AWA DIOP

PhD Student

PhD program:: XXXVI
email: awa.diop@uniroma1.it
phone: 49910879
building: Dipartimento di Biochimica A. Rossi Fanelli CU027
room: 217




supervisor: Stefano Gianni
co-supervisor: Stefano Gianni

Research: Understanding the mechanism of binding of MATH and SPRY domains

Education:
- 2016- 2017: MSc degree Research in Bioinformatic, structural Biochemistry and genomic, Specialized in structural biochemistry - Aix Marseille University, Faculty of sciences and technologies of Luminy (FRANCE)
Courses: Bioinformatic (sequence alignment and analysis, database search), Crystallogenesis, TEM sample preparation, NMR, Structural Enzymology and Integrative Biology

- 2014- 2016: MSc degree in Sciences of medicine- specialized on drug design, Faculty of Pharmacy, University Lille 2 (FRANCE)
2011-2014 BSc degree in Biochemistry and pharmaceutical biology, Faculty of science and technology of Luminy Aix Marseille University (AMU)

- 2010-2011: Scientific Baccalaureate (S), DJIGNABO High school, ZIGUINCHOR (SENEGAL)

Research experience:

- January-June 2017
Master 2 internship in structural biochemistry_ AFMB Marseille, Virales replicases’ team « structure, Mechanism and Drug design »
Characterization of arenaviruses’ nucleoprotein (NP): Mopeia (MOPV) and LCMV, under the supervision of Ph.D. FERRON François (CNRS Researcher)

- February-June 2016
Master 2 internship on Microbiology _ProBioGEM, Charles Viollette’s Institute, University of Lille1
Study of the influence of pnpAse on the biosynthesis of fengycin and surfactin, supervised by PhD GANCEL Frédérique (Lecturer of Lille 1 University)

-November 2014-June 2015
Master 1 internship in vocational training format at the molecular interaction’s platform of University Lille 2
Study of the interaction YAP/TEAD4 and the potentials inhibitors of this interaction by Micro Scale Thermophoresis (MST) and Surface Plasmon Resonance (SPR), with PhD. FOULON Catherine (Lecturer of Lille2 University)

- February–April 2014
Bachelor internship – CNRS (Laboratoire d’Ingénierie des Systèmes Macromoléculaires) Marseille
Biosynthesis of carotenoids in bacteria, by cloning and PCR, with Pr. STURGIS James (Lecturer of Aix Marseille University)

Articles:

- “Polynucleotide phosphorylase is involved in the control of lipopeptide fengycin production in Bacillus subtilis” Yazen Yaseen, Awa Diop, Frédérique Gancel, Max Béchet, Philippe Jacques, Djamel Drider (Archives of Microbiology)

- “Observation of arenavirus nucleoprotein heptamer assembly” Papageorgiou N, Vasilopoulo A, Diop A,... Ferron F, FEBS Open Bio

Research products

11573/1706810 - 2024 - The binding selectivity of the C-terminal SH3 domain of Grb2, but not its folding pathway, is dictated by its contiguous SH2 domain
Di Felice, Mariana; Pagano, Livia; Pennacchietti, Valeria; Diop, Awa; Pietrangeli, Paola; Marcocci, Lucia; Di Matteo, Sara; Malagrinò, Francesca; Toto, Angelo; Gianni, Stefano - 01a Articolo in rivista
paper: THE JOURNAL OF BIOLOGICAL CHEMISTRY (American Society for Biochemistry and Molecular Biology:9650 Rockville Pike:Bethesda, MD 20814:(301)530-7145, EMAIL: asbmb@asbmb.faseb.org, INTERNET: http://www.faseb.org/asbmb, Fax: (301)571-1824) pp. - - issn: 0021-9258 - wos: (0) - scopus: 2-s2.0-85188713900 (0)

11573/1707732 - 2024 - The Mechanism of Folding of Human Frataxin in Comparison to the Yeast Homologue – Broad Energy Barriers and the General Properties of the Transition State
Pietrangeli, Paola; Marcocci, Lucia; Pennacchietti, Valeria; Diop, Awa; Di Felice, Mariana; Pagano, Livia; Malagrinò, Francesca; Toto, Angelo; Brunori, Maurizio; Gianni, Stefano - 01a Articolo in rivista
paper: JOURNAL OF MOLECULAR BIOLOGY (-LONDON, ENGLAND: ACADEMIC PRESS LTD ELSEVIER SCIENCE LTD, -London; New York: Academic Press.) pp. - - issn: 0022-2836 - wos: (0) - scopus: (0)

