11573/1701222 - 2024 -
SIRT3 Activation a Promise in Drug Development? New Insights into SIRT3 Biology and Its Implications on the Drug Discovery Process Lambona, Chiara; Zwergel, Clemens; Valente, Sergio; Mai, Antonello - 01g Articolo di rassegna (Review)
rivista: JOURNAL OF MEDICINAL CHEMISTRY (Washington, DC: American Chemical Society) pp. 1662-1689 - issn: 0022-2623 - wos: (0) - scopus: 2-s2.0-85183983381 (0)
11573/1700487 - 2024 -
HDAC1/2 control mesothelium/ovarian cancer adhesive interactions impacting on Talin-1-α5β1-integrin-mediated actin cytoskeleton and extracellular matrix protein remodeling Terri, Michela; Sandoval, Pilar; Bontempi, Giulio; Montaldo, Claudia; Tomero-Sanz, Henar; De Turris, Valeria; Trionfetti, Flavia; Pascual-Antón, Lucía; Clares-Pedrero, Irene; Battistelli, Cecilia; Valente, Sergio; Zwergel, Clemens; Mai, Antonello; Rosanò, Laura; Del Pozo, Miguel Ángel; Sánchez-Álvarez, Miguel; Cabañas, Carlos; Tripodi, Marco; López-Cabrera, Manuel; Strippoli, Raffaele - 01a Articolo in rivista
rivista: JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH (London : BioMed Central) pp. - - issn: 1756-9966 - wos: (0) - scopus: (0)
11573/1702828 - 2024 -
Mechanisms of mesothelial cell response to viral infections: HDAC1-3 inhibition blocks poly(I:C)-induced type I interferon response and modulates the mesenchymal/inflammatory phenotype Trionfetti, Flavia; Montaldo, Claudia; Caiello, Ivan; Bontempi, Giulio; Terri, Michela; Tiberi, Marta; Marchant, Vanessa; Domenici, Alessandro; Menè, Paolo; Cordani, Marco; Zwergel, Clemens; Prencipe, Giusi; Ruiz-Ortega, Marta; Valente, Sergio; Mai, Antonello; Tripodi, Marco; Strippoli, Raffaele - 01a Articolo in rivista
rivista: FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY (Lausanne : Frontiers Media SA, 2011-) pp. - - issn: 2235-2988 - wos: (0) - scopus: (0)
11573/1705172 - 2024 -
Theileria parasites sequester host eIF5A to escape elimination by host-mediated autophagy Villares, Marie; Lourenço, Nelly; Ktorza, Ivan; Berthelet, Jérémy; Panagiotou, Aristeidis; Richard, Aurélie; Amo, Angélique; Koziy, Yulianna; Medjkane, Souhila; Valente, Sergio; Fioravanti, Rossella; Pioche-Durieu, Catherine; Lignière, Laurent; Chevreux, Guillaume; Mai, Antonello; Weitzman, Jonathan B. - 01a Articolo in rivista
rivista: NATURE COMMUNICATIONS (London: Nature Publishing Group-Springer Nature) pp. - - issn: 2041-1723 - wos: (0) - scopus: (0)
11573/1673946 - 2023 -
Role of SIRT3 in Microgravity Response: A New Player in Muscle Tissue Recovery Aventaggiato, Michele; Barreca, Federica; Vitiello, Laura; Vespa, Simone; Valente, Sergio; Rotili, Dante; Mai, Antonello; Lotti, Lavinia Vittoria; Sansone, Luigi; Russo, Matteo A.; Bizzarri, Mariano; Ferretti, Elisabetta; Tafani, Marco - 01a Articolo in rivista
rivista: CELLS (Basel: mdpi-Molecular Diversity Preservation International) pp. - - issn: 2073-4409 - wos: WOS:000947513100001 (2) - scopus: 2-s2.0-85149752388 (2)
11573/1687782 - 2023 -
SIRT5 Activation and Inorganic Phosphate Binding Reduce Cancer Cell Vitality by Modulating Autophagy/Mitophagy and ROS Barreca, Federica; Aventaggiato, Michele; Vitiello, Laura; Sansone, Luigi; Russo, Matteo Antonio; Mai, Antonello; Valente, Sergio; Tafani, Marco - 01a Articolo in rivista
rivista: ANTIOXIDANTS (Basel: MDPI) pp. 1635- - issn: 2076-3921 - wos: WOS:001119091200001 (2) - scopus: 2-s2.0-85169132437 (3)
11573/1694442 - 2023 -
Hydroxamate-based compounds are potent inhibitors of Toxoplasma gondii HDAC biological activity Boissavy, Tom; Rotili, Dante; Mouveaux, Thomas; Roger, Emmanuel; Aliouat, El Moukthar; Pierrot, Christine; Valente, Sergio; Mai, Antonello; Gissot, Mathieu - 01a Articolo in rivista
rivista: ANTIMICROBIAL AGENTS AND CHEMOTHERAPY (American Society for Microbiology:PO Box 11127:Birmingham, AL 35201:(800)633-4931, (205)995-1567, EMAIL: asm.nonmembers.subs@ebsco.com, INTERNET: http://www.asm.org, Fax: (205)995-1588) pp. e0066123- - issn: 0066-4804 - wos: WOS:001090003100001 (0) - scopus: (0)
11573/1674091 - 2023 -
GreenMedChem- the challenge in the next decade toward eco-friendly compounds and processes in drug design Castiello, Carola; Junghanns, Pierre; Mergel, Annika; Jacob, Claus; Ducho, Christian; Valente, Sergio; Rotili, Dante; Fioravanti, Rossella; Zwergel, Clemens; Mai, Antonello - 01g Articolo di rassegna (Review)
rivista: GREEN CHEMISTRY (Royal Society of Chemistry:Thomas Graham House, Science Park, Cambridge CB4 0WF United Kingdom:011 44 1223 432360, EMAIL: sales@rsc.org, INTERNET: http://www.rsc.org, http://www.chensoc.org, Fax: 011 44 1223 423429) pp. 2109-2169 - issn: 1463-9262 - wos: WOS:000946579600001 (5) - scopus: 2-s2.0-85150432512 (10)
11573/1662777 - 2023 -
Novel pyridine-containing histone deacetylase inhibitors strongly arrest proliferation, induce apoptosis and modulate miRNAs in cancer cells Di Bello, Elisabetta; Sian, Veronica; Bontempi, Giulio; Zwergel, Clemens; Fioravanti, Rossella; Noce, Beatrice; Castiello, Carola; Tomassi, Stefano; Corinti, Davide; Passeri, Daniela; Pellicciari, Roberto; Mercurio, Ciro; Varasi, Mario; Altucci, Lucia; Tripodi, Marco; Strippoli, Raffaele; Nebbioso, Angela; Valente, Sergio; Mai, Antonello - 01a Articolo in rivista
rivista: EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY (Editions Scientifique & Medical Elsevier:23 Rue Linois, F 75724 Paris Cedex 15 France:011 33 1 71724646, INTERNET: http://www.elsevier.fr, Fax: 011 33 1 71724664) pp. 115022- - issn: 0223-5234 - wos: WOS:000911596400001 (2) - scopus: 2-s2.0-85144323384 (3)
11573/1669899 - 2023 -
METTL3 from Target Validation to the First Small-Molecule Inhibitors: A Medicinal Chemistry Journey Fiorentino, Francesco; Menna, Martina; Rotili, Dante; Valente, Sergio; Mai, Antonello - 01g Articolo di rassegna (Review)
rivista: JOURNAL OF MEDICINAL CHEMISTRY (Washington DC : ACS Publications) pp. 1654-1677 - issn: 1520-4804 - wos: WOS:000932489700001 (10) - scopus: 2-s2.0-85147012551 (11)
11573/1685964 - 2023 -
Histone deacetylase 10: A polyamine deacetylase from the crystal structure to the first inhibitors Lambona, Chiara; Zwergel, Clemens; Fioravanti, Rossella; Valente, Sergio; Mai, Antonello - 01g Articolo di rassegna (Review)
rivista: CURRENT OPINION IN STRUCTURAL BIOLOGY (Current Biology Limited:84 Theobalds Road, London WC1X 8RR United Kingdom:011 44 20 76114202, EMAIL: info@biomednet.com, INTERNET: http://www.biomednet.com, Fax: 011 44 20 76114479) pp. - - issn: 0959-440X - wos: (0) - scopus: 2-s2.0-85166517965 (1)
11573/1658358 - 2023 -
Chemically diverse S. mansoni HDAC8 inhibitors reduced viability in worm larval and adult stages Noce, Beatrice; Di Bello, Elisabetta; Zwergel, Clemens; Fioravanti, Rossella; Valente, Sergio; Rotili, Dante; Masotti, Andrea; Ansari, Mohammad Salik Zeya; Trisciuoglio, Daniela; Chakrabarti, Alokta; Romier, Christophe; Robaa, Dina; Sippl, Wolfgang; Jung, Manfred; Häberli, Cécile; Keiser, Jennifer; Mai, Antonello - 01a Articolo in rivista
rivista: CHEMMEDCHEM (Weinheim : Wiley-VCH-Verl..) pp. - - issn: 1860-7179 - wos: WOS:000879912800001 (2) - scopus: 2-s2.0-85141693563 (2)
11573/1691312 - 2023 -
Targeting ROS production through inhibition of NADPH oxidases Reis, Joana; Gorgulla, Christoph; Massari, Marta; Marchese, Sara; Valente, Sergio; Noce, Beatrice; Basile, Lorenzo; Törner, Ricarda; Cox, Huel; Viennet, Thibault; Yang, Moon Hee; Ronan, Melissa M; Rees, Matthew G; Roth, Jennifer A; Capasso, Lucia; Nebbioso, Angela; Altucci, Lucia; Mai, Antonello; Arthanari, Haribabu; Mattevi, Andrea - 01a Articolo in rivista
rivista: NATURE CHEMICAL BIOLOGY (New York, N.Y. : Nature Pub. Group, 2005-) pp. 1540-1550 - issn: 1552-4469 - wos: WOS:001090044900002 (1) - scopus: 2-s2.0-85174921719 (1)
11573/1696065 - 2023 -
HDAC1-3 inhibition increases SARS-CoV-2 replication and productive infection in lung mesothelial and epithelial cells Trionfetti, Flavia; Alonzi, Tonino; Bontempi, Giulio; Terri, Michela; Battistelli, Cecilia; Montaldo, Claudia; Repele, Federica; Rotili, Dante; Valente, Sergio; Zwergel, Clemens; Matusali, Giulia; Maggi, Fabrizio; Goletti, Delia; Tripodi, Marco; Mai, Antonello; Strippoli, Raffaele - 01a Articolo in rivista
rivista: FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY (Lausanne : Frontiers Media SA, 2011-) pp. - - issn: 2235-2988 - wos: WOS:001130489700001 (1) - scopus: (0)
11573/1684985 - 2023 -
Novel 1,4-Dihydropyridines as Specific Binders and Activators of SIRT3 Impair Cell Viability and Clonogenicity and Downregulate Hypoxia-Induced Targets in Cancer Cells Zwergel, Clemens; Aventaggiato, Michele; Garbo, Sabrina; Di Bello, Elisabetta; Fassari, Bruno; Noce, Beatrice; Castiello, Carola; Lambona, Chiara; Barreca, Federica; Rotili, Dante; Fioravanti, Rossella; Schmalz, Thomas; Weyand, Michael; Niedermeier, Amelie; Tripodi, Marco; Colotti, Gianni; Steegborn, Clemens; Battistelli, Cecilia; Tafani, Marco; Valente, Sergio; Mai, Antonello - 01a Articolo in rivista
rivista: JOURNAL OF MEDICINAL CHEMISTRY (Washington, DC: American Chemical Society) pp. 9622-9641 - issn: 0022-2623 - wos: WOS:001027732800001 (1) - scopus: 2-s2.0-85165671509 (3)
11573/1659806 - 2022 -
Restoration of WT1/miR-769-5p axis by HDAC1 inhibition promotes MMT reversal in mesenchymal-like mesothelial cells Bontempi, Giulio; Terri, Michela; Garbo, Sabrina; Montaldo, Claudia; Mariotti, Davide; Bordoni, Veronica; Valente, Sergio; Zwergel, Clemens; Mai, Antonello; Marchetti, Alessandra; Domenici, Alessandro; Menè, Paolo; Battistelli, Cecilia; Tripodi, Marco; Strippoli, Raffaele - 01a Articolo in rivista
rivista: CELL DEATH & DISEASE (Nature Group) pp. 965- - issn: 2041-4889 - wos: WOS:000885083500004 (6) - scopus: 2-s2.0-85142134241 (7)
11573/1643002 - 2022 -
Determinants of epigenetic resistance to HDAC inhibitors in dystrophic fibro-adipogenic progenitors Consalvi, S.; Tucciarone, L.; Macri, E.; De Bardi, M.; Picozza, M.; Salvatori, I.; Renzini, A.; Valente, S.; Mai, A.; Moresi, V.; Puri, P. L. - 01a Articolo in rivista
