Phd in MORPHOGENESIS AND TISSUE ENGINEERING

email: andrea.fuso@uniroma1.it
phone: 06-7232310
building: RM009
room: 1

Name: Andrea Fuso Date: January, 2024


Education and Employment:

1991-1997: Degree (MS) in Biological Sciences (Cum Laude), Sapienza University of Rome, Rome, Italy
1997-2001: Ph.D. in Enzymology, University of L’Aquila, L’Aquila, Italy
2002-2010: Postdoctoral Fellow (Assegno di Ricerca) in Neuroscience, Dept. of Surgery “P. Valdoni” and Dept. of Psychology, Sapienza University of Rome, Rome, Italy
2010-2013: Lecturer in Clinical Pathology, Post-graduation School of Clinical Pathology, Sapienza University of Rome, Rome, Italy
2012-2015: Assistant Professor (RTD), Dept. of Psychology, Sect. Neuroscience, Sapienza University of Rome (RTDa; 1/10/2012 - 30/9/2015)
2013-2017: Scientist, S. Lucia Foundation, Rome, Italy - Lab. of Lipid Neurochemistry (Lab. Head prof. M. Maccarrone)
2013: National Qualification (Abilitazione Scientifica Nazionale, ASN) as Associate Professor in Applied Biology (SSD 05/F1 – Bio/13; until 22/01/2020); National Qualification as Associate Professor in Biochemistry (SSD 05/E1 – Bio/10; until 16/06/2020).
2015-2018: Scientific Consultant to Lo.Li.Pharma S.r.l., Rome, Italy
2015-2018: Guest researcher, Dept. of Surgery, Sapienza University of Rome, Italy
2018-2021: Assistant Professor (RTD), Dept. of Experimental Medicine, Sapienza University of Rome (RTDb; 1/11/2018 - 31/10/2021)
2021-pres.: Associate Professor (PA) in Clinical Biochemistry and Clinical Molecular Biology, Dept. of Experimental Medicine, Sapienza University of Rome



Other professional experiences:

1991-1997: Undergraduate student, Dept. of Cellular Biotechnology and Hematology, Sapienza University of Rome, Rome, Italy
Study of the methylation status of 5’-flanking and exon I of the regulatory gene myogenin, during muscular differentiation in vitro. Study on the effects of hypomethylating drugs during muscle differentiation.
1997-2001: Ph.D. student, Dept. of Cellular Biotechnology and Hematology, Sapienza University of Rome, and University of L’Aquila, Italy.
Further studies on the effect and mechanism of action of hypomethylating drugs on DNA methylation during muscle differentiation.
2002-2010: Postdoctoral Fellow in Neuroscience, Dept. of Surgery “P. Valdoni” and Dept. of Psychology, Sapienza University of Rome, Rome, Italy.
Studies on One-carbon metabolism alterations in vitro and in vivo by modulation of B vitamins supplementation and use of hypomethylating and hypermethylating drugs. Alzheimer’s Disease: study of the molecular mechanisms of homocysteine toxicity; role of DNA and protein methylation in amyloidogenesis and fibrillogenesis.
2010-2012.: Contract Researcher and Lecturer in Clinical Pathology, Dept. of Surgery “P. Valdoni”, Sapienza University of Rome, Rome, Italy.
Studies on the modulation of non-CpG methylation in in vitro and in vivo models. Studies on the role of One-carbon metabolism in Alzheimer’s Disease in in vitro and in vivo models and in human samples. Studies on the DNA methylation of PSEN1 gene in relation to alterations of One-carbon metabolism. Studies on the effect of B vitamins on PARP activity and on RAGE and LRP1 regulation. Role of One-carbon metabolism on animal models of autism and Rett syndrome.

Main research interest

General Areas:
●Epigenetics
●One-Carbon Metabolism
●Neurodegeneration
●Nutrition and disease

Applicative fields:
●Alzheimer's disease
●Rett Syndrome
●Autism
●Muscle differentiation


Current and past research support

Active research projects:
- Gnosis by Lesaffre, grant for studies on S-adenosylmethionine and Vitamin K in neurodegeneration and neuroinflammation; € 19.000. Role: PI

Completed research projects:
2022: Sapienza University, Progetto di Ricerca Medio #RM11916B88D5E704. Role: participant.
2022: Sapienza University, Finanziamento per convegni, seminari, workshop 2022 #CC1221814E60CADF. Role: PI
2013 – 2016: Sapienza University Grant, title: Aggregazione di fibrille amiloidi nella malattia di Alzheimer: processi rapidi e processi lenti; Total budget: € 11.000/year. Role: Unit PI.
2013 – 2015: FP7 Grant, title: DEVELAGE; Total budget: € 4.000.000. Role: Co-investigator.
2007 – 2011: Research project financed by Gnosis s.p.a. for the development of researches on “Molecular mechanisms and possible clinical applications of S-adenosylmethionine”. About 100.000 € per year. Role: Co-Investigator (PI: Scarpa S.)
2002 – 2003: Young researchers grant of the Sapienza University of Rome; study of the DNA methylation mechanisms in Alzheimer’s Disease models. Role: PI


Committee responsibilities

Referee for the Grant Programs of the:
Alzheimer’s Association, Swiss National Science Foundation, Parkinson’s UK, Lise Meitner-Program, Austrian Science Fund, UK Medical Research Council, MIUR, Università di Modena e Reggio Emilia, Unicampania, Università di Verona, PRIN


Editorial responsibilities (Reviewer)

Neurobiology of Aging, Journal of Alzheimer’s Disease, Journal of Neurochemistry, Current Alzheimer Research, PlosOne, Current Pharmaceutical Design, AGE, Epigenetics, International Journal of Developmental Neuroscience, Archives of Medical Research, Amino Acids, Frontiers in Aging Neuroscience, Frontiers in Genetics, WIRE, European Journal of Neuroscience, Cancer Biomarkers, Expert Review of Molecular Diagnostics, Epigenetics, Epigenomics, Longevity & Healthspan.


