Phd in PHARMACEUTICAL SCIENCES

email: daniela.secci@uniroma1.it
phone: 0649913763
building: CU019
room: 103

Director Department of Chemistry and Technologies of Drugs
Full Professor of Pharmaceutical and Toxicological Chemistry (Analysis III) and Pharmaceutical Biotechnologies at Pharmacy and Medicine Faculty of Sapienza University of Rome.
She is member since A.A. 2014-2015 of the College of Pharmacy in PhD Pharmaceutical Sciences.
She is the referent person, with rectoral delegation, for the Faculty of Pharmacy and Medicine - Chemistry Section Pharmaceutics of pre- and post-graduate internship activities.

Educational Activity:
University of Cagliari:
- 1990-91, 1991-92, 1992-93 e 1993-94 Practical lessons of “Esercitazioni di Chimica Farmaceutica e Tossicologica 1°” and of “Analisi dei Medicinali I” -
- 1994-95 e 1995-96 in charge of “Analisi dei Farmaci I”.
- 1990 al 1996 tutor in the course of “Preparazione Estrattiva e Sintetica dei Farmaci” –
University of Rome “La Sapienza”
- 2001 - 2004, practical lessons of “Analisi dei Medicinali”
- 2002-2003 e 2003-2004 in charge of “Analisi Chimico Farmaceutica e Tossicologica”
- 2004-2005 in charge of “Analisi Chimico Farmaceutica e Tossicologica 1
- 2005-2015 professor of “Analisi Chimico Farmaceutica e Tossicologica I
- 2015-2021 professor of “Analisi Chimico Farmaceutica e Tossicologica III
- 2019 professor of Pharmaceutical Biotechnology

She is s co-author of more than 145 publications and 3 patents.

The scientific activity concerns:

1. Studies of synthesis and reaction mechanism of carbon dioxide with different substrates for the formation of molecules with potential biological activity (research activity carried out during the first years of undergraduate research)
2. Studies on the mechanism and on the anionic activation of phase transfer reactions and applications to nucleophilic substitution reactions (research activity carried out in collaboration with the Department of Organic and Industrial Chemistry of the University of Milan)
3. Separation by selective stereo HPLC of biologically active chiral molecules
(research activity still carried out in collaboration with the Istituto Superiore di Sanità)
4. Design, synthesis and biological evaluation of new compounds active on Helicobacter
pylori, on Candida strains and on other antimicrobial agents (activity carried out in collaboration with the collaboration with the Department of Public Health of the University of Rome La Sapienza, with the Institute of Microbiology of the University of Milan and with the Stanley Division of Developmental Neurovirology, Johns Hopkins University School of Medicine, of Baltimore)
5. Design, synthesis and biological evaluation of new selective inhibitors on monoamine oxidases, MAO-A and MAO-B, (current line of research documented by numerous papers, carried out since 2002 to date). numerous works, carried out since 2002 to date, first, as regards the biochemical assays, with Dept. biochemical assays, with Dept. of Biochemical Sciences "A. Rossi Fanelli". University of Rome La Sapienza" University of Rome and, as far as computational studies are concerned, with the Dept. of Pharmacological Pharmacobiological Sciences, University of Catanzaro "Magna Græcia", then in collaboration with the
Department of Pharmacology, Facultad de Farmacia, University of Santiago de Compostela,
Spain and with the Pharmaceutical Chemistry and Centre of Excellence for Pharmaceutical Sciences, School of Pharmacy, North-West University, South Africa.
6. Design, synthesis and biological evaluation of novel epigenetic modulators with particular acetyltransferase inhibitors (HATs) with apoptotic and cytodifferentiating activity (current research activity in collaboration with the laboratory of Experimental Chemotherapy - Regina Elena Institute of Rome)
7. Design, synthesis and biological evaluation of new selective inhibitors of IX and XII isoforms of carbonic anhydrase.
XII isoforms of carbonic anhydrase for the treatment of cancer pathologies (current line of research in collaboration with the Department of Pharmacy, 'G. D'Annunzio' University of Chieti-
Pescara, the Department of Pharmacology of the Faculty of Pharmacy of Fatih, Istanbul,
Turkey and the Neuropharmacy Department, Section of Pharmaceutical and Nutraceutical Sciences of the University of Florence).
8. Responsible and coordinator of a Project on the development and characterization of monoclonal antibodies for therapeutic use isolated from transgenic plants currently in progress under a research project POR FESR LAZIO.
9. Responsible and coordinator of the Life 2020 Project NUCFARNA "New Classes of Neurological and Antidepressant Drugs, in oral solid form, oriented to both contract manufacturing and new AICs, new methodologies of process, supervision and control, and rapid reparameterization pilot scale - industrial".