DAISY PROIETTI

Dottoressa

ciclo: XXXIII


tutor: Luca Madaro

Titolo della tesi: “MOLECULAR AND CELLULAR NETWORKS DRIVING NEUROGENIC MUSCLE ATROPHY”

During neurogenic muscle atrophy, the interruption of transmission of neurogenic signals to muscles, caused by loss of neuromuscular junction (NMJ) integrity, leads to muscle atrophy, an event that causes loss of muscle functionality with the obvious deleterious outcomes. NMJs degeneration is a prominent aspect of denervation, aging, and some pathological conditions, such as Amyotrophic Lateral Sclerosis (ALS). The precise molecular mechanisms and roles of muscle-resident cells, during neurogenic muscle atrophy, remain largely unknown. Evidence suggests that the effect on myofibers caused by neuron loss involves neighboring resident cells. Therefore, we analyzed the gene expression profiles at bulk and single-cell level of Itga7-expressing cells in muscle and revealed the existence of a subpopulation of muscle-resident glial cells, distinct from muscle satellite cells, that is selectively activated upon nerve injury. Upon nerve lesion, these cells expand and activate a neurotrophic program, that is turn off upon recovery of NMJ integrity. Moreover, these muscle-resident glial cells in the ALS mouse model increase during disease progression but exhibit impaired neurotrophic activity, suggesting that defective activation of glial cells could be implicated in ALS pathogenesis. Therefore, a better understanding of the cellular and molecular signaling pathways in muscle-resident cells during traumatic or pathological denervation is critical for developing better therapies against neurogenic muscle atrophy and degenerative diseases such as ALS.

Produzione scientifica

  • 11573/1121722 - 2018 - Role of miR-200c in myogenic differentiation impairment via p66Shc: implication in skeletal muscle regeneration of dystrophic mdx mice (01a Articolo in rivista)
    D'AGOSTINO, MARCO; TORCINARO, ALESSIO; MADARO, LUCA; BEJI, SARA; PROIETTI, DAISY; DE SANTA, FRANCESCA; MAGENTA, ALESSANDRA
  • 11573/1290583 - 2018 - Denervation-activated STAT3–IL-6 signalling in fibro-adipogenic progenitors promotes myofibres atrophy and fibrosis (01a Articolo in rivista)
    MADARO, LUCA; PROIETTI, DAISY
  • 11573/1290577 - 2019 - Histaminergic transmission slows progression of amyotrophic lateral sclerosis (01a Articolo in rivista)
    LATAGLIATA, EMANUELE CLAUDIO; SALVATORI, ILLARI; PROIETTI, DAISY; MADARO, LUCA; PUGLISI ALLEGRA, STEFANO; CAVALLARO, DANILO SALVATORE
  • 11573/1323383 - 2019 - Fibro–Adipogenic progenitors cross-talk in skeletal muscle: the social network (01g Articolo di rassegna (Review))
    BIFERALI, BEATRICE; PROIETTI, DAISY; MOZZETTA, CHIARA; MADARO, LUCA
  • 11573/1412450 - 2020 - Skeletal-Muscle metabolic reprogramming in ALS-SOD1G93A mice predates disease onset and Is a promising therapeutic target (01a Articolo in rivista)
    SALVATORI, ILLARI; PROIETTI, DAISY; HEIL, CONSTANTIN; BATTISTINI, SIMONE; MADARO, LUCA; COCCURELLO, ROBERTO
  • 11573/1496397 - 2021 - Molecular and cellular networks driving neurogenic muscle atrophy (07a Tesi di Dottorato)
    PROIETTI, DAISY
  • 11573/1212263 - 2018 - Do neurogenic and cancer-induced muscle atrophy follow common or divergent paths? (01a Articolo in rivista)
    BOUCHE', MARINA; LOZANOSKA OCHSER, BILIANA; PROIETTI, DAISY; MADARO, LUCA
  • 11573/1551537 - 2021 - Activation of skeletal muscle-resident glial cells upon nerve injury (01a Articolo in rivista)
    PROIETTI, DAISY; D'ERCOLE, CHIARA; LOZANOSKA OCHSER, BILIANA; BOUCHE', MARINA; MADARO, LUCA
  • 11573/1662908 - 2022 - Spatially resolved transcriptomics reveals innervation-responsive functional clusters in skeletal muscle (01a Articolo in rivista)
    D'ANGELO, PAOLO; RUGGIERI, VERONICA; PROIETTI, DAISY; SANCHEZ RIERA, CARLES; RENZINI, ALESSANDRA; MACONE, ALBERTO; MARZULLO, MARTA; CIAPPONI, LAURA; BONVISSUTO, DAVIDE; GIORDANI, LORENZO; MADARO, LUCA

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