ALESSANDRO ROSA

Associate professor


email: alessandro.rosa@uniroma1.it
phone:
building: CU026
room: 32

RESEARCHER IDENTIFIERS

ORCID ID: 0000-0001-9999-7223
Scopus Author ID: 9638433400
Researcher ID: A-3860-2012

EDUCATION/QUALIFICATIONS

Since Jan. 2020: National Scientific Qualification for Full Professor (Abilitazione Scientifica Nazionale per la Prima Fascia). S.C. 05/E2 Biologia Molecolare (sector: Molecular Biology)

Since Nov. 2019: Associate Professor. Department of Biology and Biotechnology “Charles Darwin”, Sapienza University, Rome, Italy.

Since 2017 Affiliated researcher. Istituto Italiano di Tecnologia IIT@Sapienza. Center for Life Nanoscience - CLNS

Since 2014: Member of the Adjunct Faculty (2014-2019) and Guest Investigator (since 2019). The Rockefeller University, New York, USA.

Dec. 2011-Oct. 2019: Assistant Professor. Department of Biology and Biotechnology “Charles Darwin”, Sapienza University, Rome, Italy.

Nov. 2010-Nov. 2011: Postdoctoral Fellow. Department of Biology and Biotechnology “Charles Darwin”, Sapienza University, Rome, Italy.

June 2009-Oct 2010: Director of the Rockefeller University Stem Cell Derivation Core. Center for the derivation of human embryonic stem cell (hESC) and human induced pluripotent stem cell (hiPS) lines with a normal as well as diseased genetic background.

April 2008-Nov. 2011: Long term Human Frontier Science Program (HFSP) fellowship.

May 2007-Oct 2010: Postdoctoral Associate. Laboratory of Stem Cell Biology and Molecular Embryology (Brivanlou Lab). The Rockefeller University, New York, USA.

Jan.-April 2007: Short term Institute Pasteur - Fondazione Cenci-Bolognetti fellowship. Department of Genetics and Molecular Biology, Sapienza University, Rome, Italy.

Feb. 28, 2007: PhD Degree in Genetics and Molecular Biology with the thesis: “Rescue of dystrophin synthesis and body-wide muscle function in mdx dystrophic mice by antisense-snRNA mediated exon-skipping”.

Nov. 2003-Feb. 2007: PhD Course in Genetics and Molecular Biology. Department of Genetics and Molecular Biology, Sapienza University, Rome, Italy.

July 17, 2003 Graduated with honours (110/110 cum laude) in Biological Sciences with the Thesis “RNA interference in cellule di mammifero: costruzione di nuovi vettori per l'espressione stabile di siRNA” (“RNA interference in mammalian cells: construction of new vectors for the stable expression of siRNAs”).

Nov. 1998-July 2003: Sciences Faculty, Sapienza University, Rome, Italy.Course in Biological Sciences (Molecular Biology section).


PROFESSIONAL AND RESEARCH EXPERIENCE

Awards

• Acknowledgement for the excellence in University teaching 2017-18 and 2020-21. Awarded by the Faculty of Sciences of the Sapienza University to the top 5% of the teachers.
• PNI (National Prize for Innovation, Italy) 2017: special award for Best Project for Equal Opportunities - startup project HoMoLoG.
• 1st Award at the business plan competition StartCup Lazio 2017 - startup project HoMoLoG.
• Winner of the Bioeconomy Rome 2012 Award “For the most innovative Italian intuitions of 2011 in the field of biomedical sciences”. Awarded by CNCCS (Collezione Nazionale di Composti Chimici e Centro Screening).
• Winner of the RNA Society 2008 poster award in the category “Genetics and Development”.
• Winner of a post-doctoral fellowship “Long term 2008 Human Frontier Science Program (HFSP)”.
• Winner of a post-doctoral fellowship “The New York Stem Cell Foundation (NYSCF)” (2008). The fellowship was declined by the candidate in favor of the “Long term 2008 Human Frontier Science Program (HFSP)”.
• Winner of the 2006 SIBBM (Italian Society of Biophysics and Molecular Biology) Award.

Full list of Publications available in ORCID: https://orcid.org/0000-0001-9999-7223

65 papers indexed in Scopus and/or WOS

Hirsch Index (H-Index): 24 (Scopus)


Patents

RM2007A000595
Title: Use of miRNA and siRNA in therapy
Inventors: Irene Bozzoni, Alessandro Fatica, Alessandro Rosa
Dep. 15-11-2007

RM2003A000335 (Foreign Ext. PCT/IT04/00038)
Title: Construction of a new vector for siRNA in vivo expression
Inventors: Irene Bozzoni, Michela Denti, Alessandro Rosa
Dep. 9-7-2003
Patent licensed to Promega Corporation for the commercialization of the product GeneClip™ U1 Hairpin Cloning Systems.

