ANGELA CARLONE

Dottoressa di ricerca

ciclo: XXXIV



Titolo della tesi: Valutazione della prevalenza delle complicanze micro e macrovascolari in una coorte di pazienti con diabete tipo 1 dopo 25 anni di follow-up

Background. Intensive glycemic control reduces the risk of retinopathy in people with type 1 diabetes (T1D). However, the impact of glycemic control during the peri-diagnostic period on the long-term risk of vascular complications is not known. Aim. To evaluate the association between the glycemic control obtained within the first year after T1D diagnosis and the long-term risk of chronic complications. Methods. We retrospectively studied a cohort of 150 subjects enrolled within 1 year of T1D diagnosis in intervention trials conducted by the IMmunotherapy DIABetes (IMDIAB) study group between 1994 and 2006 and still attending follow-up visits in one of the IMDIAB centers. Data regarding clinical and biochemical features at T1D onset and during the first year of the disease were collected at the time of enrollment in the IMDIAB studies. Follow-up data about clinical features including presence of chronic complications were collected between January 2020 and January 2021 through the consultation of medical records. Results: After a median follow-up of 25 [25th-75th percentiles: 22-28] years, 26 (17.3%) people had developed diabetic retinopathy (DR), 10 (6.6%) peripheral neuropathy, 3 (2.0%) nephropathy and 2 (1.3%) macrovascular complications. People with DR showed significantly higher updated first-year HbA1c (6.8 [6.2-7.8] % vs 6.3 [5.7-7.2] %, p=0.037) and higher HbA1c at follow-up (8.0 [6.9-8.9]% vs 7.2 [6.5-7.8]%, p=0.005) compared to people free from DR. Higher updated first-year HbA1c was also a significant predictor of higher HbA1c at follow-up (beta-coefficient: 0.24, p=0.015). The association between the updated first-year HbA1c and DR did not significantly change after adding HbA1c at follow-up and disease duration in the multivariate model. Conclusion: glycemic control obtained during the very first year after T1D onset is associated with long-term risk of diabetic retinopathy independently from subsequent glycemic control and other confounders.

