ANGELO TOTO

Ricercatore universitario

email: angelo.toto@uniroma1.it
telefono: 065759772

Angelo Toto, PhD

Email: angelo.toto@uniroma1.it

Titoli di studio

2012 - Master’s Degree in Neurobiology LM (DM 270/04) - ORDIN. 2010] (classe LM-6), Facoltà di SCIENZE MATEMATICHE, FISICHE E NATURALI, Sapienza University of Rome

2015 - PhD in Biochemistry, Department of Biochemical Sciences, Sapienza University of Rome. Classification: Excellent.

Carriera accademica

01/11/2012-31/10/2015 - PhD student at Department of Biochemical Sciences, Sapienza University of Rome. Tutor: Prof. Stefano Gianni

01/01/2015-31/03/2015 - Visiting PhD student at Uppsala Universitet - Department of Medical Biochemistry and Microbiology (IMBIM), supervisor Prof. Per Jemth

01/11/2015-31/10/2016 – Postdoc fellow at Department of Biochemical Sciences, Sapienza University of Rome. Supervisor: Prof. Stefano Gianni

01/11/2016-31/10/2017 - Postdoc fellow at AFMB, Universitè d'Aix-Marseille, Marseille, France. Supervisor: Dr. Sonia Longhi

01/11/2017-31/10/2018 - Postdoc fellow at Department of Biochemical Sciences, Sapienza University of Rome

01/11/2018-31/03/2020 - Principal Investigator at Istituto Pasteur Italia - Fondazione Cenci-Bolognetti, Department of Biochemical Sciences, Sapienza University of Rome

01/04/2020-31/05/2022 – Ricercatore a Tempo Determinato Tipologia A, SSD BIO/10, Department of Biochemical Sciences, Sapienza University of Rome

01/06/2022-Present - Ricercatore a Tempo Determinato Tipologia B, SSD BIO/11, Department of Biochemical Sciences, Sapienza University of Rome

Produzione scientifica

11573/1706810 - 2024 - The binding selectivity of the C-terminal SH3 domain of Grb2, but not its folding pathway, is dictated by its contiguous SH2 domain

Di Felice, Mariana; Pagano, Livia; Pennacchietti, Valeria; Diop, Awa; Pietrangeli, Paola; Marcocci, Lucia; Di Matteo, Sara; Malagrinò, Francesca; Toto, Angelo; Gianni, Stefano - 01a Articolo in rivista

rivista: THE JOURNAL OF BIOLOGICAL CHEMISTRY (American Society for Biochemistry and Molecular Biology:9650 Rockville Pike:Bethesda, MD 20814:(301)530-7145, EMAIL: asbmb@asbmb.faseb.org, INTERNET: http://www.faseb.org/asbmb, Fax: (301)571-1824) pp. - - issn: 0021-9258 - wos: (0) - scopus: 2-s2.0-85188713900 (2)

11573/1711132 - 2024 - PDZ2-conjugated-PLGA nanoparticles are tiny heroes in the battle against SARS-CoV-2

Giacon, Noah; Lo Cascio, Ettore; Pennacchietti, Valeria; De Maio, Flavio; Santarelli, Giulia; Sibilia, Diego; Tiberio, Federica; Sanguinetti, Maurizio; Lattanzi, Wanda; Toto, Angelo; Arcovito, Alessandro - 01a Articolo in rivista

rivista: SCIENTIFIC REPORTS (London: Springer Nature London: Nature Publishing Group) pp. - - issn: 2045-2322 - wos: WOS:001244410300034 (5) - scopus: (0)

11573/1703621 - 2024 - Critical assessment of genome interpretation consortium. CAGI, the critical assessment of genome interpretation, establishes progress and pprospects for computational genetic variant interpretation methods.

