ANTONIO CAPALBO

Dottore di ricerca

ciclo: XXXIII


supervisore: Prof. Rita Canipari
relatore: Antonio Capalbo

Titolo della tesi: Non-invasive analysis of the embryonic genome for the development of improved preimplantation genetic testing (PGT) protocols

To characterize cell-free DNA origin and determine whether spent blastocyst medium (SBM) is a suitable template for non-invasive genomic assessment of IV§F–generated embryos. As preliminary phase, the origin of aneuploidy was investigated in human blastocysts by using NGS analysis on multiple TE and ICM biopsies from the same embryo. We concluded that whole chromosome aneuploidies are mostly meiotic in origin and can be targeted from SBM samples. On the contrary, we provide definitive evidence about the preferential mitotic nature of segmental aneuploidies, making them as an unsuitable target for SBM analysis. Next, we have assessed the concordance rate and genotyping accuracy of SBM vs embryonic biopsies under standard genetic and IVF laboratory protocols. Under this setting we have highlighted poor predictive performance of embryonic culture media in defining the genetic and chromosomal constitution of the embryo. In particular, In PGT-M tests, for BF and SBM, 2.9% and 20.8% of all samples, respectively, produced a diagnosis concordant with the corresponding TE (n=2 of 69 and 15 of 72, respectively). In PGT-A tests, BF analysis showed high amplification failure rates (65.2%) and an overall concordance rate of 37.5% among amplified samples. After improving embryo culture conditions and genetic protocols for the analysis of SBM samples, we could obtained concordant chromosome analysis between SBM and their relative TE biopsies as high as 87% (N=115) from day 6 embryos in a prospective pilot multicenter study. With the new optimized strategy, a prospective multicenter trial on 1301 paired TE and SBM sample was performed. Results have confirmed high concordance and reproducibility among the IVF centers involved. Improvement in embryo culture and genetic technologies have shown the possibility to utilize SBM for non-invasive assessment of embryonic genetics by the analysis of cfDNA. Future clinical trials are warranted to assess clinical utility of the novel strategy that holds the potentiality of becoming a milestone achievement in the field of preimplantation genetics.

Produzione scientifica

11573/1713652 - 2023 - Implementing preconception expanded carrier screening in a universal health care system. A model-based cost-effectiveness analysis
Busnelli, Andrea; Ciani, Oriana; Caroselli, Silvia; Figliuzzi, Matteo; Poli, Maurizio; Levi-Setti, Paolo Emanuele; Tarricone, Rosanna; Capalbo, Antonio - 01a Articolo in rivista
rivista: GENETICS IN MEDICINE (New York: Elsevier Baltimore MD: Williams & Wilkins) pp. 1-15 - issn: 1098-3600 - wos: WOS:001062903800001 (2) - scopus: 2-s2.0-85170274034 (4)

11573/1716367 - 2021 - Technical factors to consider when developing an expanded carrier screening platform
Fabiani, Marco; Cogo, Francesco; Poli, Maurizio; Capalbo, Antonio - 01g Articolo di rassegna (Review)
rivista: CURRENT OPINION IN OBSTETRICS & GYNECOLOGY (Lippincott, Williams & Wilkins:530 Walnut Street:Philadelphia, PA 19106:(800)638-3030, (301)223-2300, EMAIL: orders@lww.com, INTERNET: http://www.lww.com, Fax: (301)223-2320, (301)223-2320) pp. 178-183 - issn: 1040-872X - wos: WOS:000643795300005 (1) - scopus: 2-s2.0-85105763336 (3)