Grants as PI
2021-2022 Regione Lazio - POR FESR LAZIO 2014-2020 “PROGETTI DI GRUPPI DI RICERCA 2020”. Soluzione Integrata di Microscopia Brillouin Avanzata (SIMBA) (project number: A0375-2020-36389)
2019-2021 Istituto Pasteur Italia - Fondazione Cenci Bolognetti. Call for projects 2019. Study of the role of RNA-binding proteins in the neurodegenerative disease Amyotrophic Lateral Sclerosis
2019-2021 Sapienza University “Progetto di Ateneo” 2018. Identification and characterization of RNA binding proteins and non-coding RNAs with a role in human neural specification and neurodegenerative diseases.
2017-2018 AriSLA Pilot Grant 2016. StressFUS - Impairment of the stress response by mutant FUS in iPSC-derived human ALS motoneurons.
2015-2016 Sapienza University “Progetto di Ateneo” 2015. Study of pathways affected by mutations in the FUS gene in an iPSC-based ALS model system.
2014-2015 Sapienza University “Progetto di Ateneo” 2014. Identification of interactors of long non-coding RNAs involved in cell differentiation.

Organization of scientific meetings
2019-2021: International Winter School on Molecular Medicine. Sapienza University of Rome, Italy.
2012 and 2016: Coordinator of the “Stem Cells, iPS, Cancer Stem Cells” minisymposium. FISV(Italian Federation of Life Sciences) Meeting, Italy.

Editorial activity
Associate Editor of Stem Cell Research (specialty section of Frontiers in Cell and Developmental Biology, Frontiers in Genetics, Frontiers in Oncology and Frontiers in Bioengineering and Biotechnology).
Editor of Stem Cells International (Hindawi Publishing Corporation; E-ISSN:1687-9678).
Guest Editor for a special issue on “The RNA revolution in embryonic development and cell differentiation in health and disease”. Frontiers in Cell and Developmental Biology.

About 30 oral presentations in national or international conferences

Research products

11573/1668400 - 2023 - Digital color-coded molecular barcoding reveals dysregulation of common FUS and FMRP targets in soma and neurites of ALS mutant motoneurons
Garone, Maria Giovanna; Salerno, Debora; Rosa, Alessandro - 01a Articolo in rivista
paper: CELL DEATH DISCOVERY ([London]: Nature Publishing Group, 2015-) pp. - - issn: 2058-7716 - wos: WOS:000920816800001 (0) - scopus: 2-s2.0-85146766524 (0)

11573/1670054 - 2023 - AurkA nuclear localization is promoted by TPX2 and counteracted by protein degradation
Polverino, Federica; Mastrangelo, Anna; Rosa, Alessandro; Paiardini, Alessandro; Guarguaglini, Giulia - 01a Articolo in rivista
paper: LIFE SCIENCE ALLIANCE ([Woodbury NY]: Life Science Alliance LLC, [2018]-) pp. - - issn: 2575-1077 - wos: (0) - scopus: 2-s2.0-85148256341 (0)

11573/1645416 - 2022 - Culture of Human iPSC-Derived Motoneurons in Compartmentalized Microfluidic Devices and Quantitative Assays for Studying Axonal Phenotypes
Garone, Maria Giovanna; D'antoni, Chiara; Rosa, Alessandro - 02a Capitolo o Articolo
book: Methods in Molecular Biology - (978-1-0716-1978-0; 978-1-0716-1979-7)

11573/1651174 - 2022 - Upregulation of β-catenin due to loss of miR-139 contributes to motor neuron death in amyotrophic lateral sclerosis
Rosa, Alessandro - 01a Articolo in rivista
paper: STEM CELL REPORTS (Amsterdam : Elsevier) pp. 1650-1665 - issn: 2213-6711 - wos: WOS:000827571800003 (1) - scopus: 2-s2.0-85133974937 (2)

11573/1652462 - 2022 - Inducible motor neuron differentiation of human induced pluripotent stem cells in vivo
Rosa, Alessandro - 01a Articolo in rivista
paper: CELL PROLIFERATION (Blackwell Science Limited:PO Box 88, Oxford OX2 0NE United Kingdom:011 44 1865 776868, 011 44 1865 206038, EMAIL: journals.cs@blacksci.co.uk, INTERNET: http://www.blackwell-science.com, Fax: 011 44 1865 721205) pp. - - issn: 0960-7722 - wos: WOS:000837703700001 (1) - scopus: 2-s2.0-85135558919 (1)

11573/1660709 - 2022 - Modelling skeletal pain harnessing tissue engineering
Benedetti, Maria Cristina; Donsante, Samantha; Rosa, Alessandro; Corsi, Alessandro; Riminucci, Mara; Ruocco, Giancarlo; Scognamiglio, Chiara - 01a Articolo in rivista
paper: IN VITRO MODELS (Cham: Springer) pp. 289-307 - issn: 2731-3433 - wos: (0) - scopus: (0)

