ANTONIO COLUCCIA

Associate professor

email: antonio.coluccia@uniroma1.it
phone:




Research products

11573/1741843 - 2025 - Exploring structure-activity relationships of pyrrolyl diketo acid derivatives as non-nucleoside inhibitors of terminal deoxynucleotidyl transferase enzyme
Madia, Valentina Noemi; Garibaldi, Nadia; Ialongo, Davide; Patacchini, Elisa; Tudino, Valeria; Ruggieri, Giuseppe; Zarbo, Laura; Cara, Emanuele; Coluccia, Antonio; Artico, Marco; Scipione, Luigi; Messore, Antonella; Saccoliti, Francesco; Mentegari, Elisa; Maga, Giovanni; Di Santo, Roberto; Crespan, Emmanuele; Costi, Roberta - 01a Articolo in rivista
paper: JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY (Abingdon Oxfordshire United Kingdom: Taylor & Francis London: Gordon and Breach, 2002-) pp. 1-16 - issn: 1475-6374 - wos: WOS:001504499200001 (0) - scopus: 2-s2.0-105007696685 (0)

11573/1748729 - 2025 - Ferroptosis Induction by a New Pyrrole Derivative in Triple Negative Breast Cancer and Colorectal Cancer
Masci, Domiziana; Ling, Lele; Yang, Lian; Puxeddu, Michela; Colla, Claudia; Coluccia, Antonio; Santelli, Martina; Scio', Pietro; Cuřínová, Petra; Ansari, Mohammad Salik Zeya; Naro, Chiara; Sette, Claudio; Jimenez, Lucia; Link, Wolfgang; Bigogno, Chiara; Dondio, Giulio; Hamel, Ernest; Liu, Te; Silvestri, Romano; La Regina, Giuseppe - 01a Articolo in rivista
paper: JOURNAL OF MEDICINAL CHEMISTRY (Washington, DC: American Chemical Society) pp. 17840-17858 - issn: 0022-2623 - wos: WOS:001547406200001 (0) - scopus: 2-s2.0-105014469330 (0)

11573/1748751 - 2025 - Microwave-assisted synthesis of tubulin assembly inhibitors as anticancer agents by aryl ring reversal and conjunctive approach
Masci, Domiziana; Puxeddu, Michela; Colla, Claudia; Coluccia, Antonio; Santelli, Martina; Scio', Pietro; Mariotto, Elena; Viola, Giampietro; Hamel, Ernest; Lerose, Rosa; Mazzoccoli, Carmela; Silvestri, Romano; La Regina, Giuseppe - 01a Articolo in rivista
paper: RSC MEDICINAL CHEMISTRY (Cambridge: Royal Society of Chemistry, 2020-) pp. - - issn: 2632-8682 - wos: WOS:001538325300001 (0) - scopus: (0)

11573/1738206 - 2025 - Unveiling an unexpected redox regulation of the folding, function and inhibition in the phosphotyrosine binding domain of FRS2
Pennacchietti, Valeria; Pagano, Livia; Di Felice, Mariana; Toso, Julian; Bufano, Marianna; Coluccia, Antonio; Silvestri, Romano; Capelli, Riccardo; Camilloni, Carlo; Malagrinò, Francesca; Toto, Angelo; Gianni, Stefano - 01a Articolo in rivista
paper: INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES (-Attuale :ELSEVIER SCIENCE BV, PO BOX 211, AMSTERDAM, NETHERLANDS, 1000 AE -Butterworth Heinemann Publishers:Linacre House Jordan Hill, Oxford OX2 8DP United Kingdom:011 44 1865 314569, EMAIL: bhmarketing@repp.co.uk, INTERNET: http://www.laxtonsprices.co.uk, Fax: 011 44 1865 314569) pp. - - issn: 0141-8130 - wos: WOS:001469698000001 (0) - scopus: 2-s2.0-105002147407 (0)

11573/1749828 - 2025 - ApaH as a Promising Anti-Virulence Target in Multi-Drug-Resistant Pseudomonas aeruginosa Infections
Pistoia, Gianluca; Cervoni, Matteo; Guidi, Francesca; Travaglini Allocatelli, Carlo; Coluccia, Antonio; Imperi, Francesco; Di Matteo, Adele; Giardina, Giorgio - 04d Abstract in atti di convegno
conference: 1st Interregional Congress of Central Italy in Biochemistry and Molecular Biology (L'Aquila)
book: LAMS_2025_abstracts_book - ()

11573/1749845 - 2025 - Diadenosine tetraphosphate hydrolase (ApaH) as a key regulator of P. aeruginosa virulence: structural and mechanistic insights for drug development
Pistoia, Gianluca; Cervoni, Matteo; Guidi, Francesca; Travaglini Allocatelli, Carlo; Coluccia, Antonio; Imperi, Francesco; Di Matteo, Adele; Giardina, Giorgio - 04d Abstract in atti di convegno
conference: 63rd SIB Congress (Palermo, Italy)
book: 63rd SIB Congress Abstract Book - ()

11573/1753454 - 2025 - Design and synthesis of novel thioether analogs as promising antiviral agents: In vitro activity against enteroviruses of interest
Roux, Hugo; Touret, Franck; Coluccia, Antonio; Scio, Pietro; Bouzidi, Hawa Sophia; Di Giorgio, Carole; Gattacceca, Florence; Khoumeri, Omar; Silvestri, Romano; Vanelle, Patrice; Roche, Manon - 01a Articolo in rivista
paper: EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY (Editions Scientifique & Medical Elsevier:23 Rue Linois, F 75724 Paris Cedex 15 France:011 33 1 71724646, INTERNET: http://www.elsevier.fr, Fax: 011 33 1 71724664) pp. - - issn: 0223-5234 - wos: WOS:001431272700001 (0) - scopus: 2-s2.0-85218147838 (0)

11573/1753672 - 2025 - Retrospective Benchmarking and Novel Shape-Pharmacophore Based Implementation of the MORLD Method for the Autonomous Optimization of 3-Aroyl-1,4-diarylpyrroles (ARDAP)
Scio', Pietro; Bufano, Marianna; Silvestri, Romano; Coluccia, Antonio - 01a Articolo in rivista
paper: JOURNAL OF CHEMICAL INFORMATION AND MODELING (AMER CHEMICAL SOC, 1155 16TH ST, NW, WASHINGTON, USA, DC, 20036) pp. 8819-8832 - issn: 1549-9596 - wos: WOS:001545289300001 (0) - scopus: 2-s2.0-105014127001 (0)

11573/1753651 - 2025 - Identification of a New FtsZ Inhibitor by Virtual Screening, Mechanistic Insights, and Structure–Activity Relationship Analyses
Scio', Pietro; Scoffone, Viola Camilla; Parisi, Anastasia; Bufano, Marianna; Caneva, Martina; Trespidi, Gabriele; Irudal, Samuele; Barbieri, Giulia; Cariani, Lisa; Orena, Beatrice Silvia; Daccò, Valeria; Imperi, Francesco; Buroni, Silvia; Coluccia, Antonio - 01a Articolo in rivista
paper: ACS INFECTIOUS DISEASES (Washington, DC : American Chemical Society, 2015-) pp. 998-1007 - issn: 2373-8227 - wos: WOS:001448298900001 (0) - scopus: 2-s2.0-105000339201 (1)

11573/1753682 - 2025 - Structure-function relationship of the Pseudomonas aeruginosa AsmA-like proteins YhdP and YdbH involved in outer membrane biogenesis
Sposato, Davide; Pederzoli, Camilla; Bufano, Marianna; Scio', Pietro; Rossi, Ludovica; Leoni, Livia; Rampioni, Giordano; Visca, Paolo; Coluccia, Antonio; Imperi, Francesco - 01a Articolo in rivista
paper: PROTEIN SCIENCE (Cambridge University Press / New York:40 West 20th Street:New York, NY 10011:(800)872-7423, (212)924-3900, EMAIL: journals_subscriptions@cup.org, INTERNET: http://www.journals.cambridge.org, Fax: (212)691-3239) pp. - - issn: 0961-8368 - wos: WOS:001574518300001 (0) - scopus: 2-s2.0-105016639072 (0)

11573/1726988 - 2024 - 4-(3-Phenylsulfonylindol-2-yl)-1-(pyridin-2-yl)piperazinyl-methanones as Potent Inhibitors of both SARS-CoV-2 and HCoV-OC43 Viruses
Puxeddu, M.; Donalisio, M.; Bugert, J. J.; Corona, A.; Cocomazzi, P.; Milani, M.; Hucke, F.; Arduino, I.; Esposito, F.; Moretti, P.; Ortore, M. G.; Nalli, M.; Manetto, S.; Mazzoccanti, G.; Bigogno, C.; Dondio, G.; Scio', P.; Coluccia, A.; Fracella, M.; Antonelli, G.; Lembo, D.; Tramontano, E.; Silvestri, R.; Mastrangelo, E.; La Regina, G. - 01a Articolo in rivista
paper: ACS INFECTIOUS DISEASES (Washington, DC : American Chemical Society, 2015-) pp. 3158-3175 - issn: 2373-8227 - wos: WOS:001284160100001 (2) - scopus: 2-s2.0-85200391860 (2)

11573/1727020 - 2024 - Development of N-(4-(1 H-Imidazol-1-yl)phenyl)-4-chlorobenzenesulfonamide, a Novel Potent Inhibitor of β-Catenin with Enhanced Antitumor Activity and Metabolic Stability
Puxeddu, Michela; Ling, Lele; Ripa, Silvia; D'ambrosio, Michele; Nalli, Marianna; Parisi, Anastasia; Scio', Pietro; Coluccia, Antonio; Granese, Arianna; Santelli, Martina; Masci, Domiziana; Cuřínová, Petra; Naro, Chiara; Sette, Claudio; Pastore, Arianna; Stornaiuolo, Mariano; Bigogno, Chiara; Dondio, Giulio; Di Magno, Laura; Canettieri, Gianluca; Liu, Te; Silvestri, Romano; La Regina, Giuseppe - 01a Articolo in rivista
paper: JOURNAL OF MEDICINAL CHEMISTRY (Washington DC : ACS Publications) pp. 20298-20314 - issn: 1520-4804 - wos: WOS:001350014100001 (2) - scopus: 2-s2.0-85208709914 (1)

11573/1753206 - 2024 - Non-Polio Enterovirus Inhibitors: Scaffolds, Targets, and Potency─What’s New?
Roux, Hugo Fernando Georges; Touret, Franck; Rathelot, Pascal; Scio', Pietro; Coluccia, Antonio; Vanelle, Patrice; Roche, Manon - 01a Articolo in rivista
paper: ACS INFECTIOUS DISEASES (Washington, DC : American Chemical Society, 2015-) pp. 21-46 - issn: 2373-8227 - wos: WOS:001382233700001 (0) - scopus: 2-s2.0-85213039140 (0)

11573/1715709 - 2024 - New Potent EV-A71 Antivirals Targeting Capsid
Roux, Hugo; Touret, Franck; Coluccia, Antonio; Khoumeri, Omar; Majdi, Chaimae; Scio, Pietro; Silvestri, Romano; Vanelle, Patrice; Manon Roche, And - 01a Articolo in rivista
paper: EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY (Editions Scientifique & Medical Elsevier:23 Rue Linois, F 75724 Paris Cedex 15 France:011 33 1 71724646, INTERNET: http://www.elsevier.fr, Fax: 011 33 1 71724664) pp. 1-18 - issn: 0223-5234 - wos: WOS:001286467500001 (1) - scopus: 2-s2.0-85199915542 (1)

11573/1720626 - 2024 - SAR Analysis of Novel Coxsackie virus A9 Capsid Binders
Tammaro, Chiara; Plavec, Zlatka; Myllymäki, Laura; Mitchell, Cristopher; Consalvi, Sara; Biava, Mariangela; Ciogli, Alessia; Domanska, Aušra; Leppilampi, Valtteri; Buckner, Cienna; Manetto, Simone; Sciò, Pietro; Coluccia, Antonio; Laajala, Mira; Dondio, Giulio M; Bigogno, Chiara; Marjomäki, Varpu; Butcher, Sarah J; Poce, Giovanna - 01a Articolo in rivista
paper: JOURNAL OF MEDICINAL CHEMISTRY (Washington, DC: American Chemical Society) pp. 17144-17161 - issn: 0022-2623 - wos: WOS:001315707100001 (0) - scopus: 2-s2.0-85205702382 (0)

11573/1680491 - 2023 - Targeting the Grb2 cSH3 domain: design, synthesis and biological evaluation of the first series of modulators
Bufano, Marianna; Puxeddu, Michela; Nalli, Marianna; La Regina, Giuseppe; Toto, Angelo; Liberati, Francesca Romana; Paone, Alessio; Cutruzzolà, Francesca; Masci, Domiziana; Bigogno, Chiara; Dondio, Giulio; Silvestri, Romano; Gianni, Stefano; Coluccia, Antonio - 01a Articolo in rivista
paper: BIOORGANIC CHEMISTRY (Academic Press Incorporated:6277 Sea Harbor Drive:Orlando, FL 32887:(800)543-9534, (407)345-4100, EMAIL: ap@acad.com, INTERNET: http://www.idealibrary.com, Fax: (407)352-3445) pp. 106607- - issn: 0045-2068 - wos: WOS:001007153500001 (3) - scopus: 2-s2.0-85159597372 (3)

