BEATRICE NOCE

PhD Student

PhD program:: XXXVII
email: beatrice.noce@uniroma1.it
building: Dipartimento di Chimica e Tecnologia del Farmaco
room: Lab 116

supervisor: Prof. Antonello Mai
co-supervisor: Prof. Sergio Valente

Research: Identification and development of human NADPH oxidase (NOX) inhibitors with a role in cancer

Curriculum vitae of Beatrice Noce ABOUT ME Born in 1996, I am extremely motivated to constantly develop my skills and grow professionally.I am ambitious and results-oriented. My university experience in the laboratory of Prof. Antonello Mai and, also, my greatest hobby, the theater workshop, have made me methodical, quick in solving problems and very sociable. EDUCATION 01/11/2021- present SAPIENZA UNIVERSITÀ DI ROMA, PHD IN SCIENZE FARMACEUTICHE – TUTOR PROF. ANTONELLO MAI I practice the design and the syntesis of new potential inhibitors of epigenetic (or not) targets and, also, the characterization of organic compounds. I interpret results obtained by spectroscopic techniques (LC-MS,NMR) and I practice different processes of purification (TLC, Liquid Chromatography, double phase extraction). January 2020- January 2021 Experimental Thesis in PharmaceuticalChemistry (Group of Prof. Antonello Mai) Title of the thesis: "Progettazione, sintesi e profilobiochimico di nuovi potenziali inibitori della NADPHossidasi 5 (NOX-5)" October 2015 - January 2021 Master's Degree in Pharmaceutical Chemistry and Technology 110/110 cum laude September 2010- July 2015 LICEO SCIENTIFICO G. SULPICIO (Veroli-Fr) High school leaving certificate in scientific studies 100/100 LANGUAGE SKILLS Mother tongue: Italian Other Languages: English; Spanish COMPUTER SKILLS Good Knowledge of data analysis and editing software (i.e Excel, Word, Power point). Experience in performing literature searches using chemistry databases (PubMed, SciFinder, Reaxys) and in applying the results to solve synthetic challenges in the lab.

Research products

11573/1662777 - 2023 - Novel pyridine-containing histone deacetylase inhibitors strongly arrest proliferation, induce apoptosis and modulate miRNAs in cancer cells

Di Bello, Elisabetta; Sian, Veronica; Bontempi, Giulio; Zwergel, Clemens; Fioravanti, Rossella; Noce, Beatrice; Castiello, Carola; Tomassi, Stefano; Corinti, Davide; Passeri, Daniela; Pellicciari, Roberto; Mercurio, Ciro; Varasi, Mario; Altucci, Lucia; Tripodi, Marco; Strippoli, Raffaele; Nebbioso, Angela; Valente, Sergio; Mai, Antonello - 01a Articolo in rivista

paper: EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY (Editions Scientifique & Medical Elsevier:23 Rue Linois, F 75724 Paris Cedex 15 France:011 33 1 71724646, INTERNET: http://www.elsevier.fr, Fax: 011 33 1 71724664) pp. 115022- - issn: 0223-5234 - wos: WOS:000911596400001 (2) - scopus: 2-s2.0-85144323384 (3)

11573/1670227 - 2023 - LSD1 inhibitors for cancer treatment: Focus on multi-target agents and compounds in clinical trials

Noce, Beatrice; Di Bello, Elisabetta; Fioravanti, Rossella; Mai, Antonello - 01g Articolo di rassegna (Review)

paper: FRONTIERS IN PHARMACOLOGY (Lausanne: Frontiers Media S.A., 2010-) pp. - - issn: 1663-9812 - wos: WOS:000935304500001 (11) - scopus: 2-s2.0-85148335525 (17)

11573/1658358 - 2023 - Chemically diverse S. mansoni HDAC8 inhibitors reduced viability in worm larval and adult stages

Noce, Beatrice; Di Bello, Elisabetta; Zwergel, Clemens; Fioravanti, Rossella; Valente, Sergio; Rotili, Dante; Masotti, Andrea; Ansari, Mohammad Salik Zeya; Trisciuoglio, Daniela; Chakrabarti, Alokta; Romier, Christophe; Robaa, Dina; Sippl, Wolfgang; Jung, Manfred; Häberli, Cécile; Keiser, Jennifer; Mai, Antonello - 01a Articolo in rivista

paper: CHEMMEDCHEM (Weinheim : Wiley-VCH-Verl..) pp. - - issn: 1860-7179 - wos: WOS:000879912800001 (3) - scopus: 2-s2.0-85141693563 (2)