11573/1662787 - 2022 - Emerging roles for the RNA-Binding protein HuD (ELAVL4) in nervous system diseases
Silvestri, Beatrice; Mochi, Michela; Garone, Maria Giovanna; Rosa, Alessandro - 01g Articolo di rassegna (Review)
paper: INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (Basel: MDPI Center) pp. - - issn: 1422-0067 - wos: WOS:000896194600001 (1) - scopus: 2-s2.0-85143789148 (1)

11573/1549009 - 2021 - Novel fragile X syndrome 2D and 3D brain models based on human isogenic FMRP-KO iPSCs
Salaris, Federico; Cordella, Federica; Ghirga, Silvia; Rosito, Maria; D'antoni, Chiara; Rosa, Alessandro; Di Angelantonio, Silvia - 01a Articolo in rivista
paper: CELL DEATH & DISEASE (Nature Group) pp. 1-22 - issn: 2041-4889 - wos: WOS:000656273400004 (19) - scopus: 2-s2.0-85105917597 (20)

11573/1549404 - 2021 - Small heat-shock protein HSPB3 promotes myogenesis by regulating the lamin B receptor
Garone, Maria Giovanna; Silvestri, Beatrice; Rosa, Alessandro - 01a Articolo in rivista
paper: CELL DEATH & DISEASE (Nature Group) pp. 1-19 - issn: 2041-4889 - wos: WOS:000656257000003 (8) - scopus: 2-s2.0-85105454628 (8)

11573/1564033 - 2021 - FUS-ALS mutants alter FMRP phase separation equilibrium and impair protein translation
Garone, Maria Giovanna; Rosa, Alessandro - 01a Articolo in rivista
paper: SCIENCE ADVANCES (Washington, DC : American Association for the Advancement of Science, 2015-) pp. 1-16 - issn: 2375-2548 - wos: WOS:000675849000015 (12) - scopus: 2-s2.0-85110283030 (11)

11573/1567941 - 2021 - ALS-related FUS mutations alter axon growth in motoneurons and affect HuD/ELAVL4 and FMRP activity
Garone, Maria Giovanna; Rosito, Maria; Salaris, Federico; Mochi, Michela; De Turris, Valeria; Morlando, Mariangela; Rosa, Alessandro - 01a Articolo in rivista
paper: COMMUNICATIONS BIOLOGY ([London]: Springer Nature) pp. 1025- - issn: 2399-3642 - wos: WOS:000692407000006 (7) - scopus: 2-s2.0-85114160672 (8)

11573/1575596 - 2021 - Editorial: The RNA Revolution in Embryonic Development and Cell Differentiation in Health and Disease
Rosa, Alessandro; Fazi, Francesco - 01m Editorial/Introduzione in rivista
paper: FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY (Lausanne : Frontiers Media S.A., 2013-) pp. 1-3 - issn: 2296-634X - wos: WOS:000704152300001 (0) - scopus: 2-s2.0-85115924721 (0)

11573/1593905 - 2021 - Single-cell transcriptomics identifies master regulators of neurodegeneration in SOD1 ALS iPSC-derived motor neurons
Rosa, Alessandro - 01a Articolo in rivista
paper: STEM CELL REPORTS (Amsterdam : Elsevier) pp. 3020-3035 - issn: 2213-6711 - wos: WOS:000731607400003 (1) - scopus: 2-s2.0-85120974608 (1)

11573/1601513 - 2021 - A computational approach to investigate tdp-43 rna-recognition motif 2 c-terminal fragments aggregation in amyotrophic lateral sclerosis
Grassmann, Greta; Miotto, Mattia; Di Rienzo, Lorenzo; Salaris, Federico; Silvestri, Beatrice; Rosa, Alessandro; Tartaglia, Gian Gaetano; Ruocco, Giancarlo; Milanetti, Edoardo - 01a Articolo in rivista
paper: BIOMOLECULES (Basel: MDPI) pp. 1905- - issn: 2218-273X - wos: WOS:000736331100001 (2) - scopus: 2-s2.0-85121301369 (2)

11573/1631026 - 2021 - PiggyBac vectors in pluripotent stem cell research and applications
Garone, Maria Giovanna; Rosa, Alessandro - 02a Capitolo o Articolo
book: Methods in iPSC Technology - (9780323857666)

11573/1367089 - 2020 - Excess TPX2 interferes with microtubule disassembly and nuclei reformation at mitotic exit
Naso, Francesco Davide; Crecca, Elena; Rosa, Alessandro - 01a Articolo in rivista
paper: CELLS (Basel: mdpi-Molecular Diversity Preservation International) pp. 1-21 - issn: 2073-4409 - wos: WOS:000521944900115 (10) - scopus: 2-s2.0-85087951198 (10)

