ORCID iD: 0000-0002-5625-1170
Scopus Author ID: 6602786690
Web of Science ResearcherID: K-5325-2019
SCOPUS Metrics
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Publications: 68
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Total citations: 1715
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H-index: 20
Current Position
Researcher (Level III)
Institute of Molecular Biology and Pathology (IBPM) – National Research Council (CNR)
c/o Department of Biochemical Sciences “A. Rossi Fanelli”
Sapienza University of Rome
P.le Aldo Moro 5, 00185 Rome, Italy
Tel: +39 06 49913980
E-mail: angela.tramonti@cnr.it
Education and Qualifications
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1989 – High School Diploma (Scientific Studies)
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1995 – Laurea cum laude in Biological Sciences
Sapienza University of Rome
Thesis: “Expression and biochemical characterization of two glutamate decarboxylase isoforms from Escherichia coli”
Supervisor: Prof. Francesco Bossa
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1995–1996 – Post-graduate Training in Biological Chemistry and Molecular Biology
Department of Biochemical Sciences, Sapienza University of Rome
Tutors: Prof. Francesco Bossa, Prof. Mara Costa
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1996 – Research Stage
School of Molecular and Medical Biosciences, College of Cardiff, University of Wales (UK)
Focus: protein chemistry and enzyme kinetics
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1996–1999 – PhD in Biochemistry
Sapienza University of Rome
Thesis: “The glutamate decarboxylase from Escherichia coli: action, genetic regulation and physiological role”
Supervisor: Prof. Francesco Bossa
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1998 – Qualification as Biologist, Sapienza University of Rome
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1999–2002 – Master Degree in Biotechnology Applications
Sapienza University of Rome
Thesis: “Regulation studies on glutamate-dependent acid resistance system from Escherichia coli”
Supervisor: Prof. Francesco Bossa
National Scientific Qualification (ASN)
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2021 – Associate Professor (II level), General Biochemistry
Scientific Sector: 05/E1 – SSD BIO/10
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2021 – Associate Professor (II level), Molecular Biology
Scientific Sector: 05/E2 – SSD BIO/11
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2024 – Full Professor (I level), General Biochemistry
Scientific Sector: 05/E1 – SSD BIO/10
Research and Professional Experience
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1994–1996 – Laboratory training
Department of Biochemistry, Sapienza University of Rome
Research on expression and biochemical characterization of pyridoxal-5’-phosphate (PLP)-dependent enzymes
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1995 – Visiting Researcher
Institut für Pflanzengenetik und Kulturpflanzenforschung (IPK), Gatersleben, Germany
Supervisor: Dr. Bernhard Grimm
Funded by EU Human Capital and Mobility Programme
Activity: production of site-directed mutants of PLP-dependent enzymes
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1996 – Visiting Researcher
School of Molecular and Medical Biosciences, University of Wales, Cardiff (UK)
Supervisor: Prof. Robert A. John
Focus: enzyme kinetics
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1996–1999 – PhD Research Activity
Department of Biochemistry, Sapienza University of Rome
Research on gene expression regulation of the glutamate-dependent acid resistance system in Escherichia coli
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2000 – Postdoctoral Fellow
Department of Biochemistry, Sapienza University of Rome
MURST Project: “Genetic and molecular bases of microbial pathogenicity”
Supervisor: Prof. P. Visca
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2000–2001 – Postdoctoral Fellow
Department of Biochemistry, Sapienza University of Rome
Project: “Structure, action mechanism and physiological role of pyridoxal 5’-phosphate-dependent enzymes and peptides”
Research Grants and Projects
Principal Investigator
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2018–2021 – CNR–RFBR (Russia)
“Molecular characterization of enzymes involved in vitamin B1- and B6-dependent epilepsies”
Budget: €120,000
Russian partner: Prof. V. Bunik (Lomonosov Moscow State University, Moscow)
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2021–2023 – CNR–RFBR (Russia)
“Molecular basis of rare neurological disorders caused by mutations in pyridoxal-5'-phosphate- and thiamine-diphosphate-binding proteins”
Budget: €120,000
Russian partner: Dr. A. Graf (Lomonosov Moscow State University, Moscow)
Unit Leader / Responsible of Research Unit
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2021–2023 – Regione Lazio, POR FESR 2014–2020
“APTASER – Development of nucleic acid inhibitors of serine hydroxymethyltransferase in lung cancer”
PI: Prof. F. Cutruzzolà
Budget: €149,961
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2022–present – PRIN 2022
“RNA as a new player in the allosteric control of cellular metabolism: role of riboregulation in cancer”
Participation in Research Projects (selected)
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2020–2024 – AIRC
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2020–2022 – Italy–Poland Bilateral Project (CNR)
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2019 – Sapienza University of Rome
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2018–2020 – Istituto Pasteur–Fondazione Cenci-Bolognetti
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2015–2017 – AIRC
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2005–2007 – MIUR–PRIN
Editorial and Reviewer Activity
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Member of the Editorial Board of Life (MDPI)
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Guest Editor of the Special Issue “Novel and Innovative Methods for Measuring Enzyme Activity” (Life, MDPI)
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Reviewer for international journals including PLOS One, Scientific Reports, BBA, Frontiers in Microbiology, Frontiers in Molecular Biosciences, Journal of Pediatric Epilepsy, Frontiers in Oncology, International Journal of Molecular Sciences
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Reviewer for national and international research grant proposals
Teaching Activity
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Supervisor of numerous Bachelor’s and Master’s theses in Biology and Biotechnology
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Member of examination committees in Biochemistry for degree courses in Biological Sciences and Agro-Industrial Biotechnology, Sapienza University of Rome
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Member of PhD examination committees in Life Sciences
Research Interests
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Structure–function analysis of enzymes involved in vitamin B6 biosynthesis and salvage pathways
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Molecular basis of neonatal epileptic encephalopathy
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Structure–function relationships and gene expression regulation of PLP-dependent transcriptional regulators in bacteria
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Biochemical studies on serine hydroxymethyltransferase and its role in cancer metabolic reprogramming
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Identification and characterization of enzyme inhibitors
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Structure–function relationships of pyridoxal-5’-phosphate-dependent enzymes