SERGIO VALENTE

Associate professor

email: sergio.valente@uniroma1.it
phone: 0649913724
building: CU019
room: 154

Personal information
Name: Sergio Valente
Work address: Piazzale Aldo Moro 5, 00185, Rome (Italy)
Phone number (Lab): 0649913593-0649913976
Phone number (Office): 0649913724
E-mail address: sergio.valente@uniroma1.it
Education
March 2007
phD “Pasteur Science”, at Department of Drug Chemistry and Technologies, “Sapienza”, University of Rome;
March 2003
University degree in Pharmacy 110/110 cum laude at the above mentioned Department.
Reasearch experiences
From March 2020: Associate Professor in Medicinal Chemistry at Department of Drug Chemistry and Technologies, Sapienza University of Rome, Italy;
From October 2011 to March 2020: Assistant Professor in Medicinal Chemistry at Department of Drug Chemistry and Technologies, Sapienza University of Rome, Italy;
July-2009-May 2011: Post-doc position (REDCAT, Marie Curie project, [European Community's] Seventh Framework Programme [FP7/2007-2013], Grant Agreement No. 215009), LIMBP, Université de la Lorraine-Metz, France.
April 2007-June 2009: contract with Sapienza University for research activity at the Department of Drug Chemistry and Technologies, “Sapienza”, University of Rome.
Main research activity
Design, synthesis and development of small epigenetic modulators of HDACs, SIRTs, HMTs, KDMs, DNMTs) for a new approach to anticancer chemotherapy, neurodegenerative and metabolic pathologies, anti-parasitic treatment.
Abilitations
From July 2007 National Qualification for Pharmacist profession and from February 2022 National Scientific Qualification (ASN, MIUR) for Full Professor Position.
Teaching Activity (Faculty of Pharmacy and Medicine, Sapienza University of Rome, Italy).
From 2022 Holder of the course "Medicinal and Toxicological Chemistry I", III year of master degree in CTF (Latina)
From 2015 Holder of the course “Chemical-Pharmaceutical and Toxicological Analysis I”, II year of master degree in CTF; holder of the course 2012-2013, 2013-2014 and 2014-2015 “Chemical-Pharmaceutical and Toxicological Analysis”, II year of master degree in Pharmacy; holder of the course 2011-2012 “Laboratory of Extractive and Synthetic Preparation of Drugs”, V year of master degree in CTF (Pharmaceutical Chemistry and Technology; member of examination committee, also for Master Degree, integrative lectures and assistance for students; d) tutoring for graduating and PhD students in Medicinal Chemistry.
Congress Communications (oral and posters)
10 oral communications and more than 100 poster communications at National and International Congresses in Medicinal Chemistry.
Awards
Paestum (SA), 11 September 2017, National Prize for Medicinal Chemistry Research received by Medicinal Chemistry Division of Italian Chemical Society.
Technical skills and competences
Advanced and microwave-assisted organic synthesis. Molecular modelling. Windows Vista, XP 2003, 2007, 2010, Windows 7-10, ISIS Draw, Chem Bio Draw 2013, MS Office, Spectrometry analysis (1H-NMR, 13C-NMR, Mass).
Grants
▪ Project Title: “Development of novel dual-targeting epigenetic modulators for novel epi-polypharmacological cancer treatment”, AIRC Foundation 2021
Position in project: Principal Investigator.
Total financing: 342.000 Euro
▪ Project Title: “Mechanistic understanding of NADPH oxidases and their roles in ROS biology”, PRIN-MIUR 2020
Position in project: Unit’s Coordinator
Total financing: 215.574 Euro
▪ Project Title: “Design and biological evaluation of novel epigenetic dual-targeting modulators to fight cancer”, Ateneo Sapienza Project
Position in project: Principal Investigator
Total financing: 48000 Euro
▪ Project Title: “Design, synthesis, anticancer evaluation of novel irreversible as well as reversible LSD1 inhibitors and development of probes for chemoproteomics of LSD1”, Ateneo Sapienza Project
Position in project: Principal Investigator
Total financing: 8000 Euro
▪ Project Title: “Anti-Parasitic Drug Discovery in Epigenetics”, European Community, European Project EC-GA N°602080; WORK PACKAGE 4, 6, 7-A-PARADDISE
Position in project: Collaborator
Total financing: 284016 Euro
▪ Project Title: “Enhancer of Zeste Homolog 2 inhibitors: a novel strategy anticancer therapy”, Ateneo Sapienza Project
Position in project: Collaborator
Total financing: 15000 Euro
▪ Project Title: “Regolazione dell'espressione di citochine infiammatorie nel tessuto periprotesico di protesi mammarie siliconiche mediante impiego di inibitori delle istone deacetilasi in un modello sperimentale murino”, Ateneo Sapienza Project
Position in project: Collaborator.
Total financing: 33946 Euro
▪ Project Title: “Novel Probes for Sirtuin Enzymes: a Medicinal Chemistry/Chemical Biology Approach”, Ateneo Sapienza Project
Position in project: Collaborator.
Total financing: 40000 Euro
▪ Project Title: “A BLUEPRINT of Haematopoietic Epigenomes”; European Community, European Project N° 282520; WORK PACKAGE 15, BLUEPRINT
Position in project: Collaborator.
Total financing: 242379.6 Euro

Reviewer activity
Journal of Medicinal Chemistry, European Journal of Medicinal Chemistry, Current Topics in Medicinal Chemistry, Expert Opinion on Drug Discovery, Expert Opinion on Therapeutics Patents, Pharmacological Research, Frontiers in Pharmacology, Autophagy, Oxidative Medicine and Cellular Longevity, Aging and Disease, Scientific Reports, Autophagy, Tetrahedron Letters.
Scientific Publications
Author/Co-Author of 147 scientific papers; H-Index: 44, total citations: 5553.

Research products

11573/1658358 - 2023 - Chemically diverse S. mansoni HDAC8 inhibitors reduced viability in worm larval and adult stages
Noce, Beatrice; Di Bello, Elisabetta; Zwergel, Clemens; Fioravanti, Rossella; Valente, Sergio; Rotili, Dante; Ansari, Mohammad Salik Zeya; Trisciuoglio, Daniela; Mai, Antonello - 01a Articolo in rivista
paper: CHEMMEDCHEM (Weinheim : Wiley-VCH-Verl..) pp. - - issn: 1860-7179 - wos: WOS:000879912800001 (0) - scopus: 2-s2.0-85141693563 (0)

11573/1662777 - 2023 - Novel pyridine-containing histone deacetylase inhibitors strongly arrest proliferation, induce apoptosis and modulate miRNAs in cancer cells
Di Bello, Elisabetta; Bontempi, Giulio; Zwergel, Clemens; Fioravanti, Rossella; Noce, Beatrice; Castiello, Carola; Corinti, Davide; Tripodi, Marco; Strippoli, Raffaele; Valente, Sergio; Mai, Antonello - 01a Articolo in rivista
paper: EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY (Editions Scientifique & Medical Elsevier:23 Rue Linois, F 75724 Paris Cedex 15 France:011 33 1 71724646, INTERNET: http://www.elsevier.fr, Fax: 011 33 1 71724664) pp. 115022- - issn: 0223-5234 - wos: WOS:000911596400001 (0) - scopus: 2-s2.0-85144323384 (0)

11573/1669899 - 2023 - METTL3 from Target Validation to the First Small-Molecule Inhibitors: A Medicinal Chemistry Journey
Fiorentino, Francesco; Menna, Martina; Rotili, Dante; Valente, Sergio; Mai, Antonello - 01g Articolo di rassegna (Review)
paper: JOURNAL OF MEDICINAL CHEMISTRY (Washington DC : ACS Publications) pp. 1654-1677 - issn: 1520-4804 - wos: (0) - scopus: 2-s2.0-85147012551 (0)

11573/1673946 - 2023 - Role of SIRT3 in Microgravity Response: A New Player in Muscle Tissue Recovery
Aventaggiato, Michele; Barreca, Federica; Valente, Sergio; Rotili, Dante; Mai, Antonello; Lotti, Lavinia Vittoria; Sansone, Luigi; Russo, Matteo Antonio; Bizzarri, Mariano; Ferretti, Elisabetta; Tafani, Marco - 01a Articolo in rivista
paper: CELLS (Basel: mdpi-Molecular Diversity Preservation International) pp. 691- - issn: 2073-4409 - wos: (0) - scopus: (0)

11573/1674091 - 2023 - GreenMedChem- the challenge in the next decade toward eco-friendly compounds and processes in drug design
Castiello, Carola; Valente, Sergio; Rotili, Dante; Fioravanti, Rossella; Zwergel, Clemens; Mai, Antonello - 01g Articolo di rassegna (Review)
paper: GREEN CHEMISTRY (Royal Society of Chemistry:Thomas Graham House, Science Park, Cambridge CB4 0WF United Kingdom:011 44 1223 432360, EMAIL: sales@rsc.org, INTERNET: http://www.rsc.org, http://www.chensoc.org, Fax: 011 44 1223 423429) pp. 2109-2169 - issn: 1463-9262 - wos: (0) - scopus: (0)

11573/1612791 - 2022 - Inhibition of PKCθ Improves Dystrophic Heart Phenotype and Function in a Novel Model of DMD Cardiomyopathy
Morroni, Jacopo; Schirone, Leonardo; Zwergel, Clemens; Sanchez Riera, Carles; Valente, Sergio; Vecchio, Daniele; Schiavon, Sonia; Ragno, Rino; Mai, Antonello; Sciarretta, Sebastiano; Lozanoska Ochser, Biliana; Bouche', Marina - 01a Articolo in rivista
paper: INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (Basel: MDPI Center) pp. 1-16 - issn: 1422-0067 - wos: WOS:000772462700001 (0) - scopus: 2-s2.0-85124895071 (0)

11573/1614439 - 2022 - Cytoplasmic HDAC4 regulates the membrane repair mechanism in Duchenne muscular dystrophy
Renzini, Alessandra; Marroncelli, Nicoletta; Cavioli, Giorgia; Di Francescantonio, Silvia; Forcina, Laura; Valente, Sergio; Mai, Antonello; Giampietri, Claudia; Magenta, Alessandra; De Santa, Francesca; Adamo, Sergio; Coletti, Dario; Moresi, Viviana - 01a Articolo in rivista
paper: JOURNAL OF CACHEXIA, SARCOPENIA AND MUSCLE (Heidelberg ; Berlin : Springer) pp. 1339-1359 - issn: 2190-5991 - wos: WOS:000755498900001 (6) - scopus: 2-s2.0-85124595217 (6)

11573/1623442 - 2022 - Targeting the anti-apoptotic Bcl-2 family proteins: Machine learning virtual screening and biological evaluation of new small molecules
Montesano, Camilla; Patsilinakos, Alexandros; Sabatino, Manuela; Antonini, Lorenzo; Valente, Sergio; Mai, Antonello; Colotti, Gianni; Ragno, Rino - 01a Articolo in rivista
paper: THERANOSTICS (Wyoming, N.S.W. : Ivyspring International Publisher, 2011-) pp. 2427-2444 - issn: 1838-7640 - wos: WOS:000766737800003 (1) - scopus: 2-s2.0-85126080507 (0)

