Phd in PHD PROGRAM IN BEHAVIORAL NEUROSCIENCE

email: daniele.caprioli@uniroma1.it
phone: (+39) 06 4991 2515
building: Edificio CU024 – Piano I
room: 28

Part I - General Information:
Full Name: Daniele Caprioli
Citizenship: Italian
Permanent Address: Piazzale Aldo Moro 5, 00185, Rome, Italy
Mobile phone number: +39 331 7323688
Office phone number: +39 06 4991 2515
E-mail: daniele.caprioli@uniroma1.it or daniele.caprioli@gmail.com
Spoken Languages: Italian and English


Part II - Education
School and location Degree Year Field
Sapienza, University of Rome, Rome, Italy M.Sc. 2004 General and Experimental Psychology
Sapienza, University of Rome, Rome, Italy Ph.D. Dec 2008 Pharmacology


Part III - Appointments
2019-current Associate Professor, Department of Physiology and Pharmacology, Sapienza University of Rome, Rome, IT
2016-2019 Assistant Professor, Department of Physiology and Pharmacology, Sapienza University of Rome, Rome, IT
2017-current Researcher, Laboratory of Neurobiology and Behavior, Santa Lucia Foundation (IRCCS Fondazione Santa Lucia)

Job Offers
2016 (Declined) - CR1 (chargé de recherche de 1ère classe; with Tenure), University of Bordeaux, Neuroscience Campus, Bordeaux, FR

Previous positions
Dec 2008-2013 Research Associate, Department of Psychology, University of Cambridge, Cambridge, UK
2013-2016 Post-doctoral Fellow, Behavioral Neuroscience Branch, IRP/NIDA/NIH, Baltimore, MD, USA

Other Appointments
1988-1998 Professional waterpolo Goalkeeper at ‘Fiamme Oro’ team
1998-2008 Police officer in the Forensic Science Team in Rome, Italy


Part IV - Teaching Experience
2004-2008 Seminars of Neuropsychopharmacology in the Psychiatry Residency Program; Seminars Pharmacology in the Dentistry Program (M.Sc.) at Sapienza, University of Rome, Rome, Italy

2008-2013 Supervision of Part II students (third Year Bachelor’s degree) in Behavioral Neuroscience and Psychopharmacology at University of Cambridge, Cambridge, UK

2013-2016 Supervision of “Post-Baccalaureate” in Behavioral Neuroscience and Psychopharmacology;

Supervision of the PhD candidate Marco Venniro from the Graduate Partnership Program between NIH and University of Verona, dissertation title “Neuronal mechanisms of cue induced methamphetamine seeking after voluntary abstinence” Graduated – 2016 (with honors)

2016-current Pharmacology (code 1036298) – M.Sc. in Health Professions of Technical Sciences.
Pharmacology (code 1035053) – M.Sc. in First Aid
Grant Writing (code DOT1326P4) – PhD program in Behavioral Neuroscience

2017-current Pharmacology (code 1035808) – B.A. Biomedical Laboratory Techniques
Pharmacology (code 1056296) – B.A. Orthopedics Techniques
Neuropharmacology of motivational processes (code 1052232) – M.Sc. in Neurobiology
Grant Writing (code DOT1326P4C) – PhD program in Behavioral Neuroscience

Co-Supervision of the PhD candidate Marco Venniro from University of
Verona, dissertation title “Inhibition of the anterior insula projection to central amygdala
decreases relapse after contingency management” *Dissertation 2017

Supervision of the PhD candidate Ludovica Maddalena Rossi from Sapienza, University of
Rome, dissertation title “The role of the nucleus accumbens in the incubation of
methamphetamine craving after voluntary abstinence” *Dissertation 2019

Supervision of the PhD candidate Ginevra D’Ottavio from Sapienza, University of
Rome, dissertation title “to be defined”

Supervision of the PhD candidate Azka Khan from Sapienza, University of
Rome, dissertation title “to be defined”

Supervision of the PhD candidate Claudia Marchetti from Sapienza, University of
Rome, dissertation title “to be defined”

External Advissor of the PhD candidate Aiendrila Roy from EMBL, Monterotondo, Rome,
dissertation title “to be defined”

2021-current Co-chair of Search Committee for faculty members:
- 2017PAE002 – winner: Giuseppe Battaglia
- 2020PAR020 – winner: Caterina Scuderi
- 2021RTDB023 – winner: Antonia Manduca

2023-2025 - Member of the Steer Committee for Doctoral Schools
Commissione istruttoria dottorati di ricerca (macroarea B)
(Decreto N. 135/2023 Prot. 0007189)