11573/1667362 - 2023 - Toll-like receptor 4-dependent platelet-related thrombosis in SARS-CoV-2 infection
Carnevale, Roberto; Cammisotto, Vittoria; Bartimoccia, Simona; Nocella, Cristina; Castellani, Valentina; Bufano, Marianna; Loffredo, Lorenzo; Sciarretta, Sebastiano; Frati, Giacomo; Coluccia, Antonio; Silvestri, Romano; Ceccarelli, Giancarlo; Oliva, Alessandra; Venditti, Mario; Pugliese, Francesco; Maria Mastroianni, Claudio; Turriziani, Ombretta; Leopizzi, Martina; D'amati, Giulia; Pignatelli, Pasquale; Violi, Francesco - 01a Articolo in rivista
paper: CIRCULATION RESEARCH (Lippincott, Williams & Wilkins:530 Walnut Street:Philadelphia, PA 19106:(800)638-3030, (301)223-2300, EMAIL: orders@lww.com, INTERNET: http://www.lww.com, Fax: (301)223-2320, (301)223-2320 PRimo editore: Baltimore, Md. : Grune & Stratton, c1953-) pp. 290-305 - issn: 0009-7330 - wos: WOS:000924202600003 (27) - scopus: 2-s2.0-85147310768 (29)

11573/1738930 - 2023 - Drug design and synthesis of new anticancer agents
Mai, A.; Fioravanti, R.; Rotili, D.; Valente, S.; Zwergel, C.; Secci, D.; Chimenti, P.; Granese, A.; Guglielmi, P.; Silvestri, R.; Coluccia, A.; La Regina, G.; Nalli, M. - 04f Poster
conference: Highlighting the Research Activity of the Sapienza Faculty of Pharmacy and Medicine (Roma, Italy)
book: Abstract Book - ()

11573/1696179 - 2023 - 4-(3-Phenyl-4-(3,4,5-trimethoxybenzoyl)-1H-pyrrol-1-yl)benzenesulfonamide, a novel carbonic anhydrase and Wnt/β-Catenin signaling pathway dual-targeting inhibitor with potent activity against multidrug resistant cancer cells
Masci, Domiziana; Puxeddu, Michela; Di Magno, Laura; D'ambrosio, Michele; Parisi, Anastasia; Nalli, Marianna; Bai, Ruoli; Coluccia, Antonio; Sciò, Pietro; Orlando, Viviana; D'angelo, Sara; Biagioni, Stefano; Urbani, Andrea; Hamel, Ernest; Nocentini, Alessio; Filiberti, Serena; Turati, Marta; Ronca, Roberto; Kopecka, Joanna; Riganti, Chiara; Fionda, Cinzia; Bordone, Rosa; Della Rocca, Giorgia; Canettieri, Gianluca; Supuran, Claudiu T; Silvestri, Romano; La Regina, Giuseppe - 01a Articolo in rivista
paper: JOURNAL OF MEDICINAL CHEMISTRY (Washington DC : ACS Publications) pp. 14824-14842 - issn: 1520-4804 - wos: WOS:001096765200001 (9) - scopus: 2-s2.0-85176509722 (10)

11573/1684557 - 2023 - Novel N-(Heterocyclylphenyl)benzensulfonamide Sharing an Unreported Binding Site with T-Cell Factor 4 at the β-Catenin Armadillo Repeats Domain as an Anticancer Agent
Nalli, Marianna; Di Magno, Laura; Wen, Yichao; Liu, Xin; D’Ambrosio, Michele; Puxeddu, Michela; Parisi, Anastasia; Sebastiani, Jessica; Sorato, Andrea; Coluccia, Antonio; Ripa, Silvia; Di Pastena, Fiorella; Capelli, Davide; Montanari, Roberta; Masci, Domiziana; Urbani, Andrea; Naro, Chiara; Sette, Claudio; Orlando, Viviana; D’Angelo, Sara; Biagioni, Stefano; Bigogno, Chiara; Dondio, Giulio; Pastore, Arianna; Stornaiuolo, Mariano; Canettieri, Gianluca; Liu, Te; Silvestri, Romano; La Regina, Giuseppe - 01a Articolo in rivista
paper: ACS PHARMACOLOGY & TRANSLATIONAL SCIENCE (Washington DC: American Chemical Society) pp. 1087-1103 - issn: 2575-9108 - wos: WOS:001022871100001 (5) - scopus: 2-s2.0-85164931909 (3)

11573/1739037 - 2023 - New N-(heterocyclylphenyl)benzenesulfonamides as beta-catenin inhibitors
Parisi, A.; Nalli, M.; Coluccia, A.; Liu, T.; La Regina, G.; Silvestri, R. - 04f Poster
conference: XXVIII National Meeting on Medicinal Chemistry - 15th Young Medicinal Chemists' Symposium (Chieti, Italy)
book: Abstract Book - ()

11573/1645691 - 2022 - Exploring CCRL2 chemerin binding using accelerated molecular dynamics
Bufano, M.; Laffranchi, M.; Sozzani, S.; Raimondo, D.; Silvestri, R.; Coluccia, A. - 01a Articolo in rivista
paper: PROTEINS (John Wiley & Sons Incorporated:Customer Service, 111 River Street:Hoboken, NJ 07030:(800)225-5945, (201)748-6000, EMAIL: societyinfo@wiley.com, INTERNET: http://www.wiley.com, Fax: (212)748-6551) pp. 1-7 - issn: 0887-3585 - wos: WOS:000788507200001 (8) - scopus: 2-s2.0-85128889142 (8)

11573/1738918 - 2022 - Anticancer activity of RS4690, a new Dishevelled I inhibitor
Coluccia, A.; Bufano, M.; La Regina, G.; Puxeddu, M.; Silvestri, R. - 04f Poster
conference: STRATAGEM’s 5th Annual Meeting (Coimbra, Portugal)
book: Abstract Book - ()

11573/1616528 - 2022 - Anticancer activity of (S)-5-Chloro-3-((3,5-dimethylphenyl)sulfonyl)-N-(1-oxo-1-((pyridin-4-ylmethyl)amino)propan-2-yl)-1H-indole-2-carboxamide (RS4690), a new dishevelled 1 inhibitor
Coluccia, Antonio; Bufano, Marianna; La Regina, Giuseppe La; Puxeddu, Michela; Toto, Angelo; Paone, Alessio; Bouzidi, Amani; Musto, Giorgia; Badolati, Nadia; Orlando, Viviana; Biagioni, Stefano; Masci, Domiziana; Cantatore, Chiara; Cirilli, Roberto; Cutruzzolà, Francesca; Gianni, Stefano; Stornaiuolo, Mariano; Silvestri, Romano - 01a Articolo in rivista
paper: CANCERS (Basel: MDPI) pp. - - issn: 2072-6694 - wos: WOS:000773498900001 (8) - scopus: 2-s2.0-85131007159 (9)

11573/1660747 - 2022 - Discovery of novel human lactate dehydrogenase inhibitors. Structure-based virtual screening studies and biological assessment
Di Magno, L; Coluccia, A; Bufano, M; Ripa, S; La Regina, G; Nalli, M; Di Pastena, F; Canettieri, G; Silvestri, R; Frati, L - 01a Articolo in rivista
paper: EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY (Editions Scientifique & Medical Elsevier:23 Rue Linois, F 75724 Paris Cedex 15 France:011 33 1 71724646, INTERNET: http://www.elsevier.fr, Fax: 011 33 1 71724664) pp. 1-12 - issn: 0223-5234 - wos: WOS:000834164000003 (16) - scopus: 2-s2.0-85134696311 (15)

11573/1738926 - 2022 - Novel pyrrole derivatives as tubulin polymerization inhibitor agent capable of inducing ferroptosis in glioblastoma and ovarian cancer cells lines
Puxeddu, M.; La Regina, G.; Coluccia, A.; Nalli, M.; Silvestri, R. - 04f Poster
conference: Merck Young Chemists' Symposium (Rimini, Italy)
book: Abstract Book - ()

11573/1664745 - 2022 - Induction of ferroptosis in glioblastoma and ovarian cancers by a new pyrrole tubulin assembly inhibitor
Puxeddu, Michela; Wu, Jianchao; Bai, Ruoli; D’Ambrosio, Michele; Nalli, Marianna; Coluccia, Antonio; Manetto, Simone; Ciogli, Alessia; Masci, Domiziana; Urbani, Andrea; Fionda, Cinzia; Coni, Sonia; Bordone, Rosa; Canettieri, Gianluca; Bigogno, Chiara; Dondio, Giulio; Hamel, Ernest; Liu, Te; Silvestri, Romano; La Regina, Giuseppe - 01a Articolo in rivista
paper: JOURNAL OF MEDICINAL CHEMISTRY (Washington, DC: American Chemical Society) pp. 15805-15818 - issn: 0022-2623 - wos: WOS:000888017600001 (21) - scopus: 2-s2.0-85142634063 (16)

11573/1579282 - 2021 - Targeting PDZ domains as potential treatment for viral infections, neurodegeneration and cancer
Nardella, Caterina; Visconti, Lorenzo; Malagrinò, Francesca; Pagano, Livia; Bufano, Marianna; Nalli, Marianna; Coluccia, Antonio; La Regina, Giuseppe; Silvestri, Romano; Gianni, Stefano; Toto, Angelo - 01a Articolo in rivista
paper: BIOLOGY DIRECT (London: BioMed Central) pp. - - issn: 1745-6150 - wos: WOS:000706722300001 (19) - scopus: 2-s2.0-85117321017 (19)

11573/1738698 - 2021 - Inhibition of ZIKA virus replication by novel inhibitors of NS2B/NS3 complex
Pecora, D.; La Regina, G.; Coluccia, A.; Nalli, M.; Lee, J. -C.; Silvestri, R. - 04f Poster
conference: Paul Ehrlich Euro-PhD Network Virtual Meeting 2021 (Online meeting)
book: Book of Abstracts - ()

11573/1738711 - 2021 - A new potential target in oncological therapy: the interaction between Gab2 with SH3-domain of Gbr2
Puxeddu, M.; Coluccia, A.; La Regina, G.; Gianni, S.; Silvestri, R - 04f Poster
conference: XXVII Congresso Nazionale della Società Chimica Italiana (Online meeting)
book: Abstract Book - ()

11573/1738722 - 2021 - Discovery of novel pyrrole derivatives as anti-glioblastoma and anti-chronic myeloid leukemia agents
Puxeddu, M.; La Regina, G.; Coluccia, A.; Hamel, E.; Liu, T.; Silvestri, R. - 04f Poster
conference: Merck Young Chemists’ Symposium (Rimini, Italia)
book: Abstract Book - ()

11573/1738007 - 2021 - New pyrroles derivatives as anti-glioblastoma and anti-chronic myeloid leukemia agents
Puxeddu, M.; Sebastiani, J.; Coluccia, A.; Bufano, M.; Hamel, E.; Liu, T.; Silvestri, R.; La Regina, G. - 04b Atto di convegno in volume
conference: XXVII Congresso Nazionale della Società Chimica Italiana (Online meeting)
book: XXVII congresso nazionale della Società Chimica Italiana - ()

11573/1554523 - 2021 - Discovery of pyrrole derivatives for the treatment of glioblastoma and chronic myeloid leukemia
Puxeddu, M.; Shen, H.; Bai, R.; Coluccia, A.; Bufano, M.; Nalli, M.; Sebastiani, J.; Brancaccio, D.; Da Pozzo, E.; Tremolanti, C.; Martini, C.; Orlando, V.; Biagioni, S.; Sinicropi, M. S.; Ceramella, J.; Iacopetta, D.; Coluccia, A. M. L.; Hamel, E.; Liu, T.; Silvestri, R.; La Regina, G. - 01a Articolo in rivista
paper: EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY (Editions Scientifique & Medical Elsevier:23 Rue Linois, F 75724 Paris Cedex 15 France:011 33 1 71724646, INTERNET: http://www.elsevier.fr, Fax: 011 33 1 71724664) pp. 1-18 - issn: 0223-5234 - wos: WOS:000661282500029 (21) - scopus: 2-s2.0-85106600720 (20)

11573/1738709 - 2021 - New pyrrole derivatives for the treatment of glioblastoma and chronic myeloid leukemia
Sebastiani, J.; Coluccia, A.; Hamel, H.; Liu, T.; Silvestri, R.; La Regina, G. - 04f Poster
conference: European School of Medicinal Chemistry ESMEC, 44th Advanced Course of Medicinal Chemistry and Seminar for PhD students (Online meeting)
book: Abstract Book - ()

11573/1738712 - 2021 - Novel sulfonamide inhibitors of beta-catenin signaling as anticancer agents
Sebastiani, J.; Coluccia, A.; La Regina, G.; Canettieri, G.; Silvestri, R. - 04f Poster
conference: XXVII Congresso Nazionale della Società Chimica Italiana (Online meeting)
book: Abstract Book - ()

11573/1738694 - 2021 - A new potential target in oncological therapy: the interaction between Gab2 with SH3-domain of GBR2
Sebastiani, J.; Coluccia, A.; La Regina, G.; Gianni, S.; Silvestri, R. - 04f Poster
conference: 13th Young Medicinal Chemist Symposium (Nuove Prospettive in Chimica Farmaceutica, NPCF13) (Online meeting)
book: A - ()

11573/1738715 - 2021 - New pyrrole derivatives for the treatment of glioblastoma and chronic myeloid leukemia
Sebastiani, J.; Puxeddu, M.; Coluccia, A.; Bufano, M.; Hamel, E.; Liu, T.; Silvestri, R.; La Regina, G. - 04f Poster
conference: 2nd Autumn Meeting for Young Chemists in Biomedical Sciences (Online meeting)
book: Abstract Book - ()

