11573/1658358 - 2023 -
Chemically diverse S. mansoni HDAC8 inhibitors reduced viability in worm larval and adult stages Noce, Beatrice; Di Bello, Elisabetta; Zwergel, Clemens; Fioravanti, Rossella; Valente, Sergio; Rotili, Dante; Ansari, Mohammad Salik Zeya; Trisciuoglio, Daniela; Mai, Antonello - 01a Articolo in rivista
paper: CHEMMEDCHEM (Weinheim : Wiley-VCH-Verl..) pp. - - issn: 1860-7179 - wos: WOS:000879912800001 (0) - scopus: 2-s2.0-85141693563 (0)
11573/1662777 - 2023 -
Novel pyridine-containing histone deacetylase inhibitors strongly arrest proliferation, induce apoptosis and modulate miRNAs in cancer cells Di Bello, Elisabetta; Bontempi, Giulio; Zwergel, Clemens; Fioravanti, Rossella; Noce, Beatrice; Castiello, Carola; Corinti, Davide; Tripodi, Marco; Strippoli, Raffaele; Valente, Sergio; Mai, Antonello - 01a Articolo in rivista
paper: EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY (Editions Scientifique & Medical Elsevier:23 Rue Linois, F 75724 Paris Cedex 15 France:011 33 1 71724646, INTERNET: http://www.elsevier.fr, Fax: 011 33 1 71724664) pp. 115022- - issn: 0223-5234 - wos: WOS:000911596400001 (0) - scopus: 2-s2.0-85144323384 (0)
11573/1669899 - 2023 -
METTL3 from Target Validation to the First Small-Molecule Inhibitors: A Medicinal Chemistry Journey Fiorentino, Francesco; Menna, Martina; Rotili, Dante; Valente, Sergio; Mai, Antonello - 01g Articolo di rassegna (Review)
paper: JOURNAL OF MEDICINAL CHEMISTRY (Washington DC : ACS Publications) pp. 1654-1677 - issn: 1520-4804 - wos: (0) - scopus: 2-s2.0-85147012551 (0)
11573/1673946 - 2023 -
Role of SIRT3 in Microgravity Response: A New Player in Muscle Tissue Recovery Aventaggiato, Michele; Barreca, Federica; Valente, Sergio; Rotili, Dante; Mai, Antonello; Lotti, Lavinia Vittoria; Sansone, Luigi; Russo, Matteo Antonio; Bizzarri, Mariano; Ferretti, Elisabetta; Tafani, Marco - 01a Articolo in rivista
paper: CELLS (Basel: mdpi-Molecular Diversity Preservation International) pp. 691- - issn: 2073-4409 - wos: (0) - scopus: (0)
11573/1674091 - 2023 -
GreenMedChem- the challenge in the next decade toward eco-friendly compounds and processes in drug design Castiello, Carola; Valente, Sergio; Rotili, Dante; Fioravanti, Rossella; Zwergel, Clemens; Mai, Antonello - 01g Articolo di rassegna (Review)
paper: GREEN CHEMISTRY (Royal Society of Chemistry:Thomas Graham House, Science Park, Cambridge CB4 0WF United Kingdom:011 44 1223 432360, EMAIL: sales@rsc.org, INTERNET: http://www.rsc.org, http://www.chensoc.org, Fax: 011 44 1223 423429) pp. 2109-2169 - issn: 1463-9262 - wos: (0) - scopus: (0)
11573/1612791 - 2022 -
Inhibition of PKCθ Improves Dystrophic Heart Phenotype and Function in a Novel Model of DMD Cardiomyopathy Morroni, Jacopo; Schirone, Leonardo; Zwergel, Clemens; Sanchez Riera, Carles; Valente, Sergio; Vecchio, Daniele; Schiavon, Sonia; Ragno, Rino; Mai, Antonello; Sciarretta, Sebastiano; Lozanoska Ochser, Biliana; Bouche', Marina - 01a Articolo in rivista
paper: INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (Basel: MDPI Center) pp. 1-16 - issn: 1422-0067 - wos: WOS:000772462700001 (0) - scopus: 2-s2.0-85124895071 (0)
11573/1614439 - 2022 -
Cytoplasmic HDAC4 regulates the membrane repair mechanism in Duchenne muscular dystrophy Renzini, Alessandra; Marroncelli, Nicoletta; Cavioli, Giorgia; Di Francescantonio, Silvia; Forcina, Laura; Valente, Sergio; Mai, Antonello; Giampietri, Claudia; Magenta, Alessandra; De Santa, Francesca; Adamo, Sergio; Coletti, Dario; Moresi, Viviana - 01a Articolo in rivista
paper: JOURNAL OF CACHEXIA, SARCOPENIA AND MUSCLE (Heidelberg ; Berlin : Springer) pp. 1339-1359 - issn: 2190-5991 - wos: WOS:000755498900001 (6) - scopus: 2-s2.0-85124595217 (6)
11573/1623442 - 2022 -
Targeting the anti-apoptotic Bcl-2 family proteins: Machine learning virtual screening and biological evaluation of new small molecules Montesano, Camilla; Patsilinakos, Alexandros; Sabatino, Manuela; Antonini, Lorenzo; Valente, Sergio; Mai, Antonello; Colotti, Gianni; Ragno, Rino - 01a Articolo in rivista
paper: THERANOSTICS (Wyoming, N.S.W. : Ivyspring International Publisher, 2011-) pp. 2427-2444 - issn: 1838-7640 - wos: WOS:000766737800003 (1) - scopus: 2-s2.0-85126080507 (0)
11573/1623778 - 2022 -
Heterocycle-containing tranylcypromine derivatives endowed with high anti-LSD1 activity Fioravanti, Rossella; Di Bello, Elisabetta; Noce, Beatrice; Zwergel, Clemens; Corinti, Davide; Valente, Sergio; Mai, Antonello - 01a Articolo in rivista
paper: JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY (Taylor & Francis Limited:Rankine Road, Basingstoke RG24 8PR United Kingdom:011 44 1256 813035, EMAIL: madeline.sims@tandf.co.uk, info@tandf.co.uk, INTERNET: http://www.tandf.co.uk, Fax: 011 44 1256 330245) pp. 973-985 - issn: 1475-6366 - wos: WOS:000771778600001 (0) - scopus: 2-s2.0-85126852334 (0)
11573/1650772 - 2022 -
Effects of Structurally Different HDAC Inhibitors against Trypanosoma cruzi, Leishmania, and Schistosoma mansoni Di Bello, Elisabetta; Noce, Beatrice; Fioravanti, Rossella; Zwergel, Clemens; Valente, Sergio; Rotili, Dante; Mai, Antonello - 01a Articolo in rivista
paper: ACS INFECTIOUS DISEASES (Washington, DC : American Chemical Society, 2015-) pp. 1356-1366-1366 - issn: 2373-8227 - wos: WOS:000819851400001 (7) - scopus: 2-s2.0-85134360722 (7)
11573/1657657 - 2022 -
Potent and Specific Activators for Mitochondrial Sirtuins Sirt3 and Sirt5 Valente, Sergio; Zwergel, Clemens; Di Bello, Elisabetta; Fioravanti, Rossella; Aventaggiato, Michele; Tafani, Marco; Mai, Antonello - 01a Articolo in rivista
paper: JOURNAL OF MEDICINAL CHEMISTRY (Washington, DC: American Chemical Society) pp. 14015-14031 - issn: 0022-2623 - wos: WOS:000878509000001 (0) - scopus: 2-s2.0-85140303478 (0)
11573/1659806 - 2022 -
Restoration of WT1/miR-769-5p axis by HDAC1 inhibition promotes MMT reversal in mesenchymal-like mesothelial cells Bontempi, Giulio; Terri, Michela; Garbo, Sabrina; Montaldo, Claudia; Valente, Sergio; Zwergel, Clemens; Mai, Antonello; Marchetti, Alessandra; Mene', Paolo; Battistelli, Cecilia; Tripodi, Marco; Strippoli, Raffaele - 01a Articolo in rivista
paper: CELL DEATH & DISEASE (Nature Group) pp. - - issn: 2041-4889 - wos: WOS:000885083500004 (1) - scopus: 2-s2.0-85142134241 (2)
11573/1467228 - 2021 -
Novel Pyridine-Based Hydroxamates and 2'-Aminoanilides as Histone Deacetylase Inhibitors: Biochemical Profile and Anticancer Activity Zwergel, Clemens; Di Bello, Elisabetta; Fioravanti, Rossella; Mazzone, Roberta; Valente, Sergio; Mai, Antonello - 01a Articolo in rivista
paper: CHEMMEDCHEM (Weinheim : Wiley-VCH-Verl..) pp. 989-999 - issn: 1860-7179 - wos: WOS:000599084500001 (4) - scopus: 2-s2.0-85097525146 (4)
11573/1550470 - 2021 -
Structure-Guided Development of Small-Molecule PRC2 Inhibitors Targeting EZH2–EED Interaction Zwergel, Clemens; Valente, Sergio - 01a Articolo in rivista
paper: JOURNAL OF MEDICINAL CHEMISTRY (Washington, DC: American Chemical Society) pp. 8194-8207 - issn: 0022-2623 - wos: WOS:000668340800017 (10) - scopus: 2-s2.0-85108541842 (12)
11573/1564224 - 2021 -
Histone-deacetylase 8 drives the immune response and the growth of glioma Mormino, Alessandro; Cocozza, Germana; Valente, Sergio; Esposito, Vincenzo; Santoro, Antonio; Bernardini, Giovanni; Santoni, Angela; Fazi, Francesco; Mai, Antonello; Limatola, Cristina; Garofalo, Stefano - 01a Articolo in rivista
paper: GLIA (John Wiley & Sons Incorporated:Customer Service, 111 River Street:Hoboken, NJ 07030:(800)225-5945, (201)748-6000, EMAIL: societyinfo@wiley.com, INTERNET: http://www.wiley.com, Fax: (212)748-6551) pp. 1-17 - issn: 0894-1491 - wos: WOS:000678875900001 (6) - scopus: 2-s2.0-85111697220 (6)
11573/1564901 - 2021 -
Polycomb repressive complex 2 modulation through the development of EZH2–EED interaction inhibitors and EED binders Romanelli, Annalisa; Zwergel, Clemens; Valente, Sergio; Mai, Antonello - 01g Articolo di rassegna (Review)
paper: JOURNAL OF MEDICINAL CHEMISTRY (Washington, DC: American Chemical Society) pp. 11774-11797 - issn: 0022-2623 - wos: WOS:000692012400002 (9) - scopus: 2-s2.0-85114048578 (11)
