Phd in LIFE SCIENCE

email: alessio.paone@uniroma1.it
phone: 0649910713.
building: CU027
room: T2

Part I – General Information

Full Name Alessio Paone
Affiliation Università di Roma La Sapienza
Address Piazzale Aldo Moro 5 00185 Roma
E-mail alessio.paone@uniroma1.it
Spoken Languages Italian/English

Part II – Education

Type Year Institution Notes (Degree, Experience,…)
University graduation 2005 “Roma3” University of Rome Laurea cum laude in Biology – Molecular biology-
Pre-doctorate training 2005-2006 “La Sapienza” University of Rome Dept of Histology and Medical Embryology Cell Biology/Biochemistry
PhD 2010 “La Sapienza” University of Rome Dept of Histology and Medical Embryology Scienze e Tecnologie Cellulari (Cell Biology)


Part III – Appointments

IIIA – Academic Appointments

Start End Institution Position
03/08/2020 today “La Sapienza” University of Rome Dept of Biochemical Sciences A. Rossi Fanelli Research associate Ricercatore a tempo determinato – full-time (art. 24 c.3-a L. 240/10) RTDB.
01/10/2017 03/08/2020 “La Sapienza” University of Rome Dept of Biochemical Sciences A. Rossi Fanelli Research associate Ricercatore a tempo determinato – full-time (art. 24 c.3-a L. 240/10) RTDA.
01/04/2013 30/09/2017 “La Sapienza” University of Rome Dept of Biochemical Sciences A. Rossi Fanelli Postdoctoral Researcher (assegnista di ricerca vincitore di concorso L. 240/10)
15/02/2010 15/03/2013 The Ohio State University, Columbus OH, USA Dept. of Molecular Virology, Immunology & Medical Genetics Postdoctoral Researcher

IIIB – Other Appointments and Qualifications


31/03/2016 31/03/2026 National Scientific Qualification (ASN) 05/E1 BIO10 Associate professor

Part IV – Teaching experience

Year Institution Course

2022-today “La Sapienza” University of Rome Biochemistry (4CFU), Degree course in Medicine and Surgery and member of the examination committee.
2021-today “La Sapienza” University of Rome Chemistry and propaedeutic biochemistry (2CFU) Degree course Medical radiology techniques and radiotherapy (coordinator)
2021-today “La Sapienza” University of Rome Cellular Biochemistry, Master’s Degree in Biochemistry (2CFU) and member of the examination committee.

2017-today “La Sapienza” University of Rome Chemistry and propaedeutic biochemistry Degree course in Medicine and Surgery (2CFU) and member of the examination committee.
2017-2021 “La Sapienza” University of Rome One Day Lab Safety short course for the Ph.D. School in Biochemistry (1CFU)


Teaching Assistant (TA) and Tutoring (T)
2015-today “La Sapienza” University of Rome Bioinformatics and Protein Engineering - Degree Courses in Medical Biotechnologies and Pharmaceutical Biotechnologies (TA)
2015-today “La Sapienza” University of Rome Molecular Biology - Biotechnology Degree Course (TA)
2014-today “La Sapienza” University of Rome Supervisor of students on thesis and Ph.D. Students (Pontecorvi V., Sun D., Garcia I., Bouzidi A. etc) T
2012-2013 The Ohio State University Rotating scholar supervisor (Sharpnack M.)T
2012-2013 The Ohio State University Supervisor of students on thesis (Riaz S.)T

Part V - Society memberberships, Awards and Honors

Year Title

2021 CONFERENCE-Frontiers in molecular Biology. Riboregulation of human serine hydroxymethyltransferase enzyme activity reveals a novel strategy to shape cell metabolism BEST POSTER PRIZE
2020- Italian Society of Biochemistry and Molecular Biology (SIB), “Tumor Biochemistry” group Board member

2019- Italian Society of Biochemistry and Molecular Biology (SIB)
2019 CONFERENCE-Molecular, cellular and translational approaches to differentiation and neoplastic transformation 17th June 2019 Florence. Exploiting serine hydroxymethyltransferase moonlighting function: novel perspectives to target serine metabolism in cancer cells BEST POSTER PRIZE

