Dottorato in BIOLOGIA UMANA E GENETICA MEDICA

email: cecilia.battistelli@uniroma1.it
telefono: +390649918236
edificio: 5 clinica Medica 2 piano Policlinico Umberto I
stanza: 217

CECILIA BATTISTELLI
Curriculum Vitae
Place: Roma
Date: 17/03/2022

Part I – General Information
Full Name Cecilia Battistelli
Citizenship Italian
Work Address Viale regina Elena 324, 00161, Roma
Phone Number +39 0649918236
E-mail cecilia.battistelli@uniroma1.it
Spoken Languages Italian (mother tongue), English, French

Part II – Education
University graduation 2007 Sapienza University of Rome Biological Sciences (Degree), full marks and honors
Thesis title: Analysis of the regulation of microRNAs biosynthesis.
Tutor: Prof. Irene Bozzoni, University of Rome "Sapienza"
University graduation 2008 Sapienza University of Rome Biology (LS: Genetics and Molecular Biology), full marks and honors
Thesis title: Mechanisms regulating p57kip2 expression during muscle differentiation: role of DNA methylation.
Tutors: Prof. Gabriella Augusti Tocco, University of Rome "Sapienza" and Prof. Rossella Maione, University of Rome "Sapienza”
Italian Biological Licensure (ESAME DI STATO) 2011 Sapienza University of Rome
PhD 2012 Sapienza University of Rome PhD in Human Biology and Genetics
Thesis title: MyoD regulates p57kip2 expression through a long-range chromatin interaction.
Tutor: Prof. Rossella Maione, University of Rome “Sapienza”

Part III – Appointments
IIIA – Academic Appointments
15/07/2021 14/07/2024 Sapienza University of Rome Ricercatore a tempo determinato (RTD) tipo B BIO13
01/05/2018 30/04/2021 Sapienza University of Rome Ricercatore a tempo determinato (RTD) tipo A BIO13
18/09/2018 18/09/2027 Abilitazione Scientifica Nazionale 05/F1 II FASCIA
1/1/2012 30/04/2018 Sapienza University of Rome Research Fellowship (PI: Prof. Marco Tripodi)


IIIB – Other Appointments
1/4/2017 31/05/2017 Pasteur Institute Italy- Cenci Bolognetti Foundation Research Fellowship (PI: Prof. Marco Tripodi)
1/1/2013 28/02/2013 Pasteur Institute Italy- Cenci Bolognetti Foundation Research Fellowship (PI: Prof. Marco Tripodi)
1/11/2011 31/12/2011 Pasteur Institute Italy- Cenci Bolognetti Foundation Research Fellowship (PI: Prof. Rossella Maione)

Part IV – Teaching experience
2018/2019 Sapienza University of Rome Medicina e Chirurgia (canale C)
Biologia e Genetica I, modulo di Biologia Cellulare (2cfu)
2018/2022 Sapienza University of Rome Tecniche di Fisiopatologia Cardio-circolatoria e Perfusione Cardiovascolare
Basi cellulari e molecolari della vita, modulo di Biologia Applicata (2cfu)
2018/2021 Sapienza University of Rome Tecniche Ortopediche
Scienze Biomediche I, modulo di Biologia (2cfu)
2019/2022 Sapienza University of Rome Ostetricia
Basi molecolari e cellulari della vita, modulo di Biologia applicata (2cfu)

Other Teaching experiences
2013-2022 Partecipation to ADE/lessons:
Laurea Magistrale “A” in Medicina e Chirurgia e del corso di Laurea Magistrale in Biotecnologie Mediche (Prof. M. Tripodi)
Corso di Laurea Magistrale a ciclo unico in Medicina e Chirurgia (Prof. R. Strippoli)
Corso di Laurea Magistrale “C” e del corso di Laurea Magistrale “F” in Medicina e Chirurgia (Prof.ssa F. Citarella)

ASN Simulation
Value Description Threshold
24 Numero articoli ultimi 5 anni 8 SECONDA FASCIA
977 Numero citazioni ultimi 10 anni 307 SECONDA FASCIA
16 H index ultimi 10 anni 8 SECONDA FASCIA
33 Numero articoli ultimi 10 anni 23 PRIMA FASCIA
977 Numero citazioni ultimi 15 anni 770 PRIMA FASCIA
16 H index ultimi 15 anni 15 PRIMA FASCIA
33 Numero articoli ultimi 10 anni 31 COMMISSARIO
977 Numero citazioni ultimi 15 anni 1163 COMMISSARIO
16 H index ultimi 15 anni 19 COMMISSARIO