11573/1565876 - 2021 -
Editorial: new approaches to tackle EMT and fibrosis: from epigenetics to nanotechnology Battistelli, Cecilia; Valente, Sergio; Strippoli, Raffaele - 01m Editorial/Introduzione in rivista
paper: FRONTIERS IN PHARMACOLOGY (Lausanne: Frontiers Media S.A., 2010-) pp. - - issn: 1663-9812 - wos: WOS:000686867300001 (0) - scopus: 2-s2.0-85113221898 (0)
11573/1613681 - 2021 -
Editorial: Natural Product Epigenetic Modulators and Inhibitors Valente, Sergio; Battistelli, Cecilia - 01m Editorial/Introduzione in rivista
paper: FRONTIERS IN PHARMACOLOGY (Lausanne: Frontiers Media S.A., 2010-) pp. - - issn: 1663-9812 - wos: WOS:000629965700001 (1) - scopus: 2-s2.0-85102865581 (1)
11573/1361035 - 2020 -
Molecular mechanisms and new therapeutic targets in epithelial to mesenchymal transition (EMT) and fibrosis Strippoli, Raffaele; Battistelli, Cecilia; Valente, Sergio - 01m Editorial/Introduzione in rivista
paper: FRONTIERS IN PHARMACOLOGY (Lausanne: Frontiers Media S.A., 2010-) pp. - - issn: 1663-9812 - wos: WOS:000510209700001 (1) - scopus: 2-s2.0-85078745922 (1)
11573/1364390 - 2020 -
Novel quinoline compounds active in cancer cells through coupled DNA methyltransferase inhibition and degradation Zwergel, Clemens; Fioravanti, Rossella; Stazi, Giulia; Battistelli, Cecilia; Romanelli, Annalisa; Lopes Mendes, Ana Ludy Da Conceicao; Strippoli, Raffaele; Tripodi, Marco; Valente, Sergio; Mai, Antonello - 01a Articolo in rivista
paper: CANCERS (Basel : MDPI) pp. - - issn: 2072-6694 - wos: WOS:000522477300193 (6) - scopus: 2-s2.0-85079504263 (6)
11573/1382315 - 2020 -
Tranylcypromine-based LSD1 inhibitors: structure-activity relationships, antiproliferative effects in leukemia, and gene target modulation Fioravanti, Rossella; Romanelli, Annalisa; Mautone, Nicola; Di Bello, Elisabetta; Rovere, Annarita; Corinti, Davide; Zwergel, Clemens; Valente, Sergio; Rotili, Dante; Mai, Antonello - 01a Articolo in rivista
paper: CHEMMEDCHEM (Weinheim : Wiley-VCH-Verl..) pp. 643-658 - issn: 1860-7179 - wos: WOS:000513271600001 (13) - scopus: 2-s2.0-85079446800 (15)
11573/1390388 - 2020 -
Targeting the scaffolding role of LSD1 (KDM1A) poises acute myeloid leukemia cells for retinoic acid-induced differentiation Valente, Sergio; Fioravanti, Rossella; Mai, Antonello - 01a Articolo in rivista
paper: SCIENCE ADVANCES (Washington, DC : American Association for the Advancement of Science, 2015-) pp. - - issn: 2375-2548 - wos: WOS:000525751400003 (31) - scopus: 2-s2.0-85083269142 (30)
11573/1390390 - 2020 -
A closer look into NADPH oxidase inhibitors: validation and insight into their mechanism of action Valente, Sergio; Mai, Antonello - 01a Articolo in rivista
paper: REDOX BIOLOGY (Amsterdam : Elsevier) pp. - - issn: 2213-2317 - wos: WOS:000537459900002 (35) - scopus: 2-s2.0-85079650979 (37)
11573/1390392 - 2020 -
Altered mitochondrial function in cells carrying a premutation or unmethylated full mutation of the FMR1 gene Ragno, Rino; Stazi, Giulia; Valente, Sergio; Mai, Antonello - 01a Articolo in rivista
paper: HUMAN GENETICS (Germany: Springer Verlag Germany) pp. 227-245 - issn: 0340-6717 - wos: WOS:000515839900006 (13) - scopus: 2-s2.0-85077526115 (13)
11573/1394955 - 2020 -
Design of first-in-class dual EZH2/HDAC inhibitor: biochemical activity and biological evaluation in cancer cells Romanelli, Annalisa; Stazi, Giulia; Fioravanti, Rossella; Zwergel, Clemens; Di Bello, Elisabetta; Battistelli, Cecilia; Strippoli, Raffaele; Tripodi, Marco; Mai, Antonello; Valente, Sergio - 01a Articolo in rivista
paper: ACS MEDICINAL CHEMISTRY LETTERS (USA: ACS Publications) pp. 977-983 - issn: 1948-5875 - wos: WOS:000535281200056 (27) - scopus: 2-s2.0-85087681122 (29)
11573/1414757 - 2020 -
Discovery of the first human arylsulfatase a reversible inhibitor impairing mouse oocyte fertilization Zwergel, Clemens; Pirolli, Adele; Sabatino, Manuela; Mai, Antonello; Altieri, Fabio; Canipari, Rita; Valente, Sergio; Ragno, Rino - 01a Articolo in rivista
paper: ACS CHEMICAL BIOLOGY (AMERICAN CHEMICAL SOCiety, 1155 16TH ST, NW, WASHINGTON, USA, DC, 20036) pp. 1349-1357 - issn: 1554-8929 - wos: WOS:000543662300010 (3) - scopus: 2-s2.0-85086748074 (3)
11573/1418417 - 2020 -
The innovative potential of statins in cancer: new targets for new therapies Di Bello, Elisabetta; Zwergel, Clemens; Mai, Antonello; Valente, Sergio - 01g Articolo di rassegna (Review)
paper: FRONTIERS IN CHEMISTRY (Lausanne : Frontiers Media S.A., 2013-) pp. - - issn: 2296-2646 - wos: WOS:000546786300001 (46) - scopus: 2-s2.0-85087290374 (50)
11573/1429805 - 2020 -
Properly substituted cyclic Bis-(2-bromobenzylidene) compounds behaved as dual p300/CARM1 Inhibitors and Induced apoptosis in cancer cells Fioravanti, Rossella; Di Bello, Elisabetta; Romanelli, Annalisa; Plateroti, Andrea Maria; Valente, Sergio; Mai, Antonello - 01a Articolo in rivista
paper: MOLECULES (Basel: MDPI
Berlin: Springer, 1996-) pp. - - issn: 1420-3049 - wos: WOS:000558002500001 (1) - scopus: 2-s2.0-85088202424 (1)
11573/1434640 - 2020 -
CDK9 as a valuable target in cancer: from natural compounds inhibitors to current treatment in pediatric soft tissue sarcomas Fioravanti, Rossella; Valente, Sergio; Rotili, Dante; Mai, Antonello - 01a Articolo in rivista
paper: FRONTIERS IN PHARMACOLOGY (Lausanne: Frontiers Media S.A., 2010-) pp. - - issn: 1663-9812 - wos: WOS:000565986100001 (14) - scopus: 2-s2.0-85089884656 (17)
11573/1193778 - 2019 -
Identification of novel quinazoline derivatives as potent antiplasmodial agents Rotili, Dante; Valente, Sergio; Mazzone, Roberta; Lucidi, Alessia; Fabrizi, Giancarlo; Mai, Antonello - 01a Articolo in rivista
paper: EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY (Editions Scientifique & Medical Elsevier:23 Rue Linois, F 75724 Paris Cedex 15 France:011 33 1 71724646, INTERNET: http://www.elsevier.fr, Fax: 011 33 1 71724664) pp. 277-291 - issn: 0223-5234 - wos: WOS:000451498200018 (32) - scopus: 2-s2.0-85055197167 (36)
11573/1208206 - 2019 -
Development of alkyl glycerone phosphate synthase inhibitors: Structure-activity relationship and effects on ether lipids and epithelial-mesenchymal transition in cancer cells Stazi, Giulia; Battistelli, Cecilia; Mazzone, Roberta; Marrocco, Biagina; Zwergel, Clemens; Antonini, Lorenzo; Patsilinakos, Alexandros; Ragno, Rino; Ciogli, Alessia; Fabrizi, Giancarlo; Strippoli, Raffaele; Marchetti, Alessandra; Tripodi, Marco; Mattevi, Andrea; Mai, Antonello; Valente, Sergio - 01a Articolo in rivista
paper: EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY (Editions Scientifique & Medical Elsevier:23 Rue Linois, F 75724 Paris Cedex 15 France:011 33 1 71724646, INTERNET: http://www.elsevier.fr, Fax: 011 33 1 71724664) pp. 722-735 - issn: 0223-5234 - wos: WOS:000458597300053 (12) - scopus: 2-s2.0-85058530369 (12)
11573/1265927 - 2019 -
Identification of a novel quinoline-based DNA demethylating compound highly potent in cancer cells Zwergel, Clemens; Battistelli, Cecilia; Stazi, Giulia; Mazzone, Roberta; Fioravanti, Rossella; Strippoli, Raffaele; Tripodi, Marco; Mai, Antonello; Valente, Sergio - 01a Articolo in rivista
paper: CLINICAL EPIGENETICS (Berlin : Springer) pp. - - issn: 1868-7083 - wos: WOS:000467227900001 (24) - scopus: 2-s2.0-85065468885 (23)
Zwergel, Clemens; Rotili, Dante; Valente, Sergio; Mai, Antonello - 02a Capitolo o Articolo
book: Epigenetic Drug Discovery - (9783527343140; 9783527809257)
11573/1275490 - 2019 -
Epigenetic Pharmacology in Regenerative Medicine (Epi-Drugs) Stazi, Giulia; Zwergel, Clemens; Valente, Sergio; Mai, Antonello - 02a Capitolo o Articolo
book: Epigenetics and Regeneration - (9780128148792)
11573/1339079 - 2019 -
Dissecting the role of novel EZH2 inhibitors in primary glioblastoma cell cultures: effects on proliferation, epithelial-mesenchymal transition, migration, and on the pro-inflammatory phenotype Stazi, Giulia; Taglieri, Ludovica; Nicolai, Alice; Romanelli, Annalisa; Fioravanti, Rossella; Morrone, Stefania; Sabatino, Manuela; Ragno, Rino; Taurone, Samanta; Nebbioso, Marcella; Carletti, Raffaella; Artico, Marco; Valente, Sergio; Scarpa, Susanna; Mai, Antonello - 01a Articolo in rivista