11573/1436420 - 2020 - Modeling Epac1 interactions with the allosteric inhibitor AM-001 by co-solvent molecular dynamics
Bufano, M.; Laudette, M.; Blondeau, J. -P.; Lezoualc'h, F.; Nalli, M.; Silvestri, R.; Brancale, A.; Coluccia, A. - 01a Articolo in rivista
paper: JOURNAL OF COMPUTER-AIDED MOLECULAR DESIGN (-SPRINGER, VAN GODEWIJCKSTRAAT 30, DORDRECHT, NETHERLANDS, 3311 GZ -Kluwer Academic Publishers:Journals Department, PO Box 322, 3300 AH Dordrecht Netherlands:011 31 78 6576050, EMAIL: frontoffice@wkap.nl, kluweronline@wkap.nl, INTERNET: http://www.kluwerlaw.com, Fax: 011 31 78 6576254) pp. - - issn: 0920-654X - wos: WOS:000551348400001 (3) - scopus: 2-s2.0-85088437648 (2)

11573/1436287 - 2020 - Discovery of Zika virus NS2B/NS3 inhibitors that prevent mice from fife-threatening infection and brain damage
Coluccia, A.; Puxeddu, M.; Nalli, M.; Wei, C. K.; Wu, Y. H.; Mastrangelo, E.; Elamin, T.; Tarantino, D.; Bugert, J. J.; Schreiner, B.; Nolte, J.; Schwarze, F.; La Regina, G.; Lee, J. C.; Silvestri, R. - 01a Articolo in rivista
paper: ACS MEDICINAL CHEMISTRY LETTERS (USA: ACS Publications) pp. 1869-1874 - issn: 1948-5875 - wos: WOS:000580567800013 (22) - scopus: 2-s2.0-85089122411 (22)

11573/1436346 - 2020 - Enzymatic kinetic resolution of desmethylphosphinothricin indicates that phosphinic group is a bioisostere of carboxyl group
De Biase, Daniela; Cappadocio, Francesca; Pennacchietti, Eugenia; Giovannercole, Fabio; Coluccia, Antonio; Vepsäläinen, Jouko; Khomutov, Alex - 01a Articolo in rivista
paper: COMMUNICATIONS CHEMISTRY ([London]: [Macmillan Publishers Ltd part of Springer Nature], 2018-) pp. - - issn: 2399-3669 - wos: WOS:000619266000001 (11) - scopus: 2-s2.0-85090780766 (12)

11573/1451071 - 2020 - Sulfonamide inhibitors of beta-catenin signaling as anticancer agents with different output on c-Myc
Di Magno, Laura; Di Pastena, Fiorella; Puxeddu, Michela; La Regina, Giuseppe; Coluccia, Antonio; Ciogli, Alessia; Manetto, Simone; Maroder, Marella; Canettieri, Gianluca; Silvestri, Romano; Nalli, Marianna - 01a Articolo in rivista
paper: CHEMMEDCHEM (Weinheim : Wiley-VCH-Verl..) pp. 2264-2268 - issn: 1860-7179 - wos: WOS:000577594900001 (8) - scopus: 2-s2.0-85092511066 (8)

11573/1456152 - 2020 - Targeting the interaction between the SH3 domain of Grb2 and Gab2
Malagrinò, Francesca; Coluccia, Antonio; Bufano, Marianna; La Regina, Giuseppe; Puxeddu, Michela; Toto, Angelo; Visconti, Lorenzo; Paone, Alessio; Magnifico, Maria Chiara; Troilo, Francesca; Cutruzzolà, Francesca; Silvestri, Romano; Gianni, Stefano - 01a Articolo in rivista
paper: CELLS (Basel: mdpi-Molecular Diversity Preservation International) pp. 2435- - issn: 2073-4409 - wos: WOS:000592940700001 (9) - scopus: 2-s2.0-85096028884 (9)

11573/1436323 - 2020 - New indolylarylsulfone non-nucleoside reverse transcriptase inhibitors show low nanomolar inhibition of single and double HIV-1 mutant strains
Nalli, M.; Armijos Rivera, J. I.; Masci, D.; Coluccia, A.; Badia, R.; Riveira-Muñoz, E.; Brambilla, A.; Cinquina, E.; Turriziani, O.; Falasca, F.; Catalano, M.; Limatola, C.; Esté, J. A.; Maga, G.; Silvestri, R.; Crespan, E.; La Regina, G. - 01a Articolo in rivista
paper: EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY (Editions Scientifique & Medical Elsevier:23 Rue Linois, F 75724 Paris Cedex 15 France:011 33 1 71724646, INTERNET: http://www.elsevier.fr, Fax: 011 33 1 71724664) pp. - - issn: 0223-5234 - wos: WOS:000600384300005 (16) - scopus: 2-s2.0-85090028457 (16)

11573/1338485 - 2020 - Structure-activity relationship studies and in vitro and in vivo anticancer activity of novel 3-aroyl-1,4-diarylpyrroles against solid tumors and hematological malignancies
Puxeddu, M.; Shen, H.; Bai, R.; Coluccia, A.; Nalli, M.; Mazzoccoli, C.; Da Pozzo, E.; Cavallini, C.; Martini, C.; Orlando, V.; Biagioni, S.; Mazzoni, C.; Coluccia, A. M. L.; Hamel, E.; Liu, T.; Silvestri, R.; La Regina, G. - 01a Articolo in rivista
paper: EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY (Editions Scientifique & Medical Elsevier:23 Rue Linois, F 75724 Paris Cedex 15 France:011 33 1 71724646, INTERNET: http://www.elsevier.fr, Fax: 011 33 1 71724664) pp. - - issn: 0223-5234 - wos: WOS:000503099900046 (10) - scopus: 2-s2.0-85075503012 (11)

11573/1738609 - 2020 - Novel 3-aroyl-1,4-diarylpyrroles against solid tumors and hematological malignancies
Puxeddu, Michela; Coluccia, Antonio; Nalli, Marianna; Hamel, Ernest; La Regina, Giuseppe; Silvestri, Romano - 04f Poster
conference: Italian Young Medicinal Chemistry Virtual Meeting (I-YMC-VMEET) (Online meeting)
book: Abstract Book - ()

11573/1738612 - 2020 - New 1,1’-Biphenyl-4-sulfonamides as Potent and Selective Human Carbonic Anhydrase Inhibitors
Puxeddu, Michela; La Regina, Giuseppe; Coluccia, Antonio; Silvestri, Romano - 04f Poster
conference: WG2 Meeting and International Online Symposium on “Synthesis and nanodelivery strategies for new therapeutic tools against Multidrug Resistant Tumours” (Online meeting)
book: Abstract Book - ()

11573/1452337 - 2020 - Mutational analysis of the essential lipopolysaccharide-transport protein LptH of Pseudomonas aeruginosa to uncover critical oligomerization sites
Scala, R.; Di Matteo, A.; Coluccia, A.; Lo Sciuto, A.; Federici, L.; Travaglini-Allocatelli, C.; Visca, P.; Silvestri, R.; Imperi, F. - 01a Articolo in rivista
paper: SCIENTIFIC REPORTS (London: Springer Nature London: Nature Publishing Group) pp. 11276- - issn: 2045-2322 - wos: WOS:000548559600037 (5) - scopus: 2-s2.0-85087717252 (7)

11573/1282534 - 2019 - Nox2-mediated platelet activation by glycoprotein (GP) VI: Effect of rivaroxaban alone and in combination with aspirin
Cammisotto, Vittoria; Carnevale, Roberto; Nocella, Cristina; Stefanini, Lucia; Bartimoccia, Simona; Coluccia, Antonio; Silvestri, Romano; Pignatelli, Pasquale; Pastori, Daniele; Violi, Francesco - 01a Articolo in rivista
paper: BIOCHEMICAL PHARMACOLOGY (-Oxford, United Kingdom: Elsevier Science Limited -London ; New York : Pergamon Press, 1958-) pp. 111-118 - issn: 0006-2952 - wos: WOS:000466060000011 (19) - scopus: 2-s2.0-85061548638 (20)

11573/1223718 - 2019 - Drug design and synthesis of first in class PDZ1 targeting NHERF1 inhibitors as anticancer agents
Coluccia, A.; La Regina, G.; Naccarato, V.; Nalli, M.; Orlando, V.; Biagioni, S.; De Angelis, M. L.; Baiocchi, M.; Gautier, C.; Gianni, S.; Di Pastena, F.; Di Magno, L.; Canettieri, G.; Coluccia, A. M. L.; Silvestri, R. - 01a Articolo in rivista
paper: ACS MEDICINAL CHEMISTRY LETTERS (USA: ACS Publications) pp. 499-503 - issn: 1948-5875 - wos: WOS:000464767700019 (14) - scopus: 2-s2.0-85064264813 (15)

11573/1342028 - 2019 - Evaluation of pharmacophoric models at colchicine binding site by ROC curves
Esposito, Chiara; Bufano, Marianna; Coluccia, Antonio - 04f Poster
conference: 6th computational driven drugs discovery, CDDD Meeting 2019 (Rome; Italy)
book: Nessuna - ()

11573/1223723 - 2019 - Towards modern anticancer agents that interact with tubulin
La Regina, G.; Coluccia, A.; Naccarato, V.; Silvestri, R. - 01a Articolo in rivista
paper: EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES (Amsterdam Netherlands: Elsevier BV) pp. 58-68 - issn: 0928-0987 - wos: WOS:000460399800006 (41) - scopus: 2-s2.0-85061343987 (43)

11573/1338512 - 2019 - Design, synthesis and biological evaluation of PDZ1 targeting NHERF1 inhibitors as anticancer agents
La Regina, G.; Naccarato, V.; Masci, D.; Puxeddu, M.; Bufano, M.; Nalli, M.; Coluccia, A.; Orlando, V.; Canettieri, G.; Gianni, S.; Silvestri, R. - 04f Poster
conference: XXVI National Meeting in Medicinal Chemistry - XII Young Medicinal Chemists’ Symposium (Milano, Italy)
book: Abstract Book - ()

11573/1338507 - 2019 - Small molecule inhibitors of kdm5 histone demethylases increase the radiosensitivity of breast cancer cells overexpressing JARID1B
La Regina, G.; Naccarato, V.; Masci, D.; Puxeddu, M.; Nalli, M.; Coluccia, A.; Negri, R.; Silvestri, R. - 04f Poster
conference: XXVI National Meeting in Medicinal Chemistry - XII Young Medicinal Chemists’ Symposium (Milano)
book: Abstract Book - ()

11573/1278679 - 2019 - New anti-cancer agents through an interaction with tubulin
La Regina, G; Coluccia, A; Naccarato, V; Silvestri, R. - 04f Poster
conference: New Diagnostic and Therapeutic Tools against Multidrug-Resistant Tumours - First Working-Group Meeting (Torino (TO))
book: Abstract Book - ()

11573/1278540 - 2019 - First in class pdz1 targeting NHERF1 inhibitors as anticancer agents
La Regina, Giuseppe; Naccarato, Valentina; Puxeddu, Michela; Bufano, Marianna; Nalli, Marianna; Coluccia, Antonio; Silvestri, Romano - 04f Poster
conference: 12th European Workshop in Drug Design (Siena)
book: Abstract Book - ()

11573/1338740 - 2019 - Identification of a pharmacological inhibitor of Epac1 that protects the heart against acute and chronic models of cardiac stress
Laudette, Marion; Coluccia, Antonio; Sainte-Marie, Yannis; Solari, Andrea; Fazal, Loubina; Sicard, Pierre; Silvestri, Romano; Mialet-Perez, Jeanne; Pons, Sandrine; Ghaleh, Bijan; Blondeau, Jean-Paul; Frank Lezoualc’H, And - 01a Articolo in rivista
paper: CARDIOVASCULAR RESEARCH (Oxford: Oxford University Press Amsterdam: Elsevier London: British Medical Association, 1967-) pp. 1766-1777 - issn: 0008-6363 - wos: WOS:000491246600015 (32) - scopus: 2-s2.0-85072535959 (33)

11573/1284052 - 2019 - Switching on the activity of 1,5-diaryl-pyrrole derivatives against drug-resistant ESKAPE bacteria: structure-activity relationships and mode of action studies
Masci, D.; Hind, C.; Islam, M. K.; Toscani, A.; Clifford, M.; Coluccia, A.; Conforti, Irene; Touitou, M.; Memdouh, S.; Wei, X.; La Regina, G.; Silvestri, R.; Sutton, J. M.; Castagnolo, D. - 01a Articolo in rivista
paper: EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY (Editions Scientifique & Medical Elsevier:23 Rue Linois, F 75724 Paris Cedex 15 France:011 33 1 71724646, INTERNET: http://www.elsevier.fr, Fax: 011 33 1 71724664) pp. 500-514 - issn: 0223-5234 - wos: WOS:000480664100037 (28) - scopus: 2-s2.0-85067210411 (30)

11573/1266997 - 2019 - Small molecule inhibitors of KDM5 histone demethylases increase the radiosensitivity of breast cancer cells overexpressing Jarid1b
Pippa, S; Mannironi, C; Licursi, V; Bombardi, Luca; Colotti, G; Cundari, E; Mollica, A; Coluccia, A; Naccarato, V; La Regina, G; Silvestri, R; Negri, R - 01a Articolo in rivista
paper: MOLECULES (Basel: MDPI Berlin: Springer, 1996-) pp. - - issn: 1420-3049 - wos: WOS:000469518100098 (25) - scopus: 2-s2.0-85065652898 (26)

11573/1174760 - 2018 - Structure-based drug design of potent pyrazole derivatives against Rhinovirus replication
Da Costa, L.; Scheers, E.; Coluccia, A.; Casulli, A.; Roche, M.; Di Giorgio, C.; Neyts, J.; Terme, T.; Cirilli, R.; La Regina, G.; Silvestri, R.; Mirabelli, C.; Vanelle, P. - 01a Articolo in rivista
paper: JOURNAL OF MEDICINAL CHEMISTRY (Washington, DC: American Chemical Society) pp. 8402-8416 - issn: 0022-2623 - wos: WOS:000446142000022 (38) - scopus: 2-s2.0-85053181101 (43)

