120-1797 - wos: WOS:000750944300002 (1) - scopus: 2-s2.0-85122230962 (2)

11573/1650772 - 2022 - Effects of Structurally Different HDAC Inhibitors against Trypanosoma cruzi, Leishmania, and Schistosoma mansoni
Di Bello, Elisabetta; Noce, Beatrice; Fioravanti, Rossella; Zwergel, Clemens; Valente, Sergio; Rotili, Dante; Fianco, Giulia; Trisciuoglio, Daniela; Mourão, Marina M; Sales, Policarpo; Lamotte, Suzanne; Prina, Eric; Späth, Gerald F; Häberli, Cécile; Keiser, Jennifer; Mai, Antonello - 01a Articolo in rivista
paper: ACS INFECTIOUS DISEASES (Washington, DC : American Chemical Society, 2015-) pp. 1356-1366-1366 - issn: 2373-8227 - wos: WOS:000819851400001 (10) - scopus: 2-s2.0-85134360722 (9)

11573/1657352 - 2022 - Therapeutic Potential and Activity Modulation of the Protein Lysine Deacylase Sirtuin 5
Fiorentino, F.; Castiello, C.; Mai, A.; Rotili, D. - 01g Articolo di rassegna (Review)
paper: JOURNAL OF MEDICINAL CHEMISTRY (Washington, DC: American Chemical Society) pp. 9580-9606 - issn: 0022-2623 - wos: WOS:000835071900001 (11) - scopus: 2-s2.0-85135378527 (10)

11573/1638052 - 2022 - Sirtuin modulators: past, present, and future perspectives
Fiorentino, Francesco; Mautone, Nicola; Menna, Martina; D'acunzo, Francesca; Mai, Antonello; Rotili, Dante - 01g Articolo di rassegna (Review)
paper: FUTURE MEDICINAL CHEMISTRY (London : Future Science, 2009-.) pp. - - issn: 1756-8919 - wos: WOS:000797024400001 (0) - scopus: 2-s2.0-85131771683 (0)

11573/1628944 - 2022 - Neuroprotective effects of PARP inhibitors in Drosophila models of Alzheimer’s disease
Maggiore, Anna; Casale, Assunta Maria; Toscanelli, Walter; Cappucci, Ugo; Rotili, Dante; Grieco, Maddalena; Gagné, Jean-Philippe; Poirier, Guy G.; D’Erme, Maria; Piacentini, Lucia - 01a Articolo in rivista
paper: CELLS (Basel: mdpi-Molecular Diversity Preservation International) pp. - - issn: 2073-4409 - wos: WOS:000786053000001 (5) - scopus: 2-s2.0-85127837219 (6)

11573/1635728 - 2022 - Novel non-covalent LSD1 inhibitors endowed with anticancer effects in leukemia and solid tumor cellular models
Menna, M.; Fiorentino, F.; Marrocco, B.; Lucidi, A.; Tomassi, S.; Cilli, D.; Romanenghi, M.; Cassandri, M.; Pomella, S.; Pezzella, M.; Del Bufalo, D.; Zeya Ansari, M. S.; Tomasevic, N.; Mladenovic, M.; Viviano, M.; Sbardella, G.; Rota, R.; Trisciuoglio, D.; Minucci, S.; Mattevi, A.; Rotili, D.; Mai, A. - 01a Articolo in rivista
paper: EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY (Editions Scientifique & Medical Elsevier:23 Rue Linois, F 75724 Paris Cedex 15 France:011 33 1 71724646, INTERNET: http://www.elsevier.fr, Fax: 011 33 1 71724664) pp. - - issn: 0223-5234 - wos: WOS:000804176200002 (9) - scopus: 2-s2.0-85129352278 (9)

11573/1613297 - 2022 - Transcriptomic and genomic studies classify NKL54 as a histone deacetylase inhibitor with indirect influence on MEF2-dependent transcription
Minisini, Martina; Di Giorgio, Eros; Kerschbamer, Emanuela; Dalla, Emiliano; Faggiani, Massimo; Franforte, Elisa; Meyer-Almes, Franz-Josef; Ragno, Rino; Antonini, Lorenzo; Mai, Antonello; Fiorentino, Francesco; Rotili, Dante; Chinellato, Monica; Perin, Stefano; Cendron, Laura; Weichenberger, Christian X; Angelini, Alessandro; Brancolini, Claudio - 01a Articolo in rivista
paper: NUCLEIC ACIDS RESEARCH (Oxford University Press:Journals Department, Great Clarendon Street, Oxford OX2 6DP United Kingdom:011 44 1865 556767, EMAIL: jnlorders@oup.co.uk, INTERNET: http://www.oup.co.uk, Fax: 011 44 1865 267485 Editore precedente: Information Retrieval ltd., London) pp. - - issn: 0305-1048 - wos: WOS:000764227300001 (5) - scopus: 2-s2.0-85127539205 (6)

11573/1622839 - 2022 - A potent HDAC inhibitor blocks Toxoplasma gondii tachyzoite growth and profoundly disrupts parasite gene expression
Mouveaux, T.; Rotili, D.; Boissavy, T.; Roger, E.; Pierrot, C.; Mai, A.; Gissot, M. - 01a Articolo in rivista
paper: INTERNATIONAL JOURNAL OF ANTIMICROBIAL AGENTS (Elsevier BV:PO Box 211, 1000 AE Amsterdam Netherlands:011 31 20 4853757, 011 31 20 4853642, 011 31 20 4853641, EMAIL: nlinfo-f@elsevier.nl, INTERNET: http://www.elsevier.nl, Fax: 011 31 20 4853598) pp. 106526- - issn: 0924-8579 - wos: WOS:000784446400008 (8) - scopus: 2-s2.0-85124124624 (7)

11573/1664310 - 2022 - Modulation of virulence-associated traits in Aspergillus fumigatus by BET Inhibitor JQ1
Orekhova, Anastasia; De Angelis, Marta; Cacciotti, Andrea; Reverberi, Massimo; Rotili, Dante; Giorgi, Alessandra; Protto, Virginia; Bonincontro, Graziana; Fiorentino, Francesco; Zgoda, Victor; Mai, Antonello; Palamara, Anna Teresa; Simonetti, Giovanna - 01a Articolo in rivista
paper: MICROORGANISMS (Basel : MDPI) pp. 1-19 - issn: 2076-2607 - wos: WOS:000895665300001 (0) - scopus: 2-s2.0-85144917834 (1)

11573/1541295 - 2022 - 90Y-DOTA-nimotuzumab: synthesis of a promising β⁻ radiopharmaceutical
Scotognella, T.; Maccora, D.; Bruno, I.; Chinol, M.; Castagnola, M.; Collamati, F.; Mancini-Terraciano, C.; Morganti, S.; Bocci, V.; Solfaroli-Camillocci, E.; Rotili, D; Cartoni, A; Fratoddi, I; Marini, F.; Venditti, I.; Faccini, R.; Giordano, A. - 01a Articolo in rivista
paper: CURRENT RADIOPHARMACEUTICALS (Bentham Science Publishers Ltd) pp. 32-39 - issn: 1874-4710 - wos: WOS:000808516000004 (1) - scopus: 2-s2.0-85127163927 (1)

11573/1622835 - 2022 - The Nitrobenzoxadiazole Derivative NBDHEX Behaves as Plasmodium falciparum Gametocyte Selective Inhibitor with Malaria Parasite Transmission Blocking Activity
Siciliano, G.; Di Paolo, V.; Rotili, D.; Migale, R.; Pedini, F.; Casella, M.; Camerini, S.; Dalzoppo, D.; Henderson, R.; Huijs, T.; Dechering, K. J.; Mai, A.; Caccuri, A. M.; Lalle, M.; Quintieri, L.; Alano, P. - 01a Articolo in rivista
paper: PHARMACEUTICALS (Basel : MDPI, Molecular Diversity Preservation International, 2004-) pp. 168- - issn: 1424-8247 - wos: WOS:000825152000002 (2) - scopus: 2-s2.0-85123900571 (2)

11573/1628559 - 2022 - Biochemical functions and clinical characterizations of the sirtuins in diabetes-induced retinal pathologies
Taurone, Samanta; De Ponte, Chiara; Rotili, Dante; De Santis, Elena; Mai, Antonello; Fiorentino, Francesco; Scarpa, Susanna; Artico, Marco; Micera, Alessandra - 01g Articolo di rassegna (Review)
paper: INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (Basel: MDPI Center) pp. - - issn: 1422-0067 - wos: WOS:000782009200001 (9) - scopus: 2-s2.0-85127570606 (9)

11573/1617428 - 2022 - Hydrophilic gold nanoparticles as Anti-PD-L1 antibody carriers. Synthesis and interface properties
Venditti, I.; Cartoni, A.; Cerra, S.; Fioravanti, R.; Salamone, T. A.; Sciubba, F.; Tabocchini, M. A.; Dini, V.; Battocchio, C.; Iucci, G.; Carlini, L.; Faccini, R.; Collamati, F.; Mancini T, C.; Solfaroli C, E.; Morganti, S.; Giordano, A.; Scotognella, T.; Maccora, D.; Rotili, D.; Marchese, C.; Anastasiadou, E.; Trivedi, P.; Fratoddi, I. - 01a Articolo in rivista
paper: PARTICLE & PARTICLE SYSTEMS CHARACTERIZATION (Wiley-VCH Verlag GmBH:PO Box 101161, D 69451 Weinheim Germany:011 49 6201 606147, EMAIL: service@wiley-vch.de, INTERNET: http://www.wiley-vch.de, Fax: 011 49 6201 606328) pp. 1-12 - issn: 0934-0866 - wos: WOS:000753440400001 (8) - scopus: 2-s2.0-85124617698 (9)

11573/1503800 - 2021 - Regulatory interplay between mir-181a-5p and estrogen receptor signaling cascade in breast cancer
Benedetti, R.; Papulino, C.; Sgueglia, G.; Chianese, U.; De Marchi, T.; Iovino, F.; Rotili, D.; Mai, A.; Nimeus, E.; Aversana, C. D.; Altucci, L. - 01a Articolo in rivista
paper: CANCERS (Basel : MDPI) pp. 1-19 - issn: 2072-6694 - wos: WOS:000614992800001 (8) - scopus: 2-s2.0-85100578967 (10)

11573/1541036 - 2021 - The two-faced role of sirt6 in cancer
Fiorentino, F.; Carafa, V.; Favale, G.; Altucci, L.; Mai, A.; Rotili, D. - 01g Articolo di rassegna (Review)
paper: CANCERS (Basel : MDPI) pp. 1-26 - issn: 2072-6694 - wos: WOS:000627939700001 (29) - scopus: 2-s2.0-85102076188 (29)

11573/1585511 - 2021 - Emerging Therapeutic Potential of SIRT6 Modulators
Fiorentino, F.; Mai, A.; Rotili, D. - 01g Articolo di rassegna (Review)
paper: JOURNAL OF MEDICINAL CHEMISTRY (Washington, DC: American Chemical Society) pp. 9732-9758 - issn: 0022-2623 - wos: WOS:000677581000007 (31) - scopus: 2-s2.0-85110981411 (31)

11573/1585447 - 2021 - Mass spectrometry enables the discovery of inhibitors of an LPS transport assembly via disruption of protein-protein interactions
Fiorentino, F.; Rotili, D.; Mai, A.; Bolla, J. R.; Robinson, C. V. - 01a Articolo in rivista
paper: CHEMICAL COMMUNICATIONS (Royal Society of Chemistry:Thomas Graham House, Science Park, Cambridge CB4 0WF United Kingdom:011 44 1223 432360, EMAIL: sales@rsc.org, INTERNET: http://www.rsc.org, http://www.chensoc.org, Fax: 011 44 1223 423429) pp. 10747-10750 - issn: 1359-7345 - wos: WOS:000700904000001 (4) - scopus: 2-s2.0-85117218452 (6)

11573/1585389 - 2021 - Anti-influenza A virus activity and structure–activity relationship of a series of nitrobenzoxadiazole derivatives
Fiorentino, Francesco; De Angelis, Marta; Menna, Martina; Rovere, Annarita; Maria Caccuri, Anna; D'acunzo, Francesca; Palamara, Anna Teresa; Nencioni, Lucia; Rotili, Dante; Mai, Antonello - 01a Articolo in rivista
paper: JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY (Taylor & Francis Limited:Rankine Road, Basingstoke RG24 8PR United Kingdom:011 44 1256 813035, EMAIL: madeline.sims@tandf.co.uk, info@tandf.co.uk, INTERNET: http://www.tandf.co.uk, Fax: 011 44 1256 330245) pp. 2128-2138 - issn: 1475-6366 - wos: WOS:000700847900001 (4) - scopus: 2-s2.0-85116047224 (3)

11573/1611281 - 2021 - Metabolic rewiring by loss of sirt5 promotes kras-induced pancreatic cancer progression
Hu, T.; Shukla, S. K.; Vernucci, E.; He, C.; Wang, D.; King, R. J.; Jha, K.; Siddhanta, K.; Mullen, N. J.; Attri, K. S.; Murthy, D.; Chaika, N. V.; Thakur, R.; Mulder, S. E.; Pacheco, C. G.; Fu, X.; High, R. R.; Yu, F.; Lazenby, A.; Steegborn, C.; Lan, P.; Mehla, K.; Rotili, D.; Chaudhary, S.; Valente, S.; Tafani, M.; Mai, A.; Auwerx, J.; Verdin, E.; Tuveson, D.; Singh, P. K. - 01a Articolo in rivista
paper: GASTROENTEROLOGY (USA: Elsevier Philadelphia, PA: W B Saunders Company) pp. 1584-1600 - issn: 0016-5085 - wos: WOS:000711484200002 (36) - scopus: 2-s2.0-85115084196 (38)

11573/1576703 - 2021 - Sirt5 inhibition induces brown fat-like phenotype in 3t3-l1 preadipocytes
Molinari, Francesca; Feraco, Alessandra; Mirabilii, Simone; Saladini, Serena; Sansone, Luigi; Vernucci, Enza; Tomaselli, Giada; Marzolla, Vincenzo; Rotili, Dante; A Russo, Matteo; Ricciardi, Maria Rosaria; Tafuri, Agostino; Mai, Antonello; Caprio, Massimiliano; Tafani, Marco; Armani, Andrea - 01a Articolo in rivista
paper: CELLS (Basel: mdpi-Molecular Diversity Preservation International) pp. 1-17 - issn: 2073-4409 - wos: WOS:000654660100001 (11) - scopus: 2-s2.0-85107437198 (11)