Editorial responsibilities (Editorial boards)

Clinical Epigenetics, Epigenomes, Frontiers in Molecular Biosciences, Frontiers in Environmental Science, Frontiers in Ecology and Evolution, Annals of Nutritional Disorders & Therapy


Teaching

1998-2001: Guest lecturer at “Chemistry and Introductory Biochemistry” course at Nurse Training College “San Giovanni di Dio”.
2002-2008: Guest lecturer at post-graduation courses (Scuola di Specializzazione) of Hematology and of Clinical Pathology, Sapienza University of Rome
2010-pres.: Guest lecturer at Sapienza University of Rome School of Medicine; seminars on “Molecular mechanisms of Alzheimer’s Disease”
2011-2012: Techniques of Cellular and Molecular Biology, post-graduation course of “Clinical Pathology”, Sapienza University of Rome.
2012-pres.: Epigenetics, Master in “Stress, sport, nutrition: new diagnostic and therapeutic approaches for fitness, wellness, prevention and rehabilitation”, Medical and Pharmaceutical School, Sapienza University of Rome.
2013-2015: Molecular basis of the Life (classes of Biology and Genetics, Bio/13), School of Therapists of Child Neuropsychomotricity, Sapienza University of Rome
2015-2016: Molecular basis of the Life (classes of Biochemistry, Bio/10, and Biology, Bio/13), Schools of Nursing (S. Andrea, Pomezia, Frosinone), Sapienza University of Rome
2015-2016: Epigenetics, Master in Methodology for Therapeutic Intervention in Neurology, Sapienza University of Rome
2016-2019: Epigenetics and Dementia, Master in Diagnosi e terapia integrata della malattia di Alzheimer e delle altre demenze, Tor Vergata University, Rome
2019-pres: Clinical Biochemistry, School of Medicine, Sapienza University of Rome
2019-pres: Biochemistry, Nurse Science, Sapienza University of Rome.
2020-pres: Molecular Biology, School for Biomedical Laboratory Technicians, Sapienza University of Rome.

Mentoring

2001-pres: more than 15 undergraduate students (Biological Sciences, Biotechnology) and PhD students (Human Biology)

Membership to scientific societies:

2007-2018.: International Society to Advance Alzheimer Research and Treatment (ISTAART)
2008-2018: Society for Neuroscience (SfN)
2008-pres.: Italian Society for Neuroscience (SINS)
2010-pres.: Epigenetics Society (ES); Board of Directors member since 2015
2014-pres.: Associazione Italiana per la Ricerca sull'Invecchiamento Cerebrale (AIRIC)
2019-pres.: Società Italiana di Biochimica Clinica e Biologia Molecolare Clinica (SIBIOC)
2019-pres.: Società Italiana di Biochimica (SIB)


Honors:

2001: Fellowship to attend the course “Technologies in Oncology”, FORMIT Foundation
2009: Invited Chair at the symposium “Epigenetics of Alzheimer's Disease”, 9th International Conference on Alzheimer's Disease (ICAD) (Wien, Austria)
2009: Organizer of the Symposium “Homocysteine in Alzheimer's Disease”, National Congress of the Italian Society for Neuroscience (Milan, IT)
2010: Travel Fellowship to attend the 10th International Conference on Alzheimer's Disease (ICAD) (Honolulu, HA, USA)
2011: Invited Plenary Speaker, 8th International Conference on Homocysteine Metabolism (Lisbon, Portugal)
2011: Travel Fellowship to attend the 11th International Conference on Alzheimer's Disease (ICAD) (Paris, France)
2012: Invited Plenary Speaker, conference on Advances and Controversies in B-Vitamins and Choline (Leipzig, Germany)
2012: Fellowship from Unipharma to perform studies on a schizophrenia animal model
2013: Invited Plenary Speaker, Keystone Symposia on “Nutrition, Epigenetic and Human Disease” (Santa Fe, NM, USA)
2013: Organizer and chair of the Symposium “Environment, epigenetics and neurodegeneration”, National Conference of the Italian Society for Neuroscience (Rome, IT)
2013: Chair of the Symposium “Neuroepigenetics: Environmental determinants of brain and behavior”, Joint Italian-Israeli symposium at National ISFN Conference (Eilat, IL)
2014: Invited Plenary Speaker, 20th Symposium on Neurobiology and Neuroendocrinology of Aging (Bregenz, AT)
2015: Board of Directors, Epigenetic Society (ES)
2015: Member of the Scientific/Organizing Committee, “Nanoscience and Nanotechnology” International Conference (Frascati, IT)
2016: Member of the Scientific/Organizing Committee, “52° Congresso della Società Italiana di Neuropatologia e Neurobiologia Clinica” (Rome, IT)
2023: Chair and head of the Organizing Committee of the 1st Epigenetics Society International Meeting (Rome, IT)

Invited lectures:

“Epigenetic mechanisms in AD”, RepEat Project - University of Teramo, November 13 2017; host Dr. Claudio D’Addario
“CpG and non-CpG methylation in Alzheimers’ Disease”; The Hebrew University of Jerusalem, May 19 2016; host Dr. Aron Troen.
“CpG and non-CpG methylation patterns of PSEN1 during neurodevelopment and neurodegeneration in mice and humans”; CIBIO, University of Trento, February 27 2015; host Dr. Margherita Grasso.
“DNA methylation and mRNA expression patterns of PSEN1 during neurodevelopment and neurodegeneration in mice and humans”; Dept. of Cellular Biology and Neurosciences, Istituto Superiore di Sanità, Rome, February 2 2015; host Dr. Bianca De Filippis
“Presenilin1 CpG and non-CpG methylation in Alzheimer’s Disease”; Dept. of Biochemical Sciences, Sapienza University of Rome - January 16 2015; host Dr. Maria D’Erme
“Looking for Alzheimer's Disease mechanisms: one-carbon metabolism and methylation reactions”; Dept. of Scienze e Biotecnologie Medico-Chirurgiche, Sapienza University of Rome - Latina, February 8 2011; host Dr. Rita Businaro.
“Role of methylation metabolism in Alzheimer’s Disease”; Mario Negri Institute for Pharmacological Research, February 23 2010; host Dr. Ugo Lucca.
“Methylation imbalance as a pathway to disease: the Alzheimer's Disease model”; Dept. Of Histology and Medical Embryology, Sapienza University of Rome, November 25, 2009; host Dr. Carla Boitani.
“DNA methylation and Alzheimer’s Disease”; Center for Research in Neurobiology “Daniel Bovet”, Sapienza University of Rome, June 8, 2009; host Dr. Antonella De Jaco.
“Homocysteine cycle, methylation and Alzheimer’s Disease"; Dept. of Pharmacology, Chemiotherapy and Medical Toxicology, CNR Center, University of Milan, September 27, 2006; host Dr. Carlo Sala.


Patents:

S-Adenosylmethionine and derivatives thereof for the treatment and prevention of Alzheimer’s Disease. Patent n° WO2001IT00528.
Use of S-adenosylmethionine (SAM) e Superoxidedismutase (SOD) for the preparation of drugs for the treatment of Alzheimer’s Disease. Application n° 08425123.0


Scientific Collaborations:

I. Ferrer, Institute of Neuropathology, Bellvitge University Hospital, Hospitalet de Llobregat (Barcelona), Spain
E. Aronica, Amsterdam University, Netherland
G. Kovacs, Medical University Wien, Austria
A. Troen, Yuval Dor, Benjamin Glaser, Institute of Biochemistry, Food Science and Nutrition, Hebrew University of Jerusalem
F. Gosselet, Université d’Artois, Lens, France
E. Rodrigues, iMed.UL - Research Institute for Medicines and Pharmaceutical Sciences, Faculty of Pharmacy, University of Lisbon, Portugal
M. D’Erme, L. Mosca, Dept. Biochemistry, Sapienza University of Rome
Stefano Gustincich, SISSA, Trieste
L. Ricceri, G. Laviola, B. De Filippis, Dept. Cell Biology and Neuroscience, Istituto Superiore di Sanità, Rome
R. Businaro, Dept. Scienze e Biotecnologie Medico-Chirurgiche, Sapienza University of Rome


Languages:

Italian: mother tongue
English: fluent, written and spoken.
French: fluent, spoken; good, written




Other Relevant and non-professional achievements:

Emergency Responder (BLS – EFR)
Chair of the Sapienza local head office of ARTeD (Associazione Ricercatori a Tempo Determinato) 2013-2015