11573/1387940 - 2020 - Establishment of an in Vitro Human Blood-Brain Barrier Model Derived from Induced Pluripotent Stem Cells and Comparison to a Porcine Cell-Based System
Rosa, Alessandro - 01a Articolo in rivista
paper: CELLS (Basel: mdpi-Molecular Diversity Preservation International) pp. - - issn: 2073-4409 - wos: WOS:000535559500205 (15) - scopus: 2-s2.0-85083871349 (17)

11573/1391093 - 2020 - Acute conversion of patient-derived Duchenne muscular dystrophy iPSC into myotubes reveals constitutive and inducible over-activation of TGFβ-dependent pro-fibrotic signaling
Rosa, Alessandro - 01a Articolo in rivista
paper: SKELETAL MUSCLE (London : BioMed Central) pp. - - issn: 2044-5040 - wos: WOS:000531624500001 (15) - scopus: 2-s2.0-85084308600 (15)

11573/1405967 - 2020 - FUS ALS-causative mutations impair FUS autoregulation and splicing factor networks through intron retention
Garone, Maria Giovanna; Rosa, Alessandro; Bozzoni, Irene - 01a Articolo in rivista
paper: NUCLEIC ACIDS RESEARCH (Oxford University Press:Journals Department, Great Clarendon Street, Oxford OX2 6DP United Kingdom:011 44 1865 556767, EMAIL: jnlorders@oup.co.uk, INTERNET: http://www.oup.co.uk, Fax: 011 44 1865 267485 Editore precedente: Information Retrieval ltd., London) pp. - - issn: 0305-1048 - wos: WOS:000574288800041 (30) - scopus: 2-s2.0-85088208506 (32)

11573/1427982 - 2020 - Trans-generational epigenetic regulation associated with the amelioration of Duchenne Muscular Dystrophy
Martone, Julie; Lisi, Michela; Castagnetti, Francesco; Rosa, Alessandro; Di Carlo, Valerio; Setti, Adriano; Mariani, Davide; Colantoni, Alessio; Santini, Tiziana; Perone, Leonardo; Bozzoni, Irene - 01a Articolo in rivista
paper: EMBO MOLECULAR MEDICINE (Chichester : Wiley-Blackwell, 2009-) pp. - - issn: 1757-4676 - wos: WOS:000543752000001 (8) - scopus: 2-s2.0-85087294308 (7)

11573/1429819 - 2020 - HOTAIRM1 regulates neuronal differentiation by modulating NEUROGENIN 2 and the downstream neurogenic cascade
Rea, Jessica; Menci, Valentina; Tollis, Paolo; Santini, Tiziana; Garone, Maria Giovanna; Cipriano, Andrea; Tartaglia, Gian Gaetano; Rosa, Alessandro; Ballarino, Monica; Laneve, Pietro; Caffarelli, Elisa - 01a Articolo in rivista
paper: CELL DEATH & DISEASE (Nature Group) pp. - - issn: 2041-4889 - wos: WOS:000553100400002 (13) - scopus: 2-s2.0-85087954274 (15)

11573/1430664 - 2020 - Proteomics analysis of FUS mutant human motoneurons reveals altered regulation of cytoskeleton and other ALS-linked proteins via 3′UTR binding
Garone, Maria Giovanna; Alfano, Vincenzo; Salvatori, Beatrice; Peruzzi, Giovanna; Colantoni, Alessio; Bozzoni, Irene; Rosa, Alessandro - 01a Articolo in rivista
paper: SCIENTIFIC REPORTS (London : Nature Publishing Group) pp. - - issn: 2045-2322 - wos: WOS:000550057200140 (10) - scopus: 2-s2.0-85087975715 (10)

11573/1441390 - 2020 - Identification of molecular signatures in neural differentiation and neurological diseases using digital color-coded molecular barcoding
Rosa, Alessandro - 01g Articolo di rassegna (Review)
paper: STEM CELLS INTERNATIONAL (SAGE-Hindawi) pp. - - issn: 1687-9678 - wos: WOS:000574291300001 (1) - scopus: 2-s2.0-85091699176 (1)

11573/1462047 - 2020 - High-throughput screening identifies histone deacetylase inhibitors that modulate GTF2I expression in 7q11.23 microduplication autism spectrum disorder patient-derived cortical neurons
Rosa, Alessandro - 01a Articolo in rivista
paper: MOLECULAR AUTISM (USA: BioMed Central Ltd) pp. - - issn: 2040-2392 - wos: WOS:000590512800001 (10) - scopus: 2-s2.0-85096225474 (11)