11573/1383455 - 2020 - Incidence, origin, and predictive model for the detection and Clinical Management of segmental aneuploidies in human embryos
Girardi, Laura; Serdarogullari, Munevver; Patassini, Cristina; Poli, Maurizio; Fabiani, Marco; Caroselli, Silvia; Coban, Onder; Findikli, Necati; Boynukalin, Fazilet Kubra; Bahceci, Mustafa; Chopra, Rupali; Canipari, Rita; Cimadomo, Danilo; Rienzi, Laura; Ubaldi, Filippo; Hoffmann, Eva; Rubio, Carmen; Simon, Carlos; Capalbo, Antonio - 01a Articolo in rivista
rivista: AMERICAN JOURNAL OF HUMAN GENETICS (University of Chicago Press:PO Box 37005, Journals Division:Chicago, IL 60637:(877)705-1878, (877)705-1878, (773)753-2247, EMAIL: subscriptions@press.uchicago.edu, INTERNET: http://www.press.uchicago.edu, Fax: (877)705-1879, (773)753-0811) pp. 525-534 - issn: 0002-9297 - wos: WOS:000523306000009 (60) - scopus: 2-s2.0-85082592626 (63)

11573/1337526 - 2019 - Optimizing clinical exome design and parallel gene-testing for recessive genetic conditions in preconception carrier screening: Translational research genomic data from 14,125 exomes
Capalbo, A.; Valero, R. A.; Jimenez-Almazan, J.; Pardo, P. M.; Fabiani, M.; Jimenez, D.; Simon, C.; Rodriguez, J. M. - 01a Articolo in rivista
rivista: PLOS GENETICS (San Francisco, CA : Public Library of Science, c2005-) pp. e1008409- - issn: 1553-7390 - wos: WOS:000503176900019 (17) - scopus: 2-s2.0-85073577764 (16)

11573/1716723 - 2019 - Optimizing clinical exome design and parallel gene-testing for recessive genetic conditions in preconception carrier screening: Translational research genomic data from 14,125 exomes
Capalbo, Antonio; Valero, Roberto Alonso; Jimenez-Almazan, Jorge; Pardo, Pere Mir; Fabiani, Marco; Jiménez, David; Simon, Carlos; Rodriguez, Julio Martin - 01a Articolo in rivista
rivista: PLOS GENETICS (San Francisco, CA : Public Library of Science, c2005-) pp. - - issn: 1553-7404 - wos: WOS:000503176900019 (47) - scopus: 2-s2.0-85073577764 (48)

11573/1311293 - 2019 - Definition and validation of a custom protocol to detect miRNAs in the spent media after blastocyst culture: searching for biomarkers of implantation
Cimadomo, Danilo; Rienzi, Laura; Giancani, Adriano; Alviggi, Erminia; Dusi, Ludovica; Canipari, Rita; Noli, Laila; Ilic, Dusko; Khalaf, Yacoub; Ubaldi, Filippo Maria; Capalbo, Antonio - 01a Articolo in rivista
rivista: HUMAN REPRODUCTION (Oxford University Press:Journals Department, Great Clarendon Street, Oxford OX2 6DP United Kingdom:011 44 1865 556767, EMAIL: jnlorders@oup.co.uk, INTERNET: http://www.oup.co.uk, Fax: 011 44 1865 267485) pp. 1746-1761 - issn: 0268-1161 - wos: WOS:000493096600013 (21) - scopus: 2-s2.0-85072057066 (27)

11573/1337514 - 2019 - Chromosome errors in human eggs shape natural fertility over reproductive life span
Gruhn, J. R.; Zielinska, A. P.; Shukla, V.; Blanshard, R.; Capalbo, A.; Cimadomo, D.; Nikiforov, D.; Chan, A. C. -H.; Newnham, L. J.; Vogel, I.; Scarica, C.; Krapchev, M.; Taylor, D.; Kristensen, S. G.; Cheng, J.; Ernst, E.; Bjorn, A. -M. B.; Colmorn, L. B.; Blayney, M.; Elder, K.; Liss, J.; Hartshorne, G.; Grondahl, M. L.; Rienzi, L.; Ubaldi, F.; Mccoy, R.; Lukaszuk, K.; Andersen, C. Y.; Schuh, M.; Hoffmann, E. R. - 01a Articolo in rivista
rivista: SCIENCE (American Association for the Advancement of Science:1200 New York Avenue Northwest:Washington, DC 20005:(202)326-6417, (202)326-6400, EMAIL: membership@aaas.org, INTERNET: http://www.aaas.org, Fax: (202)842-1065, (202)842-1065) pp. 1466-1469 - issn: 0036-8075 - wos: WOS:000488838600051 (228) - scopus: 2-s2.0-85072782307 (247)

