Phd in MORPHOGENESIS AND TISSUE ENGINEERING

email: angela.catizone@uniroma1.it
phone: 26885

room: 29 A

PERSONAL INFORMATION : Catizone Angiolina

Affiliation
University of Rome “Sapienza “
Department of Anatomy Histology Forensic Medicine and Orthopedics
Address: Via Antonio Scarpa14/16 00161 Rome Italy

+390649766885 +

angela.catizone@unioma1.it

https://corsidilaurea.uniroma1.it/it/users/angelacatizoneuniroma1it
• ORCID: 0000-0002-7836-9495
• Google scholar profile: https://scholar.google.com/citations?hl=it&user=5Aie9ZQAAAAJ
• Scopus: https://www.scopus.com/authid/detail.uri?authorId=6601944290
F | 11/09/1958 | Nationality : Italian


Enterprise University EPR
☐ Management Level
☐ Full professor
☐ Research Director and 1st level Technologist / First Researcher and 2nd level Technologist / Principal Investigator
☐ Mid-Management Level
☒ Associate Professor
☐ Level III Researcher and Technologist

☐ Employee / worker level
☐ Researcher and Technologist of IV, V, VI and VII level / Technical collaborator ☐ Researcher and Technologist of IV, V, VI and VII level / Technical collaborator


SSD (BIO/17)


WORK EXPERIENCE

1995- 2021 Research Associate Department of Anatomy Histology Forensic Medicine and Orthopedics University of Rome “Sapienza”

2021- to present: Associate professor of Histology and embryology Department of Anatomy Histology Forensic Medicine and Orthopedics University of Rome “



EDUCATION AND TRAINING
1993 PhD in “Biotechnology and Biometrics” University of “L’Aquila”
1987 Specialization in “Medical Genetics” University of Rome; 70/70 cum laude
1983 Degree in “Biological Sciences” University of Rome; 110/110 cum laude
Replace with EQF (or other) level if relevant

WORK ACTIVITIES

Main projects

- Biology and pathology of cell-cell, cell-matrix interactions
- Role of growth factors in gonadal development and differentiation.
- Signal transduction and molecular pathways involved in carcinogenesis
- Cellular interactions in the control of folliculogenesis and oocyte maturation.
- Role of molecules in prostate and testis cancers as potential markers for monitoring stem cell plasticity
- Role in the regulation of the methylation state of the promoters of genes involved in oncogenesis.
- Effects of microgravity on testicular function.
- Effect of microgravity on the organization of the cytoskeleton in different normal and tumour cells lines.
- Effects of microgravity exposure on reactive oxygen species levels

Supervisor of degree thesis and PhD thesis
Editorial activity
Guest editor “International Journal of Cell Biology” Special Issue on The Hepatocyte Growth Factor/c-Met System: Its Role in Development, Homeostasis, and Diseases

Invited presentations
Speaker : Il Percorso Diagnostico Multidisciplinare Del Feto Con Patologia Genetico-Malformativa : Anomalie Del Sistema Genetico Urinario:Dalla Genetica Alla Clinica Roma, 12-13 Maggio 2016

Speaker 16th European Workshop On Molecular And Cellular Endocrinology Of The Testis La Biodola Isola d'Elba Italy 8-12- Maggio 2010

Grants: " ASI Accordo attuativo 2020-24-HH.0 CUPF82F20000180005": Role: Principal Investigator
"Asi accordo attuativo 2014-010-R.0”. Role: Investigator
From 1999 – to present: Grants from “Ateneo Sapienza “ Role: Principal Investigator/investigator

ADDITIONAL INFORMATION

Publications
Total number of publications in peer-review journals :88
Total number of publications in journals belonging to the first Scopus quartile (or in A class)