Supervision of thesis
2017/2018 Sapienza University of Rome, Facoltà di farmacia e Medicina, Corso di laurea in Biotecnologie (1 student)
Thesis title: “Ruolo dello stretching meccanico nell’induzione della transizione epitelio-mesenchimale (EMT) nelle cellule peritoneali”
2019/2020 Erasmus Degree Project
Sapienza University of Rome and Universitat de Barcelona (Spain) (1 student)
Thesis title: “Exosome-mediated intercellular communication, the role of cellular RNA-binding proteins”
2020/2022 Sapienza University of Rome, Facoltà di farmacia e Medicina, Corso di laurea in Biotecnologie mediche (3 students)
Thesis title: “Studio del ruolo della modifica m6A sui microRNA espressi in cellule di epatocarcinoma”
2 ongoing thesis projects
2020/2021 Sapienza University of Rome, Facoltà di farmacia e Medicina, Corso di laurea in Farmacia (1 student)
Thesis title: “Studio degli effetti dell’inibizione della “Methyltransferase-like 3” in epatocarcinoma”.
2022 Erasmus Plus Project
Sapienza University of Rome and Istanbul Medeniyet University (2 students)

Participation to Doctorate programmes
Sept.2019/today Sapienza University of Rome PhD program in Human Biology and Medical Genetics

Supervision of national and international PhD thesis
2020 Universität des Saarlandes (Germany) Thesis title: Design and synthesis of novel ligands for serotonin (5-HT6) receptor and inhibitors of ABCB1 efflux pump
2021 Sapienza University of Rome 1 PhD Student (First year)

Part V – Society memberberships
Year Title
2015-2019 ABCD (Associazione di Biologia Cellulare e del Differenziamento)
2018-today Epigenetics Society
2013-2015 TEMTIA (The EMT International Association)
2020-today EVIta (Extracellular Vesicle Italy)

Oral Presentations
7-8/6/2021 INVITED SPEAKER III international AICC Exosome Meeting “Cell to cell delivery in cancer and therapy: a matter of carriers and messages” Virtual Event
6-8/11/2019 1st EVIta Symposium, Palermo
22-24/11/2018 ABCD Meeting: “Signal Transduction in Cancer”, Turin
23/11/2016 INVITED SPEAKER at the Bambino Gesù Children’s Hospital (Rome).
Seminar title: The Snail repressor recruits EZH2 to specific genomic sites through the enrolment of the lncRNA HOTAIR in epithelial-to-mesenchymal transition
20-23/9/2016 – XIV FISV Congress – Rome 
30/9-1/10 2016 – XVII AIBG Congress – Cagliari
17-19/9/2015 – ABCD meeting – Bologna
7/9/2015 – RNA day 2015, the multi-faceted non coding RNA landscape – Rome
24-25-26-27/9/2014 – Congress FISV 2014- Pisa
12-13/9/2013 – Conference “RNA day 2013, the centrality of non coding RNA in gene-regulation”- Roma
12-13-14/10/2012 – 9° annual meeting IIM- Acaya, Lecce.
24-25-26/5/2012 – “Frontiers in molecular biology” SIBBM congress – Palermo.
4-5-6/6/2009 – “Frontiers in molecular biology” SIBBM Congress – Napoli.

Awards and Honors
Year Title
2019 EVIta (Extracellular Vesicle Italy) award (best oral presentation)
2018 AIRC award at the AIBG (Associazione Italiana Biologia e Genetica) Congress (young investigator award)
2013 TEMTIA (The EMT International Association) award (young investigator award)
2012 IIM (Italian Institute of Myology) award (best oral presentation)
2012 SIBBM (Società Italiana Biofisica Biologia Molecolare) award (best oral presentation)
2011 EMBO award (young investigator award)
2010 Collegio Ghislieri award (young investigator award)

Editorial activity
2016-2017
2017-2018 Academic Editor “Mediators of Inflammation”
Academic Editor “Frontiers in Pharmacology”
2019-2020 Academic Editor “Frontiers in Pharmacology”
2020 Academic Editor “Biomedicine”
2020 Review Editor for the Cellular Biochemistry section of “Frontiers in Cell and Developmental Biology” and of “Frontiers in Molecular Biosciences”

