DANIELA SAMBUCINI

PhD Graduate

PhD program:: XXXIV



Thesis title: EFFICACIA E CORRELATI EPIGENETICI DEGLI INTERVENTI PSICOLOGICI IN DIVERSI CONTESTI: TRE METANALISI CON REVISIONI SISTEMATICHE

Objective: The purpose of the work is to define and identify, through meta-analysis and systematic reviews, the most effective psychological intervention on traumatic events in the context of migration, in the context of organ transplantation and in the context of epigenetic mechanisms on the lines of bringing a more "contextual" mentality in the implementation of interventions for health and psychological well-being within the contexts of higher density of individuals. Method: All meta-analyses and systematic reviews submitted in this work adhere to the PRISMA guidelines, to Cochrane and New Castle Ottawa bias scales and GRADE assessment guidelines, and their protocols are systematized in PROSPERO. Both randomized and observational research designs are taken into consideration and are subjected to meta-analysis and systematic review according to a perspective of statistical analysis of both quantitative and qualitative type. The papers included collect from a minimum of 14 studies to a maximum of 52 studies. Results: Regarding Migrants, all treatments reported significant effects on depression, anxiety, and somatization, and the cognitive-behavioral treatment appeared to be the most effective intervention. Refugee status versus asylum seeker status appears to have a large effect on treatment effectiveness. Regarding the organ transplant setting, the main findings showed that psychosocial interventions were effective on depression and anxiety in kidney recipients and anxiety in heart recipients, mainly when administered after surgery and that dynamic therapies were the most effective in the observational studies. In addition, the results showed a lack of studies on the effectiveness of the psychosocial intervention on organ functioning. With respect to the contest of epigenetic changes, the results showed that, subjects who responded to therapy were associated with specific hypo- or hypermethylation, and that in subjects who did not respond to therapy it was associated in an opposite way. Meta-analysis showed significant hypermethylation of the MAOA gene after cognitive-behavioral symptom-focusing therapy only in participants with anxiety. Discussion and Conclusions: An analytical synthesis of the various results shows that the most investigated outcomes, in all works, were depression and anxiety and that the cognitive behavioral treatment seemed to be the intervention of choice applied and studied in most settings. This work could be a precious contribution in practice especially because it raises questions to be explored in future research. Future perspectives could focus on deepening the application of psychotherapies in asylum seekers, with regard to the migratory context; on deepening the adherence to treatment and the functionality of transplanted solid organs, for surgery contexts. It would be interesting, moreover, to examine the epigenetic effects after the application of other psychotherapies in addition to cognitive-behavioral treatments, and finally, to increase the use and application of dynamic psychotherapies in more contexts in order to verify their actual effectiveness.

Research products

11573/1657010 - 2023 - Effectiveness of the expressive writing on the psychological distress and traumatic symptoms of the migrants: A prospective study multiarm randomized controlled trial
Begotaraj, Edvaldo; Sambucini, Daniela; Ciacchella, Chiara; Pellicano, Gaia Romana; Pierro, Laura; Wamser-Nanney, Rachel; Aceto, Paola; De Paola, Catia; Caroppo, Emanuele; Lai, Carlo - 01a Articolo in rivista
paper: PSYCHOLOGICAL TRAUMA (American Psychological Association) pp. 738-747 - issn: 1942-9681 - wos: WOS:000860924800001 (0) - scopus: 2-s2.0-85140759704 (1)

11573/1607117 - 2022 - Editorial: Impact of the Coronavirus Pandemic (COVID-19) on Mood Disorders and Suicide
Ciacchella, Chiara; Campedelli, Virginia; Veneziani, Giorgio; Pellicano, Gaia Romana; Sambucini, Daniela; Lai, Carlo - 01m Editorial/Introduzione in rivista
paper: FRONTIERS IN PSYCHIATRY (Lausanne, Switzerland: Frontiers Media S.A. All Rights Reserved) pp. - - issn: 1664-0640 - wos: WOS:001027364300001 (5) - scopus: 2-s2.0-85124503580 (7)

11573/1604307 - 2022 - Epigenetic correlates of the psychological interventions outcomes: A systematic review and meta-analysis
Pellicano, Gaia Romana; Sambucini, Daniela; Ciacchella, Chiara; Arianna, Giusti; Paola, Aceto; Lai, Carlo - 01a Articolo in rivista
paper: JOURNAL OF AFFECTIVE DISORDERS REPORTS (Amsterdam: Elsevier B.V.) pp. - - issn: 2666-9153 - wos: (0) - scopus: 2-s2.0-85125605502 (3)

