Phd in MORPHOGENESIS AND TISSUE ENGINEERING

email: claudia.giampietri@uniroma1.it
phone:

CLAUDIA GIAMPIETRI
Curriculum Vitae
Roma, February2024

Part I – General Information

Full Name Claudia Giampietri
Citizenship Italian
E-mail claudia.giampietri@uniroma1.it
Spoken Languages Italian, English

Part II – Education

Type Year Institution Notes (Degree,..Experience,…)
University 1991 Cambridge University First Certificate in English (A)
Universitygraduation 1996 Sapienza University Degree in “Scienze Biologiche”
Post-graduate studies 1996-99 IDI-IRCCS, Rome Fellowships in vascularbiology
Visiting scientist 1999 ThomasJefferson University Prof E.AlnemriLaboratory
Middle school Professorship 2001 MIUR Science teacher in middle schools
PhD 2003 Sapienza University, Rome “Scienze e Tecnologie Cellulari”
“Assegni di ricerca” 2004-09; 2012-14 Sapienza University, Rome Supervisor Prof. E. Ziparo
Post-doc fellowship 2009-11 Sapienza University, Rome Supervisor Prof. E. Ziparo
High school Professorship 2013 MIUR Science teacher in high schools
National ScientificQualification 2014 MIUR Human AnatomyAssociate Professor




Part III – Appointments

IIIA – Academic Appointments

Start End Institution Position
2016 2019 Sapienza University, Rome RTD-B Bio/16
2017 on Sapienza University, Rome Member of Academic Board,PhD program in Morphogenesis Tissue Engineering
2019 on Sapienza University, Rome Human Anatomy Associate Professor
2019 on Sapienza University, Rome RAM (academic manager of international mobility in the pharmaceutical area)
2020 on Ministero dell’Università e della Ricerca “REPRISE” scientific expert




IIIB – Other Appointments

Start End Institution Position
2001 2013 MIUR Science teacher in middle schools
2013 2016 MIUR Science teacher in high schools

Part IV – Teaching experience


2009 2017 Sapienza University, Rome Teaching of HistologyatC.d.L Logopedia “A” in Professioni Sanitarie della Riabilitazione della Facoltà di Medicina e Odontoiatria; HistologyatC.d.L. in Tecniche Audiometriche della Facoltà di Medicina e Odontoiatria
2015 on Sapienza University, Rome Teaching of Human AnatomyatCorso di Laurea delle Professioni Sanitarie in Tecniche di Fisiopatologia Cardiocircolatoria e Perfusione Cardiovascolare - Facoltà di Medicina e Odontoiatria
2017 on Sapienza University, Rome Teaching of Human AnatomyatCorso di Laurea in Dietistica- Facoltà di Farmacia e Medicina, Medicina e Odontoiatria
2017 on Sapienza University, Rome Teaching ofHuman AnatomyatCorso di Laurea in Scienze Farmaceutiche Applicate, Facoltà di Farmacia e Medicina
2017 on Sapienza University, Rome Teaching of Human AnatomyatCorso di Laurea in Tecniche della prevenzione nell'ambiente e nei luoghi di lavoro (abilitante alla professione sanitaria di Tecnico della prevenzione nell'ambiente e nei luoghi di lavoro)-Facoltà di Medicina e Odontoiatria-polo di Rieti
2021 on Sapienza University, Rome Teaching of Human Anatomyat Corso di Laurea in Assistenza Sanitaria-Facoltà di Medicina e Odontoiatria
2023 on Sapienza University, Rome Teaching of Human Anatomyat Corso di Laurea in Tecniche Audioprotesiche-Facoltà di Medicina e Odontoiatria, Farmacia e Medicina
2009 on Sapienza University, Rome Member of examcommissions in the following Corsi di laurea: Logopedia “A” and Tecniche Audiometriche (Histologyexams); Tecniche di Fisiopatologia Cardiocircolatoria e Perfusione Cardiovascolare, Dietistica, Scienze Farmaceutiche Applicate, Infermieristica A, Tecniche della prevenzione nell'ambiente e nei luoghi di lavoro, Tecniche di Laboratorio Biomedico, Biotecnologie, Ingegneria Clinica, Medicina e Chirurgia A, Medicina e Chirurgia C(Human Anatomyexams)