11573/1601697 - 2021 - First-in-Class Inhibitors of the Ribosomal Oxygenase MINA53
Nowak, R. P.; Tumber, A.; Hendrix, E.; Ansari, M. S. Z.; Sabatino, M.; Antonini, L.; Andrijes, R.; Salah, E.; Mautone, N.; Pellegrini, F. R.; Simelis, K.; Kawamura, A.; Johansson, C.; Passeri, D.; Pellicciari, R.; Ciogli, A.; Del Bufalo, D.; Ragno, R.; Coleman, M. L.; Trisciuoglio, D.; Mai, A.; Oppermann, U.; Schofield, C. J.; Rotili, D. - 01a Articolo in rivista
paper: JOURNAL OF MEDICINAL CHEMISTRY (Washington, DC: American Chemical Society) pp. 17031-17050 - issn: 0022-2623 - wos: WOS:000754727400006 (7) - scopus: 2-s2.0-85120646873 (7)

11573/1601812 - 2021 - JQ1, inibitore delle proteine BET, riduce i fattori di virulenza e la patogenicità di Aspergillus fumigatus.
Orekhova, A.; De Angelis, M.; Protto, V.; Rotili, D.; Mai, A.; A. T., Palamara.; Simonetti, G - 04d Abstract in atti di convegno
conference: Nome convegno (Napoli)
book: 13° Congresso Nazionale della Società Italiana di Microbiologia Farmaceutica Obiettivi e Sfide della Microbiologia Moderna per la Difesa della Salute - ()

11573/1408683 - 2020 - The pan-sirtuin inhibitor MC2494 regulates mitochondrial function in a leukemia cell line
Carafa, Vincenzo; Russo, Rosita; Della Torre, Laura; Cuomo, Francesca; Dell'aversana, Carmela; Sarno, Federica; Sgueglia, Giulia; Di Donato, Marzia; Rotili, Dante; Mai, Antonello; Nebbioso, Angela; Cobellis, Gilda; Chambery, Angela; Altucci, Lucia - 01a Articolo in rivista
paper: FRONTIERS IN ONCOLOGY (Lausanne : Frontiers Editorial Office, 2011-) pp. - - issn: 2234-943X - wos: WOS:000539644000001 (5) - scopus: 2-s2.0-85085984851 (5)

11573/1434640 - 2020 - CDK9 as a valuable target in cancer: from natural compounds inhibitors to current treatment in pediatric soft tissue sarcomas
Cassandri, Matteo; Fioravanti, Rossella; Pomella, Silvia; Valente, Sergio; Rotili, Dante; Del Baldo, Giada; De Angelis, Biagio; Rota, Rossella; Mai, Antonello - 01a Articolo in rivista
paper: FRONTIERS IN PHARMACOLOGY (Lausanne: Frontiers Media S.A., 2010-) pp. - - issn: 1663-9812 - wos: WOS:000565986100001 (17) - scopus: 2-s2.0-85089884656 (19)

11573/1387842 - 2020 - Radioguided surgery with β− radiation in pancreatic Neuroendocrine tumors: a feasibility study
Collamati, F.; Maccora, D.; Alfieri, S.; Bocci, V; Cartoni, A.; Collarino, A.; De Simoni, M.; Fischetti, M.; Fratoddi, I.; Giordano, A.; Mancini-Terracciano, C.; Mirabelli, R.; Morganti, S.; Quero, G.; Rotili, D.; Scotognella, T.; Solfaroli Camillocci, E.; Traini, G.; Venditti, I.; Faccini, R. - 01a Articolo in rivista
paper: SCIENTIFIC REPORTS (London: Springer Nature London: Nature Publishing Group) pp. - - issn: 2045-2322 - wos: WOS:000563275200010 (6) - scopus: 2-s2.0-85080868854 (7)

11573/1429750 - 2020 - Pharmacological inhibition of lysine-specific demethylase 1 (LSD1) induces global transcriptional deregulation and ultrastructural alterations that impair viability in Schistosoma mansoni
Coutinho Carneiro, V.; De Abreu Da Silva, I. C.; Amaral, M. S.; Pereira, A. S. A.; Silveira, G. O.; Pires, D. D. S.; Verjovski-Almeida, S.; Dekker, F. J.; Rotili, D.; Mai, A.; Lopes-Torres, E. J.; Robaa, D.; Sippl, W.; Pierce, R. J.; Borrello, M. T.; Ganesan, A.; Lancelot, J.; Thiengo, S.; Fernandez, M. A.; Vicentino, A. R. R.; Mourao, M. M.; Coelho, F. S.; Fantappie, M. R. - 01a Articolo in rivista
paper: PLOS NEGLECTED TROPICAL DISEASES (San Francisco, CA : Public Library of Science) pp. - - issn: 1935-2735 - wos: WOS:000547527200003 (7) - scopus: 2-s2.0-85087471659 (6)

11573/1429748 - 2020 - Characterization of water-soluble esters of nitrobenzoxadiazole-based GSTP1-1 inhibitors for cancer treatment
Di Paolo, V.; Fulci, C.; Rotili, D.; De Luca, A.; Tomassi, S.; Serra, M.; Scimeca, M.; Geroni, C.; Quintieri, L.; Caccuri, A. M. - 01a Articolo in rivista
paper: BIOCHEMICAL PHARMACOLOGY (-Oxford, United Kingdom: Elsevier Science Limited -London ; New York : Pergamon Press, 1958-) pp. 114060- - issn: 0006-2952 - wos: WOS:000551658300022 (5) - scopus: 2-s2.0-85086125526 (5)

11573/1382315 - 2020 - Tranylcypromine-based LSD1 inhibitors: structure-activity relationships, antiproliferative effects in leukemia, and gene target modulation
Fioravanti, R.; Romanelli, A.; Mautone, N.; Di Bello, E.; Rovere, A.; Corinti, D.; Zwergel, C.; Valente, S.; Rotili, D.; Botrugno, O. A.; Dessanti, P.; Vultaggio, S.; Vianello, P.; Cappa, A.; Binda, C.; Mattevi, A.; Minucci, S.; Mercurio, C.; Varasi, M.; Mai, A. - 01a Articolo in rivista
paper: CHEMMEDCHEM (Weinheim : Wiley-VCH-Verl..) pp. 643-658 - issn: 1860-7179 - wos: WOS:000513271600001 (16) - scopus: 2-s2.0-85079446800 (15)

11573/1425034 - 2020 - Targeting histone acetylation/deacetylation in parasites: an update (2017–2020)
Fioravanti, Rossella; Mautone, Nicola; Rovere, Annarita; Rotili, Dante; Mai, Antonello - 01g Articolo di rassegna (Review)
paper: CURRENT OPINION IN CHEMICAL BIOLOGY (Current Biology Limited:84 Theobalds Road, London WC1X 8RR United Kingdom:011 44 20 76114202, EMAIL: info@biomednet.com, INTERNET: http://www.biomednet.com, Fax: 011 44 20 76114479) pp. 65-74 - issn: 1367-5931 - wos: WOS:000568781700011 (32) - scopus: 2-s2.0-85086940284 (30)

11573/1585515 - 2020 - Lysine Acetyltransferase Inhibitors From Natural Sources
Fiorentino, F.; Mai, A.; Rotili, D. - 01g Articolo di rassegna (Review)
paper: FRONTIERS IN PHARMACOLOGY (Lausanne: Frontiers Media S.A., 2010-) pp. 1243- - issn: 1663-9812 - wos: WOS:000565346900001 (16) - scopus: 2-s2.0-85089907540 (19)

11573/1585513 - 2020 - HAT inhibitors in cancer therapy
Fiorentino, Francesco; Mai, Antonello; Rotili, Dante - 02a Capitolo o Articolo
book: Histone Modifications in Therapy - (9780128164228)

11573/1401342 - 2020 - Identification of Inhibitors to trypanosoma cruzi sirtuins based on compounds developed to human enzymes
Matutino Bastos, Tanira; Botelho Pereira Soares, Milena; Haddad Franco, Caio; Alcântara, Laura; Antonini, Lorenzo; Sabatino, Manuela; Mautone, Nicola; Holanda Freitas-Junior, Lucio; Moraes, Carolina Borsoi; Ragno, Rino; Rotili, Dante; Schenkman, Sergio; Mai, Antonello; Silvio Moretti, Nilmar - 01a Articolo in rivista
paper: INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (Basel: MDPI Center) pp. - - issn: 1422-0067 - wos: WOS:000539312100255 (8) - scopus: 2-s2.0-85085293622 (8)

11573/1384850 - 2020 - Sirtuin modulators: where are we now? A review of patents from 2015 to 2019
Mautone, Nicola; Zwergel, Clemens; Mai, Antonello; Rotili, Dante - 01g Articolo di rassegna (Review)
paper: EXPERT OPINION ON THERAPEUTIC PATENTS (--London United Kingdom:Informa Healthcare -London, United Kingdom: Ashley Publications Limited) pp. - - issn: 1354-3776 - wos: WOS:000526337100001 (35) - scopus: 2-s2.0-85083571564 (35)

11573/1480930 - 2020 - Recent advances in epigenetic proteolysis targeting chimeras (Epi-PROTACs)
Tomaselli, D.; Mautone, N.; Mai, A.; Rotili, D. - 01g Articolo di rassegna (Review)
paper: EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY (Editions Scientifique & Medical Elsevier:23 Rue Linois, F 75724 Paris Cedex 15 France:011 33 1 71724646, INTERNET: http://www.elsevier.fr, Fax: 011 33 1 71724664) pp. - - issn: 0223-5234 - wos: WOS:000591227400031 (11) - scopus: 2-s2.0-85089918812 (12)

11573/1408685 - 2020 - Sirt4: a multifaceted enzyme at the crossroads of mitochondrial metabolism and cancer
Tomaselli, D.; Steegborn, C.; Mai, A.; Rotili, D. - 01g Articolo di rassegna (Review)
paper: FRONTIERS IN ONCOLOGY (Lausanne : Frontiers Editorial Office, 2011-) pp. - - issn: 2234-943X - wos: WOS:000531334700001 (36) - scopus: 2-s2.0-85083986337 (38)

11573/1389775 - 2020 - From parp1 to tnks2 Inhibition: a structure-based approach
Tomassi, Stefano; Pfahler, Julian; Mautone, Nicola; Rovere, Annarita; Esposito, Chiara; Passeri, Daniela; Pellicciari, Roberto; Novellino, Ettore; Pannek, Martin; Steegborn, Clemens; Paiardini, Alessandro; Mai, Antonello; Rotili, Dante - 01a Articolo in rivista
paper: ACS MEDICINAL CHEMISTRY LETTERS (USA: ACS Publications) pp. - - issn: 1948-5875 - wos: WOS:000535281200039 (8) - scopus: 2-s2.0-85087107488 (8)

11573/1355613 - 2019 - H19-dependent transcriptional regulation of β3 and β4 integrins upon estrogen and hypoxia favors metastatic potential in prostate cancer
Bacci, L.; Aiello, A.; Ripoli, C.; Loria, R.; Pugliese, D.; Pierconti, F.; Rotili, D.; Strigari, L.; Pinto, F.; Bassi, P. F.; Mai, A.; Grassi, C.; Pontecorvi, A.; Falcioni, R.; Farsetti, A.; Nanni, S. - 01a Articolo in rivista
paper: INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (Basel (Matthaeustrasse 11) : Molecular Diversity Preservation International MDPI) pp. - - issn: 1661-6596 - wos: WOS:000484411100169 (20) - scopus: 2-s2.0-85071378179 (19)

11573/1355598 - 2019 - Inhibition of histone demethylases LSD1 and UTX regulates ERα signaling in breast cancer
Benedetti, R.; Dell'aversana, C.; De Marchi, T.; Rotili, D.; Liu, N. Q.; Novakovic, B.; Boccella, S.; Di Maro, S.; Cosconati, S.; Baldi, A.; Nimeus, E.; Schultz, J.; Hoglund, U.; Maione, S.; Papulino, C.; Chianese, U.; Iovino, F.; Federico, A.; Mai, A.; Stunnenberg, H. G.; Nebbioso, A.; Altucci, L. - 01a Articolo in rivista
paper: CANCERS (Basel : MDPI) pp. - - issn: 2072-6694 - wos: WOS:000507382100204 (25) - scopus: 2-s2.0-85077269849 (28)

11573/1193778 - 2019 - Identification of novel quinazoline derivatives as potent antiplasmodial agents
Bouchut, A; Rotili, D; Pierrot, C; Valente, S; Lafitte, S; Schultz, J; Hoglund, U; Mazzone, R; Lucidi, A; Fabrizi, G; Pechalrieu, D; Arimondo, Pb; Skinner-Adams, Ts; Chua, Mj; Andrews, Kt; Mai, A; Khalife, J. - 01a Articolo in rivista
paper: EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY (Editions Scientifique & Medical Elsevier:23 Rue Linois, F 75724 Paris Cedex 15 France:011 33 1 71724646, INTERNET: http://www.elsevier.fr, Fax: 011 33 1 71724664) pp. 277-291 - issn: 0223-5234 - wos: WOS:000451498200018 (38) - scopus: 2-s2.0-85055197167 (40)

11573/1336693 - 2019 - Enzymatic and biological characterization of novel sirtuin modulators against cancer
Carafa, V.; Poziello, A.; Torre, L. D.; Giovannelli, P.; Di Donato, M.; Safadeh, E.; Yu, Z.; Baldi, A.; Castoria, G.; Tomaselli, D.; Mai, A.; Rotili, D.; Nebbioso, A.; Altucci, L. - 01a Articolo in rivista
paper: INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (Basel (Matthaeustrasse 11) : Molecular Diversity Preservation International MDPI) pp. - - issn: 1661-6596 - wos: WOS:000502786800136 (8) - scopus: 2-s2.0-85074828780 (10)