paper: CLINICAL EPIGENETICS (Berlin : Springer) pp. 1-17 - issn: 1868-7083 - wos: WOS:000501362500004 (37) - scopus: 2-s2.0-85076062797 (37)
11573/1382317 - 2019 -
Lysine methyltransferases and their inhibitors Stazi, Giulia; Zwergel, Clemens; Valente, Sergio - 02a Capitolo o Articolo
book: Chemical Epigenetics - (978-3-030-42981-2; 978-3-030-42982-9)
11573/1390394 - 2019 -
The Protein Arginine Methyltransferases 1 and 5 affect Myc properties in glioblastoma stem cells Valente, Sergio; Mai, Antonello; Scagnoli, Fiorella - 01a Articolo in rivista
paper: SCIENTIFIC REPORTS (London : Nature Publishing Group) pp. 15925- - issn: 2045-2322 - wos: WOS:000493898100033 (21) - scopus: 2-s2.0-85074323285 (23)
11573/1390396 - 2019 -
Histone deacetylases contribute to excitotoxicity-triggered degeneration of retinal ganglion cells in vivo Fioravanti, Rossella; Valente, Sergio; Mai, Antonello - 01a Articolo in rivista
paper: MOLECULAR NEUROBIOLOGY (Humana Press Incorporated:999 Riverview Drive, Suite 208:Totowa, NJ 07512:(973)256-1699, EMAIL: lglasner@humanapr.com, INTERNET: http://www.humanapress.com, Fax: (973)256-8341) pp. 8018-8034 - issn: 0893-7648 - wos: WOS:000494860800008 (14) - scopus: 2-s2.0-85067067374 (14)
11573/1390399 - 2019 -
Statins and histone deacetylase inhibitors affect lamin A/C - histone deacetylase 2 interaction in human cells Mai, Antonello; Valente, Sergio - 01a Articolo in rivista
paper: FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY (Lausanne : Frontiers Media S.A., 2013-) pp. - - issn: 2296-634X - wos: WOS:000467197300001 (16) - scopus: 2-s2.0-85075855435 (13)
11573/1416968 - 2019 -
Histone deacetylases as an epigenetic pillar for the development of hybrid inhibitors in cancer Stazi, Giulia; Fioravanti, Rossella; Mai, Antonello; Valente, Sergio - 01g Articolo di rassegna (Review)
paper: CURRENT OPINION IN CHEMICAL BIOLOGY (Current Biology Limited:84 Theobalds Road, London WC1X 8RR United Kingdom:011 44 20 76114202, EMAIL: info@biomednet.com, INTERNET: http://www.biomednet.com, Fax: 011 44 20 76114479) pp. 89-100 - issn: 1367-5931 - wos: WOS:000473839100012 (20) - scopus: 2-s2.0-85064167463 (22)
11573/1074176 - 2018 -
Targeting the CoREST complex with dual histone deacetylase and demethylase inhibitors Valente, Sergio; Mai, Antonello; Mattevi, Andrea - 01a Articolo in rivista
paper: NATURE COMMUNICATIONS (London: Nature Publishing Group) pp. - - issn: 2041-1723 - wos: WOS:000419404200003 (139) - scopus: 2-s2.0-85040217796 (137)
11573/1120934 - 2018 -
HDAC1 inhibition by MS-275 in mesothelial cells limits cellular invasion and promotes MMT reversal Rossi, Lucia; Battistelli, Cecilia; De Turris, Valeria; Noce, Valeria; Zwergel, Clemens; Valente, Sergio; Moioli, Alessandra; Manzione, Andrea; Palladino, Marco; Domenici, Alessandro; Mene', Paolo; Mai, Antonello; Tripodi, Marco; Strippoli, Raffaele - 01a Articolo in rivista
paper: OPEN ACCESS SCIENTIFIC REPORTS (Los Angeles, CA : OMICS Publishing Group, [2012]-) pp. - - issn: 2332-2675 - wos: WOS:000433547600053 (16) - scopus: 2-s2.0-85048002226 (17)
11573/1147229 - 2018 -
Effects of class II-selective histone deacetylase inhibitor on neuromuscular function and disease progression in SOD1-ALS mice Ranieri, Giuseppe Antonio; Zwergel, Clemens; Valente, Sergio; Mai, Antonello - 01a Articolo in rivista
paper: NEUROSCIENCE (Oxford: Elsevier Ltd.
Oxford; New York: Pergamon Press) pp. 228-238 - issn: 0306-4522 - wos: WOS:000430884100020 (15) - scopus: 2-s2.0-85044974964 (15)
11573/1147233 - 2018 -
Pyrazole-based inhibitors of enhancer of zeste homologue 2 induce apoptosis and autophagy in cancer cells Mellini, Paolo; Marrocco, Biagina; Polletta, Lucia; Carnevale, Ilaria; Saladini, Serena; Stazi, Giulia; Zwergel, Clemens; Ferretti, Elisabetta; Tafani, Marco; Valente, Sergio; Mai, Antonello - 01a Articolo in rivista
paper: PHILOSOPHICAL TRANSACTIONS - ROYAL SOCIETY. BIOLOGICAL SCIENCES (Royal Society of London) pp. 20170150- - issn: 0962-8436 - wos: WOS:000430738400014 (16) - scopus: 2-s2.0-85045959069 (17)
11573/1147235 - 2018 -
Trends of LSD1 inhibitors in viral infections Zwergel, Clemens; Stazi, Giulia; Mai, Antonello; Valente, Sergio - 01a Articolo in rivista
paper: FUTURE MEDICINAL CHEMISTRY (London : Future Science, 2009-.) pp. 1133-1135 - issn: 1756-8919 - wos: WOS:000433568500001 (10) - scopus: 2-s2.0-85048066484 (10)
11573/1147237 - 2018 -
Combined HAT/EZH2 modulation leads to cancer-selective cell death Valente, Sergio; Tomassi, Stefano; Sbardella, Gianluca; Mai, Antonello - 01a Articolo in rivista
paper: ONCOTARGET (Albany, N.Y. : Impact Journals) pp. 25630-25646 - issn: 1949-2553 - wos: (0) - scopus: 2-s2.0-85047400725 (6)
11573/1147239 - 2018 -
Multi-omics profiling reveals a distinctive epigenome signature for high-risk acute promyelocytic leukemia Valente, Sergio; Mai, Antonello - 01a Articolo in rivista
paper: ONCOTARGET (Albany, N.Y. : Impact Journals) pp. 25647-25660 - issn: 1949-2553 - wos: (0) - scopus: 2-s2.0-85047385574 (12)
11573/1147243 - 2018 -
Altered modulation of lamin A/C-HDAC2 interaction and p21 expression during oxidative stress response in HGPS Valente, Sergio; Mai, Antonello - 01a Articolo in rivista
paper: AGING CELL ([Oxford] : Blackwell Science Ltd, 2002-) pp. - - issn: 1474-9726 - wos: WOS:000445599100019 (28) - scopus: 2-s2.0-85052612287 (24)
11573/1147245 - 2018 -
Nucleocytoplasmic export of HDAC5 and SIRT2 downregulation: two epigenetic mechanisms by which antidepressants enhance synaptic plasticity markers Zwergel, Clemens; Cirilli, Raffaela; Mai, Antonello; Valente, Sergio - 01a Articolo in rivista
paper: PSYCHOPHARMACOLOGY (Heidelberg; Berlin: Springer) pp. 2831-2846 - issn: 0033-3158 - wos: WOS:000446140500005 (8) - scopus: 2-s2.0-85051492076 (7)
11573/1147949 - 2018 -
A quinoline-based DNA methyltransferase inhibitor as a possible adjuvant in osteosarcoma therapy Valente, Sergio; Zwergel, Clemens; Mazzone, Roberta; Stazi, Giulia; Mai, Antonello - 01a Articolo in rivista
paper: MOLECULAR CANCER THERAPEUTICS (Philadelphia, PA : American Association for Cancer Research, c2001-) pp. 1881-1892 - issn: 1535-7163 - wos: WOS:000444041300008 (23) - scopus: 2-s2.0-85053014459 (22)
11573/1174048 - 2018 -
Six years (2012-2018) of researches on catalytic EZH2 inhibitors: the boom of the 2-pyridone compounds Fioravanti, Rossella; Stazi, Giulia; Zwergel, Clemens; Valente, Sergio; Mai, Antonello - 01a Articolo in rivista
paper: THE CHEMICAL RECORD (New York N.Y.: Wiley, c2000-) pp. 1818-1832 - issn: 1527-8999 - wos: WOS:000453386600014 (59) - scopus: 2-s2.0-85055289007 (61)
11573/1202973 - 2018 -
Application of small epigenetic modulators in pediatric medulloblastoma Zwergel, Clemens; Romanelli, Annalisa; Stazi, Giulia; Besharat, Zein Mersini; Catanzaro, Giuseppina; Tafani, Marco; Valente, Sergio; Mai, Antonello - 01a Articolo in rivista
paper: FRONTIERS IN PEDIATRICS (Lausanne : Frontiers Media S.A., 2013-) pp. - - issn: 2296-2360 - wos: WOS:000452081000001 (10) - scopus: 2-s2.0-85058706178 (10)
11573/1017602 - 2017 -
EZH2 inhibitors: a patent review (2014-2016) Stazi, Giulia; Zwergel, Clemens; Mai, Antonello; Valente, Sergio - 01a Articolo in rivista
paper: EXPERT OPINION ON THERAPEUTIC PATENTS (--London United Kingdom:Informa Healthcare
-London, United Kingdom: Ashley Publications Limited) pp. 797-813 - issn: 1354-3776 - wos: WOS:000405302700004 (33) - scopus: 2-s2.0-85020639378 (33)
11573/1017610 - 2017 -
The histone methyltransferase EZH2 as a druggable target in SHH medulloblastoma cancer stem cells Miele, Evelina; Valente, Sergio; Alfano, Vincenzo; Silvano, Marianna; Mellini, Paolo; Marrocco, Biagina; Po, Agnese; Besharat, Zein Mersini; Catanzaro, Giuseppina; Battaglia, Giuseppe; Abballe, Luana; Zwergel, Clemens; Stazi, Giulia; Tafani, Marco; Mai, Antonello; Ferretti, Elisabetta - 01a Articolo in rivista
paper: ONCOTARGET (Albany, N.Y. : Impact Journals) pp. 68557-68570- - issn: 1949-2553 - wos: WOS:000410790500145 (32) - scopus: 2-s2.0-85040235337 (33)
11573/1092479 - 2017 -