Jain, Shantanu; Bakolitsa, Constantina; E Brenner, Steven; Radivojac, Predrag; Moult, John; Repo, Susanna; A Hoskins, Roger; Andreoletti, Gaia; Barsky, Daniel; Chellapan, Ajithavalli; Chu, Hoyin; Dabbiru, Navya; K Kollipara, Naveen; Ly, Melissa; J Neumann, Andrew; R Pal, Lipika; Odell, Eric; Pandey, Gaurav; C Peters-Petrulewicz, Robin; Srinivasan, Rajgopal; F Yee, Stephen; Jyothsna Yeleswarapu, Sri; Zuhl, Maya; Adebali, Ogun; Patra, Ayoti; A Beer, Michael; Hosur, Raghavendra; Peng, Jian; M Bernard, Brady; Berry, Michael; Dong, Shengcheng; P Boyle, Alan; Adhikari, Aashish; Chen, Jingqi; Hu, Zhiqiang; Wang, Robert; Wang, Yaqiong; Miller, Maximilian; Wang, Yanran; Bromberg, Yana; Turina, Paola; Capriotti, Emidio; J Han, James; Ozturk, Kivilcim; Carter, Hannah; Babbi, Giulia; Bovo, Samuele; Di Lena, Pietro; Luigi Martelli, Pier; Savojardo, Castrense; Casadio, Rita; S Cline, Melissa; De Baets, Greet; Bonache, Sandra; Díez, Orland; Gutiérrez-Enríquez, Sara; Fernández, Alejandro; Montalban, Gemma; Ootes, Lars; Özkan, Selen; Padilla, Natàlia; Riera, Casandra; De La Cruz, Xavier; Diekhans, Mark; J Huwe, Peter; Wei, Qiong; Xu, Qifang; L Dunbrack, Roland; Gotea, Valer; Elnitski, Laura; Margolin, Gennady; Fariselli, Piero; V Kulakovskiy, Ivan; J Makeev, Vsevolod; D Penzar, Dmitry; E Vorontsov, Ilya; V Favorov, Alexander; R Forman, Julia; Hasenahuer, Marcia; S Fornasari, Maria; Parisi, Gustavo; Avsec, Ziga; H Çelik, Muhammed; Yen Duong Nguyen, Thi; Gagneur, Julien; Shi, Fang-Yuan; D Edwards, Matthew; Guo, Yuchun; Tian, Kevin; Zeng, Haoyang; K Gifford, David; Göke, Jonathan; Zaucha, Jan; Gough, Julian; S Ritchie, Graham R; Frankish, Adam; M Mudge, Jonathan; Harrow, Jennifer; L Young, Erin; Yu, Yao; D Huff, Chad; Murakami, Katsuhiko; Nagai, Yoko; Imanishi, Tadashi; J Mungall, Christopher; B Jacobsen, Julius O; Kim, Dongsup; Jeong, Chan-Seok; T Jones, David; Jun Li, Mulin; Beleva Guthrie, Violeta; Bhattacharya, Rohit; Chen, Yun-Ching; Douville, Christopher; Fan, Jean; Kim, Dewey; Masica, David; Niknafs, Noushin; Sengupta, Sohini; Tokheim, Collin; N Turner, Tychele; Ting Grace Yeo, Hui; Karchin, Rachel; Shin, Sunyoung; Welch, Rene; Keles, Sunduz; Li, Yue; Kellis, Manolis; Corbi-Verge, Carles; V Strokach, Alexey; M Kim, Philip; E Klein, Teri; Mohan, Rahul; A Sinnott-Armstrong, Nicholas; Wainberg, Michael; Kundaje, Anshul; Gonzaludo, Nina; Y Mak, Angel C; Chhibber, Aparna; K Lam, Hugo Y; Dahary, Dvir; Fishilevich, Simon; Lancet, Doron; Lee, Insuk; Bachman, Benjamin; Katsonis, Panagiotis; C Lua, Rhonald; J Wilson, Stephen; Lichtarge, Olivier; R Bhat, Rajendra; Sundaram, Laksshman; Viswanath, Vivek; Bellazzi, Riccardo; Nicora, Giovanna; Rizzo, Ettore; Limongelli, Ivan; M Mezlini, Aziz; Chang, Ray; Kim, Serra; Lai, Carmen; O'connor, Robert; Topper, Scott; Van Den Akker, Jeroen; Y Zhou, Alicia; D Zimmer, Anjali; Mishne, Gilad; R Bergquist, Timothy; R Breese, Marcus; F Guerrero, Rafael; Jiang, Yuxiang; Kiga, Nikki; Li, Biao; Mort, Matthew; A Pagel, Kymberleigh; Pejaver, Vikas; H Stamboulian, Moses; Thusberg, Janita; D Mooney, Sean; Teerakulkittipong, Nuttinee; Cao, Chen; Kundu, Kunal; Yin, Yizhou; Yu, Chen-Hsin; Kleyman, Michael; Lin, Chiao-Feng; Stackpole, Mary; M Mount, Stephen; Eraslan, Gökcen; S Mueller, Nikola; Naito, Tatsuhiko; R Rao, Aliz; R Azaria, Johnathan; Brodie, Aharon; Ofran, Yanay; Garg, Aditi; Pal, Debnath; Hawkins-Hooker, Alex; Kenlay, Henry; Reid, John; J Mucaki, Eliseos; K Rogan, Peter; M Schwarz, Jana; B Searls, David; Rie Lee, Gyu; Seok, Chaok; Krämer, Andreas; Shah, Sohela; V Huang, Chenglai; F Kirsch, Jack; Shatsky, Maxim; Cao, Yue; Chen, Haoran; Karimi, Mostafa; Moronfoye, Oluwaseyi; Sun, Yuanfei; Shen, Yang; Shigeta, Ron; T Ford, Colby; Nodzak, Conor; Uppal, Aneeta; Shi, Xinghua; Joseph, Thomas; Kotte, Sujatha; Rana, Sadhna; Rao, Aditya; G Saipradeep, V; Sivadasan, Naveen; Sunderam, Uma; Stanke, Mario; Su, Andrew; Adzhubey, Ivan; M Jordan, Daniel; Sunyaev, Shamil; Rousseau, Fr - 01a Articolo in rivista

rivista: GENOME BIOLOGY (BioMed Central) pp. 1-46 - issn: 1474-760X - wos: WOS:001184832400002 (7) - scopus: 2-s2.0-85187866396 (11)

11573/1716767 - 2024 - GRB2: A dynamic adaptor protein orchestrating cellular signaling in health and disease

Malagrinò, Francesca; Puglisi, Elena; Pagano, Livia; Travaglini-Allocatelli, Carlo; Toto, Angelo - 01g Articolo di rassegna (Review)

rivista: BIOCHEMISTRY AND BIOPHYSICS REPORTS ([Amsterdam] : Elsevier B.V.) pp. 1-8 - issn: 2405-5808 - wos: WOS:001282612600001 (0) - scopus: 2-s2.0-85199691130 (0)

11573/1702558 - 2024 - Exploring the short linear motif-mediated protein-protein interactions of CrkL through ProP-PD

Pagano, L.; Simonetti, L.; Pennacchietti, V.; Toto, A.; Malagrinò, F.; Ivarsson, Y.; Gianni, S. - 01a Articolo in rivista

rivista: BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (San Diego [etc.]: Elsevier [etc.]) pp. 149658- - issn: 0006-291X - wos: WOS:001197686500001 (0) - scopus: 2-s2.0-85186076885 (0)

11573/1711822 - 2024 - Folding and binding kinetics of the tandem of SH2 domains from SHP2

Pagano, Livia; Pennacchietti, Valeria; Malagrinò, Francesca; Di Felice, Mariana; Toso, Julian; Puglisi, Elena; Gianni, Stefano; Toto, Angelo - 01a Articolo in rivista

rivista: INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (Basel: MDPI Center) pp. - - issn: 1422-0067 - wos: WOS:001255961100001 (0) - scopus: (0)

11573/1726961 - 2024 - A PDZ tandem repeat folds and unfolds via different pathways

Pennacchietti, Valeria; Di Matteo, Sara; Pagano, Livia; Toplek, Fran Bačić; Stegani, Bruno; Toto, Angelo; Toso, Julian; Puglisi, Elena; Capelli, Riccardo; Di Felice, Mariana; Malagrinò, Francesca; Camilloni, Carlo; Gianni, Stefano - 01a Articolo in rivista

rivista: PROTEIN SCIENCE (Cambridge University Press / New York:40 West 20th Street:New York, NY 10011:(800)872-7423, (212)924-3900, EMAIL: journals_subscriptions@cup.org, INTERNET: http://www.journals.cambridge.org, Fax: (212)691-3239) pp. - - issn: 0961-8368 - wos: (0) - scopus: (0)

