Phd in PHD PROGRAM IN BEHAVIORAL NEUROSCIENCE

email: daniele.caprioli@uniroma1.it
phone: (+39) 06 4991 2515
building: Edificio CU024 – Piano I
room: 28

Part I - General Information:
Full Name: Daniele Caprioli
Citizenship: Italian
Office phone number: +39 06 4991 2515
E-mail: daniele.caprioli@uniroma1.it or daniele.caprioli@nih.gov or daniele.caprioli@gmail.com
Spoken Languages: Italian and English


Part II - Education
School and location Degree Year Field
Sapienza, University of Rome, Rome, Italy M.Sc. 2004 General and Experimental Psychology
Sapienza, University of Rome, Rome, Italy Ph.D. Dec 2008 Pharmacology


Part III - Appointments
2016-current Assistant Professor, Department of Physiology and Pharmacology, Sapienza University of Rome, Rome, IT
2017-current Researcher, Laboratory of Neurobiology and Behavior, Santa Lucia Foundation (IRCCS Fondazione Santa Lucia)

Job Offers
2016 (Declined) CR1 (chargé de recherche de 1ère classe; with Tenure), University of Bordeaux, Neuroscience Campus, Bordeaux, FR

Previous positions
Dec 2008-2013 Research Associate, Department of Psychology, University of Cambridge, Cambridge, UK
2013-2016 Post-doctoral Fellow, Behavioral Neuroscience Branch, IRP/NIDA/NIH, Baltimore, MD, USA

Other Appointments
1988-1998 Professional waterpolo Goalkeeper at ‘Fiamme Oro’ team
1998-2008 Police officer in the Forensic Science Team in Rome, Italy


Part IV - Teaching Experience
2004-2008 Seminars of Neuropsychopharmacology in the Psychiatry Residency Program; Seminars Pharmacology in the Dentistry Program (M.Sc.) at Sapienza, University of Rome, Rome, Italy

2008-2013 Supervision of Part II students (third Year Bachelor’s degree) in Behavioral Neuroscience and Psychopharmacology at University of Cambridge, Cambridge, UK

2013-2016 Supervision of “Post-Baccalaureate” in Behavioral Neuroscience and Psychopharmacology;

Supervision of the PhD candidate Marco Venniro from the Graduate Partnership Program between NIH and University of Verona, dissertation title “Neuronal mechanisms of cue induced methamphetamine seeking after voluntary abstinence” Graduated – 2016 (with honors)

2016-2017 Pharmacology (code 1036298) – M.Sc. in Health Professions of Technical Sciences.
Pharmacology (code 1035053) – M.Sc. in First Aid
Grant Writing (code DOT1326P4) – PhD program in Behavioral Neuroscience

2017-2018 Pharmacology (code 1036298) – M.Sc. in Health Professions of Technical Sciences.
Pharmacology (code 1035053) – M.Sc. in First Aid
Pharmacology (code 1035808) – B.A. Biomedical Laboratory Techniques
Pharmacology (code 1056296) – B.A. Orthopaedics Techniques
Neuropharmacology of motivational processes (code 1052232) – M.Sc. in Neurobiology
Grant Writing (code DOT1326P4C) – PhD program in Behavioral Neuroscience

Supervision of the PhD candidate Ludovica Maddalena Rossi from Sapienza, University of Rome, dissertation title “to be defined”


Part V - Society membership, awards and honors, ad-hoc reviewer journals
Membership
2004-current Member of the Society for Neuroscience
2004-current Member of the European Behavioral Pharmacology Society (since 2017 Member of the Full Committee)
2004-current Member of the Federation of European Neuroscience Societies
2015-current Member of F1000
2017-current Member of the Italian Society of Pharmacology

Travel awards
2007 European Behavioral Pharmacology Society (EBPS) Travel Award, Tuebingen (D)
2013 European Behavioral Pharmacology Society (EBPS) Travel Award, La Rochelle (FR)
2015 EBPS/EBBS Travel Award, Verona (IT)

Other awards and honors
2008 Fellowship Fondazione Sovena, Rome, Italy
2014 Fellows Award for Research Excellence (NIH), Bethesda, MD, USA
2015 Postdoctoral Fellow Mentoring Award (NIDA), Baltimore, MD, USA
2016 Fellows Award for Research Excellence (NIH), Bethesda, MD, USA

Ad-hoc reviewer:
Scientific journals: Molecular Psychiatry, Biological Psychiatry, Neuropsychopharmacology, Journal of Neuroscience, Journal of Neuroscience Methods, Addiction Biology, European Journal of Neuroscience, Psychopharmacology, Behavioral Neuroscience, PlosOne, Addiction, Physhiology and Behavior, Neuroscience and Biobehavioral Review, Trends in Molecular Medicine.