rivista: EMBO REPORTS (Oxford : Oxford University Press, 2000-) pp. 1-19 - issn: 1469-221X - wos: WOS:000778177100001 (3) - scopus: 2-s2.0-85127391022 (5)
11573/1705179 - 2022 -
Novel Targeting of DNA Methyltransferase Activity Inhibits Ewing Sarcoma Cell Proliferation and Enhances Tumor Cell Sensitivity to DNA Damaging Drugs by Activating the DNA Damage Response Cristalli, C.; Manara, M. C.; Valente, S.; Pellegrini, E.; Bavelloni, A.; De Feo, A.; Blalock, W.; Di Bello, E.; Pineyro, D.; Merkel, A.; Esteller, M.; Tirado, O. M.; Mai, A.; Scotlandi, K. - 01a Articolo in rivista
rivista: FRONTIERS IN ENDOCRINOLOGY (Lausanne : Frontiers Research Foundation, 2010-) pp. - - issn: 1664-2392 - wos: (0) - scopus: 2-s2.0-85132379050 (4)
11573/1650772 - 2022 -
Effects of Structurally Different HDAC Inhibitors against Trypanosoma cruzi, Leishmania, and Schistosoma mansoni Di Bello, Elisabetta; Noce, Beatrice; Fioravanti, Rossella; Zwergel, Clemens; Valente, Sergio; Rotili, Dante; Fianco, Giulia; Trisciuoglio, Daniela; Mourão, Marina M; Sales, Policarpo; Lamotte, Suzanne; Prina, Eric; Späth, Gerald F; Häberli, Cécile; Keiser, Jennifer; Mai, Antonello - 01a Articolo in rivista
rivista: ACS INFECTIOUS DISEASES (Washington, DC : American Chemical Society, 2015-) pp. 1356-1366-1366 - issn: 2373-8227 - wos: WOS:000819851400001 (11) - scopus: 2-s2.0-85134360722 (11)
11573/1623778 - 2022 -
Heterocycle-containing tranylcypromine derivatives endowed with high anti-LSD1 activity Fioravanti, Rossella; Rodriguez, Veronica; Caroli, Jonatan; Chianese, Ugo; Benedetti, Rosaria; Di Bello, Elisabetta; Noce, Beatrice; Zwergel, Clemens; Corinti, Davide; Viña, Dolores; Altucci, Lucia; Mattevi, Andrea; Valente, Sergio; Mai, Antonello - 01a Articolo in rivista
rivista: JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY (Taylor & Francis Limited:Rankine Road, Basingstoke RG24 8PR United Kingdom:011 44 1256 813035, EMAIL: madeline.sims@tandf.co.uk, info@tandf.co.uk, INTERNET: http://www.tandf.co.uk, Fax: 011 44 1256 330245) pp. 973-985 - issn: 1475-6366 - wos: WOS:000771778600001 (1) - scopus: 2-s2.0-85126852334 (1)
11573/1612791 - 2022 -
Inhibition of PKCθ Improves Dystrophic Heart Phenotype and Function in a Novel Model of DMD Cardiomyopathy Morroni, Jacopo; Schirone, Leonardo; Valenti, Valentina; Zwergel, Clemens; Riera, Carles Sánchez; Valente, Sergio; Vecchio, Daniele; Schiavon, Sonia; Ragno, Rino; Mai, Antonello; Sciarretta, Sebastiano; Lozanoska-Ochser, Biliana; Bouchè, Marina - 01a Articolo in rivista
rivista: INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (Basel: MDPI Center) pp. 1-16 - issn: 1422-0067 - wos: WOS:000772462700001 (1) - scopus: 2-s2.0-85124895071 (1)
11573/1614439 - 2022 -
Cytoplasmic HDAC4 regulates the membrane repair mechanism in Duchenne muscular dystrophy Renzini, A.; Marroncelli, N.; Cavioli, G.; Di Francescantonio, S.; Forcina, L.; Lambridis, A.; Di Giorgio, E.; Valente, S.; Mai, A.; Brancolini, C.; Giampietri, C.; Magenta, A.; De Santa, F.; Adamo, S.; Coletti, D.; Moresi, V. - 01a Articolo in rivista
rivista: JOURNAL OF CACHEXIA, SARCOPENIA AND MUSCLE (Heidelberg ; Berlin : Springer) pp. 1339-1359 - issn: 2190-5991 - wos: WOS:000755498900001 (9) - scopus: 2-s2.0-85124595217 (9)
11573/1657657 - 2022 -
Potent and Specific Activators for Mitochondrial Sirtuins Sirt3 and Sirt5 Suenkel, Benjamin; Valente, Sergio; Zwergel, Clemens; Weiss, Sandra; Di Bello, Elisabetta; Fioravanti, Rossella; Aventaggiato, Michele; Amorim, João A.; Garg, Neha; Kumar, Surinder; Lombard, David B.; Hu, Tuo; Singh, Pankaj K.; Tafani, Marco; Palmeira, Carlos M.; Sinclair, David; Mai, Antonello; Steegborn, Clemens - 01a Articolo in rivista
rivista: JOURNAL OF MEDICINAL CHEMISTRY (Washington, DC: American Chemical Society) pp. 14015-14031 - issn: 0022-2623 - wos: WOS:000878509000001 (10) - scopus: 2-s2.0-85140303478 (16)
11573/1623442 - 2022 -
Targeting the anti-apoptotic Bcl-2 family proteins: Machine learning virtual screening and biological evaluation of new small molecules Valentini, E.; D'aguanno, S.; Di Martile, M.; Montesano, C.; Ferraresi, V.; Patsilinakos, A.; Sabatino, M.; Antonini, L.; Chiacchiarini, M.; Valente, S.; Mai, A.; Colotti, G.; Ragno, R.; Trisciuoglio, D.; Del Bufalo, D. - 01a Articolo in rivista
rivista: THERANOSTICS (Wyoming, N.S.W. : Ivyspring International Publisher, 2011-) pp. 2427-2444 - issn: 1838-7640 - wos: WOS:000766737800003 (6) - scopus: 2-s2.0-85126080507 (7)
11573/1565876 - 2021 -
Editorial: new approaches to tackle EMT and fibrosis: from epigenetics to nanotechnology Battistelli, Cecilia; Cordani, Marco; Diederich, Marc; Somoza, Álvaro; Valente, Sergio; Strippoli, Raffaele - 01m Editorial/Introduzione in rivista
rivista: FRONTIERS IN PHARMACOLOGY (Lausanne: Frontiers Media S.A., 2010-) pp. - - issn: 1663-9812 - wos: WOS:000686867300001 (0) - scopus: 2-s2.0-85113221898 (0)
11573/1550470 - 2021 -
Structure-Guided Development of Small-Molecule PRC2 Inhibitors Targeting EZH2–EED Interaction Du, Daohai; Xu, Dandan; Zhu, Licheng; Stazi, Giulia; Zwergel, Clemens; Liu, Yanli; Luo, Zhongyuan; Li, Yuanqing; Zhang, Yuanyuan; Zhu, Kongkai; Ding, Yiluan; Liu, Jingqiu; Fan, Shijie; Zhao, Kaiyan; Zhang, Naixia; Kong, Xiangqian; Jiang, Hualiang; Chen, Kaixian; Zhao, Kehao; Valente, Sergio; Min, Jinrong; Duan, Wenhu; Luo, Cheng - 01a Articolo in rivista
rivista: JOURNAL OF MEDICINAL CHEMISTRY (Washington, DC: American Chemical Society) pp. 8194-8207 - issn: 0022-2623 - wos: WOS:000668340800017 (18) - scopus: 2-s2.0-85108541842 (23)
11573/1611281 - 2021 -
Metabolic rewiring by loss of sirt5 promotes kras-induced pancreatic cancer progression Hu, T.; Shukla, S. K.; Vernucci, E.; He, C.; Wang, D.; King, R. J.; Jha, K.; Siddhanta, K.; Mullen, N. J.; Attri, K. S.; Murthy, D.; Chaika, N. V.; Thakur, R.; Mulder, S. E.; Pacheco, C. G.; Fu, X.; High, R. R.; Yu, F.; Lazenby, A.; Steegborn, C.; Lan, P.; Mehla, K.; Rotili, D.; Chaudhary, S.; Valente, S.; Tafani, M.; Mai, A.; Auwerx, J.; Verdin, E.; Tuveson, D.; Singh, P. K. - 01a Articolo in rivista
rivista: GASTROENTEROLOGY (USA: Elsevier
Philadelphia, PA: W B Saunders Company) pp. 1584-1600 - issn: 0016-5085 - wos: WOS:000711484200002 (39) - scopus: 2-s2.0-85115084196 (42)
11573/1564224 - 2021 -
Histone-deacetylase 8 drives the immune response and the growth of glioma Mormino, Alessandro; Cocozza, Germana; Fontemaggi, Giulia; Valente, Sergio; Esposito, Vincenzo; Santoro, Antonio; Bernardini, Giovanni; Santoni, Angela; Fazi, Francesco; Mai, Antonello; Limatola, Cristina; Garofalo, Stefano - 01a Articolo in rivista
rivista: GLIA (John Wiley & Sons Incorporated:Customer Service, 111 River Street:Hoboken, NJ 07030:(800)225-5945, (201)748-6000, EMAIL: societyinfo@wiley.com, INTERNET: http://www.wiley.com, Fax: (212)748-6551) pp. 1-17 - issn: 0894-1491 - wos: WOS:000678875900001 (12) - scopus: 2-s2.0-85111697220 (12)
11573/1613681 - 2021 -
Editorial: Natural Product Epigenetic Modulators and Inhibitors Ntie-Kang, Fidele; Karaman Mayack, Berin; Valente, Sergio; Battistelli, Cecilia - 01m Editorial/Introduzione in rivista
rivista: FRONTIERS IN PHARMACOLOGY (Lausanne: Frontiers Media S.A., 2010-) pp. - - issn: 1663-9812 - wos: WOS:000629965700001 (2) - scopus: 2-s2.0-85102865581 (3)
11573/1564901 - 2021 -
Polycomb repressive complex 2 modulation through the development of EZH2–EED interaction inhibitors and EED binders Tomassi, Stefano; Romanelli, Annalisa; Zwergel, Clemens; Valente, Sergio; Mai, Antonello - 01g Articolo di rassegna (Review)
rivista: JOURNAL OF MEDICINAL CHEMISTRY (Washington, DC: American Chemical Society) pp. 11774-11797 - issn: 0022-2623 - wos: WOS:000692012400002 (19) - scopus: 2-s2.0-85114048578 (22)
11573/1467228 - 2021 -
Novel Pyridine-Based Hydroxamates and 2'-Aminoanilides as Histone Deacetylase Inhibitors: Biochemical Profile and Anticancer Activity Zwergel, Clemens; Di Bello, Elisabetta; Fioravanti, Rossella; Conte, Mariarosaria; Nebbioso, Angela; Mazzone, Roberta; Brosch, Gerald; Mercurio, Ciro; Varasi, Mario; Altucci, Lucia; Valente, Sergio; Mai, Antonello - 01a Articolo in rivista
rivista: CHEMMEDCHEM (Weinheim : Wiley-VCH-Verl..) pp. 989-999 - issn: 1860-7179 - wos: WOS:000599084500001 (8) - scopus: 2-s2.0-85097525146 (8)
11573/1361035 - 2020 -
Molecular mechanisms and new therapeutic targets in epithelial to mesenchymal transition (EMT) and fibrosis Battistelli, Cecilia; Diederich, Marc; Keane, Tj; Sandoval, Pilar; Valente, Sergio; Strippoli, Raffaele - 01m Editorial/Introduzione in rivista
rivista: FRONTIERS IN PHARMACOLOGY (Lausanne: Frontiers Media S.A., 2010-) pp. - - issn: 1663-9812 - wos: WOS:000510209700001 (1) - scopus: 2-s2.0-85078745922 (2)
11573/1414757 - 2020 -
Discovery of the first human arylsulfatase a reversible inhibitor impairing mouse oocyte fertilization Caroselli, Silvia; Zwergel, Clemens; Pirolli, Adele; Sabatino, Manuela; Xu, Zhanjie; Kirsch, Gilbert; Mai, Antonello; Colotti, Gianni; Altieri, Fabio; Canipari, Rita; Valente, Sergio; Ragno, Rino - 01a Articolo in rivista
rivista: ACS CHEMICAL BIOLOGY (AMERICAN CHEMICAL SOCiety, 1155 16TH ST, NW, WASHINGTON, USA, DC, 20036) pp. 1349-1357 - issn: 1554-8929 - wos: WOS:000543662300010 (4) - scopus: 2-s2.0-85086748074 (4)
11573/1434640 - 2020 -
CDK9 as a valuable target in cancer: from natural compounds inhibitors to current treatment in pediatric soft tissue sarcomas Cassandri, Matteo; Fioravanti, Rossella; Pomella, Silvia; Valente, Sergio; Rotili, Dante; Del Baldo, Giada; De Angelis, Biagio; Rota, Rossella; Mai, Antonello - 01a Articolo in rivista
rivista: FRONTIERS IN PHARMACOLOGY (Lausanne: Frontiers Media S.A., 2010-) pp. - - issn: 1663-9812 - wos: WOS:000565986100001 (18) - scopus: 2-s2.0-85089884656 (21)
11573/1418417 - 2020 -
The innovative potential of statins in cancer: new targets for new therapies Di Bello, Elisabetta; Zwergel, Clemens; Mai, Antonello; Valente, Sergio - 01g Articolo di rassegna (Review)
rivista: FRONTIERS IN CHEMISTRY (Lausanne : Frontiers Media S.A., 2013-) pp. - - issn: 2296-2646 - wos: WOS:000546786300001 (60) - scopus: 2-s2.0-85087290374 (69)