11573/1604304 - 2022 - Psychosocial treatment on psychological symptoms, adherence, and physiological function on transplanted patients: A systematic review and metanalysis
Sambucini, Daniela; Ciacchella, Chiara; Pellicano, Gaia Romana; Zingaretti, Giorgia; Pierro, Laura; Aceto, Paola; Lai, Carlo - 01a Articolo in rivista
paper: JOURNAL OF PSYCHOSOMATIC RESEARCH (Elsevier Science Limited:Oxford Fulfillment Center, PO Box 800, Kidlington Oxford OX5 1DX United Kingdom:011 44 1865 843000, 011 44 1865 843699, EMAIL: asianfo@elsevier.com, tcb@elsevier.co.UK, INTERNET: http://www.elsevier.com, http://www.elsevier.com/locate/shpsa/, Fax: 011 44 1865 843010) pp. - - issn: 0022-3999 - wos: WOS:000746626800002 (10) - scopus: 2-s2.0-85122641079 (11)

11573/1604366 - 2021 - Psychological traumas and cardiovascular disease: a controlled study
Ciacchella, Chiara; Gregorini, Teresa; Pellicano, Gaia Romana; Sambucini, Daniela; Lai, Carlo - 04d Abstract in atti di convegno
paper: MEDITERRANEAN JOURNAL OF CLINICAL PSYCHOLOGY (MEssina: Università degli Studi di Messina. Dipartimento di Scienze Umane e Sociali) pp. 180-181 - issn: 2282-1619 - wos: (0) - scopus: (0)
conference: XXII NATIONAL CONGRESS ITALIAN PSYCHOLOGICAL ASSOCIATION CLINICAL AND DYNAMIC SECTION LECCE -SEPTEMBER 17-19 2021 (Lecce; Italy)
book: XXII NATIONAL CONGRESS ITALIAN PSYCHOLOGICAL ASSOCIATION CLINICAL AND DYNAMIC SECTION LECCE -SEPTEMBER 17-19 2021 - SYMPOSIUM SESSION - ()

11573/1604313 - 2021 - Different electrophysiological responses to pain-related visual stimuli between fibromyalgia and chronic low back pain women. a pilot case-control study
Lai, C.; Ciacchella, C.; Pellicano, G. R.; Altavilla, D.; Sambucini, D.; Paolucci, T.; Sorgi, M. L.; Di Franco, M.; Saggini, R.; Aceto, P. - 01a Articolo in rivista
paper: CHRONIC STRESS (Thousand Oaks Calif.: Sage Publications) pp. - - issn: 2470-5470 - wos: (0) - scopus: 2-s2.0-85120571411 (3)

11573/1576210 - 2021 - Why people join pro-Ana online communities? A psychological textual analysis of eating disorder blog posts
Lai, C.; Pellicano, G. R.; Iuliano, S.; Ciacchella, C.; Sambucini, D.; Gennaro, A.; Salvatore, S. - 01a Articolo in rivista
paper: COMPUTERS IN HUMAN BEHAVIOR (Elsevier Science Limited:Oxford Fulfillment Center, PO Box 800, Kidlington Oxford OX5 1DX United Kingdom:011 44 1865 843000, 011 44 1865 843699, EMAIL: asianfo@elsevier.com, tcb@elsevier.co.UK, INTERNET: http://www.elsevier.com, http://www.elsevier.com/locate/shpsa/, Fax: 011 44 1865 843010) pp. - - issn: 0747-5632 - wos: WOS:000679966300019 (11) - scopus: 2-s2.0-85108115827 (12)

11573/1473279 - 2020 - Effectiveness of the psychological interventions on depression, anxiety and somatization in the migrants
Begotaraj, Edvaldo; De Paola, Catia; Sambucini, Daniela; Ciacchella, Chiara; Caroppo, Emanuele; Lai, Carlo - 01a Articolo in rivista
paper: RICERCHE DI PSICOLOGIA (Franco Angeli Riviste SRL:viale Monza 106, I 20127 Milan Italy:011 39 02 2895762, 011 39 02 289562, EMAIL: riviste@francoangeli.it, INTERNET: http://www.francoangeli.it, Fax: 011 39 02 2891515) pp. 259-274 - issn: 0391-6081 - wos: WOS:000532766700012 (1) - scopus: 2-s2.0-85086003817 (1)