Grant agencies : Agencie Nationale de la Recherche, France; Ministero dell’Istruzione, dell’Universita’ e della Ricerca- RIPRISE, Italy


Part VI - Research Activities
Keywords:
drug addiction, decision making, ADHD, impulsivity, discrete choice, cocaine, methamphetamine, heroin, drug relapse, craving, dopamine, nucleus accumbens, amygdala, MRI, PET, Ca2+ imaging

Brief description:
My academic expertise is in the pharmacology and neuroscience of drug addiction, with a focus on neurobiology of drug relapse. This interest is rooted in the fact that the major challenge in treating addiction is to prevent relapse to drug use during abstinence. Moreover, research on neural substrates of drug relapse has yet to be translated into significant advances in addiction treatment. Thus, the major aim of my research is to elucidate the behavioral, environmental, and neural mechanisms underlying drug relapse.

My multidisciplinary approach combines behavioral, cognitive, neuropharmacological, chemogenetic, and anatomical techniques in rats. I follow up on correlative measures of neuronal activity with causal demonstrations, using intracranial injections of pharmacological agents, messenger RNA interference, or state-of-the-art chemogenetic DREADD methods.

I have experience in the techniques required to complete standard behavioral neuroscience projects. This includes behavioral tasks, perfusions, as well as intracranial and intravenous surgery, immunohistochemical assays, retrograde tracing, and viral injections (for optogenetic and chemogenetic manipulations).