11573/1382315 - 2020 -
Tranylcypromine-based LSD1 inhibitors: structure-activity relationships, antiproliferative effects in leukemia, and gene target modulation Fioravanti, R.; Romanelli, A.; Mautone, N.; Di Bello, E.; Rovere, A.; Corinti, D.; Zwergel, C.; Valente, S.; Rotili, D.; Botrugno, O. A.; Dessanti, P.; Vultaggio, S.; Vianello, P.; Cappa, A.; Binda, C.; Mattevi, A.; Minucci, S.; Mercurio, C.; Varasi, M.; Mai, A. - 01a Articolo in rivista
rivista: CHEMMEDCHEM (Weinheim : Wiley-VCH-Verl..) pp. 643-658 - issn: 1860-7179 - wos: WOS:000513271600001 (15) - scopus: 2-s2.0-85079446800 (17)
11573/1429805 - 2020 -
Properly substituted cyclic Bis-(2-bromobenzylidene) compounds behaved as dual p300/CARM1 Inhibitors and Induced apoptosis in cancer cells Fioravanti, Rossella; Tomassi, Stefano; Di Bello, Elisabetta; Romanelli, Annalisa; Plateroti, Andrea Maria; Benedetti, Rosaria; Conte, Mariarosaria; Novellino, Ettore; Altucci, Lucia; Valente, Sergio; Mai, Antonello - 01a Articolo in rivista
rivista: MOLECULES (Basel: MDPI
Berlin: Springer, 1996-) pp. - - issn: 1420-3049 - wos: WOS:000558002500001 (2) - scopus: 2-s2.0-85088202424 (3)
11573/1390392 - 2020 -
Altered mitochondrial function in cells carrying a premutation or unmethylated full mutation of the FMR1 gene Nobile, V.; Palumbo, F.; Lanni, S.; Ghisio, V.; Vitali, A.; Castagnola, M.; Marzano, V.; Maulucci, G.; De Angelis, C.; De Spirito, M.; Pacini, L.; D'andrea, L.; Ragno, R.; Stazi, G.; Valente, S.; Mai, A.; Chiurazzi, P.; Genuardi, M.; Neri, G.; Tabolacci, E. - 01a Articolo in rivista
rivista: HUMAN GENETICS (Germany: Springer Verlag Germany) pp. 227-245 - issn: 0340-6717 - wos: WOS:000515839900006 (15) - scopus: 2-s2.0-85077526115 (15)
11573/1390388 - 2020 -
Targeting the scaffolding role of LSD1 (KDM1A) poises acute myeloid leukemia cells for retinoic acid-induced differentiation Ravasio, R.; Ceccacci, E.; Nicosia, L.; Hosseini, A.; Rossi, P. L.; Barozzi, I.; Fornasari, L.; Zuffo, R. D.; Valente, S.; Fioravanti, R.; Mercurio, C.; Varasi, M.; Mattevi, A.; Mai, A.; Pavesi, G.; Bonaldi, T.; Minucci, S. - 01a Articolo in rivista
rivista: SCIENCE ADVANCES (Washington, DC : American Association for the Advancement of Science, 2015-) pp. - - issn: 2375-2548 - wos: WOS:000525751400003 (45) - scopus: 2-s2.0-85083269142 (48)
11573/1390390 - 2020 -
A closer look into NADPH oxidase inhibitors: validation and insight into their mechanism of action Reis, J.; Massari, M.; Marchese, S.; Ceccon, M.; Aalbers, F. S.; Corana, F.; Valente, S.; Mai, A.; Magnani, F.; Mattevi, A. - 01a Articolo in rivista
rivista: REDOX BIOLOGY (Amsterdam : Elsevier) pp. - - issn: 2213-2317 - wos: WOS:000537459900002 (45) - scopus: 2-s2.0-85079650979 (58)
11573/1394955 - 2020 -
Design of first-in-class dual EZH2/HDAC inhibitor: biochemical activity and biological evaluation in cancer cells Romanelli, Annalisa; Stazi, Giulia; Fioravanti, Rossella; Zwergel, Clemens; Di Bello, Elisabetta; Pomella, Silvia; Perrone, Clara; Battistelli, Cecilia; Strippoli, Raffaele; Tripodi, Marco; Del Bufalo, Donatella; Rota, Rossella; Trisciuoglio, Daniela; Mai, Antonello; Valente, Sergio - 01a Articolo in rivista
rivista: ACS MEDICINAL CHEMISTRY LETTERS (USA: ACS Publications) pp. 977-983 - issn: 1948-5875 - wos: WOS:000535281200056 (41) - scopus: 2-s2.0-85087681122 (48)
11573/1364390 - 2020 -
Novel quinoline compounds active in cancer cells through coupled DNA methyltransferase inhibition and degradation Zwergel, C.; Fioravanti, R.; Stazi, G.; Sarno, F.; Battistelli, C.; Romanelli, A.; Nebbioso, A.; Mendes, E.; Paulo, A.; Strippoli, R.; Tripodi, M.; Pechalrieu, D.; Arimondo, P. B.; De Luca, T.; Del Bufalo, D.; Trisciuoglio, D.; Altucci, L.; Valente, S.; Mai, A. - 01a Articolo in rivista
rivista: CANCERS (Basel: MDPI) pp. - - issn: 2072-6694 - wos: WOS:000522477300193 (6) - scopus: 2-s2.0-85079504263 (6)
11573/1193778 - 2019 -
Identification of novel quinazoline derivatives as potent antiplasmodial agents Bouchut, A; Rotili, D; Pierrot, C; Valente, S; Lafitte, S; Schultz, J; Hoglund, U; Mazzone, R; Lucidi, A; Fabrizi, G; Pechalrieu, D; Arimondo, Pb; Skinner-Adams, Ts; Chua, Mj; Andrews, Kt; Mai, A; Khalife, J. - 01a Articolo in rivista
rivista: EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY (Editions Scientifique & Medical Elsevier:23 Rue Linois, F 75724 Paris Cedex 15 France:011 33 1 71724646, INTERNET: http://www.elsevier.fr, Fax: 011 33 1 71724664) pp. 277-291 - issn: 0223-5234 - wos: WOS:000451498200018 (40) - scopus: 2-s2.0-85055197167 (42)
11573/1390394 - 2019 -
The Protein Arginine Methyltransferases 1 and 5 affect Myc properties in glioblastoma stem cells Favia, A.; Salvatori, L.; Nanni, S.; Iwamoto-Stohl, L. K.; Valente, S.; Mai, A.; Scagnoli, F.; Fontanella, R. A.; Totta, P.; Nasi, S.; Illi, B. - 01a Articolo in rivista
rivista: SCIENTIFIC REPORTS (London: Springer Nature
London: Nature Publishing Group) pp. 15925- - issn: 2045-2322 - wos: WOS:000493898100033 (27) - scopus: 2-s2.0-85074323285 (31)
11573/1390399 - 2019 -
Statins and histone deacetylase inhibitors affect lamin A/C - histone deacetylase 2 interaction in human cells Mattioli, Elisabetta; Andrenacci, Davide; Mai, Antonello; Valente, Sergio; Robijns, Joke; De Vos, Winnok H; Capanni, Cristina; Lattanzi, Giovanna - 01a Articolo in rivista
rivista: FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY (Lausanne : Frontiers Media S.A., 2013-) pp. - - issn: 2296-634X - wos: WOS:000467197300001 (16) - scopus: 2-s2.0-85075855435 (13)
11573/1390396 - 2019 -
Histone deacetylases contribute to excitotoxicity-triggered degeneration of retinal ganglion cells in vivo Schluter, A.; Aksan, B.; Fioravanti, R.; Valente, S.; Mai, A.; Mauceri, D. - 01a Articolo in rivista
rivista: MOLECULAR NEUROBIOLOGY (Humana Press Incorporated:999 Riverview Drive, Suite 208:Totowa, NJ 07512:(973)256-1699, EMAIL: lglasner@humanapr.com, INTERNET: http://www.humanapress.com, Fax: (973)256-8341) pp. 8018-8034 - issn: 0893-7648 - wos: WOS:000494860800008 (18) - scopus: 2-s2.0-85067067374 (21)
11573/1339079 - 2019 -
Dissecting the role of novel EZH2 inhibitors in primary glioblastoma cell cultures: effects on proliferation, epithelial-mesenchymal transition, migration, and on the pro-inflammatory phenotype Stazi, G.; Taglieri, L.; Nicolai, Alice; Romanelli, A.; Fioravanti, R.; Morrone, S.; Sabatino, M.; Ragno, R.; Taurone, S.; Nebbioso, M.; Carletti, R.; Artico, M.; Valente, S.; Scarpa, S.; Mai, A. - 01a Articolo in rivista
rivista: CLINICAL EPIGENETICS (Berlin : Springer) pp. 1-17 - issn: 1868-7083 - wos: WOS:000501362500004 (46) - scopus: 2-s2.0-85076062797 (45)
11573/1208206 - 2019 -
Development of alkyl glycerone phosphate synthase inhibitors: Structure-activity relationship and effects on ether lipids and epithelial-mesenchymal transition in cancer cells Stazi, Giulia; Battistelli, Cecilia; Piano, Valentina; Mazzone, Roberta; Marrocco, Biagina; Marchese, Sara; Louie, Sharon M.; Zwergel, Clemens; Antonini, Lorenzo; Patsilinakos, Alexandros; Ragno, Rino; Viviano, Monica; Sbardella, Gianluca; Ciogli, Alessia; Fabrizi, Giancarlo; Cirilli, Roberto; Strippoli, Raffaele; Marchetti, Alessandra; Tripodi, Marco; Nomura, Daniel K.; Mattevi, Andrea; Mai, Antonello; Valente, Sergio - 01a Articolo in rivista
rivista: EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY (Editions Scientifique & Medical Elsevier:23 Rue Linois, F 75724 Paris Cedex 15 France:011 33 1 71724646, INTERNET: http://www.elsevier.fr, Fax: 011 33 1 71724664) pp. 722-735 - issn: 0223-5234 - wos: WOS:000458597300053 (14) - scopus: 2-s2.0-85058530369 (15)
11573/1416968 - 2019 -
Histone deacetylases as an epigenetic pillar for the development of hybrid inhibitors in cancer Stazi, Giulia; Fioravanti, Rossella; Mai, Antonello; Mattevi, Andrea; Valente, Sergio - 01g Articolo di rassegna (Review)
rivista: CURRENT OPINION IN CHEMICAL BIOLOGY (Current Biology Limited:84 Theobalds Road, London WC1X 8RR United Kingdom:011 44 20 76114202, EMAIL: info@biomednet.com, INTERNET: http://www.biomednet.com, Fax: 011 44 20 76114479) pp. 89-100 - issn: 1367-5931 - wos: WOS:000473839100012 (22) - scopus: 2-s2.0-85064167463 (24)
11573/1382317 - 2019 -
Lysine methyltransferases and their inhibitors Stazi, Giulia; Zwergel, Clemens; Valente, Sergio - 02a Capitolo o Articolo
libro: Chemical Epigenetics - (978-3-030-42981-2; 978-3-030-42982-9)
11573/1275490 - 2019 -
Epigenetic Pharmacology in Regenerative Medicine (Epi-Drugs) Stazi, Giulia; Zwergel, Clemens; Valente, Sergio; Mai, Antonello - 02a Capitolo o Articolo
libro: Epigenetics and Regeneration - (9780128148792)
Zwergel, Clemens; Rotili, Dante; Valente, Sergio; Mai, Antonello - 02a Capitolo o Articolo
libro: Epigenetic Drug Discovery - (9783527343140; 9783527809257)
11573/1265927 - 2019 -
Identification of a novel quinoline-based DNA demethylating compound highly potent in cancer cells Zwergel, Clemens; Schnekenburger, Michael; Sarno, Federica; Battistelli, Cecilia; Manara, Maria Cristina; Stazi, Giulia; Mazzone, Roberta; Fioravanti, Rossella; Gros, Christina; Ausseil, Frédéric; Florean, Cristina; Nebbioso, Angela; Strippoli, Raffaele; Ushijima, Toshikazu; Scotlandi, Katia; Tripodi, Marco; Arimondo, Paola B.; Altucci, Lucia; Diederich, Marc; Mai, Antonello; Valente, Sergio - 01a Articolo in rivista
rivista: CLINICAL EPIGENETICS (Berlin : Springer) pp. - - issn: 1868-7083 - wos: WOS:000467227900001 (24) - scopus: 2-s2.0-85065468885 (28)
11573/1147229 - 2018 -
Effects of class II-selective histone deacetylase inhibitor on neuromuscular function and disease progression in SOD1-ALS mice Buonvicino, Daniela; Felici, Roberta; Ranieri, Giuseppe Antonio; Caramelli, Riccardo; Lapucci, Andrea; Cavone, Leonardo; Muzzi, Mirko; Di Pietro, Lorena; Bernardini, Camilla; Zwergel, Clemens; Valente, Sergio; Mai, Antonello; Chiarugi, Alberto - 01a Articolo in rivista
rivista: NEUROSCIENCE (Oxford: Elsevier Ltd.