11573/1707732 - 2024 - The mechanism of folding of human frataxin in comparison to the yeast homologue – broad energy barriers and the general properties of the transition state

Pietrangeli, Paola; Marcocci, Lucia; Pennacchietti, Valeria; Diop, Awa; Di Felice, Mariana; Pagano, Livia; Malagrinò, Francesca; Toto, Angelo; Brunori, Maurizio; Gianni, Stefano - 01a Articolo in rivista

rivista: JOURNAL OF MOLECULAR BIOLOGY (-LONDON, ENGLAND: ACADEMIC PRESS LTD ELSEVIER SCIENCE LTD, -London; New York: Academic Press.) pp. - - issn: 0022-2836 - wos: WOS:001223623100001 (0) - scopus: 2-s2.0-85189293931 (0)

11573/1680491 - 2023 - Targeting the Grb2 cSH3 domain: design, synthesis and biological evaluation of the first series of modulators

Bufano, Marianna; Puxeddu, Michela; Nalli, Marianna; La Regina, Giuseppe; Toto, Angelo; Liberati, Francesca Romana; Paone, Alessio; Cutruzzolà, Francesca; Masci, Domiziana; Bigogno, Chiara; Dondio, Giulio; Silvestri, Romano; Gianni, Stefano; Coluccia, Antonio - 01a Articolo in rivista

rivista: BIOORGANIC CHEMISTRY (Academic Press Incorporated:6277 Sea Harbor Drive:Orlando, FL 32887:(800)543-9534, (407)345-4100, EMAIL: ap@acad.com, INTERNET: http://www.idealibrary.com, Fax: (407)352-3445) pp. 106607- - issn: 0045-2068 - wos: WOS:001007153500001 (2) - scopus: 2-s2.0-85159597372 (2)

11573/1683686 - 2023 - Biophysical characterization of the binding mechanism between the MATH domain of SPOP and its physiological partners

Diop, Awa; Pietrangeli, Paola; Nardella, Caterina; Pennacchietti, Valeria; Pagano, Livia; Toto, Angelo; Di Felice, Mariana; Di Matteo, Sara; Marcocci, Lucia; Malagrinò, Francesca; Gianni, Stefano - 01a Articolo in rivista

rivista: INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (Basel: MDPI Center) pp. 10138- - issn: 1422-0067 - wos: WOS:001017317000001 (2) - scopus: 2-s2.0-85163977385 (2)

11573/1695759 - 2023 - Addressing the binding mechanism of the Meprin and TRAF-C hmology domain of the Speckle-Type POZ protein using protein engineering

Diop, Awa; Pietrangeli, Paola; Pennacchietti, Valeria; Pagano, Livia; Toto, Angelo; Di Felice, Mariana; Di Matteo, Sara; Marcocci, Lucia; Malagrinò, Francesca; Gianni, Stefano - 01a Articolo in rivista

rivista: INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (Basel: MDPI Center) pp. - - issn: 1422-0067 - wos: WOS:001131010700001 (0) - scopus: 2-s2.0-85180652606 (1)

11573/1682765 - 2023 - Monomeric and dimeric states of human ZO1-PDZ2 are functional partners of the SARS-CoV-2 E protein

Giacon, Noah; Lo Cascio, Ettore; Davidson, Darcy S.; Polêto, Marcelo D.; Lemkul, Justin A.; Pennacchietti, Valeria; Pagano, Livia; Zamparelli, Carlotta; Toto, Angelo; Arcovito, Alessandro - 01a Articolo in rivista

rivista: COMPUTATIONAL AND STRUCTURAL BIOTECHNOLOGY JOURNAL (Göteborg : Chalmers University of Technology, 2011-) pp. 3259-3271 - issn: 2001-0370 - wos: WOS:001020735300001 (1) - scopus: 2-s2.0-85161275182 (1)

11573/1685968 - 2023 - An intramolecular energetic network regulates ligand recognition in a SH2 domain

Nardella, Caterina; Pagano, Livia; Pennacchietti, Valeria; Felice, Mariana Di; Matteo, Sara Di; Diop, Awa; Malagrinò, Francesca; Marcocci, Lucia; Pietrangeli, Paola; Gianni, Stefano; Toto, Angelo - 01a Articolo in rivista

11573/1686025 - 2023 - Characterization of the folding and binding properties of the PTB domain of FRS2 with phosphorylated and unphosphorylated ligands

Pennacchietti, Valeria; Pagano, Livia; Malagrinò, Francesca; Diop, Awa; Di Felice, Mariana; Di Matteo, Sara; Marcocci, Lucia; Pietrangeli, Paola; Toto, Angelo; Gianni, Stefano - 01a Articolo in rivista

rivista: ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS (Attuale:ELSEVIER SCIENCE INC, 360 PARK AVE SOUTH, NEW YORK, USA, NY, 10010-1710 Academic Press Incorporated:6277 Sea Harbor Drive:Orlando, FL 32887:(800)543-9534, (407)345-4100, EMAIL: ap@acad.com, INTERNET: http://www.idealibrary.com, Fax: (407)352-3445) pp. 109703- - issn: 0003-9861 - wos: WOS:001053305400001 (0) - scopus: 2-s2.0-85166633882 (0)

11573/1679810 - 2023 - Different electrostatic forces drive the binding kinetics of SARS-CoV, SARS-CoV-2 and MERS-CoV Envelope proteins with the PDZ2 domain of ZO1

Pennacchietti, Valeria; Toto, Angelo - 01a Articolo in rivista

rivista: SCIENTIFIC REPORTS (London: Springer Nature London: Nature Publishing Group) pp. - - issn: 2045-2322 - wos: WOS:000992335400005 (2) - scopus: 2-s2.0-85159461892 (2)

11573/1673852 - 2023 - Understanding the molecular basis of folding cooperativity through a comparative analysis of a multidomain protein and its isolated domains