Peer Review activity
Peer review activity for the following journals:
Cell death and Differentiation, Oncogene, Cancers, Sensors, Molecules, Molecular Cancer, International Journal of Molecular Sciences, Cancer Medicine, Experimental and Molecular Pathology, Cellular Physiology and Biochemistry, Clinics and Research in Hepatology and Gastroenterology, Cells, Cell communication and Signalling, International Journal of Cancer, Cell Death and Disease, Gene, Genes, Pharmaceuticals, Oxidative Medicine and Cellular longevity, Cancer Gene Therapy, Frontiers in Cell and Developmental Biology, Cancer Cell International.

Part VI – Funding Information [grants as PI-principal investigator or I-investigator]

2008 “Differenziamento miogenico e neuronale: fattori di regolazione”. (I) Ricerche UNIVERSITARIE (ex ricerche di ATENEO) codice C26A082MNW.
2009-2011 Interplay between myogenic factors and cell cycle control. (I) Istituto Pasteur – Fondazione Cenci Bolognetti
2012-2014 Transcriptional regulation through long-range chromatin interactions in muscle cells: the CDKN1C-KCNQ1 locus. (I) Istituto Pasteur – Fondazione Cenci Bolognetti
2014-2016 Dissecting HNF4and Snail functions in hepatocyte reprogramming: role in liver cancer and fibrosis (I) AIRC Investigator Grant n.IG14114
2017-2019 Developing ncRNAs-based strategies to counteract epithelial tumour progression and metastasis (I) AIRC Investigator Grant n.IG18843
2019 Molecular strategies to antagonize the epithelial to mesenchymal transition (EMT) by interfering with the function of the lncRNA Hotair (I) Ricerche UNIVERSITARIE
(ex ricerche di ATENEO) codice RM11916B6A80C2CF
2018 Study of tissue environmental cues inactivating the master regulator of hepatocyte differentiation, Hepatocyte Nuclear Factor 4, in liver diseases (I) Ricerche
UNIVERSITARIE (ex ricerche di ATENEO) codice RM1181643646188C
2021 Deciphering the role of m6A on HOTAIR function and EV-compartmentalization (PI) SEED PNR- Finanziamento di progetti di ricerca su temi di interesse trasversale
per il PNR

Part VII – Research Activities
Keywords
Transcriptional factors
Cell plasticity
Chromatin
ncRNAs
Cell differentiation
Tumorigenesis
Epithelial-to-mesenchymal transition
Epigenetics
Brief Description
I am interested in molecular mechanisms controlling cell plasticity. In particular I focused my investigation in mechanisms controlling cell differentiation, epithelial-to-mesenchymal transition and tumour onset and dissemination. My collaborators and I elucidated the role of MyoD in the control of p57 (a cyclin-dependent kinase inhibitor) during muscle differentiation through the direct binding to the chromatin, and of CTCF in the reorganization of chromatin structure in the same phenomenon. In three recent studies, I projected, developed and then elucidated with my team members the role and regulation of a lncRNA, HOTAIR, in the progression of epithelial-to-mesenchymal transition. Specifically, I found that this lncRNA binds to the chromatin, together with the transcriptional factor Snail, in order to recruit chromatin modifiers on the promoters of epithelial genes. Then I focused on its transcriptional regulation, mainly mediated by another transcriptional factor, HNF4a, that binds to its promoter and enhancer and modifies a higher-order chromatin structure promoting HOTAIR transcription. More recently I designed a strategy to counteract HOTAIR function in epithelial-to-mesenchymal transition through an RNA-based approach counteracting HOTAIR-Snail interaction and chromatin modifications on the promoter regions of Snail-target epithelial genes.
I am presently involved in research projects related to the identification of RNA-binding proteins interacting with microRNAs and responsible for microRNAs loading inside extracellular vesicles, specifically into exosomes. In this scenario I am also investigating the role of epitranscriptomics in modulating microRNA-protein interaction both in epithelial-to-mesenchymal transition and during differentiation.
Moreover, I have been implicated in the development and biological application of different epigenetic drugs able to modulate gene expression both in epithelial-to-mesenchymal transition and in tumorigenesis. With respect to this aspect, I focused on the use different inhibitors of chromatin modifiers (DNA methyltransferases, Histone deacetylases, Polycomb repressive complex 2) in order to verify whether they could restore epithelial cell features (and epithelial genes expression rescue) without affecting transcription factor binding to the promoters of several epithelial genes.