Part V - Society and association
memberberships, Awards and Honors

Year Title
1999-on Member of Italian National Board of Biologists
1998 Nato short fellowship for international conference attendance
2021 Member of Società Italiana di Anatomia e Istologia
2022 Member of Società Italiana di Istochimica
2023 Member of Collegio dei Docenti di Anatomia Umana
2023 Editor for “Cells” (international, peer-reviewed, open access journal IF 7.677)

2023 Erasmus Teaching Mobility and Training at KATHOLIEKE UNIVERSITEIT LEUVEN


Part VI - Funding Information [grants as PI-principal investigator]

Year Title Founding body Grant value
2017 FFABR grant (PI) MIUR 3000 euros
2018 “c-Flip role in cell death, survival and autophagy crosstalk” grant (PI) Italian-India cooperation grant, Sapienza 7500 euros
2022 Meccanismi di controllo autofagico nella progressione tumorale del colangiocarcinoma MIUR 3000 euros

Part VII – Research Activities

Keywords Brief Description

apoptosis The scientific activity of Dr. Giampietrifocuses on molecular mechanisms controlling cell death, proliferation and autophagy in normal and pathological conditionsboth in humans and in experimental models.More in detail these issues have been addressed in:
a) male and female gonads (particularly fetal and post-natal germ cells);
b) heart;
c) skeletal muscle stem cell compartment;
d) endothelial cells from large vessels;
e) fibroblasts;
f)human cancer cell lines (from melanoma, prostate cancer, hepatocarcinoma, cholangiocarcinoma).
g) glial cells (Schwann cells)
Dr. Giampietri has contributed to clarify different roles of the well-known anti-apoptotic cellular-Flice Like Inhibitory Protein (c-FLIP) in severalin vitro and in vivo models. Dr Giampietri has been involved in the production of a c-FLIP transgenic mouse model and she has identified novel un-expected functions of c-FLIP in autophagy modulation, endoplasmic reticulum stress response and lipid accumulation. Dr Giampietri studies have been carried out through cellular and molecular biology techniques as well as confocal immunofluorescence and immunohistochemistry.
More recently Dr Giampietri is focusing on nerve-cancer cross-talk in melanoma and cholangiocarcinoma models with a particular focus on the role played by Schwann cells.

cell death
c-FLIP
proliferation
apoptosis inhibitors
autophagy
cancer



Part VIII – Summary of Scientific Achievements



Research Articles
Impact
Factor
1)“E1A stimulates FGF-2 release promoting differentiation of primary endothelialcells”
C Giampietri, M Levrero, A Felici, A D’Alessio, MC Capogrossi, C Gaetano.
Cell Death and Differentiation (2000) 7, 292-301.

2)“Platelet-derived growth factor inhibits basic fibroblast growth factor angiogenic properties in vitro and in vivo through its alpha receptor”
F De Marchis, D Ribatti, C Giampietri, A Lentini, D Faraone, M Scoccianti, MC Capogrossi, A Facchiano.
Blood (2002) 99, 2045-2053.

3)"RGDS peptide induces caspase 8 and caspase 9 activation in human endothelialcells"
MS Aguzzi,C Giampietri, F De Marchis, F Padula, R Gaeta, G Ragone, MC Capogrossi, A Facchiano.
Blood (2004) 103(11), 4180-4187.

4) "The Fas system in the seminiferous epithelium and its possible extra-testicular role"
A Riccioli, L Salvati, A D'Alessio, D Starace, C Giampietri, P De Cesaris, A Filippini, E Ziparo.
Andrologia(2003) 35(1), 64-70. Review.

5)"Characterization of signaling pathways leading to Fas expression induced by TNF-α: pivotal role of NFκB"
D Starace, A Riccioli, A D'Alessio,C Giampietri, S Petrungaro, R Galli, A Filippini, E Ziparo, P De Cesaris.
FASEB Journal (2005) 19(3),473-5.

6)“Flip is expressed in mouse germ cells and protects from apoptosis ”
C Giampietri, S Petrungaro, P Coluccia, A D’Alessio, D Starace, A Riccioli, SM Srinivasula, E Alnemri, F Palombi, A Filippini, E Ziparo, P De Cesaris.
Cell Death and Differentiation (2003) 10(2),175-84.