11573/1341044 - 2019 - Time of morulation and trophectoderm quality are predictors of a live birth after euploid blastocyst transfer: a multicenter study
Rienzi, L.; Cimadomo, D.; Delgado, A.; Minasi, M. G.; Fabozzi, G.; Gallego, R. D.; Stoppa, M.; Bellver, J.; Giancani, A.; Esbert, M.; Capalbo, A.; Remohi, J.; Greco, E.; Ubaldi, F. M.; Meseguer, M. - 01a Articolo in rivista
rivista: FERTILITY AND STERILITY (Usa: Elsevier -Highway, Birmingham, AL: American Society for Reproductive Medicine) pp. 1080-1093.e1 - issn: 0015-0282 - wos: WOS:000502762700024 (18) - scopus: 2-s2.0-85076240947 (27)

11573/1337528 - 2019 - Embryonic cell-free DNA versus trophectoderm biopsy for aneuploidy testing: concordance rate and clinical implications
Rubio, Carmen; Rienzi, Laura; Navarro-Sánchez, Luis; Cimadomo, Danilo; María García-Pascual, Carmen; Albricci, Laura; Soscia, Daria; Valbuena, Diana; Capalbo, Antonio; Ubaldi, Filippo; Simón, Carlos - 01a Articolo in rivista
rivista: FERTILITY AND STERILITY (Usa: Elsevier -Highway, Birmingham, AL: American Society for Reproductive Medicine) pp. 510-519 - issn: 0015-0282 - wos: WOS:000482213400025 (74) - scopus: 2-s2.0-85066944627 (88)

11573/1246631 - 2019 - An integrated investigation of oocyte developmental competence: expression of key genes in human cumulus cells, morphokinetics of early divisions, blastulation, and euploidy
Scarica, C.; Cimadomo, D.; Dovere, L.; Giancani, A.; Stoppa, M.; Capalbo, A.; Ubaldi, F. M.; Rienzi, L.; Canipari, R. - 01a Articolo in rivista
rivista: JOURNAL OF ASSISTED REPRODUCTION AND GENETICS (Plenum Press:Book Customer Service, 233 Spring Street:New York, NY 10013:(212)620-8471, (212)620-8000, EMAIL: info@plenum.com, INTERNET: http://www.plenum.com, Fax: (212)807-1047) pp. 875-887 - issn: 1058-0468 - wos: WOS:000469445600008 (26) - scopus: 2-s2.0-85060960532 (25)

11573/1173223 - 2018 - Diagnostic efficacy of blastocoel fluid and spent media as sources of DNA for preimplantation genetic testing in standard clinical conditions
Capalbo, A; Romanelli, V; Patassini, C; Poli, M; Girardi, L; Giancani, A; Stoppa, M; Cimadomo, D; Ubaldi, Fm; Rienzi, L. - 01a Articolo in rivista
rivista: FERTILITY AND STERILITY (Usa: Elsevier -Highway, Birmingham, AL: American Society for Reproductive Medicine) pp. 870-879.e5 - issn: 0015-0282 - wos: WOS:000446885700024 (44) - scopus: 2-s2.0-85054465591 (48)