11573/1117718 - 2018 - New 6- and 7-heterocyclyl-1H-indole derivatives as potent tubulin assembly and cancer cell growth inhibitors
La Regina, G.; Naccarato, V.; Coluccia, A.; Hamel, E.; Silvestri, R. - 04f Poster
conference: Seventh European Workshop in Drug Synthesis (Siena, Italy)
book: Abstract Book - ()

11573/1117651 - 2018 - New 6- and 7-heterocyclyl-1H-indole derivatives as potent tubulin assembly and cancer cell growth inhibitors
La Regina, Giuseppe; Bai, Ruoli; Coluccia, Antonio; Naccarato, Valentina; Famiglini, Valeria; Nalli, Marianna; Masci, Domiziana; Verrico, Annalisa; Rovella, Paola; Mazzoccoli, Carmela; Da Pozzo, Eleonora; Cavallini, Chiara; Martini, Claudia; Vultaggio, Stefania; Dondio, Giulio; Varasi, Mario; Mercurio, Ciro; Hamel, Ernest; Lavia, Patrizia; Silvestri, Romano - 01a Articolo in rivista
paper: EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY (Editions Scientifique & Medical Elsevier:23 Rue Linois, F 75724 Paris Cedex 15 France:011 33 1 71724646, INTERNET: http://www.elsevier.fr, Fax: 011 33 1 71724664) pp. 283-297 - issn: 0223-5234 - wos: WOS:000435048900023 (35) - scopus: 2-s2.0-85046738606 (38)

11573/1170129 - 2018 - Treating chronic myeloid leukemia by inhibition of tubulin polymerization
La Regina, Giuseppe; Coluccia, Antonio; Naccarato, Valentina; Maria Luce Coluccia, Addolorata; Hamel, Ernest; Novellino, Ettore; Silvestri, Romano - 04b Atto di convegno in volume
conference: Italian-Spanish-Portuguese Joint Meeting in Medicinal Chemistry (Palermo)
book: Book of Abstracts - ()

11573/1118125 - 2018 - Indolylarylsulfones with potent anti-HIV-1 activity
Masci, Domiziana; La Regina, Giuseppe; Coluccia, Antonio; Brancale, Andrea; Esté, José A.; Silvestri, Romano - 04f Poster
conference: 31st International Conference on Antiviral Research (Porto, Portogallo)
book: Program and Abstracts - ()

11573/1286679 - 2018 - Indolylarylsulfones as novel potent anti-HIV-1 agents
Masci, Domiziana; La Regina, Giuseppe; Coluccia, Antonio; Brancale, Andrea; Esté, José A.; Silvestri, Romano - 04d Abstract in atti di convegno
conference: 9th Biology and Molecular Medicine PhD School Symposium (BeMM) (Roma)
book: Book of Abstract - ()

11573/1071891 - 2018 - β-catenin knockdown promotes nherf1-mediated survival of colorectal cancer cells: implications for a double-targeted therapy
Saponaro, Concetta; Sergio, Sara; Coluccia, Antonio; De Luca, Maria; La Regina, Giuseppe; Mologni, Luca; Famiglini, Valeria; Naccarato, Valentina; Bonetti, Daniela; Gautier, Candice Natacha Anna; Gianni, Stefano; Vergara, Daniele; Salzet, Michel; Fournier, Isabelle; Bucci, Cecilia; Silvestri, Romano; Gambacorti Passerini, Carlo; Maffia, Michele; Maria Luce Coluccia, Addolorata - 01a Articolo in rivista
paper: ONCOGENE (Macmillan Magazines Limited:Porters South Crinian Street, London N1 9XW United Kingdom:011 44 207 8334000, 011 44 171 8434982, Fax: 011 44 207 812358) pp. 3301-3316 - issn: 0950-9232 - wos: WOS:000435526600009 (19) - scopus: 2-s2.0-85044095990 (22)

11573/1033464 - 2017 - Heterocyclic pharmacochemistry of new rhinovirus antiviral agents: a combined computational and experimental study
Da Costa, Laurene; Scheers, Els; Coluccia, Antonio; Rosetti, Alessia; Roche, Manon; Neyts, Johan; Terme, Thierry; Cirilli, Roberto; Mirabelli, Carmen; Silvestri, Romano; Vanelle, Patrice - 01a Articolo in rivista
paper: EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY (Editions Scientifique & Medical Elsevier:23 Rue Linois, F 75724 Paris Cedex 15 France:011 33 1 71724646, INTERNET: http://www.elsevier.fr, Fax: 011 33 1 71724664) pp. 528-541 - issn: 0223-5234 - wos: WOS:000414620000037 (11) - scopus: 2-s2.0-85030546760 (15)

11573/935705 - 2017 - Mitotic cell death induction by targeting the mitotic spindle with tubulin-inhibitory indole derivative molecules
Di Cesare, Erica; Verrico, Annalisa; Miele, Andrea; Giubettini, Maria; Rovella, Paola; Coluccia, Antonio; Famiglini, Valeria; La Regina, Giuseppe; Cundari, Enrico; Silvestri, Romano; Lavia, Patrizia - 01a Articolo in rivista
paper: ONCOTARGET (Albany, N.Y. : Impact Journals) pp. 19738-19759 - issn: 1949-2553 - wos: WOS:000396879200088 (21) - scopus: 2-s2.0-85015806343 (22)

11573/1033459 - 2017 - New inhibitors of Dengue and Zika virus protease
Famiglini, Valeria; La Regina, Giuseppe; Coluccia, Antonio; Lee, Jin-Ching; Silvestri, Romano - 04f Poster
conference: XXVI Congresso Nazionale della Società Chimica Italiana (Paestum (SA))
book: Programma del XXVI Congresso Nazionale della Società Chimica Italiana - ()

11573/1284150 - 2017 - Drug design and synthesis of new indolylarylsulfones as HIV-1 non-nucleoside reverse transcriptase inhibitors
Famiglini, Valeria; La Regina, Giuseppe; Coluccia, Antonio; Masci, Domiziana; Badia, Roger; Esté, José A.; Crespan, Emmanuele; Maga, Giovanni - 04d Abstract in atti di convegno
conference: 30th International Conference on Antiviral Research (Atlanta, Stati Uniti)
book: Program and Abstracts - ()

11573/1014226 - 2017 - Chiral indolylarylsulfone non-nucleoside reverse transcriptase inhibitors as new potent and broad spectrum anti-HIV-1 agents
Famiglini, Valeria; La Regina, Giuseppe; Coluccia, Antonio; Masci, Domiziana; Brancale, Andrea; Badia, Roger; Riveira Muã±Oz, Eva; Estã©, Josã© A.; Crespan, Emmanuele; Brambilla, Alessandro; Maga, Giovanni; Catalano, Myriam; Limatola, Cristina; Formica, Francesca Romana; Cirilli, Roberto; Novellino, Ettore; Silvestri, Romano - 01a Articolo in rivista
paper: JOURNAL OF MEDICINAL CHEMISTRY (Washington, DC: American Chemical Society) pp. 6528-6547 - issn: 0022-2623 - wos: WOS:000407656700004 (22) - scopus: 2-s2.0-85027261384 (23)

11573/954246 - 2017 - 3-Aroyl-1,4-diarylpyrroles inhibit chronic myeloid leukemia cell growth through an interaction with tubulin
La Regina, Giuseppe; Bai, R.; Coluccia, Antonio; Famiglini, Valeria; Passacantilli, Sara; Naccarato, Valentina; Ortar, Giorgio; Mazzoccoli, Carmela; Ruggieri, V.; Agriesti, F.; Piccoli, C.; Tataranni, T.; Nalli, Marianna; Brancale, A.; Vultaggio, S.; Mercurio, C.; Varasi, M.; Saponaro, C.; Sergio, S.; Maffia, M.; Coluccia, A. M. L.; Hamel, E.; Silvestri, Romano - 01a Articolo in rivista
paper: ACS MEDICINAL CHEMISTRY LETTERS (USA: ACS Publications) pp. 521-526 - issn: 1948-5875 - wos: WOS:000401402900010 (12) - scopus: 2-s2.0-85018898332 (11)

11573/1033450 - 2017 - Inhibition of Dengue virus by novel inhibitors of RNA-dependent RNA polymerase and protease activities
La Regina, Giuseppe; Famiglini, Valeria; Masci, Domiziana; Coluccia, Antonio; Lee, Jin-Ching; Hiscott, John; Silvestri, Romano - 04f Poster
conference: 10th Joint Meeting on Medicinal Chemistry (Dubrovnik, Croazia)
book: Abstract Book - ()

11573/1284136 - 2017 - Inhibition of dengue virus by novel inhibitors of RNA-dependent RNA polymerase and protease activity
La Regina, Giuseppe; Famiglini, Valeria; Naccarato, Valentina; Coluccia, Antonio; Hiscott, John; Lee, Jin-Ching - 04d Abstract in atti di convegno
conference: 30th International Conference on Antiviral Research (Atlanta, Stati Uniti)
book: Program and Abstracts - ()

11573/1033456 - 2017 - 3-Aroyl-1,4-diarylpyrroles inhibit chronic myeloid leukemia cell growth through an interaction with tubulin
La Regina, Giuseppe; Naccarato, Valentina; Coluccia, Antonio; Maria Luce Coluccia, Addolorata; Hamel, Ernest; Silvestri, Romano - 04f Poster
conference: 10th Joint Meeting on Medicinal Chemistry (Dubrovnik, Croazia)
book: Abstract Book - ()

11573/1033458 - 2017 - Drug design and synthesis of new indolylarylsulfones as HIV-1 non-nucleoside reverse transcriptase inhibitors
Masci, Domiziana; La Regina, Giuseppe; Famiglini, Valeria; Coluccia, Antonio; Brancale, Andrea; Esté, José A.; Silvestri, Romano - 04f Poster
conference: XXVI Congresso Nazionale della Società Chimica Italiana (Paestum (SA))
book: Programma del XXVI Congresso Nazionale della Società Chimica Italiana - ()

11573/1033457 - 2017 - New pyrrole inhibitors of chronic myeloid leukemia cell growth
Naccarato, Valentina; La Regina, Giuseppe; Coluccia, Antonio; Maria Luce Coluccia, Addolorata; Hamel, Hernest; Silvestri, Romano - 04f Poster
conference: XXVI Congresso Nazionale della Società Chimica Italiana (Paestum (SA))
book: Programma del XXVI Congresso Nazionale della Società Chimica Italiana - ()

11573/1011030 - 2017 - New pyridine derivatives as inhibitors of acetylcholinesterase and amyloid aggregation
Pandolfi, Fabiana; De Vita, Daniela; Bortolami, Martina; Coluccia, Antonio; Di Santo, Roberto; Costi, Roberta; Andrisano, Vincenza; Alabiso, Francesco; Bergamini, Christian; Fato, Romana; Bartolini, Manuela; Scipione, Luigi - 01a Articolo in rivista
paper: EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY (Editions Scientifique & Medical Elsevier:23 Rue Linois, F 75724 Paris Cedex 15 France:011 33 1 71724646, INTERNET: http://www.elsevier.fr, Fax: 011 33 1 71724664) pp. 197-210 - issn: 0223-5234 - wos: WOS:000417962900018 (34) - scopus: 2-s2.0-85030860178 (38)

11573/1033449 - 2017 - Drug design and synthesis of new indolylarylsulfones as HIV-1 non-nucleoside reverse transcriptase inhibitors
Passacantilli, Sara; Famiglini, Valeria; La Regina, Giuseppe; Coluccia, Antonio; Masci, Domiziana; Esté, José A.; Maga, Giovanni; Silvestri, Romano - 04f Poster
conference: 10th Joint Meeting on Medicinal Chemistry (Dubrovnik, Croazia)
book: Book of Abstracts - ()

11573/1025425 - 2017 - Inhibition of dengue virus replication by novel inhibitors of RNA-dependent RNA polymerase and protease activities
Pelliccia, S.; Wub, Y. H.; Coluccia, A.; La Regina, G.; Tseng, C. K.; Famiglini, V.; Masci, D.; Hiscott, J.; Lee, J. C.; Silvestri, R. - 01a Articolo in rivista
paper: JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY (Taylor & Francis Limited:Rankine Road, Basingstoke RG24 8PR United Kingdom:011 44 1256 813035, EMAIL: madeline.sims@tandf.co.uk, info@tandf.co.uk, INTERNET: http://www.tandf.co.uk, Fax: 011 44 1256 330245) pp. 1091-1101 - issn: 1475-6366 - wos: WOS:000408991900004 (33) - scopus: 2-s2.0-85026861941 (34)

11573/888612 - 2016 - Structural biology in antiviral drug discovery
Bassetto, Marcella; Massarotti, Alberto; Coluccia, Antonio; Brancale, Andrea - 01a Articolo in rivista
paper: CURRENT OPINION IN PHARMACOLOGY (Elsevier BV:PO Box 211, 1000 AE Amsterdam Netherlands:011 31 20 4853757, 011 31 20 4853642, 011 31 20 4853641, EMAIL: nlinfo-f@elsevier.nl, INTERNET: http://www.elsevier.nl, Fax: 011 31 20 4853598) pp. 116-130 - issn: 1471-4892 - wos: WOS:000386861200017 (9) - scopus: 2-s2.0-84984999122 (12)

11573/907866 - 2016 - Structure-based virtual screening to get new scaffold inhibitors of the Ser/Thr protein kinase PknB from Mycobacterium tuberculosis
Coluccia, Antonio; La Regina, Giuseppe; Barilone, Nathalie; Lisa, María Natalia; Brancale, Andrea; André Leroux, Gwenaëlle; Alzari, Pedro M.; Silvestri, Romano - 01a Articolo in rivista
paper: LETTERS IN DRUG DESIGN & DISCOVERY (Bentham Science Publishers Ltd) pp. 1012-1018 - issn: 1570-1808 - wos: WOS:000389464700004 (5) - scopus: 2-s2.0-84995937420 (5)