11573/1623778 - 2022 - Heterocycle-containing tranylcypromine derivatives endowed with high anti-LSD1 activity
Fioravanti, Rossella; Di Bello, Elisabetta; Noce, Beatrice; Zwergel, Clemens; Corinti, Davide; Valente, Sergio; Mai, Antonello - 01a Articolo in rivista
paper: JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY (Taylor & Francis Limited:Rankine Road, Basingstoke RG24 8PR United Kingdom:011 44 1256 813035, EMAIL: madeline.sims@tandf.co.uk, info@tandf.co.uk, INTERNET: http://www.tandf.co.uk, Fax: 011 44 1256 330245) pp. 973-985 - issn: 1475-6366 - wos: WOS:000771778600001 (0) - scopus: 2-s2.0-85126852334 (0)

11573/1650772 - 2022 - Effects of Structurally Different HDAC Inhibitors against Trypanosoma cruzi, Leishmania, and Schistosoma mansoni
Di Bello, Elisabetta; Noce, Beatrice; Fioravanti, Rossella; Zwergel, Clemens; Valente, Sergio; Rotili, Dante; Mai, Antonello - 01a Articolo in rivista
paper: ACS INFECTIOUS DISEASES (Washington, DC : American Chemical Society, 2015-) pp. 1356-1366-1366 - issn: 2373-8227 - wos: WOS:000819851400001 (7) - scopus: 2-s2.0-85134360722 (7)

11573/1657657 - 2022 - Potent and Specific Activators for Mitochondrial Sirtuins Sirt3 and Sirt5
Valente, Sergio; Zwergel, Clemens; Di Bello, Elisabetta; Fioravanti, Rossella; Aventaggiato, Michele; Tafani, Marco; Mai, Antonello - 01a Articolo in rivista
paper: JOURNAL OF MEDICINAL CHEMISTRY (Washington, DC: American Chemical Society) pp. 14015-14031 - issn: 0022-2623 - wos: WOS:000878509000001 (0) - scopus: 2-s2.0-85140303478 (0)

11573/1659806 - 2022 - Restoration of WT1/miR-769-5p axis by HDAC1 inhibition promotes MMT reversal in mesenchymal-like mesothelial cells
Bontempi, Giulio; Terri, Michela; Garbo, Sabrina; Montaldo, Claudia; Valente, Sergio; Zwergel, Clemens; Mai, Antonello; Marchetti, Alessandra; Mene', Paolo; Battistelli, Cecilia; Tripodi, Marco; Strippoli, Raffaele - 01a Articolo in rivista
paper: CELL DEATH & DISEASE (Nature Group) pp. - - issn: 2041-4889 - wos: WOS:000885083500004 (1) - scopus: 2-s2.0-85142134241 (2)

11573/1467228 - 2021 - Novel Pyridine-Based Hydroxamates and 2'-Aminoanilides as Histone Deacetylase Inhibitors: Biochemical Profile and Anticancer Activity
Zwergel, Clemens; Di Bello, Elisabetta; Fioravanti, Rossella; Mazzone, Roberta; Valente, Sergio; Mai, Antonello - 01a Articolo in rivista
paper: CHEMMEDCHEM (Weinheim : Wiley-VCH-Verl..) pp. 989-999 - issn: 1860-7179 - wos: WOS:000599084500001 (4) - scopus: 2-s2.0-85097525146 (4)

11573/1550470 - 2021 - Structure-Guided Development of Small-Molecule PRC2 Inhibitors Targeting EZH2–EED Interaction
Zwergel, Clemens; Valente, Sergio - 01a Articolo in rivista
paper: JOURNAL OF MEDICINAL CHEMISTRY (Washington, DC: American Chemical Society) pp. 8194-8207 - issn: 0022-2623 - wos: WOS:000668340800017 (10) - scopus: 2-s2.0-85108541842 (12)

11573/1564224 - 2021 - Histone-deacetylase 8 drives the immune response and the growth of glioma
Mormino, Alessandro; Cocozza, Germana; Valente, Sergio; Esposito, Vincenzo; Santoro, Antonio; Bernardini, Giovanni; Santoni, Angela; Fazi, Francesco; Mai, Antonello; Limatola, Cristina; Garofalo, Stefano - 01a Articolo in rivista
paper: GLIA (John Wiley & Sons Incorporated:Customer Service, 111 River Street:Hoboken, NJ 07030:(800)225-5945, (201)748-6000, EMAIL: societyinfo@wiley.com, INTERNET: http://www.wiley.com, Fax: (212)748-6551) pp. 1-17 - issn: 0894-1491 - wos: WOS:000678875900001 (6) - scopus: 2-s2.0-85111697220 (6)

11573/1564901 - 2021 - Polycomb repressive complex 2 modulation through the development of EZH2–EED interaction inhibitors and EED binders
Romanelli, Annalisa; Zwergel, Clemens; Valente, Sergio; Mai, Antonello - 01g Articolo di rassegna (Review)
paper: JOURNAL OF MEDICINAL CHEMISTRY (Washington, DC: American Chemical Society) pp. 11774-11797 - issn: 0022-2623 - wos: WOS:000692012400002 (9) - scopus: 2-s2.0-85114048578 (11)

11573/1565876 - 2021 - Editorial: new approaches to tackle EMT and fibrosis: from epigenetics to nanotechnology
Battistelli, Cecilia; Valente, Sergio; Strippoli, Raffaele - 01m Editorial/Introduzione in rivista
paper: FRONTIERS IN PHARMACOLOGY (Lausanne: Frontiers Media S.A., 2010-) pp. - - issn: 1663-9812 - wos: WOS:000686867300001 (0) - scopus: 2-s2.0-85113221898 (0)

11573/1613681 - 2021 - Editorial: Natural Product Epigenetic Modulators and Inhibitors
Valente, Sergio; Battistelli, Cecilia - 01m Editorial/Introduzione in rivista
paper: FRONTIERS IN PHARMACOLOGY (Lausanne: Frontiers Media S.A., 2010-) pp. - - issn: 1663-9812 - wos: WOS:000629965700001 (1) - scopus: 2-s2.0-85102865581 (1)

11573/1361035 - 2020 - Molecular mechanisms and new therapeutic targets in epithelial to mesenchymal transition (EMT) and fibrosis
Strippoli, Raffaele; Battistelli, Cecilia; Valente, Sergio - 01m Editorial/Introduzione in rivista
paper: FRONTIERS IN PHARMACOLOGY (Lausanne: Frontiers Media S.A., 2010-) pp. - - issn: 1663-9812 - wos: WOS:000510209700001 (1) - scopus: 2-s2.0-85078745922 (1)

11573/1364390 - 2020 - Novel quinoline compounds active in cancer cells through coupled DNA methyltransferase inhibition and degradation
Zwergel, Clemens; Fioravanti, Rossella; Stazi, Giulia; Battistelli, Cecilia; Romanelli, Annalisa; Lopes Mendes, Ana Ludy Da Conceicao; Strippoli, Raffaele; Tripodi, Marco; Valente, Sergio; Mai, Antonello - 01a Articolo in rivista
paper: CANCERS (Basel : MDPI) pp. - - issn: 2072-6694 - wos: WOS:000522477300193 (6) - scopus: 2-s2.0-85079504263 (6)

11573/1382315 - 2020 - Tranylcypromine-based LSD1 inhibitors: structure-activity relationships, antiproliferative effects in leukemia, and gene target modulation
Fioravanti, Rossella; Romanelli, Annalisa; Mautone, Nicola; Di Bello, Elisabetta; Rovere, Annarita; Corinti, Davide; Zwergel, Clemens; Valente, Sergio; Rotili, Dante; Mai, Antonello - 01a Articolo in rivista
paper: CHEMMEDCHEM (Weinheim : Wiley-VCH-Verl..) pp. 643-658 - issn: 1860-7179 - wos: WOS:000513271600001 (13) - scopus: 2-s2.0-85079446800 (15)

11573/1390388 - 2020 - Targeting the scaffolding role of LSD1 (KDM1A) poises acute myeloid leukemia cells for retinoic acid-induced differentiation
Valente, Sergio; Fioravanti, Rossella; Mai, Antonello - 01a Articolo in rivista
paper: SCIENCE ADVANCES (Washington, DC : American Association for the Advancement of Science, 2015-) pp. - - issn: 2375-2548 - wos: WOS:000525751400003 (31) - scopus: 2-s2.0-85083269142 (30)

11573/1390390 - 2020 - A closer look into NADPH oxidase inhibitors: validation and insight into their mechanism of action
Valente, Sergio; Mai, Antonello - 01a Articolo in rivista
paper: REDOX BIOLOGY (Amsterdam : Elsevier) pp. - - issn: 2213-2317 - wos: WOS:000537459900002 (35) - scopus: 2-s2.0-85079650979 (37)

11573/1390392 - 2020 - Altered mitochondrial function in cells carrying a premutation or unmethylated full mutation of the FMR1 gene
Ragno, Rino; Stazi, Giulia; Valente, Sergio; Mai, Antonello - 01a Articolo in rivista
paper: HUMAN GENETICS (Germany: Springer Verlag Germany) pp. 227-245 - issn: 0340-6717 - wos: WOS:000515839900006 (13) - scopus: 2-s2.0-85077526115 (13)

11573/1394955 - 2020 - Design of first-in-class dual EZH2/HDAC inhibitor: biochemical activity and biological evaluation in cancer cells
Romanelli, Annalisa; Stazi, Giulia; Fioravanti, Rossella; Zwergel, Clemens; Di Bello, Elisabetta; Battistelli, Cecilia; Strippoli, Raffaele; Tripodi, Marco; Mai, Antonello; Valente, Sergio - 01a Articolo in rivista
paper: ACS MEDICINAL CHEMISTRY LETTERS (USA: ACS Publications) pp. 977-983 - issn: 1948-5875 - wos: WOS:000535281200056 (27) - scopus: 2-s2.0-85087681122 (29)

11573/1414757 - 2020 - Discovery of the first human arylsulfatase a reversible inhibitor impairing mouse oocyte fertilization
Zwergel, Clemens; Pirolli, Adele; Sabatino, Manuela; Mai, Antonello; Altieri, Fabio; Canipari, Rita; Valente, Sergio; Ragno, Rino - 01a Articolo in rivista
paper: ACS CHEMICAL BIOLOGY (AMERICAN CHEMICAL SOCiety, 1155 16TH ST, NW, WASHINGTON, USA, DC, 20036) pp. 1349-1357 - issn: 1554-8929 - wos: WOS:000543662300010 (3) - scopus: 2-s2.0-85086748074 (3)

11573/1418417 - 2020 - The innovative potential of statins in cancer: new targets for new therapies
Di Bello, Elisabetta; Zwergel, Clemens; Mai, Antonello; Valente, Sergio - 01g Articolo di rassegna (Review)
paper: FRONTIERS IN CHEMISTRY (Lausanne : Frontiers Media S.A., 2013-) pp. - - issn: 2296-2646 - wos: WOS:000546786300001 (46) - scopus: 2-s2.0-85087290374 (50)

11573/1429805 - 2020 - Properly substituted cyclic Bis-(2-bromobenzylidene) compounds behaved as dual p300/CARM1 Inhibitors and Induced apoptosis in cancer cells
Fioravanti, Rossella; Di Bello, Elisabetta; Romanelli, Annalisa; Plateroti, Andrea Maria; Valente, Sergio; Mai, Antonello - 01a Articolo in rivista
paper: MOLECULES (Basel: MDPI Berlin: Springer, 1996-) pp. - - issn: 1420-3049 - wos: WOS:000558002500001 (1) - scopus: 2-s2.0-85088202424 (1)