11573/1183954 - 2018 - Erratum to: Segregation of mitochondrial DNA heteroplasmy through a developmental genetic bottleneck in human embryos (Nature Cell Biology, (2018), 20, 2, (144-151), 10.1038/s41556-017-0017-8)
Floros, Vasileios I.; Pyle, Angela; Dietmann, Sabine; Wei, Wei; Tang, Walfred W. C.; Irie, Naoko; Payne, Brendan; Capalbo, Antonio; Noli, Laila; Coxhead, Jonathan; Hudson, Gavin; Crosier, Moira; Strahl, Henrik; Khalaf, Yacoub; Saitou, Mitinori; Ilic, Dusko; Surani, M. Azim; Chinnery, Patrick F. - 01a Articolo in rivista
rivista: NATURE CELL BIOLOGY (Nature America Incorporated:345 Park Avenue South, 6th Floor:New York, NY 10010:(888)331-6288, EMAIL: institutions@natureny.com, INTERNET: http://www.nature.com, Fax: (212)689-9108) pp. 991-991 - issn: 1465-7392 - wos: WOS:000440057000021 (1) - scopus: 2-s2.0-85045767927 (2)

11573/1189480 - 2018 - Prevalence of XXY karyotypes in human blastocysts: multicentre data from 7549 trophectoderm biopsies obtained during preimplantation genetic testing cycles in IVF
Mazzilli, Rossella; Cimadomo, Danilo; Rienzi, Laura; Capalbo, Antonio; Levi Setti, Paolo Emanuele; Livi, Claudia; Vizziello, Damiano; Foresta, Carlo; Ferlin, Alberto; Ubaldi, Filippo Maria - 01a Articolo in rivista
rivista: HUMAN REPRODUCTION (Oxford University Press:Journals Department, Great Clarendon Street, Oxford OX2 6DP United Kingdom:011 44 1865 556767, EMAIL: jnlorders@oup.co.uk, INTERNET: http://www.oup.co.uk, Fax: 011 44 1865 267485) pp. 1355-1363-1363 - issn: 0268-1161 - wos: WOS:000438335300020 (10) - scopus: 2-s2.0-85057715073 (11)

11573/1173220 - 2018 - Biochemical pregnancy loss after frozen embryo transfer seems independent of embryo developmental stage and chromosomal status
Vaiarelli, A; Cimadomo, D; Patrizio, P; Venturella, R; Orlando, G; Soscia, D; Giancani, A; Capalbo, A; Rienzi, L; Ubaldi, Fm. - 01a Articolo in rivista
rivista: REPRODUCTIVE BIOMEDICINE ONLINE ([Cambridge] : Reproductive Healthcare Limited, 2000-) pp. 349-357 - issn: 1472-6483 - wos: WOS:000446886200010 (21) - scopus: 2-s2.0-85052152322 (21)

11573/1118428 - 2017 - Human female meiosis revised: New insights into the mechanisms of chromosome segregation and aneuploidies from advanced genomics and time-lapse imaging
Capalbo, Antonio; Hoffmann, Eva R.; Cimadomo, Danilo; Ubaldi, Filippo Maria; Rienzi, Laura - 01a Articolo in rivista
rivista: HUMAN REPRODUCTION UPDATE (Oxford University Press:Journals Department, Great Clarendon Street, Oxford OX2 6DP United Kingdom:011 44 1865 556767, EMAIL: jnlorders@oup.co.uk, INTERNET: http://www.oup.co.uk, Fax: 011 44 1865 267485) pp. 706-722 - issn: 1355-4786 - wos: WOS:000413533000005 (100) - scopus: 2-s2.0-85034421478 (105)

11573/1015148 - 2017 - Abnormally fertilized oocytes can result in healthy live births: improved genetic technologies for preimplantation genetic testing can be used to rescue viable embryos in in vitro fertilization cycles
Capalbo, Antonio; Treff, Nathan; Cimadomo, Danilo; Tao, Xin; Ferrero, Susanna; Vaiarelli, Alberto; Colamaria, Silvia; Maggiulli, Roberta; Orlando, Giovanna; Scarica, Catello; Ubaldi, Filippo Maria; Rienzi, Laura; Delahunta, Richard Scott - 01a Articolo in rivista
rivista: FERTILITY AND STERILITY (Usa: Elsevier -Highway, Birmingham, AL: American Society for Reproductive Medicine) pp. 1007-1015 - issn: 0015-0282 - wos: WOS:000417316900022 (26) - scopus: 2-s2.0-85029478687 (27)