11573/897502 - 2016 - New inhibitors of indoleamine 2,3-dioxygenase 1: molecular modeling studies, synthesis, and biological evaluation
Coluccia, Antonio; Passacantilli, Sara; Famiglini, Valeria; Sabatino, Manuela; Patsilinakos, Alexandros; Ragno, Rino; Mazzoccoli, Carmela; Sisinni, L.; Okuno, A.; Takikawa, O.; Silvestri, Romano; La Regina, Giuseppe - 01a Articolo in rivista
paper: JOURNAL OF MEDICINAL CHEMISTRY (Washington, DC: American Chemical Society) pp. 9760-9773 - issn: 0022-2623 - wos: WOS:000387737600010 (35) - scopus: 2-s2.0-84994853619 (38)

11573/872535 - 2016 - VP1 crystal structure-guided exploration and optimization of 4,5-dimethoxybenzene-based inhibitors of rhinovirus 14 infection
Da Costa, Laurène; Roche, Manon; Scheers, Els; Coluccia, Antonio; Neyts, Johan; Terme, Thierry; Leyssen, Pieter; Silvestri, Romano; Vanelle, Patrice - 01a Articolo in rivista
paper: EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY (Editions Scientifique & Medical Elsevier:23 Rue Linois, F 75724 Paris Cedex 15 France:011 33 1 71724646, INTERNET: http://www.elsevier.fr, Fax: 011 33 1 71724664) pp. 453-462 - issn: 0223-5234 - wos: WOS:000375360800039 (7) - scopus: 2-s2.0-84962663541 (9)

11573/887652 - 2016 - New Inhibitors of Dengue Virus Replication
Famiglini, Valeria; Pelliccia, Sveva; La Regina, Giuseppe; Coluccia, Antonio; Lee, J. C.; Silvestri, Romano - 04a Atto di comunicazione a congresso
conference: XXIV National Meeting on Medicinal Chemistry (Perugia)
book: Abstract eBook - ()

11573/887653 - 2016 - New Inhibitors of indoleamine 2,3-dioxygenase 1: molecular modelling studies, synthesis and biological evaluation
La Regina, Giuseppe; Coluccia, Antonio; Famiglini, Valeria; Passacantilli, Sara; Mazzoccoli, Carmela; Takikawa, O.; Silvestri, Romano - 04f Poster
conference: XXIV National Meeting on Medicinal Chemistry (Perugia, Italy)
book: Abstract Book - ()

11573/872545 - 2016 - An in-silico approach aimed to clarify the role of Y181C and K103N HIV-1 reverse transcriptase mutations versus Indole Aryl Sulphones
Massarotti, Alberto; Coluccia, Antonio - 01a Articolo in rivista
paper: JOURNAL OF MOLECULAR GRAPHICS & MODELLING (Elsevier Science Incorporated / NY Journals:Madison Square Station, PO Box 882:New York, NY 10159:(212)633-3730, EMAIL: usinfo-f@elsevier.com, INTERNET: http://www.elsevier.com, Fax: (212)633-3680) pp. 49-56 - issn: 1093-3263 - wos: WOS:000369204800007 (4) - scopus: 2-s2.0-84948662815 (6)

11573/880563 - 2016 - Bicyclic γ-amino acids as inhibitors of γ-aminobutyrate aminotransferase
Pinto, Andrea; Tamborini, Lucia; Pennacchietti, Eugenia; Coluccia, Antonio; Silvestri, Romano; Cullia, Gregorio; De Micheli, Carlo; Conti, Paola; De Biase, Daniela - 01a Articolo in rivista
paper: JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY (Taylor & Francis Limited:Rankine Road, Basingstoke RG24 8PR United Kingdom:011 44 1256 813035, EMAIL: madeline.sims@tandf.co.uk, info@tandf.co.uk, INTERNET: http://www.tandf.co.uk, Fax: 011 44 1256 330245) pp. 295-301 - issn: 1475-6366 - wos: WOS:000368719800014 (15) - scopus: 2-s2.0-84955443104 (15)

11573/854568 - 2015 - Poster: "In vivo selection of JARID histone demethylases inhibitors and their use to enlighten the biological role of these enzymes in yeast and mammalian cells with focus on transcriptional regulation”
Danovska, Svetlana; Cundari, Enrico; Mannironi, Cecilia; Licursi, Valerio; Rinaldi, Teresa; Fabozzi, Simone; Cerini, Valentina; Proietto, Marco; Pippa, Simone; Coluccia, Antonio; La Regina, Giuseppe; Silvestri, Romano; Negri, Rodolfo - 04a Atto di comunicazione a congresso
conference: ICYGMB - Internationa Congress of Yeast Genetics and Molecular Biology (Levico Terme (TN))
book: Abstracts of the 27th International Conference on Yeast Genetics and Molecular Biology - ()

11573/1738905 - 2015 - Drug design, synthesis and biological evaluation of new antiretroviral agents
Famiglini, V.; La Regina, G.; Coluccia, A.; Brancale, B.; Esté, J. A.; Silvestri, R. - 04f Poster
conference: Workshop sulla Ricerca (Roma, Italy)
book: Abstract Book - ()

11573/868769 - 2015 - Drug Design and Synthesis of New Indolylarylsulfones as HIV-1 Non-nucleoside Reverse Transcriptase Inhibitors
Famiglini, Valeria; La Regina, Giuseppe; Coluccia, Antonio; Brancale, Andrea; Esté, José A.; Silvestri, Romano - 04a Atto di comunicazione a congresso
conference: XXIII National Meeting on Medicinal Chemistry - Nuove Prospettive in Chimica Farmaceutica 9° Meeting (Fisciano)
book: Abstract eBook - ()

11573/845844 - 2015 - New Indole Tubulin Assembly Inhibitors Cause Stable Arrest of Mitotic Progression, Enhanced Stimulation of Natural Killer Cell Cytotoxic Activity, and Repression of Hedgehog-Dependent Cancer
La Regina, Giuseppe; Bai, Ruoli; Coluccia, Antonio; Famiglini, Valeria; Pelliccia, Sveva; Passacantilli, Sara; Mazzoccoli, Carmela; Ruggieri, Vitalba; Verrico, Annalisa; Miele, Andrea; Monti, Ludovica; Nalli, Marianna; Alfonsi, Romina; Di Marcotullio, Lucia; Gulino, Alberto; Ricci, Biancamaria; Soriani, Alessandra; Santoni, Angela; Caraglia, Michele; Porto, Stefania; Da Pozzo, Eleonora; Martini, Claudia; Brancale, Andrea; Marinelli, Luciana; Novellino, Ettore; Vultaggio, Stefania; Varasi, Mario; Mercurio, Ciro; Bigogno, Chiara; Dondio, Giulio; Hamel, Ernest; Lavia, Patrizia; Silvestri, Romano - 01a Articolo in rivista
paper: JOURNAL OF MEDICINAL CHEMISTRY (Washington, DC: American Chemical Society) pp. 5789-5807 - issn: 0022-2623 - wos: WOS:000359683700008 (57) - scopus: 2-s2.0-84939138196 (58)

11573/845349 - 2015 - Discovery of 1,1'-biiphenyl-4-sulfonamides as a new class of potent and selective carbonic anhydrase XIV inhibitors
La Regina, Giuseppe; Coluccia, Antonio; Famiglini, Valeria; Pelliccia, Sveva; Monti, Ludovica; Vullo, Daniela; Nuti, Elisa; Alterio, Vincenzo; De Simone, Giuseppina; Monti, Simona Maria; Pan, Peiwen; Parkkila, Seppo; Supuran, Claudiu T.; Rossello, Armando; Silvestri, Romano - 01a Articolo in rivista
paper: JOURNAL OF MEDICINAL CHEMISTRY (Washington, DC: American Chemical Society) pp. 8564-8572 - issn: 0022-2623 - wos: WOS:000364796100017 (37) - scopus: 2-s2.0-84947266183 (40)

11573/868746 - 2015 - New indole tubulin assembly inhibitors with stable arrest of mitotic progression, enhanced stimulation of natural killer cell cytotoxic activity and repression of Hedgehog-dependent cancer
La Regina, Giuseppe; Coluccia, Antonio; Hamel, Ernest; Novellino, Ettore; Silvestri, Romano - 04a Atto di comunicazione a congresso
conference: Spanish-Italian Medicinal Chemistry Congress (Barcellona, Spagna)
book: SIMCC2015 - ()

11573/872560 - 2015 - In vitro characterisation of a pleconaril/pirodavir-like compound with potent activity against rhinoviruses
Lacroix, Céline; Laconi, Samuela; Angius, Fabrizio; Coluccia, Antonio; Silvestri, Romano; Pompei, Raffaello; Neyts, Johan; Leyssen, Pieter - 01a Articolo in rivista
paper: VIROLOGY JOURNAL (London : Biomed Central) pp. - - issn: 1743-422X - wos: WOS:000357775400001 (27) - scopus: 2-s2.0-84937203434 (30)

11573/663213 - 2015 - New 1-phenyl-5-(1H-pyrrol-1-yl)-1H-pyrazole-3-carboxamides inhibit hepatitis C virus replication via suppression of cyclooxygenase-2
Manvar, D.; Pelliccia, S.; La Regina, G.; Famiglini, V.; Coluccia, A.; Ruggieri, A.; Anticoli, S.; Lee, J. -C.; Basu, A.; Cevik, O.; Nencioni, L.; Palamara, A. T.; Zamperini, C.; Botta, M.; Neyts, J.; Leyssen, P.; Kaushik-Basu, N.; Silvestri, R. - 01a Articolo in rivista
paper: EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY (Editions Scientifique & Medical Elsevier:23 Rue Linois, F 75724 Paris Cedex 15 France:011 33 1 71724646, INTERNET: http://www.elsevier.fr, Fax: 011 33 1 71724664) pp. 497-506 - issn: 0223-5234 - wos: WOS:000348951900040 (27) - scopus: 2-s2.0-84914680268 (31)

11573/1738903 - 2015 - Design and synthesis of new potent tubulin polymerization inhibitors
Passacantilli, S.; La Regina, G.; Coluccia, A.; Creta, M.; Hamel, E.; Novellino, E.; Silvestri, R. - 04f Poster
conference: Workshop sulla Ricerca (Roma, Italy)
book: Abstract Book - ()

11573/868759 - 2015 - Synthesis of New Indoles with Potent Tubulin Polymerization Inhibiting Activity Including Hedgehog-Dependent Cancer and Enhanced Stimulation of NK Cell Cytotoxic Activity
Passacantilli, Sara; La Regina, Giuseppe; Coluccia, Antonio; Creta, Matteo; Hamel, Ernest; Novellino, Ettore; Silvestri, Romano - 04a Atto di comunicazione a congresso
conference: XXIII National Meeting on Medicinal Chemistry - Nuove Prospettive in Chimica Farmaceutica 9° Meeting (Fisciano)
book: Abstract eBook - ()

11573/764095 - 2015 - Structure-based lead optimization and biological evaluation of BAX direct activators as novel potential anticancer agents
Stornaiuolo, M.; La Regina, Giuseppe; Passacantilli, Sara; Grassia, G.; Coluccia, Antonio; La Pietra, V.; Giustiniano, M.; Cassese, H.; Di Maro, S.; Brancaccio, D.; Taliani, S.; Ialenti, A.; Silvestri, Romano; Martini, C.; Novellino, E.; Marinelli, L. - 01a Articolo in rivista
paper: JOURNAL OF MEDICINAL CHEMISTRY (Washington, DC: American Chemical Society) pp. 2135-2148 - issn: 0022-2623 - wos: WOS:000351186500007 (36) - scopus: 2-s2.0-84924664711 (38)

11573/538415 - 2014 - An High-Throughput In Vivo Screening System to Select H3K4-Specific Histone Demethylase Inhibitors
Cecilia, Mannironi; Proietto, Marco; Bufalieri, Francesca; Enrico, Cundari; Alagia, Angela Alessandra; Danovska, Svetlana; Rinaldi, Teresa; Famiglini, Valeria; Coluccia, Antonio; La Regina, Giuseppe; Silvestri, Romano; Negri, Rodolfo - 01a Articolo in rivista
paper: PLOS ONE (San Francisco, CA : Public Library of Science) pp. e86002-e86002 - issn: 1932-6203 - wos: WOS:000330570000022 (15) - scopus: 2-s2.0-84900435770 (16)

11573/675447 - 2014 - New modulator of the tumoural immune escape via Indoleamin 2,3-dioxygenase (IDO) inhibition.
Coluccia, Antonio; La Regina, Giuseppe; Okuno, A.; Takikawa, O.; Silvestri, Romano - 04a Atto di comunicazione a congresso
conference: XXV Congresso Nazionale della Società Chimica Italiana (Arcavacata di Rende)
book: Atti del Congresso - ()

11573/675493 - 2014 - New Indolylarylsulfones as Potent and Broad Spectrum HIV-1 Non-Nucleoside Reverse Transcriptase Inhibitors.
Famiglini, Valeria; La Regina, Giuseppe; Coluccia, Antonio; Brancale, A.; Esté, J. A.; Silvestri, Romano - 04a Atto di comunicazione a congresso
conference: International Conference on Antiviral Research (Raleigh, USA)
book: Program and Abstracts - ()