Oxford; New York: Pergamon Press) pp. 228-238 - issn: 0306-4522 - wos: WOS:000430884100020 (16) - scopus: 2-s2.0-85044974964 (17)
11573/1174048 - 2018 -
Six years (2012-2018) of researches on catalytic EZH2 inhibitors: the boom of the 2-pyridone compounds Fioravanti, R; Stazi, G; Zwergel, C; Valente, S; Mai, A. - 01a Articolo in rivista
rivista: THE CHEMICAL RECORD (New York N.Y.: Wiley, c2000-) pp. 1818-1832 - issn: 1527-8999 - wos: WOS:000453386600014 (69) - scopus: 2-s2.0-85055289007 (74)
11573/1074176 - 2018 -
Targeting the CoREST complex with dual histone deacetylase and demethylase inhibitors Kalin, Jay H.; Wu, Muzhou; Gomez, Andrea V.; Song, Yun; Das, Jayanta; Hayward, Dawn; Adejola, Nkosi; Wu, Mingxuan; Panova, Izabela; Chung, Hye Jin; Kim, Edward; Roberts, Holly J.; Roberts, Justin M.; Prusevich, Polina; Jeliazkov, Jeliazko R.; Roy Burman, Shourya S.; Fairall, Louise; Milano, Charles; Eroglu, Abdulkerim; Proby, Charlotte M.; Dinkova-Kostova, Albena T.; Hancock, Wayne W.; Gray, Jeffrey J.; Bradner, James E.; Valente, Sergio; Mai, Antonello; Anders, Nicole M.; Rudek, Michelle A.; Hu, Yong; Ryu, Byungwoo; Schwabe, John W. R.; Mattevi, Andrea; Alani, Rhoda M.; Cole, Philip A. - 01a Articolo in rivista
rivista: NATURE COMMUNICATIONS (London: Nature Publishing Group-Springer Nature) pp. - - issn: 2041-1723 - wos: WOS:000419404200003 (164) - scopus: 2-s2.0-85040217796 (160)
11573/1147949 - 2018 -
A quinoline-based DNA methyltransferase inhibitor as a possible adjuvant in osteosarcoma therapy Manara, Maria Cristina; Valente, Sergio; Cristalli, Camilla; Nicoletti, Giordano; Landuzzi, Lorena; Zwergel, Clemens; Mazzone, Roberta; Stazi, Giulia; Arimondo, Paola B.; Pasello, Michela; Guerzoni, Clara; Picci, Piero; Nanni, Patrizia; Lollini, Pier-Luigi; Mai, Antonello; Scotlandi, Katia - 01a Articolo in rivista
rivista: MOLECULAR CANCER THERAPEUTICS (Philadelphia, PA : American Association for Cancer Research, c2001-) pp. 1881-1892 - issn: 1535-7163 - wos: WOS:000444041300008 (26) - scopus: 2-s2.0-85053014459 (26)
11573/1147243 - 2018 -
Altered modulation of lamin A/C-HDAC2 interaction and p21 expression during oxidative stress response in HGPS Mattioli, Elisabetta; Andrenacci, Davide; Garofalo, Cecilia; Prencipe, Sabino; Scotlandi, Katia; Remondini, Daniel; Gentilini, Davide; Di Blasio, Anna Maria; Valente, Sergio; Scarano, Emanuela; Cicchilitti, Lucia; Piaggio, Giulia; Mai, Antonello; Lattanzi, Giovanna - 01a Articolo in rivista
rivista: AGING CELL ([Oxford] : Blackwell Science Ltd, 2002-) pp. - - issn: 1474-9726 - wos: WOS:000445599100019 (30) - scopus: 2-s2.0-85052612287 (28)
11573/1147233 - 2018 -
Pyrazole-based inhibitors of enhancer of zeste homologue 2 induce apoptosis and autophagy in cancer cells Mellini, Paolo; Marrocco, Biagina; Borovika, Diana; Polletta, Lucia; Carnevale, Ilaria; Saladini, Serena; Stazi, Giulia; Zwergel, Clemens; Trapencieris, Peteris; Ferretti, Elisabetta; Tafani, Marco; Valente, Sergio; Mai, Antonello - 01a Articolo in rivista
rivista: PHILOSOPHICAL TRANSACTIONS - ROYAL SOCIETY. BIOLOGICAL SCIENCES (Royal Society of London) pp. 20170150- - issn: 0962-8436 - wos: WOS:000430738400014 (18) - scopus: 2-s2.0-85045959069 (19)
11573/1147245 - 2018 -
Nucleocytoplasmic export of HDAC5 and SIRT2 downregulation: two epigenetic mechanisms by which antidepressants enhance synaptic plasticity markers Muñoz-Cobo, I.; Erburu, M. M.; Zwergel, C.; Cirilli, Raffaela; Mai, A.; Valente, S.; Puerta, E.; Tordera, Rosa M. - 01a Articolo in rivista
rivista: PSYCHOPHARMACOLOGY (Heidelberg; Berlin: Springer) pp. 2831-2846 - issn: 0033-3158 - wos: WOS:000446140500005 (9) - scopus: 2-s2.0-85051492076 (7)
11573/1147237 - 2018 -
Combined HAT/EZH2 modulation leads to cancer-selective cell death Petraglia, Francesca; Singh, Abhishek A.; Carafa, Vincenzo; Nebbioso, Angela; Conte, Mariarosaria; Scisciola, Lucia; Valente, Sergio; Baldi, Alfonso; Mandoli, Amit; Petrizzi, Valeria Belsito; Ingenito, Concetta; De Falco, Sandro; Cicatiello, Valeria; Apicella, Ivana; Janssen-Megens, Eva M.; Kim, Bowon; Yi, Guoqiang; Logie, Colin; Heath, Simon; Ruvo, Menotti; Wierenga, Albertus T. J.; Flicek, Paul; Yaspo, Marie Laure; Della Valle, Veronique; Bernard, Olivier; Tomassi, Stefano; Novellino, Ettore; Feoli, Alessandra; Sbardella, Gianluca; Gut, Ivo; Vellenga, Edo; Stunnenberg, Hendrik G.; Mai, Antonello; Martens, Joost H. A.; Altucci, Lucia - 01a Articolo in rivista
rivista: ONCOTARGET (Albany, N.Y. : Impact Journals) pp. 25630-25646 - issn: 1949-2553 - wos: (0) - scopus: 2-s2.0-85047400725 (6)
11573/1120934 - 2018 -
HDAC1 inhibition by MS-275 in mesothelial cells limits cellular invasion and promotes MMT reversal Rossi, Lucia; Battistelli, Cecilia; De Turris, Valeria; Noce, Valeria; Zwergel, Clemens; Valente, Sergio; Moioli, Alessandra; Manzione, Andrea; Palladino, Marco; Bordoni, Veronica; Domenici, Alessandro; Mene', Paolo; Mai, Antonello; Tripodi, Marco; Strippoli, Raffaele - 01a Articolo in rivista
rivista: OPEN ACCESS SCIENTIFIC REPORTS (Los Angeles, CA : OMICS Publishing Group, [2012]-) pp. - - issn: 2332-2675 - wos: WOS:000433547600053 (22) - scopus: 2-s2.0-85048002226 (24)
11573/1147239 - 2018 -
Multi-omics profiling reveals a distinctive epigenome signature for high-risk acute promyelocytic leukemia Singh, Abhishek A.; Petraglia, Francesca; Nebbioso, Angela; Yi, Guoqiang; Conte, Mariarosaria; Valente, Sergio; Mandoli, Amit; Scisciola, Lucia; Lindeboom, Rik; Kerstens, Hinri; Janssen-Megens, Eva M.; Pourfarzad, Farzin; Habibi, Ehsan; Berentsen, Kim; Kim, Bowon; Logie, Colin; Heath, Simon; Wierenga, Albertus T. J.; Clarke, Laura; Flicek, Paul; Jansen, Joop H.; Kuijpers, Taco; Yaspo, Marie Laure; Della Valle, Veronique; Bernard, Olivier; Gut, Ivo; Vellenga, Edo; Stunnenberg, Hendrik G.; Mai, Antonello; Altucci, Lucia; Martens, Joost H. A. - 01a Articolo in rivista
rivista: ONCOTARGET (Albany, N.Y. : Impact Journals) pp. 25647-25660 - issn: 1949-2553 - wos: (0) - scopus: 2-s2.0-85047385574 (12)
11573/1202973 - 2018 -
Application of small epigenetic modulators in pediatric medulloblastoma Zwergel, Clemens; Romanelli, Annalisa; Stazi, Giulia; Besharat, Zein Mersini; Catanzaro, Giuseppina; Tafani, Marco; Valente, Sergio; Mai, Antonello - 01a Articolo in rivista
rivista: FRONTIERS IN PEDIATRICS (Lausanne : Frontiers Media S.A., 2013-) pp. - - issn: 2296-2360 - wos: WOS:000452081000001 (11) - scopus: 2-s2.0-85058706178 (12)
11573/1147235 - 2018 -
Trends of LSD1 inhibitors in viral infections Zwergel, Clemens; Stazi, Giulia; Mai, Antonello; Valente, Sergio - 01a Articolo in rivista
rivista: FUTURE MEDICINAL CHEMISTRY (London : Future Science, 2009-.) pp. 1133-1135 - issn: 1756-8919 - wos: WOS:000433568500001 (10) - scopus: 2-s2.0-85048066484 (10)
11573/1092479 - 2017 -
Effect of Class II HDAC inhibition on glutamate transporter expression and survival in SOD1-ALS mice Lapucci, Andrea; Cavone, Leonardo; Buonvicino, Daniela; Felici, Roberta; Gerace, Elisabetta; Zwergel, Clemens; Valente, Sergio; Mai, Antonello; Chiarugi, Alberto - 01a Articolo in rivista
rivista: NEUROSCIENCE LETTERS (Limerick Ireland: Elsevier Science Ireland Limited) pp. 120-125 - issn: 0304-3940 - wos: WOS:000409288600019 (19) - scopus: 2-s2.0-85026360880 (21)
11573/1192249 - 2017 -
Structure-activity relationships on cynnamoyl derivatives as inhibitors of p300 Histone acetyltransferase Madia, Valentina Noemi; Benedetti, Rosaria; Letizia Barreca, Maria; Ngo, Liza; Pescatori, Luca; Messore, Antonella; Pupo, Giovanni; Saccoliti, Francesco; Valente, Sergio; Mai, Antonello; Scipione, Luigi; George Zheng, Yujun; Tintori, Cristina; Botta, Maurizio; Cecchetti, Violetta; Altucci, Lucia; Di Santo, Roberto; Costi, Roberta - 01a Articolo in rivista
rivista: CHEMMEDCHEM (Weinheim : Wiley-VCH-Verl..) pp. 1359-1368 - issn: 1860-7187 - wos: WOS:000429592300014 (10) - scopus: 2-s2.0-85017448829 (9)
11573/972511 - 2017 -
Epi-drugs in combination with immunotherapy: a new avenue to improve anticancer efficacy Mazzone, Roberta; Zwergel, Clemens; Mai, Antonello; Valente, Sergio - 01a Articolo in rivista
rivista: CLINICAL EPIGENETICS (Berlin : Springer) pp. 1-15 - issn: 1868-7083 - wos: WOS:000403112500004 (110) - scopus: 2-s2.0-85020006586 (116)
11573/1017610 - 2017 -
The histone methyltransferase EZH2 as a druggable target in SHH medulloblastoma cancer stem cells Miele, Evelina; Valente, Sergio; Alfano, Vincenzo; Silvano, Marianna; Mellini, Paolo; Borovika, Diana; Marrocco, Biagina; Po, Agnese; Besharat, Zein Mersini; Catanzaro, Giuseppina; Battaglia, Giuseppe; Abballe, Luana; Zwergel, Clemens; Stazi, Giulia; Milite, Ciro; Castellano, Sabrina; Tafani, Marco; Trapencieris, Peteris; Mai, Antonello; Ferretti, Elisabetta - 01a Articolo in rivista
rivista: ONCOTARGET (Albany, N.Y. : Impact Journals) pp. 68557-68570- - issn: 1949-2553 - wos: WOS:000410790500145 (34) - scopus: 2-s2.0-85040235337 (36)
11573/1017602 - 2017 -
EZH2 inhibitors: a patent review (2014-2016) Stazi, Giulia; Zwergel, Clemens; Mai, Antonello; Valente, Sergio - 01a Articolo in rivista
rivista: EXPERT OPINION ON THERAPEUTIC PATENTS (--London United Kingdom:Informa Healthcare
-London, United Kingdom: Ashley Publications Limited) pp. 797-813 - issn: 1354-3776 - wos: WOS:000405302700004 (35) - scopus: 2-s2.0-85020639378 (36)
11573/955887 - 2017 -
Novel coumarin- and quinolinone-based polycycles as cell division cycle 25-A and -C phosphatases inhibitors induce proliferation arrest and apoptosis in cancer cells Zwergel, Clemens; Czepukojc, Brigitte; Evain Bana, Emilie; Xu, Zhanjie; Stazi, Giulia; Mori, Mattia; Patsilinakos, Alexandros; Mai, Antonello; Botta, Bruno; Ragno, Rino; Bagrel, Denise; Kirsch, Gilbert; Meiser, Peter; Jacob, Claus; Montenarh, Mathias; Valente, Sergio - 01a Articolo in rivista
rivista: EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY (Editions Scientifique & Medical Elsevier:23 Rue Linois, F 75724 Paris Cedex 15 France:011 33 1 71724646, INTERNET: http://www.elsevier.fr, Fax: 011 33 1 71724664) pp. 316-333 - issn: 0223-5234 - wos: WOS:000401677500027 (21) - scopus: 2-s2.0-85017548581 (24)
11573/851423 - 2016 -
Histone deacetylase inhibitors restore IL-10 expression in lipopolysaccharide-induced cell inflammation and reduce IL-1β and IL-6 production in breast silicone implant in C57BL/6J wild-type murine model Di Liddo, Rosa; Valente, Sergio; Taurone, Samanta; Zwergel, Clemens; Marrocco, Biagina; Turchetta, Rosaria; Conconi, Maria Teresa; Scarpa, Carlotta; Bertalot, Thomas; Schrenk, Sandra; Mai, Antonello; Artico, Marco - 01a Articolo in rivista
rivista: AUTOIMMUNITY (Amsterdam; New York: Harwood Academic Publishers.) pp. 1-11 - issn: 0891-6934 - wos: (0) - scopus: 2-s2.0-84955134169 (18)
11573/931824 - 2016 -
MC1568 inhibits HDAC6/8 activity and influenza A virus replication in lung epithelial cells: Role of Hsp90 acetylation Panella, Simona; Marcocci, Maria Elena; Celestino, Ignacio; Valente, Sergio; Zwergel, Clemens; Li Puma, Domenica Donatella; Nencioni, Lucia; Mai, Antonello; Palamara, Anna Teresa; Simonetti, Giovanna - 01a Articolo in rivista
rivista: FUTURE MEDICINAL CHEMISTRY (London : Future Science, 2009-.) pp. 2017-2031 - issn: 1756-8919 - wos: WOS:000386339500004 (27) - scopus: 2-s2.0-84994010342 (32)
11573/870518 - 2016 -
LSD1 inhibitors: a patent review (2010-2015) Stazi, Giulia; Zwergel, Clemens; Valente, Sergio; Mai, Antonello - 01a Articolo in rivista
rivista: EXPERT OPINION ON THERAPEUTIC PATENTS (--London United Kingdom:Informa Healthcare
-London, United Kingdom: Ashley Publications Limited) pp. 565-580 - issn: 1354-3776 - wos: WOS:000374900000003 (45) - scopus: 2-s2.0-84961644830 (46)
11573/870523 - 2016 -
1,4-Dihydropyridines Active on the SIRT1/AMPK Pathway Ameliorate Skin Repair and Mitochondrial Function and Exhibit Inhibition of Proliferation in Cancer Cells Valente, Sergio; Mellini, Paolo; Spallotta, Francesco; Carafa, Vincenzo; Nebbioso, Angela; Polletta, Lucia; Carnevale, Ilaria; Saladini, Serena; Trisciuoglio, Daniela; Gabellini, Chiara; Tardugno, Maria; Zwergel, Clemens; Cencioni, Chiara; Atlante, Sandra; Moniot, Sébastien; Steegborn, Clemens; Budriesi, Roberta; Tafani, Marco; Del Bufalo, Donatella; Altucci, Lucia; Gaetano, Carlo; Mai, Antonello - 01a Articolo in rivista
rivista: JOURNAL OF MEDICINAL CHEMISTRY (Washington, DC: American Chemical Society) pp. 1471-1491 - issn: 0022-2623 - wos: WOS:000371103600016 (52) - scopus: 2-s2.0-84959335947 (59)
11573/856751 - 2016 -
Discovery of a novel inhibitor of histone lysine-specific demethylase 1A (KDM1A/LSD1) as orally active antitumor agent Vianello, Paola; Botrugno, Oronza A; Cappa, Anna; Dal Zuffo, Roberto; Dessanti, Paola; Mai, Antonello; Marrocco, Biagina; Mattevi, Andrea; Meroni, Giuseppe; Minucci, Saverio; Stazi, Giulia; Thaler, Florian; Trifiró, Paolo; Valente, Sergio; Villa, Manuela; Varasi, Mario; Mercurio, Ciro - 01a Articolo in rivista
rivista: JOURNAL OF MEDICINAL CHEMISTRY (Washington, DC: American Chemical Society) pp. 1501-1517 - issn: 0022-2623 - wos: WOS:000371103600018 (57) - scopus: 2-s2.0-84959421233 (63)
11573/870553 - 2016 -
DNA methyltransferases Inhibitors from natural sources Zwergel, Clemens; Valente, Sergio; Mai, Antonello - 01a Articolo in rivista
rivista: CURRENT TOPICS IN MEDICINAL CHEMISTRY (Hilversum : Bentham Science Publishers) pp. 680-696 - issn: 1568-0266 - wos: WOS:000364586000004 (46) - scopus: 2-s2.0-84983215072 (51)
11573/884185 - 2015 -
Chronic stress and antidepressant induced changes in Hdac5 and Sirt2 affect synaptic plasticity Erburu, M.; Muñoz Cobo, I.; Domínguez Andrés, J.; Beltran, E.; Suzuki, T.; Mai, Antonello; Valente, Sergio; Puerta, E.; Tordera, R. M. - 01a Articolo in rivista
rivista: EUROPEAN NEUROPSYCHOPHARMACOLOGY (Elsevier BV:PO Box 211, 1000 AE Amsterdam Netherlands:011 31 20 4853757, 011 31 20 4853642, 011 31 20 4853641, EMAIL: nlinfo-f@elsevier.nl, INTERNET: http://www.elsevier.nl, Fax: 011 31 20 4853598) pp. 2036-2048 - issn: 0924-977X - wos: WOS:000369152500020 (47) - scopus: 2-s2.0-84947494371 (50)
11573/784167 - 2015 -