Part VII - Scientific achievements
Research Reports
1. Venniro M, Zhang M, Caprioli D, Hoots JK, Golden SA, Heins C, Morales M, Epstein DH, Shaham Y (2018) Volitional social interaction prevents drug addiction in rat models Nat Neurosci 21(11), 1520-1529
2. Rubio FJ, Quintana-Feliciano R, Warren BL, Li X, Witonsky KFR, Valle FSD, Selvam PV, Caprioli D, Venniro M, Bossert JM, Shaham Y, Hope BT (2018) Prelimbic cortex is a common brain area activated during cue-induced reinstatement of cocaine and heroin seeking in a polydrug self-administration rat model Eur J Neurosci 49(2), 165-178
3. Venniro M, Caprioli D, Zhang M, Whitaker LR, Zhang S, Wang H, Warren BL, Cifani C, Marchant NJ, Yizhar O, Bossert JM, Chiamulera C, Morales M, Shaham Y (2017) Inhibition of the anterior insula projection to central amygdala decreases relapse after contingency management Neuron 96(2), 414-427
4. Golden SA, Heins C, Venniro M, Caprioli D, Zhang M, Epstein D, Shaham Y (2017) Compulsive “addiction-like” aggressive behavior in mice Biol Psychiatry 82(4), 239-248
5. Caprioli D, Venniro M, Zhang M, Bossert JM, Warren B, Hope B, Shaham Y (2017) Role of dorsomedial striatum neuronal ensembles in incubation of methamphetamine craving after voluntary abstinence J Neurosci 37(4), 1014-1027
6. Venniro M, Zhang M, Shaham Y, Caprioli D (2017) Incubation of methamphetamine but not heroin craving after voluntary abstinence in male and female rats Neuropshychopharmacology 42(5), 1126-1135
7. Warren BL, Mendoza MP, Cruz FC, Leao RM, Rubio FJ, Whitaker LR, McPherson KB, Bossert JM, Caprioli D, Shaham Y, Hope BT (2016) Distinct Fos-expressing neuronal ensembles in the ventromedial prefrontal cortex mediate food reward memories and extinction memories J Neurosci 36(25), 6691-703
8. Adhikary S, Caprioli D, Venniro M, Kallenberger P, Shaham Y, Bossert JM (2016) Incubation of extinction responding and cue-induced reinstatement, but not context- or drug priming-induced reinstatement, after withdrawal from methamphetamine Addict Biol 22(4), 977-990
9. Sawiak SJ, Jupp B, Howett D, Taylor T, Caprioli D, Carpenter TA, Dalley JW (2015) In vivo γ-amino-butyric acid measurement in rats with spectral editing at 4.7T J Magn Reson Imaging 43(6), 1308-12
10. Belin D, Belin-Rauscent A, Daniel ML, Puaud M, Jupp B, Sawiak SJ, Howett D, McKenzie C, Caprioli D, Besson M, RobbinsTW, Everitt BJ, DalleyJW (2016) From impulses to maladaptive actions: the insula is a neurobiological gate for the development of compulsive behavior Mol Psychiatry 21(4), 491-9
11. Caprioli D, Venniro M, Zeric T, Li X, Adhikary S, Madangopal R, Marchant NJ, Lucantonio F, Schoenbaum G, Bossert JM, Shaham Y (2015) Effect of the Novel Positive Allosteric Modulator of Metabotropic Glutamate Receptor 2 AZD8529 on Incubation of Methamphetamine Craving After Prolonged Voluntary Abstinence in a Rat Model Biol Psychiatry 78(7), 463-473
12. Caprioli D, Jupp B, Hong YT, Sawiak SJ, Ferrari V, Wharton L, Williamson DJ, McNabb C, Berry D, Aigbirhio FI, Robbins TW, Fryer TD, Dalley JW (2015) Dissociable rate-dependent effects of oral methylphenidate on impulsivity and D2/3 receptor availability in the striatum J Neurosci 35(9), 3747-3755
13. Caprioli D, Zeric T, Thorndike EB, Venniro M (2015) Persistent palatable food preference in rats with a history of limited and extended access to methamphetamine self-administration Addict Biol 20(5), 913-926
14. Barnes SA, Sawiak SJ, Caprioli D, Jupp B, Buonincontri G, Mar AC, Harte MK, Fletcher PC, Robbins TW, Neill JC, Dalley JW (2015) Impaired limbic cortico-striatal structure and sustained visual attention in a rodent model of schizophrenia Int J Neuropsychopharmacol 18(2) 31;18(2) pii: pyu010
15. Marchant NJ, Rabei R, Kaganovsky K, Caprioli D, Bossert JM, Bonci A, Shaham Y (2014) A critical role of lateral hypothalamus in context-induced relapse to alcohol seeking after punishment-imposed abstinence J Neurosci 34(22), 7447-7457
16. Kumakura Y, Gjedde A, Caprioli D, Kienast T, Beck A, Plotkin M, Schlagenhauf F, Vernaleken I, Grunder G., Bartenstein P, Heinz A, Cumming P (2013) Increased turnover of dopamine in caudate nucleus of detoxified alcoholic patients PLoS One 8(9):e73903
17. Caprioli D, Sawiak SJ, Merlo E, Theobald DE, Spoelder M, Jupp B, Voon V, Carpenter TA, Everitt BJ, Robbins TW, Dalley JW (2014) Gamma aminobutyric acidergic and neuronal structural markers in the nucleus accumbens core underlie trait-like impulsive behavior Biol Psychiatry 75(2), 115-123
18. Virdee K, McArthur S, Brischoux F, Caprioli D, Ungless MA, Robbins TW, Dalley JW, Gillies GE (2014) Antenatal glucocorticoid treatment induces adaptations in adult midbrain dopamine neurons, which underpin sexually dimorphic behavioral resilience Neuropsychopharmacology 39(2), 339-350
19. Voon V, Irvine MA, Derbyshire K, Worbe Y, Lange I, Abbott S, Morein-Zamir S, Dudley R, Caprioli D, Harrison NA, Wood J, Dalley JW, Bullmore ET, Grant JE, Robbins TW (2014) Measuring "waiting" impulsivity in substance addictions and binge eating disorder in a novel analogue of rodent serial reaction time task Biol Psychiatry 75(2), 148-155
20. Moreno M, Economidou D, Mar AC, Lopez-Granero C, Caprioli D, Theobald DE, Fernando A, Newman AH, Robbins TW, Dalley JW (2013) Divergent effects of D(2)/(3) receptor activation in the nucleus accumbens core and shell on impulsivity and locomotor activity in high and low impulsive rats. Psychopharmacology (Berl) 228(1), 19-30
21. Caprioli D, Hong, YT, Sawiak SJ, Ferrari V, Williamson DJ, Jupp B, Carpenter AT, Aigbirhio FI, Everitt BJ, Robbins TW, Fryer, TD, Dalley JW (2013) Baseline-dependent effects of cocaine pre-exposure on impulsivity and D2/3 receptor availability in the rat striatum: possible relevance to the attention-deficit hyperactivity syndrome Neuropsychopharmacology 38(8), 1460-1471
22. Jupp B, Caprioli D, Saigal N, Reverte I, Shrestha S, Cumming P, Everitt BJ, Robbins TW, Dalley JW (2013) Dopaminergic and GABA-ergic markers of impulsivity in rats: evidence for anatomical localisation in ventral striatum and prefrontal cortex Eur J Neurosci 37(9), 1519-1528
23. Riss PJ, Hong YT, Marton J, Caprioli D, Williamson DJ, Ferrari V, Saigal N, Roth BL, Henriksen G, Fryer TD, Dalley JW, Aigbirhio FI (2013) Synthesis and evaluation of 18F-FE-PEO in rodents: an 18F-labeled full agonist for opioid receptor imaging J Nucl Med 54(2), 299-305
24. Fernando AB, Economidou D, Theobald DE, Zou MF, Newman AH, Spoelder M, Caprioli D, Moreno M, Hipolito L, Aspinall AT, Robbins TW, Dalley JW (2012) Modulation of high impulsivity and attentional performance in rats by selective direct and indirect dopaminergic and noradrenergic receptor agonists Psychopharmacology (Berl) 219(2), 341-352
25. Riss PJ, Hong YT, Williamson D, Caprioli D, Sitnikov S, Ferrari V, Sawiak SJ, Baron JC, Dalley JW, Fryer TD, Aigbirhio FI (2011) Validation and quantification of [18F]altanserin binding in the rat brain using blood input and reference tissue modeling J Cereb Blood Flow Metab 31(12), 2334-2342
26. Molander AC, Mar A, Norbury A, Steventon S, Moreno M, Caprioli D, Theobald DE, Belin D, Everitt BJ, Robbins TW, Dalley JW (2011) High impulsivity predicting vulnerability to cocaine addiction in rats: some relationship with novelty preference but not novelty reactivity, anxiety or stress. Psychopharmacology (Berl) 215(4), 721-731
27. Bari A, Theobald DE, Caprioli D, Mar AC, Aidoo-Micah A, Dalley JW, Robbins TW (2010) Serotonin modulates sensitivity to reward and negative feedback in a probabilistic reversal learning task in rats Neuropsychopharmacology 35(6), 1290-1301
28. Caprioli D, Celentano M, Dubla A, Lucantonio F, Nencini P, Badiani A (2009) Ambience and drug choice: cocaine- and heroin-taking as a function of environmental context in humans and rats Biol Psychiatry 65(10), 893-899
29. Celentano M, Caprioli D, Dipasquale P, Cardillo V, Nencini P, Gaetani S, Badiani A (2009) Drug context differently regulates cocaine versus heroin self-administration and cocaine- versus heroin-induced Fos mRNA expression in the rat Psychopharmacology (Berl) 204(2), 349-360
30. Caprioli D, Celentano M, Paolone G, Lucantonio F, Bari A, Nencini P, Badiani A (2008) Opposite environmental regulation of heroin and amphetamine self-administration in the rat Psychopharmacology (Berl) 198(3), 395-404
31. Paolone G, Conversi D, Caprioli D, Bianco, PD, Nencini P, Cabib S, Badiani A (2007) Modulatory effect of environmental context and drug history on heroin-induced psychomotor activity and fos protein expression in the rat brain Neuropsychopharmacology 32(12), 2611-2623
32. Caprioli D, Paolone G, Celentano M, Testa A, Nencini P, Badiani A (2007) Environmental modulation of cocaine self-administration in the rat Psychopharmacology (Berl) 192(3), 397-406
33. Scaccianoce S, Del Bianco P, Paolone G, Caprioli D, Modafferi AM, Nencini P, Badiani A (2006) Social isolation selectively reduces hippocampal brain-derived neurotrophic factor without altering plasma corticosterone Behav Brain Res 168(2), 323-325
34. Antonilli L, Petecchia E, Caprioli D, Badiani A, Nencini P (2005) Effect of repeated administrations of heroin, naltrexone, methadone, and alcohol on morphine glucuronidation in the rat Psychopharmacology (Berl) 182(1), 58-64