2023-2024 - Member of the Steer Committee for the School of Medicine and Pharmacy
Membro della Giunta di Facoltà di Medicina e Farmacologia
(Disposizione n. 65/2023 Prot. n. 457 del 08/02/2023)


Part V - Society membership, awards and honors, ad-hoc reviewer journals
Membership
2004-current Member of the Society for Neuroscience
2004-current Member of the European Behavioral Pharmacology Society (from 2017 to 2023 Member of the Full Committee)
2004-current Member of the Federation of European Neuroscience Societies
2015-current Member of F1000
2017-current Member of the Italian Society of Pharmacology

Travel awards
2007 European Behavioral Pharmacology Society (EBPS) Travel Award, (600 €) Tuebingen (D)
2013 European Behavioral Pharmacology Society (EBPS) Travel Award, (900 €) La Rochelle (FR)
2015 EBPS/EBBS Travel Award (500 €), Verona (IT)

Other awards and honors
2008 Fellowship Fondazione Sovena, (7,500 €), Rome, Italy
2014 Fellows Award for Research Excellence (NIH) (1,000 $), Bethesda, MD, USA
2015 Postdoctoral Fellow Mentoring Award (NIDA) (1,000 $), Baltimore, MD, USA
2016 Fellows Award for Research Excellence (NIH) (1,000 $), Bethesda, MD, USA
2023 Researcher Award, PR FSE 2023, (2,000 €) Regione Lazio, Rome, Italy

Ad-hoc reviewer:
Scientific journals: Molecular Psychiatry, Biological Psychiatry, Neuropsychopharmacology, Journal of Neuroscience, Journal of Neuroscience Methods, Addiction Biology, European Journal of Neuroscience (Reviewing editor), Psychopharmacology, Behavioral Neuroscience, PlosOne, Addiction, Physhiology and Behavior, Neuroscience and Biobehavioral Review, Trends in Molecular Medicine, Life Sciences, Brain Behavior and Immunity, Journal of Affective Disorders, Behavioural Brain Research, Current Pharmacology,
Frontiers in Psychiatry (Reviewing editor)

Grant agencies : Agencie Nationale de la Recherche, France; Ministero dell’Istruzione, dell’Universita’ e della Ricerca- RIPRISE, Italy


Part VI - Funding Information
2012 (funded, Principal Investigator; PI) A GABA-MRS investigation of hyper-impulsive rats. Behavioral and Clinical Neuroscience Institute, University of Cambridge, United Kingdom (9,600 £)
2017 (funded, PI, code 000126-2017;) Starting grant, Sapienza University of Rome, Italy (10,000 € + fully equipped behavioral lab = 100,000 €)
2017 (funded, PI, code RM11715C457665A1) Molecular mechanisms underlying incubation of methamphetamine craving after forced and voluntary abstinence. Fondi di Ateneo, Sapienza University of Rome Italy (13,000 €)
2017 (funded, Organizer, code CC21715C79D66C9E) Funding for the workshop entitled: Neurobiology of social behavior in health and disease. Fondi di Ateneo, Sapienza University of Rome, Italy (4,000 €)
2017 (funded, PI) Fondo per il finanziamento delle attività base di ricerca (FFABR), Italy (3,000 €)
2018 (funded I, code RG11816432C5E431) Role of oxytocin in pain-induced relapse into prescription opioid abuse. Fondi di Ateneo, Sapienza University of Rome, Italy (30,000 €)
2019 (funded, Co-PI, code 2017HPTFFC) Synaptic engrams in memory formation and recall. Progetti di Rilevante Interesse Nazionale (PRIN) (130,000 €)
2019 (funded, PI) The role of metabotropic glutamate receptor 1 in methamphetamine craving and relapse: from mechanisms to strategies for therapeutic intervention. Istituto Pasteur Italia, Fondazione Cenci Bolognetti (40,000 €)
2019 (funded, PI, code RM11916B0E316F23) Neurobehavioral mechanisms of incubation of craving after social-choice based voluntary abstinence from methamphetamine in rats. Fondi di Ateneo, Sapienza University of Rome Italy (34,477 €)
2020 (funded, Co-PI, code GA12017304B57377) Intravital two-photon microscopy coupled with electrophysiology setup: a unique tool to longitudinally study cell morphology and function in awake animal models. Grandi Attrezzature di Ateneo, Sapienza University of Rome Italy (546,000 €)
2020 (funded, I, code RG120172B8E2B021) Role of microglia on synaptic adaptations in the nucleus accumbens during abstinence from cocaine: from mechanisms to strategies for therapeutic interventions to prevent drug relapse. Fondi di Ateneo, Sapienza University of Rome Italy (74,477 €)
2021 (funded, Organizer, code CC22117A5D08ADF3) Funding for the workshop entitled: Spanning the spectrum of social behavior: towards more translationally relevant animal models. Fondi di Ateneo, Sapienza University of Rome, Italy (2,000 €) 12-01-2022  12-01-2023
2021 (funded, PI, code RG12117A864C773B) Molecular and circuit mechanism underlying the protective effect of volitional social interaction on methamphetamine craving. Fondi di Ateneo, Sapienza University of Rome Italy (68,787 €) 12-01-2022  12-01-2025
2021 (funded, PI, code RF-2021-12374450) Leveraging the neural mechanisms of social reward for drug relapse prevention in subjects with substance use disorder. Bando Ricerca Finalizzata 2021 Ministery of Health (450,000 €) 30-4-2023  30-04-2026
2022 (funded, Co-PI, code GA122181AFEB4283) High-throughput multiscale imaging of fixed and live biological samples. Grandi Attrezzature di Ateneo, Sapienza University of Rome Italy (669,800 €) 19-12-2022
2022 (funded, I, code 2022HTFEH5) Gene environment interactions in autism spectrum disorders: the role of microglia as a key towards new therapeutic strategies. Ministero Università e Ricerca, PRIN, Italy (282,089 €)
2022 (funded, PI, code P202274WPN) Heroin versus social preference: a step forward to understand mechanisms and neurocircuitries subserving opioid use disorder. Ministero Università e Ricerca, PRIN PNRR 2022, Italy (274,116 €)