7)"Germ cell apoptosis control during spermatogenesis"
C Giampietri, S Petrungaro, P Coluccia, A D'Alessio, D Starace, A Riccioli, F Padula, F Palombi, E Ziparo, A Filippini, P De Cesaris.
Contraception (2006) 72, 298-302.



8)"c-Flip expression and function in fetal mouse gonocytes".
C Giampietri, S Petrungaro, F G Klinger, P Coluccia, A Paone, E Vivarelli, A Filippini, P De Cesaris, M De Felici, E Ziparo.
FASEB Journal (2006) 20(1):124-6.

9)"c-FlipL is expressed in undifferentiated mouse male germ cells".
C Giampietri, S Petrungaro, P Coluccia, F Antonangeli, A Paone, F Padula, P De Cesaris, E Ziparo, A Filippini.
FEBS letters (2006) 580(26), 6109-14.

10)"c-Flip over-expression reduces cardiac hypertrophy in response to pressure overload"
C Giampietri, S Petrungaro, M Musumeci, P Coluccia, F Antonangeli, P De Cesaris, A Filippini, G Marano, E Ziparo.
Journal of Hypertension (2008) 26(5), 1008-16.

11)“Testis atrophy and reduced sperm motility in transgenic mice overexpressing c-FLIP(L)
F Antonangeli, S Petrungaro S, P Coluccia, Filippini A, E Ziparo,C Giampietri.
Fertility and Sterility (2010) 93(5),1407-14.

12)"Expression profile of a 400 bp Stra8 promoter region during spermatogenesis”
FAntonangeli, C Giampietri, S Petrungaro, A Filippini, E Ziparo.
Microscopy Research and Technique (2009) 72(11), 816-22.

13)"Thrombin-mediated impairment of fibroblast growth factor-2 activity”
PTotta, R De Cristofaro, C Giampietri, MS Aguzzi, D Faraone, MC Capogrossi, A Facchiano.
FEBS J. (2009) 276 (12), 3277-89.

14)“Intracellular targets of RGDS peptide in melanoma cells”
MS Aguzzi, P Fortugno, C Giampietri, G Ragone, M C Capogrossi, A Facchiano.
Mol Cancer. (2010) 22, 9-84.

15)“c-Flip overexpression affects satellite cell proliferation and promotes skeletal muscle aging”
C Giampietri, S Petrungaro, P Coluccia, F Antonangeli, K Giannakakis, T Faraggiana, A Filippini,G Cossu, E Ziparo.
Cell Death & Disease 2010 Apr 29;1:e38. doi: 10.1038/cddis.2010.17.


16)“Plasma membrane micro domains regulate TACE-dependent TNFR1 shedding in human endothelial cells.”
A D'Alessio, B Esposito, C Giampietri, E Ziparo, JS Pober, A Filippini.
J Cell Mol Med. 2011 Jun 7.

17) “RAM, an RGDS analog, exerts potent anti-melanoma effects in vitro and in vivo.”
MS Aguzzi, D D'Arcangelo, C Giampietri ,MC Capogrossi, A Facchiano.
PLoS One. 2011;6(10):e25352.

18)“Autophagy modulators sensitize prostate epithelial cancer cell lines to TNF-alpha-dependent apoptosis.”
C Giampietri, S Petrungaro, F Padula, A D'Alessio, ES Marini, A Facchiano, A Filippini, E Ziparo.
Apoptosis. 2012 Nov;17(11):1210-22.

19)“Therapeutic implications of autophagy modulation in prostate cancer.”
C Giampietri, S Petrungaro, A Facchiano, A Filippini, E Ziparo.
J Endocrinol Invest. 2012 Nov;35(10):945.

20)“BAMM: a preliminary bibliometric analysis on melanoma manuscripts.”
D D'Arcangelo*, C Giampietri *, F Facchiano, A Facchiano.
* equally contributing Authors
Pigment Cell Melanoma Res. 2013 May;26(3):415-7.

21)“Sex-related differences in death control of somatic cells.”
C Giampietri, S Petrungaro, A Filippini, E Ziparo.
J Cell Mol Med. 2013 Apr;17(4):550-1.

22)“Autophagy in prostate cancer and androgen suppression therapy.”
E Ziparo, S Petrungaro, ES Marini, D Starace, S Conti, A Facchiano, A Filippini, C Giampietri.
Int J Mol Sci. 2013 Jun 6;14(6):12090-106.