1. Berardini M, ET AL., . Simulated Microgravity Exposure Induces Antioxidant Barrier Deregulation and Mitochondria Enlargement in TCam-2 Cell Spheroids. Cells. 2023 Aug 19;12(16):2106. doi: 10.3390/cells12162106. PMID: 37626916; PMCID: PMC10453291.
2. Gesualdi L, ET AL., ERK Signaling Pathway Is Constitutively Active in NT2D1 Non-Seminoma Cells and Its Inhibition Impairs Basal and HGF-Activated Cell Proliferation. Biomedicines. 2023 Jul 4;11(7):1894. doi: 10.3390/biomedicines11071894. PMID: 37509533; PMCID: PMC10377482
3. Ricci G, ET AL., KISS1R and ANKRD31 Cooperate to Enhance Leydig Cell Gene Expression via the Cytoskeletal-Nucleoskeletal Pathway. Front Cell Dev Biol. 2022 Jun 23;10:877270. doi: 10.3389/fcell.2022.877270. PMID: 35813201; PMCID: PMC9260857
4. Fedeli V, et al. (2022) Microgravity Modifies the Phenotype of Fibroblast and Promotes Remodeling of the Fibroblast–Keratinocyte Interaction in a 3D Co-Culture Model. International Journal of Molecular Sciences 23(4).
5. Ricci G, et al. (2021) Article microgravity induces transient emt in human keratinocytes by early down-regulation of e-cadherin and cell-adhesion remodeling. Applied Sciences (Switzerland) 11(1):1-19.
6. Proietti S, et al. (2021) Zebrafish embryo extracts enhance 5-FU anti-cancer effects upon breast cancer cells. European Review for Medical and Pharmacological Sciences 25(8):3235-3245.
7. Monti N, et al. (2021) Survival pathways are differently affected by microgravity in normal and cancerous breast cells. International Journal of Molecular Sciences 22(2):1-26.
8. Minini M, et al. (2021) miR-125a-5p impairs the metastatic potential in breast cancer via IP6K1 targeting. Cancer Letters 520:48-56.
9. Fattore L, et al. (2021) The Promise of Liquid Biopsy to Predict Response to Immunotherapy in Metastatic Melanoma. Frontiers in Oncology 11.
10. Gesualdi L, et al. (2020) The PI3K/AKT pathway is activated by HGF in NT2D1 non‐seminoma cells and has a role in the modulation of their malignant behavior. International Journal of Molecular Sciences 21(22):1-22.
11. Catizone A, et al. (2020) Microgravity-induced cell-to-cell junctional contacts are counteracted by antioxidant compounds in TCAM-2 seminoma cells. Applied Sciences (Switzerland) 10(22):1-16.
12. Belviso I, et al. (2020) Decellularized Human Dermal Matrix as a Biological Scaffold for Cardiac Repair and Regeneration. Frontiers in Bioengineering and Biotechnology 8.
13. Proietti S, et al. (2019) Active fraction from embryo fish extracts induces reversion of the malignant invasive phenotype in breast cancer through down-regulation of tctp and modulation of e-cadherin/β-catenin pathway. International Journal of Molecular Sciences 20(9).
14. Po A, et al. (2019) Phenotypic transitions enacted by simulated microgravity do not alter coherence in gene transcription profile. NPJ microgravity 5(1).
15. Leonetti E, et al. (2019) c-src recruitment is involved in c-MET-mediated malignant behaviour of NT2D1 non-seminoma cells. International Journal of Molecular Sciences 20(2).
16. Scicchitano BM, et al. (2018) Levetiracetam enhances the temozolomide effect on glioblastoma stem cell proliferation and apoptosis. Cancer cell international 18(1).
17. Scheri KC, et al. (2018) Correction: C-MET receptor as potential biomarker and target molecule for malignant testicular germ cell tumors (Oncotarget (2018) 9 (31842-31860) DOI: 10.18632/oncotarget.25867). Oncotarget 9(89):36049.
18. Scheri KC, et al. (2018) c-MET receptor as potential biomarker and target molecule for malignant testicular germ cell tumors. Oncotarget 9(61):31842-31860.
19. Proietti S, et al. (2018) Increase in motility and invasiveness of MCF7 cancer cells induced by nicotine is abolished by melatonin through inhibition of ERK phosphorylation. Journal of pineal research 64(4).
20. Dobrowolny G, et al. (2018) Muscle Expression of SOD1 G93A Triggers the Dismantlement of Neuromuscular Junction via PKC-Theta. Antioxidants and Redox Signaling 28(12):1105-1119.
21. Dinicola S, et al. (2018) Nicotine increases colon cancer cell migration and invasion through epithelial to mesenchymal transition (EMT): COX-2 involvement. Journal of Cellular Physiology 233(6):4935-4948.