Santorelli, Daniele; Marcocci, Lucia; Pennacchietti, Valeria; Nardella, Caterina; Diop, Awa; Pietrangeli, Paola; Pagano, Livia; Toto, Angelo; Malagrino, Francesca; Gianni, Stefano - 01a Articolo in rivista

rivista: THE JOURNAL OF BIOLOGICAL CHEMISTRY (American Society for Biochemistry and Molecular Biology:9650 Rockville Pike:Bethesda, MD 20814:(301)530-7145, EMAIL: asbmb@asbmb.faseb.org, INTERNET: http://www.faseb.org/asbmb, Fax: (301)571-1824) pp. 102983- - issn: 0021-9258 - wos: WOS:001009100600001 (3) - scopus: 2-s2.0-85149793931 (3)

11573/1616528 - 2022 - Anticancer activity of (S)-5-Chloro-3-((3,5-dimethylphenyl)sulfonyl)-N-(1-oxo-1-((pyridin-4-ylmethyl)amino)propan-2-yl)-1H-indole-2-carboxamide (RS4690), a new dishevelled 1 inhibitor

Coluccia, Antonio; Bufano, Marianna; La Regina, Giuseppe La; Puxeddu, Michela; Toto, Angelo; Paone, Alessio; Bouzidi, Amani; Musto, Giorgia; Badolati, Nadia; Orlando, Viviana; Biagioni, Stefano; Masci, Domiziana; Cantatore, Chiara; Cirilli, Roberto; Cutruzzolà, Francesca; Gianni, Stefano; Stornaiuolo, Mariano; Silvestri, Romano - 01a Articolo in rivista

rivista: CANCERS (Basel: MDPI) pp. - - issn: 2072-6694 - wos: WOS:000773498900001 (5) - scopus: 2-s2.0-85131007159 (6)

11573/1662469 - 2022 - SH2 Domains: folding, binding and therapeutical approaches

Diop, Awa; Santorelli, Daniele; Malagrinò, Francesca; Nardella, Caterina; Pennacchietti, Valeria; Pagano, Livia; Marcocci, Lucia; Pietrangeli, Paola; Gianni, Stefano; Toto, Angelo - 01a Articolo in rivista

rivista: INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (Basel: MDPI Center) pp. 15944- - issn: 1422-0067 - wos: WOS:000902565100001 (18) - scopus: 2-s2.0-85144969444 (21)

11573/1659078 - 2022 - The cooperative folding of annexin A2 relies on a transient nonnative intermediate

Hollås, Hanne; Ramirez, Juan; Nominé, Yves; Kostmann, Camille; Toto, Angelo; Gianni, Stefano; Travé, Gilles; Vedeler, Anni - 01a Articolo in rivista

rivista: BIOPHYSICAL JOURNAL (New York: Published for the Biophysical Society by the Rockefeller University Press) pp. - - issn: 0006-3495 - wos: WOS:000908349700009 (1) - scopus: 2-s2.0-85141976426 (1)

11573/1607647 - 2022 - On the effects of disordered tails, supertertiary structure and quinary interactions on the folding and function of protein domains

Malagrino, F.; Pennacchietti, V.; Santorelli, D.; Pagano, L.; Nardella, C.; Diop, A.; Toto, A.; Gianni, S. - 01a Articolo in rivista

rivista: BIOMOLECULES (Basel: MDPI) pp. 209- - issn: 2218-273X - wos: WOS:000763931100001 (7) - scopus: 2-s2.0-85123285981 (7)

11573/1652072 - 2022 - Cryptic binding properties of a transient folding intermediate in a PDZ tandem repeat

Malagrinò, Francesca; Fusco, Giuliana; Pennacchietti, Valeria; Toto, Angelo; Nardella, Caterina; Pagano, Livia; De Simone, Alfonso; Gianni, Stefano - 01a Articolo in rivista

11573/1651291 - 2022 - Folding and binding mechanisms of the SH2 domain from Crkl

Nardella, Caterina; Toto, Angelo; Santorelli, Daniele; Pagano, Livia; Diop, Awa; Pennacchietti, Valeria; Pietrangeli, Paola; Marcocci, Lucia; Malagrinò, Francesca; Gianni, Stefano - 01a Articolo in rivista

rivista: BIOMOLECULES (Basel: MDPI) pp. 1014- - issn: 2218-273X - wos: WOS:000846180000001 (4) - scopus: 2-s2.0-85137360513 (5)

11573/1657644 - 2022 - Exploring the effect of tethered domains on the folding of Grb2 protein

Pagano, Livia; Pennacchietti, Valeria; Diop, Awa; Santorelli, Daniele; Pietrangeli, Paola; Marcocci, Lucia; Nardella, Caterina; Malagrinò, Francesca; Toto, Angelo; Gianni, Stefano - 01a Articolo in rivista

rivista: ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS (Attuale:ELSEVIER SCIENCE INC, 360 PARK AVE SOUTH, NEW YORK, USA, NY, 10010-1710 Academic Press Incorporated:6277 Sea Harbor Drive:Orlando, FL 32887:(800)543-9534, (407)345-4100, EMAIL: ap@acad.com, INTERNET: http://www.idealibrary.com, Fax: (407)352-3445) pp. 109444- - issn: 0003-9861 - wos: WOS:000880049100004 (3) - scopus: 2-s2.0-85141826263 (4)

11573/1635685 - 2022 - Characterization of early and late transition states of the folding pathway of a SH2 domain

Toto, Angelo; Malagrinò, Francesca; Nardella, Caterina; Pennacchietti, Valeria; Pagano, Livia; Santorelli, Daniele; Diop, Awa; Gianni, Stefano - 01a Articolo in rivista

11573/1536463 - 2021 - Structural determinants driving the binding process between PDZ domain of wild type human PALS1 protein and SLiM sequences of SARS-CoV E proteins

