ALICE NICOLAI

Dottoressa di ricerca

ciclo: XXXIV

Titolo della tesi: Anti-neoplastic effects of novel compounds on human head & neck squamous carcinoma cell lines.

Human head and neck squamous cell carcinomas (HNSCC) are the sixth most frequent cancers worldwide, characterized by recurrent metastasis and drug resistance. Aiming to develop a different and new therapy approach, we first analysed some novel synthesized aminopyrimidine compounds on several cancer cell lines, including HNSCC. These compounds were found to be good cancer cell proliferation inhibitors, especially a N-benzyl counterpart of RDS 3442, the reference molecule that in our earlier research demonstrated to be a promising negative regulator acting on tumor cell proliferation. Afterwards we evaluated the anti-neoplastic activity of two different agents: the first one is a new synthesized molecule, named RDS 60, structurally related to nocodazole, a tubulin targeting molecule, the second one is one of the most effective kinesin Eg5 inhibitors, K858. We proved that these two compounds are potential innovative anti-tumor agents for head and neck squamous cell carcinomas. We demonstrated that both agents inhibit various malignant cancer activities, by reducing tumor cell proliferation, but not the normal somatic cell one, blocking cancer cell cycle in G2/M phase, up-regulating cyclin B1, inducing apoptotic cell death and finally reversing the epithelial- mesenchymal transition, cell motility and extracellular matrix invasion in HNSCC.

Produzione scientifica

11573/1668131 - 2023 - Pyrrolyl and indolyl α-γ-diketo acid derivatives acting as selective inhibitors of human carbonic anhydrases IX and XII

Ialongo, Davide; Messore, Antonella; Madia, Valentina Noemi; Tudino, Valeria; Nocentini, Alessio; Gratteri, Paola; Giovannuzzi, Simone; Supuran, Claudiu T.; Nicolai, Alice; Scarpa, Susanna; Taurone, Samanta; Camarda, Michele; Artico, Marco; Papa, Veronica; Saccoliti, Francesco; Scipione, Luigi; Di Santo, Roberto; Costi, Roberta - 01a Articolo in rivista

rivista: PHARMACEUTICALS (Basel : MDPI, Molecular Diversity Preservation International, 2004-) pp. - - issn: 1424-8247 - wos: WOS:000941695000001 (2) - scopus: 2-s2.0-85148943598 (2)

11573/1542006 - 2022 - The role of congenital malformations of the thoracic outlet in the development of the syndrome

Artico, M; Santarelli, M T; Stevanato, G; Cirocchi, R; D'andrea, V; Nicolai, A; Cialone, G; Monteleone, G; Pindinello, I; Taurone, S - 01a Articolo in rivista

rivista: FOLIA MORPHOLOGICA (Gdańsk: "Via Medica") pp. 117-123 - issn: 1644-3284 - wos: WOS:000768747400001 (2) - scopus: 2-s2.0-85126072560 (2)

11573/1623472 - 2022 - The kinesin Eg5 inhibitor K858 exerts antiproliferative and proapoptotic effects and attenuates the invasive potential of head and neck squamous carcinoma cells

Nicolai, Alice; Taurone, Samanta; Carradori, Simone; Artico, Marco; Greco, Antonio; Costi, Roberta; Scarpa, Susanna - 01a Articolo in rivista

rivista: INVESTIGATIONAL NEW DRUGS (attuale: -SPRINGER, VAN GODEWIJCKSTRAAT 30, DORDRECHT, NETHERLANDS, 3311 GZ -Kluwer Academic Publishers / Massachusetts:PO Box 358, Accord Station:Hingham, MA 02018:(617)871-6600) pp. - - issn: 0167-6997 - wos: WOS:000771319900002 (6) - scopus: 2-s2.0-85126822611 (6)

11573/1493998 - 2021 - Design, synthesis and biological evaluation of new pyrimidine derivatives as anticancer agents

Madia, Valentina Noemi; Nicolai, Alice; Messore, Antonella; De Leo, Alessandro; Ialongo, Davide; Tudino, Valeria; Saccoliti, Francesco; De Vita, Daniela; Scipione, Luigi; Artico, Marco; Taurone, Samanta; Taglieri, Ludovica; Di Santo, Roberto; Scarpa, Susanna; Costi, Roberta - 01a Articolo in rivista

rivista: MOLECULES (Basel: MDPI Berlin: Springer, 1996-) pp. - - issn: 1420-3049 - wos: WOS:000615455300001 (17) - scopus: 2-s2.0-85101195321 (20)

11573/1490487 - 2021 - Oxidative stress and inflammation biomarker expression in obstructive sleep apnea patients