Full Papers:
Int. publications: 85; h-index: 33; citations: 3250

Orticello M, Cavallaro RA, Antinori D, Raia T, Lucarelli M, Fuso A. Amyloidogenic and Neuroinflammatory Molecular Pathways Are Contrasted Using Menaquinone 4 (MK4) and Reduced Menaquinone 7 (MK7R) in Association with Increased DNA Methylation in SK-N-BE Neuroblastoma Cell Line. Cells. 2023 Dec 27;13(1):58. doi: 10.3390/cells13010058.
Fanfarillo F, Ferraguti G, Lucarelli M, Fuso A, Ceccanti M, Terracina S, Micangeli G, Tarani L, Fiore M. The Impact of Alcohol-Induced Epigenetic Modifications in the Treatment of Alcohol Use Disorders. Curr Med Chem. 2023 Oct 11. doi: 10.2174/0109298673256937231004093143. Epub ahead of print. PMID: 37828672.
Bruno SM, Blaconà G, Lo Cicero S, Castelli G, Virgulti M, Testino G, Pierandrei S, Fuso A, Cimino G, Ferraguti G, Eramo A, Lucarelli M. Quantitative Evaluation of CFTR Gene Expression: A Comparison between Relative Quantification by Real-Time PCR and Absolute Quantification by Droplet Digital PCR. Genes (Basel). 2023 Sep 9;14(9):1781. doi: 10.3390/genes14091781. PMID: 37761921; PMCID: PMC10531455.
Raia T, Armeli F, Cavallaro RA, Ferraguti G, Businaro R, Lucarelli M, Fuso A. Perinatal S-Adenosylmethionine Supplementation Represses PSEN1 Expression by the Cellular Epigenetic Memory of CpG and Non-CpG Methylation in Adult TgCRD8 Mice. Int J Mol Sci. 2023 Jul 19;24(14):11675. doi: 10.3390/ijms241411675. PMID: 37511434; PMCID: PMC10380323.
Frega A, Gentili C, Proietti S, Lepore E, Unfer V, Fuso A. Epigallocatechin gallate, folic acid, vitamin B12, and hyaluronic acid significantly increase apoptosis and p53 expression in HeLa cells. Eur Rev Med Pharmacol Sci. 2023 Jun;27(11):5240-5245. doi: 10.26355/eurrev_202306_32642. PMID: 37318498.
Di Paola V, Morrone M, Poli V, Fuso A, Pascale E, Adriani W. How Can CpG Methylations, and Pair-to-Pair Correlations between the Main (Gene) and the Opposite Strands, Suggest a Bending DNA Loop: Insights into the 5'-UTR of DAT1. Genes (Basel). 2023 Jan 11;14(1):190. doi: 10.3390/genes14010190. PMID: 36672931; PMCID: PMC9859484. IF 4.14
Miglione A, Raucci A, Amato J, Marzano S, Pagano B, Raia T, Lucarelli M, Fuso A, Cinti S. Printed Electrochemical Strip for the Detection of miRNA-29a: A Possible Biomarker Related to Alzheimer's Disease. Anal Chem. 2022 Nov 15;94(45):15558-15563. doi: 10.1021/acs.analchem.2c03542. Epub 2022 Nov 1. PMID: 36318963; PMCID: PMC9670028. IF 8
Fuchs C, Cosentino L, Urbinati C, Talamo MC, Medici G, Quattrini MC, Mottolese N, Pietraforte D, Fuso A, Ciani E, De Filippis B. Treatment with FRAX486 rescues neurobehavioral and metabolic alterations in a female mouse model of CDKL5 deficiency disorder. CNS Neurosci Ther. 2022 Nov;28(11):1718-1732. doi: 10.1111/cns.13907. Epub 2022 Aug 6. PMID: 35932179; PMCID: PMC9532911. IF 7.04
Tarashi S, Zamani MS, Bahramali G, Fuso A, Vaziri F, Karimipoor M, Fateh A, Siadat SD. RNA Expression Analysis of Mycobacterial Methyltransferases Genes in Different Resistant Strains of Mycobacterium tuberculosis. Iran Biomed J. 2022 May 1;26(3):240-51. doi: 10.52547/ibj.26.3.240. PMID: 35216515; PMCID: PMC9440689.
Tarashi S, Karimipoor M, Siadat SD, Fuso A. Epigenetic modifications in host-bacterial dialogues: more than meets the eye. Epigenomics. 2022 Jan;14(1):5-9. doi: 10.2217/epi-2021-0375. Epub 2021 Oct 22. PMID: 34676788. IF 4.36
Verna R, Alallon W, Murakami M, Hayward CPM, Harrath AH, Alwasel SH, Sumita NM, Alatas O, Fedeli V, Sharma P, Fuso A, Capuano DM, Capalbo M, Angeloni A, Bizzarri M. Analytical Performance of COVID-19 Detection Methods (RT-PCR): Scientific and Societal Concerns. Life (Basel). 2021 Jul 6;11(7):660. doi: 10.3390/life11070660. PMID: 34357032; PMCID: PMC8305061. IF 3.25
Minini M, Senni A, He X, Proietti S, Liguoro D, Catizone A, Giuliani A, Mancini R, Fuso A, Cucina A, Cao Y, Bizzarri M. miR-125a-5p impairs the metastatic potential in breast cancer via IP6K1 targeting. Cancer Lett. 2021 Nov 1;520:48-56. doi: 10.1016/j.canlet.2021.07.001. Epub 2021 Jul 3. PMID: 34229060. IF 9.76
Napoletani G, Vigli D, Cosentino L, Grieco M, Talamo MC, Lacivita E, Leopoldo M, Laviola G, Fuso A, d'Erme M, De Filippis B. Stimulation of the Serotonin Receptor 7 Restores Brain Histone H3 Acetylation and MeCP2 Corepressor Protein Levels in a Female Mouse Model of Rett Syndrome. J Neuropathol Exp Neurol. 2021 Feb 22;80(3):265-273. doi: 10.1093/jnen/nlaa158. IF 3.68
Fuso A, Troen AM. Environmental Epigenetics: Myth and Reality. Organisms. Journal of Biological Sciences 2021. 4(2):31-34. doi:https://doi.org/10.13133/2532-5876/17351.
Sterrantino M, Fuso A, Pierandrei S, Bruno SM, Testino G, Cimino G, Angeloni A, Lucarelli M. Quantitative Evaluation of CFTR Pre-mRNA Splicing Dependent on the (TG)mTn Poly-Variant Tract. Diagnostics (Basel). 2021 Jan 25;11(2):168. doi: 10.3390/diagnostics11020168 IF 3.99
Proietti S, Cucina A, Pensotti A, Fuso A, Marchese C, Nicolini A, Bizzarri M. Tumor reversion and embryo morphogenetic factors. Semin Cancer Biol. 2020 Sep 10:S1044-579X(20)30194-2. doi: 10.1016/j.semcancer.2020.09.005. IF 15.7