11573/1118442 - 2017 - Prevention of neural tube defects and maternal gestational diabetes through the inositol supplementation: preliminary results
Dell'edera, D; Sarlo, F; Allegretti, A; Epifania, A A; Simone, F; Lupo, M G; Benedetto, M; D'apice, M R; Capalbo, A - 01a Articolo in rivista
rivista: EUROPEAN REVIEW FOR MEDICAL AND PHARMACOLOGICAL SCIENCES (Roma: Verduci publisher) pp. 3305-3311 - issn: 2284-0729 - wos: WOS:000411497900022 (6) - scopus: 2-s2.0-85051185505 (6)

11573/1015149 - 2017 - Preimplantation genetic diagnosis for aneuploidy testing in women older than 44 years: a multicenter experience
Ubaldi, Filippo Maria; Cimadomo, Danilo; Capalbo, Antonio; Vaiarelli, Alberto; Buffo, Laura; Trabucco, Elisabetta; Ferrero, Susanna; Albani, Elena; Rienzi, Laura; Levi Setti, Paolo E. - 01a Articolo in rivista
rivista: FERTILITY AND STERILITY (Usa: Elsevier -Highway, Birmingham, AL: American Society for Reproductive Medicine) pp. 1173-1180 - issn: 0015-0282 - wos: WOS:000402682300018 (52) - scopus: 2-s2.0-85017523594 (62)

11573/853032 - 2016 - Consistent and reproducible outcomes of blastocyst biopsy and aneuploidy screening across different biopsy practitioners: a multicentre study involving 2586 embryo biopsies
Capalbo, Antonio; Ubaldi, Filippo Maria; Cimadomo, Danilo; Maggiulli, Roberta; Patassini, Cristina; Dusi, Ludovica; Sanges, Federica; Buffo, Laura; Venturella, Roberta; Rienzi, Laura - 01a Articolo in rivista
rivista: HUMAN REPRODUCTION (Oxford University Press:Journals Department, Great Clarendon Street, Oxford OX2 6DP United Kingdom:011 44 1865 556767, EMAIL: jnlorders@oup.co.uk, INTERNET: http://www.oup.co.uk, Fax: 011 44 1865 267485) pp. 199-208-208 - issn: 0268-1161 - wos: WOS:000371148900024 (70) - scopus: 2-s2.0-84957598790 (80)

11573/853036 - 2016 - The impact of biopsy on human embryo developmental potential during preimplantation genetic diagnosis
Cimadomo, Danilo; Ubaldi, Filippo Maria; Scarica, Catello; Palagiano, Antonio; Canipari, Rita; Rienzi, Laura; Capalbo, Antonio - 01g Articolo di rassegna (Review)
rivista: BIOMED RESEARCH INTERNATIONAL ([London]: [Hindawi] Cairo: Hindawi Publishing Corporation) pp. 1-10 - issn: 2314-6133 - wos: WOS:000369690100001 (120) - scopus: 2-s2.0-84958073835 (152)

11573/902743 - 2016 - Electronic witness system in IVF—patients perspective
Forte, Marina; Faustini, Federica; Maggiulli, Roberta; Scarica, Catello; Romano, Stefania; Ottolini, Christian; Farcomeni, Alessio; Palagiano, Antonio; Capalbo, Antonio; Ubaldi, Filippo Maria; Rienzi, Laura - 01a Articolo in rivista
rivista: JOURNAL OF ASSISTED REPRODUCTION AND GENETICS (Plenum Press:Book Customer Service, 233 Spring Street:New York, NY 10013:(212)620-8471, (212)620-8000, EMAIL: info@plenum.com, INTERNET: http://www.plenum.com, Fax: (212)807-1047) pp. 1215-1222 - issn: 1058-0468 - wos: WOS:000382681700013 (10) - scopus: 2-s2.0-84978168232 (16)