Part VI - Funding Information [grants as PI-principal investigator or I-investigator]

Year Title Program Grant value
2013 Inhibition of serinehydroxymethyltransferase and epigenetic reprogramming in lung cancer cell lines PI Avvio alla ricerca 3000
2013-2015 Probing the metabolic reprogramming of tumor cells by inhibition of Serine Hydroxymethyltransferase I AIRC IG 13150 (2013-2015) 179000
2016-2018 Serine/glycine one-carbon metabolism and cancer: biological role and inhibition of Serine Hydroxymethyltransferase I AIRC IG 16720 (2016-2018)


187000
2017 Infection, inflammation and metabolism: the missing link in prostate cancer I Ateneo Sapienza
RG11816430AF48E1
3000
2018 Dissecting Serine Hydroxymethyltransferase functions to target cancer metabolic reprogramming I Ateneo Sapienza
RP11715C644A5CCE 30000
2020 Humanized ferritin as a versatile tool for targeted nucleic acids delivery in cancer cells I Ateneo Sapienza
RP120172B85FA568 3000
2021 Role of metabolic niche in the metastatic potential of lung cancer cells PI Cenci Bolognetti Foundation
Istituto Pasteur Italy 40000
2022 Analysis of brain extracellular amino acids effect on the metastatic potential of lung and breast cancer cells PI Ateneo Sapienza 3000
2023 Dissecting the role of glutamate in the inflammatory response driving brain metastases formation PI Ateneo Sapienza 3000



Part VII – Editorial experience
Role journal
Review editor Frontiers Molecular Biosciences
Review editor Frontiers in Genetics
Guest Editor International Journal of Cell Biology (v.2014 ISSN 1687-8876)
Reviewer Oncotarget
Reviewer Frontiers in Genetics
Reviewer Oncoimmunology
Reviewer Journal of Nucleic Acid Investigation
Reviewer Frontiers in Oncology
Reviewer Cellular Physiology and Biochemistry
Reviewer Cancers
Reviewer Theranostics


Part VIII- Other experience - participation in selection committees

Member of several selection committee for the awarding research fellowship and research grant Department of Biochemical Sciences “A. Rossi Fanelli” Sapienza University of Rome.

Part IX – Principal Research Activities



Part X -Patents
WO Patent WO/2011/128,436 Combination of Hypoxia Inducible Factor -1 inhibitors and Toll-Like Receptor-3 agonists for treating solid tumors
A Filippini, A Riccioli, A Paone, E Ziparo




Part XI – Summary of Scientific Achievements

Product type Number Data Base Start End
Papers [international] 47 SCOPUS 2006 2023


Total Impact factor 278,781(JCR)
Average Impact factor 5,9
Total Citations 2916 (scopus)
Average Citations per Product 62,0 (scopus)
Hirsch (H) index 20 (scopus)
Normalized H index* 1,17

*H index divided by the academic seniority.