Scientific network:
Dr. Chiara Agrati, Istituto Nazionale per le Malattie Infettive "L.Spallanzani", Rome (INMI)
Prof. Andres Ramos, University College of London
Prof. Antonello Mai, Sapienza University of Rome
Prof. Frank J. Gonzalez, Center for Cancer Research, National Cancer Institute, Bethesda
Dr. Rosaria Benedetti, Università degli Studi della Campania "Luigi Vanvitelli, Naples
Prof. Miguel A. Del Pozo, Centro Nacional de Investigaciones Cardiovasculares Carlos III, Madrid
Prof. Manuel Lopez-Cabrera, Centro De Biología Molecular Severo Ochoa, Madrid
Prof. Jadwiga Handzlik, Jagiellonian University, Kraków, Poland
Prof. Claus Jacob, Universität des Saarlandes, Saarbrücken, Germany
Dr. Daniela Trisciuoglio, Italian National Research Council, Rome (CNR)
Dr. Loredana Cifaldi, University of Rome Tor Vergata

Part VIII – Summary of Scientific Achievements (papers published from 2012 to 2022)
Product type Number Data Base
Papers [international] 38 Scopus
https://www.scopus.com/author/submit/profile.uri?authorId=55371458900
2012 2022
Papers [international] 40 Google Scholar
https://scholar.google.it/citations?user=RTOf_14AAAAJ&hl=it&authuser=1&oi=ao
2012 2022

Scopus* Google Scholar*
Total Impact factor 268.036 268.036
Impact factor per product 7.05 6.70
First name products 12 13
Last name products 3 4
Corresponding author products 4 5
Total Citations 968 1185
Average Citations per Product. 25.47 29.63
Hirsch (H) index 16 17
Normalized H index** 1.14 1.21

All data were updated on 17/03/2022
*IF 2021
**H index divided by the academic seniority.

Part IX – Publications:
1) MyoD regulates p57kip2 expression by interacting with a distant cis-element and modifying a higher order chromatin structure
Authors: A. Busanello*, C. Battistelli*, M. Carbone, C. Mostocotto and R. Maione
*First authors
Nucleic Acids Res.2012 Sep 1;40(17):8266-75. doi:10.1093/nar/gks619. Epub 2012 Jun 26.PMID: 22740650
Journal: Nucleic Acids Research; IF 2012: 8.278

2) Functional interplay between MyoD and CTCF in regulating long-range chromatin interactions during differentiation
Authors: C. Battistelli, A. Busanello and R. Maione
J Cell Sci. 2014 Sep 1;127(Pt 17):3757-67. doi: 10.1242/jcs.149427. Epub 2014 Jul 7. PMID: 25002401 Journal: Journal of Cell Science; IF 2014: 5.432

3) Epigenetic control of EMT/MET dynamics: HNF4α impacts DNMT3s through miRs-29
Authors: C. Cicchini, V. de Nonno, C. Battistelli, A. M. Cozzolino, M. De Santis Puzzonia, S. A. Ciafrè, C. Brocker, F. J. Gonzalez, L. Amicone, and M. Tripodi
Biochim Biophys Acta. 2015 Aug;1849(8):919-29. doi: 10.1016/j.bbagrm.2015.05.005. Epub 2015 May 21.
PMID: 26003733
Journal: Biochimica et Biophysica Acta - Gene Regulatory Mechanisms; IF 2015: 5.373

4) Modulating the Substrate Stiffness to Manipulate Differentiation of Resident Liver Stem Cells and to Improve the Differentiation State of Hepatocytes
Authors: A. M. Cozzolino, V. Noce, C. Battistelli, A. Marchetti, G. Grassi, C. Cicchini, M. Tripodi, and L. Amicone
Stem Cells Int. 2016;2016:5481493. doi: 10.1155/2016/5481493. Epub 2016 Jan 12. PMID: 27057172 Journal: Stem Cells International; IF 2016: 3.540