Effect of Class II HDAC inhibition on glutamate transporter expression and survival in SOD1-ALS mice Zwergel, Clemens; Valente, Sergio; Mai, Antonello - 01a Articolo in rivista
paper: NEUROSCIENCE LETTERS (Elsevier Science Ireland Limited:PO Box 85, Limerick Ireland:011 353 61 709600, 011 353 61 61944, EMAIL: usinfo-f@elsevier.com, INTERNET: http://www.elsevier.com, Fax: 011 353 61 709114) pp. 120-125 - issn: 0304-3940 - wos: WOS:000409288600019 (16) - scopus: 2-s2.0-85026360880 (18)
11573/1192249 - 2017 -
Structure-activity relationships on cynnamoyl derivatives as inhibitors of p300 Histone acetyltransferase Madia, Valentina Noemi; Pescatori, Luca; Messore, Antonella; Pupo, Giovanni; Saccoliti, Francesco; Valente, Sergio; Mai, Antonello; Scipione, Luigi; Di Santo, Roberto; Costi, Roberta - 01a Articolo in rivista
paper: CHEMMEDCHEM (Weinheim : Wiley-VCH-Verl..) pp. 1359-1368 - issn: 1860-7187 - wos: WOS:000429592300014 (9) - scopus: 2-s2.0-85017448829 (8)
11573/955887 - 2017 -
Novel coumarin- and quinolinone-based polycycles as cell division cycle 25-A and -C phosphatases inhibitors induce proliferation arrest and apoptosis in cancer cells Zwergel, Clemens; Stazi, Giulia; Mori, Mattia; Patsilinakos, Alexandros; Mai, Antonello; Botta, Bruno; Ragno, Rino; Kirsch, Gilbert; Valente, Sergio - 01a Articolo in rivista
paper: EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY (Editions Scientifique & Medical Elsevier:23 Rue Linois, F 75724 Paris Cedex 15 France:011 33 1 71724646, INTERNET: http://www.elsevier.fr, Fax: 011 33 1 71724664) pp. 316-333 - issn: 0223-5234 - wos: WOS:000401677500027 (18) - scopus: 2-s2.0-85017548581 (19)
11573/972511 - 2017 -
Epi-drugs in combination with immunotherapy: a new avenue to improve anticancer efficacy Mazzone, Roberta; Zwergel, Clemens; Mai, Antonello; Valente, Sergio - 01a Articolo in rivista
paper: CLINICAL EPIGENETICS (Berlin : Springer) pp. 1-15 - issn: 1868-7083 - wos: WOS:000403112500004 (101) - scopus: 2-s2.0-85020006586 (102)
11573/851423 - 2016 -
Histone deacetylase inhibitors restore IL-10 expression in lipopolysaccharide-induced cell inflammation and reduce IL-1β and IL-6 production in breast silicone implant in C57BL/6J wild-type murine model Valente, Sergio; Taurone, Samanta; Zwergel, Clemens; Marrocco, Biagina; Turchetta, Rosaria; Mai, Antonello; Artico, Marco - 01a Articolo in rivista
paper: AUTOIMMUNITY (Amsterdam; New York: Harwood Academic Publishers.) pp. 1-11 - issn: 0891-6934 - wos: (0) - scopus: 2-s2.0-84955134169 (18)
11573/856751 - 2016 -
Discovery of a novel inhibitor of histone lysine-specific demethylase 1A (KDM1A/LSD1) as orally active antitumor agent Mai, Antonello; Marrocco, Biagina; Stazi, Giulia; Valente, Sergio - 01a Articolo in rivista
paper: JOURNAL OF MEDICINAL CHEMISTRY (Washington, DC: American Chemical Society) pp. 1501-1517 - issn: 0022-2623 - wos: WOS:000371103600018 (56) - scopus: 2-s2.0-84959421233 (58)
11573/870518 - 2016 -
LSD1 inhibitors: a patent review (2010-2015) Stazi, Giulia; Zwergel, Clemens; Valente, Sergio; Mai, Antonello - 01a Articolo in rivista
paper: EXPERT OPINION ON THERAPEUTIC PATENTS (--London United Kingdom:Informa Healthcare
-London, United Kingdom: Ashley Publications Limited) pp. 565-580 - issn: 1354-3776 - wos: WOS:000374900000003 (42) - scopus: 2-s2.0-84961644830 (43)
11573/870523 - 2016 -
1,4-Dihydropyridines Active on the SIRT1/AMPK Pathway Ameliorate Skin Repair and Mitochondrial Function and Exhibit Inhibition of Proliferation in Cancer Cells Valente, Sergio; Mellini, Paolo; Spallotta, Francesco; Polletta, Lucia; Carnevale, Ilaria; Saladini, Serena; Gabellini, Chiara; Tardugno, Maria; Zwergel, Clemens; Cencioni, Chiara; Tafani, Marco; Mai, Antonello - 01a Articolo in rivista
paper: JOURNAL OF MEDICINAL CHEMISTRY (Washington, DC: American Chemical Society) pp. 1471-1491 - issn: 0022-2623 - wos: WOS:000371103600016 (46) - scopus: 2-s2.0-84959335947 (50)
11573/870553 - 2016 -
DNA methyltransferases Inhibitors from natural sources Zwergel, Clemens; Valente, Sergio; Mai, Antonello - 01a Articolo in rivista
paper: CURRENT TOPICS IN MEDICINAL CHEMISTRY (Hilversum : Bentham Science Publishers) pp. 680-696 - issn: 1568-0266 - wos: WOS:000364586000004 (40) - scopus: 2-s2.0-84983215072 (45)
11573/931824 - 2016 -
MC1568 inhibits HDAC6/8 activity and influenza A virus replication in lung epithelial cells: Role of Hsp90 acetylation Panella, Simona; Marcocci, Maria Elena; Celestino, Ignacio; Valente, Sergio; Zwergel, Clemens; Nencioni, Lucia; Mai, Antonello; Palamara, Anna Teresa; Simonetti, Giovanna - 01a Articolo in rivista
paper: FUTURE MEDICINAL CHEMISTRY (London : Future Science, 2009-.) pp. 2017-2031 - issn: 1756-8919 - wos: WOS:000386339500004 (23) - scopus: 2-s2.0-84994010342 (25)
11573/1667577 - 2015 -
PTPS-03EPIGENETIC SILENCING OF β-ARRESTIN1 AND ITS INTRAGENIC miR-326 CONTROLS MEDULLOBLASTOMA GROWTH Miele, Evelina; Po, Agnese; Valente, Sergio; Screpanti, Isabella; Giangaspero, Felice; Levrero, Massimo; Ferretti, Elisabetta - 01h Abstract in rivista
paper: NEURO-ONCOLOGY (First or current publisher Charlottesville, VA : Carden Jennings Pub., [1999-
Intervening publisher Durham, NC : Duke University Press
Current or last publisher Oxford, UK : Oxford University Press) pp. - - issn: 1523-5866 - wos: (0) - scopus: (0)
11573/779609 - 2015 -
Pyrrole- and indole-containing tranylcypromine derivatives as novel lysine-specific demethylase 1 inhibitors active on cancer cells. Valente, Sergio; Rotili, Dante; Stazi, Giulia; Lucidi, Alessia; Mai, Antonello - 01a Articolo in rivista
paper: MEDCHEMCOMM (Cambridge : Royal Society of Chemistry, 2010-) pp. 665-670 - issn: 2040-2503 - wos: WOS:000352903400023 (22) - scopus: 2-s2.0-84928004801 (22)
11573/781693 - 2015 -
Pure enantiomers of benzoylamino-tranylcypromine: LSD1 inhibition, gene modulation in human leukemia cells and effects on clonogenic potential of murine promyelocytic blasts Valente, Sergio; Rodriguez Aedo, Verónica Alejandra; Labella, Donatella; Marrocco, Biagina; Ruoppolo, Giovanni; Mattevi, Andrea; Mai, Antonello - 01a Articolo in rivista
paper: EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY (Editions Scientifique & Medical Elsevier:23 Rue Linois, F 75724 Paris Cedex 15 France:011 33 1 71724646, INTERNET: http://www.elsevier.fr, Fax: 011 33 1 71724664) pp. 163-174 - issn: 0223-5234 - wos: WOS:000353730900016 (27) - scopus: 2-s2.0-84924406877 (28)
11573/781696 - 2015 -
Pure diastereomers of a tranylcypromine-based LSD1 inhibitor: enzyme selectivity and in-cell studies Valente, Sergio; Labella, Donatella; Marrocco, Biagina; Ruoppolo, Giovanni; Mai, Antonello - 01a Articolo in rivista
paper: ACS MEDICINAL CHEMISTRY LETTERS (USA: ACS Publications) pp. 173-177 - issn: 1948-5875 - wos: WOS:000349652000012 (20) - scopus: 2-s2.0-84922867052 (17)
11573/784164 - 2015 -
Interplay among nucleosomal DNA, histone tails, and corepressor CoREST underlies LSD1-mediated H3 demethylation Valente, Sergio; Mai, Antonello - 01a Articolo in rivista
paper: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (National Academy of Sciences:2101 Constitution Avenue Northwest:Washington, DC 20418:(877)314-2253, (615)377-3322, EMAIL: subspnas@nas.edu, INTERNET: http://www.pnas.org, Fax: (615)377-0525) pp. 2752-2757 - issn: 0027-8424 - wos: WOS:000350224900048 (58) - scopus: 2-s2.0-84924368105 (62)
11573/784167 - 2015 -
Novel histone deacetylase inhibitors induce growth arrest, apoptosis, and differentiation in sarcoma cancer stem cells Rotili, Dante; Valente, Sergio; Zwergel, Clemens; Mai, Antonello - 01a Articolo in rivista
paper: JOURNAL OF MEDICINAL CHEMISTRY (Washington, DC: American Chemical Society) pp. 4073-4079 - issn: 0022-2623 - wos: WOS:000354911200031 (50) - scopus: 2-s2.0-84929378676 (47)
11573/856754 - 2015 -
Discovery of inhibitors for the ether lipid-generating enzyme AGPS as anti-cancer agents Valente, Sergio; Marrocco, Biagina; Mai, Antonello - 01a Articolo in rivista
paper: ACS CHEMICAL BIOLOGY (AMERICAN CHEMICAL SOCiety, 1155 16TH ST, NW, WASHINGTON, USA, DC, 20036) pp. 2589-2597 - issn: 1554-8929 - wos: WOS:000365462700020 (46) - scopus: 2-s2.0-84947909618 (45)
