ANGELICA SCUDERI

Dottoressa di ricerca

ciclo: XXXVII


supervisore: Prof.ssa Mariella Pazzaglia

Titolo della tesi: Body and action in patients with central nervous system injuries

The central nervous system supports a wide range of sensory, motor, and cognitive abilities that are inextricably linked to our body - a body that we inhabit, perceive and control and that allows us to interact with the world around us, primarily through movement. Spinal cord injury or brain damage can severely impair our ability to act, the 'glue' that binds body and mind, profoundly affecting our bodily self and sensorimotor interactions. Through four different experimental studies, this thesis aims to deepen our understanding of the mechanisms underlying body representation, motor control and action perception, particularly in relation to emotional content. The first study examines the role of interoceptive and exteroceptive signals in maintaining body awareness following thoracic spinal cord injury using the rubber hand illusion paradigm and a heartbeat monitoring task. Results reveal that individuals with high thoracic injuries exhibit greater malleability of body ownership, reduced accuracy in perceiving interoceptive signals, and a greater sense of detachment from their body compared to those with lower injuries. The second and third studies focus on apraxia. A systematic review of lesion studies in stroke patients reveals that insular damage is associated with deficits in imitation and pantomime. This finding can be explained by the role of the insula in integrating sensorimotor information, which is crucial for body representation and motor awareness processes. The third study investigates the influence of emotions expressed by specific body parts on action recognition in patients with apraxia. Results indicate that emotional content improves the detection of actions performed with the face and body in patients with bucco-facial and limb apraxia, respectively. Furthermore, voxel-based lesion symptom mapping reveals that emotional processing can occur independently of motor perception within the frontal areas of the action observation network. Finally, the fourth study assesses pupil dilation as a physiological response to the observation and imitation of gestures based on their meaning and spatial direction (towards or away from the body) in a healthy population. Results indicate that observing meaningful gestures modulates autonomic activation, with increased sympathetic activity for gestures associated with mental states or self-care. Individual differences in empathy and prosocial tendencies further influence physiological responses. Interestingly, the imitation condition did not produce significant differences compared to passive observation. These findings provide new insights into the neurocognitive mechanisms underlying body awareness and motor cognition, with potential implications for developing targeted therapeutic strategies following central nervous system injury. Specifically, the results underscore the importance of interoceptive and visual information for maintaining a stable body representation after spinal cord injury. They also highlight that insular damage is associated with symptoms of apraxia and not as a mere consequence of middle cerebral artery infarction. The last two studies demonstrate the complex interaction between actions and their communicative (symbolic or emotional) value in gesture processing.

Produzione scientifica

11573/1726090 - 2024 - Rhythm of the body, rhythm of the brain: exploring the relationship between interoception and time perception through auricular vagus nerve stimulation (taVNS)
De Martino, Maria Luisa; Leemhuis, Erik; Scuderi, Angelica; Pazzaglia, Mariella - 04d Abstract in atti di convegno
congresso: Fens Forum 2024 (Vienna (Austria))
libro: Proceedings of the conference of the Federation of European Neuroscience Societies (Fens Forum 2024) - ()

11573/1726091 - 2024 - Unlocking the Brain's Clock: the effects of transauricular vagus nerve stimulation on time processing
De Martino, Maria Luisa; Leemhuis, Erik; Scuderi, Angelica; Pazzaglia, Mariella - 04d Abstract in atti di convegno
congresso: CogSci24 (Rotterdam, The Netherlands)
libro: Proceedings of the Annual Meeting of the Cognitive Science Society - ()

11573/1725941 - 2024 - Perceived body image in long-term mindfulness practitioners
De Pastina, Riccardo; Leemhuis, Erik; Scuderi, Angelica; De Martino, Maria Luisa; Raffone, Antonino; Pazzaglia, Mariella - 04d Abstract in atti di convegno
congresso: AIP Sperimentale 2024, 30° Congresso annuale (Noto)
libro: AIP Sperimentale 2024, 30° Congresso annuale Book of Abstracts - ()

11573/1726111 - 2024 - Modulation of neuropathic pain and tactile perception in spinal cord injury during an exoskeleton training program
Leemhuis, Erik; De Martino, Maria Luisa; Scuderi, Angelica; Giannini, Anna Maria; Pazzaglia, Mariella - 04d Abstract in atti di convegno
congresso: Fens Forum 2024 (Wien; Austria)
libro: Proceedings of the conference of the Federation of European Neuroscience Societies (Fens Forum 2024) - ()

11573/1726103 - 2024 - Examining the role of transauricular vagus nerve stimulation in balancing autonomic systems during cognitive tasks
Leemhuis, Erik; De Martino, Maria Luisa; Scuderi, Angelica; Pazzaglia, Mariella - 04d Abstract in atti di convegno
congresso: CogSci 2024 (Rotterdam; The Netherlands)
libro: Proceedings of the Annual Meeting of the Cognitive Science Societ - ()

11573/1710811 - 2024 - Redefining the Human Body Boundaries: The Impact of Assistive Devices on Body Representation
Scuderi, Angelica; De Martino, Maria Luisa; Leemhuis, Erik; Pazzaglia, Mariella - 04d Abstract in atti di convegno
congresso: 42° European Workshop on Cognitive Neuropsychology (Bressanone, Italia)
libro: Atti del 42° European Workshop on Cognitive Neuropsychology - ()