Lo Cascio, E.; Toto, A.; Babini, G.; De Maio, F.; Sanguinetti, M.; Mordente, A.; Della Longa, S.; Arcovito, A. - 01a Articolo in rivista

rivista: COMPUTATIONAL AND STRUCTURAL BIOTECHNOLOGY JOURNAL (Göteborg : Chalmers University of Technology, 2011-) pp. 1838-1847 - issn: 2001-0370 - wos: WOS:000684934900009 (11) - scopus: 2-s2.0-85103692581 (12)

11573/1593241 - 2021 - Unveiling induced folding of intrinsically disordered proteins - Protein engineering, frustration and emerging themes

Malagrinò, Francesca; Diop, Awa; Pagano, Livia; Nardella, Caterina; Toto, Angelo; Gianni, Stefano - 01a Articolo in rivista

rivista: CURRENT OPINION IN STRUCTURAL BIOLOGY (Current Biology Limited:84 Theobalds Road, London WC1X 8RR United Kingdom:011 44 20 76114202, EMAIL: info@biomednet.com, INTERNET: http://www.biomednet.com, Fax: 011 44 20 76114479) pp. 160-160 - issn: 0959-440X - wos: WOS:000768730600018 (13) - scopus: 2-s2.0-85120903843 (17)

11573/1577022 - 2021 - Determining folding and binding properties of the C-terminal SH2 domain of SHP2

Nardella, Caterina; Malagrinò, Francesca; Pagano, Livia; Rinaldo, Serena; Gianni, Stefano; Toto, Angelo - 01a Articolo in rivista

11573/1579282 - 2021 - Targeting PDZ domains as potential treatment for viral infections, neurodegeneration and cancer

Nardella, Caterina; Visconti, Lorenzo; Malagrinò, Francesca; Pagano, Livia; Bufano, Marianna; Nalli, Marianna; Coluccia, Antonio; La Regina, Giuseppe; Silvestri, Romano; Gianni, Stefano; Toto, Angelo - 01a Articolo in rivista

rivista: BIOLOGY DIRECT (London: BioMed Central) pp. - - issn: 1745-6150 - wos: WOS:000706722300001 (12) - scopus: 2-s2.0-85117321017 (14)

11573/1596175 - 2021 - Experimental characterization of the interaction between the n-terminal sh3 domain of crkl and c3g

Pagano, L.; Malagrino, F.; Nardella, C.; Gianni, S.; Toto, A. - 01a Articolo in rivista

rivista: INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (Basel (Matthaeustrasse 11) : Molecular Diversity Preservation International MDPI) pp. 13174- - issn: 1661-6596 - wos: WOS:000738238000001 (1) - scopus: 2-s2.0-85120657305 (1)

11573/1552783 - 2021 - Probing the effects of local frustration in the folding of a multidomain protein

Pagano, Livia; Malagrinò, Francesca; Visconti, Lorenzo; Troilo, Francesca; Pennacchietti, Valeria; Nardella, Caterina; Toto, Angelo; Gianni, Stefano - 01a Articolo in rivista

rivista: JOURNAL OF MOLECULAR BIOLOGY (-LONDON, ENGLAND: ACADEMIC PRESS LTD ELSEVIER SCIENCE LTD, -London; New York: Academic Press.) pp. 167087- - issn: 0022-2836 - wos: WOS:000672680300017 (6) - scopus: 2-s2.0-85107967375 (6)

11573/1477086 - 2021 - Double mutant cycles as a tool to address folding, binding, and allostery

Pagano, Livia; Toto, Angelo; Malagrinò, Francesca; Visconti, Lorenzo; Jemth, Per; Gianni, Stefano - 01a Articolo in rivista

rivista: INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (Basel: MDPI Center) pp. 828- - issn: 1422-0067 - wos: WOS:000611298300001 (9) - scopus: 2-s2.0-85099547793 (11)

11573/1495668 - 2021 - Folding and misfolding of a PDZ tandem repeat

Visconti, Lorenzo; Malagrinò, Francesca; Troilo, Francesca; Pagano, Livia; Toto, Angelo; Gianni, Stefano - 01a Articolo in rivista

rivista: JOURNAL OF MOLECULAR BIOLOGY (-LONDON, ENGLAND: ACADEMIC PRESS LTD ELSEVIER SCIENCE LTD, -London; New York: Academic Press.) pp. 166862- - issn: 0022-2836 - wos: WOS:000630007900009 (7) - scopus: 2-s2.0-85100673226 (9)

11573/1435307 - 2020 - Hidden kinetic traps in multidomain folding highlight the presence of a misfolded but functionally competent intermediate

Gautier, Candice; Troilo, Francesca; Cordier, Florence; Malagrinò, Francesca; Toto, Angelo; Visconti, Lorenzo; Zhu, Yanlei; Brunori, Maurizio; Wolff, Nicolas; Gianni, Stefano - 01a Articolo in rivista

rivista: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (National Academy of Sciences:2101 Constitution Avenue Northwest:Washington, DC 20418:(877)314-2253, (615)377-3322, EMAIL: subspnas@nas.edu, INTERNET: http://www.pnas.org, Fax: (615)377-0525) pp. 19963-19969-19969 - issn: 0027-8424 - wos: WOS:000567818600007 (14) - scopus: 2-s2.0-85089787733 (16)

11573/1456152 - 2020 - Targeting the interaction between the SH3 domain of Grb2 and Gab2

Malagrinò, Francesca; Coluccia, Antonio; Bufano, Marianna; La Regina, Giuseppe; Puxeddu, Michela; Toto, Angelo; Visconti, Lorenzo; Paone, Alessio; Magnifico, Maria Chiara; Troilo, Francesca; Cutruzzolà, Francesca; Silvestri, Romano; Gianni, Stefano - 01a Articolo in rivista

rivista: CELLS (Basel: mdpi-Molecular Diversity Preservation International) pp. 2435- - issn: 2073-4409 - wos: WOS:000592940700001 (7) - scopus: 2-s2.0-85096028884 (7)

11573/1401198 - 2020 - Understanding the binding induced folding of intrinsically disordered proteins by protein engineering: caveats and pitfalls

Malagrinò, Francesca; Visconti, Lorenzo; Pagano, Livia; Toto, Angelo; Troilo, Francesca; Gianni, Stefano - 01a Articolo in rivista

rivista: INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (Basel: MDPI Center) pp. 3484- - issn: 1422-0067 - wos: WOS:000539312100080 (12) - scopus: 2-s2.0-85084964055 (14)