11573/870535 - 2015 -
Emerging approaches for histone deacetylase inhibitor drug discovery Zwergel, Clemens; Valente, Sergio; Mai, Antonello - 01a Articolo in rivista
paper: EXPERT OPINION ON DRUG DISCOVERY (--London United Kingdom:Informa Healthcare
-London : Informa Healthcare, 2006-.) pp. 599-613 - issn: 1746-0441 - wos: WOS:000355006600004 (54) - scopus: 2-s2.0-84929928202 (55)
11573/870559 - 2015 -
Abstract 2946: Effects of two novel quinoline-based non-nucleoside DNA methyltransferase inhibitors against bone sarcomas Valente, Sergio; Zwergel, Clemens; Mai, Antonello - 04d Abstract in atti di convegno
paper: CANCER RESEARCH (American Association of Cancer Research:150 South Independence Mall West, #826:Philadelphia, PA 19106:(215)440-9300, EMAIL: pubs@aacr.org, INTERNET: http://www.aacr.org, Fax: (215)440-7228) pp. 2946-2946 - issn: 0008-5472 - wos: WOS:000371578506091 (0) - scopus: (0)
11573/884185 - 2015 -
Chronic stress and antidepressant induced changes in Hdac5 and Sirt2 affect synaptic plasticity Mai, Antonello; Valente, Sergio - 01a Articolo in rivista
paper: EUROPEAN NEUROPSYCHOPHARMACOLOGY (Elsevier BV:PO Box 211, 1000 AE Amsterdam Netherlands:011 31 20 4853757, 011 31 20 4853642, 011 31 20 4853641, EMAIL: nlinfo-f@elsevier.nl, INTERNET: http://www.elsevier.nl, Fax: 011 31 20 4853598) pp. 2036-2048 - issn: 0924-977X - wos: WOS:000369152500020 (41) - scopus: 2-s2.0-84947494371 (43)
11573/884188 - 2015 -
Targeting lysine deacetylases (KDACs) in parasites Valente, Sergio; Rotili, Dante; Mai, Antonello - 01a Articolo in rivista
paper: PLOS NEGLECTED TROPICAL DISEASES (San Francisco, CA : Public Library of Science) pp. e000426- - issn: 1935-2727 - wos: WOS:000363031200020 (34) - scopus: 2-s2.0-84943193825 (37)
11573/884225 - 2015 -
New insights on the mechanism of quinoline-based DNA methyltransferase inhibitors Valente, Sergio; Mai, Antonello - 01a Articolo in rivista
paper: THE JOURNAL OF BIOLOGICAL CHEMISTRY (American Society for Biochemistry and Molecular Biology:9650 Rockville Pike:Bethesda, MD 20814:(301)530-7145, EMAIL: asbmb@asbmb.faseb.org, INTERNET: http://www.faseb.org/asbmb, Fax: (301)571-1824) pp. 6293-6302 - issn: 0021-9258 - wos: WOS:000350732500035 (41) - scopus: 2-s2.0-84924897991 (46)
11573/1155213 - 2014 -
Sirtuins blunt reactive gliosis in an in vitro model of Alzheimer’s disease. Bronzuoli, Maria Rosanna; Scuderi, Caterina; Stecca, Claudia; Rotili, Dante; Valente, Sergio; Mai, Antonello; Steardo, Luca - 04d Abstract in atti di convegno
conference: 17° Simposio SIF Dottorandi, Assegnisti di Ricerca Postdottorandi e Specializzandi in Farmacologia e Scienze Affini (Rimini)
book: 17° Simposio SIF Dottorandi, Assegnisti di Ricerca Postdottorandi e Specializzandi in Farmacologia e Scienze Affini. - ()
11573/542432 - 2014 -
Pan-histone demethylase inhibitors simultaneously targeting Jumonji C and lysine-specific demethylases display high anticancer activities Rotili, Dante; Valente, Sergio; Marrocco, Biagina; Labella, Donatella; Mai, Antonello - 01a Articolo in rivista
paper: JOURNAL OF MEDICINAL CHEMISTRY (Washington, DC: American Chemical Society) pp. 42-55 - issn: 0022-2623 - wos: WOS:000329677800004 (88) - scopus: 2-s2.0-84892565144 (96)
11573/547528 - 2014 -
Selective Non-nucleoside Inhibitors of Human DNA Methyltransferases Active in Cancer Including in Cancer Stem Cells Valente, Sergio; Zwergel, Clemens; Miele, Evelina; Ferretti, Elisabetta; Gulino, Alberto; Mai, Antonello - 01a Articolo in rivista
paper: JOURNAL OF MEDICINAL CHEMISTRY (Washington, DC: American Chemical Society) pp. 701-713 - issn: 0022-2623 - wos: WOS:000331493000013 (84) - scopus: 2-s2.0-84894065301 (90)
11573/556419 - 2014 -
Context-Selective Death of Acute Myeloid Leukemia Cells Triggered by the Novel Hybrid Retinoid-HDAC Inhibitor MC2392. Rotili, Dante; Valente, Sergio; Mai, Antonello - 01a Articolo in rivista
paper: CANCER RESEARCH (American Association of Cancer Research:150 South Independence Mall West, #826:Philadelphia, PA 19106:(215)440-9300, EMAIL: pubs@aacr.org, INTERNET: http://www.aacr.org, Fax: (215)440-7228) pp. 2328-2339 - issn: 0008-5472 - wos: WOS:000334584200020 (29) - scopus: 2-s2.0-84899541163 (33)
11573/557642 - 2014 -
Reversible acetylation regulates vascular endothelial growth factor receptor-2 activity Mai, Antonello; Valente, Sergio - 01a Articolo in rivista
paper: JOURNAL OF MOLECULAR CELL BIOLOGY (Shanghai : Journal of Molecular Cell Biology Editorial Office Oxford University Press) pp. 116-127 - issn: 1674-2788 - wos: WOS:000336081100003 (24) - scopus: 2-s2.0-84899675551 (27)
11573/557645 - 2014 -
Pharmacological inhibition of EZH2 as a promising differentiation therapy in embryonal RMS De Salvo, Maria; Screpanti, Isabella; Valente, Sergio; Mai, Antonello; Locatelli, Franco - 01a Articolo in rivista
paper: BMC CANCER (BIOMED CENTRAL LTD, MIDDLESEX HOUSE, 34-42 CLEVELAND ST, LONDON, ENGLAND, W1T 4LB) pp. 139- - issn: 1471-2407 - wos: WOS:000332528100001 (44) - scopus: 2-s2.0-84898597003 (50)
11573/643824 - 2014 -
Sirtuin modulators control reactive gliosis in an in vitro model of alzheimer's disease Scuderi, Caterina; Stecca, Claudia; Bronzuoli, Maria Rosanna; Rotili, Dante; Valente, Sergio; Mai, Antonello; Steardo, Luca - 01a Articolo in rivista
paper: FRONTIERS IN PHARMACOLOGY (Lausanne: Frontiers Media S.A., 2010-) pp. - - issn: 1663-9812 - wos: WOS:000347086800001 (47) - scopus: 2-s2.0-84904631078 (51)
11573/664039 - 2014 -
Evaluation of ∆2-pioglitazone, an analogue of pioglitazone, on colon cancer cell survival: Evidence of drug treatment association with autophagy and activation of the Nrf2/Keap1 pathway Valente, Sergio - 01a Articolo in rivista
paper: INTERNATIONAL JOURNAL OF ONCOLOGY (National Hellenic Research Foundation:48 Vas Constatinou Avenue, Athens 11635 Greece:011 30 1 7241505, Fax: 011 30 1 7241505Editore attuale:PROFESSOR D A SPANDIDOS, 1, S MERKOURI ST, EDITORIAL OFFICE,, ATHENS, GREECE, 116 35.
Editore precedente:Editorial Academy of the International Journal of Oncology.) pp. 426-438 - issn: 1019-6439 - wos: WOS:000336881600046 (11) - scopus: 2-s2.0-84902598036 (11)
11573/664047 - 2014 -
Small-molecule inhibitors of histone deacetylase for the treatment of cancer and non-cancer diseases: a patent review (2011 - 2013). Valente, Sergio; Mai, Antonello - 01a Articolo in rivista
paper: EXPERT OPINION ON THERAPEUTIC PATENTS (--London United Kingdom:Informa Healthcare
-London, United Kingdom: Ashley Publications Limited) pp. 401-415 - issn: 1354-3776 - wos: WOS:000333098200003 (38) - scopus: 2-s2.0-84896470334 (39)
11573/664054 - 2014 -
PRMT1 arginine methyltransferase accumulates in cytoplasmic bodies that respond to selective inhibition and DNA damage Valente, Sergio; Labella, Donatella; Mai, Antonello - 01a Articolo in rivista
paper: EUROPEAN JOURNAL OF HISTOCHEMISTRY (Pavia : PagePress Publications, 2010) pp. 139-151 - issn: 2038-8306 - wos: WOS:000338624700013 (10) - scopus: 2-s2.0-84899705373 (9)
11573/664060 - 2014 -
1,3,4-Oxadiazole-Containing Histone Deacetylase Inhibitors: Anticancer Activities in Cancer Cells Valente, Sergio; Labella, Donatella; Lenoci, Alessia ; Mai, Antonello - 01a Articolo in rivista
paper: JOURNAL OF MEDICINAL CHEMISTRY (Washington, DC: American Chemical Society) pp. 6259-6265 - issn: 0022-2623 - wos: WOS:000339540800033 (90) - scopus: 2-s2.0-84904962606 (95)
11573/665415 - 2014 -
Novel inhibitors of human histone deacetylases: Design, synthesis and bioactivity of 3-alkenoylcoumarines Zwergel, Clemens; Mai, Antonello; Valente, Sergio - 01a Articolo in rivista
paper: BIOORGANIC & MEDICINAL CHEMISTRY LETTERS (Elsevier Science Limited:Oxford Fulfillment Center, PO Box 800, Kidlington Oxford OX5 1DX United Kingdom:011 44 1865 843000, 011 44 1865 843699, EMAIL: asianfo@elsevier.com, tcb@elsevier.co.UK, INTERNET: http://www.elsevier.com, http://www.elsevier.com/locate/shpsa/, Fax: 011 44 1865 843010) pp. 3797-3801 - issn: 0960-894X - wos: WOS:000340565900024 (39) - scopus: 2-s2.0-84905916821 (43)
11573/665612 - 2014 -