Produzione scientifica

  • 11573/489460 - 2012 - Childhhood obesity, insulin resistance and increased cardiovascular risk [Obesità infantile, insulino-resistenza ed aumentato rischio cardiovascolare] (01a Articolo in rivista)
    CARLONE, ANGELA; VENDITTI, CHIARA; ZAMPETTI, SIMONA; SPOLETINI, MARIA LUISA; CAPIZZI, MARCO; BUZZETTI, RAFFAELLA
  • 11573/1021219 - 2017 - Effects on the incidence of cardiovascular events of the addition of pioglitazone versus sulfonylureas in patients with type 2 diabetes inadequately controlled with metformin (TOSCA.IT): a randomised, multicentre trial (01a Articolo in rivista)
    SESTI, GIORGIO; LUCISANO, GIUSEPPE; SACCO, MICHELE; SIGNORINI, STEFANO; BUZZETTI, RAFFAELLA; PUGLIESE, GIUSEPPE; RICCARDI, GABRIELE; LUCISANO, GIUSEPPE; SACCO, MICHELE; SIGNORINI, STEFANO; RICCARDI, GABRIELE; TARANTINO, LUCIA; MONTESI, LUCA; ITALIA, SALVATORE; SCICCHITANO, CATERINA; TOMASI, FRANCO; ANNUNZIATA, FRANCESCA; BUZZETTI, RAFFAELLA; CARLONE, ANGELA; POTENZIANI, STELLA; VENDITTI, CHIARA; FOFFI, CHIARA; CIPOLLONI, LAURA; MORETTI, CHIARA; LETO, GAETANO; PETRACHI, FRANCESCA; VITALE, MARTINA; RANGEL, GRAZIELA; SALVI, LAURA; CORDONE, SAMANTHA; SIMONELLI, PAOLA; MEGGIORINI, MARILLA; FRASHERI, AURORA; DI PIPPO, CLELIA; RINALDI, MARIA ELENA; NIGI, LAURA; FORTE, ELISA; POTENZIANI, STELLA; CUTOLO, MICHELE WALTER
  • 11573/1184860 - 2018 - Livelli aumentati di sclerostina in corso di diabete mellito tipo 2 e complicanze macrovascolari (04d Abstract in atti di convegno)
    D'ONOFRIO, LUCA; LUCANTONI, FEDERICA; LETO, GAETANO; CAMPAGNA, GIUSEPPE; FOFFI, CHIARA; MORETTI, CHIARA; CARLONE, ANGELA; MIGNOGNA, CARMEN; LUORDI, CECILIA; ZAMPETTI, SIMONA; LENZI, ANDREA; BUZZETTI, RAFFAELLA
  • 11573/485810 - 2011 - Effectiveness of therapeutic-educational re-training in patients affected by type 1 diabetes treated with CSII (continuous subcutaneous insulin infusion) (04d Abstract in atti di convegno)
    CARLONE, ANGELA; BUZZETTI, RAFFAELLA
  • 11573/1206405 - 2019 - Sclerostin is expressed in the atherosclerotic plaques of patients who undergoing carotid endarterectomy (01a Articolo in rivista)
    LETO, GAETANO; D'ONOFRIO, LUCA; LUCANTONI, FEDERICA; ZAMPETTI, SIMONA; CAMPAGNA, GIUSEPPE; FOFFI, CHIARA; MORETTI, CHIARA; CARLONE, ANGELA; PALERMO, ANDREA; LEOPIZZI, MARTINA; PORTA, NATALE; LENZI, ANDREA; DELLA ROCCA, CARLO; BUZZETTI, RAFFAELLA
  • 11573/1692008 - 2023 - Glycated haemoglobin in the first year after diagnosis of type 1 diabetes is an independent risk factor for diabetic retinopathy: The IMDIAB 25 years follow-up study (01f Lettera, Nota)
    MADDALONI, ERNESTO; CARLONE, ANGELA; CAVALLO, MARIA GISELLA; BARCHETTA, ILARIA; MORANO, SUSANNA; MORETTI, CHIARA; CORAGGIO, LUCIA; BUZZETTI, RAFFAELLA
  • 11573/1409669 - 2020 - Effects of covid-19 lockdown on glucose control: continuous glucose monitoring data from people with diabetes on intensive insulin therapy (01f Lettera, Nota)
    MADDALONI, ERNESTO; CORAGGIO, LUCIA; CARLONE, ANGELA; BUZZETTI, RAFFAELLA
  • 11573/1347607 - 2019 - Chitotriosidase Activity Is Inversely Associated with Diastolic Blood Pressure and HbA1c but Not with Arterial Stiffness in Patients with Type 2 Diabetes without Complications (04d Abstract in atti di convegno)
    D'ONOFRIO, LUCA; LUORDI, CECILIA; MIGNOGNA, CARMEN; CARLONE, ANGELA; MORETTI, CHIARA; TARTAGLIONE, LIDA; MADDALONI, ERNESTO; LETO, GAETANO; MAZZAFERRO, SANDRO; BUZZETTI, RAFFAELLA
  • 11573/384814 - 2011 - Clinical Update on the Use of Immuno Modulators (antiCD3, GAD, Diapep277, Anti-IL1) in Type 1 Diabetes (01a Articolo in rivista)
    CARLONE, ANGELA; BUZZETTI, RAFFAELLA
  • 11573/1025036 - 2018 - Dietary intake and major food sources of polyphenols in people with type 2 diabetes. The TOSCA.IT study (01a Articolo in rivista)
    MASULLI, MASSIMILIANO; NICOLUCCI, ANDREA; POTENZIANI, STELLA; SERRA, RICCARDO; BUZZETTI, RAFFAELLA; VENDITTI, CHIARA; POTENZIANI, STELLA; CARLONE, ANGELA; RINALDI, MARIA ELENA; TOMASI, FRANCO; PUGLIESE, GIUSEPPE; SALVI, LAURA; RANGEL, GRAZIELA; VITALE, MARTINA; TARANTINO, LUCIA; SCICCHITANO, CATERINA; PETRACHI, FRANCESCA; FORTE, ELISA; POTENZIANI, STELLA; MONTESI, LUCA
  • 11573/1521661 - 2021 - Decrease of coronary heart disease risk with GLP1-receptor agonists or SGLT2 inhibitors therapy in patients with type 2 diabetes in primary cardiovascular prevention: a 24 months follow-up study (01a Articolo in rivista)
    D'ONOFRIO, LUCA; MIGNOGNA, CARMEN; CARLONE, ANGELA; MORETTI, CHIARA; MADDALONI, ERNESTO; BUZZETTI, RAFFAELLA
  • 11573/1573592 - 2021 - Short-term safety profile of Sars-Cov2 vaccination on glucose control. Continuous glucose monitoring data in people with autoimmune diabetes (01a Articolo in rivista)
    D'ONOFRIO, LUCA; CORAGGIO, LUCIA; ZURRU, ANNALISA; CARLONE, ANGELA; MIGNOGNA, CARMEN; MORETTI, CHIARA; MADDALONI, ERNESTO; BUZZETTI, RAFFAELLA
  • 11573/1639821 - 2022 - Diastolic Pressure And Acr Are Modifiable Risk Factors Of Arterial Stiffness In T2DM Without Cardiovascular Disease (01a Articolo in rivista)
    TARTAGLIONE, LIDA; ROTONDI, SILVERIO; MADDALONI, ERNESTO; MIGNOGNA, CARMEN; D'ONOFRIO, LUCA; ZAMPETTI, SIMONA; CARLONE, ANGELA; MUCI, MARIA LUISA; MASTROLUCA, DANIELA; FASSINO, VALERIA; BUZZETTI, RAFFAELLA; MAZZAFERRO, SANDRO
  • 11573/1550017 - 2018 - EVALUATION OF VASCULAR DAMAGE BY CARDIO-ANKLE VASCULAR INDEX (CAVI) IN TYPE 2 DIABETES PATIENTS (01h Abstract in rivista)
    TARTAGLIONE, LIDA; LETO, GAETANO; ROTONDI, SILVERIO; CARLONE, ANGELA; D'ONOFRIO, LUCA; MUCI, MARIA LUISA; MASTROLUCA, DANIELA; BUZZETTI, RAFFAELLA; MAZZAFERRO, SANDRO
  • 11573/1181344 - 2018 - Espressione di sclerostina nelle placche aterosclerotiche di pazienti sottoposti a tea carotidea (04d Abstract in atti di convegno)
    D'ONOFRIO, LUCA; LETO, GAETANO; LUCANTONI, FEDERICA; CAMPAGNA, GIUSEPPE; FOFFI, CHIARA; MORETTI, CHIARA; CARLONE, ANGELA; MIGNOGNA, CARMEN; LUORDI, CECILIA; PALERMO, ANDREA; DELLA ROCCA, CARLO; BUZZETTI, RAFFAELLA

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