Part VII - Research Activities
Keywords:
drug addiction, decision making, ADHD, impulsivity, discrete choice, cocaine, methamphetamine, heroin, drug relapse, craving, dopamine, nucleus accumbens, amygdala, MRI, PET, Ca2+ imaging

Brief description:
My academic expertise is in the pharmacology and neuroscience of drug addiction, with a focus on neurobiology of drug relapse. This interest is rooted in the fact that the major challenge in treating addiction is to prevent relapse to drug use during abstinence. Moreover, research on neural substrates of drug relapse has yet to be translated into significant advances in addiction treatment. Thus, the major aim of my research is to elucidate the behavioral, environmental, and neural mechanisms underlying drug relapse.

My multidisciplinary approach combines behavioral, cognitive, neuropharmacological, chemogenetic, and anatomical techniques in rats. I follow up on correlative measures of neuronal activity with causal demonstrations, using intracranial injections of pharmacological agents, messenger RNA interference, or state-of-the-art chemogenetic DREADD methods.

I have experience in the techniques required to complete standard behavioral neuroscience projects both at a preclinical and clinical level (I am the PI also in several clinical trials). This includes behavioral tasks, perfusions, as well as intracranial and intravenous surgery, immunohistochemical assays, retrograde tracing, and viral injections (for optogenetic and chemogenetic manipulations).