11573/932326 - 2016 - Human Embryos Created by Embryo Splitting Secrete Significantly Lower Levels of miRNA-30c
Noli, Laila; Capalbo, Antonio; Dajani, Yaser; Cimadomo, Danilo; Bvumbe, Jean; Rienzi, Laura; Ubaldi, Filippo Maria; Ogilvie, Caroline; Khalaf, Yacoub; Ilic, Dusko - 01a Articolo in rivista
rivista: STEM CELLS AND DEVELOPMENT (MARY ANN LIEBERT INC, 2 MADISON AVENUE, LARCHMONT, USA, NY, 10538) pp. 1853-1862 - issn: 1547-3287 - wos: WOS:000389312100002 (14) - scopus: 2-s2.0-85003874987 (17)

11573/932330 - 2016 - Implementing PGD/PGD-A in IVF clinics: considerations for the best laboratory approach and management
Romanelli, Valeria; Cimadomo, Danilo; Girardi, Laura; Stoppa, Marta; Dovere, Lisa; Dell’Edera, Domenico; Ubaldi, Filippo Maria; Rienzi, Laura; Capalbo, Antonio - 01a Articolo in rivista
rivista: JOURNAL OF ASSISTED REPRODUCTION AND GENETICS (Plenum Press:Book Customer Service, 233 Spring Street:New York, NY 10013:(212)620-8471, (212)620-8000, EMAIL: info@plenum.com, INTERNET: http://www.plenum.com, Fax: (212)807-1047) pp. 1279-1286 - issn: 1058-0468 - wos: WOS:000386373200005 (26) - scopus: 2-s2.0-84978833039 (32)

11573/872506 - 2016 - Follicular versus luteal phase ovarian stimulation during the same menstrual cycle (DuoStim) in a reduced ovarian reserve population results in a similar euploid blastocyst formation rate: new insight in ovarian reserve exploitation
Ubaldi, Filippo Maria; Vaiarelli, Alberto; Cimadomo, Danilo; Colamaria, Silvia; Alviggi, Carlo; Trabucco, Elisabetta; Venturella, Roberta; Vajta, Gábor; Rienzi, Laura; Capalbo, Antonio - 01a Articolo in rivista
rivista: FERTILITY AND STERILITY (Usa: Elsevier -Highway, Birmingham, AL: American Society for Reproductive Medicine) pp. 1488-1495 - issn: 0015-0282 - wos: WOS:000377290900020 (164) - scopus: 2-s2.0-84961992386 (196)

11573/932328 - 2016 - Pre-implantation genetic testing in ART: who will benefit and what is the evidence?
Vaiarelli, Alberto; Cimadomo, Danilo; Capalbo, Antonio; Orlando, Giovanna; Sapienza, Fabio; Colamaria, Silvia; Palagiano, Antonio; Bulletti, Carlo; Rienzi, Laura; Ubaldi, Filippo Maria - 01a Articolo in rivista
rivista: JOURNAL OF ASSISTED REPRODUCTION AND GENETICS (Plenum Press:Book Customer Service, 233 Spring Street:New York, NY 10013:(212)620-8471, (212)620-8000, EMAIL: info@plenum.com, INTERNET: http://www.plenum.com, Fax: (212)807-1047) pp. 1273-1278 - issn: 1058-0468 - wos: WOS:000386373200004 (26) - scopus: 2-s2.0-84982883852 (30)