5) Molecular Mechanisms Underlying Peritoneal EMT and Fibrosis
Authors: R. Strippoli, R. Moreno-Vicente, C. Battistelli, C. Cicchini, V. Noce, L. Amicone, A. Marchetti, M. A. del Pozo, and M. Tripodi
Stem Cells Int. 2016;2016:3543678. doi: 10.1155/2016/3543678. Epub 2016 Jan 31. PMID: 26941801 Journal: Stem Cells International; IF 2016: 3.540

6) The RNA-Binding Protein SYNCRIP Is a Component of the Hepatocyte Exosomal Machinery Controlling MicroRNA Sorting
Authors: L. Santangelo, G. Giurato, C. Cicchini, C. Montaldo, C. Mancone, R. Tarallo, C. Battistelli, T. Alonzi, A. Weisz, and M. Tripodi
Cell Rep. 2016 Oct 11;17(3):799-808. doi: 10.1016/j.celrep.2016.09.031. PMID: 27732855
Journal: Cell Reports; IF 2016: 8.282

7) A cross-talk between DNA methylation and H3 lysine 9 dimethylation at the KvDMR1 region controls the induction of Cdkn1c in muscle cells
Authors: O. Andresini, A. Ciotti, M. N. Rossi, C. Battistelli, M. Carbone, and R. Maione
Epigenetics. 2016 Nov;11(11):791-803. doi: 10.1080/15592294.2016.1230576. Epub 2016 Sep 9. PMID: 27611768
Journal: Epigenetics; IF 2016: 4.394

8) Functional Roles and Therapeutic Applications of Exosomes in Hepatocellular Carcinoma
Authors: L. Santangelo, C. Battistelli, C. Montaldo, F. Citarella, R. Strippoli and C. Cicchini
Biomed Res Int. 2017;2017:2931813. doi: 10.1155/2017/2931813. Epub 2017 Feb 7. PMID: 28265569 Journal: BioMed Research International; IF 2017: 2.583

9) The Snail repressor recruits EZH2 to specific genomic sites through the enrollment of the lncRNA HOTAIR in epithelial-to-mesenchymal transition
Authors: C. Battistelli, C. Cicchini, L. Santangelo, A. Tramontano, L. Grassi, F. J. Gonzalez, V. de Nonno, G. Grassi, L. Amicone and M. Tripodi
Oncogene. 2017 Feb 16;36(7):942-955. doi: 10.1038/onc.2016.260. Epub 2016 Jul 25. PMID: 27452518 Journal: Oncogene; IF 2017: 6.854

10) SMO inhibition modulates cellular plasticity and invasiveness in colorectal cancer
Authors: P. Magistri*, C. Battistelli*, R. Strippoli, N. Petrucciani, T. Pellinen, L. Rossi, L. Mangogna, P. Aurello, F. D’Angelo, M. Tripodi, G. Ramacciato and G. Nigri
*First authors
Front Pharmacol. 2018 Feb 2;8:956. doi: 10.3389/fphar.2017.00956. eCollection 2017. PMID: 29456503 Journal: Frontiers in Pharmacology; IF 2018: 3.831

11) Hepatitis C virus direct-acting antivirals therapy impacts on extracellular vesicles microRNAs content and on their immunomodulating properties
Authors: L. Santangelo, V. Bordoni, C. Montaldo, E. Cimini, A. Zingoni, C. Battistelli, G. D’Offizi, M. R. Capobianchi, A. Santoni, M. Tripodi and C. Agrati
Liver Int. 2018 Oct;38(10):1741-1750. doi: 10.1111/liv.13700. Epub 2018 Feb 24. PMID: 29359389
Journal: Liver International; IF 2018: 5.542

12) A cryptic RNA-binding domain mediates Syncrip recognition and exosomal partitioning of miRNA targets
Authors: F. Hobor, A. Dallmann, N. J. Ball, C. Cicchini, C. Battistelli, R. W. Ogrodowicz, E. Christodoulou, S. R. Martin, A. Castello, M. Tripodi, I. A. Taylor and A. Ramos
Nat Commun. 2018 Feb 26;9(1):831. doi: 10.1038/s41467-018-03182-3. PMID: 29483512
Journal: Nature Communications; IF 2018: 11.878

13) HDAC1 inhibition by MS-275 in mesothelial cells limits cellular invasion and promotes MMT reversal
Authors: L. Rossi*, C. Battistelli*, V. de Turris, V. Noce, C. Zwergel, S. Valente, A. Moioli, A. Manzione, M. Palladino, V. Bordoni, A. Domenici, P. Menè, A. Mai, M. Tripodi and R. Strippoli
*First authors
Sci Rep. 2018 May 31;8(1):8492. doi: 10.1038/s41598-018-26319-2. PMID: 29855565
Journal: Scientific Reports; IF 2018: 4.011