Novel histone deacetylase inhibitors induce growth arrest, apoptosis, and differentiation in sarcoma cancer stem cells G., Di Pompo; M., Salerno; Rotili, Dante; Valente, Sergio; Zwergel, Clemens; S., Avnet; G., Lattanzi; N., Baldini; Mai, Antonello - 01a Articolo in rivista
rivista: JOURNAL OF MEDICINAL CHEMISTRY (Washington, DC: American Chemical Society) pp. 4073-4079 - issn: 0022-2623 - wos: WOS:000354911200031 (52) - scopus: 2-s2.0-84929378676 (51)
11573/884225 - 2015 -
New insights on the mechanism of quinoline-based DNA methyltransferase inhibitors Gros, Christina; Fleury, Laurence; Nahoum, Virginie; Faux, Céline; Valente, Sergio; Labella, Donatella; Cantagrel, Frédéric; Rilova, Elodie; Bouhlel, Mohamed Amine; David Cordonnier, Marie Hélène; Dufau, Isabelle; Ausseil, Frédéric; Mai, Antonello; Mourey, Lionel; Lacroix, Laurent; Arimondo, Paola B. - 01a Articolo in rivista
rivista: THE JOURNAL OF BIOLOGICAL CHEMISTRY (American Society for Biochemistry and Molecular Biology:9650 Rockville Pike:Bethesda, MD 20814:(301)530-7145, EMAIL: asbmb@asbmb.faseb.org, INTERNET: http://www.faseb.org/asbmb, Fax: (301)571-1824) pp. 6293-6302 - issn: 0021-9258 - wos: WOS:000350732500035 (43) - scopus: 2-s2.0-84924897991 (47)
11573/870559 - 2015 -
Abstract 2946: Effects of two novel quinoline-based non-nucleoside DNA methyltransferase inhibitors against bone sarcomas Manara, Maria Cristina; Valente, Sergio; Cristalli, Camilla; Baricordi, Cristina; Zwergel, Clemens; Arimondo, Paola B; Picci, Piero; Mai, Antonello; Scotlandi, Katia - 04d Abstract in atti di convegno
rivista: CANCER RESEARCH (American Association of Cancer Research:150 South Independence Mall West, #826:Philadelphia, PA 19106:(215)440-9300, EMAIL: pubs@aacr.org, INTERNET: http://www.aacr.org, Fax: (215)440-7228) pp. 2946-2946 - issn: 0008-5472 - wos: WOS:000371578506091 (0) - scopus: (0)
11573/1667577 - 2015 -
PTPS-03EPIGENETIC SILENCING OF β-ARRESTIN1 AND ITS INTRAGENIC miR-326 CONTROLS MEDULLOBLASTOMA GROWTH Miele, Evelina; Mastronuzzi, Angela; Del Bufalo, Francesca; Po, Agnese; Valente, Sergio; Carai, Andrea; Screpanti, Isabella; Giangaspero, Felice; Levrero, Massimo; Locatelli, Franco; Ferretti, Elisabetta - 01h Abstract in rivista
rivista: NEURO-ONCOLOGY (First or current publisher Charlottesville, VA : Carden Jennings Pub., [1999-
Intervening publisher Durham, NC : Duke University Press
Current or last publisher Oxford, UK : Oxford University Press) pp. - - issn: 1523-5866 - wos: (0) - scopus: (0)
11573/856754 - 2015 -
Discovery of inhibitors for the ether lipid-generating enzyme AGPS as anti-cancer agents Piano, Valentina; Benjamin, Daniel I.; Valente, Sergio; Nenci, Simone; Marrocco, Biagina; Mai, Antonello; Aliverti, Alessandro; Nomura, Daniel K; Mattevi, Andrea - 01a Articolo in rivista
rivista: ACS CHEMICAL BIOLOGY (AMERICAN CHEMICAL SOCiety, 1155 16TH ST, NW, WASHINGTON, USA, DC, 20036) pp. 2589-2597 - issn: 1554-8929 - wos: WOS:000365462700020 (47) - scopus: 2-s2.0-84947909618 (48)
11573/784164 - 2015 -
Interplay among nucleosomal DNA, histone tails, and corepressor CoREST underlies LSD1-mediated H3 demethylation S., Pilotto; V., Speranzini; M., Tortorici; D., Durand; A., Fish; Valente, Sergio; F., Forneris; Mai, Antonello; T. K., Sixma; P., Vachette; A., Mattevi - 01a Articolo in rivista
rivista: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (National Academy of Sciences:2101 Constitution Avenue Northwest:Washington, DC 20418:(877)314-2253, (615)377-3322, EMAIL: subspnas@nas.edu, INTERNET: http://www.pnas.org, Fax: (615)377-0525) pp. 2752-2757 - issn: 0027-8424 - wos: WOS:000350224900048 (64) - scopus: 2-s2.0-84924368105 (67)
11573/781696 - 2015 -
Pure diastereomers of a tranylcypromine-based LSD1 inhibitor: enzyme selectivity and in-cell studies Valente, Sergio; Veronica, Rodriguez; Ciro, Mercurio; Paola, Vianello; Bruna, Saponara; Roberto, Cirilli; Giuseppe, Ciossani; Labella, Donatella; Marrocco, Biagina; Ruoppolo, Giovanni; Oronza A., Botrugno; Paola, Dessanti; Saverio, Minucci; Andrea, Mattevi; Mario, Varasi; Mai, Antonello - 01a Articolo in rivista
rivista: ACS MEDICINAL CHEMISTRY LETTERS (USA: ACS Publications) pp. 173-177 - issn: 1948-5875 - wos: WOS:000349652000012 (20) - scopus: 2-s2.0-84922867052 (17)
11573/781693 - 2015 -
Pure enantiomers of benzoylamino-tranylcypromine: LSD1 inhibition, gene modulation in human leukemia cells and effects on clonogenic potential of murine promyelocytic blasts Valente, Sergio; Veronica, Rodriguez; Mercurio, Ciro; Vianello, Paola; Saponara, Bruna; Cirilli, Roberto; Ciossani, Giuseppe; Labella, Donatella; Marrocco, Biagina; Monaldi, Daria; Ruoppolo, Giovanni; Tilset, Mats; Botrugno, Oronza A.; Dessanti, Paola; Minucci, Saverio; Mattevi, Andrea; Varasi, Mario; Mai, Antonello - 01a Articolo in rivista
rivista: EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY (Editions Scientifique & Medical Elsevier:23 Rue Linois, F 75724 Paris Cedex 15 France:011 33 1 71724646, INTERNET: http://www.elsevier.fr, Fax: 011 33 1 71724664) pp. 163-174 - issn: 0223-5234 - wos: WOS:000353730900016 (27) - scopus: 2-s2.0-84924406877 (28)
11573/779609 - 2015 -
Pyrrole- and indole-containing tranylcypromine derivatives as novel lysine-specific demethylase 1 inhibitors active on cancer cells. Veronica, Rodriguez; Valente, Sergio; Stefano, Rovida; Rotili, Dante; Stazi, Giulia; Lucidi, Alessia; Giuseppe, Ciossani; Andrea, Mattevi; Oronza A., Botrugno; Paola, Dessanti; Ciro, Mercurio; Paola, Vianello; Saverio, Minucci; Mario, Varasi; Mai, Antonello - 01a Articolo in rivista
rivista: MEDCHEMCOMM (Cambridge : Royal Society of Chemistry, 2010-) pp. 665-670 - issn: 2040-2503 - wos: WOS:000352903400023 (22) - scopus: 2-s2.0-84928004801 (23)
11573/884188 - 2015 -
Targeting lysine deacetylases (KDACs) in parasites Wang, Qi; Rosa, Bruce A.; Nare, Bakela; Powell, Kerrie; Valente, Sergio; Rotili, Dante; Mai, Antonello; Marshall, Garland R.; Mitreva, Makedonka - 01a Articolo in rivista
rivista: PLOS NEGLECTED TROPICAL DISEASES (San Francisco, CA : Public Library of Science) pp. e000426- - issn: 1935-2727 - wos: WOS:000363031200020 (38) - scopus: 2-s2.0-84943193825 (41)
11573/870535 - 2015 -
Emerging approaches for histone deacetylase inhibitor drug discovery Zwergel, Clemens; Valente, Sergio; Jacob, Claus; Mai, Antonello - 01a Articolo in rivista
rivista: EXPERT OPINION ON DRUG DISCOVERY (--London United Kingdom:Informa Healthcare
-London : Informa Healthcare, 2006-.) pp. 599-613 - issn: 1746-0441 - wos: WOS:000355006600004 (58) - scopus: 2-s2.0-84929928202 (64)
11573/557642 - 2014 -
Reversible acetylation regulates vascular endothelial growth factor receptor-2 activity A., Zecchin; L., Pattarini; M. I., Gutierrez; M., Mano; Mai, Antonello; Valente, Sergio; M. P., Myers; S., Pantano; M., Giacca - 01a Articolo in rivista
rivista: JOURNAL OF MOLECULAR CELL BIOLOGY (Shanghai : Journal of Molecular Cell Biology Editorial Office Oxford University Press) pp. 116-127 - issn: 1674-2788 - wos: WOS:000336081100003 (27) - scopus: 2-s2.0-84899675551 (31)
11573/1155213 - 2014 -
Sirtuins blunt reactive gliosis in an in vitro model of Alzheimer’s disease. Bronzuoli, Maria Rosanna; Scuderi, Caterina; Stecca, Claudia; Rotili, Dante; Valente, Sergio; Cugno, Michele; Mai, Antonello; Steardo, Luca. - 04d Abstract in atti di convegno
congresso: 17° Simposio SIF Dottorandi, Assegnisti di Ricerca Postdottorandi e Specializzandi in Farmacologia e Scienze Affini (Rimini)
libro: 17° Simposio SIF Dottorandi, Assegnisti di Ricerca Postdottorandi e Specializzandi in Farmacologia e Scienze Affini. - ()
11573/665415 - 2014 -
Novel inhibitors of human histone deacetylases: Design, synthesis and bioactivity of 3-alkenoylcoumarines C., Seidel; M., Schnekenburger; Zwergel, Clemens; F., Gaascht; Mai, Antonello; M., Dicato; G., Kirsch; Valente, Sergio; M., Diederich - 01a Articolo in rivista
rivista: BIOORGANIC & MEDICINAL CHEMISTRY LETTERS (Oxford: Pergamon, Amsterdam the Netherlands: Elsevier) pp. 3797-3801 - issn: 0960-894X - wos: WOS:000340565900024 (41) - scopus: 2-s2.0-84905916821 (45)
11573/557645 - 2014 -
Pharmacological inhibition of EZH2 as a promising differentiation therapy in embryonal RMS Ciarapica, R.; Carcarino, E.; Adesso, L.; De Salvo, Maria; Bracaglia, G.; Leoncini, P. P.; Dall'agnese, A.; Verginelli, F.; Milano, G. M.; Boldrini, R.; Inserra, A.; Stifani, S.; Screpanti, Isabella; Marquez, V. E.; Valente, Sergio; Mai, Antonello; Puri, P. L.; Locatelli, F.; Palacios, D.; Rota, R. - 01a Articolo in rivista
rivista: BMC CANCER (London: BioMed Central, [2001]-) pp. 139- - issn: 1471-2407 - wos: WOS:000332528100001 (48) - scopus: 2-s2.0-84898597003 (56)
11573/670458 - 2014 -
The Polycomb group (PcG) protein EZH2 supports the survival of PAX3-FOXO1 alveolar rhabdomyosarcoma by repressing FBXO32 (Atrogin1/MAFbx) Ciarapica, R.; De Salvo, Maria; Carcarino, E.; Bracaglia, G.; Adesso, Laura; Leoncini, P. P.; Dall'agnese, A.; Walters, Z. S.; Verginelli, F.; De Sio, L.; Boldrini, R.; Inserra, A.; Bisogno, G.; Rosolen, A.; Alaggio, R.; Ferrari, A.; Collini, P.; Locatelli, M.; Stifani, S.; Screpanti, Isabella; Rutella, S.; Yu, Q.; Marquez, V. E.; Shipley, J.; Valente, Sergio; Mai, Antonello; Miele, L.; Puri, P. L.; Locatelli, F.; Palacios, D.; Rota, R. - 01a Articolo in rivista
rivista: ONCOGENE (Macmillan Magazines Limited:Porters South Crinian Street, London N1 9XW United Kingdom:011 44 207 8334000, 011 44 171 8434982, Fax: 011 44 207 812358) pp. 4173-4184 - issn: 0950-9232 - wos: WOS:000340595700008 (56) - scopus: 2-s2.0-84905868284 (61)
11573/556419 - 2014 -
Context-Selective Death of Acute Myeloid Leukemia Cells Triggered by the Novel Hybrid Retinoid-HDAC Inhibitor MC2392. De Bellis, F; Carafa, V; Conte, M; Rotili, Dante; Petraglia, F; Matarese, F; Françoijs, Kj; Ablain, J; Valente, Sergio; Castellano, R; Goubard, A; Collette, Y; Mandoli, A; Martens, Jh; De Thé, H; Nebbioso, A; Mai, Antonello; Stunnenberg, Hg; Altucci, L. - 01a Articolo in rivista
rivista: CANCER RESEARCH (American Association of Cancer Research:150 South Independence Mall West, #826:Philadelphia, PA 19106:(215)440-9300, EMAIL: pubs@aacr.org, INTERNET: http://www.aacr.org, Fax: (215)440-7228) pp. 2328-2339 - issn: 0008-5472 - wos: WOS:000334584200020 (28) - scopus: 2-s2.0-84899541163 (33)
11573/664054 - 2014 -
PRMT1 arginine methyltransferase accumulates in cytoplasmic bodies that respond to selective inhibition and DNA damage J., Suchánková; S., Legartová; P., Sehnalová; S., Kozubek; Valente, Sergio; Labella, Donatella; Mai, Antonello; C., Eckerich; F. O., Fackelmayer; D. V., Sorokin; E., Bártová - 01a Articolo in rivista
rivista: EUROPEAN JOURNAL OF HISTOCHEMISTRY (Pavia : PagePress Publications, 2010) pp. 139-151 - issn: 2038-8306 - wos: WOS:000338624700013 (10) - scopus: 2-s2.0-84899705373 (9)
11573/799567 - 2014 -
Chalcone-Coumarin derivatives as potential anti-cancer drugs: an in vitro and in vivo investigation Jamier, Vincent; Marut, Wioleta; Valente, Sergio; Chereau, Christiane; Chouzenoux, Sandrine; Nicco, Carole; Lemarechal, Herve; Weill, Bernard; Kirsch, Gilbert; Jacob, Claus; Batteux, Frederic - 01a Articolo in rivista
rivista: ANTI-CANCER AGENTS IN MEDICINAL CHEMISTRY (Bussum : Bentham Science Publishers) pp. 963-974 - issn: 1875-5992 - wos: WOS:000341884600006 (27) - scopus: 2-s2.0-84905639421 (31)
11573/1705177 - 2014 -
Natural products molten together: Toward multifunctional hybrid molecules with specific activities and applications Kirsch, G.; Valente, S. - 02a Capitolo o Articolo
libro: Recent Advances in Redox Active Plant and Microbial Products - (978-94-017-8953-0)
11573/665613 - 2014 -
Sirtuin modulators: an updated patent review (2012 - 2014) P., Mellini; Valente, Sergio; Mai, Antonello - 01a Articolo in rivista
rivista: EXPERT OPINION ON THERAPEUTIC PATENTS (--London United Kingdom:Informa Healthcare
-London, United Kingdom: Ashley Publications Limited) pp. 5-15 - issn: 1354-3776 - wos: WOS:000346742700002 (45) - scopus: 2-s2.0-84919458504 (46)
11573/665612 - 2014 -
Synthesis, biological activity and mechanistic insights of 1-substituted cyclopropylamine derivatives: A novel class of irreversible inhibitors of histone demethylase KDM1A P., Vianello; O. A., Botrugno; A., Cappa; G., Ciossani; P., Dessanti; Mai, Antonello; A., Mattevi; G., Meroni; S., Minucci; F., Thaler; M., Tortorici; P., Trifiró; Valente, Sergio; M., Villa; M., Varasi; C., Mercurio - 01a Articolo in rivista
rivista: EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY (Editions Scientifique & Medical Elsevier:23 Rue Linois, F 75724 Paris Cedex 15 France:011 33 1 71724646, INTERNET: http://www.elsevier.fr, Fax: 011 33 1 71724664) pp. 352-363 - issn: 0223-5234 - wos: WOS:000343781800032 (48) - scopus: 2-s2.0-84906839626 (48)
11573/542432 - 2014 -
Pan-histone demethylase inhibitors simultaneously targeting Jumonji C and lysine-specific demethylases display high anticancer activities Rotili, Dante; Stefano, Tomassi; Mariarosaria, Conte; Rosaria, Benedetti; Marcello, Tortorici; Giuseppe, Ciossani; Valente, Sergio; Marrocco, Biagina; Labella, Donatella; Ettore, Novellino; Andrea, Mattevi; Lucia, Altucci; Tumber, Anthony; Yapp, Clarence; N. F., King Oliver; Richard J., Hopkinson; Akane, Kawamura; J., Schofield Christopher; Mai, Antonello - 01a Articolo in rivista
rivista: JOURNAL OF MEDICINAL CHEMISTRY (Washington, DC: American Chemical Society) pp. 42-55 - issn: 0022-2623 - wos: WOS:000329677800004 (91) - scopus: 2-s2.0-84892565144 (101)
11573/664039 - 2014 -
Evaluation of ∆2-pioglitazone, an analogue of pioglitazone, on colon cancer cell survival: Evidence of drug treatment association with autophagy and activation of the Nrf2/Keap1 pathway S., Huber; Valente, Sergio; P., Chaimbault; H., Schohn - 01a Articolo in rivista
rivista: INTERNATIONAL JOURNAL OF ONCOLOGY (National Hellenic Research Foundation:48 Vas Constatinou Avenue, Athens 11635 Greece:011 30 1 7241505, Fax: 011 30 1 7241505Editore attuale:PROFESSOR D A SPANDIDOS, 1, S MERKOURI ST, EDITORIAL OFFICE,, ATHENS, GREECE, 116 35.