11573/1434640 - 2020 - CDK9 as a valuable target in cancer: from natural compounds inhibitors to current treatment in pediatric soft tissue sarcomas
Fioravanti, Rossella; Valente, Sergio; Rotili, Dante; Mai, Antonello - 01a Articolo in rivista
paper: FRONTIERS IN PHARMACOLOGY (Lausanne: Frontiers Media S.A., 2010-) pp. - - issn: 1663-9812 - wos: WOS:000565986100001 (14) - scopus: 2-s2.0-85089884656 (17)

11573/1193778 - 2019 - Identification of novel quinazoline derivatives as potent antiplasmodial agents
Rotili, Dante; Valente, Sergio; Mazzone, Roberta; Lucidi, Alessia; Fabrizi, Giancarlo; Mai, Antonello - 01a Articolo in rivista
paper: EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY (Editions Scientifique & Medical Elsevier:23 Rue Linois, F 75724 Paris Cedex 15 France:011 33 1 71724646, INTERNET: http://www.elsevier.fr, Fax: 011 33 1 71724664) pp. 277-291 - issn: 0223-5234 - wos: WOS:000451498200018 (32) - scopus: 2-s2.0-85055197167 (36)

11573/1208206 - 2019 - Development of alkyl glycerone phosphate synthase inhibitors: Structure-activity relationship and effects on ether lipids and epithelial-mesenchymal transition in cancer cells
Stazi, Giulia; Battistelli, Cecilia; Mazzone, Roberta; Marrocco, Biagina; Zwergel, Clemens; Antonini, Lorenzo; Patsilinakos, Alexandros; Ragno, Rino; Ciogli, Alessia; Fabrizi, Giancarlo; Strippoli, Raffaele; Marchetti, Alessandra; Tripodi, Marco; Mattevi, Andrea; Mai, Antonello; Valente, Sergio - 01a Articolo in rivista
paper: EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY (Editions Scientifique & Medical Elsevier:23 Rue Linois, F 75724 Paris Cedex 15 France:011 33 1 71724646, INTERNET: http://www.elsevier.fr, Fax: 011 33 1 71724664) pp. 722-735 - issn: 0223-5234 - wos: WOS:000458597300053 (12) - scopus: 2-s2.0-85058530369 (12)

11573/1265927 - 2019 - Identification of a novel quinoline-based DNA demethylating compound highly potent in cancer cells
Zwergel, Clemens; Battistelli, Cecilia; Stazi, Giulia; Mazzone, Roberta; Fioravanti, Rossella; Strippoli, Raffaele; Tripodi, Marco; Mai, Antonello; Valente, Sergio - 01a Articolo in rivista
paper: CLINICAL EPIGENETICS (Berlin : Springer) pp. - - issn: 1868-7083 - wos: WOS:000467227900001 (24) - scopus: 2-s2.0-85065468885 (23)

11573/1275422 - 2019 - Sirtuins as drug targets
Zwergel, Clemens; Rotili, Dante; Valente, Sergio; Mai, Antonello - 02a Capitolo o Articolo
book: Epigenetic Drug Discovery - (9783527343140; 9783527809257)

11573/1275490 - 2019 - Epigenetic Pharmacology in Regenerative Medicine (Epi-Drugs)
Stazi, Giulia; Zwergel, Clemens; Valente, Sergio; Mai, Antonello - 02a Capitolo o Articolo
book: Epigenetics and Regeneration - (9780128148792)

11573/1339079 - 2019 - Dissecting the role of novel EZH2 inhibitors in primary glioblastoma cell cultures: effects on proliferation, epithelial-mesenchymal transition, migration, and on the pro-inflammatory phenotype
Stazi, Giulia; Taglieri, Ludovica; Nicolai, Alice; Romanelli, Annalisa; Fioravanti, Rossella; Morrone, Stefania; Sabatino, Manuela; Ragno, Rino; Taurone, Samanta; Nebbioso, Marcella; Carletti, Raffaella; Artico, Marco; Valente, Sergio; Scarpa, Susanna; Mai, Antonello - 01a Articolo in rivista
paper: CLINICAL EPIGENETICS (Berlin : Springer) pp. 1-17 - issn: 1868-7083 - wos: WOS:000501362500004 (37) - scopus: 2-s2.0-85076062797 (37)

11573/1382317 - 2019 - Lysine methyltransferases and their inhibitors
Stazi, Giulia; Zwergel, Clemens; Valente, Sergio - 02a Capitolo o Articolo
book: Chemical Epigenetics - (978-3-030-42981-2; 978-3-030-42982-9)

11573/1390394 - 2019 - The Protein Arginine Methyltransferases 1 and 5 affect Myc properties in glioblastoma stem cells
Valente, Sergio; Mai, Antonello; Scagnoli, Fiorella - 01a Articolo in rivista
paper: SCIENTIFIC REPORTS (London : Nature Publishing Group) pp. 15925- - issn: 2045-2322 - wos: WOS:000493898100033 (21) - scopus: 2-s2.0-85074323285 (23)

11573/1390396 - 2019 - Histone deacetylases contribute to excitotoxicity-triggered degeneration of retinal ganglion cells in vivo
Fioravanti, Rossella; Valente, Sergio; Mai, Antonello - 01a Articolo in rivista
paper: MOLECULAR NEUROBIOLOGY (Humana Press Incorporated:999 Riverview Drive, Suite 208:Totowa, NJ 07512:(973)256-1699, EMAIL: lglasner@humanapr.com, INTERNET: http://www.humanapress.com, Fax: (973)256-8341) pp. 8018-8034 - issn: 0893-7648 - wos: WOS:000494860800008 (14) - scopus: 2-s2.0-85067067374 (14)

11573/1390399 - 2019 - Statins and histone deacetylase inhibitors affect lamin A/C - histone deacetylase 2 interaction in human cells
Mai, Antonello; Valente, Sergio - 01a Articolo in rivista
paper: FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY (Lausanne : Frontiers Media S.A., 2013-) pp. - - issn: 2296-634X - wos: WOS:000467197300001 (16) - scopus: 2-s2.0-85075855435 (13)

11573/1416968 - 2019 - Histone deacetylases as an epigenetic pillar for the development of hybrid inhibitors in cancer
Stazi, Giulia; Fioravanti, Rossella; Mai, Antonello; Valente, Sergio - 01g Articolo di rassegna (Review)
paper: CURRENT OPINION IN CHEMICAL BIOLOGY (Current Biology Limited:84 Theobalds Road, London WC1X 8RR United Kingdom:011 44 20 76114202, EMAIL: info@biomednet.com, INTERNET: http://www.biomednet.com, Fax: 011 44 20 76114479) pp. 89-100 - issn: 1367-5931 - wos: WOS:000473839100012 (20) - scopus: 2-s2.0-85064167463 (22)

11573/1074176 - 2018 - Targeting the CoREST complex with dual histone deacetylase and demethylase inhibitors
Valente, Sergio; Mai, Antonello; Mattevi, Andrea - 01a Articolo in rivista
paper: NATURE COMMUNICATIONS (London: Nature Publishing Group) pp. - - issn: 2041-1723 - wos: WOS:000419404200003 (139) - scopus: 2-s2.0-85040217796 (137)

11573/1120934 - 2018 - HDAC1 inhibition by MS-275 in mesothelial cells limits cellular invasion and promotes MMT reversal
Rossi, Lucia; Battistelli, Cecilia; De Turris, Valeria; Noce, Valeria; Zwergel, Clemens; Valente, Sergio; Moioli, Alessandra; Manzione, Andrea; Palladino, Marco; Domenici, Alessandro; Mene', Paolo; Mai, Antonello; Tripodi, Marco; Strippoli, Raffaele - 01a Articolo in rivista
paper: OPEN ACCESS SCIENTIFIC REPORTS (Los Angeles, CA : OMICS Publishing Group, [2012]-) pp. - - issn: 2332-2675 - wos: WOS:000433547600053 (16) - scopus: 2-s2.0-85048002226 (17)

11573/1147229 - 2018 - Effects of class II-selective histone deacetylase inhibitor on neuromuscular function and disease progression in SOD1-ALS mice
Ranieri, Giuseppe Antonio; Zwergel, Clemens; Valente, Sergio; Mai, Antonello - 01a Articolo in rivista
paper: NEUROSCIENCE (Oxford: Elsevier Ltd. Oxford; New York: Pergamon Press) pp. 228-238 - issn: 0306-4522 - wos: WOS:000430884100020 (15) - scopus: 2-s2.0-85044974964 (15)

11573/1147233 - 2018 - Pyrazole-based inhibitors of enhancer of zeste homologue 2 induce apoptosis and autophagy in cancer cells
Mellini, Paolo; Marrocco, Biagina; Polletta, Lucia; Carnevale, Ilaria; Saladini, Serena; Stazi, Giulia; Zwergel, Clemens; Ferretti, Elisabetta; Tafani, Marco; Valente, Sergio; Mai, Antonello - 01a Articolo in rivista
paper: PHILOSOPHICAL TRANSACTIONS - ROYAL SOCIETY. BIOLOGICAL SCIENCES (Royal Society of London) pp. 20170150- - issn: 0962-8436 - wos: WOS:000430738400014 (16) - scopus: 2-s2.0-85045959069 (17)

11573/1147235 - 2018 - Trends of LSD1 inhibitors in viral infections
Zwergel, Clemens; Stazi, Giulia; Mai, Antonello; Valente, Sergio - 01a Articolo in rivista
paper: FUTURE MEDICINAL CHEMISTRY (London : Future Science, 2009-.) pp. 1133-1135 - issn: 1756-8919 - wos: WOS:000433568500001 (10) - scopus: 2-s2.0-85048066484 (10)

11573/1147237 - 2018 - Combined HAT/EZH2 modulation leads to cancer-selective cell death
Valente, Sergio; Tomassi, Stefano; Sbardella, Gianluca; Mai, Antonello - 01a Articolo in rivista
paper: ONCOTARGET (Albany, N.Y. : Impact Journals) pp. 25630-25646 - issn: 1949-2553 - wos: (0) - scopus: 2-s2.0-85047400725 (6)

11573/1147239 - 2018 - Multi-omics profiling reveals a distinctive epigenome signature for high-risk acute promyelocytic leukemia
Valente, Sergio; Mai, Antonello - 01a Articolo in rivista
paper: ONCOTARGET (Albany, N.Y. : Impact Journals) pp. 25647-25660 - issn: 1949-2553 - wos: (0) - scopus: 2-s2.0-85047385574 (12)

11573/1147243 - 2018 - Altered modulation of lamin A/C-HDAC2 interaction and p21 expression during oxidative stress response in HGPS
Valente, Sergio; Mai, Antonello - 01a Articolo in rivista
paper: AGING CELL ([Oxford] : Blackwell Science Ltd, 2002-) pp. - - issn: 1474-9726 - wos: WOS:000445599100019 (28) - scopus: 2-s2.0-85052612287 (24)

11573/1147245 - 2018 - Nucleocytoplasmic export of HDAC5 and SIRT2 downregulation: two epigenetic mechanisms by which antidepressants enhance synaptic plasticity markers
Zwergel, Clemens; Cirilli, Raffaela; Mai, Antonello; Valente, Sergio - 01a Articolo in rivista
paper: PSYCHOPHARMACOLOGY (Heidelberg; Berlin: Springer) pp. 2831-2846 - issn: 0033-3158 - wos: WOS:000446140500005 (8) - scopus: 2-s2.0-85051492076 (7)

