Phd in HUMAN BIOLOGY AND MEDICAL GENETICS

email: claudia.carissimi@uniroma1.it
phone:

CARISSIMI Claudia
Department of Molecular Medicine
Università degli Studi di Roma "La Sapienza"
E-mail address: claudia.carissimi@uniroma1.it

EDUCATION AND RESEARCH EXPERIENCE
University researcher fixed-term at University of Rome "La Sapienza" (SSDBIO13)
PhD in Genetic and Molecular Biology at the University of Rome “La Sapienza”.
“Laurea” (B.S.) in Biology at the University of Rome “La Sapienza”

MAIN RESEARCH TOPICS:
-Study of the mechanisms underlying the onset and progression of intestinal fibrosis.
-The Characterization of structural and functional peculiarities of the gut microbioma in chronic inflammatory disorders (IBD) and metabolic diseases (NAFLD/NASH)
-Identification of genes involved in the pathogenesis of eosinophilic esophagitis and in response to therapy.
-The role of AGO proteins and their associated small noncoding RNA in epigenetic regulation of gene expression and genome integrity maintenance.

Teaching and mentoring experience
2007 – present. Supervisor of Master’s degree and PhD students in Biology and Biotechnology (Università “Sapienza” Roma)
2011 – present. Teaching of Genetics, Faculty of Medicine (CLM in Medicina e Chirurgia "B") Università “Sapienza” Roma.

PUBLICATIONS

laria Laudadio, Alex Bastianelli, Valerio Fulci, Claudia Carissimi, Eleonora Colantoni, Francesca Palone, Roberta Vitali, Elisa Lorefice, Salvatore Cucchiara, Anna Negroni, Laura Stronati (2022). ZNF281 Promotes Colon Fibroblast Activation in TGFß1-Induced Gut Fibrosis. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, vol. 23, ISSN: 1422-0067, doi: 10.3390/ijms231810261

Vitali, Roberta, Palone, Francesca, Armuzzi, Alessandro, Fulci, Valerio, Negroni, Anna, Carissimi, Claudia, Cucchiara, Salvatore, Stronati, Laura (2022). Proteomic analysis identifies three reliable biomarkers of intestinal inflammation in the stools of patients with Inflammatory Bowel Disease. JOURNAL OF CROHN'S AND COLITIS, ISSN: 1873-9946, doi: 10.1093/ecco-jcc/jjac110

Carissimi, Claudia, Laudadio, Ilaria, Lorefice, Elisa, Azzalin, Gianluca, De Paolis, Veronica, Fulci, Valerio (2021). Bisulfite miRNA-seq reveals widespread CpG and non-CpG 5-(hydroxy)methyl-Cytosine in human microRNAs. RNA BIOLOGY, ISSN: 1547-6286, doi: 10.1080/15476286.2021.1927423

De Paolis V., Lorefice E., Orecchini E., Carissimi C., Laudadio I., Fulci V. (2021). Epitranscriptomics: a new layer of microRNA regulation in cancer. CANCERS, vol. 13, ISSN: 2072-6694, doi: 10.3390/cancers13133372

Fulci, V, Carissimi, C, Laudadio, I (2021). COVID-19 and preparing for future ecological crises: hopes from metagenomics in facing current and future viral pandemic challenges. OMICS, vol. 25, p. 336-341, ISSN: 1536-2310, doi: 10.1089/omi.2021.0058

Putignani, Lorenza, Oliva, Salvatore, Isoldi, Sara, Del Chierico, Federica, Carissimi, Claudia, Laudadio, Ilaria, Cucchiara, Salvatore, Stronati, Laura (2021). Fecal and mucosal microbiota profiling in pediatric inflammatory bowel diseases. EUROPEAN JOURNAL OF GASTROENTEROLOGY & HEPATOLOGY, vol. Publish Ahead of Print, ISSN: 0954-691X, doi: 10.1097/MEG.0000000000002050