Part VIIIa - Scientific achievements
Research Reports
1. Milella MS, Petraccia L, Pirelli F, Foti G, Sapio M, Berardi R, Caprioli D, Pugliese F, Vivino G. (2024) Self-harm by single- and multi-agent medication poisoning in a retrospective analysis of a Poison Control Center database from January 2018 to December 2022 Pharmacoepidemiol Drug Saf 33(2):e5767 IF: 2.4
2. Papastrat KM, Lis CA, Caprioli D, Pickard H, Puche AC, Ramsey LA, Venniro M. (2024) Social odor choice buffers drug craving Neuropshychopharmacology 49(4):731-739 IF: 7.6
3. Reverte I, Marchetti C, Pezza S, Zenoni SF, Scaringi G, Ferrucci L, D'Ottavio G, Pignataro A, Andolina D, Raspa M, Scavizzi F, Venniro M, Ramsey LA, Gross C, Caprioli D, Ragozzino D (2024) Microglia-mediated calcium-permeable AMPAR accumulation in the nucleus accumbens drives hyperlocomotion during cocaine withdrawal Brain Behav Immun 115:535-542 IF: 15.1
4. D’Ottavio G, Reverte I, Ragozzino D, Meringolo M, Milella MS, Boix F, Venniro M, Badiani A, Caprioli D (2022) Increased heroin intake and relapse vulnerability in intermittent relative to continuous self-administration: Sex differences in rats British Journal of Pharmacology 180(7), 910-926 IF: 9.473
5. Basilico B, Ferrucci L, Ratano P, Golia MT, Grimaldi A, Rosito M, Ferretti V, Reverte I, Sanchini C, Marrone MC, Giubettini M, De Turris V, Salerno D, Garofalo S, St-Pierre MK, Carrier M, Renzi M, Pagani F, Modi B, Raspa M, Scavizzi F, Gross CT, Marinelli S,Tremblay ME, Caprioli D, Maggi L, Limatola C, Di Angelantonio S, Ragozzino D (2022) Microglia control glutamatergic synapses in the adult mouse hippocampus Glia 70(1), 173-195 IF: 8.073
6. Quintana-Feliciano R, Gobin C, Kane L, Sortman B, Rakela , Genovese A, Tunstall B, Caprioli D, Iñiguez S, and Warren BL (2021) Food-seeking behavior is mediated by Fos-expressing neuronal ensembles formed at first learning in rats eNeuro 8(2):ENEURO.0373-20.2021 IF: 4.36
7. Kane L, Venniro M, Quintana-Feliciano R, Madangopal R, Rubio FJ, Bossert JM, Caprioli D, Shaham Y, Hope BT, Warren BL (2020) Fos-expressing neuronal ensemble in rat ventromedial prefrontal cortex encodes cocaine seeking but not food seeking in rats Addiction Biology 26(3):e12943 IF: 4.093
8. Rossi LM, Reverte I, Ragozzino D, Badiani A, Venniro M, Caprioli D (2019) Role of nucleus accumbens core but not shell in incubation of methamphetamine craving after voluntary abstinence Neuropshychopharmacology 45(2), 256-265 IF: 8.294
9. Warren B, Kane L, Venniro M, Selvam P, Quintana-Feliciano R, Mendoza M, Madangopal R, Komer L, Whitaker L, Rubio J, Bossert J, Caprioli D, Shaham Y, Hope B (2019) Separate vmPFC ensembles control cocaine self-administration versus extinction in rats J Neurosci 39(37), 7394-7407 IF: 6.167
10. Venniro M, Zhang M, Caprioli D, Hoots JK, Golden SA, Heins C, Morales M, Epstein DH, Shaham Y (2018) Volitional social interaction prevents drug addiction in rat models Nat Neurosci 21(11), 1520-1529 IF: 24.884
11. Rubio FJ, Quintana-Feliciano R, Warren BL, Li X, Witonsky KFR, Valle FSD, Selvam PV, Caprioli D, Venniro M, Bossert JM, Shaham Y, Hope BT (2019) Prelimbic cortex is a common brain area activated during cue-induced reinstatement of cocaine and heroin seeking in a polydrug self-administration rat model Eur J Neurosci 49(2), 165-178 IF: 3.386
12. Venniro M, Caprioli D, Zhang M, Whitaker LR, Zhang S, Wang H, Warren BL, Cifani C, Marchant NJ, Yizhar O, Bossert JM, Chiamulera C, Morales M, Shaham Y (2017) The Anterior Insular Cortex→Central Amygdala Glutamatergic Pathway Is Critical to Relapse after Contingency Management Neuron 96(2), 414-427 IF: 17.173
13. Golden SA, Heins C, Venniro M, Caprioli D, Zhang M, Epstein D, Shaham Y (2017) Compulsive “addiction-like” aggressive behavior in mice Biol Psychiatry 82(4), 239-248 IF: 13.382
14. Caprioli D, Venniro M, Zhang M, Bossert JM, Warren B, Hope B, Shaham Y (2017) Role of dorsomedial striatum neuronal ensembles in incubation of methamphetamine craving after voluntary abstinence J Neurosci 37(4), 1014-1027 IF: 6.167
15. Venniro M, Zhang M, Shaham Y, Caprioli D (2017) Incubation of methamphetamine but not heroin craving after voluntary abstinence in male and female rats Neuropshychopharmacology 42(5), 1126-1135 IF: 8.294
