Phd in MOLECULAR MEDICINE

Research: Anti-BCL-2 drugs in the treatment of Notch-dependent T-cell Acute Lymphoblastic Leukemia

PERSONAL INFORMATION

Name and surname: CLAUDIA VARRICCHIO
Address: Via Polesine 20, 00161, Rome
Telephone: 3452167374
E-mail: claudia.varricchio@uniroma1.itn
Nationality: Italian
Date of birth: 14/11/1997

EDUCATION AND TRAINING:
13/11/2023: Seminar Activity at Master’s Degree in Medicine and Surgery
(F course, LM-41), University of Rome, La Sapienza; Title: “CRISPR/CAS9 – A revolutionary tool for gene editing”,

14/11/2022: Seminar Activity at Master’s Degree in Medicine and Surgery
(F course, LM-41), University of Rome, La Sapienza; Title: “CRISPR/CAS9 – A revolutionary tool for gene editing”,

November 2022 -February 2023: Training course in “Preclinical Testing
and Animal Welfare, Sapienza University of Rome;

1/11/22- on going: PhD in Molecular Medicine
University of Rome, La Sapienza, piazzale Aldo Moro 5, 00185, Rome.

4/10/2021-19/10/22: Experimental Thesis
Department of Experimental Medicine, Viale Regina Elena 291, 00161, Rome.
Thesis in : “Notch3 modulates mir139-5p in thymocytes selection
immature for progression of acute lymphoblastic leukemia a
T cells (T-ALL)”.

1/10/2020-19/10/2022: Master's Degree in Genetics and Molecular Biology
University of Rome, La Sapienza - Department of Biology
and Biotechnology "Charles Darwin"
Date of graduation: 10/19/2022
1/10/2020-19/10/2022: Master's Degree in Genetics and Molecular Biology
University of Rome, La Sapienza - Department of Biology
and Biotechnology "Charles Darwin"
Date of graduation: 19/10/2022
Final grade: 110/110 cum laude.

2017-2019 Bachelor's degree in Biological Sciences (L-13)
- Address: bio-sanitary
University of Molise (CB) - Department of Biosciences and Territory;
Thesis title: "Correlation between the expression levels of heme oxygenase1 and the markers of innate/acquired immunity in
human liver transplant".
Date of graduation: 11/12/2019
Final grade: 110/110 cum laude.

15/11/2018 - 14/12/2018: Curricular Internship
Company: A.S.R.E.M Isernia analysis laboratory - Ferdinando Veneziale Hospital, Isernia.
Duration in hours: 80
Employer: Dr. Carla Pepe

2011-2016: Five-year Diploma
Liceo Classico "Pietro Giannone" - Piazza Risorgimento, 4, 82100 Benevento (BN).

PARTICIPATION

11/13/2023: FlowJoTM Software v10 Training University of Rome La Sapienza, Room 101, First floor, Building D, Viale Regina Elena 295 – Serena di Cecilia;

10/12/2023 - 10/14/2023: Congress: 1st Epigenetics Society (ES) International Meeting: Epigenetics of Disease and Development; Location: Rome.
POSTER entitled: The role of the microRNAs in CXCR4-dependent maturation of thymocytes in a Notch3-induced Acute Lymphoblastic Leukemia model.

09/22/2023 - 09/23/2023 SIPMeT 2022 Congress - General pathology: the trunk of the tree of medicine, - Location: Parma;
POSTER entitled: Hyperactive Notch3 derails CXCR4-dependent maturation of DN thymocytes to sustain T-cell Acute Lymphoblastic Leukemia progression.

PERSONAL SKILLS AND COMPETENCES:
- Statistical skills with SPSS and ANOVA.
- Bioinformatics skills (Pymol).
- Knowledge and experience with RNA/DNA extraction and protein extraction.
- PCR and qPCR analysis.
- Experience in cell cultures.
- Experience in basic molecular biology techniques.
- Experience in functional genomics (miRNA).
- Western blot technique.
- Transfection technique (Neon system Transfection).
- Flow cytometry analysis.
- Processing of organs and tissues from mouse models
genetically modified.
- Pharmacological treatments.

Native language: ITALIAN

Other languages: ENGLISH
- reading ability: B1
- writing ability: B1
- oral expression skills: B1

IT SKILLS
- In-depth knowledge of platforms Windows, OsX.
- Excellent knowledge of the Office package and skills in databases regarding the design, implementation and archiving.
- Excellent knowledge of mail services and the most common browsers.
- Skilled in using Pymol program for protein structure visualization.