11573/1355615 - 2019 - Synthesis and characterisation of a new benzamide-containing nitrobenzoxadiazole as a GSTP1-1 inhibitor endowed with high stability to metabolic hydrolysis
Di Paolo, V.; Fulci, C.; Rotili, D.; Sciarretta, F.; Lucidi, A.; Morozzo Della Rocca, B.; De Luca, A.; Rosato, A.; Quintieri, L.; Caccuri, A. M. - 01a Articolo in rivista
paper: JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY (Taylor & Francis Limited:Rankine Road, Basingstoke RG24 8PR United Kingdom:011 44 1256 813035, EMAIL: madeline.sims@tandf.co.uk, info@tandf.co.uk, INTERNET: http://www.tandf.co.uk, Fax: 011 44 1256 330245) pp. 1131-1139 - issn: 1475-6366 - wos: WOS:000476871200001 (7) - scopus: 2-s2.0-85067475804 (8)

11573/1336760 - 2019 - DNA Methylation: Biological Implications and Modulation of Its Aberrant Dysregulation
Lucidi, Alessia; Tomaselli, Daniela; Rotili, Dante; Mai, Antonello - 02a Capitolo o Articolo
book: The DNA, RNA, and Histone Methylomes - (978-3-030-14791-4; 978-3-030-14792-1)

11573/1306441 - 2019 - Gold nanoparticles and nanorods in nuclear medicine: a mini review
Maccora, Daria; Dini, Valentina; Battocchio, Chiara; Fratoddi, Ilaria; Cartoni, Antonella; Rotili, Dante; Castagnola, Massimo; Faccini, Riccardo; Bruno, Isabella; Scotognella, Teresa; Giordano, Alessandro; Venditti, Iole - 01g Articolo di rassegna (Review)
paper: APPLIED SCIENCES (Basel: MDPI AG, 2011-) pp. - - issn: 2076-3417 - wos: WOS:000484444100026 (38) - scopus: 2-s2.0-85071043073 (43)

11573/1336715 - 2019 - Structure-reactivity relationships on substrates and inhibitors of the lysine deacylase sirtuin 2 from schistosoma mansoni (SmSirt2)
Monaldi, Daria; Rotili, Dante; Julien Lancelot, ‡; Martin Marek, §; Nathalie Wössner, ∥; Lucidi, Alessia; Tomaselli, Daniela; Elizabeth Ramos-Morales, ‡; Christophe Romier, ∥; Pierce, ∥ Raymond J.; Mai, Antonello; And Manfred Jung, ‡ - 01a Articolo in rivista
paper: JOURNAL OF MEDICINAL CHEMISTRY (Washington, DC: American Chemical Society) pp. 8733-8759 - issn: 0022-2623 - wos: WOS:000490355000005 (16) - scopus: 2-s2.0-85072924967 (15)

11573/1221842 - 2019 - Effect of α-methoxy substitution on the anti-HIV activity of dihydropyrimidin-4(3 H)-ones
Nawrozkij, Maxim B.; Forgione, Mariantonietta; Yablokov, Alexandre S.; Lucidi, Alessia; Tomaselli, Daniela; Patsilinakos, Alexandros; Panella, Cristina; Hailu, Gebremedhin S.; Kirillov, Ivan A.; Badia, Roger; Riveira-Munoz, Eva; Crespan, Emmanuele; Armijos Rivera, Jorge I.; Cirilli, Roberto; Ragno, Rino; Esté, José A.; Maga, Giovanni; Mai, Antonello; Rotili, Dante - 01a Articolo in rivista
paper: JOURNAL OF MEDICINAL CHEMISTRY (Washington, DC: American Chemical Society) pp. 604-621 - issn: 0022-2623 - wos: WOS:000457067600015 (14) - scopus: 2-s2.0-85059424455 (12)

11573/1336742 - 2019 - α,γ-Diketocarboxylic acids and their esters act as carbonic anhydrase IX and XII selective inhibitors
Nocentini, Alessio; Lucidi, Alessia; Perut, Francesca; Massa, Annamaria; Tomaselli, Daniela; Gratteri, Paola; Baldini, Nicola; Rotili, Dante; Mai, Antonello; Supuran, Claudiu T. - 01a Articolo in rivista
paper: ACS MEDICINAL CHEMISTRY LETTERS (USA: ACS Publications) pp. 661-665 - issn: 1948-5875 - wos: WOS:000464767700047 (16) - scopus: 2-s2.0-85064255109 (17)

11573/1339733 - 2019 - Epigenetic modulators as a new strategies to reduce Aspergillus pathogenicity
Orekhova, Anastasia; D’Auria, F. D.; Rotili, D.; Mai, A.; Palamara, A. T.; Simonetti, G - 04f Poster
conference: 47° Congresso Nazionale della Società Italiana di Microbiologia (Roma)
book: 47° Congresso Nazionale della Società Italiana di Microbiologia - ()

11573/1355611 - 2019 - Effects of glutathione transferase-targeting nitrobenzoxadiazole compounds in relation to PD-L1 status in human melanoma cells
Sciarretta, F.; Fulci, C.; Palumbo, C.; Rotili, D.; Tentori, L.; Graziani, G.; Caccuri, A. M. - 01a Articolo in rivista
paper: CHEMOTHERAPY (S Karger AG:Allschwilerstrasse 10, CH-4009 Basel Switzerland:011 41 61 3061111, EMAIL: orders@karger.ch, INTERNET: http://www.karger.com, Fax: 011 41 61 3061234) pp. 138-145 - issn: 0009-3157 - wos: WOS:000501814700004 (3) - scopus: 2-s2.0-85074343924 (3)

11573/1355609 - 2019 - Comparison of the effects of synthetic and plant-derived mTOR regulators on healthy human ovarian cells
Sirotkin, A. V.; Adamcova, E.; Rotili, D.; Mai, A.; Mlyncek, M.; Mansour, L.; Alwasel, S.; Harrath, A. H. - 01a Articolo in rivista
paper: EUROPEAN JOURNAL OF PHARMACOLOGY (AMSTERDAM, NETHERLANDS: ELSEVIER SCIENCE) pp. 70-78 - issn: 0014-2999 - wos: WOS:000468305200009 (1) - scopus: 2-s2.0-85063965408 (2)

11573/1336730 - 2019 - Epigenetic polypharmacology: a new frontier for epi-drug discovery
Tomaselli, Daniela; Lucidi, Alessia; Rotili, Dante; Mai, Antonello - 01g Articolo di rassegna (Review)
paper: MEDICINAL RESEARCH REVIEWS ([New York, N.Y.] : Wiley) pp. 190-244 - issn: 1098-1128 - wos: WOS:000534635500009 (60) - scopus: 2-s2.0-85075138650 (68)

11573/1355619 - 2019 - Histone Acetyltransferase Enzymes: From Biological Implications to Most Relevant Inhibitors
Trisciuoglio, Daniela; Rotili, Dante - 02a Capitolo o Articolo
book: Topics in medicinal chemistry - ()

11573/1355602 - 2019 - Histone deacetylase inhibitors exert anti-tumor effects on human adherent and stem-like glioma cells 11 Medical and Health Sciences 1112 Oncology and Carcinogenesis
Was, H.; Krol, S. K.; Rotili, D.; Mai, A.; Wojtas, B.; Kaminska, B.; Maleszewska, M. - 01a Articolo in rivista
paper: CLINICAL EPIGENETICS (Berlin : Springer) pp. 11- - issn: 1868-7083 - wos: WOS:000456005400002 (45) - scopus: 2-s2.0-85060173887 (42)

11573/1275422 - 2019 - Sirtuins as drug targets
Zwergel, Clemens; Rotili, Dante; Valente, Sergio; Mai, Antonello - 02a Capitolo o Articolo
book: Epigenetic Drug Discovery - (9783527343140; 9783527809257)

11573/1116555 - 2018 - RIP1-HAT1-SirT complex identification and targeting in treatment and prevention of cancer
Carafa, Vincenzo; Nebbioso, Angela; Cuomo, Francesca; Rotili, Dante; Cobellis, Gilda; Bontempo, Paola; Baldi, Alfonso; Spugnini, Enrico P.; Citro, Alfonso Gennaro; Chambery, Angela; Russo, Rosita; Ciana, Paolo; Maravigna, Luca; Shaik, Jani; Radaelli, Enrico; De Antonellis, Pasquale; Tarantino, Domenico; Pirolli, Adele; Ragno, Rino; Massimo Zollo, .; Stunnenberg, Hendrik G.; Mai, Antonello; Altucci, Lucia - 01a Articolo in rivista
paper: CLINICAL CANCER RESEARCH (American Association of Cancer Research:150 South Independence Mall West, #826:Philadelphia, PA 19106:(215)440-9300, EMAIL: pubs@aacr.org, INTERNET: http://www.aacr.org, Fax: (215)440-7228) pp. 2886-2900 - issn: 1078-0432 - wos: WOS:000435462700019 (32) - scopus: 2-s2.0-85052287980 (34)

11573/1115449 - 2018 - KAT3B-p300 and H3AcK18/H3AcK14 levels are prognostic markers for kidney ccRCC tumor aggressiveness and target of KAT inhibitor CPTH2
Cocco, Elisa; Leo, Manuela; Canzonetta, Claudia; Di Vito, Serena; Mai, Antonello; Rotili, Dante; Di Napoli, Arianna; Vecchione, Andrea; De Nunzio, Cosimo; Filetici, Patrizia; Stoppacciaro, Antonella - 01a Articolo in rivista
paper: CLINICAL EPIGENETICS (Berlin : Springer) pp. 1-16 - issn: 1868-7083 - wos: WOS:000429840100001 (9) - scopus: 2-s2.0-85045003305 (10)

11573/1147231 - 2018 - Lysine acetyltransferase inhibitors: structure-activity relationships and potential therapeutic implications
Fiorentino, Francesco; Mai, Antonello; Rotili, Dante - 01a Articolo in rivista
paper: FUTURE MEDICINAL CHEMISTRY (London : Future Science, 2009-.) pp. 1067-1091 - issn: 1756-8919 - wos: WOS:000431874300008 (24) - scopus: 2-s2.0-85046873546 (23)

11573/1174039 - 2018 - Pharmacological activation of SIRT6 triggers lethal autophagy in human cancer cells
Iachettini, Sara; Trisciuoglio, Daniela; Rotili, Dante; Lucidi, Alessia; Salvati, Erica; Zizza, Pasquale; Di Leo, Luca; Del Bufalo, Donatella; Rosa Ciriolo, Maria; Leonetti, Carlo; Steegborn, Clemens; Mai, Antonello; Rizzo, Angela; Annamaria Biroccio, And - 01a Articolo in rivista
paper: CELL DEATH & DISEASE (Nature Group) pp. 996- - issn: 2041-4889 - wos: WOS:000446267200026 (59) - scopus: 2-s2.0-85053859793 (64)

11573/1118719 - 2018 - Mass spectrometry characterization of DOTA-Nimotuzumab conjugate as precursor of an innovative β − tracer suitable in radio-guided surgery
Martelli, C.; Marzano, V.; Marini, F.; Scotognella, T.; Fratoddi, I.; Venditti, I; Rotili, D.; Solfaroli C., E.; Collamati, F.; Mancini T., C.; Morganti, S.; Maccora, D.; Faccini, R.; Cartoni, A; Giordano, A.; Castagnola, M. - 01a Articolo in rivista
paper: JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS (Oxford ; New York : Pergamon Press Amsterdam : Elsevier Science) pp. 8-15 - issn: 0731-7085 - wos: WOS:000435228400002 (4) - scopus: 2-s2.0-85046479862 (5)

11573/1065694 - 2018 - Disruptor of telomeric silencing 1-like (DOT1L): disclosing a new class of non-nucleoside inhibitors by means of ligand-based and structure-based approaches
Sabatino, Manuela; Rotili, Dante; Patsilinakos, Alexandros; Forgione, Mariantonietta; Tomaselli, Daniela; Alby, Fréderic; Arimondo, Paola B.; Mai, Antonello; Ragno, Rino - 01a Articolo in rivista
paper: JOURNAL OF COMPUTER-AIDED MOLECULAR DESIGN (-SPRINGER, VAN GODEWIJCKSTRAAT 30, DORDRECHT, NETHERLANDS, 3311 GZ -Kluwer Academic Publishers:Journals Department, PO Box 322, 3300 AH Dordrecht Netherlands:011 31 78 6576050, EMAIL: frontoffice@wkap.nl, kluweronline@wkap.nl, INTERNET: http://www.kluwerlaw.com, Fax: 011 31 78 6576254) pp. 435-458 - issn: 0920-654X - wos: WOS:000425293300003 (16) - scopus: 2-s2.0-85041359880 (15)

11573/1602341 - 2017 - Corrigendum: Selective targeting of HDAC1/2 elicits anticancer effects through Gli1 acetylation in preclinical models of SHH Medulloblastoma
Coni, S.; Mancuso, A. B.; Di Magno, L.; Sdruscia, G.; Manni, S.; Serrao, S. M.; Rotili, D.; Spiombi, E.; Bufalieri, F.; Petroni, M.; Kusio-Kobialka, M.; De Smaele, E.; Ferretti, E.; Capalbo, C.; Mai, A.; Niewiadomski, P.; Screpanti, I.; Di Marcotullio, L.; Canettieri, G. - 01b Commento, Erratum, Replica e simili
paper: SCIENTIFIC REPORTS (London: Springer Nature London: Nature Publishing Group) pp. - - issn: 2045-2322 - wos: WOS:000399974300001 (5) - scopus: 2-s2.0-85068766477 (4)

11573/946157 - 2017 - Selective targeting of HDAC1/2 elicits anticancer effects through Gli1 acetylation in preclinical models of SHH Medulloblastoma.
Coni, Sonia; Mancuso, Anna Barbara; Di Magno, L; Sdruscia, Giulia; Manni, Simona; Serrao, Silvia Maria; Rotili, Dante; Spiombi, Eleonora; Bufalieri, Francesca; Petroni, Marialaura; Kusio Kobialka, M; De Smaele, Enrico; Ferretti, Elisabetta; Capalbo, Carlo; Mai, Antonello; Niewiadomski, P; Screpanti, Isabella; Di Marcotullio, Lucia; Canettieri, Gianluca - 01a Articolo in rivista
paper: SCIENTIFIC REPORTS (London: Springer Nature London: Nature Publishing Group) pp. 44079- - issn: 2045-2322 - wos: WOS:000396136700001 (53) - scopus: 2-s2.0-85014895304 (51)

