GIULIO BONTEMPI

Dottore di ricerca

ciclo: XXXVI


supervisore: Marco Tripodi
relatore: Marco Tripodi
co-supervisore: Marco Tripodi

Titolo della tesi: HDAC1-3-mediated regulation of miRNAs and lncRNA H19 expression inhibits the mesothelial to mesenchymal transition (MMT) of primary mesothelial cells

In vitro study of primary mesothelial cells may pave the way for the individuation of therapeutic strategies and to unveil specific prognostic and functional markers of MMT. The specific aim of the study is to investigate the epigenetic regulation and the horizontal transfer of signals leading to peritoneal fibrosis. In particular, we explore in primary cells from patients undergoing peritoneal dialysis the ability of HDAC1-3 inhibition by MS-275 to modulate the expression of non coding RNAs (i.e. miRNAs targeting TGFBR1 and of lnc H19) and their functional impact on mesothelial cell plasticity. Moreover, we analyse EVs transfer miRNAs promoting MMT reversal.

Produzione scientifica

11573/1700487 - 2024 - HDAC1/2 control mesothelium/ovarian cancer adhesive interactions impacting on Talin-1-α5β1-integrin-mediated actin cytoskeleton and extracellular matrix protein remodeling
Terri, Michela; Sandoval, Pilar; Bontempi, Giulio; Montaldo, Claudia; Tomero-Sanz, Henar; De Turris, Valeria; Trionfetti, Flavia; Pascual-Antón, Lucía; Clares-Pedrero, Irene; Battistelli, Cecilia; Valente, Sergio; Zwergel, Clemens; Mai, Antonello; Rosanò, Laura; Del Pozo, Miguel Ángel; Sánchez-Álvarez, Miguel; Cabañas, Carlos; Tripodi, Marco; López-Cabrera, Manuel; Strippoli, Raffaele - 01a Articolo in rivista
rivista: JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH (London : BioMed Central) pp. - - issn: 1756-9966 - wos: (0) - scopus: (0)

11573/1702828 - 2024 - Mechanisms of mesothelial cell response to viral infections: HDAC1-3 inhibition blocks poly(I:C)-induced type I interferon response and modulates the mesenchymal/inflammatory phenotype
Trionfetti, Flavia; Montaldo, Claudia; Caiello, Ivan; Bontempi, Giulio; Terri, Michela; Tiberi, Marta; Marchant, Vanessa; Domenici, Alessandro; Menè, Paolo; Cordani, Marco; Zwergel, Clemens; Prencipe, Giusi; Ruiz-Ortega, Marta; Valente, Sergio; Mai, Antonello; Tripodi, Marco; Strippoli, Raffaele - 01a Articolo in rivista
rivista: FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY (Lausanne : Frontiers Media SA, 2011-) pp. - - issn: 2235-2988 - wos: WOS:001180097600001 (0) - scopus: (0)

11573/1662777 - 2023 - Novel pyridine-containing histone deacetylase inhibitors strongly arrest proliferation, induce apoptosis and modulate miRNAs in cancer cells
Di Bello, Elisabetta; Sian, Veronica; Bontempi, Giulio; Zwergel, Clemens; Fioravanti, Rossella; Noce, Beatrice; Castiello, Carola; Tomassi, Stefano; Corinti, Davide; Passeri, Daniela; Pellicciari, Roberto; Mercurio, Ciro; Varasi, Mario; Altucci, Lucia; Tripodi, Marco; Strippoli, Raffaele; Nebbioso, Angela; Valente, Sergio; Mai, Antonello - 01a Articolo in rivista
rivista: EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY (Editions Scientifique & Medical Elsevier:23 Rue Linois, F 75724 Paris Cedex 15 France:011 33 1 71724646, INTERNET: http://www.elsevier.fr, Fax: 011 33 1 71724664) pp. 115022- - issn: 0223-5234 - wos: WOS:000911596400001 (6) - scopus: 2-s2.0-85144323384 (5)