Synthesis, biological activity and mechanistic insights of 1-substituted cyclopropylamine derivatives: A novel class of irreversible inhibitors of histone demethylase KDM1A Mai, Antonello; Valente, Sergio - 01a Articolo in rivista
paper: EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY (Editions Scientifique & Medical Elsevier:23 Rue Linois, F 75724 Paris Cedex 15 France:011 33 1 71724646, INTERNET: http://www.elsevier.fr, Fax: 011 33 1 71724664) pp. 352-363 - issn: 0223-5234 - wos: WOS:000343781800032 (45) - scopus: 2-s2.0-84906839626 (44)
11573/665613 - 2014 -
Sirtuin modulators: an updated patent review (2012 - 2014) Valente, Sergio; Mai, Antonello - 01a Articolo in rivista
paper: EXPERT OPINION ON THERAPEUTIC PATENTS (--London United Kingdom:Informa Healthcare
-London, United Kingdom: Ashley Publications Limited) pp. 5-15 - issn: 1354-3776 - wos: WOS:000346742700002 (43) - scopus: 2-s2.0-84919458504 (44)
11573/670458 - 2014 -
The Polycomb group (PcG) protein EZH2 supports the survival of PAX3-FOXO1 alveolar rhabdomyosarcoma by repressing FBXO32 (Atrogin1/MAFbx) De Salvo, Maria; Adesso, Laura; Alaggio, Rita; Screpanti, Isabella; Valente, Sergio; Mai, Antonello; Locatelli, Franco - 01a Articolo in rivista
paper: ONCOGENE (Macmillan Magazines Limited:Porters South Crinian Street, London N1 9XW United Kingdom:011 44 207 8334000, 011 44 171 8434982, Fax: 011 44 207 812358) pp. 4173-4184 - issn: 0950-9232 - wos: WOS:000340595700008 (52) - scopus: 2-s2.0-84905868284 (57)
11573/799567 - 2014 -
Chalcone-Coumarin derivatives as potential anti-cancer drugs: an in vitro and in vivo investigation Valente, Sergio - 01a Articolo in rivista
paper: ANTI-CANCER AGENTS IN MEDICINAL CHEMISTRY (Bussum : Bentham Science Publishers) pp. 963-974 - issn: 1875-5992 - wos: WOS:000341884600006 (26) - scopus: 2-s2.0-84905639421 (29)
11573/513467 - 2013 -
Inhibition of Class I Histone Deacetylases Unveils a Mitochondrial Signature and Enhances Oxidative Metabolism in Skeletal Muscle and Adipose Tissue. Rotili, Dante; Valente, Sergio; Mai, Antonello - 01a Articolo in rivista
paper: DIABETES (American Diabetes Association:National Service Center, 1701 North Beaureguard Street:Alexandria, VA 22311:(800)232-3472, (703)549-1500, INTERNET: http://www.diabetes.org/diabetscare, Fax: (703)549-6995) pp. 732-742 - issn: 0012-1797 - wos: WOS:000315556400017 (168) - scopus: 2-s2.0-84869106554 (176)
11573/513468 - 2013 -
Class II HDAC Inhibition Hampers Hepatic Stellate Cell Activation by Induction of MicroRNA-29 Valente, Sergio; Mai, Antonello - 01a Articolo in rivista
paper: PLOS ONE (San Francisco, CA : Public Library of Science) pp. e55786- - issn: 1932-6203 - wos: WOS:000314610600159 (52) - scopus: 2-s2.0-84873122711 (57)
11573/513469 - 2013 -
A Nitric Oxide-dependent Crosstalk Between Class I and III Histone Deacetylases Accelerates Skin Repair. Spallotta, Francesco; Valente, Sergio; Mai, Antonello - 01a Articolo in rivista
paper: THE JOURNAL OF BIOLOGICAL CHEMISTRY (American Society for Biochemistry and Molecular Biology:9650 Rockville Pike:Bethesda, MD 20814:(301)530-7145, EMAIL: asbmb@asbmb.faseb.org, INTERNET: http://www.faseb.org/asbmb, Fax: (301)571-1824) pp. - - issn: 0021-9258 - wos: WOS:000317915500007 (59) - scopus: 2-s2.0-84876580701 (62)
11573/514588 - 2013 -
tert-Butylcarbamate-Containing Histone Deacetylase Inhibitors: Apoptosis Induction, Cytodifferentiation, and Antiproliferative Activities in Cancer Cells. Valente, Sergio; Labella, Donatella; Secci, Daniela; Mai, Antonello - 01a Articolo in rivista
paper: CHEMMEDCHEM (Weinheim : Wiley-VCH-Verl..) pp. - - issn: 1860-7179 - wos: WOS:000318245300013 (15) - scopus: 2-s2.0-84877064105 (16)
11573/525042 - 2013 -
Detrimental effect of class-selective histone deacetylase inhibitors during tissue regeneration following hindlimb ischemia Spallotta, Francesco; Mai, Antonello; Valente, Sergio; Martone, Julie; Bozzoni, Irene - 01a Articolo in rivista
paper: THE JOURNAL OF BIOLOGICAL CHEMISTRY (American Society for Biochemistry and Molecular Biology:9650 Rockville Pike:Bethesda, MD 20814:(301)530-7145, EMAIL: asbmb@asbmb.faseb.org, INTERNET: http://www.faseb.org/asbmb, Fax: (301)571-1824) pp. 22915-22929 - issn: 0021-9258 - wos: WOS:000330598200004 (27) - scopus: 2-s2.0-84881396773 (25)
11573/525043 - 2013 -
Reactivity of 4-vinyl-2H-1-benzopyran-2-ones in diels-alder cycloaddition reactions: Access to coumarin-based polycycles with Cdc25 phosphatase-inhibiting activity Valente, Sergio; Zwergel, Clemens; Mai, Antonello - 01a Articolo in rivista
paper: EUROPEAN JOURNAL OF ORGANIC CHEMISTRY (Wiley-VCH Verlag GmBH:PO Box 101161, D 69451 Weinheim Germany:011 49 6201 606147, EMAIL: service@wiley-vch.de, INTERNET: http://www.wiley-vch.de, Fax: 011 49 6201 606328) pp. 2869-2877 - issn: 1434-193X - wos: WOS:000318803200018 (10) - scopus: 2-s2.0-84877688906 (11)
11573/525990 - 2013 -
Oxidative stress and epigenetic regulation in ageing and age-related diseases Spallotta, Francesco; Valente, Sergio; Mai, Antonello - 01a Articolo in rivista
paper: INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (Basel (Matthaeustrasse 11) : Molecular Diversity Preservation International MDPI) pp. 17643-17663 - issn: 1661-6596 - wos: WOS:000328623900021 (140) - scopus: 2-s2.0-84883479431 (156)
11573/529785 - 2013 -
A novel coumarin-quinone derivative SV37 inhibits CDC25 phosphatases, impairs proliferation, and induces cell death. Valente, Sergio - 01a Articolo in rivista
paper: MOLECULAR CARCINOGENESIS (editore attuale: WILEY-LISS, DIV JOHN WILEY & SONS INC, 111 RIVER ST, HOBOKEN, USA, NJ, 07030.
editore precedente: New York, NY : Wiley-Liss.) pp. n/a-n/a - issn: 0899-1987 - wos: WOS:000347828600006 (24) - scopus: 2-s2.0-84926088320 (29)
11573/870542 - 2013 -
Novel benzofuran-chromone and -coumarin derivatives: Synthesis and biological activity in K562 human leukemia cells Zwergel, Clemens; Valente, Sergio; Mai, Antonello - 01a Articolo in rivista
paper: MEDCHEMCOMM (Cambridge : Royal Society of Chemistry, 2010-) pp. 1571-1579 - issn: 2040-2503 - wos: WOS:000327461300005 (43) - scopus: 2-s2.0-84888154287 (46)
11573/443820 - 2012 -
Coumarin polysulfides inhibit cell growth and induce apoptosis in HCT116 colon cancer cells Valente, Sergio - 01a Articolo in rivista
paper: BIOORGANIC & MEDICINAL CHEMISTRY (Oxford: Pergamon, 1993-) pp. 1584-1593 - issn: 0968-0896 - wos: WOS:000300391200024 (53) - scopus: 2-s2.0-84857033328 (55)
11573/455694 - 2012 -
Identification of PR-SET7 and EZH2 selective inhibitors inducing cell death in human leukemia U937 cells Valente, Sergio; Di Santo, Roberto; Costi, Roberta; Mai, Antonello - 01a Articolo in rivista
paper: BIOCHIMIE (Editions Scientifique & Medical Elsevier:23 Rue Linois, F 75724 Paris Cedex 15 France:011 33 1 71724646, INTERNET: http://www.elsevier.fr, Fax: 011 33 1 71724664) pp. 2308-2313 - issn: 0300-9084 - wos: WOS:000310929200011 (22) - scopus: 2-s2.0-84867395419 (26)
11573/485036 - 2012 -
Amino acid starvation induces reactivation of silenced transgenes and latent HIV-1 provirus via down-regulation of histone deacetylase 4 (HDAC4) Valente, Sergio; Mai, Antonello - 01a Articolo in rivista
paper: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (National Academy of Sciences:2101 Constitution Avenue Northwest:Washington, DC 20418:(877)314-2253, (615)377-3322, EMAIL: subspnas@nas.edu, INTERNET: http://www.pnas.org, Fax: (615)377-0525) pp. E2284-E2293 - issn: 0027-8424 - wos: WOS:000308085200011 (30) - scopus: 2-s2.0-84865194183 (32)
11573/513460 - 2012 -
Developing novel non-hydroxamate histone deacetylase inhibitors: the chelidamic warhead. Valente, Sergio; Mai, Antonello - 01a Articolo in rivista
paper: MEDCHEMCOMM (Cambridge : Royal Society of Chemistry, 2010-) pp. 298-304 - issn: 2040-2503 - wos: WOS:000301966800004 (5) - scopus: 2-s2.0-84857707526 (5)
11573/525900 - 2012 -
Aurones: Interesting Natural and Synthetic Compounds with Emerging Biological Potential Zwergel, Clemens; Valente, Sergio - 01a Articolo in rivista
paper: NATURAL PRODUCT COMMUNICATIONS (Park Lane, Westerville, Usa : Natural Product, Inc.