16. Warren BL, Mendoza MP, Cruz FC, Leao RM, Rubio FJ, Whitaker LR, McPherson KB, Bossert JM, Caprioli D, Shaham Y, Hope BT (2016) Distinct Fos-expressing neuronal ensembles in the ventromedial prefrontal cortex mediate food reward memories and extinction memories J Neurosci 36(25), 6691-703 IF: 6.167
17. Belin-Rauscent A, Daniel ML, Puaud M, Jupp B, Sawiak S, Howett D, McKenzie C, Caprioli D, Besson M, Robbins TW, Everitt BJ, Dalley JW, Belin D (2016) Impulsivity is predicted by the thinness of the insular cortex in rats Mol Psychiatry 2016 21(4):445 IF: 13.437
18. Adhikary S, Caprioli D, Venniro M, Kallenberger P, Shaham Y, Bossert JM (2016) Incubation of extinction responding and cue-induced reinstatement, but not context- or drug priming-induced reinstatement, after withdrawal from methamphetamine Addict Biol 22(4), 977-990 IF: 4.093
19. Sawiak SJ, Jupp B, Howett D, Taylor T, Caprioli D, Carpenter TA, Dalley JW (2015) In vivo γ-amino-butyric acid measurement in rats with spectral editing at 4.7T J Magn Reson Imaging 43(6), 1308-12 IF: 4.813
20. Belin D, Belin-Rauscent A, Daniel ML, Puaud M, Jupp B, Sawiak SJ, Howett D, McKenzie C, Caprioli D, Besson M, RobbinsTW, Everitt BJ, DalleyJW (2016) From impulses to maladaptive actions: the insula is a neurobiological gate for the development of compulsive behavior Mol Psychiatry 21(4), 491-9 IF: 13.437
21. Caprioli D, Venniro M, Zeric T, Li X, Adhikary S, Madangopal R, Marchant NJ, Lucantonio F, Schoenbaum G, Bossert JM, Shaham Y (2015) Effect of the Novel Positive Allosteric Modulator of Metabotropic Glutamate Receptor 2 AZD8529 on Incubation of Methamphetamine Craving After Prolonged Voluntary Abstinence in a Rat Model Biol Psychiatry 78(7), 463-473 IF: 13.382
22. Caprioli D, Jupp B, Hong YT, Sawiak SJ, Ferrari V, Wharton L, Williamson DJ, McNabb C, Berry D, Aigbirhio FI, Robbins TW, Fryer TD, Dalley JW (2015) Dissociable rate-dependent effects of oral methylphenidate on impulsivity and D2/3 receptor availability in the striatum J Neurosci 35(9), 3747-3755 IF: 6.167
23. Caprioli D, Zeric T, Thorndike EB, Venniro M (2015) Persistent palatable food preference in rats with a history of limited and extended access to methamphetamine self-administration Addict Biol 20(5), 913-926 IF: 4.093
24. Barnes SA, Sawiak SJ, Caprioli D, Jupp B, Buonincontri G, Mar AC, Harte MK, Fletcher PC, Robbins TW, Neill JC, Dalley JW (2015) Impaired limbic cortico-striatal structure and sustained visual attention in a rodent model of schizophrenia Int J Neuropsychopharmacol 18(2) 31;18(2) pii: pyu010 IF: 5.176
25. Marchant NJ, Rabei R, Kaganovsky K, Caprioli D, Bossert JM, Bonci A, Shaham Y (2014) A critical role of lateral hypothalamus in context-induced relapse to alcohol seeking after punishment-imposed abstinence J Neurosci 34(22), 7447-7457 IF: 6.167
26. Kumakura Y, Gjedde A, Caprioli D, Kienast T, Beck A, Plotkin M, Schlagenhauf F, Vernaleken I, Grunder G., Bartenstein P, Heinz A, Cumming P (2013) Increased turnover of dopamine in caudate nucleus of detoxified alcoholic patients PLoS One 8(9):e73903 IF: 3.752
27. Caprioli D, Sawiak SJ, Merlo E, Theobald DE, Spoelder M, Jupp B, Voon V, Carpenter TA, Everitt BJ, Robbins TW, Dalley JW (2014) Gamma aminobutyric acidergic and neuronal structural markers in the nucleus accumbens core underlie trait-like impulsive behavior Biol Psychiatry 75(2), 115-123 IF: 13.382
28. Virdee K, McArthur S, Brischoux F, Caprioli D, Ungless MA, Robbins TW, Dalley JW, Gillies GE (2014) Antenatal glucocorticoid treatment induces adaptations in adult midbrain dopamine neurons, which underpin sexually dimorphic behavioral resilience Neuropsychopharmacology 39(2), 339-350 IF: 8.294
29. Voon V, Irvine MA, Derbyshire K, Worbe Y, Lange I, Abbott S, Morein-Zamir S, Dudley R, Caprioli D, Harrison NA, Wood J, Dalley JW, Bullmore ET, Grant JE, Robbins TW (2014) Measuring "waiting" impulsivity in substance addictions and binge eating disorder in a novel analogue of rodent serial reaction time task Biol Psychiatry 75(2), 148-155 IF: 13.382