Valerio Fulci, Laura Stronati, Salvatore Cucchiara, Ilaria Laudadio, Claudia Carissimi (2021). Emerging roles of gut virome in pediatric diseases. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, vol. 22, ISSN: 1422-0067, doi: 10.3390/ijms22084127

Laudadio I, Cesi V, Carissimi C (2020). Metagenomics in Italy and Europe: three actionable challenges/prospects in 2020. OMICS, vol. 24, p. 122-123, ISSN: 1557-8100, doi: 10.1089/omi.2020.0006

Salvatore Oliva, Ilaria Laudadio, Valerio Fulci, ROSSETTI, DANILO, Sara Isoldi, Laura Stronati, Claudia Carissimi (2020). SERPINB12 as a possible marker of steroid dependency in children with eosinophilic esophagitis: a pilot study. DIGESTIVE AND LIVER DISEASE, vol. 52, p. 158-163, ISSN: 1590-8658, doi: 10.1016/j.dld.2019.08.018

Claudia Carissimi, Ilaria Laudadio, Francesca Palone, Valerio Fulci, Vincenzo Cesi, Cardona Francesco, Chiara Alfonsi, Salvatore Cucchiara, Sara Isoldi, Laura Stronati (2019). Functional analysis of gut microbiota and immunoinflammation in children with autism spectrum disorders. DIGESTIVE AND LIVER DISEASE, vol. 51, p. 1366-1374, ISSN: 1590-8658, doi: 10.1016/j.dld.2019.06.006

Ilaria Laudadio, Valerio Fulci, Laura Stronati, Claudia Carissimi (2019). Next generation metagenomics: methodological challenges and opportunities. OMICS, vol. 23, p. 327-333, ISSN: 1557-8100, doi: 10.1089/omi.2019.0073

Laudadio, Ilaria, Carissimi, Claudia, Fulci, Valerio (2019). How RNAi machinery enters the world of telomerase. CELL CYCLE, vol. 18, p. 1056-1067, ISSN: 1538-4101, doi: 10.1080/15384101.2019.1609834

Laudadio, Ilaria, Orso, Francesca, Azzalin, Gianluca, Calabrò, Carlo, Berardinelli, Francesco, Coluzzi, Elisa, Gioiosa, Silvia, Taverna, Daniela, Sgura, Antonella, Carissimi, Claudia, Fulci, Valerio (2019). AGO2 promotes telomerase activity and interaction between the telomerase components TERT and TERC. EMBO REPORTS, vol. 20, ISSN: 1469-3178, doi: 10.15252/embr.201845969

Salvatore Oliva, Claudia Carissimi, Ilaria Laudadio, Valerio Fulci, Danilo Rossetti, Sara Isoldi, Salvatore Cucchiara, Laura Stronati (2019). Sa1295 – Serpinb12 As a Possible Marker of Steroid Dependency in Children with Eosinophilic Esophagitis: A Pilot Study. GASTROENTEROLOGY, vol. 156, p. S-309, ISSN: 0837-0036, doi: 10.1016/S0016-5085(19)37593-6

Ilaria Laudadio, Sara Formichetti, Silvia Gioiosa, Filippos Klironomos, Nikolaus Rajewsky, GiuseppeMacino, Claudia Carissimi, Valerio Fulci (2018). Characterization of transcription termination associated-RNAs (TTSa-RNAs): new insights into their biogenesis, tailing and expression in primary tumors. INTERNATIONAL JOURNAL OF GENOMICS, vol. 2018, ISSN: 2314-4378, doi: 10.1155/2018/1243858

Ilaria Laudadio, Valerio Fulci, Francesca Palone, Laura Stronati, Salvatore Cucchiara, Claudia Carissimi (2018). Quantitative assessment of shotgun metagenomics and 16S rDNA amplicon sequencing in the study of Human Gut Microbiome. OMICS, vol. 22, p. 248-254, ISSN: 1557-8100, doi: 10.1089/omi.2018.0013