11573/1147949 - 2018 - A quinoline-based DNA methyltransferase inhibitor as a possible adjuvant in osteosarcoma therapy
Valente, Sergio; Zwergel, Clemens; Mazzone, Roberta; Stazi, Giulia; Mai, Antonello - 01a Articolo in rivista
paper: MOLECULAR CANCER THERAPEUTICS (Philadelphia, PA : American Association for Cancer Research, c2001-) pp. 1881-1892 - issn: 1535-7163 - wos: WOS:000444041300008 (23) - scopus: 2-s2.0-85053014459 (22)

11573/1174048 - 2018 - Six years (2012-2018) of researches on catalytic EZH2 inhibitors: the boom of the 2-pyridone compounds
Fioravanti, Rossella; Stazi, Giulia; Zwergel, Clemens; Valente, Sergio; Mai, Antonello - 01a Articolo in rivista
paper: THE CHEMICAL RECORD (New York N.Y.: Wiley, c2000-) pp. 1818-1832 - issn: 1527-8999 - wos: WOS:000453386600014 (59) - scopus: 2-s2.0-85055289007 (61)

11573/1202973 - 2018 - Application of small epigenetic modulators in pediatric medulloblastoma
Zwergel, Clemens; Romanelli, Annalisa; Stazi, Giulia; Besharat, Zein Mersini; Catanzaro, Giuseppina; Tafani, Marco; Valente, Sergio; Mai, Antonello - 01a Articolo in rivista
paper: FRONTIERS IN PEDIATRICS (Lausanne : Frontiers Media S.A., 2013-) pp. - - issn: 2296-2360 - wos: WOS:000452081000001 (10) - scopus: 2-s2.0-85058706178 (10)

11573/1017602 - 2017 - EZH2 inhibitors: a patent review (2014-2016)
Stazi, Giulia; Zwergel, Clemens; Mai, Antonello; Valente, Sergio - 01a Articolo in rivista
paper: EXPERT OPINION ON THERAPEUTIC PATENTS (--London United Kingdom:Informa Healthcare -London, United Kingdom: Ashley Publications Limited) pp. 797-813 - issn: 1354-3776 - wos: WOS:000405302700004 (33) - scopus: 2-s2.0-85020639378 (33)

11573/1017610 - 2017 - The histone methyltransferase EZH2 as a druggable target in SHH medulloblastoma cancer stem cells
Miele, Evelina; Valente, Sergio; Alfano, Vincenzo; Silvano, Marianna; Mellini, Paolo; Marrocco, Biagina; Po, Agnese; Besharat, Zein Mersini; Catanzaro, Giuseppina; Battaglia, Giuseppe; Abballe, Luana; Zwergel, Clemens; Stazi, Giulia; Tafani, Marco; Mai, Antonello; Ferretti, Elisabetta - 01a Articolo in rivista
paper: ONCOTARGET (Albany, N.Y. : Impact Journals) pp. 68557-68570- - issn: 1949-2553 - wos: WOS:000410790500145 (32) - scopus: 2-s2.0-85040235337 (33)

11573/1092479 - 2017 - Effect of Class II HDAC inhibition on glutamate transporter expression and survival in SOD1-ALS mice
Zwergel, Clemens; Valente, Sergio; Mai, Antonello - 01a Articolo in rivista
paper: NEUROSCIENCE LETTERS (Elsevier Science Ireland Limited:PO Box 85, Limerick Ireland:011 353 61 709600, 011 353 61 61944, EMAIL: usinfo-f@elsevier.com, INTERNET: http://www.elsevier.com, Fax: 011 353 61 709114) pp. 120-125 - issn: 0304-3940 - wos: WOS:000409288600019 (16) - scopus: 2-s2.0-85026360880 (18)

11573/1192249 - 2017 - Structure-activity relationships on cynnamoyl derivatives as inhibitors of p300 Histone acetyltransferase
Madia, Valentina Noemi; Pescatori, Luca; Messore, Antonella; Pupo, Giovanni; Saccoliti, Francesco; Valente, Sergio; Mai, Antonello; Scipione, Luigi; Di Santo, Roberto; Costi, Roberta - 01a Articolo in rivista
paper: CHEMMEDCHEM (Weinheim : Wiley-VCH-Verl..) pp. 1359-1368 - issn: 1860-7187 - wos: WOS:000429592300014 (9) - scopus: 2-s2.0-85017448829 (8)

11573/955887 - 2017 - Novel coumarin- and quinolinone-based polycycles as cell division cycle 25-A and -C phosphatases inhibitors induce proliferation arrest and apoptosis in cancer cells
Zwergel, Clemens; Stazi, Giulia; Mori, Mattia; Patsilinakos, Alexandros; Mai, Antonello; Botta, Bruno; Ragno, Rino; Kirsch, Gilbert; Valente, Sergio - 01a Articolo in rivista
paper: EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY (Editions Scientifique & Medical Elsevier:23 Rue Linois, F 75724 Paris Cedex 15 France:011 33 1 71724646, INTERNET: http://www.elsevier.fr, Fax: 011 33 1 71724664) pp. 316-333 - issn: 0223-5234 - wos: WOS:000401677500027 (18) - scopus: 2-s2.0-85017548581 (19)

11573/972511 - 2017 - Epi-drugs in combination with immunotherapy: a new avenue to improve anticancer efficacy
Mazzone, Roberta; Zwergel, Clemens; Mai, Antonello; Valente, Sergio - 01a Articolo in rivista
paper: CLINICAL EPIGENETICS (Berlin : Springer) pp. 1-15 - issn: 1868-7083 - wos: WOS:000403112500004 (101) - scopus: 2-s2.0-85020006586 (102)

11573/851423 - 2016 - Histone deacetylase inhibitors restore IL-10 expression in lipopolysaccharide-induced cell inflammation and reduce IL-1β and IL-6 production in breast silicone implant in C57BL/6J wild-type murine model
Valente, Sergio; Taurone, Samanta; Zwergel, Clemens; Marrocco, Biagina; Turchetta, Rosaria; Mai, Antonello; Artico, Marco - 01a Articolo in rivista
paper: AUTOIMMUNITY (Amsterdam; New York: Harwood Academic Publishers.) pp. 1-11 - issn: 0891-6934 - wos: (0) - scopus: 2-s2.0-84955134169 (18)

11573/856751 - 2016 - Discovery of a novel inhibitor of histone lysine-specific demethylase 1A (KDM1A/LSD1) as orally active antitumor agent
Mai, Antonello; Marrocco, Biagina; Stazi, Giulia; Valente, Sergio - 01a Articolo in rivista
paper: JOURNAL OF MEDICINAL CHEMISTRY (Washington, DC: American Chemical Society) pp. 1501-1517 - issn: 0022-2623 - wos: WOS:000371103600018 (56) - scopus: 2-s2.0-84959421233 (58)

11573/870518 - 2016 - LSD1 inhibitors: a patent review (2010-2015)
Stazi, Giulia; Zwergel, Clemens; Valente, Sergio; Mai, Antonello - 01a Articolo in rivista
paper: EXPERT OPINION ON THERAPEUTIC PATENTS (--London United Kingdom:Informa Healthcare -London, United Kingdom: Ashley Publications Limited) pp. 565-580 - issn: 1354-3776 - wos: WOS:000374900000003 (42) - scopus: 2-s2.0-84961644830 (43)

11573/870523 - 2016 - 1,4-Dihydropyridines Active on the SIRT1/AMPK Pathway Ameliorate Skin Repair and Mitochondrial Function and Exhibit Inhibition of Proliferation in Cancer Cells
Valente, Sergio; Mellini, Paolo; Spallotta, Francesco; Polletta, Lucia; Carnevale, Ilaria; Saladini, Serena; Gabellini, Chiara; Tardugno, Maria; Zwergel, Clemens; Cencioni, Chiara; Tafani, Marco; Mai, Antonello - 01a Articolo in rivista
paper: JOURNAL OF MEDICINAL CHEMISTRY (Washington, DC: American Chemical Society) pp. 1471-1491 - issn: 0022-2623 - wos: WOS:000371103600016 (46) - scopus: 2-s2.0-84959335947 (50)

11573/870553 - 2016 - DNA methyltransferases Inhibitors from natural sources
Zwergel, Clemens; Valente, Sergio; Mai, Antonello - 01a Articolo in rivista
paper: CURRENT TOPICS IN MEDICINAL CHEMISTRY (Hilversum : Bentham Science Publishers) pp. 680-696 - issn: 1568-0266 - wos: WOS:000364586000004 (40) - scopus: 2-s2.0-84983215072 (45)

11573/931824 - 2016 - MC1568 inhibits HDAC6/8 activity and influenza A virus replication in lung epithelial cells: Role of Hsp90 acetylation
Panella, Simona; Marcocci, Maria Elena; Celestino, Ignacio; Valente, Sergio; Zwergel, Clemens; Nencioni, Lucia; Mai, Antonello; Palamara, Anna Teresa; Simonetti, Giovanna - 01a Articolo in rivista
paper: FUTURE MEDICINAL CHEMISTRY (London : Future Science, 2009-.) pp. 2017-2031 - issn: 1756-8919 - wos: WOS:000386339500004 (23) - scopus: 2-s2.0-84994010342 (25)

11573/1667577 - 2015 - PTPS-03EPIGENETIC SILENCING OF β-ARRESTIN1 AND ITS INTRAGENIC miR-326 CONTROLS MEDULLOBLASTOMA GROWTH
Miele, Evelina; Po, Agnese; Valente, Sergio; Screpanti, Isabella; Giangaspero, Felice; Levrero, Massimo; Ferretti, Elisabetta - 01h Abstract in rivista
paper: NEURO-ONCOLOGY (First or current publisher Charlottesville, VA : Carden Jennings Pub., [1999- Intervening publisher Durham, NC : Duke University Press Current or last publisher Oxford, UK : Oxford University Press) pp. - - issn: 1523-5866 - wos: (0) - scopus: (0)

11573/779609 - 2015 - Pyrrole- and indole-containing tranylcypromine derivatives as novel lysine-specific demethylase 1 inhibitors active on cancer cells.
Valente, Sergio; Rotili, Dante; Stazi, Giulia; Lucidi, Alessia; Mai, Antonello - 01a Articolo in rivista
paper: MEDCHEMCOMM (Cambridge : Royal Society of Chemistry, 2010-) pp. 665-670 - issn: 2040-2503 - wos: WOS:000352903400023 (22) - scopus: 2-s2.0-84928004801 (22)

11573/781693 - 2015 - Pure enantiomers of benzoylamino-tranylcypromine: LSD1 inhibition, gene modulation in human leukemia cells and effects on clonogenic potential of murine promyelocytic blasts
Valente, Sergio; Rodriguez Aedo, Verónica Alejandra; Labella, Donatella; Marrocco, Biagina; Ruoppolo, Giovanni; Mattevi, Andrea; Mai, Antonello - 01a Articolo in rivista
paper: EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY (Editions Scientifique & Medical Elsevier:23 Rue Linois, F 75724 Paris Cedex 15 France:011 33 1 71724646, INTERNET: http://www.elsevier.fr, Fax: 011 33 1 71724664) pp. 163-174 - issn: 0223-5234 - wos: WOS:000353730900016 (27) - scopus: 2-s2.0-84924406877 (28)