30. Moreno M, Economidou D, Mar AC, Lopez-Granero C, Caprioli D, Theobald DE, Fernando A, Newman AH, Robbins TW, Dalley JW (2013) Divergent effects of D(2)/(3) receptor activation in the nucleus accumbens core and shell on impulsivity and locomotor activity in high and low impulsive rats. Psychopharmacology (Berl) 228(1), 19-30 IF: 4.415
31. Caprioli D, Hong, YT, Sawiak SJ, Ferrari V, Williamson DJ, Jupp B, Carpenter AT, Aigbirhio FI, Everitt BJ, Robbins TW, Fryer, TD, Dalley JW (2013) Baseline-dependent effects of cocaine pre-exposure on impulsivity and D2/3 receptor availability in the rat striatum: possible relevance to the attention-deficit hyperactivity syndrome Neuropsychopharmacology 38(8), 1460-1471 IF: 8.294
32. Jupp B, Caprioli D, Saigal N, Reverte I, Shrestha S, Cumming P, Everitt BJ, Robbins TW, Dalley JW (2013) Dopaminergic and GABA-ergic markers of impulsivity in rats: evidence for anatomical localisation in ventral striatum and prefrontal cortex Eur J Neurosci 37(9), 1519-1528 IF: 3.386
33. Riss PJ, Hong YT, Marton J, Caprioli D, Williamson DJ, Ferrari V, Saigal N, Roth BL, Henriksen G, Fryer TD, Dalley JW, Aigbirhio FI (2013) Synthesis and evaluation of 18F-FE-PEO in rodents: an 18F-labeled full agonist for opioid receptor imaging J Nucl Med 54(2), 299-305 IF: 10.057
34. Fernando AB, Economidou D, Theobald DE, Zou MF, Newman AH, Spoelder M, Caprioli D, Moreno M, Hipolito L, Aspinall AT, Robbins TW, Dalley JW (2012) Modulation of high impulsivity and attentional performance in rats by selective direct and indirect dopaminergic and noradrenergic receptor agonists Psychopharmacology (Berl) 219(2), 341-352 IF: 4.415
35. Riss PJ, Hong YT, Williamson D, Caprioli D, Sitnikov S, Ferrari V, Sawiak SJ, Baron JC, Dalley JW, Fryer TD, Aigbirhio FI (2011) Validation and quantification of [18F]altanserin binding in the rat brain using blood input and reference tissue modeling J Cereb Blood Flow Metab 31(12), 2334-2342 IF: 6.96
36. Molander AC, Mar A, Norbury A, Steventon S, Moreno M, Caprioli D, Theobald DE, Belin D, Everitt BJ, Robbins TW, Dalley JW (2011) High impulsivity predicting vulnerability to cocaine addiction in rats: some relationship with novelty preference but not novelty reactivity, anxiety or stress. Psychopharmacology (Berl) 215(4), 721-731 IF: 4.415
37. Bari A, Theobald DE, Caprioli D, Mar AC, Aidoo-Micah A, Dalley JW, Robbins TW (2010) Serotonin modulates sensitivity to reward and negative feedback in a probabilistic reversal learning task in rats Neuropsychopharmacology 35(6), 1290-1301 IF: 8.294
38. Caprioli D, Celentano M, Dubla A, Lucantonio F, Nencini P, Badiani A (2009) Ambience and drug choice: cocaine- and heroin-taking as a function of environmental context in humans and rats Biol Psychiatry 65(10), 893-899 IF: 13.382
39. Celentano M, Caprioli D, Dipasquale P, Cardillo V, Nencini P, Gaetani S, Badiani A (2009) Drug context differently regulates cocaine versus heroin self-administration and cocaine- versus heroin-induced Fos mRNA expression in the rat Psychopharmacology (Berl) 204(2), 349-360 IF: 4.415
40. Caprioli D, Celentano M, Paolone G, Lucantonio F, Bari A, Nencini P, Badiani A (2008) Opposite environmental regulation of heroin and amphetamine self-administration in the rat Psychopharmacology (Berl) 198(3), 395-404 IF: 4.415
41. Paolone G, Conversi D, Caprioli D, Bianco, PD, Nencini P, Cabib S, Badiani A (2007) Modulatory effect of environmental context and drug history on heroin-induced psychomotor activity and fos protein expression in the rat brain Neuropsychopharmacology 32(12), 2611-2623 IF: 8.294
42. Caprioli D, Paolone G, Celentano M, Testa A, Nencini P, Badiani A (2007) Environmental modulation of cocaine self-administration in the rat Psychopharmacology (Berl) 192(3), 397-406 IF: 4.415
43. Scaccianoce S, Del Bianco P, Paolone G, Caprioli D, Modafferi AM, Nencini P, Badiani A (2006) Social isolation selectively reduces hippocampal brain-derived neurotrophic factor without altering plasma corticosterone Behav Brain Res 168(2), 323-325 IF: 3.332
44. Antonilli L, Petecchia E, Caprioli D, Badiani A, Nencini P (2005) Effect of repeated administrations of heroin, naltrexone, methadone, and alcohol on morphine glucuronidation in the rat Psychopharmacology (Berl) 182(1), 58-64 IF: 4.415