Editore precedente:Editorial Academy of the International Journal of Oncology.) pp. 426-438 - issn: 1019-6439 - wos: WOS:000336881600046 (11) - scopus: 2-s2.0-84902598036 (11)
11573/643824 - 2014 -
Sirtuin modulators control reactive gliosis in an in vitro model of alzheimer's disease Scuderi, Caterina; Stecca, Claudia; Bronzuoli, Maria Rosanna; Rotili, Dante; Valente, Sergio; Mai, Antonello; Steardo, Luca - 01a Articolo in rivista
rivista: FRONTIERS IN PHARMACOLOGY (Lausanne: Frontiers Media S.A., 2010-) pp. - - issn: 1663-9812 - wos: WOS:000347086800001 (50) - scopus: 2-s2.0-84904631078 (56)
11573/664060 - 2014 -
1,3,4-Oxadiazole-Containing Histone Deacetylase Inhibitors: Anticancer Activities in Cancer Cells Valente, Sergio; D., Trisciuoglio; T., De Luca; A., Nebbioso; Labella, Donatella; Lenoci, Alessia; C., Bigogno; G. M., Dondio; M., Miceli; G., Brosch; D., Del Bufalo; L., Altucci; Mai, Antonello - 01a Articolo in rivista
rivista: JOURNAL OF MEDICINAL CHEMISTRY (Washington, DC: American Chemical Society) pp. 6259-6265 - issn: 0022-2623 - wos: WOS:000339540800033 (112) - scopus: 2-s2.0-84904962606 (111)
11573/664047 - 2014 -
Small-molecule inhibitors of histone deacetylase for the treatment of cancer and non-cancer diseases: a patent review (2011 - 2013). Valente, Sergio; Mai, Antonello - 01a Articolo in rivista
rivista: EXPERT OPINION ON THERAPEUTIC PATENTS (--London United Kingdom:Informa Healthcare
-London, United Kingdom: Ashley Publications Limited) pp. 401-415 - issn: 1354-3776 - wos: WOS:000333098200003 (42) - scopus: 2-s2.0-84896470334 (43)
11573/547528 - 2014 -
Selective Non-nucleoside Inhibitors of Human DNA Methyltransferases Active in Cancer Including in Cancer Stem Cells Valente, Sergio; Yiwei, Liu; Michael, Schnekenburger; Zwergel, Clemens; Sandro, Cosconati; Christina, Gros; Maria, Tardugno; Donatella, Labella; Cristina, Florean; Steven, Minden; Hideharu, Hashimoto; Yanqi, Chang; Xing, Zhang; Gilbert, Kirsch; Ettore, Novellino; Paola B., Arimondo; Miele, Evelina; Ferretti, Elisabetta; Gulino, Alberto; Marc, Diederich; Xiaodong, Cheng; Mai, Antonello - 01a Articolo in rivista
rivista: JOURNAL OF MEDICINAL CHEMISTRY (Washington, DC: American Chemical Society) pp. 701-713 - issn: 0022-2623 - wos: WOS:000331493000013 (94) - scopus: 2-s2.0-84894065301 (100)
11573/513469 - 2013 -
A Nitric Oxide-dependent crosstalk between class I and III Histone Deacetylases accelerates skin repair. 2. Spallotta, F.; Cencioni, C.; Straino, S.; Nanni, S.; Rosati, J.; Artuso, S.; Manni, I.; Colussi, C.; Piaggio, G.; Martelli, F.; Valente, Sergio; Mai, Antonello; Capogrossi, M. C.; Farsetti, A.; Gaetano, C. - 01a Articolo in rivista
rivista: THE JOURNAL OF BIOLOGICAL CHEMISTRY (American Society for Biochemistry and Molecular Biology:9650 Rockville Pike:Bethesda, MD 20814:(301)530-7145, EMAIL: asbmb@asbmb.faseb.org, INTERNET: http://www.faseb.org/asbmb, Fax: (301)571-1824) pp. 11004-11012 - issn: 0021-9258 - wos: WOS:000317915500007 (64) - scopus: 2-s2.0-84876580701 (69)
11573/525990 - 2013 -
Oxidative stress and epigenetic regulation in ageing and age-related diseases Chiara, Cencioni; Spallotta, Francesco; Fabio, Martelli; Valente, Sergio; Mai, Antonello; Zeiher Am, Gaetano C. - 01a Articolo in rivista
rivista: INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (Basel (Matthaeustrasse 11) : Molecular Diversity Preservation International MDPI) pp. 17643-17663 - issn: 1661-6596 - wos: WOS:000328623900021 (145) - scopus: 2-s2.0-84883479431 (166)
11573/529785 - 2013 -
A novel coumarin-quinone derivative SV37 inhibits CDC25 phosphatases, impairs proliferation, and induces cell death. Emilie, Bana; Sibille, Estelle; Valente, Sergio; Claudia, Cerella; Patrick, Chaimbault; Kirsch, Gilbert; Mario, Dicato; Marc, Diederich; Denyse, Bagrel - 01a Articolo in rivista
rivista: MOLECULAR CARCINOGENESIS (editore attuale: WILEY-LISS, DIV JOHN WILEY & SONS INC, 111 RIVER ST, HOBOKEN, USA, NJ, 07030.
editore precedente: New York, NY : Wiley-Liss.) pp. n/a-n/a - issn: 0899-1987 - wos: WOS:000347828600006 (25) - scopus: 2-s2.0-84926088320 (31)
11573/513467 - 2013 -
Inhibition of Class I Histone Deacetylases Unveils a Mitochondrial Signature and Enhances Oxidative Metabolism in Skeletal Muscle and Adipose Tissue. Galmozzi, A.; Mitro, N.; Ferrari, A.; Gers, E.; Gilardi, F.; Godio, C.; Cermenati, G.; Gualerzi, A.; Donetti, E.; Rotili, Dante; Valente, Sergio; Guerrini, U.; Caruso, D.; Mai, Antonello; Saez, E.; De Fabiani, E.; Crestani, M. - 01a Articolo in rivista
rivista: DIABETES (American Diabetes Association:National Service Center, 1701 North Beaureguard Street:Alexandria, VA 22311:(800)232-3472, (703)549-1500, INTERNET: http://www.diabetes.org/diabetscare, Fax: (703)549-6995) pp. 732-742 - issn: 0012-1797 - wos: WOS:000315556400017 (177) - scopus: 2-s2.0-84869106554 (191)
11573/513468 - 2013 -
Class II HDAC Inhibition Hampers Hepatic Stellate Cell Activation by Induction of MicroRNA-29 Inge, Mannaerts; Nathalie, Eysackers; Oscar O., Onyema; Katrien Van, Beneden; Valente, Sergio; Mai, Antonello; Margarete, Odenthal; Leo A., Van Grunsven - 01a Articolo in rivista
rivista: PLOS ONE (San Francisco, CA : Public Library of Science) pp. e55786- - issn: 1932-6203 - wos: WOS:000314610600159 (55) - scopus: 2-s2.0-84873122711 (61)
11573/525042 - 2013 -
Detrimental effect of class-selective histone deacetylase inhibitors during tissue regeneration following hindlimb ischemia Spallotta, F.; Silvia, Tardivo; Nanni, S.; Rosati, J. D.; Straino, S.; Mai, Antonello; Vecellio, M.; Valente, Sergio; Capogrossi, M. C.; Farsetti, A.; Martone, Julie; Bozzoni, Irene; Pontecorvi, A.; Gaetano, C.; Colussi, C. - 01a Articolo in rivista
rivista: THE JOURNAL OF BIOLOGICAL CHEMISTRY (American Society for Biochemistry and Molecular Biology:9650 Rockville Pike:Bethesda, MD 20814:(301)530-7145, EMAIL: asbmb@asbmb.faseb.org, INTERNET: http://www.faseb.org/asbmb, Fax: (301)571-1824) pp. 22915-22929 - issn: 0021-9258 - wos: WOS:000330598200004 (27) - scopus: 2-s2.0-84881396773 (25)
11573/514588 - 2013 -
tert-Butylcarbamate-Containing Histone Deacetylase Inhibitors: Apoptosis Induction, Cytodifferentiation, and Antiproliferative Activities in Cancer Cells. Valente, Sergio; Trisciuoglio, D; Tardugno, M; Benedetti, R; Labella, Donatella; Secci, Daniela; Mercurio, C; Boggio, R; Tomassi, S; Di Maro, S; Novellino, E; Altucci, L; Del Bufalo, D; Mai, Antonello; Cosconati, S. - 01a Articolo in rivista
rivista: CHEMMEDCHEM (Weinheim : Wiley-VCH-Verl..) pp. - - issn: 1860-7179 - wos: WOS:000318245300013 (15) - scopus: 2-s2.0-84877064105 (17)
11573/525043 - 2013 -
Reactivity of 4-vinyl-2H-1-benzopyran-2-ones in diels-alder cycloaddition reactions: Access to coumarin-based polycycles with Cdc25 phosphatase-inhibiting activity Valente, Sergio; Zhanjie, Xu; Emilie, Bana; Zwergel, Clemens; Mai, Antonello; Jacob, Claus; Peter, Meiser; Denyse, Bagrel; Artur M. S., Silva; Kirsch, Gilbert - 01a Articolo in rivista
rivista: EUROPEAN JOURNAL OF ORGANIC CHEMISTRY (Wiley-VCH Verlag GmBH:PO Box 101161, D 69451 Weinheim Germany:011 49 6201 606147, EMAIL: service@wiley-vch.de, INTERNET: http://www.wiley-vch.de, Fax: 011 49 6201 606328) pp. 2869-2877 - issn: 1434-193X - wos: WOS:000318803200018 (11) - scopus: 2-s2.0-84877688906 (12)
11573/870542 - 2013 -
Novel benzofuran-chromone and -coumarin derivatives: Synthesis and biological activity in K562 human leukemia cells Zwergel, Clemens; Valente, Sergio; Salvato, Angela; Xu, Zhanjie; Talhi, Oualid; Mai, Antonello; Silva, Artur; Altucci, Lucia; Kirsch, Gilbert - 01a Articolo in rivista
rivista: MEDCHEMCOMM (Cambridge : Royal Society of Chemistry, 2010-) pp. 1571-1579 - issn: 2040-2503 - wos: WOS:000327461300005 (45) - scopus: 2-s2.0-84888154287 (49)
11573/485036 - 2012 -
Amino acid starvation induces reactivation of silenced transgenes and latent HIV-1 provirus via down-regulation of histone deacetylase 4 (HDAC4) I., Palmisano; G., Della Chiara; R. L., D'ambrosio; C., Huichalaf; P., Brambilla; S., Corbetta; M., Riba; R., Piccirillo; Valente, Sergio; G., Casari; Mai, Antonello; F., Martinelli Boneschi; D., Gabellini; G., Poli; M. V., Schiaffino - 01a Articolo in rivista
rivista: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (National Academy of Sciences:2101 Constitution Avenue Northwest:Washington, DC 20418:(877)314-2253, (615)377-3322, EMAIL: subspnas@nas.edu, INTERNET: http://www.pnas.org, Fax: (615)377-0525) pp. E2284-E2293 - issn: 0027-8424 - wos: WOS:000308085200011 (31) - scopus: 2-s2.0-84865194183 (36)
11573/443820 - 2012 -
Coumarin polysulfides inhibit cell growth and induce apoptosis in HCT116 colon cancer cells Nathaniel Edward Bennett, Saidu; Valente, Sergio; Emilie, Bana; Gilbert, Kirsch; Denyse, Bagrel; Mathias, Montenarh - 01a Articolo in rivista
rivista: BIOORGANIC & MEDICINAL CHEMISTRY (Oxford: Pergamon, 1993-) pp. 1584-1593 - issn: 0968-0896 - wos: WOS:000300391200024 (59) - scopus: 2-s2.0-84857033328 (62)
11573/513460 - 2012 -
Developing novel non-hydroxamate histone deacetylase inhibitors: the chelidamic warhead. Valente, Sergio; Conte, M.; Tardugno, M.; Nebbioso, A; Tinari, G.; Altucci, L.; Mai, Antonello - 01a Articolo in rivista
rivista: MEDCHEMCOMM (Cambridge : Royal Society of Chemistry, 2010-) pp. 298-304 - issn: 2040-2503 - wos: WOS:000301966800004 (5) - scopus: 2-s2.0-84857707526 (6)
11573/455694 - 2012 -
Identification of PR-SET7 and EZH2 selective inhibitors inducing cell death in human leukemia U937 cells Valente, Sergio; Ilaria, Lepore; Carmela, Dell'aversa; Maria, Tardugno; Sabrina, Castellano; Gianluca, Sbardella; Stefano, Tomassi; Salvatore Di, Maro; Ettore, Novellino; Di Santo, Roberto; Costi, Roberta; Lucia, Altucci; Mai, Antonello - 01a Articolo in rivista
rivista: BIOCHIMIE (Editions Scientifique & Medical Elsevier:23 Rue Linois, F 75724 Paris Cedex 15 France:011 33 1 71724646, INTERNET: http://www.elsevier.fr, Fax: 011 33 1 71724664) pp. 2308-2313 - issn: 0300-9084 - wos: WOS:000310929200011 (22) - scopus: 2-s2.0-84867395419 (26)
11573/525900 - 2012 -
Aurones: Interesting Natural and Synthetic Compounds with Emerging Biological Potential Zwergel, Clemens; F., Gaascht; Valente, Sergio; M., Diederich; D., Bagrel; G., Kirsch - 01a Articolo in rivista
rivista: NATURAL PRODUCT COMMUNICATIONS (Park Lane, Westerville, Usa : Natural Product, Inc.