11573/944093 - 2017 - The nitrobenzoxadiazole derivative MC3181 blocks melanoma invasion and metastasis.
De Luca, A; Carpanese, D; Rapanotti, Mc; Viguria, Tm; Forgione, Ma; Rotili, Dante; Fulci, C; Iorio, E; Quintieri, L; Chimenti, S; Bianchi, L; Rosato, A; Caccuri, A. M. 1. - 01a Articolo in rivista
paper: ONCOTARGET (Albany, N.Y. : Impact Journals) pp. 15520-15538 - issn: 1949-2553 - wos: WOS:000396013700106 (17) - scopus: 2-s2.0-85014078650 (17)

11573/944092 - 2017 - A new nitrobenzoxadiazole-based GSTP1-1 inhibitor with a previously unheard of mechanism of action and high stability.
Fulci, C; Rotili, Dante; De Luca, A; Stella, L; Morozzo Della Rocca, B; Forgione, M; Di Paolo, V; Mai, Antonello; Falconi, M; Quintieri, L; Caccuri, Am; 7, . - 01a Articolo in rivista
paper: JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY (Taylor & Francis Limited:Rankine Road, Basingstoke RG24 8PR United Kingdom:011 44 1256 813035, EMAIL: madeline.sims@tandf.co.uk, info@tandf.co.uk, INTERNET: http://www.tandf.co.uk, Fax: 011 44 1256 330245) pp. 240-247 - issn: 1475-6366 - wos: WOS:000392591100017 (16) - scopus: 2-s2.0-85015590345 (16)

11573/1027812 - 2017 - Lysine deacetylase inhibitors in parasites: past, present, and future perspectives.
Hailu, Gs; Robaa, D; Forgione, M; Sippl, W; Rotili, D; Mai, A. - 01a Articolo in rivista
paper: JOURNAL OF MEDICINAL CHEMISTRY (Washington, DC: American Chemical Society) pp. 4780-4804 - issn: 0022-2623 - wos: WOS:000404202200002 (64) - scopus: 2-s2.0-85021131721 (65)

11573/1027154 - 2017 - Feasibility of beta-particle radioguided surgery for a variety of “nuclear medicine” radionuclides
Mancini Terracciano, C; Donnarumma, R; Bencivenga, G.; Bocci, V.; Cartoni, A.; Collamati, F.; Fratoddi, I.; Giordano, A.; Indovina, L.; Maccora, D.; Marafini, M.; Mirabelli, R.; Morganti, S.; Rotili, D.; Russomando, A.; Scotognella, T.; Solfaroli C, E.; Toppi, M; Traini, G.; Venditti, I.; Faccini, R. - 01a Articolo in rivista
paper: PHYSICA MEDICA (UK: Elsevier Pisa: Istituti Editoriali e Poligrafici Internazionali. Pisa Italy: Giardini Editori Stampatori) pp. 127-133 - issn: 1120-1797 - wos: WOS:000417655800016 (20) - scopus: 2-s2.0-85036555361 (22)

11573/947675 - 2017 - Development of 1,2,4-oxadiazoles as potent and selective inhibitors of the human deacetylase sirtuin 2: structure-activity relationship, X-ray crystal structure, and anticancer activity
Moniot, S; Forgione, M; Lucidi, Alessia; Hailu, Gebremedhin Solomon; Nebbioso, A; Carafa, V; Baratta, F; Altucci, L; Giacché, N; Passeri, D; Pellicciari, R; Mai, Antonello; Steegborn, C; Rotili, Dante - 01a Articolo in rivista
paper: JOURNAL OF MEDICINAL CHEMISTRY (Washington, DC: American Chemical Society) pp. 2344-2360 - issn: 0022-2623 - wos: WOS:000397546000013 (69) - scopus: 2-s2.0-85016147565 (72)

11573/944090 - 2017 - Towards the development of activity-based probes for detection of lysine-specific demethylase-1 activity.
Ourailidou, Me; Lenoci, A; Zwergel, Clemens; Rotili, Dante; Mai, Antonello; Dekker, F. J. 4. - 01a Articolo in rivista
paper: BIOORGANIC & MEDICINAL CHEMISTRY (Oxford: Pergamon, 1993-) pp. 847-856 - issn: 0968-0896 - wos: WOS:000394201900004 (9) - scopus: 2-s2.0-85008433321 (10)

11573/1027813 - 2017 - Crystal structures of the mitochondrial deacylase Sirtuin 4 reveal isoform-specific acyl recognition and regulation features.
Pannek, M; Simic, Z; Fuszard, M; Meleshin, M; Rotili, D; Mai, A; Schutkowski, M; Steegborn, C. - 01a Articolo in rivista
paper: NATURE COMMUNICATIONS (London: Nature Publishing Group) pp. - - issn: 2041-1723 - wos: WOS:000415262500001 (64) - scopus: 2-s2.0-85034035870 (63)

11573/1017768 - 2017 - Y3+ embedded in polymeric nanoparticles: Morphology, dimension and stability of composite colloidal system
Venditti, I; Cartoni, A.; Fontana, L.; Testa, G.; Scaramuzzo, F. A.; Faccini, R.; Mancini Terracciano, C.; Solfaroli Camillocci, E.; Morganti, S.; Giordano, A.; Scotognella, T.; Rotili, D.; Dini, V.; Marini, F.; Fratoddi, I - 01a Articolo in rivista
paper: COLLOIDS AND SURFACES. A, PHYSICOCHEMICAL AND ENGINEERING ASPECTS (Elsevier BV:PO Box 211, 1000 AE Amsterdam Netherlands:011 31 20 4853757, 011 31 20 4853642, 011 31 20 4853641, EMAIL: nlinfo-f@elsevier.nl, INTERNET: http://www.elsevier.nl, Fax: 011 31 20 4853598) pp. 125-131 - issn: 0927-7757 - wos: WOS:000412065600018 (20) - scopus: 2-s2.0-85020137711 (20)

11573/1027810 - 2017 - The relevance of Ki calculation for bi-substrate enzymes illustrated by kinetic evaluation of a novel lysine (K) acetyltransferase 8 inhibitor.
Wapenaar, H; Van Den Bosch, T; Leus, Ngj; Van Der Wouden, Pe; Eleftheriadis, N; Hermans, J; Hailu, Gs; Rotili, D; Mai, A; Dömling, A; Bischoff, R; Haisma, Hj; Dekker, F. J. - 01a Articolo in rivista
paper: EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY (Editions Scientifique & Medical Elsevier:23 Rue Linois, F 75724 Paris Cedex 15 France:011 33 1 71724646, INTERNET: http://www.elsevier.fr, Fax: 011 33 1 71724664) pp. 480-486 - issn: 0223-5234 - wos: WOS:000403993500041 (5) - scopus: 2-s2.0-85019413230 (5)

11573/944091 - 2017 - Structural basis of sirtuin 6 activation by synthetic small molecules.
You, W; Rotili, Dante; Li, Tm; Kambach, C; Meleshin, M; Schutkowski, M; Chua, Kf; Mai, Antonello; Steegborn, C. 1. - 01a Articolo in rivista
paper: ANGEWANDTE CHEMIE. INTERNATIONAL EDITION (Wiley-VCH Verlag GmBH:PO Box 101161, D 69451 Weinheim Germany:011 49 6201 606147, EMAIL: service@wiley-vch.de, INTERNET: http://www.wiley-vch.de, Fax: 011 49 6201 606328) pp. 1007-1011 - issn: 1433-7851 - wos: WOS:000394997200011 (104) - scopus: 2-s2.0-85006998900 (108)

11573/884147 - 2016 - Sirtuin functions and modulation: from chemistry to the clinic
Carafa, Vincenzo; Rotili, Dante; Forgione, Mariantonietta; Cuomo, Francesca; Serretiello, Enrica; Hailu, Gebremedhin Solomon; Jarho, Elina; Lahtela Kakkonen, Maija; Mai, Antonello; Altucci, Lucia - 01a Articolo in rivista
paper: CLINICAL EPIGENETICS (Berlin : Springer) pp. 1-21 - issn: 1868-7083 - wos: WOS:000376856700001 (231) - scopus: 2-s2.0-84973864104 (239)

11573/884154 - 2016 - Tumour-specific metabolic adaptation to acidosis is coupled to epigenetic stability in osteosarcoma cells
Chano, Tokuhiro; Avnet, Sofia; Kusuzaki, Katsuyuki; Bonuccelli, Gloria; Sonveaux, Pierre; Rotili, Dante; Mai, Antonello; Baldini, Nicola - 01a Articolo in rivista
paper: AMERICAN JOURNAL OF CANCER RESEARCH (Madison, WI: Published by e-Century Publishing Corporation, Madison) pp. 859-875 - issn: 2156-6976 - wos: WOS:000384444300002 (29) - scopus: 2-s2.0-84991518619 (28)

11573/884170 - 2016 - Histone acetyltransferase inhibitor CPTH6 preferentially targets lung cancer stem-like cells
Di Martile, Marta; Desideri, Marianna; De Luca, Teresa; Gabellini, Chiara; Buglioni, Simonetta; Eramo, Adriana; Sette, Giovanni; Milella, Michele Stanislaw; Rotili, Dante; Mai, Antonello; Carradori, Simone; Secci, Daniela; De Maria, Ruggero; Del Bufalo, Donatella; Trisciuoglio, Daniela - 01a Articolo in rivista
paper: ONCOTARGET (Albany, N.Y. : Impact Journals) pp. 11332-11348 - issn: 1949-2553 - wos: WOS:000375678300047 (36) - scopus: 2-s2.0-84962019515 (37)

11573/871180 - 2016 - c-Jun N-terminal kinase activation by nitrobenzoxadiazoles leads to late-stage autophagy inhibition
Palumbo, Camilla; De Luca, Anastasia; Rosato, Nicola; Forgione, Mariantonietta; Rotili, Dante; Caccuri, Anna Maria - 01a Articolo in rivista
paper: JOURNAL OF TRANSLATIONAL MEDICINE (London: BioMed Central, London) pp. - - issn: 1479-5876 - wos: WOS:000369219900001 (22) - scopus: 2-s2.0-84958170303 (22)

11573/894532 - 2016 - At long last potent and selective KDM5 inhibitors
Rotili, Dante; Mattevi, Andrea - 01a Articolo in rivista
paper: CELL CHEMICAL BIOLOGY (Amsterdam : Elsevier Cambridge, MA : Cell Press) pp. 749-751 - issn: 2451-9456 - wos: WOS:000381509200001 (4) - scopus: 2-s2.0-84984910817 (4)

11573/894534 - 2016 - Polymyxins and quinazolines are LSD1/KDM1A inhibitors with unusual structural features
Speranzini, Valentina; Rotili, Dante; Ciossani, Giuseppe; Pilotto, Simona; Marrocco, Biagina; Forgione, Mariantonietta; Lucidi, Alessia; Forneris, Federico; Mehdipour, Parinaz; Velankar, Sameer; Mai, Antonello; Mattevi, Andrea - 01a Articolo in rivista
paper: SCIENCE ADVANCES (Washington, DC : American Association for the Advancement of Science, 2015-) pp. - - issn: 2375-2548 - wos: WOS:000383734400025 (49) - scopus: 2-s2.0-85020596495 (51)

11573/884171 - 2016 - The histone acetyltransferase p300 inhibitor C646 reduces pro-inflammatory gene expression and inhibits histone deacetylases
Van Den Bosch, Thea; Boichenko, Alexander; Leus, Niek G. J.; Ourailidou, Maria E.; Wapenaar, Hannah; Rotili, Dante; Mai, Antonello; Imhof, Axel; Bischoff, Rainer; Haisma, Hidde J.; Dekker, Frank J. - 01a Articolo in rivista
paper: BIOCHEMICAL PHARMACOLOGY (-Oxford, United Kingdom: Elsevier Science Limited -London ; New York : Pergamon Press, 1958-) pp. 130-140 - issn: 0006-2952 - wos: WOS:000371446300011 (36) - scopus: 2-s2.0-84958753301 (45)

11573/884205 - 2015 - A novel orally active water-soluble inhibitor of human glutathione transferase exerts a potent and selective antitumor activity against human melanoma xenografts
De Luca, Anastasia; Rotili, Dante; Carpanese, Debora; Lenoci, Alessia; Calderan, Laura; Scimeca, Manuel; Mai, Antonello; Bonanno, Elena; Rosato, Antonio; Geroni, Cristina; Quintieri, Luigi; Caccuri, Anna Maria - 01a Articolo in rivista
paper: ONCOTARGET (Albany, N.Y. : Impact Journals) pp. 4126-4143 - issn: 1949-2553 - wos: WOS:000352696200052 (22) - scopus: 2-s2.0-84924251939 (25)

11573/784167 - 2015 - Novel histone deacetylase inhibitors induce growth arrest, apoptosis, and differentiation in sarcoma cancer stem cells
G., Di Pompo; M., Salerno; Rotili, Dante; Valente, Sergio; Zwergel, Clemens; S., Avnet; G., Lattanzi; N., Baldini; Mai, Antonello - 01a Articolo in rivista
paper: JOURNAL OF MEDICINAL CHEMISTRY (Washington, DC: American Chemical Society) pp. 4073-4079 - issn: 0022-2623 - wos: WOS:000354911200031 (52) - scopus: 2-s2.0-84929378676 (49)

11573/884194 - 2015 - A new water soluble MAPK activator exerts antitumor activity in melanoma cells resistant to the BRAF inhibitor vemurafenib
Graziani, Grazia; Artuso, Simona; De Luca, Anastasia; Muzi, Alessia; Rotili, Dante; Scimeca, Manuel; Atzori, Maria Grazia; Ceci, Claudia; Mai, Antonello; Leonetti, Carlo; Levati, Lauretta; Bonanno, Elena; Tentori, Lucio; Caccuri, Anna Maria - 01a Articolo in rivista
paper: BIOCHEMICAL PHARMACOLOGY (-Oxford, United Kingdom: Elsevier Science Limited -London ; New York : Pergamon Press, 1958-) pp. 16-27 - issn: 0006-2952 - wos: WOS:000353858800002 (27) - scopus: 2-s2.0-84930886228 (27)

11573/789900 - 2015 - SIRT5 regulation of ammonia-induced autophagy and mitophagy
Polletta, Lucia; Vernucci, Enza; Carnevale, Ilaria; Arcangeli, Tania; Rotili, Dante; Palmerio, Silvia; Steegborn, Clemens; Nowak, Theresa; Schutkowski, Mike; Pellegrini, Laura; Sansone, Luigi; Villanova, Lidia; Runci, Alessandra; Pucci, Bruna; Morgante, Emanuela; Fini, Massimo; Mai, Antonello; Russo, Matteo A; Tafani, Marco - 01a Articolo in rivista
paper: AUTOPHAGY (Landes Bioscience Georgetown TX 78628) pp. 253-270 - issn: 1554-8627 - wos: WOS:000352778700007 (187) - scopus: 2-s2.0-84943265499 (192)