Review Articles
1. Milella MS, D’Ottavio G, De Pirro S, Barra M, Caprioli D, Badiani A (2023) Heroin and its metabolites: relevance to heroin use disorder. Transl Psychiatry 13(1): 120 IF: 7.989
2. Venniro M, Marino RAM, Chow JJ, Caprioli D, Epstein DH, Ramsey LA, Shaham Y (2022) The Protective Effect of Social Reward on Opioid and Psychostimulant Reward and Relapse: Behavior, Pharmacology, and Brain Regions J Neurosci 42(50), 9298-9314 IF: 6.167
3. Vincenzi M, Milella MS, D’Ottavio G, Caprioli D, Reverte I, Maftei D (2021) Targeting Chemokines and Chemokine GPCRs to Enhance Strong Opioid Efficacy in Neuropathic Pain Life 12(3), 398 IF: 3.251
4. Venniro M, Reverte I, Milella MS, Li X, Grimm JW, Caprioli D (2021) Factors modulating the incubation of drug craving and their clinical implications Neuroscience Beobheavioral Review 131, 847-864 IF: 8.989
5. Badiani A, Caprioli D, De Pirro S (2019) Opposite environmental gating of the experienced utility ('liking') and decision utility ('wanting') of heroin versus cocaine in animals and humans: implications for computational neuroscience. Psychopharmacology 236(8), 2451-2471 IF: 4.415
6. Venniro M, Caprioli D, Shaham Y (2019) Novel models of drug relapse and craving after voluntary abstinence Neuropsychopharmacology 44(1), 234-235 IF: 8.294
7. Caprioli D, Justinova Z, Venniro M, Shaham Y (2018) Effect of novel allosteric modulators of metabotropic glutamate receptors on drug self-administration and relapse: a review of preclinical studies and their clinical implications Biol Psychiatry 84(3), 180-192 IF: 13.382
8. Venniro M, Caprioli D & Shaham Y (2015) Animal models of drug relapse and craving: from drug priming-induced reinstatement to incubation of craving after voluntary abstinence Progress in Brain Research Vol. 224:25-52 IF: 2.453
9. Li X, Caprioli, D & Marchant NJ (2014) Recent updates on incubation of drug craving: a mini-review Addict Biol 20(5), 872-6 IF: 4.093
10. Hayes DJ, Jupp B, Sawiak SJ, Merlo E, Caprioli D & Dalley JW (2014) Brain gamma-aminobutyric acid: a neglected role in impulsivity Eur J Neurosci 39(11), 1921-1932 IF: 3.386
11. Lucantonio F, Caprioli D & Schoenbaum G (2014) Transition from 'model-based' to 'model-free' behavioral control in addiction: Involvement of the orbitofrontal cortex and dorsolateral striatum Neuropharmacology 76 Pt B, 407-415 IF: 5.273
12. Caprioli D, Fryer TD, Sawiak SJ, Aigbirhio FI, Dalley JW (2013) Translating positron emission tomography studies in animals to stimulant addiction: promises and pitfalls Curr Opin Neurobiol 23(4), 597-606 IF: 6.627
13. Jupp B, Caprioli D & Dalley JW (2013) Highly impulsive rats: modelling an endophenotype to determine the neurobiological, genetic and environmental mechanisms of addiction Dis Model Mech 6(2), 302-311 IF: 5.723
14. McNabb CB, Russell BR, Caprioli D, Nutt DJ, Gibbons S, Dalley JW (2012) Single chemical entity legal highs: assessing the risk for long term harm Curr Drug Abuse Rev 5(4), 304-319 IF: 1.429
15. Virdee K., Cumming P, Caprioli D, Jupp B, Rominger A, Aigbirhio FI, Fryer TD, Riss PJ, Dalley JW (2012) Applications of positron emission tomography in animal models of neurological and neuropsychiatric disorders Neurosci Biobehav Rev 36(4), 1188-1216 IF: 8.989
16. Cumming P, Caprioli D & Dalley JW (2011) What have positron emission tomography and 'Zippy' told us about the neuropharmacology of drug addiction? British Journal of Pharmacology 163(8), 1586-1604 IF: 9.473
17. Caprioli D, Celentano M, Paolone G, Badiani A (2007) Modeling the role of environment in addiction. Prog Neuropsychopharmacol Biol Psychiatry 31(8), 1639-1653 IF: 5.201