7963) pp. 389-394 - issn: 1934-578X - wos: WOS:000301897900022 (61) - scopus: 2-s2.0-84860770231 (62)
11573/414595 - 2011 -
Novel 3,5-bis(bromohydroxybenzylidene)piperidin-4-ones as coactivator-associated arginine methyltransferase 1 inhibitors: Enzyme selectivity and cellular activity Donghang, Cheng; Valente, Sergio; Sabrina, Castellano; Gianluca, Sbardella; Di Santo, Roberto; Costi, Roberta; Mark T., Bedford; Mai, Antonello - 01a Articolo in rivista
rivista: JOURNAL OF MEDICINAL CHEMISTRY (Washington, DC: American Chemical Society) pp. 4928-4932 - issn: 0022-2623 - wos: WOS:000292479600049 (64) - scopus: 2-s2.0-79960191524 (70)
11573/443817 - 2011 -
Application of 3 μm particle-based amylose-derived chiral stationary phases for the enantioseparation of potential histone deacetylase inhibitors. Ferretti, R; Mai, Antonello; Gallinella, B; Zanitti, L; Valente, Sergio; Cirilli, R. - 01a Articolo in rivista
rivista: JOURNAL OF CHROMATOGRAPHY A (Elsevier BV:PO Box 211, 1000 AE Amsterdam Netherlands:011 31 20 4853757, 011 31 20 4853642, 011 31 20 4853641, EMAIL: nlinfo-f@elsevier.nl, INTERNET: http://www.elsevier.nl, Fax: 011 31 20 4853598) pp. 8394-8398 - issn: 0021-9673 - wos: WOS:000297036000012 (18) - scopus: 2-s2.0-80054874258 (19)
11573/526018 - 2011 -
Facile synthesis of 4-acetyl-coumarins, -thiocoumarin and -quinolin-2(1H)-one via very high α-regioselective Heck coupling on tosylates Valente, Sergio; Kirsch, Gilbert - 01a Articolo in rivista
rivista: TETRAHEDRON LETTERS (Oxford; New York; Paris; Frankfurt: Pergamon Press, 1959-) pp. 3429-3432 - issn: 0040-4039 - wos: WOS:000292413800005 (19) - scopus: 2-s2.0-79957940869 (19)
11573/525044 - 2011 -
Histone deacetylase inhibitors (epigenetic alterations)Targeted Therapies for Hepatocellular Carcinoma Valente, Sergio; Mai, Antonello - 02a Capitolo o Articolo
libro: Targeted Therapies for Hepatocellular Carcinoma - (9781780840628)
11573/436635 - 2011 -
Novel Reversible Monoamine Oxidase A Inhibitors: Highly Potent and Selective 3-(1H-Pyrrol-3-yl)-2-oxazolidinones Valente, Sergio; S., Tomassi; Tempera, Giampiero; Saccoccio, Stefania; Agostinelli, Enzo; Mai, Antonello - 01a Articolo in rivista
rivista: JOURNAL OF MEDICINAL CHEMISTRY (Washington, DC: American Chemical Society) pp. 8228-8232 - issn: 0022-2623 - wos: WOS:000297445400024 (32) - scopus: 2-s2.0-82555187393 (32)
11573/356064 - 2011 -
Novel Cinnamyl Hydroxyamides and 2-Aminoanilides as Histone Deacetylase Inhibitors: Apoptotic Induction and Cytodifferentiation Activity Valente, Sergio; Tardugno, Maria; Mariarosaria, Conte; Roberto, Cirilli; Andrea, Perrone; Ragno, Rino; Simeoni, Silvia; Tramontano, Anna; Massa, Silvio; Angela, Nebbioso; Marco, Miceli; Gianluigi, Franci; Gerald, Brosch; Lucia, Altucci; Mai, Antonello - 01a Articolo in rivista
rivista: CHEMMEDCHEM (Weinheim : Wiley-VCH-Verl..) pp. 698-712 - issn: 1860-7179 - wos: WOS:000288814900016 (15) - scopus: 2-s2.0-79953046146 (16)
11573/434969 - 2010 -
HDACs class II-selective inhibition alters nuclear receptor-dependent differentiation A., Nebbioso; C., Dell'aversana; A., Bugge; R., Sarno; Valente, Sergio; Rotili, Dante; F., Manzo; D., Teti; S., Mandrup; P., Ciana; A., Maggi; Mai, Antonello; H., Gronemeyer; L., Altucci - 01a Articolo in rivista
rivista: JOURNAL OF MOLECULAR ENDOCRINOLOGY (Pubblicata da:
SOC ENDOCRINOLOGY, 22 APEX COURT, WOODLANDS, BRADLEY STOKE, BRISTOL, ENGLAND, BS32 4JT
primo editore:
Journal of Endocrinology Limited:17 18 Courtyard Woodlands, Bristol BS12 4NQ United Kingdom:011 44 117 9616046, EMAIL: sxa15@psu.edu, INTERNET: http://www.psu.edu, Fax: 011 44 117 9616071) pp. 219-228 - issn: 0952-5041 - wos: WOS:000282528800005 (51) - scopus: 2-s2.0-77957824326 (55)
11573/365281 - 2010 -
Biochemical, Structural, and Biological Evaluation of Tranylcypromine Derivatives as Inhibitors of Histone Demethylases LSD1 and LSD2 Claudia, Binda; Valente, Sergio; Mauro, Romanenghi; Simona, Pilotto; Roberto, Cirilli; Aristotele, Karytinos; Giuseppe, Ciossani; Oronza A., Botrugno; Federico, Forneris; Maria, Tardugno; Dale E., Edmondson; Saverio, Minucci; Andrea, Mattevi; Mai, Antonello - 01a Articolo in rivista
rivista: JOURNAL OF THE AMERICAN CHEMICAL SOCIETY ([Washington, USA: American Chemical Society] 1879-) pp. 6827-6833 - issn: 0002-7863 - wos: WOS:000277721500044 (231) - scopus: 2-s2.0-77952355653 (248)
11573/434968 - 2010 -
TNF/p38α/polycomb signaling to Pax7 locus in satellite cells links inflammation to the epigenetic control of muscle regeneration Daniela, Palacios; Mozzetta, Chiara; Silvia, Consalvi; Giuseppina, Caretti; Valentina, Saccone; Valentina, Proserpio; Victor E., Marquez; Valente, Sergio; Mai, Antonello; Sonia V., Forcales; Vittorio, Sartorelli; Pier Lorenzo, Puri - 01a Articolo in rivista
rivista: CELL STEM CELL (Cambridge: Cell Press (an imprint of Elsevier)) pp. 455-469 - issn: 1934-5909 - wos: WOS:000283270600008 (304) - scopus: 2-s2.0-77957357566 (328)
11573/895420 - 2010 -
Evaluation of histone deacetylases as drug targets in Huntington's disease models Quinti, Luisa; Chopra, Vanita; Rotili, Dante; Valente, Sergio; Amore, Allison; Franci, Gianluigi; Meade, Sarah; Valenza, Marta; Altucci, Lucia; Maxwell, Michele M.; Cattaneo, Elena; Hersch, Steven; Mai, Antonello; Kazantsev, Aleksey - 02a Capitolo o Articolo
libro: PLOS CURRENTS - ()
11573/229552 - 2010 -
Nitric oxide determines mesodermic differentiation of mouse embryonic stem cells by activating class IIa histone deacetylases: potential therapeutic implications in a mouse model of hindlimb ischemia Spallotta, F; Rosati, J; Straino, S; Nanni, S; Grasselli, A; Ambrosino, V; Rotili, Dante; Valente, Sergio; Farsetti, A; Mai, Antonello; Capogrossi, Mc; Gaetano, C; Illi, B. - 01a Articolo in rivista
rivista: STEM CELLS (Alphamed Press Incorporated:1 Prestige Place, Suite 290:Miamisburg, OH 45342:(937)291-2355, EMAIL: alphamedpress@alphamedpress.com, INTERNET: http://www.alphamedpress.com, Fax: (937)291-4229) pp. 431-442 - issn: 1066-5099 - wos: WOS:000277093700006 (48) - scopus: 2-s2.0-77950581254 (47)
11573/443480 - 2010 -
Synthesis and biological evaluation of novel coumarin-based inhibitors of Cdc25 phosphatases Valente, Sergio; Emilie, Bana; Elodie, Viry; Denyse, Bagrel; Gilbert, Kirsch - 01a Articolo in rivista
rivista: BIOORGANIC & MEDICINAL CHEMISTRY LETTERS (Oxford: Pergamon, Amsterdam the Netherlands: Elsevier) pp. 5827-5830 - issn: 0960-894X - wos: WOS:000281735600049 (35) - scopus: 2-s2.0-77957590019 (36)
11573/229551 - 2009 -
Shock and kill" effects of class I-selective histone deacetylase inhibitors in combination with the glutathione synthesis inhibitor buthionine sulfoximine in cell line models for HIV-1 quiescence Andrea, Savarino; Mai, Antonello; Sandro, Norelli; Sary El, Daker; Valente, Sergio; Rotili, Dante; Lucia, Altucci; Palamara, Anna Teresa; Enrico, Garaci - 01a Articolo in rivista
rivista: RETROVIROLOGY (London : BioMed Central) pp. 52-52 - issn: 1742-4690 - wos: WOS:000267430700001 (96) - scopus: 2-s2.0-67649259174 (96)
11573/442678 - 2009 -
Histone deacetylase inhibitors and neurodegenerative disorders: Holding the promise Mai, Antonello; Rotili, Dante; Valente, Sergio; Aleksey, Kazantsev - 01a Articolo in rivista
rivista: CURRENT PHARMACEUTICAL DESIGN (Bentham Science Publishers BV:PO Box 7917, Exec Ste Y 26, Saif Zone Sharjah Uae:011 971 6 5571132, EMAIL: benthams@emirates.net.ae, INTERNET: http://www.bentham.org, Fax: 011 971 6 5571134) pp. 3940-3957 - issn: 1381-6128 - wos: WOS:000271385600003 (69) - scopus: 2-s2.0-70649108817 (70)
11573/229211 - 2009 -
New pyrrole-based histone deacetylase inhibitors: Binding mode, enzyme- and cell-based investigations Mai, Antonello; Valente, Sergio; Angela, Nebbioso; Simeoni, Silvia; Ragno, Rino; Silvio, Massa; Gerald, Brosch; Floriana De, Bellis; Fabio, Manzo; Lucia, Altucci - 01a Articolo in rivista
rivista: THE INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY (Applied Science Publishers:Ripple Road, Barking Essex United Kingdom) pp. 235-247 - issn: 1357-2725 - wos: WOS:000262620400028 (24) - scopus: 2-s2.0-55949088703 (26)
11573/12799 - 2009 -
Study of 1,4-Dihydropyridine Structural Scaffold: Discovery of Novel Sirtuin Activators and Inhibitors Mai, Antonello; Valente, Sergio; Sarah, Meade; Vincenzo, Carafa; Maria, Tardugno; Angela, Nebbioso; Andrea, Galmozzi; Nico, Mitro; Emma De, Fabiani; Lucia, Altucci; Aleksey, Kazantsev - 01a Articolo in rivista
rivista: JOURNAL OF MEDICINAL CHEMISTRY (Washington, DC: American Chemical Society) pp. 5496-5504 - issn: 0022-2623 - wos: WOS:000269655500022 (144) - scopus: 2-s2.0-69949096844 (150)
11573/12746 - 2009 -
Pyrrole-Based Hydroxamates and 2-Aminoanilides: Histone Deacetylase Inhibition and Cellular Activities Mariarosaria, Conte; Maria, Tardugno; Silvio, Massa; Angela, Nebbioso; Lucia, Altucci; Mai, Antonello; Valente, Sergio - 01a Articolo in rivista
rivista: CHEMMEDCHEM (Weinheim : Wiley-VCH-Verl..) pp. 1411-1415 - issn: 1860-7179 - wos: WOS:000270027800002 (10) - scopus: 2-s2.0-69749113873 (10)
11573/13427 - 2009 -
Histone post-translational modifications by HPLC-ESI-MS after HT29 cell treatment with HDAC inhibitors Marina, Naldi; Natalia, Calonghi; Lanfranco, Masotti; Carola, Parolin; Valente, Sergio; Mai, Antonello; Vincenza, Andrisano - 01a Articolo in rivista
rivista: PROTEOMICS (Wiley-VCH Verlag GmBH:PO Box 101161, D 69451 Weinheim Germany:011 49 6201 606147, EMAIL: service@wiley-vch.de, INTERNET: http://www.wiley-vch.de, Fax: 011 49 6201 606328) pp. 5437-5445 - issn: 1615-9853 - wos: WOS:000273515000006 (22) - scopus: 2-s2.0-73149088831 (26)
11573/434973 - 2009 -
Selective class II HDAC inhibitors impair myogenesis by modulating the stability and activity of HDAC-MEF2 complexes. Nebbioso, A; Manzo, F; Miceli, M; Conte, M; Manente, L; Baldi, A; De Luca, A; Rotili, Dante; Valente, Sergio; Mai, Antonello; Usiello, A; Gronemeyer, H; Altucci, L. - 01a Articolo in rivista
rivista: EMBO REPORTS (Oxford : Oxford University Press, 2000-) pp. 776-782 - issn: 1469-221X - wos: WOS:000267599700022 (116) - scopus: 2-s2.0-67650083046 (119)
11573/13144 - 2008 -