23)“Identification of serum regression signs in infantile hemangioma”.
D D'Arcangelo, EM Nicodemi, S Rossi, C Giampietri, F Facchiano, A Facchiano.
PLoS One. 2014 Mar 5;9(3):e88545.

24)“Necroptosis: molecular signalling and translational implications”.
C Giampietri, D Starace, S Petrungaro, A Filippini, E Ziparo.
Int J Cell Biol.2014;2014:490275.

25)“Cell death”.
C Giampietri , A Paone, A D'Alessio.
Int J Cell Biol. 2014;2014:864062

26)“The endogenous caspase-8 inhibitor c-FLIPL regulates ER morphology and crosstalkwith mitochondria”.
ES Marini, C Giampietri, S Petrungaro, A Filippini, L Scorrano, E Ziparo.
Cell Death & Differentiation2015 July 22(7): 1131-43

27)“c-Flip KO fibroblasts display lipid accumulation associated with endoplasmic reticulum Stress”
C Giampietri, S Petrungaro, S Conti, A Facchiano, A Filippini, E Ziparo.
BiochimBiophys Acta-Mol and Cell Biology of Lipids 2015Jul;1851(7):929-36.

28)“Cancer microenvironment and endoplasmic reticulum stress response”
C Giampietri, S Petrungaro, S Conti, A Facchiano, A Filippini, E Ziparo.
Mediators of Inflammation 2015 Epub 2015 Sept 27

29)“Guidelines for the Use and Interpretation of Assays for Monitoring Autophagy
D Klionsky, …, CGiampietri, et al.
Autophagy 2016 12(1)1-122

30)“A novel role of c-FLIP protein in regulation of ER stress response”
S Conti, S Petrungaro, ES Marini, S Masciarelli, L Tomaipitinca, A Filippini, CGiampietri, E Ziparo.
Cell Signal 2016 Sept 28 (9):1262-9

31)“Lipid storage and autophagy in melanoma cancer stem cells”
C Giampietri, S Petrungaro, M Cordella, C Tabolacci, L Tomaipitinca, A Facchiano, A Eramo, A Filippini, F Facchiano, E Ziparo.
Int J. Mol Sci 2017 Jun 15;18(6).

32)“Multifaced roles of GSK-3 in cancer and autophagy-related diseases”
R Mancinelli, G Carpino, S Petrungaro, CL Mammola, L Tomaipitinca, A Filippini, A Facchiano, E Ziparo, C Giampietri
Oxidative Medicine and Cellular Longevity 2017 December 2nd.

33) “WIPI1, BAG1, and PEX3 Autophagy-Related Genes Are Relevant Melanoma Markers
D D’Arcangelo, C Giampietri, M Muscio, F Scatozza, F Facchiano, A Facchiano
Oxidative Medicine and Cellular Longevity 2018 December 2nd.

34) “Ion Channel Expression in Human Melanoma Samples: In Silico Identification and experimental Validation of Molecular Targets”
D D'Arcangelo, F Scatozza, C Giampietri, P Marchetti, F Facchiano, A Facchiano
Cancers. 2019 Mar29;11(4).

35) “Role of autophagy in liver epithelial cells and its impact on systemic homeostasis”
L Tomaipitinca, S Mandatori, R Mancinelli, F Giulitti, S Petrungaro, V Moresi, A Facchiano, E Ziparo, E Gaudio,C Giampietri
Nutrients. 2019 Apr 11;11(4).

36) “Melanogenesis and autophagy in melanoma”
F Scatozza, D D'Arcangelo, C Giampietri, F Facchiano, A Facchiano
Melanoma Research. 2019 May 14.


37) Expression of Genes Related to Lipid Handling and the Obesity Paradox in Melanoma: Database Analysis.
Giampietri C, Tomaipitinca L, Scatozza F, Facchiano A.
JMIR Cancer. 2020 May 19;6(1):e16974. doi: 10.2196/16974

38) Altered Tregs Differentiation and Impaired Autophagy Correlate to Atherosclerotic Disease.
Mandatori S, Pacella I, Marzolla V, Mammi C, Starace D, Padula F, Vitiello L, Armani A, Savoia C, Taurino M, De Zio D, Giampietri C, Piconese S, Cecconi F, Caprio M, Filippini A.Front Immunol. 2020 Mar 13;11:350. doi: 10.3389/fimmu.2020.00350. eCollection 2020