11573/781696 - 2015 - Pure diastereomers of a tranylcypromine-based LSD1 inhibitor: enzyme selectivity and in-cell studies
Valente, Sergio; Labella, Donatella; Marrocco, Biagina; Ruoppolo, Giovanni; Mai, Antonello - 01a Articolo in rivista
paper: ACS MEDICINAL CHEMISTRY LETTERS (USA: ACS Publications) pp. 173-177 - issn: 1948-5875 - wos: WOS:000349652000012 (20) - scopus: 2-s2.0-84922867052 (17)

11573/784164 - 2015 - Interplay among nucleosomal DNA, histone tails, and corepressor CoREST underlies LSD1-mediated H3 demethylation
Valente, Sergio; Mai, Antonello - 01a Articolo in rivista
paper: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (National Academy of Sciences:2101 Constitution Avenue Northwest:Washington, DC 20418:(877)314-2253, (615)377-3322, EMAIL: subspnas@nas.edu, INTERNET: http://www.pnas.org, Fax: (615)377-0525) pp. 2752-2757 - issn: 0027-8424 - wos: WOS:000350224900048 (58) - scopus: 2-s2.0-84924368105 (62)

11573/784167 - 2015 - Novel histone deacetylase inhibitors induce growth arrest, apoptosis, and differentiation in sarcoma cancer stem cells
Rotili, Dante; Valente, Sergio; Zwergel, Clemens; Mai, Antonello - 01a Articolo in rivista
paper: JOURNAL OF MEDICINAL CHEMISTRY (Washington, DC: American Chemical Society) pp. 4073-4079 - issn: 0022-2623 - wos: WOS:000354911200031 (50) - scopus: 2-s2.0-84929378676 (47)

11573/856754 - 2015 - Discovery of inhibitors for the ether lipid-generating enzyme AGPS as anti-cancer agents
Valente, Sergio; Marrocco, Biagina; Mai, Antonello - 01a Articolo in rivista
paper: ACS CHEMICAL BIOLOGY (AMERICAN CHEMICAL SOCiety, 1155 16TH ST, NW, WASHINGTON, USA, DC, 20036) pp. 2589-2597 - issn: 1554-8929 - wos: WOS:000365462700020 (46) - scopus: 2-s2.0-84947909618 (45)

11573/870535 - 2015 - Emerging approaches for histone deacetylase inhibitor drug discovery
Zwergel, Clemens; Valente, Sergio; Mai, Antonello - 01a Articolo in rivista
paper: EXPERT OPINION ON DRUG DISCOVERY (--London United Kingdom:Informa Healthcare -London : Informa Healthcare, 2006-.) pp. 599-613 - issn: 1746-0441 - wos: WOS:000355006600004 (54) - scopus: 2-s2.0-84929928202 (55)

11573/870559 - 2015 - Abstract 2946: Effects of two novel quinoline-based non-nucleoside DNA methyltransferase inhibitors against bone sarcomas
Valente, Sergio; Zwergel, Clemens; Mai, Antonello - 04d Abstract in atti di convegno
paper: CANCER RESEARCH (American Association of Cancer Research:150 South Independence Mall West, #826:Philadelphia, PA 19106:(215)440-9300, EMAIL: pubs@aacr.org, INTERNET: http://www.aacr.org, Fax: (215)440-7228) pp. 2946-2946 - issn: 0008-5472 - wos: WOS:000371578506091 (0) - scopus: (0)

11573/884185 - 2015 - Chronic stress and antidepressant induced changes in Hdac5 and Sirt2 affect synaptic plasticity
Mai, Antonello; Valente, Sergio - 01a Articolo in rivista
paper: EUROPEAN NEUROPSYCHOPHARMACOLOGY (Elsevier BV:PO Box 211, 1000 AE Amsterdam Netherlands:011 31 20 4853757, 011 31 20 4853642, 011 31 20 4853641, EMAIL: nlinfo-f@elsevier.nl, INTERNET: http://www.elsevier.nl, Fax: 011 31 20 4853598) pp. 2036-2048 - issn: 0924-977X - wos: WOS:000369152500020 (41) - scopus: 2-s2.0-84947494371 (43)

11573/884188 - 2015 - Targeting lysine deacetylases (KDACs) in parasites
Valente, Sergio; Rotili, Dante; Mai, Antonello - 01a Articolo in rivista
paper: PLOS NEGLECTED TROPICAL DISEASES (San Francisco, CA : Public Library of Science) pp. e000426- - issn: 1935-2727 - wos: WOS:000363031200020 (34) - scopus: 2-s2.0-84943193825 (37)

11573/884225 - 2015 - New insights on the mechanism of quinoline-based DNA methyltransferase inhibitors
Valente, Sergio; Mai, Antonello - 01a Articolo in rivista
paper: THE JOURNAL OF BIOLOGICAL CHEMISTRY (American Society for Biochemistry and Molecular Biology:9650 Rockville Pike:Bethesda, MD 20814:(301)530-7145, EMAIL: asbmb@asbmb.faseb.org, INTERNET: http://www.faseb.org/asbmb, Fax: (301)571-1824) pp. 6293-6302 - issn: 0021-9258 - wos: WOS:000350732500035 (41) - scopus: 2-s2.0-84924897991 (46)

11573/1155213 - 2014 - Sirtuins blunt reactive gliosis in an in vitro model of Alzheimer’s disease.
Bronzuoli, Maria Rosanna; Scuderi, Caterina; Stecca, Claudia; Rotili, Dante; Valente, Sergio; Mai, Antonello; Steardo, Luca - 04d Abstract in atti di convegno
conference: 17° Simposio SIF Dottorandi, Assegnisti di Ricerca Postdottorandi e Specializzandi in Farmacologia e Scienze Affini (Rimini)
book: 17° Simposio SIF Dottorandi, Assegnisti di Ricerca Postdottorandi e Specializzandi in Farmacologia e Scienze Affini. - ()

11573/542432 - 2014 - Pan-histone demethylase inhibitors simultaneously targeting Jumonji C and lysine-specific demethylases display high anticancer activities
Rotili, Dante; Valente, Sergio; Marrocco, Biagina; Labella, Donatella; Mai, Antonello - 01a Articolo in rivista
paper: JOURNAL OF MEDICINAL CHEMISTRY (Washington, DC: American Chemical Society) pp. 42-55 - issn: 0022-2623 - wos: WOS:000329677800004 (88) - scopus: 2-s2.0-84892565144 (96)

11573/547528 - 2014 - Selective Non-nucleoside Inhibitors of Human DNA Methyltransferases Active in Cancer Including in Cancer Stem Cells
Valente, Sergio; Zwergel, Clemens; Miele, Evelina; Ferretti, Elisabetta; Gulino, Alberto; Mai, Antonello - 01a Articolo in rivista
paper: JOURNAL OF MEDICINAL CHEMISTRY (Washington, DC: American Chemical Society) pp. 701-713 - issn: 0022-2623 - wos: WOS:000331493000013 (84) - scopus: 2-s2.0-84894065301 (90)

11573/556419 - 2014 - Context-Selective Death of Acute Myeloid Leukemia Cells Triggered by the Novel Hybrid Retinoid-HDAC Inhibitor MC2392.
Rotili, Dante; Valente, Sergio; Mai, Antonello - 01a Articolo in rivista
paper: CANCER RESEARCH (American Association of Cancer Research:150 South Independence Mall West, #826:Philadelphia, PA 19106:(215)440-9300, EMAIL: pubs@aacr.org, INTERNET: http://www.aacr.org, Fax: (215)440-7228) pp. 2328-2339 - issn: 0008-5472 - wos: WOS:000334584200020 (29) - scopus: 2-s2.0-84899541163 (33)

11573/557642 - 2014 - Reversible acetylation regulates vascular endothelial growth factor receptor-2 activity
Mai, Antonello; Valente, Sergio - 01a Articolo in rivista
paper: JOURNAL OF MOLECULAR CELL BIOLOGY (Shanghai : Journal of Molecular Cell Biology Editorial Office Oxford University Press) pp. 116-127 - issn: 1674-2788 - wos: WOS:000336081100003 (24) - scopus: 2-s2.0-84899675551 (27)

11573/557645 - 2014 - Pharmacological inhibition of EZH2 as a promising differentiation therapy in embryonal RMS
De Salvo, Maria; Screpanti, Isabella; Valente, Sergio; Mai, Antonello; Locatelli, Franco - 01a Articolo in rivista
paper: BMC CANCER (BIOMED CENTRAL LTD, MIDDLESEX HOUSE, 34-42 CLEVELAND ST, LONDON, ENGLAND, W1T 4LB) pp. 139- - issn: 1471-2407 - wos: WOS:000332528100001 (44) - scopus: 2-s2.0-84898597003 (50)

11573/643824 - 2014 - Sirtuin modulators control reactive gliosis in an in vitro model of alzheimer's disease
Scuderi, Caterina; Stecca, Claudia; Bronzuoli, Maria Rosanna; Rotili, Dante; Valente, Sergio; Mai, Antonello; Steardo, Luca - 01a Articolo in rivista
paper: FRONTIERS IN PHARMACOLOGY (Lausanne: Frontiers Media S.A., 2010-) pp. - - issn: 1663-9812 - wos: WOS:000347086800001 (47) - scopus: 2-s2.0-84904631078 (51)

11573/664039 - 2014 - Evaluation of ∆2-pioglitazone, an analogue of pioglitazone, on colon cancer cell survival: Evidence of drug treatment association with autophagy and activation of the Nrf2/Keap1 pathway
Valente, Sergio - 01a Articolo in rivista
paper: INTERNATIONAL JOURNAL OF ONCOLOGY (National Hellenic Research Foundation:48 Vas Constatinou Avenue, Athens 11635 Greece:011 30 1 7241505, Fax: 011 30 1 7241505Editore attuale:PROFESSOR D A SPANDIDOS, 1, S MERKOURI ST, EDITORIAL OFFICE,, ATHENS, GREECE, 116 35. Editore precedente:Editorial Academy of the International Journal of Oncology.) pp. 426-438 - issn: 1019-6439 - wos: WOS:000336881600046 (11) - scopus: 2-s2.0-84902598036 (11)

11573/664047 - 2014 - Small-molecule inhibitors of histone deacetylase for the treatment of cancer and non-cancer diseases: a patent review (2011 - 2013).
Valente, Sergio; Mai, Antonello - 01a Articolo in rivista
paper: EXPERT OPINION ON THERAPEUTIC PATENTS (--London United Kingdom:Informa Healthcare -London, United Kingdom: Ashley Publications Limited) pp. 401-415 - issn: 1354-3776 - wos: WOS:000333098200003 (38) - scopus: 2-s2.0-84896470334 (39)

11573/664054 - 2014 - PRMT1 arginine methyltransferase accumulates in cytoplasmic bodies that respond to selective inhibition and DNA damage
Valente, Sergio; Labella, Donatella; Mai, Antonello - 01a Articolo in rivista
paper: EUROPEAN JOURNAL OF HISTOCHEMISTRY (Pavia : PagePress Publications, 2010) pp. 139-151 - issn: 2038-8306 - wos: WOS:000338624700013 (10) - scopus: 2-s2.0-84899705373 (9)

11573/664060 - 2014 - 1,3,4-Oxadiazole-Containing Histone Deacetylase Inhibitors: Anticancer Activities in Cancer Cells
Valente, Sergio; Labella, Donatella; Lenoci, Alessia ; Mai, Antonello - 01a Articolo in rivista
paper: JOURNAL OF MEDICINAL CHEMISTRY (Washington, DC: American Chemical Society) pp. 6259-6265 - issn: 0022-2623 - wos: WOS:000339540800033 (90) - scopus: 2-s2.0-84904962606 (95)