Tarashi S, Badi SA, Moshiri A, Ebrahimzadeh N, Fateh A, Vaziri F, Aazami H, Siadat SD, Fuso A. The inter-talk between Mycobacterium tuberculosis and the epigenetic mechanisms. Epigenomics. 2020 Mar;12(5):455-469. doi: 10.2217/epi-2019-0187. IF 4.78
Fuso A, Raia T, Orticello M, Lucarelli M. The complex interplay between DNA methylation and miRNAs in gene expression regulation. Biochimie. 2020 Jun;173:12-16. doi: 10.1016/j.biochi.2020.02.006. IF 4.08
Versele R, Corsi M, Fuso A, Sevin E, Businaro R, Gosselet F, Fenart L, Candela P. Ketone Bodies Promote Amyloid-β1-40 Clearance in a Human in Vitro Blood-Brain Barrier Model. Int J Mol Sci. 2020 Jan 31;21(3):934. doi: 10.3390/ijms21030934. IF 5.92
Fuso A, Raia T. The Relevance of Epigenetics in the SARS-CoV-2 Infection and COVID-19 Disease. Organisms. Journal of Biological Sciences. 2020; 4(1):11-14. ISSN 2532-5876. doi:https://doi.org/10.13133/2532-5876/16956.
Monti N, Cavallaro RA, Stoccoro A, Nicolia V, Scarpa S, Kovacs GG, Fiorenza MT, Lucarelli M, Aronica E, Ferrer I, Coppedè F, Troen AM, Fuso A. CpG and non-CpG Presenilin1 methylation pattern in course of neurodevelopment and neurodegeneration is associated with gene expression in human and murine brain. Epigenetics. 2020 Aug;15(8):781-799. doi: 10.1080/15592294.2020.1722917. IF 4.5
Lucarelli M, Ferraguti G, Fuso A. Active Demethylation of Non-CpG Moieties in Animals: A Neglected Research Area. Int J Mol Sci. 2019 Dec 12;20(24):6272. doi: 10.3390/ijms20246272. IF 4.56
Delfino D, Rossetti DV, Martelli C, Inserra I, Vincenzoni F, Castagnola M, Urbani A, Scarpa S, Fuso A, Cavallaro RA, Desiderio C. Exploring the brain tissue proteome of TgCRND8 Alzheimer's Disease model mice under B vitamin deficient diet induced hyperhomocysteinemia by LC-MS top-down platform. J Chromatogr B Analyt Technol Biomed Life Sci. 2019 Aug 15;1124:165-172. doi: 10.1016/j.jchromb.2019.06.005. IF 1.9
Cosentino L, Vigli D, Medici V, Flor H, Lucarelli M, Fuso A, De Filippis B. Methyl-CpG binding protein 2 functional alterations provide vulnerability to develop behavioral and molecular features of post-traumatic stress disorder in male mice. Neuropharmacology. 2019 Dec 1;160:107664. doi: 10.1016/j.neuropharm.2019.06.003. IF 5.25
Fuso A, Lucarelli M. CpG and Non-CpG Methylation in the Diet-Epigenetics-Neurodegeneration Connection. Curr Nutr Rep. 2019 Jun;8(2):74-82. doi: 10.1007/s13668-019-0266-1. IF 5.5
Micili SC, Goker A, Kuscu K, Ergur BU, Fuso A. α-Lipoic Acid Vaginal Administration Contrasts Inflammation and Preterm Delivery in Rats. Reprod Sci. 2019 Jan;26(1):128-138. IF 2.62
Dinicola S, Fuso A, Cucina A, Santiago-Reyes M, Verna R, Unfer V, Monastra G, Bizzarri M. Natural products - alpha-lipoic acid and acetyl-L-carnitine - in the treatment of chemotherapy-induced peripheral neuropathy. Eur Rev Med Pharmacol Sci. 2018 Jul;22(14) 4739-4754. IF 2.71
Pipolo S, Puglisi R, Mularoni V, Esposito V, Fuso A, Lucarelli M, Fiorenza MT, Mangia F, Boitani C. Involvement of sperm acetylated histones and the nuclear isoform of Glutathione peroxidase 4 in fertilization. J Cell Physiol. 2018 Apr;233(4):3093-3104. IF 4.52
Cavallaro RA, Nicolia V, Fiorenza MT, Scarpa S, Fuso A. S-Adenosylmethionine and Superoxide Dismutase 1 Synergistically Counteract Alzheimer's Disease Features Progression in TgCRND8 Mice. Antioxidants (Basel). 2017 Sep 30;6(4). IF 4.52
Dinicola S, Proietti S, Cucina A, Bizzarri M, Fuso A. Alpha-Lipoic Acid Downregulates IL-1β and IL-6 by DNA Hypermethylation in SK-N-BE Neuroblastoma Cells. Antioxidants (Basel). 2017 Sep 26;6(4). pii: E74. IF 4.52
Dinicola S, Santiago-Reyes M, Canipari R, Cucina A, Bizzarri M, Fuso A. Alpha-lipoic acid represses IL-1B and IL-6 through DNA methylation in ovarian cells. Pharma Nutrition. 2017, 5:77-83.
Nicolia V, Cavallaro RA, López-González I, Maccarrone M, Scarpa S, Ferrer I, Fuso A. DNA methylation profiles of selected pro-inflammatory cytokines in Alzheimer’s Disease. J Neuropathol Exp Neurol. 2017; 76:27-31. IF 3.43
Nicolia V, Ciraci V, Cavallaro RA, Ferrer I, Scarpa S, Fuso A. GSK3β 5’-flanking DNA methylation and expression in Alzheimer’s Disease patients. Curr Alz Res. 2017; 14:753-759. IF 3.15
Palladino G, Nicolia V, Kovacs GG, Canterini S, Ciraci V , Fuso A, Mangia F, Scarpa S, Fiorenza MT. Sexually dimorphic expression of reelin in the brain of a mouse model of Alzheimer disease. J Alz Dis. 2017; 61:359-367. IF 3.92
Bizzarri M, Fuso A, Dinicola S, Cucina A, Bevilacqua A. Pharmacodynamics and pharmacokinetics of inositol(s) in health and disease. Expert Opin Drug Metab Toxicol. 2016;12:1181-96. IF 2.83
Martire S, Fuso A, Mosca L, Forte E, Correani V, Fontana M, Scarpa S, Maras B, d’Erme M Bioenergetic impairment in animal and cellular models of Alzheimer’s disease: PARP-1 inhibition rescues metabolic dysfunctions. J Alz Dis. 2016;54:3017-24. IF 4.15
Fuso A, Iyer AM, van Scheppingen J, Maccarrone M, Scholl T, Hainfellner JA, Feucht M, Jansen FE, Spliet WG, Krsek P, Zamecnik J, Mühlebner A, Aronica E. Promoter-specific hypomethylation correlates with IL-1β overexpression in Tuberous Sclerosis Complex (TSC). J Mol Neurosci. 2016;59:464-70. IF 2.34
Businaro R, Corsi M, Azzara G, Di Raimo T, Laviola G, Romano E, Ricci L, Maccarrone M, Aronica E, Fuso A, Ricci S. Interleukin-18 modulation in autism spectrum disorders. J Neuroinflammation. 2016;13(1):2. IF 5.4