11573/1467643 - 2020 - The Aurora-A/TPX2 axis directs spindle orientation in adherent human cells by regulating NuMA and microtubule stability
Polverino, Federica; Naso, Francesco Davide; Rosa, Alessandro; Guarguaglini, Giulia - 01a Articolo in rivista
paper: CURRENT BIOLOGY (Current Biology Limited:84 Theobalds Road, London WC1X 8RR United Kingdom:011 44 20 76114202, EMAIL: info@biomednet.com, INTERNET: http://www.biomednet.com, Fax: 011 44 20 76114479) pp. - - issn: 0960-9822 - wos: WOS:000634648100012 (11) - scopus: 2-s2.0-85097762248 (11)

11573/1481384 - 2020 - HOTAIRM1 regulates neuronal differentiation by controlling NEUROGENIN 2 and the downstream neurogenic cascade
Rea, Jessica; Menci, Valentina; Tollis, Paolo; Santini, Tiziana; Tartaglia, Gian Gaetano; Rosa, Alessandro; Ballarino, Monica; Laneve, Pietro; Caffarelli, Elisa - 04f Poster
conference: 25th Annual Meeting of the RNA Society (Online)
book: 25th Annual Meeting of the RNA Society - ()

11573/1276468 - 2019 - Conversion of Human Induced Pluripotent Stem Cells (iPSCs) into Functional Spinal and Cranial Motor Neurons Using PiggyBac Vectors
Garone, Maria Giovanna; De Turris, Valeria; Brighi, Carlo; De Santis, Riccardo; Pagani, Francesca; Di Angelantonio, Silvia; Rosa, Alessandro - 01a Articolo in rivista
paper: JOURNAL OF VISUALIZED EXPERIMENTS ([Boston, Mass. : MYJoVE Corp., 2006]-) pp. - - issn: 1940-087X - wos: WOS:000469977600054 (9) - scopus: 2-s2.0-85066930236 (13)

11573/1297233 - 2019 - Mutant FUS and ELAVL4 (HuD) aberrant crosstalk in Amyotrophic Lateral Sclerosis
De Santis, Riccardo; Alfano, Vincenzo; De Turris, Valeria; Colantoni, Alessio; Garone, Maria Giovanna; Antonacci, Giovanni; Peruzzi, Giovanna; Aronica, Eleonora; Bozzoni, Irene; Rosa, Alessandro - 01a Articolo in rivista
paper: CELL REPORTS (Elsevier B.V. Cambridge MA: Cell Press) pp. 3818-3831 - issn: 2211-1247 - wos: WOS:000472715000011 (31) - scopus: 2-s2.0-85067263880 (33)

11573/1308383 - 2019 - Construction of 3D in vitro models by bioprinting human pluripotent stem cells: Challenges and opportunities
Salaris, Federico; Rosa, Alessandro - 01g Articolo di rassegna (Review)
paper: BRAIN RESEARCH (Elsevier BV:PO Box 211, 1000 AE Amsterdam Netherlands:011 31 20 4853757, 011 31 20 4853642, 011 31 20 4853641, EMAIL: nlinfo-f@elsevier.nl, INTERNET: http://www.elsevier.nl, Fax: 011 31 20 4853598) pp. - - issn: 0006-8993 - wos: WOS:000490627600023 (38) - scopus: 2-s2.0-85071118504 (44)

11573/1318360 - 2019 - 3D bioprinted human cortical neural constructs derived from induced pluripotent stem cells
Salaris, Federico; Brighi, Carlo; De Turris, Valeria; Benedetti, Maria Cristina; Ghirga, Silvia; Rosito, Maria; Di Angelantonio, Silvia; Rosa, Alessandro - 01a Articolo in rivista
paper: JOURNAL OF CLINICAL MEDICINE (MDPI Publishing, Basel, Switzerland) pp. - - issn: 2077-0383 - wos: WOS:000498398500093 (21) - scopus: 2-s2.0-85084064985 (22)

11573/1321703 - 2019 - Inducible SMARCAL1 knockdown in iPSC reveals a link between replication stress and altered expression of master differentiation genes
Pugliese, Giusj Monia; Salaris, Federico; Marabitti, Veronica; Rosa, Alessandro - 01a Articolo in rivista
paper: DISEASE MODELS & MECHANISMS (Cambridge : Company of Biologists, 2007-) pp. - - issn: 1754-8403 - wos: WOS:000494678100002 (8) - scopus: 2-s2.0-85073666516 (8)

11573/1344999 - 2019 - The long noncoding RNA HOTAIRM1 contributes to neuronal differentiation by regulating Neurogenin 2 expression
Rea, Jessica; Menci, Valentina; Santini, Tiziana; Rosa, Alessandro; Ballarino, Monica; Laneve, Pietro; Caffarelli, Elisa - 04f Poster
conference: IBPM Annual Meeting (National Research Council (CNR), Rome)
book: IBPM Annual Meeting - Abstracts - ()