11573/1695097 - 2023 - BET Protein Inhibitor JQ1 Ameliorates Experimental Peritoneal Damage by Inhibition of Inflammation and Oxidative Stress
Marchant, Vanessa; Trionfetti, Flavia; Tejedor-Santamaria, Lucia; Rayego-Mateos, Sandra; Rotili, Dante; Bontempi, Giulio; Domenici, Alessandro; Menè, Paolo; Mai, Antonello; Martín-Cleary, Catalina; Ortiz, Alberto; Ramos, Adrian M.; Strippoli, Raffaele; Ruiz-Ortega, Marta - 01a Articolo in rivista
rivista: ANTIOXIDANTS (Basel: MDPI) pp. 1-19 - issn: 2076-3921 - wos: WOS:001137851500001 (0) - scopus: 2-s2.0-85180466019 (0)

11573/1696065 - 2023 - HDAC1-3 inhibition increases SARS-CoV-2 replication and productive infection in lung mesothelial and epithelial cells
Trionfetti, Flavia; Alonzi, Tonino; Bontempi, Giulio; Terri, Michela; Battistelli, Cecilia; Montaldo, Claudia; Repele, Federica; Rotili, Dante; Valente, Sergio; Zwergel, Clemens; Matusali, Giulia; Maggi, Fabrizio; Goletti, Delia; Tripodi, Marco; Mai, Antonello; Strippoli, Raffaele - 01a Articolo in rivista
rivista: FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY (Lausanne : Frontiers Media SA, 2011-) pp. - - issn: 2235-2988 - wos: WOS:001130489700001 (1) - scopus: (0)

11573/1691462 - 2023 - POLY(I:C) INDUCES MORPHOLOGICAL CHANGES AND TYPE I INTERFERON-MEDIATED INFLAMMATORY RESPONSE IN MESOTHELIAL CELLS FROM PERITONEUM
Trionfetti, Flavia; Marchant, Vanessa; Terri, Michela; Bontempi, Giulio; Domenici, Alessandro; Mene, Paolo; Ruiz-Ortega, Marta; Strippoli, Raffaele - 01h Abstract in rivista
rivista: NEPHROLOGY DIALYSIS TRANSPLANTATION (Oxford: Oxford University Press.) pp. 1164-1164 - issn: 1460-2385 - wos: WOS:001022961100156 (0) - scopus: (0)

11573/1659806 - 2022 - Restoration of WT1/miR-769-5p axis by HDAC1 inhibition promotes MMT reversal in mesenchymal-like mesothelial cells
Bontempi, Giulio; Terri, Michela; Garbo, Sabrina; Montaldo, Claudia; Mariotti, Davide; Bordoni, Veronica; Valente, Sergio; Zwergel, Clemens; Mai, Antonello; Marchetti, Alessandra; Domenici, Alessandro; Menè, Paolo; Battistelli, Cecilia; Tripodi, Marco; Strippoli, Raffaele - 01a Articolo in rivista
rivista: CELL DEATH & DISEASE (Nature Group) pp. 965- - issn: 2041-4889 - wos: WOS:000885083500004 (10) - scopus: 2-s2.0-85142134241 (9)

11573/1612876 - 2022 - Exposure to b‐LED light while exerting antimicrobial activity on Gram‐negative and ‐positive bacteria promotes transient EMT‐like changes and growth arrest in keratinocytes
Terri, M.; Mancianti, N.; Trionfetti, F.; Casciaro, B.; De Turris, V.; Raponi, G.; Bontempi, G.; Montaldo, C.; Domenici, A.; Mene', P.; Mangoni, M. L.; Strippoli, R. - 01a Articolo in rivista
rivista: INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (Basel (Matthaeustrasse 11) : Molecular Diversity Preservation International MDPI) pp. - - issn: 1661-6596 - wos: WOS:000755651500001 (2) - scopus: 2-s2.0-85124280849 (2)

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