39) The Role of Autophagy in Osteoclast Differentiation and Bone Resorption Function.
Montaseri A, Giampietri C, Rossi M, Riccioli A, Del Fattore A, Filippini A.Biomolecules. 2020 Sep 30;10(10):1398. doi: 10.3390/biom10101398


40) Nicotinamideinhibits melanoma in vitro and in vivo.
Scatozza F, Moschella F, D'Arcangelo D, Rossi S, Tabolacci C, Giampietri C, Proietti E, Facchiano F, Facchiano A. J ExpClin Cancer Res. 2020 Oct 7;39(1):211. doi: 10.1186/s13046-020-01719-3.

41) Anti-tumor effect of oleic acid in hepatocellular carcinoma cell lines via autophagy reduction.
Frontiers in Cell and Developmental Biology
Giulitti F, Petrungaro S, Mandatori S, Tomaipitinca L, de Franchis V, D'Amore A, Filippini A, Gaudio E, Ziparo E, GiampietriC
Front Cell Dev Biol. 2021 Feb 5;9:629182. doi: 10.3389/fcell.2021.629182. eCollection 2021.

42)Guidelines for the Use and Interpretation of Assays for Monitoring Autophagy (4th edition)
Klionsky D, …, GiampietriCet al.
Autophagy. 2021 Feb 8:1-382. doi: 10.1080/15548627.2020.1797280

43) c-FLIP regulates autophagy by interacting with Beclin-1 and influencing its stability.
Tomaipitinca L, Petrungaro S, D'Acunzo P, Facchiano A, Dubey A, Rizza S, Giulitti F, Gaudio E, Filippini A, Ziparo E, Cecconi F, Giampietri C.
Cell Death Dis. 2021 Jul 8;12(7):686. doi: 10.1038/s41419-021-03957-5.
PMID: 34238932 Free PMC article.

44) Protease Activated Receptor 1 and Its Ligands as Main Regulators of the Regeneration of Peripheral Nerves.
Pompili E, De Franchis V, Giampietri C, Leone S, De Santis E, Fornai F, Fumagalli L, Fabrizi C.
Biomolecules. 2021 Nov 10;11(11):1668. doi: 10.3390/biom11111668.
PMID: 34827666

45) Cytoplasmic HDAC4 regulates the membrane repair mechanism in Duchenne muscular dystrophy.
Renzini A, Marroncelli N, Cavioli G, Di Francescantonio S, Forcina L, Lambridis A, Di Giorgio E, Valente S, Mai A, Brancolini C, Giampietri C, Magenta A, De Santa F, Adamo S, Coletti D, Moresi V.
J CachexiaSarcopenia Muscle. 2022 Apr;13(2):1339-1359. doi: 10.1002/jcsm.12891. Epub 2022 Feb 15

46) Analysis of gene expression levels and their impact on survival in 31 cancer-types patients identifies novel prognostic markers and suggests unexplored immunotherapy treatment options in a wide range of malignancies.
Giampietri C, Scatozza F, Crecca E, Vigiano Benedetti V, Natali PG, Facchiano A.
J Transl Med. 2022 Oct 12;20(1):467. doi: 10.1186/s12967-022-03670-7

47) Autophagy impairment in human bile duct carcinoma cells.
Petrungaro S, de Franchis V, Filippini A, Facchiano A, Gaudio E, Giampietri C.
Front Physiol. 2023 Sep 29;14:1249264. doi: 10.3389/fphys.2023.1249264. eCollection 2023.

48) Cholangiocarcinoma Malignant Traits Are Promoted by Schwann Cells through TGFβ Signaling in a Model of Perineural Invasion.
de Franchis V, Petrungaro S, Pizzichini E, Camerini S, Casella M, Somma F, Mandolini E, Carpino G, Overi D, Cardinale V, Facchiano A , Filippini A, GaudioE , CinziaFabrizi C and Giampietri C
Cells. 2024; 13(5):366.






Total scientific production


Product type Number Data Base Start End
Papers [international] 48 Scopus 2000 2024


Total Impact factor (ISI WOS) 241.884
Medium Impact Factor 6.364
Total Citations(Scopus) 4883
Hirsch (H) index (Scopus) 22