11573/1359552 - 2020 - Unveiling the molecular basis of the noonan syndrome-causing mutation T42A of SHP2

Toto, A.; Malagrino, F.; Visconti, L.; Troilo, F.; Gianni, S. - 01a Articolo in rivista

rivista: INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (Basel (Matthaeustrasse 11) : Molecular Diversity Preservation International MDPI) pp. 461- - issn: 1661-6596 - wos: WOS:000515380000091 (6) - scopus: 2-s2.0-85077880233 (9)

11573/1445451 - 2020 - Understanding binding-induced folding by temperature jump

Toto, A.; Troilo, F.; Malagrino, F.; Gianni, S. - 02a Capitolo o Articolo

libro: Methods in Molecular Biology - (978-1-0716-0523-3; 978-1-0716-0524-0)

11573/1435303 - 2020 - Comparing the binding properties of peptides mimicking the envelope protein of sars-cov and sars-cov-2 to the pdz domain of the tight junction-associated pals1 protein

Toto, Angelo; Ma, Sana; Malagrinò, Francesca; Visconti, Lorenzo; Pagano, Livia; Stromgaard, Kristian; Gianni, Stefano - 01a Articolo in rivista

11573/1401188 - 2020 - Templated folding of intrinsically disordered proteins

Toto, Angelo; Malagrinò, Francesca; Visconti, Lorenzo; Troilo, Francesca; Pagano, Livia; Brunori, Maurizio; Jemth, Per; Gianni, Stefano - 01a Articolo in rivista

rivista: THE JOURNAL OF BIOLOGICAL CHEMISTRY (American Society for Biochemistry and Molecular Biology:9650 Rockville Pike:Bethesda, MD 20814:(301)530-7145, EMAIL: asbmb@asbmb.faseb.org, INTERNET: http://www.faseb.org/asbmb, Fax: (301)571-1824) pp. 6586-6593 - issn: 0021-9258 - wos: WOS:000537685000027 (48) - scopus: 2-s2.0-85084721842 (47)

11573/1359561 - 2020 - The effect of proline cis‐trans isomerization on the folding of the C‐terminal SH2 domain from p85

Troilo, F.; Malagrino, F.; Visconti, L.; Toto, A.; Gianni, S. - 01a Articolo in rivista

rivista: INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (Basel (Matthaeustrasse 11) : Molecular Diversity Preservation International MDPI) pp. 125- - issn: 1661-6596 - wos: WOS:000515378000125 (4) - scopus: 2-s2.0-85077263439 (5)

11573/1417653 - 2020 - Understanding the mechanism of recognition of gab2 by the n-sh2 domain of shp2

Visconti, Lorenzo; Malagrinò, Francesca; Pagano, Livia; Toto, Angelo - 01a Articolo in rivista

rivista: LIFE (Basel: MDPI) pp. 85- - issn: 2075-1729 - wos: WOS:000551223300004 (8) - scopus: 2-s2.0-85090739226 (9)

11573/1399303 - 2020 - Demonstration of binding induced structural plasticity in a sh2 domain

Visconti, Lorenzo; Toto, Angelo; Jarvis, James A.; Troilo, Francesca; Malagrinò, Francesca; De Simone, Alfonso; Gianni, Stefano - 01a Articolo in rivista

rivista: FRONTIERS IN MOLECULAR BIOSCIENCES (Lausanne : Frontiers Media S.A., 2014-) pp. - - issn: 2296-889X - wos: WOS:000537268200001 (6) - scopus: (0)

11573/1336078 - 2019 - Mapping the allosteric network within a SH3 domain

Malagrinò, F.; Troilo, F.; Bonetti, D.; Toto, A.; Gianni, S. - 01a Articolo in rivista

rivista: SCIENTIFIC REPORTS (London: Springer Nature London: Nature Publishing Group) pp. - - issn: 2045-2322 - wos: WOS:000470075600028 (16) - scopus: 2-s2.0-85066618062 (18)

11573/1277788 - 2019 - Characterization of human frataxin missense variants in cancer tissues

Petrosino, Maria; Pasquo, Alessandra; Novak, Leonore; Toto, Angelo; Gianni, Stefano; Mantuano, Elide; Veneziano, Liana; Minicozzi, Velia; Pastore, Annalisa; Puglisi, Rita; Capriotti, Emidio; Chiaraluce, Roberta; Consalvi, Valerio - 01a Articolo in rivista

rivista: HUMAN MUTATION (John Wiley & Sons Incorporated:Customer Service, 111 River Street:Hoboken, NJ 07030:(800)225-5945, (201)748-6000, EMAIL: societyinfo@wiley.com, INTERNET: http://www.wiley.com, Fax: (212)748-6551) pp. 1-14 - issn: 1059-7794 - wos: WOS:000485994200020 (14) - scopus: 2-s2.0-85070717849 (16)

11573/1336088 - 2019 - Binding induced folding: Lessons from the kinetics of interaction between NTAIL and XD

Toto, A.; Troilo, F.; Visconti, L.; Malagrinò, F.; Bignon, C.; Longhi, Sonia Rachele Agata; Gianni, S.; S, - 01a Articolo in rivista

rivista: ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS (Attuale:ELSEVIER SCIENCE INC, 360 PARK AVE SOUTH, NEW YORK, USA, NY, 10010-1710 Academic Press Incorporated:6277 Sea Harbor Drive:Orlando, FL 32887:(800)543-9534, (407)345-4100, EMAIL: ap@acad.com, INTERNET: http://www.idealibrary.com, Fax: (407)352-3445) pp. 255-261 - issn: 0003-9861 - wos: WOS:000525438900029 (6) - scopus: 2-s2.0-85069557296 (7)

11573/1336085 - 2019 - Structural characterization of an on-pathway intermediate and transition state in the folding of the N-terminal SH2 domain from SHP2