11573/665415 - 2014 - Novel inhibitors of human histone deacetylases: Design, synthesis and bioactivity of 3-alkenoylcoumarines
Zwergel, Clemens; Mai, Antonello; Valente, Sergio - 01a Articolo in rivista
paper: BIOORGANIC & MEDICINAL CHEMISTRY LETTERS (Elsevier Science Limited:Oxford Fulfillment Center, PO Box 800, Kidlington Oxford OX5 1DX United Kingdom:011 44 1865 843000, 011 44 1865 843699, EMAIL: asianfo@elsevier.com, tcb@elsevier.co.UK, INTERNET: http://www.elsevier.com, http://www.elsevier.com/locate/shpsa/, Fax: 011 44 1865 843010) pp. 3797-3801 - issn: 0960-894X - wos: WOS:000340565900024 (39) - scopus: 2-s2.0-84905916821 (43)

11573/665612 - 2014 - Synthesis, biological activity and mechanistic insights of 1-substituted cyclopropylamine derivatives: A novel class of irreversible inhibitors of histone demethylase KDM1A
Mai, Antonello; Valente, Sergio - 01a Articolo in rivista
paper: EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY (Editions Scientifique & Medical Elsevier:23 Rue Linois, F 75724 Paris Cedex 15 France:011 33 1 71724646, INTERNET: http://www.elsevier.fr, Fax: 011 33 1 71724664) pp. 352-363 - issn: 0223-5234 - wos: WOS:000343781800032 (45) - scopus: 2-s2.0-84906839626 (44)

11573/665613 - 2014 - Sirtuin modulators: an updated patent review (2012 - 2014)
Valente, Sergio; Mai, Antonello - 01a Articolo in rivista
paper: EXPERT OPINION ON THERAPEUTIC PATENTS (--London United Kingdom:Informa Healthcare -London, United Kingdom: Ashley Publications Limited) pp. 5-15 - issn: 1354-3776 - wos: WOS:000346742700002 (43) - scopus: 2-s2.0-84919458504 (44)

11573/670458 - 2014 - The Polycomb group (PcG) protein EZH2 supports the survival of PAX3-FOXO1 alveolar rhabdomyosarcoma by repressing FBXO32 (Atrogin1/MAFbx)
De Salvo, Maria; Adesso, Laura; Alaggio, Rita; Screpanti, Isabella; Valente, Sergio; Mai, Antonello; Locatelli, Franco - 01a Articolo in rivista
paper: ONCOGENE (Macmillan Magazines Limited:Porters South Crinian Street, London N1 9XW United Kingdom:011 44 207 8334000, 011 44 171 8434982, Fax: 011 44 207 812358) pp. 4173-4184 - issn: 0950-9232 - wos: WOS:000340595700008 (52) - scopus: 2-s2.0-84905868284 (57)

11573/799567 - 2014 - Chalcone-Coumarin derivatives as potential anti-cancer drugs: an in vitro and in vivo investigation
Valente, Sergio - 01a Articolo in rivista
paper: ANTI-CANCER AGENTS IN MEDICINAL CHEMISTRY (Bussum : Bentham Science Publishers) pp. 963-974 - issn: 1875-5992 - wos: WOS:000341884600006 (26) - scopus: 2-s2.0-84905639421 (29)

11573/513467 - 2013 - Inhibition of Class I Histone Deacetylases Unveils a Mitochondrial Signature and Enhances Oxidative Metabolism in Skeletal Muscle and Adipose Tissue.
Rotili, Dante; Valente, Sergio; Mai, Antonello - 01a Articolo in rivista
paper: DIABETES (American Diabetes Association:National Service Center, 1701 North Beaureguard Street:Alexandria, VA 22311:(800)232-3472, (703)549-1500, INTERNET: http://www.diabetes.org/diabetscare, Fax: (703)549-6995) pp. 732-742 - issn: 0012-1797 - wos: WOS:000315556400017 (168) - scopus: 2-s2.0-84869106554 (176)

11573/513468 - 2013 - Class II HDAC Inhibition Hampers Hepatic Stellate Cell Activation by Induction of MicroRNA-29
Valente, Sergio; Mai, Antonello - 01a Articolo in rivista
paper: PLOS ONE (San Francisco, CA : Public Library of Science) pp. e55786- - issn: 1932-6203 - wos: WOS:000314610600159 (52) - scopus: 2-s2.0-84873122711 (57)

11573/513469 - 2013 - A Nitric Oxide-dependent Crosstalk Between Class I and III Histone Deacetylases Accelerates Skin Repair.
Spallotta, Francesco; Valente, Sergio; Mai, Antonello - 01a Articolo in rivista
paper: THE JOURNAL OF BIOLOGICAL CHEMISTRY (American Society for Biochemistry and Molecular Biology:9650 Rockville Pike:Bethesda, MD 20814:(301)530-7145, EMAIL: asbmb@asbmb.faseb.org, INTERNET: http://www.faseb.org/asbmb, Fax: (301)571-1824) pp. - - issn: 0021-9258 - wos: WOS:000317915500007 (59) - scopus: 2-s2.0-84876580701 (62)

11573/514588 - 2013 - tert-Butylcarbamate-Containing Histone Deacetylase Inhibitors: Apoptosis Induction, Cytodifferentiation, and Antiproliferative Activities in Cancer Cells.
Valente, Sergio; Labella, Donatella; Secci, Daniela; Mai, Antonello - 01a Articolo in rivista
paper: CHEMMEDCHEM (Weinheim : Wiley-VCH-Verl..) pp. - - issn: 1860-7179 - wos: WOS:000318245300013 (15) - scopus: 2-s2.0-84877064105 (16)

11573/525042 - 2013 - Detrimental effect of class-selective histone deacetylase inhibitors during tissue regeneration following hindlimb ischemia
Spallotta, Francesco; Mai, Antonello; Valente, Sergio; Martone, Julie; Bozzoni, Irene - 01a Articolo in rivista
paper: THE JOURNAL OF BIOLOGICAL CHEMISTRY (American Society for Biochemistry and Molecular Biology:9650 Rockville Pike:Bethesda, MD 20814:(301)530-7145, EMAIL: asbmb@asbmb.faseb.org, INTERNET: http://www.faseb.org/asbmb, Fax: (301)571-1824) pp. 22915-22929 - issn: 0021-9258 - wos: WOS:000330598200004 (27) - scopus: 2-s2.0-84881396773 (25)

11573/525043 - 2013 - Reactivity of 4-vinyl-2H-1-benzopyran-2-ones in diels-alder cycloaddition reactions: Access to coumarin-based polycycles with Cdc25 phosphatase-inhibiting activity
Valente, Sergio; Zwergel, Clemens; Mai, Antonello - 01a Articolo in rivista
paper: EUROPEAN JOURNAL OF ORGANIC CHEMISTRY (Wiley-VCH Verlag GmBH:PO Box 101161, D 69451 Weinheim Germany:011 49 6201 606147, EMAIL: service@wiley-vch.de, INTERNET: http://www.wiley-vch.de, Fax: 011 49 6201 606328) pp. 2869-2877 - issn: 1434-193X - wos: WOS:000318803200018 (10) - scopus: 2-s2.0-84877688906 (11)

11573/525990 - 2013 - Oxidative stress and epigenetic regulation in ageing and age-related diseases
Spallotta, Francesco; Valente, Sergio; Mai, Antonello - 01a Articolo in rivista
paper: INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (Basel (Matthaeustrasse 11) : Molecular Diversity Preservation International MDPI) pp. 17643-17663 - issn: 1661-6596 - wos: WOS:000328623900021 (140) - scopus: 2-s2.0-84883479431 (156)

11573/529785 - 2013 - A novel coumarin-quinone derivative SV37 inhibits CDC25 phosphatases, impairs proliferation, and induces cell death.
Valente, Sergio - 01a Articolo in rivista
paper: MOLECULAR CARCINOGENESIS (editore attuale: WILEY-LISS, DIV JOHN WILEY & SONS INC, 111 RIVER ST, HOBOKEN, USA, NJ, 07030. editore precedente: New York, NY : Wiley-Liss.) pp. n/a-n/a - issn: 0899-1987 - wos: WOS:000347828600006 (24) - scopus: 2-s2.0-84926088320 (29)

11573/870542 - 2013 - Novel benzofuran-chromone and -coumarin derivatives: Synthesis and biological activity in K562 human leukemia cells
Zwergel, Clemens; Valente, Sergio; Mai, Antonello - 01a Articolo in rivista
paper: MEDCHEMCOMM (Cambridge : Royal Society of Chemistry, 2010-) pp. 1571-1579 - issn: 2040-2503 - wos: WOS:000327461300005 (43) - scopus: 2-s2.0-84888154287 (46)

11573/443820 - 2012 - Coumarin polysulfides inhibit cell growth and induce apoptosis in HCT116 colon cancer cells
Valente, Sergio - 01a Articolo in rivista
paper: BIOORGANIC & MEDICINAL CHEMISTRY (Oxford: Pergamon, 1993-) pp. 1584-1593 - issn: 0968-0896 - wos: WOS:000300391200024 (53) - scopus: 2-s2.0-84857033328 (55)

11573/455694 - 2012 - Identification of PR-SET7 and EZH2 selective inhibitors inducing cell death in human leukemia U937 cells
Valente, Sergio; Di Santo, Roberto; Costi, Roberta; Mai, Antonello - 01a Articolo in rivista
paper: BIOCHIMIE (Editions Scientifique & Medical Elsevier:23 Rue Linois, F 75724 Paris Cedex 15 France:011 33 1 71724646, INTERNET: http://www.elsevier.fr, Fax: 011 33 1 71724664) pp. 2308-2313 - issn: 0300-9084 - wos: WOS:000310929200011 (22) - scopus: 2-s2.0-84867395419 (26)

11573/485036 - 2012 - Amino acid starvation induces reactivation of silenced transgenes and latent HIV-1 provirus via down-regulation of histone deacetylase 4 (HDAC4)
Valente, Sergio; Mai, Antonello - 01a Articolo in rivista
paper: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (National Academy of Sciences:2101 Constitution Avenue Northwest:Washington, DC 20418:(877)314-2253, (615)377-3322, EMAIL: subspnas@nas.edu, INTERNET: http://www.pnas.org, Fax: (615)377-0525) pp. E2284-E2293 - issn: 0027-8424 - wos: WOS:000308085200011 (30) - scopus: 2-s2.0-84865194183 (32)

11573/513460 - 2012 - Developing novel non-hydroxamate histone deacetylase inhibitors: the chelidamic warhead.
Valente, Sergio; Mai, Antonello - 01a Articolo in rivista
paper: MEDCHEMCOMM (Cambridge : Royal Society of Chemistry, 2010-) pp. 298-304 - issn: 2040-2503 - wos: WOS:000301966800004 (5) - scopus: 2-s2.0-84857707526 (5)

11573/525900 - 2012 - Aurones: Interesting Natural and Synthetic Compounds with Emerging Biological Potential
Zwergel, Clemens; Valente, Sergio - 01a Articolo in rivista
paper: NATURAL PRODUCT COMMUNICATIONS (Park Lane, Westerville, Usa : Natural Product, Inc. 7963) pp. 389-394 - issn: 1934-578X - wos: WOS:000301897900022 (55) - scopus: 2-s2.0-84860770231 (55)