Maniaci, Antonino; Iannella, Giannicola; Cocuzza, Salvatore; Vicini, Claudio; Magliulo, Giuseppe; Ferlito, Salvatore; Cammaroto, Giovanni; Meccariello, Giuseppe; De Vito, Andrea; Nicolai, Alice; Pace, Annalisa; Artico, Marco; Taurone, Samanta - 01g Articolo di rassegna (Review)

rivista: JOURNAL OF CLINICAL MEDICINE (MDPI Publishing, Basel, Switzerland) pp. - - issn: 2077-0383 - wos: WOS:000468853100008 (6) - scopus: 2-s2.0-85100472281 (122)

11573/1553152 - 2021 - Anti-tumoral effects of a (1H-pyrrol-1-yl)methyl-1H-benzoimidazole carbamate ester derivative on head and neck squamous carcinoma cell lines

Nicolai, Alice; Madia, Valentina Noemi; Messore, Antonella; De Vita, Daniela; De Leo, Alessandro; Ialongo, Davide; Tudino, Valeria; Tortorella, Elisabetta; Scipione, Luigi; Taurone, Samanta; Pergolizzi, Tiziano; Artico, Marco; Di Santo, Roberto; Costi, Roberta; Scarpa, Susanna - 01a Articolo in rivista

rivista: PHARMACEUTICALS (Basel : MDPI, Molecular Diversity Preservation International, 2004-) pp. - - issn: 1424-8247 - wos: WOS:000666329400001 (7) - scopus: 2-s2.0-85110773299 (7)

11573/1478484 - 2021 - Tissue expression of androgen receptor splice variant 7 at radical prostatectomy predicts risk of progression in untreated nonmetastatic prostate cancer

Sciarra, Alessandro; Maggi, Martina; Salciccia, Stefano; Nicolai, Alice; Tortorella, Elisabetta; Giantulli, Sabrina; Magliocca, Fabio Massimo; Silvestri, Ida; Taglieri, Ludovica; Cattarino, Susanna; Scarpa, Susanna - 01a Articolo in rivista

rivista: ONCOLOGY (Basel: Karger 1967-) pp. 251-255 - issn: 0030-2414 - wos: WOS:000609338200001 (12) - scopus: 2-s2.0-85100006103 (10)

11573/1274892 - 2020 - Discovery of a pyrimidine compound endowed with antitumor activity

Taglieri, Ludovica; Saccoliti, Francesco; Nicolai, Alice; Peruzzi, Giovanna; Madia, Valentina Noemi; Tudino, Valeria; Messore, Antonella; Di Santo, Roberto; Artico, Marco; Taurone, Samanta; Salvati, Maurizio; Costi, Roberta; Scarpa, Susanna - 01a Articolo in rivista

rivista: INVESTIGATIONAL NEW DRUGS (attuale: -SPRINGER, VAN GODEWIJCKSTRAAT 30, DORDRECHT, NETHERLANDS, 3311 GZ -Kluwer Academic Publishers / Massachusetts:PO Box 358, Accord Station:Hingham, MA 02018:(617)871-6600) pp. 39-49 - issn: 0167-6997 - wos: WOS:000512107200005 (16) - scopus: 2-s2.0-85063345760 (17)

11573/1410068 - 2020 - Arthrogenic human synovial cysts: immunohistochemical profile of IL-1β, IL-6, TNF-α

Taurone, S; Santarelli, M T; De Ponte, C; Bardella, L; Ralli, M; Morselli, C; Nicolai, A; Greco, A; Ferretti, A; Artico, M - 01a Articolo in rivista

rivista: FOLIA MORPHOLOGICA (Gdańsk: "Via Medica") pp. - - issn: 1644-3284 - wos: WOS:000629153500019 (0) - scopus: 2-s2.0-85102910197 (1)

11573/1286484 - 2019 - Francesco Durante and the first intracranial tumor successfully operated on with long survival (1884)

Pizzinga, Annalisa; Pindinello, I.; Artico, M.; Nicolai, A.; Taurone, S.; Santoro, A. - 01g Articolo di rassegna (Review)

rivista: WORLD NEUROSURGERY (Amsterdam : Elsevier) pp. 308-313 - issn: 1878-8750 - wos: WOS:000475895100187 (0) - scopus: 2-s2.0-85066855001 (0)

11573/1339079 - 2019 - Dissecting the role of novel EZH2 inhibitors in primary glioblastoma cell cultures: effects on proliferation, epithelial-mesenchymal transition, migration, and on the pro-inflammatory phenotype

Stazi, G.; Taglieri, L.; Nicolai, Alice; Romanelli, A.; Fioravanti, R.; Morrone, S.; Sabatino, M.; Ragno, R.; Taurone, S.; Nebbioso, M.; Carletti, R.; Artico, M.; Valente, S.; Scarpa, S.; Mai, A. - 01a Articolo in rivista

rivista: CLINICAL EPIGENETICS (Berlin : Springer) pp. 1-17 - issn: 1868-7083 - wos: WOS:000501362500004 (52) - scopus: 2-s2.0-85076062797 (50)