11573/1345007 - 2019 - HOTAIRM1 regulates neuronal differentiation by controlling NEUROGENIN 2 and the downstream neurogenic cascade
Rea, Jessica; Menci, Valentina; Tollis, Paolo; Santini, Tiziana; Garone, Maria Giovanna; Cipriano, Andrea; Tartaglia, Gian Gaetano; Rosa, Alessandro; Ballarino, Monica; Laneve, Pietro; Caffarelli, Elisa - 04f Poster
conference: EMBO | EMBL Symposium: The Non-Coding Genome (EMBL Heidelberg, Germany)
book: EMBO | EMBL Symposium: The Non-Coding Genome - ABSTRACT BOOK - ()

11573/1356388 - 2019 - Influence of substrate stiffness on human induced pluripotent stem cells: Preliminary results
Rosa, Alessandro - 04b Atto di convegno in volume
conference: 41st Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBC 2019 (Berlin; Germany)
book: Proceedings of the Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBS - (978-1-5386-1311-5)

11573/1109389 - 2018 - Direct conversion of human pluripotent stem cells into cranial motor neurons using a piggyBac vector
De Santis, Riccardo; Garone, Maria Giovanna; Pagani, Francesca; De Turris, Valeria; Di Angelantonio, Silvia; Rosa, Alessandro - 01a Articolo in rivista
paper: STEM CELL RESEARCH (Amsterdam : Elsevier) pp. 189-196 - issn: 1873-5061 - wos: WOS:000434978900033 (20) - scopus: 2-s2.0-85046443648 (22)

11573/1163289 - 2018 - Background-deflection Brillouin microscopy reveals altered biomechanics of intracellular stress granules by ALS protein FUS
De Turris, Valeria; Rosa, Alessandro; Ruocco, Giancarlo - 01a Articolo in rivista
paper: COMMUNICATIONS BIOLOGY ([London]: Springer Nature) pp. 1-8 - issn: 2399-3642 - wos: WOS:000461126500139 (34) - scopus: 2-s2.0-85062398445 (37)

11573/1344947 - 2018 - Neurogenin 2 expression is regulated by the long noncoding RNA HOTAIRM1 during in vitro neuronal differentiation
Menci, Valentina; Santini, Tiziana; Rea, Jessica; Rosa, Alessandro; Laneve, Pietro; Caffarelli, Elisa - 04f Poster
conference: XV FISV CONGRESS (Sapienza University of Rome, Italy)
book: Program and Abstracts of the XV FISV CONGRESS - ()

11573/1010898 - 2017 - Importin-beta and CRM1 control a RANBP2 spatiotemporal switch essential for mitotic kinetochore function
Gilistro, Eugenia; De Turris, Valeria; Damizia, Michela; Verrico, Annalisa; Moroni, Sara; De Santis, Riccardo; Rosa, Alessandro - 01a Articolo in rivista
paper: JOURNAL OF CELL SCIENCE (The Company of Biologists Limited:Bidder Building, 140 Cowley Road, Cambridge CB4 0DL United Kingdom:011 44 1223 420482, EMAIL: mandy@thecob.demon.co.uk, INTERNET: http://www.biologists.com, Fax: 011 44 1223 423353) pp. 2564-2578 - issn: 0021-9533 - wos: WOS:000406770700013 (10) - scopus: 2-s2.0-85026638088 (9)

11573/1010900 - 2017 - FUS mutant human motoneurons display altered transcriptome and microRNA pathways with implications for ALS pathogenesis
De Santis, Riccardo; Santini, Laura; Colantoni, Alessio; Peruzzi, Giovanna; De Turris, Valeria; Alfano, Vincenzo; Bozzoni, Irene; Rosa, Alessandro - 01a Articolo in rivista
paper: STEM CELL REPORTS (Amsterdam : Elsevier) pp. ...-... - issn: 2213-6711 - wos: WOS:000415139400012 (56) - scopus: 2-s2.0-85030631001 (56)

11573/1011169 - 2017 - Role of microRNAs in zygotic genome activation: modulation of mRNA during embryogenesis
Rosa, Alessandro - 02a Capitolo o Articolo
book: Methods in Molecular Biology - (978-1-4939-6986-9; 978-1-4939-6988-3)

11573/1063175 - 2017 - Loss of miR-107, miR-181c and miR-29a-3p promote activation of Notch2 signaling in pediatric high-grade gliomas (pHGGs)
Catanzaro, Giuseppina; Sabato, Claudia; Russo, Michele; Rosa, Alessandro; Abballe, Luana; Besharat, Zein Mersini; Po, Agnese; Miele, Evelina; Bellavia, Diana; Chiacchiarini, Martina; Peruzzi, Giovanna; Napolitano, Maddalena; Antonelli, Manila; Giangaspero, Felice; Locatelli, Franco; Screpanti, Isabella; Vacca, Alessandra; Ferretti, Elisabetta - 01a Articolo in rivista
paper: INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (Basel: MDPI Center) pp. - - issn: 1422-0067 - wos: WOS:000418896700243 (15) - scopus: 2-s2.0-85038414048 (15)