CARISSIMI, Claudia, COLOMBO, TERESA, AZZALIN, Gianluca, CIPOLLETTA, EMANUELA, LAUDADIO, ILARIA, MACINO, Giuseppe, FULCI, Valerio (2016). Comprehensive RNA dataset of AGO2 associated RNAs in Jurkat cells following miR-21 over-expression. DATA IN BRIEF, vol. 7, p. 604-606, ISSN: 2352-3409, doi: 10.1016/j.dib.2016.02.041

GIOIOSA, SILVIA, VERDUCI, LORENA, AZZALIN, Gianluca, CARISSIMI, Claudia, FULCI, Valerio, MACINO, Giuseppe (2016). Microarray dataset of Jurkat cells following miR-93 over-expression. DATA IN BRIEF, vol. 8, p. 575-8-578, ISSN: 2352-3409, doi: 10.1016/j.dib.2016.06.001

CARISSIMI, Claudia, LAUDADIO, ILARIA, CIPOLLETTA, EMANUELA, GIOIOSA, SILVIA, Mihailovich M, Bonaldi T, MACINO, Giuseppe, FULCI, Valerio (2015). ARGONAUTE2 cooperates with SWI/SNF complex to determine nucleosome occupancy at human Transcription Start Sites.. NUCLEIC ACIDS RESEARCH, vol. 43, p. 1498-1512, ISSN: 1362-4962, doi: 10.1093/nar/gku1387

Krell, J, Stebbing, J, Frampton, Ae, CARISSIMI, Claudia, Harding, V, De Giorgio, A, FULCI, Valerio, MACINO, Giuseppe, COLOMBO, TERESA, Castellano, L. (2015). The role of TP53 in miRNA loading onto AGO2 and in remodelling the miRNA-mRNA interaction network. In: Spring Meeting for Clinician Scientists in Training 2015. THE LANCET, vol. 385 Suppl 1, p. S15, ISSN: 0140-6736, ..., doi: 10.1016/S0140-6736(15)60330-0

Krell, Jonathan, Stebbing, Justin, CARISSIMI, Claudia, Dabrowska, Aleksandra, de Giorgio, Alexander, Frampton, Adam Enver, Harding, Victoria, FULCI, Valerio, MACINO, Giuseppe, Colombo, Teresa, Castellano, Leandro (2015). TP53 regulates miRNA association with AGO2 to remodel the miRNA-mRNA interaction network. GENOME RESEARCH, p. gr.191759.115-..., ISSN: 1088-9051, doi: 10.1101/gr.191759.115

VERDUCI, LORENA, AZZALIN, Gianluca, GIOIOSA, SILVIA, CARISSIMI, Claudia, LAUDADIO, ILARIA, FULCI, Valerio, MACINO, Giuseppe (2015). microRNA-181a enhances cell proliferation in Acute Lymphoblastic Leukemia by targeting EGR1. LEUKEMIA RESEARCH, ISSN: 0145-2126, doi: 10.1016/j.leukres.2015.01.010

CARISSIMI, Claudia, CARUCCI, Nicoletta, COLOMBO, TERESA, PICONESE, SILVIA, AZZALIN, Gianluca, CIPOLLETTA, EMANUELA, CITARELLA, Franca, BARNABA, Vincenzo, MACINO, Giuseppe, FULCI, Valerio (2014). miR-21 is a negative modulator of T-cell activation. BIOCHIMIE, p. ..., ISSN: 0300-9084, doi: 10.1016/j.biochi.2014.09.021

CARISSIMI, Claudia, FULCI, Valerio, NASI, SERGIO, Montalban, Enrica, Mattugini, Nicola, Ciarapica, Roberta, Provenzano, Claudia, SAVINO, MAURO, SCAGNOLI, FIORELLA, Prosperini, Gianluca, Matrone, Carmela, Calissano, Pietro (2014). MiR-21 is an Ngf-modulated MicroRNA That supports Ngf signaling and regulates neuronal degeneration in PC12 cells. NEUROMOLECULAR MEDICINE, vol. 16, p. 415-430, ISSN: 1535-1084, doi: 10.1007/s12017-014-8292-z