Visconti, L.; Malagrinò, F.; Gianni, S.; Toto, A. - 01a Articolo in rivista

rivista: THE FEBS JOURNAL (Blackwell Pub., Oxford, UK) pp. 4769-4777 - issn: 1742-4658 - wos: WOS:000499718600012 (7) - scopus: 2-s2.0-85069838702 (8)

11573/1218458 - 2019 - Investigating the molecular basis of the aggregation propensity of the pathological d76n mutant of beta-2 microglobulin: role of the denatured state

Visconti, L; Malagrinò, F; Broggini, L; De Luca, Cmg; Moda, F; Gianni, S; Ricagno, S; Toto, A. - 01a Articolo in rivista

rivista: INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (Basel (Matthaeustrasse 11) : Molecular Diversity Preservation International MDPI) pp. - - issn: 1661-6596 - wos: WOS:000459746500164 (5) - scopus: 2-s2.0-85060402058 (5)

11573/1253355 - 2019 - The kinetics of folding of the NSH2 domain from p85

Visconti, Lorenzo; Malagrinò, Francesca; Toto, Angelo; Gianni, Stefano - 01a Articolo in rivista

rivista: SCIENTIFIC REPORTS (London: Springer Nature London: Nature Publishing Group) pp. 4058- - issn: 2045-2322 - wos: WOS:000460751700013 (9) - scopus: 2-s2.0-85062766339 (9)

11573/1140852 - 2018 - Mechanism of folding and binding of the n-terminal SH2 domain from SHP2

Bonetti, Daniela; Troilo, Francesca; Toto, Angelo; Travaglini-Allocatelli, Carlo; Brunori, Maurizio; Gianni, Stefano - 01a Articolo in rivista

rivista: JOURNAL OF PHYSICAL CHEMISTRY. B, CONDENSED MATTER, MATERIALS, SURFACES, INTERFACES & BIOPHYSICAL (American Chemical Society, Washington, D.C.) pp. - - issn: 1520-6106 - wos: WOS:000453488100016 (18) - scopus: 2-s2.0-85050853721 (19)

11573/1159784 - 2018 - Stability of an aggregation-prone partially folded state of human profilin-1 correlates with aggregation propensity

Edoardo Del Poggetto‡, ; Toto, Angelo; Chiara, Aloise‡; Francesco Di Piro‡, ; Ludovica, Gori‡; Malatesta, Francesco; Gianni, Stefano; X Fabrizio Chiti‡, ; And, X Francesco Bemporad‡1 - 01a Articolo in rivista

rivista: JOURNAL OF BIOLOGICAL CHEMISTRY (Bethesda, Md. : American Society for Biochemistry and Molecular Biology) pp. 10303-10313 - issn: 1083-351X - wos: WOS:000437096700028 (9) - scopus: 2-s2.0-85049653406 (9)

11573/1111524 - 2018 - Folding mechanisms steer the amyloid fibril formation propensity of highly homologous proteins

Malgieri, G; D'abrosca, G; Pirone, L; Toto, A; Palmieri, M; Russo, L; Sciacca, Mfm; Tatè, R; Sivo, V; Baglivo, I; Majewska, R; Coletta, M; Pedone, Pv; Isernia, C; De Stefano, M; Gianni, S; Pedone, Em; Milardi, D; Fattorusso, R. - 01a Articolo in rivista

rivista: CHEMICAL SCIENCE (Cambridge : Royal Society of Chemistry, 2010-) pp. 3290-3298 - issn: 2041-6520 - wos: WOS:000431113300004 (17) - scopus: 2-s2.0-85044759336 (18)

11573/1140869 - 2018 - The folding mechanism of the SH3 domain from Grb2

Troilo, Francesca; Bonetti, Daniela; Camilloni, Carlo; Toto, Angelo; Longhi, Sonia; Brunori, Maurizio; Gianni, Stefano - 01a Articolo in rivista

11573/1014998 - 2017 - Analyzing the folding and binding steps of an intrinsically disordered protein by protein engineering

Bonetti, Daniela; Troilo, Francesca; Toto, Angelo; Brunori, Maurizio; Longhi, Sonia; Gianni, Stefano - 01a Articolo in rivista

rivista: BIOCHEMISTRY (American Chemical Society:1155 Sixteenth Street Northwest:Washington, DC 20036:(800)227-5558, EMAIL: service@acs.org, INTERNET: http://www.pubs.acs.org, Fax: (614)447-3671) pp. 3780-3786 - issn: 0006-2960 - wos: WOS:000406573100011 (25) - scopus: 2-s2.0-85025827155 (25)

11573/1014994 - 2017 - Regulation of the human phosphatase ptpn4 by the inter-domain linker connecting the pdz and the phosphatase domains

Caillet-Saguy, Célia; Toto, Angelo; Guerois, Raphael; Maisonneuve, Pierre; Di Silvio, Eva; Sawyer, Kristi; Gianni, Stefano; Wolff, Nicolas - 01a Articolo in rivista

rivista: SCIENTIFIC REPORTS (London: Springer Nature London: Nature Publishing Group) pp. - - issn: 2045-2322 - wos: WOS:000407442500015 (10) - scopus: 2-s2.0-85031675178 (10)

11573/1014977 - 2017 - Understanding the mechanism of binding between Gab2 and the C terminal SH3 domain from Grb2

Toto, Angelo; Bonetti, Daniela; De Simone, Alfonso; Gianni, Stefano - 01a Articolo in rivista

rivista: ONCOTARGET (Albany, N.Y. : Impact Journals) pp. 82344-82351 - issn: 1949-2553 - wos: WOS:000412683900060 (11) - scopus: 2-s2.0-85030863721 (10)

11573/954031 - 2017 - Understanding the role of phosphorylation in the binding mechanism of a PDZ domain

Toto, Angelo; Mattei, A.; Jemth, P.; Gianni, Stefano - 01a Articolo in rivista

rivista: PROTEIN ENGINEERING, DESIGN & SELECTION (Oxford : Oxford University Press) pp. 1-5 - issn: 1741-0134 - wos: WOS:000397129400001 (9) - scopus: 2-s2.0-85014750887 (11)