11573/950933 - 2017 - FUS affects circular RNA expression in murine embryonic stem cell-derived motor neurons
Errichelli, Lorenzo; Dini Modigliani, Stefano; Laneve, Pietro; Colantoni, Alessio; Legnini, Ivano; Capauto, Davide; Rosa, Alessandro; De Santis, Riccardo; Peruzzi, Giovanna; Caffarelli, Elisa; Morlando, Mariangela; Bozzoni, Irene - 01a Articolo in rivista
paper: NATURE COMMUNICATIONS (London: Nature Publishing Group) pp. 14741- - issn: 2041-1723 - wos: WOS:000397796000001 (287) - scopus: 2-s2.0-85016645252 (295)

11573/845821 - 2016 - Long Noncoding RNA Regulation of Pluripotency
Rosa, Alessandro; Ballarino, Monica - 01a Articolo in rivista
paper: STEM CELLS INTERNATIONAL (SAGE-Hindawi) pp. 1-9 - issn: 1687-9678 - wos: WOS:000371082500001 (40) - scopus: 2-s2.0-84949949298 (49)

11573/867977 - 2016 - Mapping the amide I absorption in single bacteria and mammalian cells with resonant infrared nanospectroscopy
Baldassarre, Leonetta; Giliberti, Valeria; Rosa, Alessandro; Ortolani, Michele; Bonamore, Alessandra; Baiocco, Paola; Calvani, Paolo; Nucara, Alessandro - 01a Articolo in rivista
paper: NANOTECHNOLOGY (Bristol, United Kingdom: IOP Publishing Limited) pp. 075101- - issn: 0957-4484 - wos: WOS:000368935000006 (46) - scopus: 2-s2.0-84955465361 (45)

11573/877188 - 2016 - Differentiation of control and ALS mutant human iPSCs into functional skeletal muscle cells, a tool for the study of neuromuscolar diseases
Lenzi, Jessica; Pagani, Francesca; De Santis, Riccardo; Limatola, Cristina; Bozzoni, Irene; Di Angelantonio, Silvia; Rosa, Alessandro - 01a Articolo in rivista
paper: STEM CELL RESEARCH (Amsterdam : Elsevier) pp. 140-147 - issn: 1873-5061 - wos: WOS:000385278000026 (23) - scopus: 2-s2.0-84974720903 (25)

11573/892273 - 2016 - Divergent lncRNAs take the lead on pluripotent cell differentiation
Rosa, Alessandro; Ballarino, Monica - 01a Articolo in rivista
paper: STEM CELL INVESTIGATION (Hong Kong : AME Publishing Company) pp. 1-3 - issn: 2313-0792 - wos: (0) - scopus: 2-s2.0-84995407545 (1)

11573/892343 - 2016 - Protein clustering in chemically stressed HeLa cells studied by infrared nanospectroscopy
Giliberti, Valeria; Baldassarre, Leonetta; Rosa, Alessandro; De Turris, Valeria; Ortolani, Michele; Calvani, Paolo; Nucara, Alessandro - 01a Articolo in rivista
paper: NANOSCALE (Cambridge,UK: RCS PUBLISHING -Royal Society of Chemistry) pp. 17560-17567 - issn: 2040-3364 - wos: WOS:000386244400022 (14) - scopus: 2-s2.0-84991573866 (15)

11573/602782 - 2015 - N-terminus-modified Hec1 suppresses tumour growth by interfering with kinetochore-microtubule dynamics
Lenzi, Jessica; Rosa, Alessandro - 01a Articolo in rivista
paper: ONCOGENE (Macmillan Magazines Limited:Porters South Crinian Street, London N1 9XW United Kingdom:011 44 207 8334000, 011 44 171 8434982, Fax: 011 44 207 812358) pp. 3325-3335 - issn: 0950-9232 - wos: WOS:000356592300011 (8) - scopus: 2-s2.0-84931576420 (11)

11573/780455 - 2015 - Enriched environment reduces glioma growth through immune and non-immune mechanisms in mice
Garofalo, Stefano; D'alessandro, Giuseppina; Chece, Giuseppina; Maggi, Laura; Rosa, Alessandro; Porzia, Alessandra; Mainiero, Fabrizio; Esposito, Vincenzo; Lauro, Clotilde; Benigni, Giorgia; Bernardini, Giovanni; Santoni, Angela; Limatola, Cristina - 01a Articolo in rivista
paper: NATURE COMMUNICATIONS (London: Nature Publishing Group) pp. 6623-6636 - issn: 2041-1723 - wos: WOS:000353041300004 (90) - scopus: 2-s2.0-84926359060 (89)
book: Nature Communications - ()