HDAC-class II specific inhibition involves HDAC proteasome-dependent degradation mediated by RANBP2 Annamaria, Scognamiglio; Angela, Nebbioso; Fabio, Manzo; Valente, Sergio; Mai, Antonello; Lucia, Altucci - 01a Articolo in rivista
rivista: BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH (Elsevier BV:PO Box 211, 1000 AE Amsterdam Netherlands:011 31 20 4853757, 011 31 20 4853642, 011 31 20 4853641, EMAIL: nlinfo-f@elsevier.nl, INTERNET: http://www.elsevier.nl, Fax: 011 31 20 4853598) pp. 2030-2038 - issn: 0167-4889 - wos: WOS:000259917200036 (47) - scopus: 2-s2.0-50849143144 (49)
11573/358405 - 2008 -
Nitric oxide modulates chromatin folding in human endothelial cells via protein phosphatase 2A activation and class II histone deacetylases nuclear shuttling Illi, B.; Dello Russo, Claudio; Colussi, C.; Rosati, J.; Pallaoro, M.; Spallotta, F.; Rotili, Dante; Valente, Sergio; Ragone, G.; Martelli, F.; Biglioli, P.; Steinkuhler, C.; Gallinari, P.; Mai, Antonello; Capogrossi, M. C.; Gaetano, C. - 01a Articolo in rivista
rivista: CIRCULATION RESEARCH (Lippincott, Williams & Wilkins:530 Walnut Street:Philadelphia, PA 19106:(800)638-3030, (301)223-2300, EMAIL: orders@lww.com, INTERNET: http://www.lww.com, Fax: (301)223-2320, (301)223-2320
PRimo editore:
Baltimore, Md. : Grune & Stratton, c1953-) pp. 51-58 - issn: 0009-7330 - wos: WOS:000252217400009 (96) - scopus: 2-s2.0-37849010584 (99)
11573/13425 - 2008 -
Epigenetric Multiple Ligands: Mixed Histone/Protein Methyltransferase, Acetyltransferase, and Class III Deacetylase (Sirtuin) Inhibitors Mai, A.; Cheng, D; Bedford, M. T.; Valente, S; Nebbioso, A; Perrone, A; Brosch, G; Sbardella, G; De Bellis, F; Miceli, M; Altucci, L - 01a Articolo in rivista
rivista: JOURNAL OF MEDICINAL CHEMISTRY (Washington, DC: American Chemical Society) pp. 2279-2290 - issn: 0022-2623 - wos: WOS:000254709100033 (122) - scopus: 2-s2.0-41849146748 (128)
11573/363936 - 2008 -
Novel uracil-based 2-aminoanilide and 2-aminoanilide-like derivatives: Histone deacetylase inhibition and in-cell activities Mai, Antonello; Andrea, Perrone; Angela, Nebbioso; Rotili, Dante; Valente, Sergio; Maria, Tardugno; Silvio, Massa; Floriana De, Bellis; Lucia, Altucci - 01a Articolo in rivista
rivista: BIOORGANIC & MEDICINAL CHEMISTRY LETTERS (Oxford: Pergamon, Amsterdam the Netherlands: Elsevier) pp. 2530-2535 - issn: 0960-894X - wos: WOS:000255246400002 (24) - scopus: 2-s2.0-41849089386 (27)
11573/13369 - 2008 -
Specific Activity of Class II Histone Deacetylases in Human Breast Cancer Cells V., Duong; C., Bret; L., Altucci; Mai, Antonello; C., Duraffourd; J., Loubersac; P. O., Harmand; S., Bonnet; Valente, Sergio; T., Maudelonde; V., Cavailles; N., Boulle - 01a Articolo in rivista
rivista: MOLECULAR CANCER RESEARCH (American Association of Cancer Research:150 South Independence Mall West, #826:Philadelphia, PA 19106:(215)440-9300, EMAIL: pubs@aacr.org, INTERNET: http://www.aacr.org, Fax: (215)440-7228) pp. 1908-1919 - issn: 1541-7786 - wos: WOS:000261824800011 (81) - scopus: 2-s2.0-57749101152 (91)
11573/362130 - 2007 -
Identification of two new synthetic histone deacetylase inhibitors that modulate globin gene expression in erythroid cells from healthy donors and patients with thalassemia Mai, Antonello; K., Jelicic; Rotili, Dante; A., Di Noia; E., Alfani; Valente, Sergio; L., Altucci; A., Nebbioso; S., Massa; R., Galanello; G., Brosch; A. R., Migliaccio; G., Migliaccio - 01a Articolo in rivista
rivista: MOLECULAR PHARMACOLOGY (American Society for Pharmacology and Experimental Therapeutics:9650 Rockville Pike:Bethesda, MD 20814:(301)530-7024, EMAIL: pstoute@aspet.org, INTERNET: http://www.aspet.org, Fax: (301)634-7099) pp. 1111-1123 - issn: 0026-895X - wos: WOS:000250385300004 (29) - scopus: 2-s2.0-35548933854 (30)
11573/240206 - 2007 -
Synthesis and biological validation of novel synthetic histone/protein methyltransferase inhibitors Mai, Antonello; Valente, Sergio; Donghang, Cheng; Andrea, Perrone; Ragno, Rino; Simeoni, Silvia; Gianluca, Sbardella; Gerald, Brosch; Mark T, Bedford - 01a Articolo in rivista
rivista: CHEMMEDCHEM (Weinheim : Wiley-VCH-Verl..) pp. 987-991 - issn: 1860-7179 - wos: WOS:000248065600003 (53) - scopus: 2-s2.0-41849112166 (52)
11573/364545 - 2007 -
Novel pyrrole-containing histone deacetylase inhibitors endowed with cytodifferentiation activity Mai, Antonello; Valente, Sergio; Rotili, Dante; Silvio, Massa; Giorgia, Botta; Gerald, Brosch; Marco, Miceli; Angela, Nebbioso; Lucia, Altucci - 01a Articolo in rivista
rivista: THE INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY (Applied Science Publishers:Ripple Road, Barking Essex United Kingdom) pp. 1510-1522 - issn: 1357-2725 - wos: WOS:000248566700025 (14) - scopus: 2-s2.0-34447268739 (14)
11573/51660 - 2007 -
New Aroyl-Pyrrolyl-Hydroxy-Amides APHAs: Class I and II Histone Deacetylase Inhibiting Activity and Binding Mode Analysis through Molecular Docking Experiments Ragno, Rino; Mai, Antonello; Simeoni, Silvia; Caroli, Antonia; Valente, Sergio; Perrone, Andrea - 04a Atto di comunicazione a congresso
congresso: Frontiers in CNS and Oncology Medicinal Chemistry, ACS-EFMC (Siena, Italy)
libro: Frontiers in CNS and Oncology Medicinal Chemistry, ACS-EFMC - ()
11573/234238 - 2006 -
Aroyl-pyrrolyl hydroxyamides: Influence of pyrrole C4-phenylacetyl substitution on histone deacetylase inhibition Mai, Antonello; Silvio, Massa; Valente, Sergio; Silvia, Simeoni; Ragno, Rino; Patrizia, Bottoni; Roberto, Scatena; Gerald, Brosch - 01a Articolo in rivista
rivista: CHEMMEDCHEM (Weinheim : Wiley-VCH-Verl..) pp. 225-237 - issn: 1860-7179 - wos: WOS:000202945600008 (21) - scopus: 2-s2.0-33646483786 (22)
11573/234818 - 2006 -
3-D QSAR Studies on Histone Deacetylase Inhibitors. A GOLPE/GRID Approach on Different Series of Compounds. Ragno, Rino; Simeoni, S; Valente, Sergio; Massa, S; Mai, Antonello - 01a Articolo in rivista
rivista: JOURNAL OF CHEMICAL INFORMATION AND MODELING (AMER CHEMICAL SOC, 1155 16TH ST, NW, WASHINGTON, USA, DC, 20036) pp. 1420-1430 - issn: 1549-9596 - wos: WOS:000237658400053 (40) - scopus: 2-s2.0-33745356936 (45)
11573/365771 - 2005 -
3-(1H-Pyrrol-2-yl)-2-oxazolidinones as novel monoamine oxidase type A inhibitors. Mai, A; Artico, M.; Valente, S; Sbardella, G; Turini, P; Befani, O; Dalla Vedova, L; Agostinelli, E - 01a Articolo in rivista
rivista: MEDICINAL CHEMISTRY (Bentham Science Publishers Ltd) pp. 117-124 - issn: 1573-4064 - wos: (0) - scopus: 2-s2.0-33846116762 (7)
11573/526020 - 2005 -
Histone Deacetylation in Epigenetics: An Attractive Target for Anticancer Therapy Mai, Antonello; Massa, S; Rotili, Dante; Cerbara, I; Valente, Sergio; Pezzi, R; Simeoni, S; Ragno, Rino - 01a Articolo in rivista
rivista: MEDICINAL RESEARCH REVIEWS (John Wiley & Sons Incorporated:Customer Service, 111 River Street:Hoboken, NJ 07030:(800)225-5945, (201)748-6000, EMAIL: societyinfo@wiley.com, INTERNET: http://www.wiley.com, Fax: (212)748-6551) pp. 261-309 - issn: 0198-6325 - wos: WOS:000228224900001 (298) - scopus: 2-s2.0-16844362441 (315)
11573/13036 - 2005 -
Synthesis and biological evaluation of 2-, 3-, and 4-acylaminocinnamyl-N-hydroxyamides as novel synthetic HDAC inhibitors. Mai, Antonello; S., Massa; R., Pezzi; P., Loidl; G., Brosch; Valente, Sergio - 01a Articolo in rivista
rivista: MEDICINAL CHEMISTRY (Bentham Science Publishers Ltd) pp. 245-254 - issn: 1573-4064 - wos: (0) - scopus: 2-s2.0-25144492801 (27)
11573/240328 - 2004 -
Synthesis and biochemical evaluation of (R)-5-acyloxymethyl- and (S)-5-acylaminomethyl-3-(1H-pyrrol-1-yl)-2-oxazolidinones as new anti-monoamine oxidase (anti-MAO) agents. Mai, Antonello; Artico, Marino; Valente, Sergio; I., Cerbara; Befani, Olivia; Turini, Paola; L., Dalla Vedova; Agostinelli, Enzo - 01a Articolo in rivista
rivista: ARKIVOC (ARKAT USA INC, C/O ALAN R KATRITZKY, UNIV FLORIDA, DEPT CHEMISTRY, PO BOX 117200, GAINESVILLE, USA, FL, 32611) pp. 23-43 - issn: 1551-7004 - wos: WOS:000222493900004 (6) - scopus: (0)
11573/13659 - 2004 -
Antimalarial and Antileishmanial Activities of Aroyl-pyrrolyl-hydroxy-amides, a New Class of Histone Deacetylase Inhibitors Mai, Antonello; I., Cerbara; Valente, Sergio; S., Massa; L. A., Walker; B. L., Tekwani - 01a Articolo in rivista
rivista: ANTIMICROBIAL AGENTS AND CHEMOTHERAPY (American Society for Microbiology:PO Box 11127:Birmingham, AL 35201:(800)633-4931, (205)995-1567, EMAIL: asm.nonmembers.subs@ebsco.com, INTERNET: http://www.asm.org, Fax: (205)995-1588) pp. 1435-1436 - issn: 0066-4804 - wos: WOS:000220658600060 (49) - scopus: 2-s2.0-1642460965 (50)
11573/234811 - 2004 -
3-(4-Aroyl-1-methyl-1H-2-pyrrolyl)-N-hydroxy-2-propenamides as a New Class of Synthetic Histone Deacetylase Inhibitors. 2. Effect of Pyrrole-C2 and/or -C4 Substitutions on Biological Activity Mai, Antonello; S., Massa; I., Cerbara; Valente, Sergio; Ragno, Rino; P., Bottoni; R., Scatena; P., Loidl; G., Brosch - 01a Articolo in rivista
rivista: JOURNAL OF MEDICINAL CHEMISTRY (Washington, DC: American Chemical Society) pp. 1098-1109 - issn: 0022-2623 - wos: WOS:000189151500005 (60) - scopus: 2-s2.0-1242273835 (66)
11573/434777 - 2004 -
3-(4-Aroyl-1-methyl-1H-pyrrol-2-yl)-N-hydroxy-2-propenamides as a new class of synthetic histone deacetylase inhibitors. 3. Discovery of novel lead compounds through structure-based drug design and docking studies. Ragno, Rino; Mai, Antonello; Massa, S; Cerbara, I; Valente, Sergio; Bottoni, P; Scatena, R; Jesacher, F; Loidl, P; Brosch, G. - 01a Articolo in rivista
rivista: JOURNAL OF MEDICINAL CHEMISTRY (Washington, DC: American Chemical Society) pp. - - issn: 0022-2623 - wos: WOS:000220038700008 (64) - scopus: 2-s2.0-12144291023 (69)
11573/218667 - 2003 -
3-(1H-pyrrol-2- and –3-yl)-2-oxazolidinones as novel potent and selective monoamine oxidase type A inhibitors. Mai, Antonello; Cervara, I.; Valente, Sergio; Artico, Marino; Sbardella, G.; Befani, Olivia; Turini, Paola; Agostinelli, Enzo - 13a Altro ministeriale
11573/204734 - 2003 -
3-(1H-pyrrol-2- and –3-yl)-2-oxazolidinones as novel potent and selective monoamine oxidase type A inhibitors. Mai, Antonello; I., Cervara; Valente, Sergio; Artico, Marino; G., Sbardella; Befani, Olivia; Turini, Paola; Agostinelli, Enzo - 04a Atto di comunicazione a congresso
libro: 8th International Congress on Amino Acids and Proteins - ()