Part XII- COMPLETE list of publications

Publications
Extracellular serine empowers epidermal proliferation and psoriasis-like symptoms.
Cappello A, Mancini M, Madonna S, Rinaldo S, Paone A, Scarponi C, Belardo A, Zolla L, Zuccotti A, Panatta E, Pallotta S, Annicchiarico-Petruzzelli M, Albanesi C, Cutruzzolà F, Wang L, Jia W, Melino G, Candi E.
Sci Adv. 2022 Dec 16;8(50):eabm7902. doi: 10.1126/sciadv.abm7902. Epub 2022 Dec 16.
Retinoic acid-induced 1 gene haploinsufficiency alters lipid metabolism and causes autophagy defects in Smith-Magenis syndrome.
Turco EM, Giovenale AMG, Sireno L, Mazzoni M, Cammareri A, Marchioretti C, Goracci L, Di Veroli A, Marchesan E, D'Andrea D, Falconieri A, Torres B, Bernardini L, Magnifico MC, Paone A, Rinaldo S, Della Monica M, D'Arrigo S, Postorivo D, Nardone AM, Zampino G, Onesimo R, Leoni C, Caicci F, Raimondo D, Binda E, Trobiani L, De Jaco A, Tata AM, Ferrari D, Cutruzzolà F, Mazzoccoli G, Ziviani E, Pennuto M, Vescovi AL, Rosati J.
Cell Death Dis. 2022 Nov 21;13(11):981. doi: 10.1038/s41419-022-05410-7.
Inhibition of Glycolysis Impairs Retinoic Acid-Inducible Gene I-Mediated Antiviral Responses in Primary Human Dendritic Cells.
Zevini A, Palermo E, Di Carlo D, Alexandridi M, Rinaldo S, Paone A, Cutruzzola F, Etna MP, Coccia EM, Olagnier D, Hiscott J.
Front Cell Infect Microbiol. 2022 Jul 18;12:910864. doi: 10.3389/fcimb.2022.910864. eCollection 2022.
Nutrient Sensing and Biofilm Modulation: The Example of L-arginine in Pseudomonas.
Scribani Rossi C, Barrientos-Moreno L, Paone A, Cutruzzolà F, Paiardini A, Espinosa-Urgel M, Rinaldo S.
Int J Mol Sci. 2022 Apr 15;23(8):4386. doi: 10.3390/ijms23084386.
Anticancer Activity of (S)-5-Chloro-3-((3,5-dimethylphenyl)sulfonyl)-N-(1-oxo-1-((pyridin-4-ylmethyl)amino)propan-2-yl)-1H-indole-2-carboxamide (RS4690), a New Dishevelled 1 Inhibitor.
Coluccia A, Bufano M, La Regina G, Puxeddu M, Toto A, Paone A, Bouzidi A, Musto G, Badolati N, Orlando V, Biagioni S, Masci D, Cantatore C, Cirilli R, Cutruzzolà F, Gianni S, Stornaiuolo M, Silvestri R.
Cancers (Basel). 2022 Mar 7;14(5):1358. doi: 10.3390/cancers14051358.
Cytosolic localization and in vitro assembly of human de novo thymidylate synthesis complex.
Spizzichino S, Boi D, Boumis G, Lucchi R, Liberati FR, Capelli D, Montanari R, Pochetti G, Piacentini R, Parisi G, Paone A, Rinaldo S, Contestabile R, Tramonti A, Paiardini A, Giardina G, Cutruzzolà F.
FEBS J. 2022 Mar;289(6):1625-1649. doi: 10.1111/febs.16248. Epub 2021 Nov 12.
A conserved scaffold with heterogeneous metal ion binding site: the multifaceted example of HD-GYP proteins
Francesca Cutrzzolà, Alessandro Paiardini, Chiara Scribani Rossi, Sharon Spizzichino, Alessio Paone, Giorgio Giardina, Serena Rinaldo
Coordination Chemistry Reviews (in press)