11573/356064 - 2011 - Novel Cinnamyl Hydroxyamides and 2-Aminoanilides as Histone Deacetylase Inhibitors: Apoptotic Induction and Cytodifferentiation Activity
Valente, Sergio; Tardugno, Maria; Ragno, Rino; Simeoni, Silvia; Tramontano, Anna; Mai, Antonello - 01a Articolo in rivista
paper: CHEMMEDCHEM (Weinheim : Wiley-VCH-Verl..) pp. 698-712 - issn: 1860-7179 - wos: WOS:000288814900016 (14) - scopus: 2-s2.0-79953046146 (14)

11573/414595 - 2011 - Novel 3,5-bis(bromohydroxybenzylidene)piperidin-4-ones as coactivator-associated arginine methyltransferase 1 inhibitors: Enzyme selectivity and cellular activity
Valente, Sergio; Di Santo, Roberto; Costi, Roberta; Mai, Antonello - 01a Articolo in rivista
paper: JOURNAL OF MEDICINAL CHEMISTRY (Washington, DC: American Chemical Society) pp. 4928-4932 - issn: 0022-2623 - wos: WOS:000292479600049 (61) - scopus: 2-s2.0-79960191524 (67)

11573/436635 - 2011 - Novel Reversible Monoamine Oxidase A Inhibitors: Highly Potent and Selective 3-(1H-Pyrrol-3-yl)-2-oxazolidinones
Valente, Sergio; Tempera, Giampiero; Saccoccio, Stefania; Agostinelli, Enzo; Mai, Antonello - 01a Articolo in rivista
paper: JOURNAL OF MEDICINAL CHEMISTRY (Washington, DC: American Chemical Society) pp. 8228-8232 - issn: 0022-2623 - wos: WOS:000297445400024 (28) - scopus: 2-s2.0-82555187393 (28)

11573/443817 - 2011 - Application of 3 μm particle-based amylose-derived chiral stationary phases for the enantioseparation of potential histone deacetylase inhibitors.
Mai, Antonello; Valente, Sergio - 01a Articolo in rivista
paper: JOURNAL OF CHROMATOGRAPHY A (Elsevier BV:PO Box 211, 1000 AE Amsterdam Netherlands:011 31 20 4853757, 011 31 20 4853642, 011 31 20 4853641, EMAIL: nlinfo-f@elsevier.nl, INTERNET: http://www.elsevier.nl, Fax: 011 31 20 4853598) pp. 8394-8398 - issn: 0021-9673 - wos: WOS:000297036000012 (17) - scopus: 2-s2.0-80054874258 (18)

11573/525044 - 2011 - Histone deacetylase inhibitors (epigenetic alterations)Targeted Therapies for Hepatocellular Carcinoma
Valente, Sergio; Mai, Antonello - 02a Capitolo o Articolo
book: Targeted Therapies for Hepatocellular Carcinoma - (9781780840628)

11573/526018 - 2011 - Facile synthesis of 4-acetyl-coumarins, -thiocoumarin and -quinolin-2(1H)-one via very high α-regioselective Heck coupling on tosylates
Valente, Sergio - 01a Articolo in rivista
paper: TETRAHEDRON LETTERS (Oxford; New York; Paris; Frankfurt: Pergamon Press, 1959-) pp. 3429-3432 - issn: 0040-4039 - wos: WOS:000292413800005 (18) - scopus: 2-s2.0-79957940869 (18)

11573/229552 - 2010 - Nitric oxide determines mesodermic differentiation of mouse embryonic stem cells by activating class IIa histone deacetylases: potential therapeutic implications in a mouse model of hindlimb ischemia
Spallotta, Francesco; Rotili, Dante; Valente, Sergio; Mai, Antonello - 01a Articolo in rivista
paper: STEM CELLS (Alphamed Press Incorporated:1 Prestige Place, Suite 290:Miamisburg, OH 45342:(937)291-2355, EMAIL: alphamedpress@alphamedpress.com, INTERNET: http://www.alphamedpress.com, Fax: (937)291-4229) pp. 431-442 - issn: 1066-5099 - wos: WOS:000277093700006 (47) - scopus: 2-s2.0-77950581254 (46)

11573/365281 - 2010 - Biochemical, Structural, and Biological Evaluation of Tranylcypromine Derivatives as Inhibitors of Histone Demethylases LSD1 and LSD2
Valente, Sergio; Mai, Antonello - 01a Articolo in rivista
paper: JOURNAL OF THE AMERICAN CHEMICAL SOCIETY ([Washington, USA: American Chemical Society] 1879-) pp. 6827-6833 - issn: 0002-7863 - wos: WOS:000277721500044 (222) - scopus: 2-s2.0-77952355653 (235)

11573/434968 - 2010 - TNF/p38α/polycomb signaling to Pax7 locus in satellite cells links inflammation to the epigenetic control of muscle regeneration
Mozzetta, Chiara; Valente, Sergio; Mai, Antonello - 01a Articolo in rivista
paper: CELL STEM CELL (Cambridge: Cell Press (an imprint of Elsevier)) pp. 455-469 - issn: 1934-5909 - wos: WOS:000283270600008 (300) - scopus: 2-s2.0-77957357566 (319)

11573/434969 - 2010 - HDACs class II-selective inhibition alters nuclear receptor-dependent differentiation
Valente, Sergio; Rotili, Dante; Mai, Antonello - 01a Articolo in rivista
paper: JOURNAL OF MOLECULAR ENDOCRINOLOGY (Pubblicata da: SOC ENDOCRINOLOGY, 22 APEX COURT, WOODLANDS, BRADLEY STOKE, BRISTOL, ENGLAND, BS32 4JT primo editore: Journal of Endocrinology Limited:17 18 Courtyard Woodlands, Bristol BS12 4NQ United Kingdom:011 44 117 9616046, EMAIL: sxa15@psu.edu, INTERNET: http://www.psu.edu, Fax: 011 44 117 9616071) pp. 219-228 - issn: 0952-5041 - wos: WOS:000282528800005 (50) - scopus: 2-s2.0-77957824326 (53)

11573/443480 - 2010 - Synthesis and biological evaluation of novel coumarin-based inhibitors of Cdc25 phosphatases
Valente, Sergio - 01a Articolo in rivista
paper: BIOORGANIC & MEDICINAL CHEMISTRY LETTERS (Elsevier Science Limited:Oxford Fulfillment Center, PO Box 800, Kidlington Oxford OX5 1DX United Kingdom:011 44 1865 843000, 011 44 1865 843699, EMAIL: asianfo@elsevier.com, tcb@elsevier.co.UK, INTERNET: http://www.elsevier.com, http://www.elsevier.com/locate/shpsa/, Fax: 011 44 1865 843010) pp. 5827-5830 - issn: 0960-894X - wos: WOS:000281735600049 (35) - scopus: 2-s2.0-77957590019 (36)

11573/895420 - 2010 - Evaluation of histone deacetylases as drug targets in Huntington's disease models
Rotili, Dante; Valente, Sergio; Mai, Antonello - 02a Capitolo o Articolo
book: PLOS CURRENTS - ()

11573/12746 - 2009 - Pyrrole-Based Hydroxamates and 2-Aminoanilides: Histone Deacetylase Inhibition and Cellular Activities
Mai, Antonello; Valente, Sergio - 01a Articolo in rivista
paper: CHEMMEDCHEM (Weinheim : Wiley-VCH-Verl..) pp. 1411-1415 - issn: 1860-7179 - wos: WOS:000270027800002 (9) - scopus: 2-s2.0-69749113873 (9)

11573/12799 - 2009 - Study of 1,4-Dihydropyridine Structural Scaffold: Discovery of Novel Sirtuin Activators and Inhibitors
Mai, Antonello; Valente, Sergio - 01a Articolo in rivista
paper: JOURNAL OF MEDICINAL CHEMISTRY (Washington, DC: American Chemical Society) pp. 5496-5504 - issn: 0022-2623 - wos: WOS:000269655500022 (133) - scopus: 2-s2.0-69949096844 (140)

11573/13427 - 2009 - Histone post-translational modifications by HPLC-ESI-MS after HT29 cell treatment with HDAC inhibitors
Valente, Sergio; Mai, Antonello - 01a Articolo in rivista
paper: PROTEOMICS (Wiley-VCH Verlag GmBH:PO Box 101161, D 69451 Weinheim Germany:011 49 6201 606147, EMAIL: service@wiley-vch.de, INTERNET: http://www.wiley-vch.de, Fax: 011 49 6201 606328) pp. 5437-5445 - issn: 1615-9853 - wos: WOS:000273515000006 (20) - scopus: 2-s2.0-73149088831 (22)

11573/229211 - 2009 - New pyrrole-based histone deacetylase inhibitors: Binding mode, enzyme- and cell-based investigations
Mai, Antonello; Valente, Sergio; Simeoni, Silvia; Ragno, Rino - 01a Articolo in rivista
paper: THE INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY (Applied Science Publishers:Ripple Road, Barking Essex United Kingdom) pp. 235-247 - issn: 1357-2725 - wos: WOS:000262620400028 (23) - scopus: 2-s2.0-55949088703 (25)

11573/229551 - 2009 - Shock and kill" effects of class I-selective histone deacetylase inhibitors in combination with the glutathione synthesis inhibitor buthionine sulfoximine in cell line models for HIV-1 quiescence
Mai, Antonello; Valente, Sergio; Rotili, Dante; Palamara, Anna Teresa - 01a Articolo in rivista
paper: RETROVIROLOGY (London : BioMed Central) pp. 52-52 - issn: 1742-4690 - wos: WOS:000267430700001 (94) - scopus: 2-s2.0-67649259174 (94)

11573/434973 - 2009 - Selective class II HDAC inhibitors impair myogenesis by modulating the stability and activity of HDAC-MEF2 complexes.
Rotili, Dante; Valente, Sergio; Mai, Antonello - 01a Articolo in rivista
paper: EMBO REPORTS (Oxford : Oxford University Press, 2000-) pp. 776-782 - issn: 1469-221X - wos: WOS:000267599700022 (112) - scopus: 2-s2.0-67650083046 (116)

11573/442678 - 2009 - Histone deacetylase inhibitors and neurodegenerative disorders: Holding the promise
Mai, Antonello; Rotili, Dante; Valente, Sergio - 01a Articolo in rivista
paper: CURRENT PHARMACEUTICAL DESIGN (Bentham Science Publishers BV:PO Box 7917, Exec Ste Y 26, Saif Zone Sharjah Uae:011 971 6 5571132, EMAIL: benthams@emirates.net.ae, INTERNET: http://www.bentham.org, Fax: 011 971 6 5571134) pp. 3940-3957 - issn: 1381-6128 - wos: WOS:000271385600003 (67) - scopus: 2-s2.0-70649108817 (66)

11573/13144 - 2008 - HDAC-class II specific inhibition involves HDAC proteasome-dependent degradation mediated by RANBP2
Valente, Sergio; Mai, Antonello - 01a Articolo in rivista
paper: BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH (Elsevier BV:PO Box 211, 1000 AE Amsterdam Netherlands:011 31 20 4853757, 011 31 20 4853642, 011 31 20 4853641, EMAIL: nlinfo-f@elsevier.nl, INTERNET: http://www.elsevier.nl, Fax: 011 31 20 4853598) pp. 2030-2038 - issn: 0167-4889 - wos: WOS:000259917200036 (45) - scopus: 2-s2.0-50849143144 (47)