11573/675451 - 2014 - New Indolylarylsulfones as Potent and Broad Spectrum HIV‐1 Non-Nucleoside Reverse Transcriptase Inhibitors. II.
Famiglini, Valeria; La Regina, Giuseppe; Coluccia, Antonio; Brancale, A.; Novellino, E.; Silvestri, Romano - 04a Atto di comunicazione a congresso
conference: Nuove Prospettive in Chimica Farmaceutica - VIII Edizione del Meeting (Parma)
book: Book degli Abstracts - ()

11573/671843 - 2014 - Indolylarylsulfones carrying a heterocyclic tail as very potent and broad spectrum HIV-1 non-nucleoside reverse transcriptase inhibitors
Famiglini, Valeria; La Regina, Giuseppe; Coluccia, Antonio; Pelliccia, S.; Brancale, A.; Maga, G.; Crespan, E.; Badia, R.; Riveira Munoz, E.; Este, J. A.; Ferretti, R.; Cirilli, R.; Zamperini, C.; Botta, M.; Schols, D.; Limongelli, V.; Agostino, B.; Novellino, E.; Silvestri, Romano - 01a Articolo in rivista
paper: JOURNAL OF MEDICINAL CHEMISTRY (Washington, DC: American Chemical Society) pp. 9945-9957 - issn: 0022-2623 - wos: WOS:000346321200017 (44) - scopus: 2-s2.0-84918566396 (49)

11573/559735 - 2014 - New indolylarylsulfones as highly potent and broad spectrum HIV-1 non-nucleoside reverse transcriptase inhibitors
Famiglini, Valeria; La Regina, Giuseppe; Coluccia, Antonio; Pelliccia, S; Brancale, A; Maga, G; Crespan, E; Badia, R; Clotet, B; Este J., A; Cirilli, R; Novellino, E; Silvestri, Romano - 01a Articolo in rivista
paper: EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY (Editions Scientifique & Medical Elsevier:23 Rue Linois, F 75724 Paris Cedex 15 France:011 33 1 71724646, INTERNET: http://www.elsevier.fr, Fax: 011 33 1 71724664) pp. 101-111 - issn: 0223-5234 - wos: WOS:000337985400009 (22) - scopus: 2-s2.0-84899103627 (24)

11573/649699 - 2014 - New Pyrrole Derivatives with Potent Tubulin Polymerization Inhibiting Activity As Anticancer Agents Including Hedgehog-Dependent Cancer
La Regina, Giuseppe; Bai, R; Coluccia, Antonio; Famiglini, Valeria; Pelliccia, Sveva; Passacantilli, Sara; Mazzoccoli, C; Ruggieri, V; Sisinni, L; Bolognesi, A; Rensen, W. M.; Miele, Andrea; Nalli, Marianna; Alfonsi, Romina; Di Marcotullio, Lucia; Gulino, Alberto; Brancale, A; Novellino, E; Dondio, G; Vultaggio, S; Varasi, M; Mercurio, C; Hamel, E; Lavia, P; Silvestri, Romano - 01a Articolo in rivista
paper: JOURNAL OF MEDICINAL CHEMISTRY (Washington, DC: American Chemical Society) pp. 6531-6552 - issn: 0022-2623 - wos: WOS:000340445900020 (82) - scopus: 2-s2.0-84906094556 (88)

11573/675499 - 2014 - 3-Aroyl-1-arylpyrroles: a new class of potent inhibitors of tubulin polymerization
La Regina, Giuseppe; Coluccia, Antonio; Passacantilli, Sara; Famiglini, Valeria; Pelliccia, S.; Hamel, E.; Novellino, E.; Silvestri, R. - 04f Poster
conference: Fifth European Workshop in Drug Synthesis (Siena, Italy)
book: Abstract Book - ()

11573/675361 - 2014 - 3-Aroyl-1-arylpyrroles as new anticancer agents
La Regina, Giuseppe; Coluccia, Antonio; Passacantilli, Sara; Famiglini, Valeria; Pelliccia, S.; Hamel, E.; Novellino, E.; Silvestri, Romano - 04a Atto di comunicazione a congresso
conference: XXV Congresso Nazionale della Società Chimica Italiana (Arcavacata di Rende (CS))
book: Atti del Congresso - ()

11573/675406 - 2014 - 3-Aroyl-1-arylpyrroles: a new class of potent inhibitors of tubulin polymerization
La Regina, Giuseppe; Coluccia, Antonio; Passacantilli, Sara; Famiglini, Valeria; Pelliccia, Sveva; Hamel, E.; Novellino, E.; Silvestri, Romano - 04a Atto di comunicazione a congresso
conference: Fifth European Workshop in Drug Synthesis (Siena (SI))
book: Fifth European Workshop in Drug Synthesis - ()

11573/671846 - 2014 - Discovery of biarylaminoquinazolines as novel tubulin polymerization inhibitors
Marzaro, G.; Coluccia, Antonio; Ferrarese, A.; Brun, P.; Castagliuolo, I.; Conconi, M. T.; La Regina, Giuseppe; Bai, R.; Silvestri, Romano; Hamel, E.; Chilin, A. - 01a Articolo in rivista
paper: JOURNAL OF MEDICINAL CHEMISTRY (Washington, DC: American Chemical Society) pp. 4598-4605 - issn: 0022-2623 - wos: WOS:000337336600014 (30) - scopus: 2-s2.0-84902438483 (29)

11573/555507 - 2013 - Computer-aided identification, design and synthesis of a novel series of compounds with selective antiviral activity against chikungunya virus.
Bassetto, M.; De Burghgraeveb, T.; Delangb, L.; Massarotti, A.; Zonta, N.; Gatti, Valerio; Colombano, G.; Sorba, G.; Silvestri, Romano; Tron, G. C.; Neyts, J.; Leyssen, P.; Brancale, A.; Coluccia, Antonio - 01a Articolo in rivista
paper: ANTIVIRAL RESEARCH ([Amsterdam]; [New York]: Elsevier/North-Holland, [c1981]-) pp. 12-18 - issn: 0166-3542 - wos: WOS:000318466200003 (88) - scopus: 2-s2.0-84874632357 (101)

11573/675503 - 2013 - Computational studies of colchicine site compounds.
Coluccia, Antonio; La Regina, Giuseppe; Brancale, A.; Silvestri, Romano - 04a Atto di comunicazione a congresso
conference: XXII National Meeting on Medicinal Chemistry (Roma)
book: Abstract Book - ()

11573/547290 - 2013 - Drug design and synthesis of GSK-3β inhibitors.
Famiglini, Valeria; Bordoni, C.; La Pietra, V.; La Regina, Giuseppe; Coluccia, Antonio; Pelliccia, S.; Plotkin, B.; Eldar Finkelman, H.; Brancale, A.; Marinelli, L.; Novellino, E.; Silvestri, Romano - 04a Atto di comunicazione a congresso
conference: XXII National Meeting on Medicinal Chemistry (Roma)
book: Abstract Book - ()

11573/546082 - 2013 - Arylsulfone-based HIV-1 non-nucleoside reverse transcriptase inhibitors
Famiglini, Valeria; Coluccia, Antonio; Andrea, Brancale; Sveva, Pelliccia; La Regina, Giuseppe; Silvestri, Romano - 01a Articolo in rivista
paper: FUTURE MEDICINAL CHEMISTRY (London : Future Science, 2009-.) pp. 2141-2156 - issn: 1756-8919 - wos: WOS:000327222400008 (17) - scopus: 2-s2.0-84889578221 (18)

11573/547288 - 2013 - New indolylarylsulfones as potent and broad spectrum HIV-1 non-nucleoside reverse transcriptase inhibitors.
Famiglini, Valeria; La Regina, Giuseppe; Coluccia, Antonio; Brancale, A.; Novellino, E.; Silvestri, Romano - 04a Atto di comunicazione a congresso
conference: XXII National Meeting on Medicinal Chemistry (Roma)
book: Abstract Book - ()

11573/509896 - 2013 - Toward Highly Potent Cancer Agents by Modulating the C-2 Group of the Arylthioindole Class of Tubulin Polymerization Inhibitors
La Regina, Giuseppe; Ruoli, Bai; Whilelmina Maria, Rensen; Di Cesare, Erica; Coluccia, Antonio; Piscitelli, Francesco; Famiglini, Valeria; Alessia, Reggio; Nalli, Marianna; Pelliccia, Sveva; Eleonora Da, Pozzo; Barbara, Costa; Ilaria, Granata; Amalia, Porta; Bruno, Maresca; Soriani, Alessandra; Iannitto, Maria Luisa; Santoni, Angela; Junjie, Li; M. M., Cona; Feng, Chen; Yicheng, Ni; Andrea, Brancale; Giulio, Dondio; Stefania, Vultaggio; Mario, Varasi; Ciro, Mercurio; Claudia, Martini; Ernest, Hamel; Patrizia, Lavia; Ettore, Novellino; Silvestri, Romano - 01a Articolo in rivista
paper: JOURNAL OF MEDICINAL CHEMISTRY (Washington, DC: American Chemical Society) pp. 123-149 - issn: 0022-2623 - wos: WOS:000313221600012 (123) - scopus: 2-s2.0-84872352365 (123)

11573/684051 - 2013 - S[+] Apomorphine is a CNS penetrating activator of the Nrf2-ARE pathway with activity in mouse and patient fibroblast models of amyotrophic lateral sclerosis.
Mead, R. J.; Higginbottom, A.; Allen, S. P.; Kirby, J.; Bennett, E.; Barber, S. C.; Heath, P. R.; Coluccia, Antonio; Patel, N.; Gardner, I.; Brancale, A.; Grierson, A. J.; Shaw, P. J. - 01a Articolo in rivista
paper: FREE RADICAL BIOLOGY & MEDICINE (Elsevier Science Limited:Oxford Fulfillment Center, PO Box 800, Kidlington Oxford OX5 1DX United Kingdom:011 44 1865 843000, 011 44 1865 843699, EMAIL: asianfo@elsevier.com, tcb@elsevier.co.UK, INTERNET: http://www.elsevier.com, http://www.elsevier.com/locate/shpsa/, Fax: 011 44 1865 843010) pp. 438-452 - issn: 0891-5849 - wos: WOS:000320687300042 (56) - scopus: 2-s2.0-84878124559 (58)

11573/547286 - 2013 - Highly potent cancer agents by modulating the C-2 group of the arylthioindole class of tubulin polymerization inhibitors.
Pelliccia, S.; La Regina, Giuseppe; Coluccia, Antonio; Famiglini, Valeria; Nalli, M.; Brancale, A.; Hamel, E.; Novellino, E.; Silvestri, Romano - 04a Atto di comunicazione a congresso
conference: XXII National Meeting on Medicinal Chemistry (Roma)
book: Abstract Book - ()

11573/675507 - 2013 - Highly potent cancer agents by modulating the C-2 group of the arylthioindole class of tubulin polymerization inhibitors.
Pelliccia, S.; La Regina, Giuseppe; Coluccia, Antonio; Famiglini, Valeria; Reggio, A.; Brancale, A.; Hamel, E.; Novellino, E.; Silvestri, R. - 04a Atto di comunicazione a congresso
conference: Nuove Prospettive in Chimica Farmaceutica 7 (Savigliano)
book: Abstract Book - ()

11573/541254 - 2013 - Design, synthesis, and biological evaluation of 1-phenylpyrazolo[3,4-e]pyrrolo[3,4-g]indolizine-4,6(1H,5H)-diones as new glycogen synthase kinase-3β inhibitors
V., La Pietra; La Regina, Giuseppe; Coluccia, Antonio; Famiglini, Valeria; S., Pelliccia; B., Plotkin; H., Eldar Finkelman; A., Brancale; C., Ballatore; A., Crowe; Kr, Brunden; L., Marinelli; E., Novellino; Silvestri, Romano - 01a Articolo in rivista
paper: JOURNAL OF MEDICINAL CHEMISTRY (Washington, DC: American Chemical Society) pp. 10066-10078 - issn: 0022-2623 - wos: WOS:000329331600018 (36) - scopus: 2-s2.0-84891341466 (43)

11573/501681 - 2012 - Computer aided drug design approach in the development of PKnB inhibitors as potential antimycobacterial agents.
Coluccia, Antonio; La Regina, Giuseppe; Piscitelli, Francesco; E., Novellino; Silvestri, Romano - 04a Atto di comunicazione a congresso
conference: Meeting Nuove Prospettive in Chimica Farmaceutica 6 (Riccione)
book: Abstracts - ()

11573/501381 - 2012 - New Indolylarylsulfones as Potent and Broad Spectrum HIV-1 Non-Nucleoside Reverse Transcriptase Inhibitors
Famiglini, Valeria; La Regina, Giuseppe; Coluccia, Antonio; A., Brancale; E., Novellino; Silvestri, Romano - 04a Atto di comunicazione a congresso
conference: 12° Sigma Aldrich Young Chemists Symposium (Riccione)
book: Abstracts - ()

11573/461861 - 2012 - New Nitrogen Containing Substituents at the Indole-2-carboxamide Yield High Potent and Broad Spectrum Indolylarylsulfone HIV-1 Non-Nucleoside Reverse Transcriptase Inhibitors
La Regina, Giuseppe; Coluccia, Antonio; Andrea, Brancale; Piscitelli, Francesco; Famiglini, Valeria; Sandro, Cosconati; Giovanni, Maga; Alberta, Samuele; E., Gonzales; Bonaventura, Clotet; Dominique, Schols; Jose A., Este; Ettore, Novellino; Silvestri, Romano - 01a Articolo in rivista
paper: JOURNAL OF MEDICINAL CHEMISTRY (Washington, DC: American Chemical Society) pp. 6634-6638 - issn: 0022-2623 - wos: WOS:000306764600035 (54) - scopus: 2-s2.0-84864247649 (64)