Invited Commentaries, book chapters and editorials
1. de Guglielmo G, Kallupi M, Cippitelli A, Caprioli D, Lutfy K (2023) Editorial: Opioids and opioid-use disorders Front Pharmacol 14:1227174 IF: 5.6
2. Reverte I, D'Ottavio G, Milella MS, Caprioli D (2022) Sex differences in the immune system: Implications for cocaine relapse. Brain Behav Immun doi: 10.1016/j.bbi.2022.05.009 IF: 19.227
3. Caprioli D, Calu D, Shaham Y (2014) Loss of phasic dopamine: a new addiction marker? Nat Neurosci, 17(5), 644-646 IF: 24.884
4. Badiani A, Caprioli D, Testa A, De Luca MT, Celentano M (2011) Environmental modulation of drug taking
In: Animal Models of Drug Addiction (Mary C Olmstead, ed), Humana Press, Vol. 53, pp 293-309

Invited Lectures
1. August 2023 (Chair) ‘Pharmacokinetic and pharmacodynamic determinants of opioid use disorder (OUD) and their clinical implications’ EBPS 2023, Mannheim, D
2. July 2023 ‘Pharmacokinetic and pharmacodynamic relationships as they pertain to illicit opioid use and treatment of opioid use disorder in humans’ Universitätsklinikum Erlangen, D
3. September 2022 (Chair) ‘Evidence for Heroin-induced social isolation in the rats’ International Drug Abuse Research Society, Nice, FR
4. September 2022 ‘The Impact of continuously high versus intermittently high brain levels of heroin on incubation of craving’ International Drug Abuse Research Society, Nice, FR
5. November 2021 ‘Animal models of drug relapse: from drug priming-induced reinstatement after extinction to relapse after social-based voluntary abstinence’ The neurobiology of drug addiction and drug abuse meeting, University of Marseille, FR
6. October 2021 (Chair) ‘The cellular mechanisms of the anti-craving effects of social interaction’ International meeting on metabotropic glutamate receptor 2021, Taormina, IT
7. September 2021 ‘The cellular mechanisms of the anti-craving effects of social interaction’ Addiction 2021, Villasimius, IT -CANCELLED due to Covid-19-
8. July 2021 (Chair) ‘The pharmacokinetics determinant of substance use disorder’ EBPS 2021, Maastricht, NL
9. March 2018 ‘Modeling drug relapse’ University of Bordeaux, Bordeaux, FR
10. November 2017 ‘The Neurobiology of Abnormal Decision-Making Processes: Focus on Insula and Drug Craving’ Fondazione Santa Lucia, Rome, IT
11. October 2016 ‘Neural mechanisms underlying the incubation of methamphetamine craving after voluntary abstinence’ University of Sussex, Brighton, UK
12. Sep 2016 ‘Neural mechanisms underlying the incubation of methamphetamine craving after voluntary abstinence’ University of Bordeaux, Bordeaux, FR
13. Jul 2016 ‘Effect of the novel positive allosteric modulator of mGluR2 AZD8529 on incubation of methamphetamine craving after prolonged voluntary abstinence’, New Targets and Medication meeting, NIDA, Bethesda, USA
14. December 2015 ‘Neural mechanisms underlying the incubation of methamphetamine craving after voluntary abstinence’ NIAAA lecture seminar series, Bethesda, USA
15. October 2015 ‘Neural mechanisms of incubation of methamphetamine craving after prolonged voluntary abstinence’ SfN meeting in Chicago, USA
16. Septemeber 2015 ‘Effect of the novel positive allosteric modulator of mGluR2 AZD8529 on incubation of methamphetamine craving after prolonged voluntary abstinence’ Joint EBPS – EBBS meeting in Verona, Italy
17. Dec 2014 ‘Choice of palatable food versus drugs of abuse in the laboratory rat: implications for contingency management treatment in humans’ Seminar series at NIDA IRP, Baltimore, MD
18. July 2014 ‘Incubation of methamphetamine craving after prolonged self-imposed abstinence in a contingency management alternative-reward procedure’ Branch meeting of Markus Heilig, Clinical director of NIAAA/NIDA, Bethesda, MD
19. June 2012 ‘Translating positron emission tomography studies in animals to stimulant addiction: promises and pitfalls’ Discussion Group Semiar series, Director Trevor W. Robbins, University of Cambridge
20. Sept 2009 ‘Ambience and drug choice: cocaine- and heroin-taking as a function of environmental context in humans and rats’ Discussion Group Semiar series, Director Trevor W. Robbins, University of Cambridge
21. June 2005 ‘Environmental modulation of the psychomotor activating effects’ Italian Society of Pharmacology, 32° meeting, Naples, IT