11573/13369 - 2008 - Specific Activity of Class II Histone Deacetylases in Human Breast Cancer Cells
Mai, Antonello; Valente, Sergio - 01a Articolo in rivista
paper: MOLECULAR CANCER RESEARCH (American Association of Cancer Research:150 South Independence Mall West, #826:Philadelphia, PA 19106:(215)440-9300, EMAIL: pubs@aacr.org, INTERNET: http://www.aacr.org, Fax: (215)440-7228) pp. 1908-1919 - issn: 1541-7786 - wos: WOS:000261824800011 (77) - scopus: 2-s2.0-57749101152 (85)

11573/13425 - 2008 - Epigenetric Multiple Ligands: Mixed Histone/Protein Methyltransferase, Acetyltransferase, and Class III Deacetylase (Sirtuin) Inhibitors
Mai, Antonello; Valente, Sergio; Sbardella, Gianluca - 01a Articolo in rivista
paper: JOURNAL OF MEDICINAL CHEMISTRY (Washington, DC: American Chemical Society) pp. 2279-2290 - issn: 0022-2623 - wos: WOS:000254709100033 (119) - scopus: 2-s2.0-41849146748 (125)

11573/358405 - 2008 - Nitric oxide modulates chromatin folding in human endothelial cells via protein phosphatase 2A activation and class II histone deacetylases nuclear shuttling
Spallotta, Francesco; Rotili, Dante; Valente, Sergio; Mai, Antonello - 01a Articolo in rivista
paper: CIRCULATION RESEARCH (Lippincott, Williams & Wilkins:530 Walnut Street:Philadelphia, PA 19106:(800)638-3030, (301)223-2300, EMAIL: orders@lww.com, INTERNET: http://www.lww.com, Fax: (301)223-2320, (301)223-2320 PRimo editore: Baltimore, Md. : Grune & Stratton, c1953-) pp. 51-58 - issn: 0009-7330 - wos: WOS:000252217400009 (93) - scopus: 2-s2.0-37849010584 (97)

11573/363936 - 2008 - Novel uracil-based 2-aminoanilide and 2-aminoanilide-like derivatives: Histone deacetylase inhibition and in-cell activities
Mai, Antonello; Rotili, Dante; Valente, Sergio - 01a Articolo in rivista
paper: BIOORGANIC & MEDICINAL CHEMISTRY LETTERS (Elsevier Science Limited:Oxford Fulfillment Center, PO Box 800, Kidlington Oxford OX5 1DX United Kingdom:011 44 1865 843000, 011 44 1865 843699, EMAIL: asianfo@elsevier.com, tcb@elsevier.co.UK, INTERNET: http://www.elsevier.com, http://www.elsevier.com/locate/shpsa/, Fax: 011 44 1865 843010) pp. 2530-2535 - issn: 0960-894X - wos: WOS:000255246400002 (20) - scopus: 2-s2.0-41849089386 (24)

11573/240206 - 2007 - Synthesis and biological validation of novel synthetic histone/protein methyltransferase inhibitors
Mai, Antonello; Valente, Sergio; Ragno, Rino; Simeoni, Silvia - 01a Articolo in rivista
paper: CHEMMEDCHEM (Weinheim : Wiley-VCH-Verl..) pp. 987-991 - issn: 1860-7179 - wos: WOS:000248065600003 (51) - scopus: 2-s2.0-41849112166 (50)

11573/362130 - 2007 - Identification of two new synthetic histone deacetylase inhibitors that modulate globin gene expression in erythroid cells from healthy donors and patients with thalassemia
Mai, Antonello; Rotili, Dante; Valente, Sergio - 01a Articolo in rivista
paper: MOLECULAR PHARMACOLOGY (American Society for Pharmacology and Experimental Therapeutics:9650 Rockville Pike:Bethesda, MD 20814:(301)530-7024, EMAIL: pstoute@aspet.org, INTERNET: http://www.aspet.org, Fax: (301)634-7099) pp. 1111-1123 - issn: 0026-895X - wos: WOS:000250385300004 (29) - scopus: 2-s2.0-35548933854 (30)

11573/364545 - 2007 - Novel pyrrole-containing histone deacetylase inhibitors endowed with cytodifferentiation activity
Mai, Antonello; Valente, Sergio; Rotili, Dante - 01a Articolo in rivista
paper: THE INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY (Applied Science Publishers:Ripple Road, Barking Essex United Kingdom) pp. 1510-1522 - issn: 1357-2725 - wos: WOS:000248566700025 (14) - scopus: 2-s2.0-34447268739 (14)

11573/51660 - 2007 - New Aroyl-Pyrrolyl-Hydroxy-Amides APHAs: Class I and II Histone Deacetylase Inhibiting Activity and Binding Mode Analysis through Molecular Docking Experiments
Ragno, Rino; Mai, Antonello; Valente, Sergio - 04a Atto di comunicazione a congresso
conference: Frontiers in CNS and Oncology Medicinal Chemistry, ACS-EFMC (Siena, Italy)
book: Frontiers in CNS and Oncology Medicinal Chemistry, ACS-EFMC - ()

11573/234238 - 2006 - Aroyl-pyrrolyl hydroxyamides: Influence of pyrrole C4-phenylacetyl substitution on histone deacetylase inhibition
Mai, Antonello; Valente, Sergio; Ragno, Rino - 01a Articolo in rivista
paper: CHEMMEDCHEM (Weinheim : Wiley-VCH-Verl..) pp. 225-237 - issn: 1860-7179 - wos: WOS:000202945600008 (21) - scopus: 2-s2.0-33646483786 (22)

11573/234818 - 2006 - 3-D QSAR Studies on Histone Deacetylase Inhibitors. A GOLPE/GRID Approach on Different Series of Compounds.
Ragno, Rino; Valente, Sergio; Mai, Antonello - 01a Articolo in rivista
paper: JOURNAL OF CHEMICAL INFORMATION AND MODELING (AMER CHEMICAL SOC, 1155 16TH ST, NW, WASHINGTON, USA, DC, 20036) pp. 1420-1430 - issn: 1549-9596 - wos: WOS:000237658400053 (40) - scopus: 2-s2.0-33745356936 (44)

11573/13036 - 2005 - Synthesis and biological evaluation of 2-, 3-, and 4-acylaminocinnamyl-N-hydroxyamides as novel synthetic HDAC inhibitors.
Mai, Antonello; Valente, Sergio - 01a Articolo in rivista
paper: MEDICINAL CHEMISTRY (Bentham Science Publishers Ltd) pp. 245-254 - issn: 1573-4064 - wos: (0) - scopus: 2-s2.0-25144492801 (26)

11573/365771 - 2005 - 3-(1H-Pyrrol-2-yl)-2-oxazolidinones as novel monoamine oxidase type A inhibitors.
Mai, Antonello; Artico, Marino; Valente, Sergio; Sbardella, Gianluca; Turini, Paola; Befani, Olivia; Agostinelli, Enzo - 01a Articolo in rivista
paper: MEDICINAL CHEMISTRY (Bentham Science Publishers Ltd) pp. 117-124 - issn: 1573-4064 - wos: (0) - scopus: 2-s2.0-33846116762 (6)

11573/526020 - 2005 - Histone Deacetylation in Epigenetics: An Attractive Target for Anticancer Therapy
Mai, Antonello; Rotili, Dante; Valente, Sergio; Ragno, Rino - 01a Articolo in rivista
paper: MEDICINAL RESEARCH REVIEWS (John Wiley & Sons Incorporated:Customer Service, 111 River Street:Hoboken, NJ 07030:(800)225-5945, (201)748-6000, EMAIL: societyinfo@wiley.com, INTERNET: http://www.wiley.com, Fax: (212)748-6551) pp. 261-309 - issn: 0198-6325 - wos: WOS:000228224900001 (292) - scopus: 2-s2.0-16844362441 (305)

11573/13659 - 2004 - Antimalarial and Antileishmanial Activities of Aroyl-pyrrolyl-hydroxy-amides, a New Class of Histone Deacetylase Inhibitors
Mai, Antonello; Valente, Sergio - 01a Articolo in rivista
paper: ANTIMICROBIAL AGENTS AND CHEMOTHERAPY (American Society for Microbiology:PO Box 11127:Birmingham, AL 35201:(800)633-4931, (205)995-1567, EMAIL: asm.nonmembers.subs@ebsco.com, INTERNET: http://www.asm.org, Fax: (205)995-1588) pp. 1435-1436 - issn: 0066-4804 - wos: WOS:000220658600060 (49) - scopus: 2-s2.0-1642460965 (50)

11573/234811 - 2004 - 3-(4-Aroyl-1-methyl-1H-2-pyrrolyl)-N-hydroxy-2-propenamides as a New Class of Synthetic Histone Deacetylase Inhibitors. 2. Effect of Pyrrole-C2 and/or -C4 Substitutions on Biological Activity
Mai, Antonello; Valente, Sergio; Ragno, Rino - 01a Articolo in rivista
paper: JOURNAL OF MEDICINAL CHEMISTRY (Washington, DC: American Chemical Society) pp. 1098-1109 - issn: 0022-2623 - wos: WOS:000189151500005 (59) - scopus: 2-s2.0-1242273835 (66)

11573/240328 - 2004 - Synthesis and biochemical evaluation of (R)-5-acyloxymethyl- and (S)-5-acylaminomethyl-3-(1H-pyrrol-1-yl)-2-oxazolidinones as new anti-monoamine oxidase (anti-MAO) agents.
Mai, Antonello; Artico, Marino; Valente, Sergio; Befani, Olivia; Turini, Paola; Agostinelli, Enzo - 01a Articolo in rivista
paper: ARKIVOC (ARKAT USA INC, C/O ALAN R KATRITZKY, UNIV FLORIDA, DEPT CHEMISTRY, PO BOX 117200, GAINESVILLE, USA, FL, 32611) pp. 23-43 - issn: 1551-7004 - wos: WOS:000222493900004 (6) - scopus: (0)

11573/434777 - 2004 - 3-(4-Aroyl-1-methyl-1H-pyrrol-2-yl)-N-hydroxy-2-propenamides as a new class of synthetic histone deacetylase inhibitors. 3. Discovery of novel lead compounds through structure-based drug design and docking studies.
Ragno, Rino; Mai, Antonello; Valente, Sergio - 01a Articolo in rivista
paper: JOURNAL OF MEDICINAL CHEMISTRY (Washington, DC: American Chemical Society) pp. - - issn: 0022-2623 - wos: WOS:000220038700008 (64) - scopus: 2-s2.0-12144291023 (69)

11573/204734 - 2003 - 3-(1H-pyrrol-2- and –3-yl)-2-oxazolidinones as novel potent and selective monoamine oxidase type A inhibitors.
Mai, Antonello; Valente, Sergio; Artico, Marino; Befani, Olivia; Turini, Paola; Agostinelli, Enzo - 04a Atto di comunicazione a congresso
book: 8th International Congress on Amino Acids and Proteins - ()

11573/218667 - 2003 - 3-(1H-pyrrol-2- and –3-yl)-2-oxazolidinones as novel potent and selective monoamine oxidase type A inhibitors.
Mai, Antonello; Valente, Sergio; Artico, Marino; Befani, Olivia; Turini, Paola; Agostinelli, Enzo - 13a Altro ministeriale

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