22. Ranieri D, et al. (2017) Simulated microgravity triggers epithelial mesenchymal transition in human keratinocytes. Scientific reports 7(1).
23. Noto A, et al. (2017) Stearoyl-CoA-desaturase 1 regulates lung cancer stemness via stabilization and nuclear localization of YAP/TAZ. Oncogene 36(32):4573-4584.
24. Morabito C, et al. (2017) Transient increases in intracellular calcium and reactive oxygen species levels in TCam-2 cells exposed to microgravity. Scientific reports 7(1).
25. Borroni E, et al. (2017) Tumor targeting by lentiviral vectors combined with magnetic nanoparticles in mice. Acta biomaterialia 59:303-316.
26. Morabito C, et al. (2016) Responses of peripheral blood mononuclear cells to moderate exercise and hypoxia. Scandinavian Journal of Medicine and Science in Sports 26(10):1188-1199.
27. Fabrizi C, et al. (2016) Impairment of the autophagic flux in astrocytes intoxicated by trimethyltin. Neurotoxicology 52:12-22.
28. Dinicola S, et al. (2016) Paradoxical E-cadherin increase in 5FU-resistant colon cancer is unaffected during mesenchymal-epithelial reversion induced by γ-secretase inhibition. Life sciences 145:174-183.
29. Dinicola S, et al. (2016) Inositol induces mesenchymal-epithelial reversion in breast cancer cells through cytoskeleton rearrangement. Experimental cell research 345(1):37-50.
30. De Matteis G, et al. (2016) Evaluation of leptin receptor expression on buffalo leukocytes. Veterinary immunology and immunopathology 177:16-23.
31. Valenti P, Catizone A, Frioni A, & Berlutti F (2015) Lactoferrin and Cystic Fibrosis Airway Infection. Diet and Exercise in Cystic Fibrosis), pp 259-270.
32. Pelosi L, et al. (2015) Increased levels of interleukin-6 exacerbate the dystrophic phenotype in mdx mice. Human molecular genetics 24(21):6041-6053.
33. Pelosi L, et al. (2015) Functional and Morphological Improvement of Dystrophic Muscle by Interleukin 6 Receptor Blockade. EBioMedicine 2(4):285-293.
34. Dinicola S, et al. (2015) Multiwalled carbon nanotube buckypaper induces cell cycle arrest and apoptosis in human leukemia cell lines through modulation of AKT and MAPK signaling pathways. Toxicology in Vitro 29(7):1298-1308.
35. Catizone A, et al. (2015) HGF modulates actin cytoskeleton remodeling and contraction in testicular myoid cells. Biomedicines 3(1):89-109.
36. Caruso M, et al. (2015) R-spondin 1/Dickkopf-1/beta-catenin machinery is involved in testicular embryonic angiogenesis. PLoS ONE 10(4).
37. Visentini M, et al. (2014) Dysregulated extracellular signal-regulated kinase signaling associated with impaired B-cell receptor endocytosis in patients with common variable immunodeficiency. Journal of Allergy and Clinical Immunology 134(2):401-410.e410.
38. Ricci G & Catizone A (2014) Pleiotropic activities of HGF/c-Met system in testicular physiology: Paracrine and endocrine implications. Frontiers in endocrinology 5(APR).
39. Ferranti F, et al. (2014) Cytoskeleton modifications and autophagy induction in TCam-2 Seminoma cells exposed to simulated microgravity. BioMed research international 2014.
40. Fabrizi C, et al. (2014) Lithium improves survival of PC12 pheochromocytoma cells in high-density cultures and after exposure to toxic compounds. International journal of cell biology.
41. Dinicola S, et al. (2014) Grape seed extract suppresses MDA-MB231 breast cancer cell migration and invasion. European journal of nutrition 53(2):421-431.
42. Rizzuto E, Catizone A, Musarò A, & Del Prete Z (2013) Dystrophic tendon functionality is recovered by muscle-specific expression of insulin-like growth factor in mdx mice. Journal of biomechanics 46(3):604-607.
43. Guastafierro T, et al. (2013) ADP-ribose polymer depletion leads to nuclear Ctcf re-localization and chromatin rearrangement. Biochemical Journal 449(3):623-630.
44. Ferranti F, et al. (2013) TCam-2 Seminoma Cells Exposed to Egg-Derived Microenvironment Modify Their Shape, Adhesive Pattern and Migratory Behaviour: A Molecular and Morphometric Analysis. PLoS ONE 8(10).