De Filippis B, Chiodi V, Adriani W, Lacivita E, Mallozzi C, Leopoldo M, Domenici MR, Fuso A, Laviola G. Long-lasting beneficial effects of central serotonin receptor 7 stimulation in female mice modeling Rett syndrome. Frontiers in Behavioral Neuroscience 2015. In Press. IF 4.16
Fuso A., Ferraguti G., Scarpa S., Ferrer I., Lucarelli M. Disclosing bias in bisulfite assay: MethPrimers underestimate high DNA methylation. PLoS One 2015. 10(2):e0118318. IF 3.53
López-González I, Schlüter A, Aso E, Garcia-Esparcia P, Ansoleaga B, LLorens F, Carmona M, Moreno J, Fuso A, Portero-Otin M, Pamplona R, Pujol A, Ferrer I. Neuroinflammatory Signals in Alzheimer Disease and APP/PS1 Transgenic Mice: Correlations With Plaques, Tangles, and Oligomeric Species. J Neuropathol Exp Neurol. 2015;74(4):319-44. IF 4.37
Persichilli S, Gervasoni J, Di Napoli A, Fuso A, Nicolia V, Giardina B, Scarpa S, Desiderio C, Cavallaro RA. Plasma Thiols Levels in Alzheimer's Disease Mice under Diet-Induced Hyperhomocysteinemia: Effect of S-Adenosylmethionine and Superoxide-Dismutase Supplementation. J Alzheimers Dis. 2015;44(4):1323-31. IF 3.61
Nicolia V, Lucarelli M, Fuso A. Environment, epigenetics and neurodegeneration: Focus on nutrition in Alzheimer's disease. Exp Gerontol. 2014 pii: S0531-5565(14)00281-2. IF 3.529
De Filippis B, Nativio P, Fabbri A, Ricceri L, Adriani W, Lacivita E, Leopoldo M, Passarelli F, Fuso A, Laviola G. Pharmacological stimulation of the brain serotonin receptor 7 as a novel therapeutic approach for Rett syndrome. Neuropsychopharmacology. 2014. 39(11):2506-18. IF 8.678
Romano E, De Angelis F, Ulbrich L, De Jaco A, Fuso A, Laviola G. Nicotine exposure during adolescence: cognitive performance and brain gene expression in adult heterozygous reeler mice. Psychopharmacology. 2014; 231: 1775-87. IF 4,061
Martire S., Fuso A., Rotili D., Tempera I., Giordano C., De Zottis I., Muzi A., Vernole P., Graziani G., Lococo E., Faraldi M., Maras B., Scarpa S., Mosca L., d'Erme M. PARP-1 modulates Amyloid Beta peptide-induced neuronal damage. Plos One. 2013; 8: e72169. IF 3,734
Romano E, Fuso A, Laviola G. Nicotine Restores Wt-Like Levels of Reelin and GAD67 Gene Expression in Brain of Heterozygous Reeler Mice. Neurotox Res. 2013; 24:205-15. IF 3,514; cit. 1
Fuso A. The 'golden age' of DNA methylation in neurodegenerative diseases. Clin Chem Lab Med. 2013; 51(3):523-34. IF 2,15; cit. 4
Coppedè F, Bosco P, Fuso A, Troen AM. Nutrition and Dementia. Curr Gerontol Geriatr Res. 2012. 2012: 926082.; cit. 1
De Filippis B, Ricceri L, Fuso A, Laviola G. Neonatal exposure to low dose corticosterone persistently modulates hippocampal mineralocorticoid receptor expression and improves locomotor/exploratory behavior in a mouse model of Rett syndrome. Neuropharmacology. 2013; 68:174-83. IF 4,677; cit. 3
Businaro R, Ippoliti F, Ricci S, Canitano N, Fuso A. Alzheimer’s Disease promotion by obesity-induced mechanisms and advisable guide lines for its prevention. Curr Gerontol Geriat Res. 2012. 2012:986823; cit. 6
Fuso A, Cavallaro RA, Nicolia V, Scarpa S. PSEN1 Promoter Demethylation in Hyperhomocysteinemic TgCRND8 Mice is the Culprit, not the Consequence. Curr Alzheimer Res. 2012; 9(5): 527-535. IF 4,95; cit. 5
Canterini S, Bosco A, Carletti V, Fuso A, Curci A, Mangia F, Fiorenza MT. Subcellular TSC22D4 localization in cerebellum granule neurons of the mouse depends on development and differentiation. Cerebellum. 2012;11(1):28-40. IF 3,29; cit. 4
Ricci S, Fuso A, Ippoliti F, Businaro R. Stress-induced cytokines and neuronal dysfunction in alzheimer's disease. J Alzheimer's Dis. 2012;28(1):11-24. IF 4,26; cit. 9
Grasso M, Fuso A, Dovere L, de Rooij DG, Stefanini M, Boitani C, Vicini E. Distribution of GFRA1-expressing spermatogonia in adult mouse testis. Reproduction. 2012 Mar;143(3):325-332. IF 3,094; cit. 10
Fuso A, Nicolia V, Ricceri L, Cavallaro RA, Isopi E, Mangia F, Fiorenza MT, Scarpa S. S-adenosylmethionine reduces the progress of the alzheimer-like features induced by B-vitamin deficiency in mice. Neurobiol Aging. 2012; 33: 1482.e1-1482.e16. IF 6,634; cit 16; Media release: Sapienza University website, Le Scienze, Le Scienze Web News, Quotidiano Sanità, La Stampa, MedicinaLive;
Ricceri L, De Filippis B, Fuso A, Laviola G. Cholinergic hypofunction in MeCP2-308 mice: Beneficial neurobehavioural effects of neonatal choline supplementation. Behav Brain Res. 2011;221(2):623-9. IF 3,220; cit. 6
Fuso A, Scarpa S. One-carbon metabolism and alzheimer's disease: Is it all a methylation matter? Neurobiol Aging. 2011;32(7):1192-5. IF 5,937; cit. 19
Fuso A, Nicolia V, Cavallaro RA, Scarpa S. DNA methylase and demethylase activities are modulated by one-carbon metabolism in alzheimer's disease models. J Nutr Biochem. 2011;22(3):242-51. IF 4,288; cit. 23
Fuso A, Nicolia V, Pasqualato A, Fiorenza MT, Cavallaro RA, Scarpa S. Changes in presenilin 1 gene methylation pattern in diet-induced B vitamin deficiency. Neurobiol Aging. 2011;32(2):187-99. IF 5,937; cit. 47