14) TGFβ impairs HNF1α functional activity in Epithelial-to-Mesenchymal Transition interfering with the recruitment of CBP/p300 acetyltransferases
Authors: F. Bisceglia*, C. Battistelli*, V. Noce, C. Montaldo, A. Zammataro, R. Strippoli, M. Tripodi, L. Amicone and A. Marchetti
*First authors
Front Pharmacol. 2019 Aug 30;10:942. doi: 10.3389/fphar.2019.00942. eCollection 2019. PMID: 31543815 Journal: Frontiers in Pharmacology; IF 2019: 4.225

15) Development of alkyl glycerone phosphate synthase inhibitors: Structure-activity relationship and effects on ether lipids and epithelial-mesenchymal transition in cancer cells
Authors: G. Stazi*, C. Battistelli*, V. Piano, R. Mazzone, B. Marrocco, S. Marchese, S. M. Louie, C. Zwergel, L. Antonini, A. Patsilinakos, R. Ragno, M. Viviano, G. Sbardella, A. Ciogli, G. Fabrizi, R. Cirilli, R. Strippoli, A. Marchetti, M. Tripodi, D. K. Nomura, A. Mattevi, A. Mai and S. Valente
*First authors
Eur J Med Chem. 2019 Feb 1;163:722-735. doi: 10.1016/j.ejmech.2018.11.050. Epub 2018 Nov 28. PMID: 30576903
Journal: European Journal of Medicinal Chemistry; IF 2019: 5.572

16) The lncRNA HOTAIR transcription is controlled by HNF4α-induced chromatin topology modulation
Authors: C. Battistelli, G. Sabarese, L. Santangelo, C. Montaldo, F. J. Gonzalez, M. Tripodi and C. Cicchini
Cell Death Differ. 2019 May;26(5):890-901. doi: 10.1038/s41418-018-0170-z. Epub 2018 Aug 28. PMID: 30154449
Journal: Cell Death and Differentiation; IF 2019: 10.717

17) Identification of a novel quinoline-based DNA demethylating compound highly potent in cancer cells
Authors: C. Zwergel, M. Schnekenburger, F. Sarno, C. Battistelli, M. C. Manara, G. Stazi, R. Mazzone, R. Fioravanti, C. Gros, F. Ausseil, C. Florean, A. Nebbioso, R. Strippoli, T. Ushijima, K. Scotlandi, M. Tripodi, P. B. Arimondo, L. Altucci, M. Diederich, A. Mai and S. Valente
Clin Epigenetics. 2019 May 6;11(1):68. doi: 10.1186/s13148-019-0663-8. PMID: 31060628
Journal: Clinical Epigenetics; IF 2019: 5.028

18) Caveolin1 and YAP drive mechanically-induced mesothelial to mesenchymal transition and fibrosis
Authors: R. Strippoli, P. Sandoval, R. Moreno-Vicente, L. Rossi, C. Battistelli, M. Terri, L. Pascual-Antón, M. Loureiro, F. Matteini, E. Calvo, J. A. Jiménez-Heffernan, M. J. Gómez, V. Jiménez-Jiménez, F. Sánchez-Cabo, J. Vázquez, M. Tripodi, M. López-Cabrera and M. Á. del Pozo
Cell Death Dis. 2020 Aug 3;11(8):647. doi: 10.1038/s41419-020-02822-1. PMID: 32811813
Journal: Cell Death and Disease; IF 2020: 6.304

19) The innovative potential of selenium-containing agents for fighting cancer and viral infections
Authors: W. Ali, R. Benedetti, J. Handzlik, C. Zwergel and C. Battistelli
Accepted manuscript (19/10/2020), in press, https://doi.org/10.1016/j.drudis.2020.10.014
Journal: Drug Discovery Today; IF 2020: 7.321

20) Design and functional validation of a mutant variant of the lncRNA HOTAIR to counteract Snail function in Epithelial-to-Mesenchymal Transition
Authors: C. Battistelli#, S. Garbo, V. Riccioni, C. Montaldo, L. Santangelo, A. Vandelli, R. Strippoli, G. G. Tartaglia, M. Tripodi# and C. Cicchini
#Corresponding authors
Accepted manuscript (27/10/2020), in press.
Journal: Cancer Research; IF 2020: 9.727