45. D'Anselmi F, et al. (2013) Microenvironment promotes tumor cell reprogramming in human breast cancer cell lines. PLoS ONE 8(12).
46. Ricci G, et al. (2012) Hepatocyte growth factor is a mouse fetal leydig cell terminal differentiation factor. Biology of reproduction 87(6).
47. Ferranti F, et al. (2012) Glial cell line-derived neurotrophic factor promotes invasive behaviour in testicular seminoma cells. International Journal of Andrology 35(5):758-768.
48. Ciccarone F, et al. (2012) Poly(ADP-ribosyl)ation Acts in the DNA Demethylation of Mouse Primordial Germ Cells Also with DNA Damage-Independent Roles. PLoS ONE 7(10).
49. Catizone A, et al. (2012) Hepatocyte growth factor (HGF) regulates blood-testis barrier (BTB) in adult rats. Molecular and Cellular Endocrinology 348(1):135-146.
50. Bellucci S, et al. (2012) Multiwalled carbon nanotubes-induced cytotoxic effects on human breast adenocarcinoma cell line. Proceedings of the International Semiconductor Conference, CAS, pp 37-42.
51. Valenti P, et al. (2011) Lactoferrin decreases inflammatory response by cystic fibrosis bronchial cells invaded with Burkholderia cenocepacia iron-modulated biofilm. International journal of immunopathology and pharmacology 24(4):1057-1068.
52. Toschi A, et al. (2011) Skeletal muscle regeneration in mice is stimulated by local overexpression of V1a-vasopressin receptor. Molecular Endocrinology 25(9):1661-1673.
53. Puddu P, et al. (2011) Bovine lactoferrin counteracts Toll-Like receptor mediated activation signals in antigen presenting cells. PLoS ONE 6(7).
54. Guglielmo MC, et al. (2011) The effect of hepatocyte growth factor on the initial stages of mouse follicle development. Journal of Cellular Physiology 226(2):520-529.
55. Carbonari M, Cibati M, Sette N, Catizone A, & Fiorilli M (2011) Measurement of Telomere Length Using PNA Probe by Cytometry. in Methods in cell biology, pp 189-202.
56. Bacalini MG, et al. (2011) Poly(ADP-ribosyl)ation affects stabilization of Che-1 protein in response to DNA damage. DNA repair 10(4):380-389.
57. Rizzuto E, Musarò A, Catizone A, & Del Prete Z (2010) Morpho-functional interaction between muscle and tendon in hypertrophic MLC/MIGF-1 MICE. ASME 2010 Summer Bioengineering Conference, SBC 2010, pp 927-928.
58. Chevanne M, et al. (2010) Inhibition of PARP activity by PJ-34 leads to growth impairment and cell death associated with aberrant mitotic pattern and nucleolar actin accumulation in M14 melanoma cell line. Journal of Cellular Physiology 222(2):401-410.
59. Catizone A, et al. (2010) Hepatocyte Growth Factor (HGF) modulates leydig cell extracellular matrix components. Journal of andrology 31(3):306-313.
60. Carbonari M, Mancaniello D, Cibati M, Catizone A, & Fiorilli M (2010) Improved procedure for the measurement of telomere length in whole cells by PNA probe and flow cytometry. Cell proliferation 43(6):553-561.
61. Berlutti F, et al. (2010) Streptococcus mutans and Streptococcus sobrinus are able to adhere and invade human gingival fibroblast cell line. International journal of immunopathology and pharmacology 23(4):1253-1260.
62. Rizzuto E, Musarò A, Catizone A, & Del Prete Z (2009) Measuring tendon properties in mdx mice: Cell viability and viscoelastic characteristics. Journal of biomechanics 42(14):2243-2248.
63. Ricci G, et al. (2009) Diabetic rat testes: Morphological and functional alterations. Andrologia 41(6):361-368.
64. Ricci G, Esposito R, Catizone A, & Galdieri M (2008) Direct effects of microgravity on testicular function: Analysis of hystological, molecular and physiologic parameters. Journal of endocrinological investigation 31(3):229-237.
65. Catizone A, Ricci G, & Galdieri M (2008) Hepatocyte growth factor modulates Sertoli-Sertoli tight junction dynamics. Journal of Cellular Physiology 216(1):253-260.
66. Del Bravo J, Catizone A, Ricci G, & Galdieri M (2007) Hepatocyte growth factor-modulated rat leydig cell functions. Journal of andrology 28(6):866-874.
67. Ricci G, Catizone A, & Galdieri M (2006) Expression and functional role of hepatocyte growth factor and its receptor (c-met) during fetal mouse testis development. Journal of Endocrinology 191(3):559-570.