Milagre I, Nunes MJ, Moutinho M, Rivera I, Fuso A, Scarpa S, Gama MJ, Rodrigues E. Chromatin-modifying agents increase transcription of CYP46A1, a key player in brain cholesterol elimination. J Alzheimer's Dis. 2010;22(4):1209-21. IF 5,1; cit. 4
Borro M, Cavallaro RA, Gentile G, Nicolia V, Fuso A, Simmaco M, Scarpa S. One-carbon metabolism alteration affects brain proteome profile in a mouse model of alzheimer's disease. J Alzheimer's Dis. 2010;22(4):1257-68. IF 5,1; cit. 1
Fuso A, Ferraguti G, Grandoni F, Ruggeri R, Scarpa S, Strom R, Lucarelli M. Early demethylation of non-CpG, CpC-rich, elements in the myogenin 5′-flanking region: A priming effect on the spreading of active demethylation? Cell Cycle. 2010;9(19):3965-76. IF 4,12; cit. 17; Commented by M. Szyf in the same Issue.
Cavallaro RA, Fuso A, Nicolia V, Scarpa S. S-adenosylmethionine prevents oxidative stress and modulates glutathione metabolism in TgCRND8 mice fed a B-vitamin deficient diet. J Alzheimer's Dis. 2010;20(4):997-1002. IF 5,1; cit. 17
Nicolia V, Fuso A, Cavallaro RA, Di Luzio A, Scarpa S. B vitamin deficiency promotes tau phosphorylation through regulation of GSK3β and PP2A. J Alzheimer's Dis. 2010;19(3):895-907. IF 5.1; cit. 20
Ceccarelli F, Fuso A, Civitelli L, Ranieri E, Caprio G, Pagni P, Rengo M, Scarpa S. Urokinase expression in course of benign and malignant mammary lesions: Comparison between nodular and healthy tissues. J Cancer Res Clin Oncol. 2010;136(1):157-63. IF 2,217; cit. 1
Grisanti L, Falciatori I, Grasso M, Dovere L, Fera S, Muciaccia B, Fuso A, Berno V, Boitani C, Stefanini M, Vicini E. Identification of spermatogonial stem cell subsets by morphological analysis and prospective isolation. Stem Cells. 2009;27(12):3043-52. IF 7,531; cit. 46
Cucina A, Fuso A, Coluccia P, Cavallaro A. Nicotine inhibits apoptosis and stimulates proliferation in aortic smooth muscle cells through a functional nicotinic acetylcholine receptor. J Surg Res. 2008;150(2):227-35. IF 2,038; cit. 21
Fuso A, Nicolia V, Cavallaro RA, Ricceri L, D'Anselmi F, Coluccia P, Calamandrei G, Scarpa S. B-vitamin deprivation induces hyperhomocysteinemia and brain S-adenosylhomocysteine, depletes brain S-adenosylmethionine, and enhances PS1 and BACE expression and amyloid-β deposition in mice. Molecular and Cellular Neuroscience. 2008;37(4):731-46. IF 4,607; cit. 62; among the “Top 25 cited” in the Journal; commented in the Alzheimer Research Forum
D'Anselmi F, Cucina A, Cavallaro G, Bizzarri M, Cavallaro RA, Fuso A, Cavallaro A, Scarpa S. S-adenosylmethionine inhibits ubiquitin-proteasome system in vitro and on rat vascular smooth muscle cells. Protein Peptide Lett. 2008;15(1):58-62. IF 1,13; cit. 3
Fuso A, Cavallaro RA, Zampelli A, D'Anselmi F, Piscopo P, Confaloni A, Scarpa S. γ-Secretase is differentially modulated by alterations of homocysteine cycle in neuroblastoma and glioblastoma cells. J Alzheimer's Dis. 2007;11(3):275-90. IF 3,058; cit. 30
Cucina A, Scavo MP, Muzzioli L, Coluccia P, Ceccarini S, Fuso A, Cavallaro A. High density lipoproteins downregulate basic fibroblast growth factor production and release in minimally oxidated-LDL treated smooth muscle cells. Atherosclerosis. 2006;189(2):303-9. IF 3,777; cit. 11
Riccioli A, Starace D, Galli R, Fuso A, Scarpa S, Palombi F, De Cesaris P, Ziparo E, Filippini A. Sertoli cells initiate testicular innate immune responses through TLR activation. Journal of Immunology. 2006;177(10):7122-30. IF 6,387; cit. 41
Cavallaro RA, Fuso A, D'Anselmi F, Seminara L, Scarpa S. The effect of S-adenosylmethionine on CNS gene expression studied by cDNA microarray analysis. J Alzheimer's Dis. 2006;9(4):415-9. IF 3,058; cit. 15
Scarpa S, Cavallaro RA, D'Anselmi F, Fuso A. Gene silencing through methylation: An epigenetic intervention on alzheimer disease. J Alzheimer's Dis. 2006;9(4):407-14. IF 3,058; cit. 38
Fuso A, Scarpa S, Grandoni F, Strom R, Lucarelli M. A reassessment of semiquantitative analytical procedures for DNA methylation: Comparison of bisulfite- and HpaII polymerase-chain-reaction-based methods. Anal Biochem. 2006;350(1):24-31. IF 2,67; cit. 6
Desiderio C, Cavallaro RA, De Rossi A, D'Anselmi F, Fuso A, Scarpa S. Evaluation of chemical and diastereoisomeric stability of S-adenosylmethionine in aqueous solution by capillary electrophoresis. J Pharm Biomed Anal. 2005;38(3):449-56. IF 1,889; cit. 12
Fuso A, Seminara L, Cavallaro RA, D'Anselmi F, Scarpa S. S-adenosylmethionine/homocysteine cycle alterations modify DNA methylation status with consequent deregulation of PS1 and BACE and beta-amyloid production. Molecular and Cellular Neuroscience. 2005;28(1):195-204. IF 4,641; cit. 174; among the “Top 10 cited” in the Journal.
Scarpa S, Fuso A, D'Anselmi F, Cavallaro RA. Presenilin 1 gene silencing by S-adenosylmethionine: A treatment for alzheimer disease? FEBS Lett. 2003;541(1-3):145-8. IF 3,609; cit. 100
Fuso A, Cavallaro RA, Orrù L, Buttarelli FR, Scarpa S. Gene silencing by S-adenosylmethionine in muscle differentiation. FEBS Lett. 2001;508(3):337-40. IF 3,644; cit. 19
Lucarelli M, Fuso A, Strom R, Scarpa S. The dynamics of myogenin site-specific demethylation is strongly correlated with its expression and with muscle differentiation. J Biol Chem. 2001;276(10):7500-6. IF 7,258; cit. 74