CURTALE G, CITARELLA, Franca, CARISSIMI, Claudia, GOLDONI M, CARUCCI N, FULCI, Valerio, FRANCESCHINI D, MELONI F, BARNABA, Vincenzo, MACINO, Giuseppe (2010). An emerging player in the adaptive immune response: microRNA-146a is a modulator of IL-2 expression and AICD in T lymphocytes. BLOOD, vol. 115 (2), p. 265-273, ISSN: 0006-4971, doi: 10.1182/blood-2009-06-225987

Curtale, G., CITARELLA, Franca, CARISSIMI, Claudia, Carucci, N., FULCI, Valerio, Franceschini, D., Meloni, F., BARNABA, Vincenzo, MACINO, Giuseppe (2010). An Emerging Player in the Adaptive Immune Response: MicroRNA-146a is a modulator of IL-2 expression and AICD in T lymphocytes. In: 44th Annual Scientific Meeting of the European Society for Clinical Investigation, Bari, Italy, 24-27 February 2010. EUROPEAN JOURNAL OF CLINICAL INVESTIGATION, vol. 40, p. 52, Wiley Online Library, ISSN: 0014-2972, Bari, Italy,, 24-27 February 2010

CARISSIMI, Claudia, FULCI, Valerio, MACINO, Giuseppe (2009). MicroRNAs: Novel regulators of immunity.. AUTOIMMUNITY REVIEWS, vol. 8(6), p. 520-524, ISSN: 1568-9972, doi: 10.1016/j.autrev.2009.01.008

GABANELLA F, BUTCHBACH ME, SAIEVA L, CARISSIMI, Claudia, BURGHES AH, PELLIZZONI L. (2007). Ribonucleoprotein Assembly Defects Correlate with Spinal Muscular Atrophy Severity and Preferentially Affect a Subset of Spliceosomal snRNPs. PLOS ONE, vol. 2(9), ISSN: 1932-6203

CARISSIMI, Claudia, SAIEVA L, BACCON J, CHIARELLA P, MAIOLICA A, SAWYER A, RAPPSILBER J, PELLIZZONI L. (2006). Gemin8 is a novel component of the survival motor neuron complex and functions in small nuclear ribonucleoprotein assembly. THE JOURNAL OF BIOLOGICAL CHEMISTRY, vol. 281(12), p. 8126-8134, ISSN: 0021-9258, doi: 10.1093/hmg/ddi390

CARISSIMI, Claudia, SAIEVA L, GABANELLA F, PELLIZZONI L. (2006). Gemin8 is required for the architecture and function of the survival motor neuron complex.. THE JOURNAL OF BIOLOGICAL CHEMISTRY, vol. 281(48), p. 37009-37016, ISSN: 0021-9258

CARISSIMI, Claudia, BACCON J, STRACCIA M, CHIARELLA P, MAIOLICA A, SAWYER A, RAPPSILBER J, PELLIZZONI L. (2005). Unrip is a component of SMN complexes active in snRNP assembly.. FEBS LETTERS, vol. 579(11), p. 2348-2354, ISSN: 0014-5793

GABANELLA F, CARISSIMI, Claudia, USIELLO A, PELLIZZONI L. (2005). The activity of the spinal muscular atrophy protein is regulated during development and cellular differentiation.. HUMAN MOLECULAR GENETICS, vol. 14(23), p. 3629-3642, ISSN: 0964-6906

CARDINALI B, CARISSIMI, Claudia, GRAVINA P, PIERANDREI AMALDI P. (2003). La protein is associated with terminal oligopyrimidine mRNAs in actively translating polysomes.. THE JOURNAL OF BIOLOGICAL CHEMISTRY, vol. 278(37), p. 35145-35151, ISSN: 0021-9258