Metformin Is a Pyridoxal-5'-phosphate (PLP)-Competitive Inhibitor of SHMT2.
Tramonti A, Cuyàs E, Encinar JA, Pietzke M, Paone A, Verdura S, Arbusà A, Martin-Castillo B, Giardina G, Joven J, Vazquez A, Contestabile R, Cutruzzolà F, Menendez JA.
Cancers (Basel). 2021 Aug 9;13(16):4009. doi: 10.3390/cancers13164009.
The Emerging Role of Amino Acids of the Brain Microenvironment in the Process of Metastasis Formation
Francesca Cutruzzolà, Amani Bouzidi, Francesca Romana Liberati, Sharon Spizzichino, Giovanna Boumis, Alberto Macone, Serena Rinaldo, Giorgio Giardina and Alessio Paone
Cancers 2021, 13(12), 2891; https://doi.org/10.3390/cancers13122891
Modelling of SHMT1 riboregulation predicts dynamic changes of serine and glycine levels across cellular compartments.
Monti M, Guiducci G, Paone A, Rinaldo S, Giardina G, Liberati FR, Cutruzzolá F, Tartaglia GG.
Comput Struct Biotechnol J. 2021 May 12;19:3034-3041. doi: 10.1016/j.csbj.2021.05.019. eCollection 2021.
High-Fat Diet Leads to Reduced Protein O-GlcNAcylation and Mitochondrial Defects Promoting the Development of Alzheimer's Disease Signatures.
Zuliani I, Lanzillotta C, Tramutola A, Barone E, Perluigi M, Rinaldo S, Paone A, Cutruzzolà F, Bellanti F, Spinelli M, Natale F, Fusco S, Grassi C, Di Domenico F.
Int J Mol Sci. 2021 Apr 3;22(7):3746. doi: 10.3390/ijms22073746.
Importance of amino acids in brain parenchyma invasion by cancer cells
March 2021
Alessio Paone, Amani Bouzidi, Serena Rinaldo, Giorgio Giardina, and Francesca Cutruzzolà
Oncoscience March 31, 2021
DOI: 10.18632/oncoscience.530
Biophysical characterization of melanoma cell phenotype markers during metastatic progression.
Sobiepanek A, Paone A, Cutruzzolà F, Kobiela T.
Eur Biophys J. 2021 Mar 17. doi: 10.1007/s00249-021-01514-8. Online ahead of print.
Studying GGDEF Domain in the Act: Minimize Conformational Frustration to Prevent Artefacts.
Mantoni F, Scribani Rossi C, Paiardini A, Di Matteo A, Cappellacci L, Petrelli R, Ricciutelli M, Paone A, Cutruzzolà F, Giardina G, Rinaldo S.
Life (Basel). 2021 Jan 6;11(1):31. doi: 10.3390/life11010031.
Cytosolic serine hydroxymethyltransferase controls lung adenocarcinoma cells migratory ability by modulating AMP kinase activity.
Bouzidi A, Magnifico MC, Paiardini A, Macone A, Boumis G, Giardina G, Rinaldo S, Liberati FR, Lauro C, Limatola C, Lanzillotta C, Tramutola A, Perluigi M, Sgarbi G, Solaini G, Baracca A, Paone A, Cutruzzolà F.
Cell Death Dis. 2020 Nov 26;11(11):1012. doi: 10.1038/s41419-020-03215-0.
Targeting the Interaction between the SH3 Domain of Grb2 and Gab2.
Malagrinò F, Coluccia A, Bufano M, Regina G, Puxeddu M, Toto A, Visconti L, Paone A, Magnifico MC, Troilo F, Cutruzzolà F, Silvestri R, Gianni S.
Cells. 2020 Nov 7;9(11):2435. doi: 10.3390/cells9112435.
Fractalkine Modulates Microglia Metabolism in Brain Ischemia.
Lauro C, Chece G, Monaco L, Antonangeli F, Peruzzi G, Rinaldo S, Paone A, Cutruzzolà F, Limatola C.
Front Cell Neurosci. 2019 Sep 13;13:414. doi: 10.3389/fncel.2019.00414. eCollection 2019.
Linking Infection and Prostate Cancer Progression: Toll-like Receptor3 Stimulation Rewires Glucose Metabolism in Prostate Cells.
Magnifico MC, Macone A, Marani M, Bouzidi A, Giardina G, Rinaldo S, Cutruzzolà F, Paone A.
Anticancer Res. 2019 Oct;39(10):5541-5549. doi: 10.21873/anticanres.13747.