Book Chapters:

Tarashi S., Omrani MD, Siadat SD, Fuso A. The Correlation of Microbiota and Host Epigenome in Tuberculosis. 2023. In “Tubercolosis”, Springer.
Fuso A. Aging and Disease: the epigenetic bridge. 2023. In: Tollefsbol, T. (ed), Epigenetics in Human Disease - III edition. Academic Press/Elsevier
Fuso A. Aging and Disease: the epigenetic bridge. 2017. In: Tollefsbol, T. (ed), Epigenetics in Human Disease - II edition. Academic Press/Elsevier
Fuso A. Epigenetica e demenza. In: Sancesario, G. And Caltagirone, C. (eds), Malattia di Alzheimer e Altre Demenze: Diagnosi e Terapia Integrata. 2017 In press. Società Editrice Universo
Fuso A and Domenichelli C. Diet, epigenetics and Alzheimer’s Disease. In: Patel, V. and Preedy, V.R. (eds), Handbook of nutrition, diets and epigenetics. Springer, In Press
Cavallaro R.A. and Fuso A. Next Generation Drugs in Alzheimer's Disease Treatment: From Benchtop to Bedside. 2013; 109-146. In: Atta-Ur-Rahman (ed), Frontiers in Clinical Drug Research – Alzheimer Disorders (vol. # 1), 465 pp. September 2013. Bentham Science Publications
Fuso A. Aging and Disease: the epigenetic bridge. 2012; 519-544. In: Tollefsbol, T. (ed), Epigenetics in Human Disease. 592 pp. June 2012. Academic Press/Elsevier


Rome, January 18, 2024 Andrea Fuso