11573/1691312 - 2023 - Targeting ROS production through inhibition of NADPH oxidases

Reis, Joana; Gorgulla, Christoph; Massari, Marta; Marchese, Sara; Valente, Sergio; Noce, Beatrice; Basile, Lorenzo; Törner, Ricarda; Cox, Huel; Viennet, Thibault; Yang, Moon Hee; Ronan, Melissa M; Rees, Matthew G; Roth, Jennifer A; Capasso, Lucia; Nebbioso, Angela; Altucci, Lucia; Mai, Antonello; Arthanari, Haribabu; Mattevi, Andrea - 01a Articolo in rivista

paper: NATURE CHEMICAL BIOLOGY (New York, N.Y. : Nature Pub. Group, 2005-) pp. 1540-1550 - issn: 1552-4469 - wos: WOS:001090044900002 (1) - scopus: 2-s2.0-85174921719 (2)

11573/1684985 - 2023 - Novel 1,4-Dihydropyridines as Specific Binders and Activators of SIRT3 Impair Cell Viability and Clonogenicity and Downregulate Hypoxia-Induced Targets in Cancer Cells

Zwergel, Clemens; Aventaggiato, Michele; Garbo, Sabrina; Di Bello, Elisabetta; Fassari, Bruno; Noce, Beatrice; Castiello, Carola; Lambona, Chiara; Barreca, Federica; Rotili, Dante; Fioravanti, Rossella; Schmalz, Thomas; Weyand, Michael; Niedermeier, Amelie; Tripodi, Marco; Colotti, Gianni; Steegborn, Clemens; Battistelli, Cecilia; Tafani, Marco; Valente, Sergio; Mai, Antonello - 01a Articolo in rivista

paper: JOURNAL OF MEDICINAL CHEMISTRY (Washington, DC: American Chemical Society) pp. 9622-9641 - issn: 0022-2623 - wos: WOS:001027732800001 (5) - scopus: 2-s2.0-85165671509 (3)

11573/1644085 - 2022 - Current HDAC Inhibitors in Clinical Trials

Di Bello, Elisabetta; Noce, Beatrice; Fioravanti, Rossella; Mai, Antonello - 01g Articolo di rassegna (Review)

paper: CHIMIA (Swiss Chemical Society:Barenplatz 2, CH 3011 Bern Switzerland:011 41 31 3104090, EMAIL: info@swiss-chem-soc.ch, markus.straub@swiss-chem-soc.ch, INTERNET: http://www.swiss-chem-soc.ch, Fax: 011 41 31 3121678) pp. 448-453 - issn: 0009-4293 - wos: WOS:000929447400008 (5) - scopus: 2-s2.0-85132577121 (8)

11573/1650772 - 2022 - Effects of Structurally Different HDAC Inhibitors against Trypanosoma cruzi, Leishmania, and Schistosoma mansoni

Di Bello, Elisabetta; Noce, Beatrice; Fioravanti, Rossella; Zwergel, Clemens; Valente, Sergio; Rotili, Dante; Fianco, Giulia; Trisciuoglio, Daniela; Mourão, Marina M; Sales, Policarpo; Lamotte, Suzanne; Prina, Eric; Späth, Gerald F; Häberli, Cécile; Keiser, Jennifer; Mai, Antonello - 01a Articolo in rivista

paper: ACS INFECTIOUS DISEASES (Washington, DC : American Chemical Society, 2015-) pp. 1356-1366-1366 - issn: 2373-8227 - wos: WOS:000819851400001 (11) - scopus: 2-s2.0-85134360722 (11)

11573/1623778 - 2022 - Heterocycle-containing tranylcypromine derivatives endowed with high anti-LSD1 activity

Fioravanti, Rossella; Rodriguez, Veronica; Caroli, Jonatan; Chianese, Ugo; Benedetti, Rosaria; Di Bello, Elisabetta; Noce, Beatrice; Zwergel, Clemens; Corinti, Davide; Viña, Dolores; Altucci, Lucia; Mattevi, Andrea; Valente, Sergio; Mai, Antonello - 01a Articolo in rivista

paper: JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY (Taylor & Francis Limited:Rankine Road, Basingstoke RG24 8PR United Kingdom:011 44 1256 813035, EMAIL: madeline.sims@tandf.co.uk, info@tandf.co.uk, INTERNET: http://www.tandf.co.uk, Fax: 011 44 1256 330245) pp. 973-985 - issn: 1475-6366 - wos: WOS:000771778600001 (1) - scopus: 2-s2.0-85126852334 (1)