11573/1683686 - 2023 - Biophysical characterization of the binding mechanism between the MATH domain of SPOP and its physiological partners
Diop, Awa; Pietrangeli, Paola; Nardella, Caterina; Pennacchietti, Valeria; Pagano, Livia; Toto, Angelo; Di Felice, Mariana; Di Matteo, Sara; Marcocci, Lucia; Malagrinò, Francesca; Gianni, Stefano - 01a Articolo in rivista
paper: INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (Basel: MDPI Center) pp. 10138- - issn: 1422-0067 - wos: WOS:001017317000001 (2) - scopus: 2-s2.0-85163977385 (2)

11573/1695759 - 2023 - Addressing the binding mechanism of the Meprin and TRAF-C hmology domain of the Speckle-Type POZ protein using protein engineering
Diop, Awa; Pietrangeli, Paola; Pennacchietti, Valeria; Pagano, Livia; Toto, Angelo; Di Felice, Mariana; Di Matteo, Sara; Marcocci, Lucia; Malagrinò, Francesca; Gianni, Stefano - 01a Articolo in rivista
paper: INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (Basel: MDPI Center) pp. - - issn: 1422-0067 - wos: WOS:001131010700001 (0) - scopus: (0)

11573/1685968 - 2023 - An intramolecular energetic network regulates ligand recognition in a SH2 domain
Nardella, Caterina; Pagano, Livia; Pennacchietti, Valeria; Felice, Mariana Di; Matteo, Sara Di; Diop, Awa; Malagrinò, Francesca; Marcocci, Lucia; Pietrangeli, Paola; Gianni, Stefano; Toto, Angelo - 01a Articolo in rivista
paper: PROTEIN SCIENCE (Cambridge University Press / New York:40 West 20th Street:New York, NY 10011:(800)872-7423, (212)924-3900, EMAIL: journals_subscriptions@cup.org, INTERNET: http://www.journals.cambridge.org, Fax: (212)691-3239) pp. - - issn: 0961-8368 - wos: WOS:001040354200001 (1) - scopus: 2-s2.0-85166371265 (1)

11573/1686025 - 2023 - Characterization of the folding and binding properties of the PTB domain of FRS2 with phosphorylated and unphosphorylated ligands
Pennacchietti, Valeria; Pagano, Livia; Malagrinò, Francesca; Diop, Awa; Di Felice, Mariana; Di Matteo, Sara; Marcocci, Lucia; Pietrangeli, Paola; Toto, Angelo; Gianni, Stefano - 01a Articolo in rivista
paper: ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS (Attuale:ELSEVIER SCIENCE INC, 360 PARK AVE SOUTH, NEW YORK, USA, NY, 10010-1710 Academic Press Incorporated:6277 Sea Harbor Drive:Orlando, FL 32887:(800)543-9534, (407)345-4100, EMAIL: ap@acad.com, INTERNET: http://www.idealibrary.com, Fax: (407)352-3445) pp. 109703- - issn: 0003-9861 - wos: WOS:001053305400001 (0) - scopus: 2-s2.0-85166633882 (0)

11573/1673852 - 2023 - Understanding the molecular basis of folding cooperativity through a comparative analysis of a multidomain protein and its isolated domains
Santorelli, Daniele; Marcocci, Lucia; Pennacchietti, Valeria; Nardella, Caterina; Diop, Awa; Pietrangeli, Paola; Pagano, Livia; Toto, Angelo; Malagrino, Francesca; Gianni, Stefano - 01a Articolo in rivista
paper: THE JOURNAL OF BIOLOGICAL CHEMISTRY (American Society for Biochemistry and Molecular Biology:9650 Rockville Pike:Bethesda, MD 20814:(301)530-7145, EMAIL: asbmb@asbmb.faseb.org, INTERNET: http://www.faseb.org/asbmb, Fax: (301)571-1824) pp. 102983- - issn: 0021-9258 - wos: WOS:001009100600001 (2) - scopus: 2-s2.0-85149793931 (2)

11573/1662469 - 2022 - SH2 Domains: folding, binding and therapeutical approaches
Diop, Awa; Santorelli, Daniele; Malagrinò, Francesca; Nardella, Caterina; Pennacchietti, Valeria; Pagano, Livia; Marcocci, Lucia; Pietrangeli, Paola; Gianni, Stefano; Toto, Angelo - 01a Articolo in rivista
paper: INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (Basel: MDPI Center) pp. 15944- - issn: 1422-0067 - wos: WOS:000902565100001 (5) - scopus: 2-s2.0-85144969444 (4)