Fractalkine Modulates Microglia Metabolism in Brain Ischemia
Clotilde Lauro, Giuseppina Chece, Lucia Monaco, Fabrizio Antonangeli, Giovanna Peruzzi, Serena Rinaldo, Alessio Paone, Francesca Cutruzzolà and Cristina Limatola
Front. Cell. Neurosci., 13 September 2019 | https://doi.org/10.3389/fncel.2019.00414
The moonlighting RNA-binding activity of cytosolic serine hydroxymethyltransferase contributes to control compartmentalization of serine metabolism.
Guiducci G*, Paone A*, Tramonti A, Giardina G, Rinaldo S, Bouzidi A, Magnifico MC, Marani M, Menendez JA, Fatica A, Macone A, Armaos A, Tartaglia GG, Contestabile R, Paiardini A, Cutruzzolà F.
Nucleic Acids Res. 2019 Feb 27. pii: gkz129. doi: 10.1093/nar/gkz129. [Epub ahead of print]
Insights into the GTP-dependent allosteric control of c-di-GMP hydrolysis from the crystal structure of PA0575 protein from Pseudomonas aeruginosa.
Mantoni F, Paiardini A, Brunotti P, D'Angelo C, Cervoni L, Paone A, Cappellacci L, Petrelli R, Ricciutelli M, Leoni L, Rampioni G, Arcovito A, Rinaldo S, Cutruzzolà F, Giardina G.
FEBS J. 2018 Oct;285(20):3815-3834. doi: 10.1111/febs.14634. Epub 2018 Sep 7.

A novel bacterial l-arginine sensor controlling c-di-GMP levels in Pseudomonas aeruginosa.
Paiardini A, Mantoni F, Giardina G, Paone A, Janson G, Leoni L, Rampioni G, Cutruzzolà F, Rinaldo S.
Proteins. 2018 Oct;86(10):1088-1096. doi: 10.1002/prot.25587. Epub 2018 Sep 8.
The catalytic activity of serine hydroxymethyltransferase is essential for de novo nuclear dTMP synthesis in lung cancer cells.
Giardina G*, Paone A*, Tramonti A, Lucchi R, Marani M, Magnifico MC, Bouzidi A, Pontecorvi V, Guiducci G, Zamparelli C, Rinaldo S, Paiardini A, Contestabile R, Cutruzzolà F.
FEBS J. 2018 Sep;285(17):3238-3253. doi: 10.1111/febs.14610. Epub 2018 Aug 7.
Differential inhibitory effect of a pyrazolopyran compound on human serine hydroxymethyltransferase-amino acid complexes.
Tramonti A, Paiardini A, Paone A, Bouzidi A, Giardina G, Guiducci G, Magnifico MC, Rinaldo S, McDermott L, Menendez JA, Contestabile R, Cutruzzolà F.
Arch Biochem Biophys. 2018 Sep 1;653:71-79. doi: 10.1016/j.abb.2018.07.001. Epub 2018 Jul 4.