Review Articles
1. Venniro M, Caprioli D, Shaham Y (2018) Novel models of drug relapse and craving after voluntary abstinence Neuropsychopharmacology 44(1), 234-235
2. Caprioli D, Justinova Z, Venniro M, Shaham Y (2018) Effect of novel allosteric modulators of metabotropic glutamate receptors on drug self-administration and relapse: a review of preclinical studies and their clinical implications Biol Psychiatry 84(3), 180-192
3. Venniro M, Caprioli D & Shaham Y (2015) Animal models of drug relapse and craving: from drug priming-induced reinstatement to incubation of craving after voluntary abstinence Progress in Brain Research Vol. 224:25-52
4. Li X, Caprioli, D & Marchant NJ (2014) Recent updates on incubation of drug craving: a mini-review Addict Biol 20(5), 872-6
5. Hayes DJ, Jupp B, Sawiak SJ, Merlo E, Caprioli D & Dalley JW (2014) Brain gamma-aminobutyric acid: a neglected role in impulsivity Eur J Neurosci 39(11), 1921-1932
6. Lucantonio F, Caprioli D & Schoenbaum G (2014) Transition from 'model-based' to 'model-free' behavioral control in addiction: Involvement of the orbitofrontal cortex and dorsolateral striatum Neuropharmacology 76 Pt B, 407-415
7. Caprioli D, Fryer TD, Sawiak SJ, Aigbirhio FI, Dalley JW (2013) Translating positron emission tomography studies in animals to stimulant addiction: promises and pitfalls Curr Opin Neurobiol 23(4), 597-606
8. Jupp B, Caprioli D & Dalley JW (2013) Highly impulsive rats: modelling an endophenotype to determine the neurobiological, genetic and environmental mechanisms of addiction Dis Model Mech 6(2), 302-311
9. McNabb CB, Russell BR, Caprioli D, Nutt DJ, Gibbons S, Dalley JW (2012) Single chemical entity legal highs: assessing the risk for long term harm Curr Drug Abuse Rev 5(4), 304-319
10. Virdee K., Cumming P, Caprioli D, Jupp B, Rominger A, Aigbirhio FI, Fryer TD, Riss PJ, Dalley JW (2012) Applications of positron emission tomography in animal models of neurological and neuropsychiatric disorders Neurosci Biobehav Rev 36(4), 1188-1216
11. Cumming P, Caprioli D & Dalley JW (2011) What have positron emission tomography and 'Zippy' told us about the neuropharmacology of drug addiction? Br J Pharmacol 163(8), 1586-1604
12. Caprioli D, Celentano M, Paolone G, Badiani A (2007) Modeling the role of environment in addiction. Prog Neuropsychopharmacol Biol Psychiatry 31(8), 1639-1653