11573/680651 - 2015 - Synthesis and structure-activity relationship of new cytotoxic agents targeting human glutathione-S-transferases.
Rotili, Dante; De Luca, A; Tarantino, D; Pezzola, S; Forgione, Mariantonietta; Morozzo Della Rocca, B; Falconi, M; Mai, Antonello; Caccuri, A. M. - 01a Articolo in rivista
paper: EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY (Editions Scientifique & Medical Elsevier:23 Rue Linois, F 75724 Paris Cedex 15 France:011 33 1 71724646, INTERNET: http://www.elsevier.fr, Fax: 011 33 1 71724664) pp. 156-171 - issn: 0223-5234 - wos: WOS:000348003500017 (30) - scopus: 2-s2.0-84908450815 (32)

11573/779609 - 2015 - Pyrrole- and indole-containing tranylcypromine derivatives as novel lysine-specific demethylase 1 inhibitors active on cancer cells.
Veronica, Rodriguez; Valente, Sergio; Stefano, Rovida; Rotili, Dante; Stazi, Giulia; Lucidi, Alessia; Giuseppe, Ciossani; Andrea, Mattevi; Oronza A., Botrugno; Paola, Dessanti; Ciro, Mercurio; Paola, Vianello; Saverio, Minucci; Mario, Varasi; Mai, Antonello - 01a Articolo in rivista
paper: MEDCHEMCOMM (Cambridge : Royal Society of Chemistry, 2010-) pp. 665-670 - issn: 2040-2503 - wos: WOS:000352903400023 (22) - scopus: 2-s2.0-84928004801 (23)

11573/884188 - 2015 - Targeting lysine deacetylases (KDACs) in parasites
Wang, Qi; Rosa, Bruce A.; Nare, Bakela; Powell, Kerrie; Valente, Sergio; Rotili, Dante; Mai, Antonello; Marshall, Garland R.; Mitreva, Makedonka - 01a Articolo in rivista
paper: PLOS NEGLECTED TROPICAL DISEASES (San Francisco, CA : Public Library of Science) pp. e000426- - issn: 1935-2727 - wos: WOS:000363031200020 (38) - scopus: 2-s2.0-84943193825 (41)

11573/884182 - 2015 - Enzyme kinetics and inhibition of histone acetyltransferase KAT8
Wapenaar, Hannah; Van Der Wouden, Petra E; Groves, Matthew R; Rotili, Dante; Mai, Antonello; Dekker, Frank J. - 01a Articolo in rivista
paper: EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY ([Paris] : Elsevier, [198?]-) pp. 289-296 - issn: 1768-3254 - wos: WOS:000364891400020 (25) - scopus: 2-s2.0-84945264596 (27)

11573/1155213 - 2014 - Sirtuins blunt reactive gliosis in an in vitro model of Alzheimer’s disease.
Bronzuoli, Maria Rosanna; Scuderi, Caterina; Stecca, Claudia; Rotili, Dante; Valente, Sergio; Cugno, Michele; Mai, Antonello; Steardo, Luca. - 04d Abstract in atti di convegno
conference: 17° Simposio SIF Dottorandi, Assegnisti di Ricerca Postdottorandi e Specializzandi in Farmacologia e Scienze Affini (Rimini)
book: 17° Simposio SIF Dottorandi, Assegnisti di Ricerca Postdottorandi e Specializzandi in Farmacologia e Scienze Affini. - ()

11573/685071 - 2014 - Evaluation of a large library of (thiazol-2-yl)hydrazones and analogues as histone acetyltransferase inhibitors: Enzyme and cellular studies.
Carradori, S; Rotili, Dante; De Monte, Celeste; Lenoci, A; D'ascenzio, M; Rodriguez, V; Filetici, Patrizia; Miceli, M; Nebbioso, A; Altucci, L; Secci, Daniela; Mai, Antonello - 01a Articolo in rivista
paper: EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY (Editions Scientifique & Medical Elsevier:23 Rue Linois, F 75724 Paris Cedex 15 France:011 33 1 71724646, INTERNET: http://www.elsevier.fr, Fax: 011 33 1 71724664) pp. 569-578 - issn: 0223-5234 - wos: WOS:000337985400049 (46) - scopus: 2-s2.0-84900559630 (51)

11573/556419 - 2014 - Context-Selective Death of Acute Myeloid Leukemia Cells Triggered by the Novel Hybrid Retinoid-HDAC Inhibitor MC2392.
De Bellis, F; Carafa, V; Conte, M; Rotili, Dante; Petraglia, F; Matarese, F; Françoijs, Kj; Ablain, J; Valente, Sergio; Castellano, R; Goubard, A; Collette, Y; Mandoli, A; Martens, Jh; De Thé, H; Nebbioso, A; Mai, Antonello; Stunnenberg, Hg; Altucci, L. - 01a Articolo in rivista
paper: CANCER RESEARCH (American Association of Cancer Research:150 South Independence Mall West, #826:Philadelphia, PA 19106:(215)440-9300, EMAIL: pubs@aacr.org, INTERNET: http://www.aacr.org, Fax: (215)440-7228) pp. 2328-2339 - issn: 0008-5472 - wos: WOS:000334584200020 (28) - scopus: 2-s2.0-84899541163 (33)

11573/556417 - 2014 - Quinoline-based p300 histone acetyltransferase inhibitors with pro-apoptotic activity in human leukemia U937 cells.
Lenoci, Alessia; Tomassi, S; Conte, M; Benedetti, R; Rodriguez, V; Carradori, Simone; Secci, Daniela; Castellano, S; Sbardella, G; Filetici, P; Novellino, E; Altucci, L; Rotili, Dante; Mai, Antonello - 01a Articolo in rivista
paper: CHEMMEDCHEM (Weinheim : Wiley-VCH-Verl..) pp. 542-548 - issn: 1860-7187 - wos: WOS:000331795500010 (23) - scopus: 2-s2.0-84896698147 (24)

11573/542432 - 2014 - Pan-histone demethylase inhibitors simultaneously targeting Jumonji C and lysine-specific demethylases display high anticancer activities
Rotili, Dante; Stefano, Tomassi; Mariarosaria, Conte; Rosaria, Benedetti; Marcello, Tortorici; Giuseppe, Ciossani; Valente, Sergio; Marrocco, Biagina; Labella, Donatella; Ettore, Novellino; Andrea, Mattevi; Lucia, Altucci; Tumber, Anthony; Yapp, Clarence; N. F., King Oliver; Richard J., Hopkinson; Akane, Kawamura; J., Schofield Christopher; Mai, Antonello - 01a Articolo in rivista
paper: JOURNAL OF MEDICINAL CHEMISTRY (Washington, DC: American Chemical Society) pp. 42-55 - issn: 0022-2623 - wos: WOS:000329677800004 (90) - scopus: 2-s2.0-84892565144 (100)

11573/681257 - 2014 - Properly substituted analogues of BIX-01294 lose inhibition of G9a histone methyltransferase and gain selective anti-DNA methyltransferase 3A activity.
Rotili, Dante; Tarantino, D; Marrocco, Biagina; Gros, C; Masson, V; Poughon, V; Ausseil, F; Chang, Y; Labella, D; Cosconati, S; Di Maro, S; Novellino, E; Schnekenburger, M; Grandjenette, C; Bouvy, C; Diederich, M; Cheng, X; Arimondo, Pb; Mai, Antonello - 01a Articolo in rivista
paper: PLOS ONE (San Francisco, CA : Public Library of Science) pp. - - issn: 1932-6203 - wos: WOS:000338213300096 (31) - scopus: 2-s2.0-84901487126 (34)

11573/681252 - 2014 - Exploring the role of 2-chloro-6-fluoro substitution in 2-alkylthio-6-benzyl-5-alkylpyrimidin-4(3H)-ones: effects in HIV-1-infected cells and in HIV-1 reverse transcriptase enzymes
Rotili, Dante; Tarantino, D; Nawrozkij, Mb; Babushkin, As; Botta, G; Marrocco, Biagina; Cirilli, R; Menta, Sergio; Badia, R; Crespan, E; Ballante, Flavio; Ragno, Rino; Esté, Ja; Maga, G; Mai, Antonello - 01a Articolo in rivista
paper: JOURNAL OF MEDICINAL CHEMISTRY (Washington, DC: American Chemical Society) pp. 5212-5225 - issn: 0022-2623 - wos: WOS:000338184100018 (18) - scopus: 2-s2.0-84903515653 (18)

11573/643824 - 2014 - Sirtuin modulators control reactive gliosis in an in vitro model of alzheimer's disease
Scuderi, Caterina; Stecca, Claudia; Bronzuoli, Maria Rosanna; Rotili, Dante; Valente, Sergio; Mai, Antonello; Steardo, Luca - 01a Articolo in rivista
paper: FRONTIERS IN PHARMACOLOGY (Lausanne: Frontiers Media S.A., 2010-) pp. - - issn: 1663-9812 - wos: WOS:000347086800001 (48) - scopus: 2-s2.0-84904631078 (53)

11573/553541 - 2014 - I kappa B kinase (IKK)-epsilon targets interferon regulatory factor 1 in activated T lymphocytes.
Sgarbanti, M; Marsili, G; Remoli, Al; Stellacci, E; Mai, Antonello; Rotili, Dante; Perrotti, E; Acchioni, C; Orsatti, R; Iraci, N; Ferrari, M; Borsetti, A; Hiscott, J; Battistini, A. - 01a Articolo in rivista
paper: MOLECULAR AND CELLULAR BIOLOGY (American Society for Microbiology / DC:1752 N Street Northwest:Washington, DC 20036:(202)737-3600, EMAIL: jadelman@asmusa.org, INTERNET: http://www.asmusa.org/asm.htm, Fax: (202)942-9342) pp. 1054-1065 - issn: 0270-7306 - wos: WOS:000331995800012 (27) - scopus: 2-s2.0-84894284462 (29)

11573/513467 - 2013 - Inhibition of Class I Histone Deacetylases Unveils a Mitochondrial Signature and Enhances Oxidative Metabolism in Skeletal Muscle and Adipose Tissue.
Galmozzi, A.; Mitro, N.; Ferrari, A.; Gers, E.; Gilardi, F.; Godio, C.; Cermenati, G.; Gualerzi, A.; Donetti, E.; Rotili, Dante; Valente, Sergio; Guerrini, U.; Caruso, D.; Mai, Antonello; Saez, E.; De Fabiani, E.; Crestani, M. - 01a Articolo in rivista
paper: DIABETES (American Diabetes Association:National Service Center, 1701 North Beaureguard Street:Alexandria, VA 22311:(800)232-3472, (703)549-1500, INTERNET: http://www.diabetes.org/diabetscare, Fax: (703)549-6995) pp. 732-742 - issn: 0012-1797 - wos: WOS:000315556400017 (176) - scopus: 2-s2.0-84869106554 (189)

11573/525206 - 2013 - PARP-1 Modulates Amyloid Beta Peptide-Induced Neuronal Damage
Martire, Sara; Fuso, Andrea; Rotili, Dante; Tempera, Italo; Giordano, Cesare Giovanni; Ivana De, Zottis; Alessia, Muzi; Patrizia, Vernole; Grazia, Graziani; Emanuela, Lococo; Faraldi, Martina; Maras, Bruno; Scarpa, Sigfrido; Mosca, Luciana; D'erme, Maria - 01a Articolo in rivista
paper: PLOS ONE (San Francisco, CA : Public Library of Science) pp. e72169- - issn: 1932-6203 - wos: WOS:000325025200005 (54) - scopus: 2-s2.0-84884573236 (63)

11573/525223 - 2013 - ROLE OF POLY(ADP-RIBOSE)POLYMERASE IN AMYLOID BETA TOXICITY AND ALZHEIMER DISEASE
Mosca, Luciana; Fuso, Andrea; Martire, Sara; Rotili, Dante; Giordano, Cesare Giovanni; Emanuela, Lococo; Faraldi, Martina; P., Vernole; G., Graziani; Francioso, Antonio; Maras, Bruno; M., D'erme - 04a Atto di comunicazione a congresso
conference: AD/PD 2013 (Firenze)
book: Abstract book - ()

11573/442878 - 2012 - An Analog of BIX-01294 Selectively Inhibits a Family of Histone H3 Lysine 9 Jumonji Demethylases
Anup K., Upadhyay; Rotili, Dante; Ji Woong, Han; Ruogu, Hu; Yanqi, Chang; Donatella, Labella; Xing, Zhang; Young Sup, Yoon; Mai, Antonello; Xiaodong, Cheng - 01a Articolo in rivista
paper: JOURNAL OF MOLECULAR BIOLOGY (-LONDON, ENGLAND: ACADEMIC PRESS LTD ELSEVIER SCIENCE LTD, -London; New York: Academic Press.) pp. 319-327 - issn: 0022-2836 - wos: WOS:000301313600001 (43) - scopus: 2-s2.0-84862777760 (46)

11573/511464 - 2012 - PARP-1 inhibition decreases Beta-Amyloid-induced neurodegeneration: a cellular and animal model study
Martire, Sara; Fuso, Andrea; Rotili, Dante; A., Muzi; Giordano, Cesare Giovanni; P., Vernole; E., Lococo; Faraldi, Martina; Masci, Alessandra; Miele, Adriana Erica; G., Graziani; Scarpa, Sigfrido; Mosca, Luciana; D'erme, Maria - 04c Atto di convegno in rivista
paper: FREE RADICAL BIOLOGY & MEDICINE (Elsevier Science Limited:Oxford Fulfillment Center, PO Box 800, Kidlington Oxford OX5 1DX United Kingdom:011 44 1865 843000, 011 44 1865 843699, EMAIL: asianfo@elsevier.com, tcb@elsevier.co.UK, INTERNET: http://www.elsevier.com, http://www.elsevier.com/locate/shpsa/, Fax: 011 44 1865 843010) pp. S182- - issn: 0891-5849 - wos: WOS:000209480800378 (0) - scopus: (0)
conference: 16th SFRRI Biennial Meeting (London)