Beyond nitrogen metabolism: nitric oxide, cyclic-di-GMP and bacterial biofilms.
Rinaldo S, Giardina G, Mantoni F, Paone A, Cutruzzolà F.
FEMS Microbiol Lett. 2018 Mar 1;365(6). doi: 10.1093/femsle/fny029.
Discovering Selective Diguanylate Cyclase Inhibitors: From PleD to Discrimination of the Active Site of Cyclic-di-GMP Phosphodiesterases.
Rinaldo S, Giardina G, Mantoni F, Paiardini A, Paone A, Cutruzzolà F.
Methods Mol Biol. 2017;1657:431-453. doi: 10.1007/978-1-4939-7240-1_32.
Glucose Metabolism in the Progression of Prostate Cancer.
Cutruzzolà F, Giardina G, Marani M, Macone A, Paiardini A, Rinaldo S, Paone A.
Front Physiol. 2017 Feb 21;8:97. doi: 10.3389/fphys.2017.00097. eCollection 2017. Review.PMID: 28270771
A pyrazolopyran derivative preferentially inhibits the activity of human cytosolic serine hydroxymethyltransferase and induces cell death in lung cancer cells.
Marani M*, Paone A*, Fiascarelli A, Macone A, Gargano M, Rinaldo S, Giardina G, Pontecorvi V, Koes D, McDermott L, Yang T, Paiardini A, Contestabile R, Cutruzzolà F.
Oncotarget. 2016 Jan 26;7(4):4570-83. doi: 10.18632/oncotarget.6726.
How pyridoxal 5'-phosphate differentially regulates human cytosolic and mitochondrial serine hydroxymethyltransferase oligomeric state.
Giardina G, Brunotti P, Fiascarelli A, Cicalini A, Costa MG, Buckle AM, di Salvo ML, Giorgi A, Marani M, Paone A, Rinaldo S, Paiardini A, Contestabile R, Cutruzzolà F.
FEBS J. 2015 Apr;282(7):1225-41. doi: 10.1111/febs.13211. Epub 2015 Feb 13.
Screening and in vitro testing of antifolate inhibitors of human cytosolic serine hydroxymethyltransferase.
Paiardini A, Fiascarelli A, Rinaldo S, Daidone F, Giardina G, Koes DR, Parroni A, Montini G, Marani M, Paone A, McDermott LA, Contestabile R, Cutruzzolà F.
ChemMedChem. 2015 Mar;10(3):490-7. doi: 10.1002/cmdc.201500028. Epub 2015 Feb 10.
MicroRNA-135b promotes cancer progression by acting as a downstream effector of oncogenic pathways in colon cancer.
Valeri N, Braconi C, Gasparini P, Murgia C, Lampis A, Paulus-Hock V, Hart JR, Ueno L, Grivennikov SI, Lovat F, Paone A, Cascione L, Sumani KM, Veronese A, Fabbri M, Carasi S, Alder H, Lanza G, Gafa' R, Moyer MP, Ridgway RA, Cordero J, Nuovo GJ, Frankel WL, Rugge M, Fassan M, Groden J, Vogt PK, Karin M, Sansom OJ, Croce CM.
Cancer Cell. 2014 Apr 14;25(4):469-83. doi: 10.1016/j.ccr.2014.03.006.
SHMT1 knockdown induces apoptosis in lung cancer cells by causing uracil misincorporation.
Paone A, Marani M, Fiascarelli A, Rinaldo S, Giardina G, Contestabile R, Paiardini A, Cutruzzolà F.
Cell Death Dis. 2014 Nov 20;5:e1525. doi: 10.1038/cddis.2014.482.
Cell death.
Giampietri C, Paone A, D'Alessio A.
Int J Cell Biol. 2014;2014:864062. doi: 10.1155/2014/864062. Epub 2014 May 11
An analysis of genetic factors related to risk of inflammatory bowel disease and colon cancer.
Ryan BM, Wolff RK, Valeri N, Khan M, Robinson D, Paone A, Bowman ED, Lundgreen A, Caan B, Potter J, Brown D, Croce C, Slattery ML, Harris CC.
Cancer Epidemiol. 2014 Oct;38(5):583-90. doi: 10.1016/j.canep.2014.07.003. Epub 2014 Aug 15.
Toll-like receptor 3 (TLR3) activation induces microRNA-dependent reexpression of functional RARβ and tumor regression.
Galli R*, Paone A*, Fabbri M, Zanesi N, Calore F, Cascione L, Acunzo M, Stoppacciaro A, Tubaro A, Lovat F, Gasparini P, Fadda P, Alder H, Volinia S, Filippini A, Ziparo E, Riccioli A, Croce CM.
Proc Natl Acad Sci U S A. 2013 Jun 11;110(24):9812-7. doi: 10.1073/pnas.1304610110. Epub 2013 May 28.
A new role for microRNAs, as ligands of Toll-like receptors
Muller Fabbri, Alessio Paone, Federica Calore, Roberta Galli and Carlo M. Croce
RNA Biology Volume 10, Issue 2 2013 Feb