68. Catizone A, Ricci G, Del Bravo J, & Galdieri M (2006) Hepatocyte growth factor modulates in vitro survival and proliferation of germ cells during postnatal testis development. Journal of Endocrinology 189(1):137-146.
69. Catizone A, Ricci G, & Galdieri M (2005) HGF and postnatal testis development. Molecular and Cellular Endocrinology 241(1-2):32-40.
70. Ricci G, Catizone A, & Galdieri M (2004) Embryonic mouse testis development: Role of platelet derived growth factor (PDGF-BB). Journal of Cellular Physiology 200(3):458-467.
71. Ricci G, Catizone A, Esposito R, & Galdieri M (2004) Microgravity effect on testicular functions. Journal of gravitational physiology : a journal of the International Society for Gravitational Physiology 11(2):P61-62.
72. Basciani S, et al. (2004) Expression of Platelet-Derived Growth Factor (PDGF) in the Epididymis and Analysis of the Epididymal Development in PDGF-A, PDGF-B, and PDGF Receptor β Deficient Mice. Biology of reproduction 70(1):168-177.
73. Cavazzini D, Catizone A, Galdieri M, & Ottonello S (2003) Vitamin A metabolism in cultured somatic cells from rat testis. Molecular and cellular biochemistry 252(1-2):165-171.
74. Ricci G, Catizone A, & Galdieri M (2002) Pleiotropic activity of hepatocyte growth factor during embryonic mouse testis development. Mechanisms of development 118(1-2):19-28.
75. Catizone A, Ricci G, & Galdieri M (2002) Functional role of hepatocyte growth factor receptor during sperm maturation. Journal of andrology 23(6):911-918.
76. Catizone A, Ricci G, & Galdieri M (2001) Expression and functional role of hepatocyte growth factor receptor (C-MET) during postnatal rat testis development. Endocrinology 142(5):1828-1834.
77. Catizone A, Ricci G, Arista V, & Galdieri M (2000) Hepatocyte growth factor receptor expression in rat testis. Andrologia 32(1):59-60.
78. Ricci G, Catizone A, Scarcella MF, & Galdieri M (1999) Vitamin A modulation of basement membrane production by purified testicular myoid cells. Experimental cell research 249(1):102-108.
79. Ricci G, Catizone A, Innocenzi A, & Galdieri M (1999) Hepatocyte growth factor (HGF) receptor expression and role of HGF during embryonic mouse testis development. Developmental Biology 216(1):340-347.
80. Catizone A, Ricci G, Arista V, Innocenzi A, & Galdieri M (1999) Hepatocyte growth factor and c-MET are expressed in rat prepuberal testis. Endocrinology 140(7):3106-3113.
81. Catizone A, et al. (1996) Non-specific pinocytosis by human endothelial cells cultured as multicellular aggregates: uptake of lucifer yellow and horse radish peroxidase. Cellular and molecular biology (Noisy-le-Grand, France) 42(8):1229-1242.
82. Catizone A, Medolago Albani L, Reola F, & Alescio T (1993) A quantitative assessment of non specific pinocytosis by human endothelial cells surviving in vitro. Cellular and molecular biology (Noisy-le-Grand, France) 39(2):155-169.
83. Bizzarri M, et al. (1990) Determination of urinary tryptophan and its metabolites along the nicotinic acid pathway by high performance liquid chromatography with ultraviolet detection. Biomedical Chromatography 4(1):24-27.
84. Petrangeli E, et al. (1989) Ploidy, nuclear grade, and steroid receptors as prognostic parameters in human renal cell carcinoma (RCC). Journal of Tumor Marker Oncology 4(3):295-301.
85. Lubrano C, et al. (1989) Epidermal growth factor binding and steroid receptor content in human benign prostatic hyperplasia. Journal of steroid biochemistry 34(1-6):499-504.
86. Concolino G, et al. (1989) Epidermal growth factor (EGF) binding by normal and neoplastic human renal tissue. Journal of Tumor Marker Oncology 4(1):89-97.
87. Franchi F, et al. (1988) In vitro evaluation of drugs active in colorectal carcinoma therapy: A preliminary study in view of the clinical use of chemosensitivity tests. Journal of Experimental and Clinical Cancer Research 7(1):43-48.
88. Concolino G, et al. (1988) PredIctive significance of diploidia and estrogen receptors in human renal carcinoma. Folia Oncologica 11(2):113-117.