11573/1607647 - 2022 - On the effects of disordered tails, supertertiary structure and quinary interactions on the folding and function of protein domains
Malagrino, F.; Pennacchietti, V.; Santorelli, D.; Pagano, L.; Nardella, C.; Diop, A.; Toto, A.; Gianni, S. - 01a Articolo in rivista
paper: BIOMOLECULES (Basel: MDPI) pp. 209- - issn: 2218-273X - wos: WOS:000763931100001 (5) - scopus: 2-s2.0-85123285981 (6)

11573/1651291 - 2022 - Folding and binding mechanisms of the SH2 domain from Crkl
Nardella, Caterina; Toto, Angelo; Santorelli, Daniele; Pagano, Livia; Diop, Awa; Pennacchietti, Valeria; Pietrangeli, Paola; Marcocci, Lucia; Malagrinò, Francesca; Gianni, Stefano - 01a Articolo in rivista
paper: BIOMOLECULES (Basel: MDPI) pp. 1014- - issn: 2218-273X - wos: WOS:000846180000001 (4) - scopus: 2-s2.0-85137360513 (4)

11573/1657644 - 2022 - Exploring the effect of tethered domains on the folding of Grb2 protein
Pagano, Livia; Pennacchietti, Valeria; Diop, Awa; Santorelli, Daniele; Pietrangeli, Paola; Marcocci, Lucia; Nardella, Caterina; Malagrinò, Francesca; Toto, Angelo; Gianni, Stefano - 01a Articolo in rivista
paper: ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS (Attuale:ELSEVIER SCIENCE INC, 360 PARK AVE SOUTH, NEW YORK, USA, NY, 10010-1710 Academic Press Incorporated:6277 Sea Harbor Drive:Orlando, FL 32887:(800)543-9534, (407)345-4100, EMAIL: ap@acad.com, INTERNET: http://www.idealibrary.com, Fax: (407)352-3445) pp. 109444- - issn: 0003-9861 - wos: WOS:000880049100004 (1) - scopus: 2-s2.0-85141826263 (2)

11573/1635685 - 2022 - Characterization of early and late transition states of the folding pathway of a SH2 domain
Toto, Angelo; Malagrinò, Francesca; Nardella, Caterina; Pennacchietti, Valeria; Pagano, Livia; Santorelli, Daniele; Diop, Awa; Gianni, Stefano - 01a Articolo in rivista
paper: PROTEIN SCIENCE (Cambridge University Press / New York:40 West 20th Street:New York, NY 10011:(800)872-7423, (212)924-3900, EMAIL: journals_subscriptions@cup.org, INTERNET: http://www.journals.cambridge.org, Fax: (212)691-3239) pp. - - issn: 0961-8368 - wos: WOS:000798704500001 (3) - scopus: 2-s2.0-85131218830 (3)

11573/1593241 - 2021 - Unveiling induced folding of intrinsically disordered proteins - Protein engineering, frustration and emerging themes
Malagrinò, Francesca; Diop, Awa; Pagano, Livia; Nardella, Caterina; Toto, Angelo; Gianni, Stefano - 01a Articolo in rivista
paper: CURRENT OPINION IN STRUCTURAL BIOLOGY (Current Biology Limited:84 Theobalds Road, London WC1X 8RR United Kingdom:011 44 20 76114202, EMAIL: info@biomednet.com, INTERNET: http://www.biomednet.com, Fax: 011 44 20 76114479) pp. 160-160 - issn: 0959-440X - wos: WOS:000768730600018 (8) - scopus: 2-s2.0-85120903843 (12)

11573/1555353 - 2021 - Observation of arenavirus nucleoprotein heptamer assembly
Papageorgiou, N.; Vaitsopoulou, A.; Diop, A.; Nguyen, T. H. V.; Canard, B.; Alvarez, K.; Ferron, F. - 02a Capitolo o Articolo
book: O - ()

11573/1555351 - 2018 - Polynucleotide phosphorylase is involved in the control of lipopeptide fengycin production in Bacillus subtilis
Yaseen, Y.; Diop, A.; Gancel, F.; Bechet, M.; Jacques, P.; Drider, D. - 02a Capitolo o Articolo
book: O - ()

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