miR-EdiTar: A database of predicted A-to-I edited miRNA target sites
Alessandro Laganà, Alessio Paone, Dario Veneziano, Luciano Cascione,
Pierluigi Gasparini, Stefania Carasi, Francesco Russo, Giovanni Nigita, Valentina Macca, Rosalba Giugno, Alfredo Pulvirenti, Dennis Shasha, Alfredo Ferro and Carlo M. Croce1
Bioinformatics. 2012 Oct 7 [Epub ahead of print] PMID:23044546
MicroRNAs bind to Toll-like receptors to induce prometastatic inflammatory response.
Fabbri M, Paone A, Calore F, Galli R, Gaudio E, Santhanam R, Lovat F, Fadda P, Mao C, Nuovo GJ, Zanesi N, Crawford M, Ozer GH, Wernicke D, Alder H, Caligiuri MA, Nana-Sinkam P, Perrotti D, Croce CM.
Proc Natl Acad Sci U S A. 2012 Jul 31;109(31):E2110-6. Epub 2012 Jul 2.

Press release
Cancer. Malicious exosomes.Anastasiadou E, Slack FJ.
Science. 2014 Dec 19;346(6216):1459-60. doi: 10.1126/science.aaa4024. No abstract available.
rs4919510 in hsa-mir-608 Is Associated with Outcome but Not Risk of Colorectal Cancer.
Ryan BM, McClary AC, Valeri N, Robinson D, Paone A, Bowman ED, Robles AI, Croce C, Harris CC.
PLoS One. 2012;7(5):e36306. Epub 2012 May 11.
MicroRNAs as New Characters in the Plot between Epigenetics and Prostate Cancer.
Paone A, Galli R, Fabbri M.
Front Genet. 2011;2:62. Epub 2011 Sep 6.PMID: 22303357
MicroRNA-21 induces resistance to 5-fluorouracil by down-regulating human DNA MutS homolog 2 (hMSH2).
Valeri N, Gasparini P, Braconi C, Paone A, Lovat F, Fabbri M, Sumani KM, Alder H, Amadori D, Patel T, Nuovo GJ, Fishel R, Croce CM.
Proc Natl Acad Sci U S A. 2010 Dec 7;107(49):21098-103. Epub 2010 Nov 15.
TLR stimulation of prostate tumor cells induces chemokine-mediated recruitment of specific immune cell types.
Galli R, Starace D, Busà R, Angelini DF, Paone A, De Cesaris P, Filippini A, Sette C, Battistini L, Ziparo E,
Riccioli A.
J Immunol. 2010 Jun 15;184(12):6658-69. Epub 2010 May 17

Toll-like receptor 3 regulates angiogenesis and apoptosis in prostate cancer cell lines through hypoxia-inducible factor 1 alpha.
Paone A, Galli R, Gabellini C, Lukashev D, Starace D, Gorlach A, De Cesaris P, Ziparo E, Del Bufalo D, Sitkovsky MV, Filippini A, Riccioli A.
Neoplasia. 2010 Jul;12(7):539-49
Toll-like receptor 3 activation induces antiviral immune responses in mouse sertoli cells.
Starace D, Galli R, Paone A, De Cesaris P, Filippini A, Ziparo E, Riccioli A.
Biol Reprod. 2008 Oct;79(4):766-75. Epub 2008 Jul 2.
Toll-like receptor 3 triggers apoptosis of human prostate cancer cells through a PKC-alpha-dependent mechanism.
Paone A, Starace D, Galli R, Padula F, De Cesaris P, Filippini A, Ziparo E, Riccioli A.
Carcinogenesis. 2008 Jul;29(7):1334-42. Epub 2008 Jun 19.
c-Flip(L) is expressed in undifferentiated mouse male germ cells.
Giampietri C, Petrungaro S, Coluccia P, Antonangeli F, Paone A, Padula F, De Cesaris P, Ziparo E, Filippini A.
FEBS Lett. 2006 Nov 13;580(26):6109-14. Epub 2006 Oct 16.
c-Flip expression and function in fetal mouse gonocytes.
Giampietri C, Petrungaro S, Klinger FG, Coluccia P, Paone A, Vivarelli E, Filippini A, De Cesaris P, De Felici M,
Ziparo E.
FASEB J. 2006 Jan;20(1):124-6. Epub 2005 Nov 1.