7963) pp. 389-394 - issn: 1934-578X - wos: WOS:000301897900022 (55) - scopus: 2-s2.0-84860770231 (55)
11573/356064 - 2011 -
Novel Cinnamyl Hydroxyamides and 2-Aminoanilides as Histone Deacetylase Inhibitors: Apoptotic Induction and Cytodifferentiation Activity Valente, Sergio; Tardugno, Maria; Ragno, Rino; Simeoni, Silvia; Tramontano, Anna; Mai, Antonello - 01a Articolo in rivista
paper: CHEMMEDCHEM (Weinheim : Wiley-VCH-Verl..) pp. 698-712 - issn: 1860-7179 - wos: WOS:000288814900016 (14) - scopus: 2-s2.0-79953046146 (14)
11573/414595 - 2011 -
Novel 3,5-bis(bromohydroxybenzylidene)piperidin-4-ones as coactivator-associated arginine methyltransferase 1 inhibitors: Enzyme selectivity and cellular activity Valente, Sergio; Di Santo, Roberto; Costi, Roberta; Mai, Antonello - 01a Articolo in rivista
paper: JOURNAL OF MEDICINAL CHEMISTRY (Washington, DC: American Chemical Society) pp. 4928-4932 - issn: 0022-2623 - wos: WOS:000292479600049 (61) - scopus: 2-s2.0-79960191524 (67)
11573/436635 - 2011 -
Novel Reversible Monoamine Oxidase A Inhibitors: Highly Potent and Selective 3-(1H-Pyrrol-3-yl)-2-oxazolidinones Valente, Sergio; Tempera, Giampiero; Saccoccio, Stefania; Agostinelli, Enzo; Mai, Antonello - 01a Articolo in rivista
paper: JOURNAL OF MEDICINAL CHEMISTRY (Washington, DC: American Chemical Society) pp. 8228-8232 - issn: 0022-2623 - wos: WOS:000297445400024 (28) - scopus: 2-s2.0-82555187393 (28)
11573/443817 - 2011 -
Application of 3 μm particle-based amylose-derived chiral stationary phases for the enantioseparation of potential histone deacetylase inhibitors. Mai, Antonello; Valente, Sergio - 01a Articolo in rivista
paper: JOURNAL OF CHROMATOGRAPHY A (Elsevier BV:PO Box 211, 1000 AE Amsterdam Netherlands:011 31 20 4853757, 011 31 20 4853642, 011 31 20 4853641, EMAIL: nlinfo-f@elsevier.nl, INTERNET: http://www.elsevier.nl, Fax: 011 31 20 4853598) pp. 8394-8398 - issn: 0021-9673 - wos: WOS:000297036000012 (17) - scopus: 2-s2.0-80054874258 (18)
11573/525044 - 2011 -
Histone deacetylase inhibitors (epigenetic alterations)Targeted Therapies for Hepatocellular Carcinoma Valente, Sergio; Mai, Antonello - 02a Capitolo o Articolo
book: Targeted Therapies for Hepatocellular Carcinoma - (9781780840628)
11573/526018 - 2011 -
Facile synthesis of 4-acetyl-coumarins, -thiocoumarin and -quinolin-2(1H)-one via very high α-regioselective Heck coupling on tosylates Valente, Sergio - 01a Articolo in rivista
paper: TETRAHEDRON LETTERS (Oxford; New York; Paris; Frankfurt: Pergamon Press, 1959-) pp. 3429-3432 - issn: 0040-4039 - wos: WOS:000292413800005 (18) - scopus: 2-s2.0-79957940869 (18)
11573/229552 - 2010 -
Nitric oxide determines mesodermic differentiation of mouse embryonic stem cells by activating class IIa histone deacetylases: potential therapeutic implications in a mouse model of hindlimb ischemia Spallotta, Francesco; Rotili, Dante; Valente, Sergio; Mai, Antonello - 01a Articolo in rivista
paper: STEM CELLS (Alphamed Press Incorporated:1 Prestige Place, Suite 290:Miamisburg, OH 45342:(937)291-2355, EMAIL: alphamedpress@alphamedpress.com, INTERNET: http://www.alphamedpress.com, Fax: (937)291-4229) pp. 431-442 - issn: 1066-5099 - wos: WOS:000277093700006 (47) - scopus: 2-s2.0-77950581254 (46)
11573/365281 - 2010 -
Biochemical, Structural, and Biological Evaluation of Tranylcypromine Derivatives as Inhibitors of Histone Demethylases LSD1 and LSD2 Valente, Sergio; Mai, Antonello - 01a Articolo in rivista
paper: JOURNAL OF THE AMERICAN CHEMICAL SOCIETY ([Washington, USA: American Chemical Society] 1879-) pp. 6827-6833 - issn: 0002-7863 - wos: WOS:000277721500044 (222) - scopus: 2-s2.0-77952355653 (235)
11573/434968 - 2010 -
TNF/p38α/polycomb signaling to Pax7 locus in satellite cells links inflammation to the epigenetic control of muscle regeneration Mozzetta, Chiara; Valente, Sergio; Mai, Antonello - 01a Articolo in rivista
paper: CELL STEM CELL (Cambridge: Cell Press (an imprint of Elsevier)) pp. 455-469 - issn: 1934-5909 - wos: WOS:000283270600008 (300) - scopus: 2-s2.0-77957357566 (319)
11573/434969 - 2010 -
HDACs class II-selective inhibition alters nuclear receptor-dependent differentiation Valente, Sergio; Rotili, Dante; Mai, Antonello - 01a Articolo in rivista
paper: JOURNAL OF MOLECULAR ENDOCRINOLOGY (Pubblicata da:
SOC ENDOCRINOLOGY, 22 APEX COURT, WOODLANDS, BRADLEY STOKE, BRISTOL, ENGLAND, BS32 4JT
primo editore:
Journal of Endocrinology Limited:17 18 Courtyard Woodlands, Bristol BS12 4NQ United Kingdom:011 44 117 9616046, EMAIL: sxa15@psu.edu, INTERNET: http://www.psu.edu, Fax: 011 44 117 9616071) pp. 219-228 - issn: 0952-5041 - wos: WOS:000282528800005 (50) - scopus: 2-s2.0-77957824326 (53)
11573/443480 - 2010 -
Synthesis and biological evaluation of novel coumarin-based inhibitors of Cdc25 phosphatases Valente, Sergio - 01a Articolo in rivista
paper: BIOORGANIC & MEDICINAL CHEMISTRY LETTERS (Elsevier Science Limited:Oxford Fulfillment Center, PO Box 800, Kidlington Oxford OX5 1DX United Kingdom:011 44 1865 843000, 011 44 1865 843699, EMAIL: asianfo@elsevier.com, tcb@elsevier.co.UK, INTERNET: http://www.elsevier.com, http://www.elsevier.com/locate/shpsa/, Fax: 011 44 1865 843010) pp. 5827-5830 - issn: 0960-894X - wos: WOS:000281735600049 (35) - scopus: 2-s2.0-77957590019 (36)
11573/895420 - 2010 -
Evaluation of histone deacetylases as drug targets in Huntington's disease models Rotili, Dante; Valente, Sergio; Mai, Antonello - 02a Capitolo o Articolo
book: PLOS CURRENTS - ()
11573/12746 - 2009 -
Pyrrole-Based Hydroxamates and 2-Aminoanilides: Histone Deacetylase Inhibition and Cellular Activities Mai, Antonello; Valente, Sergio - 01a Articolo in rivista
paper: CHEMMEDCHEM (Weinheim : Wiley-VCH-Verl..) pp. 1411-1415 - issn: 1860-7179 - wos: WOS:000270027800002 (9) - scopus: 2-s2.0-69749113873 (9)
11573/12799 - 2009 -
Study of 1,4-Dihydropyridine Structural Scaffold: Discovery of Novel Sirtuin Activators and Inhibitors Mai, Antonello; Valente, Sergio - 01a Articolo in rivista
paper: JOURNAL OF MEDICINAL CHEMISTRY (Washington, DC: American Chemical Society) pp. 5496-5504 - issn: 0022-2623 - wos: WOS:000269655500022 (133) - scopus: 2-s2.0-69949096844 (140)
11573/13427 - 2009 -
Histone post-translational modifications by HPLC-ESI-MS after HT29 cell treatment with HDAC inhibitors Valente, Sergio; Mai, Antonello - 01a Articolo in rivista
paper: PROTEOMICS (Wiley-VCH Verlag GmBH:PO Box 101161, D 69451 Weinheim Germany:011 49 6201 606147, EMAIL: service@wiley-vch.de, INTERNET: http://www.wiley-vch.de, Fax: 011 49 6201 606328) pp. 5437-5445 - issn: 1615-9853 - wos: WOS:000273515000006 (20) - scopus: 2-s2.0-73149088831 (22)
11573/229211 - 2009 -
New pyrrole-based histone deacetylase inhibitors: Binding mode, enzyme- and cell-based investigations Mai, Antonello; Valente, Sergio; Simeoni, Silvia; Ragno, Rino - 01a Articolo in rivista
paper: THE INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY (Applied Science Publishers:Ripple Road, Barking Essex United Kingdom) pp. 235-247 - issn: 1357-2725 - wos: WOS:000262620400028 (23) - scopus: 2-s2.0-55949088703 (25)
11573/229551 - 2009 -
Shock and kill" effects of class I-selective histone deacetylase inhibitors in combination with the glutathione synthesis inhibitor buthionine sulfoximine in cell line models for HIV-1 quiescence Mai, Antonello; Valente, Sergio; Rotili, Dante; Palamara, Anna Teresa - 01a Articolo in rivista
paper: RETROVIROLOGY (London : BioMed Central) pp. 52-52 - issn: 1742-4690 - wos: WOS:000267430700001 (94) - scopus: 2-s2.0-67649259174 (94)
11573/434973 - 2009 -
Selective class II HDAC inhibitors impair myogenesis by modulating the stability and activity of HDAC-MEF2 complexes. Rotili, Dante; Valente, Sergio; Mai, Antonello - 01a Articolo in rivista
paper: EMBO REPORTS (Oxford : Oxford University Press, 2000-) pp. 776-782 - issn: 1469-221X - wos: WOS:000267599700022 (112) - scopus: 2-s2.0-67650083046 (116)
11573/442678 - 2009 -
Histone deacetylase inhibitors and neurodegenerative disorders: Holding the promise Mai, Antonello; Rotili, Dante; Valente, Sergio - 01a Articolo in rivista
paper: CURRENT PHARMACEUTICAL DESIGN (Bentham Science Publishers BV:PO Box 7917, Exec Ste Y 26, Saif Zone Sharjah Uae:011 971 6 5571132, EMAIL: benthams@emirates.net.ae, INTERNET: http://www.bentham.org, Fax: 011 971 6 5571134) pp. 3940-3957 - issn: 1381-6128 - wos: WOS:000271385600003 (67) - scopus: 2-s2.0-70649108817 (66)
11573/13144 - 2008 -
HDAC-class II specific inhibition involves HDAC proteasome-dependent degradation mediated by RANBP2 Valente, Sergio; Mai, Antonello - 01a Articolo in rivista
paper: BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH (Elsevier BV:PO Box 211, 1000 AE Amsterdam Netherlands:011 31 20 4853757, 011 31 20 4853642, 011 31 20 4853641, EMAIL: nlinfo-f@elsevier.nl, INTERNET: http://www.elsevier.nl, Fax: 011 31 20 4853598) pp. 2030-2038 - issn: 0167-4889 - wos: WOS:000259917200036 (45) - scopus: 2-s2.0-50849143144 (47)
