ALESSIA FIORE

PhD Graduate

PhD program:: XXXVII


supervisor: Prof. Alessia Fabbri (ISS)

Thesis title: The bacterial toxin CNF1 and its potential role in promoting colorectal cancer: a preclinical study

Bacterial toxins are emerging as promising hallmarks of colorectal cancer (CRC) pathogenesis. In particular, Cytotoxic Necrotizing Factor 1 (CNF1) from E. coli deserves special consideration due to the significantly higher prevalence of this toxin gene in CRC patients with respect to healthy subjects, and to the numerous tumor-promoting effects that have been ascribed to the toxin in vitro. Despite this evidence, a definitive causal link between CNF1 and CRC was missing. Here we investigated whether CNF1 plays an active role in CRC onset by analyzing pro-carcinogenic key effects specifically induced by the toxin in vitro and in vivo.

Research products

11573/1756042 - 2025 - Isolation and phenotype analysis of tissue-resident lymphocytes from mouse colon
Fiore, A.; Tozzi, M.; Rinzo, P.; Macchia, D.; Spada, M.; Fabbri, A.; Bracci, L. - 01a Articolo in rivista
paper: METHODS IN CELL BIOLOGY (Academic Press Incorporated:6277 Sea Harbor Drive:Orlando, FL 32887:(800)543-9534, (407)345-4100, EMAIL: ap@acad.com, INTERNET: http://www.idealibrary.com, Fax: (407)352-3445) pp. 187-199 - issn: 0091-679X - wos: (0) - scopus: 2-s2.0-105000347968 (0)

11573/1756051 - 2025 - The bacterial toxin CNF1 accelerates colorectal cancer progression and metastatic spread
Laterza, Ilenia; Tozzi, Michela; Angela Pia Germinario, Elena; Travaglione, Sara; Fiore, Alessia; Gambardella, Lucrezia; Rossi, Stefania; Michelini, Zuleika; Cara, Andrea; Maroccia, Zaira; Tomasoni, Sofia; Verin, Ranieri; Leoni, Omar; De Luca, Gabriele; Spada, Massimo; Khoueiry, Rita; Herceg, Zdenko; Biffoni, Mauro; Bracci, Laura; Fabbri, Alessia - 04f Poster
conference: 10° ACC annual meeting-New technologies and strategies to fight cancer (Verona)
book: Alleanza Contro il Cancro (ACC) - ()

11573/1756043 - 2025 - E. Coli cytotoxic necrotizing factor-1 promotes colorectal carcinogenesis by causing oxidative stress, DNA damage and intestinal permeability alteration
Tozzi, Michela; Fiore, Alessia; Travaglione, Sara; Marcon, Francesca; Rainaldi, Gabriella; Angela Pia Germinario, Elena; Laterza, Ilenia; Donati, Simona; Macchia, Daniele; Spada, Massimo; Leoni, Omar; Cristina Quattrini, Maria; Pietraforte, Donatella; Tomasoni, Sofia; Torrigiani, Filippo; Verin, Ranieri; Matarrese, Paola; Gambardella, Lucrezia; Spadaro, Francesca; Carollo, Maria; Pietrantoni, Agostina; Carlini, Francesca; Panebianco, Concetta; Pazienza, Valerio; Colella, Filomena; Lucchetti, Donatella; Sgambato, Alessandro; Sistigu, Antonella; Moschella, Federica; Guidotti, Marco; Vincentini, Olimpia; Maroccia, Zaira; Biffoni, Mauro; De Angelis, Roberta; Bracci, Laura; Fabbri, Alessia - 01a Articolo in rivista
paper: JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH (London : BioMed Central) pp. - - issn: 1756-9966 - wos: WOS:001409654400001 (5) - scopus: 2-s2.0-85217272611 (5)

11573/1756049 - 2024 - The bacterial toxin CNF1 drives CRC progression though the induction of cellular senescence and stemness features
Laterza, Ilenia; Angela Pia Germinario, Elena; Fiori, Micol E.; Fiore, Alessia; Tozzi, Michela; Maroccia, Zaira; Travaglione, Sara; Bracci, Laura; Fabbri, Alessia - 04f Poster
conference: 36° AICC International Meeting 2024 HIJACKING THE <> PATHWAYS: CANCER, IMMUNITY AND THERAPEUTIC APPROACHES (Roma)
book: Associazione Italiana colture cellulari (AICC) - ()