Part XIII – Conferences


Participation in national and international meetings, including 3 oral, 6 poster presentations as selected abstract and 1 best poster price

Year Title notes
2008 Toll Like Receptor activation induces cytokine upregulation in human prostate cancer cells
Paone A., Starace D., Galli R., Padula F., De Cesaris P., Filippini A., Ziparo E. and Riccioli A.
“Cytokines 2008” Florence Italy, December 2-6, 2008 poster
2009 HIF-1a activation by Toll Like Receptor-3 agonist poly (I:C) in prostate cancer cell line
Paone A.*, Galli R., Starace D., De Cesaris P., Filippini A., Ziparo E. and Riccioli A.
“Inflammation and Cancer” Berlin, Germany, September 24 – 25, 2009 poster
2010 mir-21 causes resistance to 5-fluorouracil by inducing MSH2-MSH6 downregulation in colon cancer.
Nicola Valeri, Pierluigi Gasparini, Chiara Braconi, Francesca Lovat, Alessio Paone, Muller Fabbri, Gerard Nuovo, Carlo Croce.
“Colorectal Cancer: Biology to Therapy” Philadelphia (PA) USA, October 27-30, 2010 poster
2015 Probing the metabolic reprogramming of cancer cells: functional and struttural studies of human serine hydrximethyltransferase
Paone Alessio, Giorgio Giardina, Paolo Brunotti, Marina Marani, Serena Rinaldo, Alessandro Paiardini, Roberto Contastabile Francesca Cutruzzolà.
Cancer and Metabolism conference 2015:
September 28-30, 2015
Robinson College, Cambridge UK poster
2016 A pyrazolopyran derivative preferentially inhibits the activity of human cytosolic serine hydroxymethyltransferase and induces cell death in lung cancer cells
Marina Marani1, Alessio Paone, Alessio Fiascarelli1, Alberto Macone1, Maurizio Gargano1, Serena Rinaldo1, Giorgio Giardina1, Valentino Pontecorvi1, David Koes2, Lee McDermott3, Tianyi Yang 4, Alessandro Paiardini5, Roberto Contestabile1, Francesca Cutruzzolà1
SIC VERONA. SEPTEMBER 5-8. 2016
poster
2016 FISV 2016 September 22 2016 Rome, Italy
TOLL LIKE RECEPTORS:
linking inflammation to carcinogenesis Abstract selected for the Oral presentation
2018 Metabolic Regulation of The Immune Response
8th June 2018 | Rome
Aula Convegni CNR
Linking inflammation to prostate cancer: innate immune receptor stimulation triggers metabolic re-programming in non-immune cells. Abstract selected for the Oral presentation
2018 The druggable proteome in cancer Molecular approaches to ameliorate the diagnostic, prognostic and therapeutic indexes in cancer
26th June 2018 Rome
Università Cattolica del Sacro Cuore, Largo Francesco Vito 1
Serine Hydroxymethyltransferase, a key metabolic target in cancer chemotherapy Abstract selected for the Oral presentation
2021 SIBBM 2021 • Frontiers in Molecular Biology
Online • 7-10 June 2021
Riboregulation of human serine hydroxymethyltransferase
enzyme activity reveals a novel strategy to shape cell metabolism Best poster price
2021 61° SIB meeting 2021
Online • 23-24 September 2021
Riboregulation of human serine hydroxymethyltransferase
enzyme activity reveals a novel strategy to shape cell metabolism Invited speaker
2022 Defining and defeating metastasis
19 - 22 Jun 2022 Heidelberg
Amino acid metabolism supports cancer cells extravasation and metastasis formation in the brain Poster


I, the undersigned Alessio Paone
Place of birth Formia
Date of birth 25/01/1980 Nationality ITALIAN
alessio.paone@pec.it
aware of the consequences of making false statements, falsehood of acts and use of false facts,
punishable by law according to art. 76 D.P.R. n. 445/2000 and art. 496 of the Italian Penal Code, under my own responsibility