Invited Commentaries and book chapters
1. Caprioli D, Calu D, Shaham Y (2014) Loss of phasic dopamine: a new addiction marker? Nat Neurosci, 17(5), 644-646
2. Badiani A, Caprioli D, Testa A, De Luca MT, Celentano M (2011) Environmental modulation of drug taking
In: Animal Models of Drug Addiction (Mary C Olmstead, ed), Humana Press, Vol. 53, pp 293-309

Invited Lectures
1. March 2018 ‘Modeling drug relapse’ University of Bordeaux, Bordeaux, FR
2. November 2017 ‘The Neurobiology of Abnormal Decision-Making Processes: Focus on Insula and Drug Craving’ Fondazione Santa Lucia, Rome, IT
3. October 2016 ‘Neural mechanisms underlying the incubation of methamphetamine craving after voluntary abstinence’ University of Sussex, Brighton, UK
4. March 2016 ‘Neural mechanisms underlying the incubation of methamphetamine craving after voluntary abstinence’ University of Bordeaux, Bordeaux, FR
5. January 2016 ‘Effect of the novel positive allosteric modulator of mGluR2 AZD8529 on incubation of methamphetamine craving after prolonged voluntary abstinence’, New Targets and Medication meeting, NIDA, Bethesda, USA
6. December 2015 ‘Neural mechanisms underlying the incubation of methamphetamine craving after voluntary abstinence’ NIAAA lecture seminar series, Bethesda, USA
7. October 2015 ‘Neural mechanisms of incubation of methamphetamine craving after prolonged voluntary abstinence’ SfN meeting in Chicago, USA
8. Septemeber 2015 ‘Effect of the novel positive allosteric modulator of mGluR2 AZD8529 on incubation of methamphetamine craving after prolonged voluntary abstinence’ Joint EBPS – EBBS meeting in Verona, Italy
9. Dec 2014 ‘Choice of palatable food versus drugs of abuse in the laboratory rat: implications for contingency management treatment in humans’ Seminar series at NIDA IRP, Baltimore, MD
10. July 2014 ‘Incubation of methamphetamine craving after prolonged self-imposed abstinence in a contingency management alternative-reward procedure’ Branch meeting of Markus Heilig, Clinical director of NIAAA/NIDA, Bethesda, MD
11. June 2012 ‘Translating positron emission tomography studies in animals to stimulant addiction: promises and pitfalls’ Discussion Group Semiar series, Director Trevor W. Robbins, University of Cambridge
12. Sept 2009 ‘Ambience and drug choice: cocaine- and heroin-taking as a function of environmental context in humans and rats’ Discussion Group Semiar series, Director Trevor W. Robbins, University of Cambridge
13. June 2005 ‘Environmental modulation of the psychomotor activating effects’ Italian Society of Pharmacology, 32° meeting, Naples, IT