21) Spike-in SILAC proteomic approach reveals the vitronectin as an early molecular signature of liver fibrosis in hepatitis C infections with hepatic iron overload.
Authors: Montaldo C, Mattei S, Baiocchini A, Rotiroti N, Del Nonno F, Pucillo LP, Cozzolino AM, Battistelli C, Amicone L, Ippolito G, van Noort V, Conigliaro A, Alonzi T, Tripodi M, Mancone C.
Proteomics. 2014 May;14(9):1107-15. doi: 10.1002/pmic.201300422. PMID: 24616218
Journal: Proteomics; IF 2014 3.807

22) Poly(ADP-ribosyl)ation is required to modulate chromatin changes at c-MYC promoter during emergence from quiescence.
Authors: Mostocotto C, Carbone M, Battistelli C, Ciotti A, Amati P, Maione R.
PLoS One. 2014 Jul 21;9(7):e102575. doi: 10.1371/journal.pone.0102575. eCollection 2014. PMID: 25047032
Journal: Plos One; IF 2014 3.234

23) SETDB1 is a new promising target in HCC therapy.
Authors: Cicchini C, Battistelli C, Tripodi M.
Chin Clin Oncol. 2016 Dec;5(6):73. doi: 10.21037/cco.2016.05.04. Epub 2016 Jun 3. PMID: 27334461
Journal: Chin Clin Oncol.; IF 2016 n.d.

24) Targeting of polycombs to DNA in EMT.
Authors: Battistelli C, Tripodi M, Cicchini C.
Oncotarget. 2017 Aug 12;8(35):57936-57937. doi: 10.18632/oncotarget.20211. eCollection 2017 Aug 29.
PMID: 28938527
Journal: Oncotarget; IF 2017 n.d.

25) Promotion of proliferation and metastasis of hepatocellular carcinoma by LncRNA00673 based on the targeted-regulation of notch signaling pathway
Authors: P Magistri 1, C Battistelli, G Assirati, F Mereu, G Tarantino, G P Guerrini, R Ballarin, F Di Benedetto
Eur Rev Med Pharmacol Sci. 2017 Oct;21(19):4261-4262. PMID: 29077173
Journal: Eur Rev Med Pharmacol Sci. IF 2017: 2.387

26) The lncRNA H19 positively affects the tumorigenic properties of glioblastoma cells and contributes to NKD1 repression through the recruitment of EZH2 on its promoter.
Authors: Fazi B, Garbo S, Toschi N, Mangiola A, Lombari M, Sicari D, Battistelli C, Galardi S, Michienzi A, Trevisi G, Harari-Steinfeld R, Cicchini C, Ciafrè SA.
Oncotarget. 2018 Feb 14;9(21):15512-15525. doi: 10.18632/oncotarget.24496. eCollection 2018 Mar 20. PMID: 29643989
Journal: Oncotarget; IF 2018 n.d

27) YAP integrates the regulatory Snail/HNF4α circuitry controlling epithelial/hepatocyte differentiation.
Authors: Noce V, Battistelli C, Cozzolino AM, Consalvi V, Cicchini C, Strippoli R, Tripodi M, Marchetti A, Amicone L.
Cell Death Dis. 2019 Oct 10;10(10):768. doi: 10.1038/s41419-019-2000-8. PMID: 31601778
Journal: Cell Death and Disease; IF 2019: 6.304

28) Molecular Mechanisms and New Therapeutic Targets in Epithelial to Mesenchymal Transition (EMT) and Fibrosis.
Authors: Battistelli C, Diederich M, Keane TJ, Sandoval P, Valente S, Strippoli R.
Front Pharmacol. 2020 Jan 16;10:1556. doi: 10.3389/fphar.2019.01556. eCollection 2019. PMID: 32009960
Journal: Frontiers in Pharmacology; IF 2020: 4.225

29) Novel Quinoline Compounds Active in Cancer Cells through Coupled DNA Methyltransferase Inhibition and Degradation.
Authors: Zwergel C, Fioravanti R, Stazi G, Sarno F, Battistelli C, Romanelli A, Nebbioso A, Mendes E, Paulo A, Strippoli R, Tripodi M, Pechalrieu D, Arimondo PB, De Luca T, Del Bufalo D, Trisciuoglio D, Altucci L, Valente S, Mai A.
Cancers (Basel). 2020 Feb 14;12(2):447. doi: 10.3390/cancers12020447. PMID: 32075099
Journal: Cancers; IF 2020: 6.126