11573/895421 - 2012 - 6-(Arylmethyl)pyrimidin-4(3H)-ones: Anthology and prospects of highly efficient anti-HIV agents
Novakov, I. A.; Artico, M.; Mai, Antonello; Rotili, Dante; Orlinson, B. S.; Brunilina, L. L.; Nawrozkij, M. B. - 01a Articolo in rivista
paper: RUSSIAN CHEMICAL BULLETIN (- New York : SPRINGER -New York : Consultants Bureau, c1993-) pp. 1399-1418 - issn: 1066-5285 - wos: WOS:000321771700009 (11) - scopus: 2-s2.0-84887395127 (11)

11573/495328 - 2012 - Carprofen Analogues as Sirtuin Inhibitors: Enzyme and Cellular Studies
Paolo, Mellini; Vincenzo, Carafa; Barbara Di, Rienzo; Rotili, Dante; De Vita, Daniela; Roberto, Cirilli; Bruno, Gallinella; Donatella Paola, Provvisiero; Salvatore Di, Maro; Ettore, Novellino; Lucia, Altucci; Mai, Antonello - 01a Articolo in rivista
paper: CHEMMEDCHEM (Weinheim : Wiley-VCH-Verl..) pp. 1905-1908 - issn: 1860-7187 - wos: WOS:000310485200005 (14) - scopus: 2-s2.0-84868149996 (15)

11573/455654 - 2012 - 2-(Alkyl/aryl)amino-6-benzylpyrimidin-4(3H)-ones as inhibitors of wild-type and mutant HIV-1: enantioselectivity studies.
Rotili, Dante; A., Samuele; Domenico, Tarantino; Ragno, Rino; Musmuca, Ira; Ballante, Flavio; G., Botta; Morera, Ludovica; Pierini, Marco; R., Cirilli; M. B., Nawrozkij; E., Gonzalez; B., Clotet; Marino, Artico; J. A., Este; G., Maga; Mai, Antonello - 01a Articolo in rivista
paper: JOURNAL OF MEDICINAL CHEMISTRY (Washington DC : ACS Publications) pp. 3558-3562 - issn: 1520-4804 - wos: WOS:000302591100058 (29) - scopus: 2-s2.0-84859804994 (30)

11573/485200 - 2012 - Benzodeazaoxaflavins as sirtuin inhibitors with antiproliferative properties in cancer stem cells.
Rotili, Dante; Tarantino, D; Carafa, V; Paolini, C; Schemies, J; Jung, M; Botta, G; Di Maro, S; Novellino, E; Steinkühler, C; De Maria, R; Gallinari, P; Altucci, L; Mai, Antonello - 01a Articolo in rivista
paper: JOURNAL OF MEDICINAL CHEMISTRY (Washington, DC: American Chemical Society) pp. 8193-8197 - issn: 0022-2623 - wos: WOS:000309153500023 (27) - scopus: 2-s2.0-84866849116 (30)

11573/759461 - 2012 - Discovery of salermide-related sirtuin inhibitors: binding mode studies and antiproliferative effects in cancer cells including cancer stem cells.
Rotili, Dante; Tarantino, D; Nebbioso, A; Paolini, C; Huidobro, C; Lara, E; Mellini, P; Lenoci, Alessia; Pezzi, R; Botta, G; Lahtela Kakkonen, M; Poso, A; Steinkühler, C; Gallinari, P; De Maria, R; Fraga, M; Esteller, M; Altucci, L; Mai, Antonello - 01a Articolo in rivista
paper: JOURNAL OF MEDICINAL CHEMISTRY (Washington, DC: American Chemical Society) pp. 10937-10947 - issn: 0022-2623 - wos: WOS:000312681100009 (72) - scopus: 2-s2.0-84871662210 (75)

11573/485203 - 2012 - p300/CBP-associated factor selectively regulates the extinction of conditioned fear.
W., Wei; C. M., Coelho; X., Li; R., Marek; S., Yan; S., Anderson; D., Meyers; C., Mukherjee; G., Sbardella; S., Castellano; C., Milite; Rotili, Dante; Mai, Antonello; P. A., Cole; P., Sah; M. S., Kobor; T. W., Bredy - 01a Articolo in rivista
paper: THE JOURNAL OF NEUROSCIENCE (Society for Neuroscience:11 Dupont Circle, Suite 500:Washington, DC 20036:(202)462-6688, EMAIL: membership@sfn.org, subs@sfn.org, INTERNET: http://www.sfn.org, Fax: (202)462-1547) pp. 11930-11941 - issn: 0270-6474 - wos: WOS:000308213900003 (67) - scopus: 2-s2.0-84865472870 (73)

11573/442881 - 2011 - Modulation of cell differentiation, proliferation, and tumor growth by dihydrobenzyloxopyrimidine non-nucleoside reverse transcriptase inhibitors
Gianluca, Sbardella; Mai, Antonello; Sara, Bartolini; Sabrina, Castellano; Roberto, Cirilli; Rotili, Dante; Ciro, Milite; Marisabella, Santoriello; Serena, Orlando; Ilaria, Sciamanna; Annalucia, Serafino; Patrizia, Lavia; Corrado, Spadafora - 01a Articolo in rivista
paper: JOURNAL OF MEDICINAL CHEMISTRY (Washington, DC: American Chemical Society) pp. 5927-5936 - issn: 0022-2623 - wos: WOS:000294077300023 (11) - scopus: 2-s2.0-80051873043 (13)

11573/442885 - 2011 - Histone deacetylase inhibition modulates deoxyribonucleotide pools and enhances the antitumor effects of the ribonucleotide reductase inhibitor 3'-C-methyladenosine in leukaemia cells.
Meli, M; Tolomeo, M; Grifantini, M; Mai, Antonello; Cappellacci, L; Petrelli, R; Rotili, Dante; Ferro, A; Saiko, P; Szekeres, T; Dusonchet, L. - 01a Articolo in rivista
paper: INTERNATIONAL JOURNAL OF ONCOLOGY (National Hellenic Research Foundation:48 Vas Constatinou Avenue, Athens 11635 Greece:011 30 1 7241505, Fax: 011 30 1 7241505Editore attuale:PROFESSOR D A SPANDIDOS, 1, S MERKOURI ST, EDITORIAL OFFICE,, ATHENS, GREECE, 116 35. Editore precedente:Editorial Academy of the International Journal of Oncology.) pp. - - issn: 1019-6439 - wos: WOS:000289815800026 (7) - scopus: 2-s2.0-79954993415 (7)

11573/511590 - 2011 - Apoptotic events are modulated by poly(ADP-ribose)polymerase in cellular and animal models of Alzheimer disease
Mosca, Luciana; Fuso, Andrea; Aureli, Cristina; Martire, Sara; Masci, Alessandra; Rotili, Dante; De Leo, Alessandra; Giordano, Cesare Giovanni; Scarpa, Sigfrido; D'erme, Maria - 04a Atto di comunicazione a congresso
book: Abstract book - ()

11573/511592 - 2011 - PARP activation modulates apoptosis events in cellular and animal models of Alzheimer disease
Mosca, Luciana; Martire, Sara; Fuso, Andrea; D., Beyaie; Masci, Alessandra; Rotili, Dante; De Leo, Alessandra; Consalvi, Valerio; Giordano, Cesare Giovanni; Scarpa, Sigfrido; D'erme, Maria - 04a Atto di comunicazione a congresso
conference: Molecular Mechanisms of Neurodegeneration (Milan, Italy,)
book: Abstract book - ()

11573/379664 - 2011 - Biological Effects of MC2050, a Quinazoline-Based PARP-1 Inhibitor, in Human Neuroblastoma and EBV-Positive Burkitt's Lymphoma Cells
Mosca, Luciana; Rotili, Dante; Tempera, Italo; Masci, Alessandra; Fontana, Mario; Chiaraluce, Roberta; Mastromarino, Paola; D'erme, Maria; Mai, Antonello - 01a Articolo in rivista
paper: CHEMMEDCHEM (Weinheim : Wiley-VCH-Verl..) pp. 606-611 - issn: 1860-7179 - wos: WOS:000288814900006 (12) - scopus: 2-s2.0-79953056639 (11)

11573/442676 - 2011 - Photoactivable peptides for identifying enzyme-substrate and protein-protein interactions.
Rotili, Dante; Altun, M; Hamed, Rb; Loenarz, C; Thalhammer, A; Hopkinson, Rj; Tian, Ym; Ratcliffe, Pj; Mai, Antonello; Kessler, Bm; Schofield, C. J. - 01a Articolo in rivista
paper: CHEMICAL COMMUNICATIONS (Royal Society of Chemistry:Thomas Graham House, Science Park, Cambridge CB4 0WF United Kingdom:011 44 1223 432360, EMAIL: sales@rsc.org, INTERNET: http://www.rsc.org, http://www.chensoc.org, Fax: 011 44 1223 423429) pp. 1488-1490 - issn: 1359-7345 - wos: WOS:000286389500026 (5) - scopus: 2-s2.0-78751521073 (5)

11573/442886 - 2011 - Targeting histone demethylases: A new avenue for the fight against cancer
Rotili, Dante; Mai, Antonello - 01a Articolo in rivista
paper: GENES & CANCER (Thousand Oaks, CA: SAGE Publications) pp. 663-679 - issn: 1947-6019 - wos: (0) - scopus: 2-s2.0-80054787805 (168)

11573/442882 - 2011 - A Photoreactive Small-Molecule Probe for 2-Oxoglutarate Oxygenases
Rotili, Dante; Mikael, Altun; Akane, Kawamura; Alexander, Wolf; Roman, Fischer; I. K., Leung; Mukram M, Mackeen; Ya Min, Tian; Peter J, Ratcliffe; Mai, Antonello; Benedikt M, Kessler; Christopher J, Schofield - 01a Articolo in rivista
paper: CHEMISTRY & BIOLOGY (Current Science:400 Market Street, Suite 700:Philadelphia, PA 19106:(800)427-1796, (215)574-2266, EMAIL: info@phl.cursci.com, INTERNET: http://www-current-science-group.com, Fax: (215)574-2225) pp. 642-654 - issn: 1074-5521 - wos: WOS:000291499600013 (42) - scopus: 2-s2.0-79957487715 (44)

11573/379781 - 2011 - Diarylpyrimidine-Dihydrobenzyloxopyrimidine Hybrids: New, Wide-Spectrum Anti-HIV-1 Agents Active at (Sub)-Nanomolar Level.
Rotili, Dante; Tarantino, D; Artico, M; Nawrozkij, Mb; Gonzalez Ortega, E; Clotet, B; Samuele, A; Este, Ja; Maga, G; Mai, Antonello - 01a Articolo in rivista
paper: JOURNAL OF MEDICINAL CHEMISTRY (Washington, DC: American Chemical Society) pp. 3091-3096 - issn: 0022-2623 - wos: WOS:000289697800043 (47) - scopus: 2-s2.0-79955455754 (51)

11573/442679 - 2011 - Simplification of the tetracyclic SIRT1-selective inhibitor MC2141: Coumarin- and pyrimidine-based SIRT1/2 inhibitors with different selectivity profile
Rotili, Dante; Vincenzo, Carafa; Domenico, Tarantino; Giorgia, Botta; Angela, Nebbioso; Lucia, Altucci; Mai, Antonello - 01a Articolo in rivista
paper: BIOORGANIC & MEDICINAL CHEMISTRY (Oxford: Pergamon, 1993-) pp. 3659-3668 - issn: 0968-0896 - wos: WOS:000291477600007 (25) - scopus: 2-s2.0-79958261783 (27)

11573/434969 - 2010 - HDACs class II-selective inhibition alters nuclear receptor-dependent differentiation
A., Nebbioso; C., Dell'aversana; A., Bugge; R., Sarno; Valente, Sergio; Rotili, Dante; F., Manzo; D., Teti; S., Mandrup; P., Ciana; A., Maggi; Mai, Antonello; H., Gronemeyer; L., Altucci - 01a Articolo in rivista
paper: JOURNAL OF MOLECULAR ENDOCRINOLOGY (Pubblicata da: SOC ENDOCRINOLOGY, 22 APEX COURT, WOODLANDS, BRADLEY STOKE, BRISTOL, ENGLAND, BS32 4JT primo editore: Journal of Endocrinology Limited:17 18 Courtyard Woodlands, Bristol BS12 4NQ United Kingdom:011 44 117 9616046, EMAIL: sxa15@psu.edu, INTERNET: http://www.psu.edu, Fax: 011 44 117 9616071) pp. 219-228 - issn: 0952-5041 - wos: WOS:000282528800005 (51) - scopus: 2-s2.0-77957824326 (55)

11573/13728 - 2010 - Proteomic profile of differentially expressed plasma proteins from dystrophic mice and following suberoylanilide hydroxamic acid treatment
Colussi, C.; Banfi, C.; Brioschi, M.; Tremoli, E.; Straino, S.; Spallotta, F.; Mai, Antonello; Rotili, Dante; Capogrossi Mc, Gaetano C. - 01a Articolo in rivista
paper: PROTEOMICS. CLINICAL APPLICATIONS (Weinheim : Wiley-VCH-Verl.) pp. 71-83 - issn: 1862-8346 - wos: WOS:000274264900007 (28) - scopus: 2-s2.0-77951727320 (29)

11573/13666 - 2010 - The histone deacetylase inhibitor suberoylanilide hydroxamic acid reduces cardiac arrhythmias in dystrophic mice
Colussi, C.; Berni, R.; Rosati, J.; Straino, S.; Vitale, S.; Spallotta, F.; Baruffi, S.; Bocchi, L.; Delucchi, F.; Rossi, S.; Savi, M.; Rotili, Dante; Quaini, F.; Macchi, E.; Stilli, D.; Musso, E.; Mai, Antonello; Capogrossi Mc, Gaetano C. - 01a Articolo in rivista
paper: CARDIOVASCULAR RESEARCH (editore attuale: ELSEVIER SCIENCE BV, PO BOX 211, AMSTERDAM, NETHERLANDS, 1000 AE primo editore: BMJ / British Medical Journal Publishing Group:PO Box 299, London WC1H 9TD United Kingdom:011 44 20 73836270, EMAIL: subscriptions@bmjgroup.com, INTERNET: http://www.bmjpg.com/bmj, Fax: 011 44 20 73836402) pp. 73-82 - issn: 0008-6363 - wos: WOS:000278690000012 (40) - scopus: 2-s2.0-77955165005 (42)

