CHIARA SETTE

PhD Student

PhD program:: XXXIX
email: chiara.sette@uniroma1.it
building: CU027
room: 301

supervisor: prof. Mario Fontana
advisor: prof. Mario Fontana

Research: Neuropathological characterization of mouse models for the study of Down syndrome

• 2010-2016 High school diploma Liceo delle scienze umane Domenico Cotugno, L'Aquila • 2016-2020 Bachelor degree in biotechnology University of L'Aquila Thesis title: Analysis of CFTR gene mutations in cystic fibrosis • 2020-2023 Master degree in pharmaceutical biotechnology Sapienza University of Rome Thesis title: Characterization of a new mouse model for the study of development of neurodegeneration in Down syndrome • November 2023- November 2026 Biochemistry PhD Department of Biochemical Sciences Alessandro Rossi Fanelli, Sapienza University of Rome

Research products

11573/1759965 - 2026 - Systemic administration of the OGT inhibitor OSMI-1 normalizes hippocampal O-GlcNAcylation and improves recognition memory, redox balance, and brain mitochondrial homeostasis in a Rett syndrome mouse model

Sette, Chiara; Urbinati, Chiara; Lanzillotta, Chiara; Prestia, Francesca; Ciafardini, Letizia; Cosentino, Livia; Pietraforte, Donatella; Quattrini, Maria Cristina; Perluigi, Marzia; Di Domenico, Fabio; De Filippis, Bianca - 01a Articolo in rivista

paper: FREE RADICAL BIOLOGY & MEDICINE (Elsevier Science Limited:Oxford Fulfillment Center, PO Box 800, Kidlington Oxford OX5 1DX United Kingdom:011 44 1865 843000, 011 44 1865 843699, EMAIL: asianfo@elsevier.com, tcb@elsevier.co.UK, INTERNET: http://www.elsevier.com, http://www.elsevier.com/locate/shpsa/, Fax: 011 44 1865 843010) pp. 1-17 - issn: 0891-5849 - wos: WOS:001655538400001 (0) - scopus: (0)

11573/1746145 - 2025 - Enhancing protein O-GlcNAcylation in down syndrome mice mitigates memory dysfunctions through the rescue of mitochondrial bioenergetics, stress responses and pathological markers

Lanzillotta, Chiara; Prestia, Francesca; Greco, Viviana; Iavarone, Federica; Cordella, Federica; Sette, Chiara; Forte, Elena; Tramutola, Antonella; Lanzillotta, Simona; Cassano, Tommaso; Di Angelantonio, Silvia; Urbani, Andrea; Barone, Eugenio; Perluigi, Marzia; Di Domenico, Fabio - 01a Articolo in rivista

paper: REDOX BIOLOGY (Amsterdam : Elsevier) pp. - - issn: 2213-2317 - wos: WOS:001548875700002 (4) - scopus: 2-s2.0-105010958402 (4)

11573/1709575 - 2024 - Shaping down syndrome brain cognitive and molecular changes due to aging using adult animals from the Ts66Yah murine model

Lanzillotta, Chiara; Baniowska, Monika Rataj; Prestia, Francesca; Sette, Chiara; Nalesso, Valérie; Perluigi, Marzia; Barone, Eugenio; Duchon, Arnaud; Tramutola, Antonella; Herault, Yann; Di Domenico, Fabio - 01a Articolo in rivista

paper: NEUROBIOLOGY OF DISEASE (Academic Press Incorporated:6277 Sea Harbor Drive:Orlando, FL 32887:(800)543-9534, (407)345-4100, EMAIL: ap@acad.com, INTERNET: http://www.idealibrary.com, Fax: (407)352-3445) pp. 1-22 - issn: 0969-9961 - wos: WOS:001239384700001 (7) - scopus: 2-s2.0-85192167129 (12)