11573/13369 - 2008 -
Specific Activity of Class II Histone Deacetylases in Human Breast Cancer Cells Mai, Antonello; Valente, Sergio - 01a Articolo in rivista
paper: MOLECULAR CANCER RESEARCH (American Association of Cancer Research:150 South Independence Mall West, #826:Philadelphia, PA 19106:(215)440-9300, EMAIL: pubs@aacr.org, INTERNET: http://www.aacr.org, Fax: (215)440-7228) pp. 1908-1919 - issn: 1541-7786 - wos: WOS:000261824800011 (77) - scopus: 2-s2.0-57749101152 (85)
11573/13425 - 2008 -
Epigenetric Multiple Ligands: Mixed Histone/Protein Methyltransferase, Acetyltransferase, and Class III Deacetylase (Sirtuin) Inhibitors Mai, Antonello; Valente, Sergio; Sbardella, Gianluca - 01a Articolo in rivista
paper: JOURNAL OF MEDICINAL CHEMISTRY (Washington, DC: American Chemical Society) pp. 2279-2290 - issn: 0022-2623 - wos: WOS:000254709100033 (119) - scopus: 2-s2.0-41849146748 (125)
11573/358405 - 2008 -
Nitric oxide modulates chromatin folding in human endothelial cells via protein phosphatase 2A activation and class II histone deacetylases nuclear shuttling Spallotta, Francesco; Rotili, Dante; Valente, Sergio; Mai, Antonello - 01a Articolo in rivista
paper: CIRCULATION RESEARCH (Lippincott, Williams & Wilkins:530 Walnut Street:Philadelphia, PA 19106:(800)638-3030, (301)223-2300, EMAIL: orders@lww.com, INTERNET: http://www.lww.com, Fax: (301)223-2320, (301)223-2320
PRimo editore:
Baltimore, Md. : Grune & Stratton, c1953-) pp. 51-58 - issn: 0009-7330 - wos: WOS:000252217400009 (93) - scopus: 2-s2.0-37849010584 (97)
11573/363936 - 2008 -
Novel uracil-based 2-aminoanilide and 2-aminoanilide-like derivatives: Histone deacetylase inhibition and in-cell activities Mai, Antonello; Rotili, Dante; Valente, Sergio - 01a Articolo in rivista
paper: BIOORGANIC & MEDICINAL CHEMISTRY LETTERS (Elsevier Science Limited:Oxford Fulfillment Center, PO Box 800, Kidlington Oxford OX5 1DX United Kingdom:011 44 1865 843000, 011 44 1865 843699, EMAIL: asianfo@elsevier.com, tcb@elsevier.co.UK, INTERNET: http://www.elsevier.com, http://www.elsevier.com/locate/shpsa/, Fax: 011 44 1865 843010) pp. 2530-2535 - issn: 0960-894X - wos: WOS:000255246400002 (20) - scopus: 2-s2.0-41849089386 (24)
11573/240206 - 2007 -
Synthesis and biological validation of novel synthetic histone/protein methyltransferase inhibitors Mai, Antonello; Valente, Sergio; Ragno, Rino; Simeoni, Silvia - 01a Articolo in rivista
paper: CHEMMEDCHEM (Weinheim : Wiley-VCH-Verl..) pp. 987-991 - issn: 1860-7179 - wos: WOS:000248065600003 (51) - scopus: 2-s2.0-41849112166 (50)
11573/362130 - 2007 -
Identification of two new synthetic histone deacetylase inhibitors that modulate globin gene expression in erythroid cells from healthy donors and patients with thalassemia Mai, Antonello; Rotili, Dante; Valente, Sergio - 01a Articolo in rivista
paper: MOLECULAR PHARMACOLOGY (American Society for Pharmacology and Experimental Therapeutics:9650 Rockville Pike:Bethesda, MD 20814:(301)530-7024, EMAIL: pstoute@aspet.org, INTERNET: http://www.aspet.org, Fax: (301)634-7099) pp. 1111-1123 - issn: 0026-895X - wos: WOS:000250385300004 (29) - scopus: 2-s2.0-35548933854 (30)
11573/364545 - 2007 -
Novel pyrrole-containing histone deacetylase inhibitors endowed with cytodifferentiation activity Mai, Antonello; Valente, Sergio; Rotili, Dante - 01a Articolo in rivista
paper: THE INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY (Applied Science Publishers:Ripple Road, Barking Essex United Kingdom) pp. 1510-1522 - issn: 1357-2725 - wos: WOS:000248566700025 (14) - scopus: 2-s2.0-34447268739 (14)
11573/51660 - 2007 -
New Aroyl-Pyrrolyl-Hydroxy-Amides APHAs: Class I and II Histone Deacetylase Inhibiting Activity and Binding Mode Analysis through Molecular Docking Experiments Ragno, Rino; Mai, Antonello; Valente, Sergio - 04a Atto di comunicazione a congresso
conference: Frontiers in CNS and Oncology Medicinal Chemistry, ACS-EFMC (Siena, Italy)
book: Frontiers in CNS and Oncology Medicinal Chemistry, ACS-EFMC - ()
11573/234238 - 2006 -
Aroyl-pyrrolyl hydroxyamides: Influence of pyrrole C4-phenylacetyl substitution on histone deacetylase inhibition Mai, Antonello; Valente, Sergio; Ragno, Rino - 01a Articolo in rivista
paper: CHEMMEDCHEM (Weinheim : Wiley-VCH-Verl..) pp. 225-237 - issn: 1860-7179 - wos: WOS:000202945600008 (21) - scopus: 2-s2.0-33646483786 (22)
11573/234818 - 2006 -
3-D QSAR Studies on Histone Deacetylase Inhibitors. A GOLPE/GRID Approach on Different Series of Compounds. Ragno, Rino; Valente, Sergio; Mai, Antonello - 01a Articolo in rivista
paper: JOURNAL OF CHEMICAL INFORMATION AND MODELING (AMER CHEMICAL SOC, 1155 16TH ST, NW, WASHINGTON, USA, DC, 20036) pp. 1420-1430 - issn: 1549-9596 - wos: WOS:000237658400053 (40) - scopus: 2-s2.0-33745356936 (44)
11573/13036 - 2005 -
Synthesis and biological evaluation of 2-, 3-, and 4-acylaminocinnamyl-N-hydroxyamides as novel synthetic HDAC inhibitors. Mai, Antonello; Valente, Sergio - 01a Articolo in rivista
paper: MEDICINAL CHEMISTRY (Bentham Science Publishers Ltd) pp. 245-254 - issn: 1573-4064 - wos: (0) - scopus: 2-s2.0-25144492801 (26)
11573/365771 - 2005 -
3-(1H-Pyrrol-2-yl)-2-oxazolidinones as novel monoamine oxidase type A inhibitors. Mai, Antonello; Artico, Marino; Valente, Sergio; Sbardella, Gianluca; Turini, Paola; Befani, Olivia; Agostinelli, Enzo - 01a Articolo in rivista
paper: MEDICINAL CHEMISTRY (Bentham Science Publishers Ltd) pp. 117-124 - issn: 1573-4064 - wos: (0) - scopus: 2-s2.0-33846116762 (6)
11573/526020 - 2005 -
Histone Deacetylation in Epigenetics: An Attractive Target for Anticancer Therapy Mai, Antonello; Rotili, Dante; Valente, Sergio; Ragno, Rino - 01a Articolo in rivista
paper: MEDICINAL RESEARCH REVIEWS (John Wiley & Sons Incorporated:Customer Service, 111 River Street:Hoboken, NJ 07030:(800)225-5945, (201)748-6000, EMAIL: societyinfo@wiley.com, INTERNET: http://www.wiley.com, Fax: (212)748-6551) pp. 261-309 - issn: 0198-6325 - wos: WOS:000228224900001 (292) - scopus: 2-s2.0-16844362441 (305)
11573/13659 - 2004 -
Antimalarial and Antileishmanial Activities of Aroyl-pyrrolyl-hydroxy-amides, a New Class of Histone Deacetylase Inhibitors Mai, Antonello; Valente, Sergio - 01a Articolo in rivista
paper: ANTIMICROBIAL AGENTS AND CHEMOTHERAPY (American Society for Microbiology:PO Box 11127:Birmingham, AL 35201:(800)633-4931, (205)995-1567, EMAIL: asm.nonmembers.subs@ebsco.com, INTERNET: http://www.asm.org, Fax: (205)995-1588) pp. 1435-1436 - issn: 0066-4804 - wos: WOS:000220658600060 (49) - scopus: 2-s2.0-1642460965 (50)
11573/234811 - 2004 -
3-(4-Aroyl-1-methyl-1H-2-pyrrolyl)-N-hydroxy-2-propenamides as a New Class of Synthetic Histone Deacetylase Inhibitors. 2. Effect of Pyrrole-C2 and/or -C4 Substitutions on Biological Activity Mai, Antonello; Valente, Sergio; Ragno, Rino - 01a Articolo in rivista
paper: JOURNAL OF MEDICINAL CHEMISTRY (Washington, DC: American Chemical Society) pp. 1098-1109 - issn: 0022-2623 - wos: WOS:000189151500005 (59) - scopus: 2-s2.0-1242273835 (66)
11573/240328 - 2004 -
Synthesis and biochemical evaluation of (R)-5-acyloxymethyl- and (S)-5-acylaminomethyl-3-(1H-pyrrol-1-yl)-2-oxazolidinones as new anti-monoamine oxidase (anti-MAO) agents. Mai, Antonello; Artico, Marino; Valente, Sergio; Befani, Olivia; Turini, Paola; Agostinelli, Enzo - 01a Articolo in rivista
paper: ARKIVOC (ARKAT USA INC, C/O ALAN R KATRITZKY, UNIV FLORIDA, DEPT CHEMISTRY, PO BOX 117200, GAINESVILLE, USA, FL, 32611) pp. 23-43 - issn: 1551-7004 - wos: WOS:000222493900004 (6) - scopus: (0)
11573/434777 - 2004 -
3-(4-Aroyl-1-methyl-1H-pyrrol-2-yl)-N-hydroxy-2-propenamides as a new class of synthetic histone deacetylase inhibitors. 3. Discovery of novel lead compounds through structure-based drug design and docking studies. Ragno, Rino; Mai, Antonello; Valente, Sergio - 01a Articolo in rivista
paper: JOURNAL OF MEDICINAL CHEMISTRY (Washington, DC: American Chemical Society) pp. - - issn: 0022-2623 - wos: WOS:000220038700008 (64) - scopus: 2-s2.0-12144291023 (69)
11573/204734 - 2003 -
3-(1H-pyrrol-2- and –3-yl)-2-oxazolidinones as novel potent and selective monoamine oxidase type A inhibitors. Mai, Antonello; Valente, Sergio; Artico, Marino; Befani, Olivia; Turini, Paola; Agostinelli, Enzo - 04a Atto di comunicazione a congresso
book: 8th International Congress on Amino Acids and Proteins - ()
11573/218667 - 2003 -
3-(1H-pyrrol-2- and –3-yl)-2-oxazolidinones as novel potent and selective monoamine oxidase type A inhibitors. Mai, Antonello; Valente, Sergio; Artico, Marino; Befani, Olivia; Turini, Paola; Agostinelli, Enzo - 13a Altro ministeriale