11573/681651 - 2012 - The tubulin colchicine domain: a molecular modelling perspective.
Massarotti, A.; Coluccia, Antonio; Silvestri, Romano; Brancale, A. - 01a Articolo in rivista
paper: CHEMMEDCHEM (Weinheim : Wiley-VCH-Verl..) pp. 33-42 - issn: 1860-7179 - wos: WOS:000298549100003 (146) - scopus: 2-s2.0-84555195099 (150)

11573/555514 - 2012 - De novo computer-aided design of novel antiviral agents.
Massarotti, A.; Coluccia, Antonio; Sorba, G.; Silvestri, Romano; Brancale, A. - 01a Articolo in rivista
paper: DRUG DISCOVERY TODAY (Elsevier Science Limited Trends Journals:PO Box 331, Haywards Heath RH16 3FG United Kingdom:011 44 1444 475651, EMAIL: ct.subs@rbi.co.uk, Fax: 011 44 1444 445423) pp. 213-218 - issn: 1359-6446 - wos: (0) - scopus: 2-s2.0-84873076621 (2)

11573/502138 - 2012 - Indole-2-carboxamides as Allosteric Modulators of the Cannabinoid CB1 Receptor
Piscitelli, Francesco; A., Ligresti; La Regina, Giuseppe; Coluccia, Antonio; L., Morera; M., Allara; E., Novellino; V., Di Marzo; Silvestri, Romano - 01a Articolo in rivista
paper: JOURNAL OF MEDICINAL CHEMISTRY (Washington, DC: American Chemical Society) pp. 5627-5631 - issn: 0022-2623 - wos: WOS:000305356400058 (60) - scopus: 2-s2.0-84862272370 (60)

11573/501390 - 2012 - New 2-Heterocyclil-3-arylthio-1H-indoles as potent tubulin polymerization and cell growth inhibitors
S., Pelliccia; La Regina, Giuseppe; Coluccia, Antonio; A., Brancale; E., Novellino; Silvestri, Romano - 04a Atto di comunicazione a congresso
conference: 12° Sigma Aldrich Young Chemists Symposium (Riccione)
book: Abstracts - ()

11573/396005 - 2011 - Indolylarylsulfones as HIV-1 Non-Nucleoside Reverse Transcriptase Inhibitors. New Cyclic Substituents at the Indole-2-carboxamide.
Coluccia, Antonio; La Regina, Giuseppe; Gatti, Valerio; Piscitelli, Francesco; Famiglini, V.; Brancale, A.; Maga, G.; Balzarini, J.; Novellino, E.; Silvestri, Romano - 04a Atto di comunicazione a congresso
conference: XXIV Congresso Nazionale della Società Chimica Italiana (Lecce)
book: Atti del Congresso - ()

11573/897778 - 2011 - Molecular modelling studies on Arylthioindoles as potent inhibitors of tubulin polymerization
Coluccia, Antonio; Sabbadin, Davide; Brancale, Andrea - 01a Articolo in rivista
paper: EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY (Editions Scientifique & Medical Elsevier:23 Rue Linois, F 75724 Paris Cedex 15 France:011 33 1 71724646, INTERNET: http://www.elsevier.fr, Fax: 011 33 1 71724664) pp. 3519-3525 - issn: 0223-5234 - wos: WOS:000292670000038 (19) - scopus: 2-s2.0-79958256962 (20)

11573/355392 - 2011 - Indolylarylsulfones as HIV-1 non-nucleoside reverse transcriptase inhibitors. New cyclic substituents at the Indole-2-carboxamide
La Regina, Giuseppe; Coluccia, Antonio; A., Brancale; G., Maga; J., Balzarini; E., Novellino; Silvestri, Romano - 04d Abstract in atti di convegno
conference: The 24th International Meeting on Antiviral Research (Sofia; Bulgaria)
book: Abstracts - ()

11573/502235 - 2011 - Indolylarylsulfones as HIV-1 Non-Nucleoside Reverse Transcriptase Inhibitors: New Cyclic Substituents at the Indole-2-carboxamide.
La Regina, Giuseppe; Coluccia, Antonio; A., Brancale; Piscitelli, Francesco; Gatti, Valerio; G., Maga; A., Samuele; C., Pannecouque; D., Schols; J., Balzarini; E., Novellino; Silvestri, Romano - 01a Articolo in rivista
paper: JOURNAL OF MEDICINAL CHEMISTRY (Washington, DC: American Chemical Society) pp. 1587-1598 - issn: 0022-2623 - wos: WOS:000288400700005 (133) - scopus: 2-s2.0-79952792724 (164)

11573/502225 - 2011 - Design and Synthesis of 2-Heterocyclyl-3-arylthio-1H-indoles as Potent Tubulin Polymerization and Cell Growth Inhibitors with Improved Metabolic Stability
La Regina, Giuseppe; Ruoli, Bai; Willeke, Rensen; Coluccia, Antonio; Piscitelli, Francesco; Gatti, Valerio; Alessio, Bolognesi; Antonio, Lavecchia; Ilaria, Granata; Amalia, Porta; Bruno, Maresca; Soriani, Alessandra; Iannitto, Maria Luisa; Marisa, Mariani; Santoni, Angela; Andrea, Brancale; Cristiano, Ferlini; Giulio, Dondio; Mario, Varasi; Ciro, Mercurio; Ernest, Hamel; Patrizia, Lavia; Ettore, Novellino; Silvestri, Romano - 01a Articolo in rivista
paper: JOURNAL OF MEDICINAL CHEMISTRY (Washington, DC: American Chemical Society) pp. 8394-8406 - issn: 0022-2623 - wos: WOS:000297946300016 (77) - scopus: 2-s2.0-84055211830 (82)

11573/355390 - 2010 - Molecular dynamic studies of arylthioindoles, potent inhibitors of tubulin polymerization
Coluccia, A; Brancale, A; Silvestri, Romano - 04a Atto di comunicazione a congresso
conference: XX national Meeting on Medicinal Chemistry (Abano Terme, Padova)
book: Book of Abstracts - ()

11573/355731 - 2010 - Discovery of a novel hcv helicase inhibitors by a de novo design approach.
Coluccia, A; Leyssen, P; Neyts, J; Kandil, S; Brancale, A; Silvestri, Romano - 04a Atto di comunicazione a congresso
conference: XX national Meeting on Medicinal Chemistry (Abano Terme, Padova)
book: Book of Abtracts - ()

11573/355391 - 2010 - Indolylarylsulfones bearing natural and unnatural amino acids as inhibitors of HIV-1 reverse transcriptase and Coxsackie B4 virus.
Gatti, Valerio; La Regina, Giuseppe; Coluccia, Antonio; Piscitelli, Francesco; C., Giordano; A., Brancale; J., Balzarini; G., Maga; E., Novellino; Silvestri, Romano - 04a Atto di comunicazione a congresso
conference: Antiviral Congress (Amsterdam (NL))
book: Abstracts - ()

11573/366769 - 2010 - Looking for an active conformation of the future HIV type-1 non-nucleoside reverse transcriptase inhibitors
La Regina, Giuseppe; Coluccia, Antonio; Silvestri, Romano - 01a Articolo in rivista
paper: ANTIVIRAL CHEMISTRY & CHEMOTHERAPY (International Medical Press:2-4 Idol Lane, London EC3R 5DD United Kingdom:011 44 207 3980700, EMAIL: imp@intmedpress.com, INTERNET: http://www.intmedpress.com, Fax: 011 44 207 3980701) pp. 213-237 - issn: 0956-3202 - wos: (0) - scopus: 2-s2.0-77956900680 (66)

11573/349425 - 2010 - Advanced in silico approaches in antiviral research
Zonta, N; Coluccia, Antonio; Brancale, A. - 01a Articolo in rivista
paper: ANTIVIRAL CHEMISTRY & CHEMOTHERAPY (International Medical Press:2-4 Idol Lane, London EC3R 5DD United Kingdom:011 44 207 3980700, EMAIL: imp@intmedpress.com, INTERNET: http://www.intmedpress.com, Fax: 011 44 207 3980701) pp. 147-151 - issn: 0956-3202 - wos: (0) - scopus: 2-s2.0-77949679042 (4)

11573/225640 - 2009 - Molecular Modeling applications studies on the Indolyl Aryl Sulphones (IASs) as HIV-1 Non-Nucleotidic Reverse transcriptase inhibitors.
Coluccia, Antonio; Brancale, A.; La Regina, Giuseppe; Lavecchia, A.; Silvestri, Romano - 04a Atto di comunicazione a congresso
book: Abstracts - ()

11573/225842 - 2009 - Drug Design of New NS3/4A HCV Serine Protease Inhibitors. Structure-Based and Ligand-Based Approaches.
Coluccia, Antonio; La Regina, Giuseppe; Giordano, C.; Sansone, A.; Brancale, A.; Neyts, J.; Leyssen, P.; Novellino, E.; Silvestri, Romano - 04a Atto di comunicazione a congresso
conference: XXIII Congresso Nazionale della Società Chimica Italiana (Sorrento (NA))
book: Atti del Congresso - ()

11573/226395 - 2009 - Arylthioindole Bioisosteres as Potent Tubulin Polymerization and MCF-7 Cell Growth Inhibitors
Gatti, Valerio; La Regina, Giuseppe; Coluccia, Antonio; Brancale, A.; Hamel, E.; Scovassi, A.; Maresca, B.; Campiglia, P.; Novellino, E.; Silvestri, Romano - 04a Atto di comunicazione a congresso
conference: XXIII Congresso Nazionale della Società Chimica Italiana (Sorrento (NA))
book: Atti del Congresso - ()

11573/349422 - 2009 - Discovery of a novel HCV helicase inhibitor by a de novo drug design approach
Kandil, S; Biondaro, S; Vlachakis, D; Cummins, Ac; Coluccia, Antonio; Berry, C; Leyssen, P; Neyts, J; Brancale, A. - 01a Articolo in rivista
paper: BIOORGANIC & MEDICINAL CHEMISTRY LETTERS (Oxford: Pergamon, Amsterdam the Netherlands: Elsevier) pp. 2935-2937 - issn: 0960-894X - wos: WOS:000265981900006 (36) - scopus: 2-s2.0-65549144355 (43)

11573/226478 - 2009 - Molecular modeling studies of arylthioindoles and related bioisosteres, potent inhibitors of tubulin polymerization
La Regina, Giuseppe; Coluccia, Antonio; Gatti, Valerio; Saletti, R.; Brancale, A.; Novellino, E.; Silvestri, Romano - 04f Poster
conference: VI European Workshop in Drug Design (Siena, Italy)
book: Abstracts - ()

11573/358688 - 2009 - New arylthioindoles and related bioisosteres at the sulfur bridging group. 4. Synthesis, tubulin polymerization, cell growth inhibition, and molecular modeling studies
La Regina, Giuseppe; Taradas, Sarkar; Ruoli, Bai; Michael C., Edler; Roberto, Saletti; Coluccia, Antonio; Piscitelli, Francesco; Lara, Minelli; Gatti, Valerio; Carmela, Mazzoccoli; Palermo, Vanessa; Mazzoni, Cristina; Falcone, Claudio; Anna Ivana, Scovassi; Vincenzo, Giansanti; Pietro, Campiglia; Amalia, Porta; Bruno, Maresca; Ernest, Hamel; Andrea, Brancale; Ettore, Novellino; Silvestri, Romano - 01a Articolo in rivista
paper: JOURNAL OF MEDICINAL CHEMISTRY (Washington, DC: American Chemical Society) pp. 7512-7527 - issn: 0022-2623 - wos: WOS:000272338000020 (95) - scopus: 2-s2.0-72249084715 (101)

11573/226394 - 2009 - Indolylarylsulfones Bearing Natural and Unnatural Amino Acids are Potent HIV-1 Reverse Transcriptase and Coxsackie B4 Virus Non-Nucleoside Inhibitors.
Piscitelli, Francesco; Coluccia, Antonio; Brancale, A.; La Regina, Giuseppe; Sansone, A.; Giordano, C.; Balzarini, J.; Maga, G.; Zanoli, S.; Samuele, A.; Cirilli, R.; La Torre, F.; Lavecchia, A.; Novellino, E.; Silvestri, Romano - 04a Atto di comunicazione a congresso
conference: The 22nd International Meeting on Antiviral Research (Miami Beach, Florida, USA)
book: Abstracts - ()

11573/364587 - 2009 - Indolyl Aryl Sulfones bearing Natural and Unnatural Aminoacids. Discovery of Potent Inhibitors of both HIV-1 Non-Nucleoside Wild Type and Resistant Mutant Strains Reverse Transcriptase, and Coxsackie B4 Virus.
Piscitelli, Francesco; Coluccia, Antonio; Brancale, A.; La Regina, Giuseppe; Sansone, A.; Giordano, C.; Balzarini, J.; Maga, G.; Zanoli, S.; Samuele, A.; Cirilli, R.; La Torre, F.; Lavecchia, A.; Novellino, E.; Silvestri, Romano - 01a Articolo in rivista
paper: JOURNAL OF MEDICINAL CHEMISTRY (Washington, DC: American Chemical Society) pp. 1922-1934 - issn: 0022-2623 - wos: WOS:000264835800014 (61) - scopus: 2-s2.0-64549155260 (64)

11573/225843 - 2009 - Indolylarylsulfones Bearing Natural and Unnatural Amino Acids as Potent HIV-1 NNRTIs.
Piscitelli, Francesco; La Regina, Giuseppe; Gatti, Valerio; Coluccia, Antonio; Brancale, A.; Giordano, C.; Balzarini, J.; Maga, G.; Lavecchia, A.; Novellino, E.; Silvestri, Romano - 04a Atto di comunicazione a congresso
conference: XXIII Congresso Nazionale della Società Chimica Italiana (Sorrento (NA))
book: Atti del Congresso - ()