11573/1725531 - 2024 - Know your body by heart: a taVNS study on body awareness
Scuderi, Angelica; De Martino, Maria Luisa; Leemhuis, Erik; Pazzaglia, Mariella - 04d Abstract in atti di convegno
congresso: CogSci 2024 (Rotterdam, The Netherlands)
libro: Proceedings of the Annual Meeting of the Cognitive Science Society - ()

11573/1725532 - 2024 - Unravelling the role of the insula in apraxia: A systematic review of VLSM studies in stroke patients
Scuderi, Angelica; Favieri, Francesca; Leemhuis, Erik; Pazzaglia, Mariella - 04d Abstract in atti di convegno
congresso: XXX Congresso dell'Associazione Italiana di Psicologia - Sezione Sperimentale (Noto, Italia)
libro: Atti del XXX Congresso dell'Associazione Italiana di Psicologia - Sezione Sperimentale - ()

11573/1688864 - 2023 - LOST IN TIME: IL LEGAME TRA INTEROCEZIONE E PERCEZIONE DEL TEMPO IN PAZIENTI CON LESIONE AL MIDOLLO SPINALE
De Martino, Maria Luisa; Scuderi, Angelica; Leemhuis, Erik; Giannini, Anna Maria; Pazzaglia, Mariella - 04d Abstract in atti di convegno
congresso: XXIX Congresso dell'Associazione Italiana di Psicologia - Sezione Sperimentale (Lucca; Italia)
libro: Atti del XXIX Congresso dell'Associazione Italiana di Psicologia - Sezione Sperimentale - ()

11573/1687516 - 2023 - Beyond the wheelchair: how exoskeleton training redefines mobility and somatic sensation for incomplete spinal cord injury patients
De Martino, Maria Luisa; Tranquilli, Sara; Leemhuis, Erik; Scuderi, Angelica; Giannini, Anna Maria; Pazzaglia, Mariella - 04d Abstract in atti di convegno
congresso: 7th European Congress of NeuroRehabilitation (Lyon (FR))
libro: ECNR - 2023 - ()

11573/1688865 - 2023 - NEURAL HACKING FOR HEALTHY EATING: INVESTIGATING THE POTENTIAL OF TRANSAURICULAR VAGUS NERVE STIMULATION IN THE FOOD-PICTURES STROOP TASK
Favieri, Francesca; Scuderi, Angelica; Pazzaglia, Mariella - 04d Abstract in atti di convegno
congresso: XXIX Congresso dell'Associazione Italiana di Psicologia - Sezione Sperimentale (Lucca; Italia)
libro: Atti del XXIX Congresso dell'Associazione Italiana di Psicologia - Sezione Sperimentale - ()

11573/1687348 - 2023 - Embodiment of assistive tools in spinal cord injury: evidence from mental rotation tasks of wheelchairs and exoskeletons
Scuderi, Angelica; De Martino, Maria Luisa; Leemhuis, Erik; Giannini, Anna Maria; Pazzaglia, Mariella - 04d Abstract in atti di convegno
congresso: 7th European Congress of NeuroRehabilitation (Lyon (FR))
libro: ECNR - 2023 - ()

11573/1688863 - 2023 - RIDEFINIRE IL CORPO SUPPORTATO DA AUSILI PER LA MOBILITÀ: L'USO DI ESOSCHELETRI E CARROZZINE NELLE ROTAZIONI MENTALI DEI PAZIENTI CON LESIONE MIDOLLARE
Scuderi, Angelica; De Martino, Maria Luisa; Leemhuis, Erik; Giannini, Anna Maria; Pazzaglia, Mariella - 04d Abstract in atti di convegno
congresso: XXIX Congresso dell'Associazione Italiana di Psicologia - Sezione Sperimentale (Lucca; Italia)
libro: Atti del XXIX Congresso dell'Associazione Italiana di Psicologia - Sezione Sperimentale - ()

11573/1664595 - 2022 - An interoceptive perspective of time perception in spinal cord injury
De Martino, Maria Luisa; Leemhuis, Erik; Scuderi, Angelica; Pazzaglia, Mariella - 04d Abstract in atti di convegno
congresso: Neuroscience 2022 (San Diego, CA)
libro: 2022 Neuroscience Meeting Planner - ()

11573/1642900 - 2022 - Future Treatment of Neuropathic Pain in Spinal Cord Injury: The Challenges of Nanomedicine, Supplements or Opportunities?
Forte, Giuseppe; Giuffrida, Valentina; Scuderi, Angelica; Pazzaglia, Mariella - 01g Articolo di rassegna (Review)
rivista: BIOMEDICINES (Basel: MDPI) pp. 1373- - issn: 2227-9059 - wos: WOS:000816036800001 (12) - scopus: 2-s2.0-85132204530 (13)

11573/1664592 - 2022 - Rebuilding the body from the inside: interoception and the bodily self following spinal cord injuries
Scuderi, Angelica; De Martino, Maria Luisa; Leemhuis, Erik; Pazzaglia, Mariella - 04d Abstract in atti di convegno
congresso: Neuroscience 2022 (San Diego, CA)
libro: 2022 Neuroscience Meeting Planner - ()

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