11573/442677 - 2010 - Characterization of Sirtuin Inhibitors in Nematodes Expressing a Muscular Dystrophy Protein Reveals Muscle Cell and Behavioral Protection by Specific Sirtinol Analogues
Matthieu Y., Pasco; Rotili, Dante; Lucia, Altucci; Francesca, Farina; Guy A., Rouleau; Mai, Antonello; Christian, Neri - 01a Articolo in rivista
paper: JOURNAL OF MEDICINAL CHEMISTRY (Washington, DC: American Chemical Society) pp. 1407-1411 - issn: 0022-2623 - wos: WOS:000274270900047 (35) - scopus: 2-s2.0-77249153712 (36)

11573/456124 - 2010 - The specific character of the reaction of derivatives of 2-thioxo-2,3-dihydropyrimidin-4(1H)-one with iodomethane and alkyl chloromethyl sulfides.
Novakov, Ia; Orlinson, B; Nawrozkij, Mb; Mai, Antonello; Artico, Marino; Rotili, Dante; Eremiychuk, As; Gordeeva, Ea; Brunilina, Ll; Este, J. A. - 01a Articolo in rivista
paper: CHEMISTRY OF HETEROCYCLIC COMPOUNDS (Consultants Bureau:A Division of Plenum Publishing Corporation, 233 Spring Street, Sixth Floor:New York, NY 10013:(800)221-9369, (212)620-8082, Fax: (212)463-0742) pp. - - issn: 0009-3122 - wos: WOS:000279454900010 (1) - scopus: 2-s2.0-77954638922 (0)

11573/895420 - 2010 - Evaluation of histone deacetylases as drug targets in Huntington's disease models
Quinti, Luisa; Chopra, Vanita; Rotili, Dante; Valente, Sergio; Amore, Allison; Franci, Gianluigi; Meade, Sarah; Valenza, Marta; Altucci, Lucia; Maxwell, Michele M.; Cattaneo, Elena; Hersch, Steven; Mai, Antonello; Kazantsev, Aleksey - 02a Capitolo o Articolo
book: PLOS CURRENTS - ()

11573/456116 - 2010 - Identification of Tri- and Tetracyclic Pyrimidinediones as Sirtuin Inhibitors
Rotili, Dante; Tarantino, Domenico; Vincenzo, Carafa; Ester, Lara; Sarah, Meade; Giorgia, Botta; Angela, Nebbioso; Jorg, Schemies; Manfred, Jung; Aleksey G, Kazantsev; Manel, Esteller; Mario F, Fraga; Lucia, Altucci; Mai, Antonello - 01a Articolo in rivista
paper: CHEMMEDCHEM (Weinheim : Wiley-VCH-Verl..) pp. 674-677 - issn: 1860-7179 - wos: WOS:000277725100005 (45) - scopus: 2-s2.0-77951697156 (44)

11573/229552 - 2010 - Nitric oxide determines mesodermic differentiation of mouse embryonic stem cells by activating class IIa histone deacetylases: potential therapeutic implications in a mouse model of hindlimb ischemia
Spallotta, F; Rosati, J; Straino, S; Nanni, S; Grasselli, A; Ambrosino, V; Rotili, Dante; Valente, Sergio; Farsetti, A; Mai, Antonello; Capogrossi, Mc; Gaetano, C; Illi, B. - 01a Articolo in rivista
paper: STEM CELLS (Alphamed Press Incorporated:1 Prestige Place, Suite 290:Miamisburg, OH 45342:(937)291-2355, EMAIL: alphamedpress@alphamedpress.com, INTERNET: http://www.alphamedpress.com, Fax: (937)291-4229) pp. 431-442 - issn: 1066-5099 - wos: WOS:000277093700006 (48) - scopus: 2-s2.0-77950581254 (47)

11573/229551 - 2009 - Shock and kill" effects of class I-selective histone deacetylase inhibitors in combination with the glutathione synthesis inhibitor buthionine sulfoximine in cell line models for HIV-1 quiescence
Andrea, Savarino; Mai, Antonello; Sandro, Norelli; Sary El, Daker; Valente, Sergio; Rotili, Dante; Lucia, Altucci; Palamara, Anna Teresa; Enrico, Garaci - 01a Articolo in rivista
paper: RETROVIROLOGY (London : BioMed Central) pp. 52-52 - issn: 1742-4690 - wos: WOS:000267430700001 (96) - scopus: 2-s2.0-67649259174 (95)

11573/13145 - 2009 - Chiral HPLC separation and absolute configuration of novel S-DABO derivatives.
Cirilli, R; Ferretti, R; La Torre, F; Borioni, A; Fares, V; Camalli, M; Faggi, C; Rotili, Dante; Mai, Antonello - 01a Articolo in rivista
paper: CHIRALITY (John Wiley & Sons Incorporated:Customer Service, 111 River Street:Hoboken, NJ 07030:(800)225-5945, (201)748-6000, EMAIL: societyinfo@wiley.com, INTERNET: http://www.wiley.com, Fax: (212)748-6551) pp. 604-612 - issn: 0899-0042 - wos: WOS:000267250300007 (10) - scopus: 2-s2.0-67649403720 (11)

11573/456128 - 2009 - Reactions of 6-benzyl-5-methyl-2-(methylsulfanyl)pyrimidin-4(3H)-one with aliphatic and aliphatic-aromatic amines
I. A., Novakov; B. S., Orlinson; Mai, Antonello; Artico, Marino; Rotili, Dante; M. B., Navrotskii; E. A., Gordeeva; E. N., Savel'ev - 01a Articolo in rivista
paper: RUSSIAN JOURNAL OF ORGANIC CHEMISTRY (pubblicata da: MAIK NAUKA/INTERPERIODICA, C/O KLUWER ACADEMIC-PLENUM PUBLISHERS, 233 SPRING ST, NEW YORK, USA, NY, 10013-1578) pp. 773-776 - issn: 1070-4280 - wos: WOS:000266829300021 (5) - scopus: 2-s2.0-67049164618 (3)

11573/360909 - 2009 - Salermide, a Sirtuin inhibitor with a strong cancer-specific proapoptotic effect.
Lara, E; Mai, Antonello; Calvanese, V; Altucci, L; Lopez Nieva, P; Martinez Chantar, Ml; Varela Rey, M; Rotili, Dante; Nebbioso, A; Ropero, S; Montoya, G; Oyarzabal, J; Velasco, S; Serrano, M; Witt, M; Villar Garea, A; Inhof, A; Mato, Jm; Esteller, M; Fraga, Mf - 01a Articolo in rivista
paper: ONCOGENE (Macmillan Magazines Limited:Porters South Crinian Street, London N1 9XW United Kingdom:011 44 207 8334000, 011 44 171 8434982, Fax: 011 44 207 812358) pp. 781-791 - issn: 0950-9232 - wos: WOS:000263320000001 (209) - scopus: 2-s2.0-60149091562 (225)

11573/456126 - 2009 - Stereoselective synthesis of 2-substituted 6-[1-(2,6-difluorophenyl)ethyl]-5-methylpyrimidin-4(3H)-ones.
Mai, Antonello; Artico, Marino; Rotili, Dante; Novakov, Ia; Orlinson, Bs; Navrotskii, Mb; Eremiichuk, As; Gordeeva, E. A. - 01a Articolo in rivista
paper: RUSSIAN JOURNAL OF ORGANIC CHEMISTRY (pubblicata da: MAIK NAUKA/INTERPERIODICA, C/O KLUWER ACADEMIC-PLENUM PUBLISHERS, 233 SPRING ST, NEW YORK, USA, NY, 10013-1578) pp. 1531-1534 - issn: 1070-4280 - wos: WOS:000271810500019 (1) - scopus: 2-s2.0-70450201365 (0)

11573/361722 - 2009 - Identification of 4-hydroxyquinolines inhibitors of p300/CBP histone acetyltransferases
Mai, Antonello; Rotili, Dante; Tarantino, Domenico; Angela, Nebbioso; Sabrina, Castellano; Gianluca, Sbardella; Marc, Tini; Lucia, Altucci - 01a Articolo in rivista
paper: BIOORGANIC & MEDICINAL CHEMISTRY LETTERS (Oxford: Pergamon, Amsterdam the Netherlands: Elsevier) pp. 1132-1135 - issn: 0960-894X - wos: WOS:000263295200021 (62) - scopus: 2-s2.0-59749103028 (66)

11573/442678 - 2009 - Histone deacetylase inhibitors and neurodegenerative disorders: Holding the promise
Mai, Antonello; Rotili, Dante; Valente, Sergio; Aleksey, Kazantsev - 01a Articolo in rivista
paper: CURRENT PHARMACEUTICAL DESIGN (Bentham Science Publishers BV:PO Box 7917, Exec Ste Y 26, Saif Zone Sharjah Uae:011 971 6 5571132, EMAIL: benthams@emirates.net.ae, INTERNET: http://www.bentham.org, Fax: 011 971 6 5571134) pp. 3940-3957 - issn: 1381-6128 - wos: WOS:000271385600003 (69) - scopus: 2-s2.0-70649108817 (69)

11573/434973 - 2009 - Selective class II HDAC inhibitors impair myogenesis by modulating the stability and activity of HDAC-MEF2 complexes.
Nebbioso, A; Manzo, F; Miceli, M; Conte, M; Manente, L; Baldi, A; De Luca, A; Rotili, Dante; Valente, Sergio; Mai, Antonello; Usiello, A; Gronemeyer, H; Altucci, L. - 01a Articolo in rivista
paper: EMBO REPORTS (Oxford : Oxford University Press, 2000-) pp. 776-782 - issn: 1469-221X - wos: WOS:000267599700022 (116) - scopus: 2-s2.0-67650083046 (118)

11573/227010 - 2009 - Non-cancer uses of histone deacetylase inhibitors: effects on infectious diseases and β-hemoglobinopathies
Rotili, Dante; Simonetti, Giovanna; A., Savarino; Palamara, Anna Teresa; Migliaccio, A. R.; Mai, Antonello - 01a Articolo in rivista
paper: CURRENT TOPICS IN MEDICINAL CHEMISTRY (Hilversum : Bentham Science Publishers) pp. 272-291 - issn: 1568-0266 - wos: WOS:000265798300006 (37) - scopus: 2-s2.0-65449142086 (45)

11573/361898 - 2008 - Histone deacetylase inhibitors and hemoglobin F induction in beta-thalassemia
A. R., Migliaccio; Rotili, Dante; A., Nebbioso; G., Atweh; Mai, Antonello - 01a Articolo in rivista
paper: THE INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY (Applied Science Publishers:Ripple Road, Barking Essex United Kingdom) pp. 2341-2347 - issn: 1357-2725 - wos: WOS:000259134100002 (12) - scopus: 2-s2.0-48349094044 (16)

11573/363940 - 2008 - Identification of long chain alkylidenemalonates as novel small molecule modulators of histone acetyltransferases
Gianluca, Sbardella; Sabrina, Castellano; Caterina, Vicidomini; Rotili, Dante; Angela, Nebbioso; Marco, Miceli; Lucia, Altucci; Mai, Antonello - 01a Articolo in rivista
paper: BIOORGANIC & MEDICINAL CHEMISTRY LETTERS (Oxford: Pergamon, Amsterdam the Netherlands: Elsevier) pp. 2788-2792 - issn: 0960-894X - wos: WOS:000255444300005 (80) - scopus: 2-s2.0-42949089945 (86)

11573/358405 - 2008 - Nitric oxide modulates chromatin folding in human endothelial cells via protein phosphatase 2A activation and class II histone deacetylases nuclear shuttling
Illi, B.; Dello Russo, Claudio; Colussi, C.; Rosati, J.; Pallaoro, M.; Spallotta, F.; Rotili, Dante; Valente, Sergio; Ragone, G.; Martelli, F.; Biglioli, P.; Steinkuhler, C.; Gallinari, P.; Mai, Antonello; Capogrossi, M. C.; Gaetano, C. - 01a Articolo in rivista
paper: CIRCULATION RESEARCH (Lippincott, Williams & Wilkins:530 Walnut Street:Philadelphia, PA 19106:(800)638-3030, (301)223-2300, EMAIL: orders@lww.com, INTERNET: http://www.lww.com, Fax: (301)223-2320, (301)223-2320 PRimo editore: Baltimore, Md. : Grune & Stratton, c1953-) pp. 51-58 - issn: 0009-7330 - wos: WOS:000252217400009 (95) - scopus: 2-s2.0-37849010584 (99)

11573/363936 - 2008 - Novel uracil-based 2-aminoanilide and 2-aminoanilide-like derivatives: Histone deacetylase inhibition and in-cell activities
Mai, Antonello; Andrea, Perrone; Angela, Nebbioso; Rotili, Dante; Valente, Sergio; Maria, Tardugno; Silvio, Massa; Floriana De, Bellis; Lucia, Altucci - 01a Articolo in rivista
paper: BIOORGANIC & MEDICINAL CHEMISTRY LETTERS (Oxford: Pergamon, Amsterdam the Netherlands: Elsevier) pp. 2530-2535 - issn: 0960-894X - wos: WOS:000255246400002 (24) - scopus: 2-s2.0-41849089386 (27)

11573/363647 - 2008 - 5-Alkyl-6-benzyl-2-(2-oxo-2-phenylethylsulfanyl)pyrimidin-4(3H)-ones, a series of anti-HIV-1 agents of the dihydro-alkoxy-benzyl-oxopyrimidine family with peculiar structure-activity relationship profile.
Nawrozkij, Mb; Rotili, Dante; Tarantino, Domenico; Botta, G; Eremiychuk, As; Musmuca, Ira; Ragno, Rino; Samuele, A; Zanoli, S; Armand Ugón, M; Clotet Codina, I; Novakov, Ia; Orlinson, Bs; Maga, G; Esté, Ja; Artico, Marino; Mai, Antonello - 01a Articolo in rivista
paper: JOURNAL OF MEDICINAL CHEMISTRY (Washington, DC: American Chemical Society) pp. 4641-4652 - issn: 0022-2623 - wos: WOS:000258289800033 (53) - scopus: 2-s2.0-49449113636 (56)