30) Design of First-in-Class Dual EZH2/HDAC Inhibitor: Biochemical Activity and Biological Evaluation in Cancer Cells.
Authors: Romanelli A, Stazi G, Fioravanti R, Zwergel C, Di Bello E, Pomella S, Perrone C, Battistelli C, Strippoli R, Tripodi M, Del Bufalo D, Rota R, Trisciuoglio D, Mai A, Valente S.
ACS Med Chem Lett. 2020 Mar 19;11(5):977-983. doi: 10.1021/acsmedchemlett.0c00014. eCollection 2020 May 14. PMID: 32435414
Journal: ACS Medicinal Chemistry Letters; IF 2020: 3.975

31) Discovery of phenylselenoether-hydantoin hybrids as ABCB1 efflux pump modulating agents with cytotoxic and antiproliferative actions in resistant T-lymphoma.
Authors: Ali W, Spengler G, Kincses A, Nové M, Battistelli C, Latacz G, Starek M, Dąbrowska M, Honkisz-Orzechowska E, Romanelli A, Rasile MM, Szymańska E, Jacob C, Zwergel C, Handzlik J.
Eur J Med Chem. 2020 Aug 15;200:112435. doi: 10.1016/j.ejmech.2020.112435. Epub 2020 May 15. PMID: 32505850
Journal: European Journal of Medicinal Chemistry; IF 2020: 5.572

32) Poly(ADP-ribose) Polymerase 1 (PARP1) restrains MyoD-dependent gene expression during muscle differentiation.
Authors: Matteini F, Andresini O, Petrai S, Battistelli C, Rossi MN, Maione R.
Sci Rep. 2020 Sep 15;10(1):15086. doi: 10.1038/s41598-020-72155-8. PMID: 32934320
Journal: Scientific Reports; IF 2020: 3.998

33) Nutlin-3a enhances Natural Killer cell-mediated killing of neuroblastoma by restoring p53-dependent expression of ligands for NKG2D and DNAM-1 receptors
Authors: I. Veneziani, P. Infante, E. Ferretti, O. Melaiu, C. Battistelli, V. Lucarini, M. Compagnone, C. Nicoletti, A. Castellano, S. Petrini, M. Ognibene, A. Pezzolo, L. Di Marcotullio, L. Moretta, R. Bei, V. Pistoia, D. Fruci, V. Barnaba, F. Locatelli, and L. Cifaldi
Cancer Immunology Research, 2021, 9(2), pp. 170–183
Journal: Cancer Immunology Resarch, IF 2020: 8.728

34) Natural Product Epigenetic Modulators and Inhibitors
Authors: Ntie-Kang, F., Karaman Mayack, B., Valente, S., Battistelli, C.
Frontiers in Pharmacology, 2021, 12, 651395
Journal: Frontiers in Pharmacology; IF 2020: 4.225

35) A novel RNA-based approach to counteract EMT
Authors. Garbo S., Tripodi M., Battistelli C.
Journal: Oncoscience; IF 2020: 3.16

36) SYNCRIP Modulates the Epithelial-Mesenchymal Transition in Hepatocytes and HCC Cells
Authors: Riccioni, V., Trionfetti, F., Montaldo, C., Garbo, S., Marocco, F,. Battistelli, C., Marchetti, A., Strippoli, R., Amicone, L., Cicchini, C., Tripodi, M.
Journal: International Journal of Molecular Sciences; IF 2021: 5.923

37) Fibrogenic signals persist in DAA-treated HCV patients after sustained virological response.
Authors: Montaldo, C., Terri, M., Riccioni, V., Battistelli, C., Bordoni, V., D'Offizi, G., Prado, M.G., Trionfetti, F., Vescovo, T., Tartaglia, E., Strippoli, R., Agrati, C., Tripodi M.
Journal: Journal of Hepatology; IF 2021: 25.083

38) m6A RNA methylation and beyond–the epigenetic machinery and potential treatment options
Authors: Garbo, S., Zwergel, C., Battistelli, C.
Journal: Drug discovery today; IF 2021: 7.851