11573/1756047 - 2024 - The bacterial toxin CNF1 as a driver of progression in colorectal cancer: a preclinical study
Laterza, Ilenia; Angela Pia Germinario, Elena; Tozzi, Michela; Travaglione, Sara; Fiore, Alessia; Khoueiry, Rita; Herceg, Zdenko; Gambardella, Lucrezia; Maroccia, Zaira; Macchia, Daniele; Spada, Massimo; Bracci And Alessia Fabbri, Laura - 04f Poster
conference: 9° ACC annual meeting-New technologies and strategies to fight cancer (Reggio Emilia)
book: Alleanza Contro il Cancro (ACC) - ()

11573/1756048 - 2024 - CNF1 from E. coli favors colorectal cancer development and progression
Tozzi, Michela; Fiore, Alessia; Laterza, Ilenia; Rinzo, Paola; Donati, Simona; Travaglione, Sara; Angela Pia Germinario2, Elena; Leoni, Omar; Macchia, Daniele; Spada, Massimo; Tomasoni, Sofia; Verin, Ranieri; Colella, Filomena; Lucchetti, Donatella; Sistigu, Antonella; Maroccia, Zaira; Fabbri And Laura Bracci, Alessia - 04f Poster
conference: AICC- Associazione Italiana Colture Cellulari (Roma)
book: AICC - ()

11573/1756052 - 2024 - CNF1 toxin from E.coli induces oxidative DNA damage, intestinal permeability and colorectal neoplasia in vivo
Tozzi, Michela; Fiore, Alessia; Travaglione, Sara; Rainaldi, Gabriella; Laterza, Ilenia; Donati, Simona; Gambardella, Lucrezia; Marcon4, Francesca; Pietraforte, Donatella; Cristina Quattrini, Maria; Vincentini, Olimpia; Spadaro, Francesca; Carollo, Maria; Macchia, Daniele; Spada, Massimo; Tommasoni, Sofia; Verin, Ranieri; De Angelis, Roberta; Fabbri And Laura Bracci, Alessia - 04f Poster
conference: ACC - Alleanza contro il cancro (Reggio Emilia)
book: ACC - ()

11573/1646140 - 2022 - Circulating U13 Small Nucleolar RNA as a Potential Biomarker in Huntington’s Disease: A Pilot Study
Romano, Silvia; Romano, Carmela; Peconi, Martina; Fiore, Alessia; Bellucci, Gianmarco; Morena, Emanuele; Troili, Fernanda; Cipollini, Virginia; Annibali, Viviana; Giglio, Simona; Mechelli, Rosella; Ferraldeschi, Michela; Veneziano, Liana; Mantuano, Elide; Sani, Gabriele; Vecchione, Andrea; Umeton, Renato; Giubilei, Franco; Salvetti, Marco; Corbo, Rosa Maria; Scarabino, Daniela; Ristori, Giovanni - 01a Articolo in rivista
paper: INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (Basel (Matthaeustrasse 11) : Molecular Diversity Preservation International MDPI) pp. 12440- - issn: 1661-6596 - wos: WOS:000873041100001 (8) - scopus: 2-s2.0-85140829236 (9)

11573/1693891 - 2022 - Circulating U13 small nucleolar RNA as a candidate biomarker for Huntington's disease: A Pilot Study
Romano, Silvia; Romano, Carmela; Peconi, Martina; Fiore, Alessia; Bellucci, Gianmarco; Morena, Emanuele; Troili, Fernanda; Cipollini, Virginia; Annibali, Viviana; Giglio, Simona; Mechelli, Rosella; Ferraldeschi, Michela; Veneziano, Liana; Mantuano, Elide; Sani, Gabriele; Vecchione, Andrea; Umeton, Renato; Giubilei, Franco; Salvetti, Marco; Corbo, Rosa Maria; Scarabino, Daniela; Ristori, Giovanni - 01a Articolo in rivista
paper: INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (Basel: MDPI Center) pp. - - issn: 1422-0067 - wos: (0) - scopus: (0)

© Università degli Studi di Roma "La Sapienza" - Piazzale Aldo Moro 5, 00185 Roma