11573/365241 - 2008 - Class II-selective histone deacetylase inhibitors. Part 2: Alignment-independent GRIND 3-D QSAR, homology and docking studies
Ragno, Rino; Silvia, Simeoni; Rotili, Dante; Antonella, Caroli; Giorgia, Botta; Gerald, Brosch; Silvio, Massa; Mai, Antonello - 01a Articolo in rivista
paper: EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY (Editions Scientifique & Medical Elsevier:23 Rue Linois, F 75724 Paris Cedex 15 France:011 33 1 71724646, INTERNET: http://www.elsevier.fr, Fax: 011 33 1 71724664) pp. 621-632 - issn: 0223-5234 - wos: WOS:000254777400019 (38) - scopus: 2-s2.0-40049110686 (46)

11573/362098 - 2008 - Substrate-induced stable enzyme-inhibitor complex formation allows tight binding of novel 2-aminopyrimidin-4(3H)-ones to drug-resistant HIV-1 reverse transcriptase mutants.
Samuele, A; Facchini, M; Rotili, Dante; Mai, Antonello; Artico, Marino; Armand Ugón, M; Esté, Ja; Maga, G. - 01a Articolo in rivista
paper: CHEMMEDCHEM (Weinheim : Wiley-VCH-Verl..) pp. 1412-1418 - issn: 1860-7179 - wos: WOS:000259628300014 (9) - scopus: 2-s2.0-54849438319 (9)

11573/363321 - 2007 - Synthesis and biological properties of novel 2-aminopyrimidin-4(3H)-ones highly potent against HIV-1 mutant strains
Mai, Antonello; Artico, Marino; Rotili, Dante; Tarantino, Domenico; Clotet Codina, I; Armand Ugón, M; Ragno, Rino; Simeoni, S; Sbardella, G; Nawrozkij, M. B.; Samuele, A; Maga, G; Esté, J. A. - 01a Articolo in rivista
paper: JOURNAL OF MEDICINAL CHEMISTRY (Washington, DC: American Chemical Society) pp. 5412-5424 - issn: 0022-2623 - wos: WOS:000250557100019 (58) - scopus: 2-s2.0-35848949355 (62)

11573/362130 - 2007 - Identification of two new synthetic histone deacetylase inhibitors that modulate globin gene expression in erythroid cells from healthy donors and patients with thalassemia
Mai, Antonello; K., Jelicic; Rotili, Dante; A., Di Noia; E., Alfani; Valente, Sergio; L., Altucci; A., Nebbioso; S., Massa; R., Galanello; G., Brosch; A. R., Migliaccio; G., Migliaccio - 01a Articolo in rivista
paper: MOLECULAR PHARMACOLOGY (American Society for Pharmacology and Experimental Therapeutics:9650 Rockville Pike:Bethesda, MD 20814:(301)530-7024, EMAIL: pstoute@aspet.org, INTERNET: http://www.aspet.org, Fax: (301)634-7099) pp. 1111-1123 - issn: 0026-895X - wos: WOS:000250385300004 (29) - scopus: 2-s2.0-35548933854 (30)

11573/365178 - 2007 - Discovery of uracil-based histone deacetylase inhibitors able to reduce acquired antifungal resistance and trailing growth in Candida albicans
Mai, Antonello; Rotili, Dante; Massa, Silvio; Gerald, Brosch; Simonetti, Giovanna; Passariello, Claudio; Palamara, Anna Teresa - 01a Articolo in rivista
paper: BIOORGANIC & MEDICINAL CHEMISTRY LETTERS (Oxford: Pergamon, Amsterdam the Netherlands: Elsevier) pp. 1221-1225 - issn: 0960-894X - wos: WOS:000244943300017 (78) - scopus: 2-s2.0-33846938126 (82)

11573/364545 - 2007 - Novel pyrrole-containing histone deacetylase inhibitors endowed with cytodifferentiation activity
Mai, Antonello; Valente, Sergio; Rotili, Dante; Silvio, Massa; Giorgia, Botta; Gerald, Brosch; Marco, Miceli; Angela, Nebbioso; Lucia, Altucci - 01a Articolo in rivista
paper: THE INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY (Applied Science Publishers:Ripple Road, Barking Essex United Kingdom) pp. 1510-1522 - issn: 1357-2725 - wos: WOS:000248566700025 (14) - scopus: 2-s2.0-34447268739 (14)

11573/51617 - 2007 - Docking and 3-D QSAR Studies on SIRT2 Inhibitors: A GRID/GOLPE Approach on Different Series of Compounds.
Ragno, Rino; Mai, Antonello; Simeoni, Silvia; Caroli, Antonia; Rotili, Dante; Botta, Giorgia - 04a Atto di comunicazione a congresso
conference: Frontiers in CNS and Oncology Medicinal Chemistry, ACS-EFMC (Siena, Italy)
book: Frontiers in CNS and Oncology Medicinal Chemistry, ACS-EFMC - ()

11573/361993 - 2007 - Slow-, tight-binding HIV-1 reverse transcriptase non-nucleoside inhibitors highly active against drug-resistant mutants
Reynel, Cancio; Mai, Antonello; Rotili, Dante; Marino, Artico; Gianluca, Sbardella; Imma Clotet, Codina; José A, Este; Emmanuele, Crespan; Samantha, Zanoli; Ulrich, Hubscher; Silvio, Spadari; Giovanni, Maga - 01a Articolo in rivista
paper: CHEMMEDCHEM (Weinheim : Wiley-VCH-Verl..) pp. 445-448 - issn: 1860-7179 - wos: WOS:000246011500006 (20) - scopus: 2-s2.0-34547939030 (22)

11573/362194 - 2007 - Histone deacetylase inhibitors may reduce pathogenicity and virulence in Candida albicans
Simonetti, Giovanna; Passariello, Claudio; Rotili, Dante; Mai, Antonello; Enrico, Garaci; Palamara, Anna Teresa - 01a Articolo in rivista
paper: FEMS YEAST RESEARCH (Elsevier BV:PO Box 211, 1000 AE Amsterdam Netherlands:011 31 20 4853757, 011 31 20 4853642, 011 31 20 4853641, EMAIL: nlinfo-f@elsevier.nl, INTERNET: http://www.elsevier.nl, Fax: 011 31 20 4853598) pp. 1371-1380 - issn: 1567-1356 - wos: WOS:000250298000018 (37) - scopus: 2-s2.0-35448985401 (38)

11573/362375 - 2006 - Analytical and semipreparative high performance liquid chromatography separation of stereoisomers of novel 3,4-dihydropyrimidin-4(3H)-one derivatives on the immobilised amylose-based Chiralpack IA chiral stationary phase.
Cirilli, R; Ferretti, R; Gallinella, B; La Torre, F; Mai, Antonello; Rotili, Dante - 01a Articolo in rivista
paper: JOURNAL OF SEPARATION SCIENCE (Wiley-VCH Verlag GmBH:PO Box 101161, D 69451 Weinheim Germany:011 49 6201 606147, EMAIL: service@wiley-vch.de, INTERNET: http://www.wiley-vch.de, Fax: 011 49 6201 606328) pp. 1399-1406 - issn: 1615-9306 - wos: WOS:000239291200011 (27) - scopus: 2-s2.0-33746470231 (29)

11573/12854 - 2006 - Identification of small molecules inhibitors of GCN5 histone acetyltransferase activity
Mai, Antonello; Rotili, Dante; Ornaghi, P; Tosi, F; Vicidomini, C; Sbardella, G; Nebbioso, A; Altucci, L; Filetici, P. - 01a Articolo in rivista
paper: ARKIVOC (ARKAT USA INC, C/O ALAN R KATRITZKY, UNIV FLORIDA, DEPT CHEMISTRY, PO BOX 117200, GAINESVILLE, USA, FL, 32611) pp. 24-37 - issn: 1551-7004 - wos: WOS:000242574600004 (6) - scopus: 2-s2.0-33744470562 (7)

11573/358996 - 2006 - Small-Molecule Inhibitors of Histone Acetyltransferase Activity: Identification and Biological Properties
Mai, Antonello; Rotili, Dante; Tarantino, D; Ornaghi, P; Tosi, F; Vicidomini, C; Sbardella, Gianluca; Nebbioso, A; Miceli, M; Altucci, L; Filetici, P. - 01a Articolo in rivista
paper: JOURNAL OF MEDICINAL CHEMISTRY (Washington, DC: American Chemical Society) pp. 6897-6907 - issn: 0022-2623 - wos: WOS:000241894000031 (118) - scopus: 2-s2.0-33750989910 (125)

11573/363353 - 2006 - Synthesis and biological properties of novel, uracil-containing histone deacetylase inhibitors
Mai, Antonello; Silvio, Massa; Rotili, Dante; Silvia, Simeoni; Ragno, Rino; Giorgia, Botta; Angela, Nebbioso; Marco, Miceli; Lucia, Altucci; Gerald, Brosch - 01a Articolo in rivista
paper: JOURNAL OF MEDICINAL CHEMISTRY (Washington, DC: American Chemical Society) pp. 6046-6056 - issn: 0022-2623 - wos: WOS:000240826200019 (57) - scopus: 2-s2.0-33749258885 (56)

11573/366703 - 2006 - One-Pot, High Yielding Synthesis of Novel Dihydrothiazolo[3,2-a]pyrimidinones
Rotili, Dante; Mai, Antonello; Ambrogio, I; G., Fabrizi - 01a Articolo in rivista
paper: SYNTHETIC COMMUNICATIONS (New York, NY : Taylor & Francis New York, NY: Marcel Dekker Incorporated) pp. 495-500 - issn: 0039-7911 - wos: WOS:000234819600013 (0) - scopus: 2-s2.0-31744445689 (1)

11573/363623 - 2006 - 6-Alkylthio-4-[1-(2,6-difluorophenyl)alkyl]-1H-[1,3,5]triazin-2-ones (ADATs): Novel Regulators of Cell Differentiation and Proliferation
Sbardella, G; Bartolini, S; Castellano, S; Artico, Marino; Paesano, N; Rotili, Dante; Spadafora, C; Mai, Antonello - 01a Articolo in rivista
paper: CHEMMEDCHEM (Weinheim : Wiley-VCH-Verl..) pp. 1073-1080 - issn: 1860-7179 - wos: WOS:000202946300006 (13) - scopus: 2-s2.0-33750284393 (14)

11573/526020 - 2005 - Histone Deacetylation in Epigenetics: An Attractive Target for Anticancer Therapy
Mai, Antonello; Massa, S; Rotili, Dante; Cerbara, I; Valente, Sergio; Pezzi, R; Simeoni, S; Ragno, Rino - 01a Articolo in rivista
paper: MEDICINAL RESEARCH REVIEWS (John Wiley & Sons Incorporated:Customer Service, 111 River Street:Hoboken, NJ 07030:(800)225-5945, (201)748-6000, EMAIL: societyinfo@wiley.com, INTERNET: http://www.wiley.com, Fax: (212)748-6551) pp. 261-309 - issn: 0198-6325 - wos: WOS:000228224900001 (297) - scopus: 2-s2.0-16844362441 (313)

11573/364675 - 2005 - Class II (IIa)-selective histone deacetylase inhibitors. 1. Synthesis and biological evaluation of novel (aryloxopropenyl)pyrrolyl hydroxyamides
Mai, Antonello; Silvio, Massa; Riccardo, Pezzi; Silvia, Simeoni; Rotili, Dante; Angela, Nebbioso; Annamaria, Scognamiglio; Lucia, Altucci; Peter, Loidl; Gerald, Brosch - 01a Articolo in rivista
paper: JOURNAL OF MEDICINAL CHEMISTRY (Washington, DC: American Chemical Society) pp. 3344-3353 - issn: 0022-2623 - wos: WOS:000228871700031 (186) - scopus: 2-s2.0-20944435415 (193)

11573/364679 - 2005 - Exploring the connection unit in the HDAC inhibitor pharmacophore model: Novel uracil-based hydroxamates
Mai, Antonello; Silvio, Massa; Rotili, Dante; Riccardo, Pezzi; Patrizia, Bottoni; Roberto, Scatena; Joachim, Meraner; Gerald, Brosch - 01a Articolo in rivista
paper: BIOORGANIC & MEDICINAL CHEMISTRY LETTERS (Oxford: Pergamon, Amsterdam the Netherlands: Elsevier) pp. 4656-4661 - issn: 0960-894X - wos: WOS:000232465900002 (42) - scopus: 2-s2.0-25144444434 (44)

11573/363627 - 2005 - A novel Gcn5p inhibitor represses cell growth, gene transcription and histone acetylation in budding yeast
Prisca, Ornaghi; Rotili, Dante; Gianluca, Sbardella; Mai, Antonello; Patrizia, Filetici - 01a Articolo in rivista
paper: BIOCHEMICAL PHARMACOLOGY (-Oxford, United Kingdom: Elsevier Science Limited -London ; New York : Pergamon Press, 1958-) pp. 911-917 - issn: 0006-2952 - wos: WOS:000231663100011 (35) - scopus: 2-s2.0-23744453206 (37)

11573/364674 - 2005 - 6-[1-(2,6-difluorophenyl)ethyl]pyrimidinones antagonize cell proliferation and induce cell differentiation by inhibiting (a nontelomeric) endogenous reverse transcriptase
Sara, Bartolini; Mai, Antonello; Artico, Marino; Nicola, Paesano; Rotili, Dante; Corrado, Spadafora; Gianluca, Sbardella - 01a Articolo in rivista
paper: JOURNAL OF MEDICINAL CHEMISTRY (Washington, DC: American Chemical Society) pp. 6776-6778 - issn: 0022-2623 - wos: WOS:000233017300003 (51) - scopus: 2-s2.0-27444434731 (51)

11573/189567 - 2004 - Synthesis and evaluation of sirtinol analogues as yeast Sir2 and human SIRT inhibitors
Pezzi, R.; Rotili, D.; Simeoni, S.; Ragno, Rino; Mariotti, Francesca Romana; Chiani, Francesco; Camilloni, Giorgio; Massa, S.; Mai, Antonello - 04a Atto di comunicazione a congresso
book: XVIII International Symposium on Medicinal Chemistry - ()

11573/366839 - 2003 - Discovery of (Aryloxo propenyl)pyrrolyl Hydroxyamides as Selective Inhibitors of Class IIa Histone Deacetylase Homologue HD1-A
Mai, Antonello; Massa, S.; Pezzi, R.; Rotili, Dante; Loidl, P.; Brosch, G. - 01a Articolo in rivista
paper: JOURNAL OF MEDICINAL CHEMISTRY (Washington, DC: American Chemical Society) pp. 4826-4829 - issn: 0022-2623 - wos: WOS:000186347400004 (61) - scopus: 2-s2.0-0242362600 (65)

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