11573/853046 - 2015 - Blastocyst morphology does not significantly increase the selection between euploid blastocysts in frozen embryo transfer cycles: evidences from a prospective non-selection study
Capalbo, Antonio; Cimadomo, Danilo; Patassini, Cristina; Poggiana, Cristina; Scepi, Emiliano; Stoppa, Marta; Dovere, Lisa; Dusi, Ludovica; Ubaldi, Filippo Maria; Rienzi, Laura - 04d Abstract in atti di convegno
rivista: HUMAN REPRODUCTION (Oxford University Press:Journals Department, Great Clarendon Street, Oxford OX2 6DP United Kingdom:011 44 1865 556767, EMAIL: jnlorders@oup.co.uk, INTERNET: http://www.oup.co.uk, Fax: 011 44 1865 267485) pp. - - issn: 0268-1161 - wos: (0) - scopus: (0)

11573/614648 - 2015 - No evidence of association between blastocyst aneuploidy and morphokinetic assessment in a selected population of poor-prognosis patients: a longitudinal cohort study
Rienzi, L.; Capalbo, A.; Stoppa, M.; Romano, S.; Maggiulli, R.; Albricci, L.; Scarica, C.; Farcomeni, Alessio; Vajta, G.; Ubaldi, F. M. - 01a Articolo in rivista
rivista: REPRODUCTIVE BIOMEDICINE ONLINE ([Cambridge] : Reproductive Healthcare Limited, 2000-) pp. 57-66 - issn: 1472-6483 - wos: WOS:000347102400009 (96) - scopus: 2-s2.0-84920121039 (115)

11573/853078 - 2015 - Reduction of multiple pregnancy rate in advanced maternal age population after the introduction of an elective single embryo transfer policy: a pre- and post- intervention study
Ubaldi, Filippo Maria; Capalbo, Antonio; Colamaria, Silvia; Maggiulli, Roberta; Sapienza, Fabio; Romano, Stefania; Ferrero, Susanna; Scarica, Catello; Giuliani, Maddalena; Gravotta, Enrica; Vaiarelli, Alberto; Albricci, Laura; Ievoli, Elena; Cimadomo, Danilo; Rienzi, Laura - 04d Abstract in atti di convegno
rivista: HUMAN REPRODUCTION (Oxford University Press:Journals Department, Great Clarendon Street, Oxford OX2 6DP United Kingdom:011 44 1865 556767, EMAIL: jnlorders@oup.co.uk, INTERNET: http://www.oup.co.uk, Fax: 011 44 1865 267485) pp. - - issn: 0268-1161 - wos: WOS:000359740302228 (0) - scopus: (0)

11573/853041 - 2014 - Secreted miRNAs can be profiled with high accuracy and reproducibility from blastocyst spent culture media: a new potential biomarker for non-invasive embryo selection
Capalbo, Antonio; Noli, Laila; Ilic, Dusko; Cimadomo, Danilo; Khalaf, Yacoub; Ubaldi, Filippo Maria; Rienzi, Laura - 04d Abstract in atti di convegno
rivista: HUMAN REPRODUCTION (Oxford University Press:Journals Department, Great Clarendon Street, Oxford OX2 6DP United Kingdom:011 44 1865 556767, EMAIL: jnlorders@oup.co.uk, INTERNET: http://www.oup.co.uk, Fax: 011 44 1865 267485) pp. - - issn: 0268-1161 - wos: WOS:000359745300100 (0) - scopus: (0)

11573/434020 - 2012 - The 312N variant of the luteinizing hormone/choriogonadotropin receptor gene (LHCGR) confers up to 2.7-fold increased risk of polycystic ovary syndrome in a Sardinian population
Capalbo, A.; Sagnella, F.; Apa, R.; Fulghesu, A. M.; Lanzone, A.; Morciano, A.; Farcomeni, Alessio; Gangale, M. F.; Moro, F.; Martinez, D.; Spettu, F.; Cappai, A.; Carcassi, C.; Neri, G.; Tiziano, F. D. - 01a Articolo in rivista
rivista: CLINICAL ENDOCRINOLOGY (MALDEN, USA, MA: WILEY-BLACKWELL United Kingdom: Blackwell Science Limited) pp. 113-119 - issn: 0300-0664 - wos: WOS:000304864700020 (38) - scopus: 2-s2.0-84862012197 (47)

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