11573/224410 - 2008 - Progress in the development of arylthioindoles, potent inhibitors of tubulin polymerization and MCF-7 cell growth.
La Regina, Giuseppe; Piscitelli, Francesco; Coluccia, Antonio; Brancale, A.; Hamel, E.; Diaz, J. F.; Scovassi, A. I.; Lavecchia, A.; Novellino, E.; Silvestri, Romano - 04a Atto di comunicazione a congresso
conference: XIX National Meeting on Medicinal Chemistry (Verona, Italy)
book: Book of Abstracts - ()

11573/396351 - 2008 - Progress in the development of arylthioindoles, potent inhibitors of tubulin polymerization and MCF-7 cell growth.
La Regina, Giuseppe; Piscitelli, Francesco; Coluccia, Antonio; Brancale, A.; Hamel, E.; Diaz, J. F.; Scovassi, A. I.; Lavecchia, A.; Novellino, E.; Silvestri, Romano - 04a Atto di comunicazione a congresso
conference: Strutture Eteroclicliche nella Ricerca Farmaceutica (Palermo)
book: Atti - ()

11573/224408 - 2008 - Docking and Molecular Dynamics Studies of Arylthioindoles.
La Regina, Giuseppe; Piscitelli, Francesco; Coluccia, Antonio; Minelli, L.; Brancale, A.; Kandil, S.; Lavecchia, A.; Novellino, E.; Silvestri, Romano - 04a Atto di comunicazione a congresso
conference: XIX National Meeting on Medicinal Chemistry (Verona, Italy)
book: Book of Abstracts - ()

11573/396552 - 2008 - Docking and Molecular Dynamics Studies of Arylthioindoles.
La Regina, Giuseppe; Piscitelli, Francesco; Coluccia, Antonio; Minelli, L.; Brancale, A.; Kandil, S.; Lavecchia, A.; Novellino, E.; Silvestri, Romano - 04a Atto di comunicazione a congresso
conference: Strutture Eteroclicliche nella Ricerca Farmaceutica (Palermo)
book: Atti - ()

11573/349174 - 2008 - Cdc25B phosphatase inhibitors in cancer therapy: latest developments, trends and medicinal chemistry perspective.
Lavecchia, A; Coluccia, Antonio; Di Giovanni, C; Novellino, E. - 01a Articolo in rivista
paper: ANTI-CANCER AGENTS IN MEDICINAL CHEMISTRY (Hilversum : Bentham Science Publishers) pp. 843-856 - issn: 1871-5206 - wos: WOS:000261480500006 (30) - scopus: 2-s2.0-60549090062 (36)

11573/396610 - 2008 - Indolyl Aryl Sulfones with aminoacid units as potent HIV-1 NNRTIs.
Piscitelli, Francesco; La Regina, Giuseppe; Coluccia, Antonio; Sansone, A.; Giordano, C.; Bergamini, A.; Sinistro, A.; Cavazza, A.; Maga, G.; Samuele, A.; Zanoli, S.; Lavecchia, A.; Novellino, E.; Silvestri, Romano - 04a Atto di comunicazione a congresso
conference: Strutture Eteroclicliche nella Ricerca Farmaceutica (Palermo)
book: Atti - ()

11573/358071 - 2007 - Indolyl Aryl Sulfones as HIV-1 Non-Nucleoside Reverse Transcriptase Inhibitors: Role of Two Halogen Atoms at the Indole Ring in Developing New Analogues with Improved Antiviral Activity
La Regina, Giuseppe; Coluccia, Antonio; Piscitelli, Francesco; Bergamini, A.; Sinistro, A.; Cavazza, A.; Maga, G.; Samuele, A.; Zanoli, S.; Novellino, E.; Artico, Marino; Silvestri, Romano - 01a Articolo in rivista
paper: JOURNAL OF MEDICINAL CHEMISTRY (Washington, DC: American Chemical Society) pp. 5034-5038 - issn: 0022-2623 - wos: WOS:000249871300022 (53) - scopus: 2-s2.0-34948862163 (59)

11573/144595 - 2007 - Arylthioindole Inhibitors of Tubulin Polymerization. 3. Biological Evaluation, Structure−Activity Relationships and Molecular Modeling Studies
La Regina, Giuseppe; Edler, M. C.; Brancale, A.; Kandil, S.; Coluccia, Antonio; Piscitelli, Francesco; Hamel, E.; De Martino, G.; Matesanz, R.; Daz, J. F.; Scovassi, A. I.; Ennio, P.; Lavecchia, A.; Novellino, E.; Artico, Marino; Silvestri, Romano - 01a Articolo in rivista
paper: JOURNAL OF MEDICINAL CHEMISTRY (Washington, DC: American Chemical Society) pp. 2865-2874 - issn: 0022-2623 - wos: WOS:000247033900011 (200) - scopus: 2-s2.0-34250869030 (206)

11573/237477 - 2007 - Arylthioindoles: design, synthesis and biological activity
La Regina, Giuseppe; Piscitelli, Francesco; Coluccia, Antonio; Brancale, A.; Hamel, E.; Diaz, J. F.; Scovassi, A. I.; Lavecchia, A.; Novellino, E.; Silvestri, Romano - 04f Poster
conference: XVIII Convegno Nazionale della Divisione di Chimica Farmaceutica della Società Chimica Italiana (Chieti, Italy)
book: Abstract Book - ()

11573/234427 - 2007 - Arylthioindoles: docking and molecular dynamics studies
La Regina, Giuseppe; Piscitelli, Francesco; Coluccia, Antonio; Minelli, L.; Brancale, A.; Kandil, S.; Lavecchia, A.; Novellino, E.; Silvestri, Romano - 04f Poster
conference: XVIII Convegno Nazionale della Divisione di Chimica Farmaceutica della Società Chimica Italiana (Chieti)
book: Abstract Book - ()

11573/238314 - 2007 - Synthesis of Indol Aryl Sulfones bearing Natural and Unnatural Aminoacids as Potent HIV-1 Non-Nucleoside Reverse Transcriptase.
Piscitelli, Francesco; La Regina, Giuseppe; Coluccia, Antonio; Sansone, A.; Giordano, C.; Bergamini, A.; Sinistro, A.; Cavazza, A.; Maga, G.; Samuele, A.; Zanoli, S.; Lavecchia, A.; Novellino, E.; Silvestri, Romano - 04a Atto di comunicazione a congresso
conference: XVIII Convegno Nazionale della Divisione di Chimica Farmaceutica della Società Chimica Italiana (Chieti)
book: Atti del Convegno - ()

11573/363492 - 2007 - Indolyl aryl sulphones as HIV-1 reverse transcriptase inhibitors: docking and 3-D QSAR studies.
Ragno, Rino; Coluccia, Antonio; La Regina, Giuseppe; Silvestri, Romano - 01a Articolo in rivista
paper: EXPERT OPINION ON DRUG DISCOVERY (--London United Kingdom:Informa Healthcare -London : Informa Healthcare, 2006-.) pp. 87-114 - issn: 1746-0441 - wos: WOS:000207616400006 (7) - scopus: 2-s2.0-34447527787 (7)

11573/396668 - 2006 - Structure-Based and 3-D QSAR Drug Design of New Indolyl Aryl Sulfones.
Coluccia, Antonio; Ragno, Rino; La Regina, Giuseppe; Artico, Marino; Silvestri, Romano - 04a Atto di comunicazione a congresso
conference: XXII Congresso Nazionale della Società Chimica Italiana (Firenze)
book: Atti del Congresso - ()

11573/53434 - 2006 - Improved 3-D QSAR Model on Indolyl Aryl Sulfones: Design of potent anti-HIV-1 active against both wild type and mutant form of RT.
Coluccia, Antonio; Ragno, Rino; La Regina, Giuseppe; Silvestri, Romano - 04a Atto di comunicazione a congresso
conference: The 16th European Symposium on Quantitative Structure-Activity Relationships & Molecular Modelling (Civitavecchia)

11573/361589 - 2006 - New Arylthioindoles: Potent Inhibitors of Tubulin Polymerization. 2. Structure-Activity Relationships and Molecular Modeling Studies.
De Martino, G.; Edler, M. C.; La Regina, Giuseppe; Coluccia, Antonio; Barbera, M. C.; Barrow, D.; Nicholson, R. I.; Chiosis, G.; Brancale, A.; Hamel, E.; Artico, Marino; Silvestri, Romano - 01a Articolo in rivista
paper: JOURNAL OF MEDICINAL CHEMISTRY (Washington, DC: American Chemical Society) pp. 947-954 - issn: 0022-2623 - wos: WOS:000235826300014 (374) - scopus: 2-s2.0-32344432249 (386)

11573/144591 - 2006 - Indolyl aryl sulphones as HIV-1 non-nucleoside reverse transcriptase inhibitors: synthesis, biological evaluation and binding mode studies of new derivatives at indole-2-carbxamide.
De Martino, G.; La Regina, Giuseppe; Ragno, Rino; Coluccia, Antonio; Bergamini, A.; Caprini, C.; Sinistro, A.; Maga, G.; Crespan, E.; Artico, Marino; Silvestri, Romano - 01a Articolo in rivista
paper: ANTIVIRAL CHEMISTRY & CHEMOTHERAPY (International Medical Press:2-4 Idol Lane, London EC3R 5DD United Kingdom:011 44 207 3980700, EMAIL: imp@intmedpress.com, INTERNET: http://www.intmedpress.com, Fax: 011 44 207 3980701) pp. 59-77 - issn: 0956-3202 - wos: (0) - scopus: 2-s2.0-33745100897 (48)

11573/51618 - 2006 - COMBINE, VALIDATE and GRID/GOLPE Application on HIV-RT Inhibitors: Developing of Models from Experimental Available Ligand-Enzyme Complexes and Predictive Ability
Ragno, Rino; Coluccia, Antonio; Antonella, Caroli - 04a Atto di comunicazione a congresso
conference: The 16th European Symposium on Quantitative Structure-Activity Relationships & Molecular Modelling (Civitavecchia)
book: The 16th European Symposium on Quantitative Structure-Activity Relationships & Molecular Modelling. - ()

11573/359248 - 2006 - Design, molecular modeling, synthesis, and anti-HIV-1 activity of new indolyl aryl sulfones. Novel derivatives of the indole-2-carboxamide
Ragno, Rino; Coluccia, Antonio; La Regina, Giuseppe; Gabriella De, Martino; Piscitelli, Francesco; Antonio, Lavecchia; Ettore, Novellino; Alberto, Bergamini; Chiara, Ciaprini; Anna, Sinistro; Giovanni, Maga; Emanuele, Crespan; Artico, Marino; Silvestri, Romano - 01a Articolo in rivista
paper: JOURNAL OF MEDICINAL CHEMISTRY (Washington, DC: American Chemical Society) pp. 3172-3184 - issn: 0022-2623 - wos: WOS:000237832400018 (180) - scopus: 2-s2.0-33744831188 (189)

11573/57584 - 2006 - Indole nucleus as a selected pharmacophore for the design of novel highly anti-HIV RT inhibitors and also capable to inhibit tumor cell replication.
Silvestri, Romano; Artico, Marino; La Regina, Giuseppe; Piscitelli, Francesco; Coluccia, Antonio; Ragno, Rino - 04a Atto di comunicazione a congresso
conference: Hosts, Symbionts and Parasites: Molecular and Pharmacological Approaches (Roma)
book: Abstracts - ()

11573/233895 - 2005 - Arylthioindoles, Potent Inhibitors of Tubulin Polymerization.
De Martino, G.; La Regina, Giuseppe; Coluccia, Antonio; Piscitelli, Francesco; Edler, M. C.; Barbera, M. C.; Brancale, A.; Hamel, E.; Artico, Marino; Silvestri, Romano - 04a Atto di comunicazione a congresso
conference: Second Joint Italian - Swiss Meeting on Medicinal Chemistry (Modena)
book: Abstracts - ()

11573/235905 - 2005 - Dihalo Indolyl Aryl Sulfones (IASs) Highly Active In Vitro Against HIV-1 WT and Variants Carrying NNRTI Resistance Mutations.
De Martino, G.; La Regina, Giuseppe; Ragno, Rino; Coluccia, Antonio; Maga, G.; Artico, Marino; Silvestri, Romano - 04a Atto di comunicazione a congresso
conference: 20th International Congress of Heterocyclic Chemistry (Palermo)
book: Abstracts - ()

11573/359603 - 2005 - Docking and 3-D QSAR Studies on Indolyl Aryl Sulfones. Binding Mode Exploration at the HIV-1 Reverse Transcriptase Non-Nucleoside Binding Site and Design of Highly Active N-(2-Hydroxyethyl)carboxamide and N-(2-Hydroxyethyl)carbohydrazide Derivatives.
Ragno, Rino; Artico, Marino; De Martino, G.; La Regina, Giuseppe; Coluccia, Antonio; Di Pasquali, A.; Silvestri, Romano - 01a Articolo in rivista
paper: JOURNAL OF MEDICINAL CHEMISTRY (Washington, DC: American Chemical Society) pp. 213-223 - issn: 0022-2623 - wos: WOS:000226212900021 (74) - scopus: 2-s2.0-12144279076 (86)

11573/360936 - 2004 - Arylthioindoles, potent inhibitors of tubulin polymerization.
De Martino, G.; La Regina, Giuseppe; Coluccia, Antonio; Edler, M. C.; Barbera, M. C.; Brancale, A.; Wilcox, E.; Hamel, E.; Artico, Marino; Silvestri, Romano - 01a Articolo in rivista
paper: JOURNAL OF MEDICINAL CHEMISTRY (Washington, DC: American Chemical Society) pp. 6120-6123 - issn: 0022-2623 - wos: WOS:000225409400003 (282) - scopus: 2-s2.0-10044236627 (296)

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