11573/956496 - 2017 - The folding pathway of the KIX domain

Troilo, Francesca; Bonetti, Daniela; Toto, Angelo; Visconti, L; Brunori, Maurizio; Longhi, S; Gianni, Stefano - 01a Articolo in rivista

rivista: ACS CHEMICAL BIOLOGY (Washington, D.C. : American Chemical Society, c2006-) pp. 1683-1690 - issn: 1554-8937 - wos: WOS:000403854000030 (6) - scopus: 2-s2.0-85020525210 (6)

11573/953785 - 2016 - Activation barrier-limited folding and conformational sampling of a dynamic protein domain

Jakob Dogan, *; Toto, Angelo; Eva Andersson, §; Gianni, Stefano; Per Jemth, § - 01a Articolo in rivista

rivista: BIOCHEMISTRY (American Chemical Society:1155 Sixteenth Street Northwest:Washington, DC 20036:(800)227-5558, EMAIL: service@acs.org, INTERNET: http://www.pubs.acs.org, Fax: (614)447-3671) pp. 5289-5295 - issn: 0006-2960 - wos: WOS:000384038700010 (13) - scopus: 2-s2.0-84988672614 (13)

11573/860590 - 2016 - Molecular recognition by templated folding of an intrinsically disordered protein

Toto, Angelo; Camilloni, Carlo; Giri, Rajanish; Brunori, Maurizio; Vendruscolo, Michele; Gianni, Stefano - 01a Articolo in rivista

rivista: SCIENTIFIC REPORTS (London: Springer Nature London: Nature Publishing Group) pp. 21994- - issn: 2045-2322 - wos: WOS:000370796200001 (81) - scopus: 2-s2.0-84959441550 (83)

11573/931704 - 2016 - Mutational analysis of the binding-induced folding reaction of the mixed-lineage leukemia protein to the KIX domain.

Toto, Angelo; Gianni, Stefano - 01a Articolo in rivista

rivista: BIOCHEMISTRY (American Chemical Society:1155 Sixteenth Street Northwest:Washington, DC 20036:(800)227-5558, EMAIL: service@acs.org, INTERNET: http://www.pubs.acs.org, Fax: (614)447-3671) pp. 3957-3962 - issn: 0006-2960 - wos: WOS:000380297100011 (18) - scopus: 2-s2.0-84979527196 (17)

11573/931691 - 2016 - Ligand binding to the pdz domains of postsynaptic density protein 95

Toto, Angelo; Pedersen, Sw; Karlsson, Oa; Moran, Ge; Andersson, E; Chi, Cn; Strømgaard, K; Gianni, Stefano; Jemth, P. - 01a Articolo in rivista

rivista: PROTEIN ENGINEERING, DESIGN & SELECTION (Oxford : Oxford University Press) pp. 169-175 - issn: 1741-0134 - wos: WOS:000376351600002 (11) - scopus: 2-s2.0-84965026277 (11)

11573/782784 - 2015 - Understanding the effect of alternative splicing in the folding and function of the second pdz from protein tyrosine phosphatase-bl

Di Silvio, E; Toto, Angelo; Bonetti, Daniela; Morrone, A; Gianni, Stefano - 01a Articolo in rivista

rivista: SCIENTIFIC REPORTS (London: Springer Nature London: Nature Publishing Group) pp. 9299- - issn: 2045-2322 - wos: WOS:000351277000008 (3) - scopus: 2-s2.0-84925396547 (3)

11573/554302 - 2014 - The kinetics of folding of frataxin.

Bonetti, Daniela; Toto, Angelo; Giri, R; Morrone, A; Sanfelice, D; Pastore, A; Temussi, P; Gianni, Stefano; Brunori, Maurizio - 01a Articolo in rivista

rivista: PHYSICAL CHEMISTRY CHEMICAL PHYSICS ([London, England] : Royal Society of Chemistry, 1999-) pp. 6391-6397 - issn: 1463-9084 - wos: WOS:000333119800009 (15) - scopus: 2-s2.0-84896367793 (17)

11573/577793 - 2014 - The mechanism of binding of the second PDZ domain from the Protein Tyrosine Phosphatase-BL to the Adenomatous Polyposis Coli tumor suppressor

Di Silvio, Eva; Bonetti, Daniela; Toto, Angelo; A., Morrone; Gianni, Stefano - 01a Articolo in rivista

rivista: PROTEIN ENGINEERING, DESIGN & SELECTION (Oxford University Press) pp. 249-253 - issn: 1741-0126 - wos: WOS:000343042400001 (3) - scopus: 2-s2.0-84906230429 (3)

11573/675273 - 2014 - Understanding the frustration arising from the competition between function, misfolding, and aggregation in a globular protein.

Gianni, Stefano; Camilloni, C; Giri, R; Toto, Angelo; Bonetti, Daniela; Morrone, A; Sormanni, P; Brunori, Maurizio; Vendruscolo, M. - 01a Articolo in rivista

rivista: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (National Academy of Sciences:2101 Constitution Avenue Northwest:Washington, DC 20418:(877)314-2253, (615)377-3322, EMAIL: subspnas@nas.edu, INTERNET: http://www.pnas.org, Fax: (615)377-0525) pp. - - issn: 0027-8424 - wos: WOS:000342350200039 (45) - scopus: 2-s2.0-84907573466 (45)

11573/658425 - 2014 - The mechanism of binding of the KIX domain to the mixed lineage leukemia protein and its allosteric role in the recognition of c-Myb.

Toto, Angelo; Giri, R; Brunori, Maurizio; Gianni, Stefano - 01a Articolo in rivista

11573/554296 - 2013 - Structure of the transition state for the binding of c-Myb and KIX highlights an unexpected order for a disordered system.

Giri, R; Morrone, A; Toto, Angelo; Brunori, Maurizio; Gianni, Stefano - 01a Articolo in rivista

rivista: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (National Academy of Sciences:2101 Constitution Avenue Northwest:Washington, DC 20418:(877)314-2253, (615)377-3322, EMAIL: subspnas@nas.edu, INTERNET: http://www.pnas.org, Fax: (615)377-0525) pp. 14942-14947 - issn: 0027-8424 - wos: WOS:000324125100038 (88) - scopus: 2-s2.0-84883780190 (91)