11573/1451966 - 2020 - Lie for me: How empathy, alexithymia and emotional intelligence influence the ability to conform facial expression to a prosocial untrue verbal message
Pellicano, G. R.; Pierro, L.; Altavilla, D.; Massaro, G.; Marcellino, E.; Sambucini, D.; Pescegoffi, A.; Capone, M. A.; Lai, C. - 01a Articolo in rivista
paper: RASSEGNA DI PSICOLOGIA (-Roma: Nuova cultura -Rome Italy: Carocci Editore) pp. 47-58 - issn: 1125-5196 - wos: (0) - scopus: 2-s2.0-85091538283 (1)

11573/1473207 - 2020 - Efficacy of Psychological Interventions on Depression Anxiety and Somatization in Migrants: A Meta-analysis
Sambucini, D.; Aceto, P.; Begotaraj, E.; Lai, C. - 01a Articolo in rivista
paper: JOURNAL OF IMMIGRANT AND MINORITY HEALTH (New York, NY : Springer, c 2006-) pp. 1320-1346 - issn: 1557-1912 - wos: WOS:000552265200002 (11) - scopus: 2-s2.0-85088561559 (14)

11573/1635404 - 2020 - Efficacy of psychological intervention on depression, anxiety and somatization in migrants: a meta-analysis
Sambucini, D.; Begotaraj, E.; Pellicano, G. R.; Ciacchella, C.; Aceto, P.; Pierro, L.; Lai, C. - 04f Poster
conference: In XXII National Congress Italian Association of Clinical and Dynamic Psychology (Lecce)
book: In XXII National Congress Italian Association of Clinical and Dynamic Psychology - ()

11573/1604316 - 2020 - Multilevel clinical psychological intervention after the earthquake in Norcia community: a pilot study
Sambucini, D.; Pellicano, G. R.; Ciacchella, C.; Begotaraj, E.; Pierro, L.; Cinotti, F.; D'orazio, E.; Lai, C. - 01a Articolo in rivista
paper: PSYCHOLOGY HUB (Roma: Sapienza Università editrice) pp. 43-54 - issn: 2723-973X - wos: (0) - scopus: 2-s2.0-85104434812 (1)

11573/1343903 - 2019 - AN INVESTIGATION ON THE PSYCHOLOGICAL VULNERABILITY OF MIGRANTS
Begotaraj, Edvaldo; Caroppo, Emanuele; Ciacchella, Chiara; De Paola, Catia; Lai, Carlo; Sambucini, Daniela - 04f Poster
conference: AIP (Milano)
book: AIP - ()

11573/1339248 - 2019 - Metacognitive style, attachment dimension and risk for alcohol abuse in Italian adolescents
Lai, Carlo; Pierro, Laura; Begotaraj, Edvaldo; Alessia, Marani; Sambucini, Daniela; Pellicano, Gaia Romana - 01a Articolo in rivista
paper: RASSEGNA DI PSICOLOGIA (-Roma: Nuova cultura -Rome Italy: Carocci Editore) pp. 39-53 - issn: 1125-5196 - wos: (0) - scopus: 2-s2.0-85067246049 (0)

11573/1343906 - 2019 - EFFECTIVENESS OF A PSYCHOLOGICAL INTERVENTION FOCUSED ON EXPRESSIVE WRITING IN KIDNEY TRANSPLANTED PATIENTS
Pierro, Laura; Pellicano, Gaia Romana; Sambucini, Daniela; Begotaraj, Edvaldo; Lai, Carlo - 04d Abstract in atti di convegno
conference: AIP (Milano)
book: AIP - ()

11573/1341000 - 2008 - Extreme trauma and memory: The auto-biographical memory and its impairment following traumatic experiences
Germani, M.; Sambucini, D.; Mosca, L. - 01a Articolo in rivista
paper: MINERVA PSICHIATRICA (Edizioni Minerva Medica:Corso Bramante 83-85, 10126 Turin Italy:011 39 011 678282318, EMAIL: journals.dept@minervamedica.it, INTERNET: http://www.minervamedica.it, Fax: 011 39 011 674502) pp. 235-246 - issn: 0391-1772 - wos: (0) - scopus: 2-s2.0-55749088964 (0)

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