11573/805324 - 2015 - ALS mutant FUS proteins are recruited into stress granules in induced pluripotent stem cells- derived motoneurons
Lenzi, Jessica; De Santis, Riccardo; Morlando, Mariangela; Laneve, Pietro; Rosa, Alessandro; Bozzoni, Irene - 01a Articolo in rivista
paper: DISEASE MODELS & MECHANISMS (Cambridge : Company of Biologists, 2007-) pp. 755-766 - issn: 1754-8403 - wos: WOS:000356495500012 (100) - scopus: 2-s2.0-84937876670 (104)

11573/832744 - 2015 - Pur-alpha functionally interacts with FUS carrying ALS-associated mutations
Piccinni, Violetta; Mantoni, Federico; Lenzi, Jessica; Rosa, Alessandro; Bozzoni, Irene; Cestra, Gianluca - 01a Articolo in rivista
paper: CELL DEATH & DISEASE (Nature Group) pp. 1-11 - issn: 2041-4889 - wos: WOS:000209870000013 (22) - scopus: 2-s2.0-84961132825 (22)

11573/559577 - 2014 - miR-373 is regulated by TGFβ signaling and promotes mesendoderm differentiation in human Embryonic Stem Cells
Rosa, Alessandro - 01a Articolo in rivista
paper: DEVELOPMENTAL BIOLOGY (Academic Press Incorporated:6277 Sea Harbor Drive:Orlando, FL 32887:(800)543-9534, (407)345-4100, EMAIL: ap@acad.com, INTERNET: http://www.idealibrary.com, Fax: (407)352-3445) pp. 81-88 - issn: 0012-1606 - wos: WOS:000336347000007 (33) - scopus: 2-s2.0-84899993384 (33)

11573/523318 - 2013 - Regulatory Non-Coding RNAs in Pluripotent Stem Cells
Rosa, Alessandro - 01a Articolo in rivista
paper: INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (Basel: MDPI Center) pp. 14346-14373 - issn: 1422-0067 - wos: WOS:000322171700084 (29) - scopus: 2-s2.0-84880087880 (33)

11573/526026 - 2013 - Non Coding RNA in Muscle Differentiation and Disease
Morlando, Mariangela; Rosa, Alessandro; Fatica, Alessandro; Bozzoni, Irene - 01a Articolo in rivista
paper: MICRORNA (Bentham Science Publishers) pp. 91-101 - issn: 2211-5374 - wos: (0) - scopus: 2-s2.0-85045248746 (0)

11573/506075 - 2012 - FUS stimulates microRNA biogenesis by facilitating co-transcriptional Drosha recruitment
Morlando, Mariangela; Dini Modigliani, Stefano; Torrelli, Giulia; Rosa, Alessandro; Di Carlo, Valerio; Caffarelli, Elisa; Bozzoni, Irene - 01a Articolo in rivista
paper: EMBO JOURNAL (attuale: NATURE PUBLISHING GROUP, 345 PARK AVENUE SOUTH, NEW YORK, USA, NY, 10010-1707 Precedente: Oxford University Press:Journals Department, Great Clarendon Street, Oxford OX2 6DP United Kingdom:011 44 1865 556767, EMAIL: jnlorders@oup.co.uk, INTERNET: http://www.oup.co.uk, Fax: 011 44 1865 267485) pp. 4502-4510 - issn: 0261-4189 - wos: WOS:000312446700004 (161) - scopus: 2-s2.0-84871002507 (172)

11573/436659 - 2011 - APOBEC2, a selective inhibitor of TGFβ signaling, regulates left-right axis specification during early embryogenesis.
Rosa, Alessandro - 01a Articolo in rivista
paper: DEVELOPMENTAL BIOLOGY (Academic Press Incorporated:6277 Sea Harbor Drive:Orlando, FL 32887:(800)543-9534, (407)345-4100, EMAIL: ap@acad.com, INTERNET: http://www.idealibrary.com, Fax: (407)352-3445) pp. 13-23 - issn: 0012-1606 - wos: WOS:000286547600002 (38) - scopus: 2-s2.0-78651227102 (36)

11573/436660 - 2011 - A regulatory circuitry comprised of miR-302 and the transcription factors OCT4 and NR2F2 regulates human embryonic stem cell differentiation
Rosa, Alessandro - 01a Articolo in rivista
paper: EMBO JOURNAL (attuale: NATURE PUBLISHING GROUP, 345 PARK AVENUE SOUTH, NEW YORK, USA, NY, 10010-1707 Precedente: Oxford University Press:Journals Department, Great Clarendon Street, Oxford OX2 6DP United Kingdom:011 44 1865 556767, EMAIL: jnlorders@oup.co.uk, INTERNET: http://www.oup.co.uk, Fax: 011 44 1865 267485) pp. 237-248 - issn: 0261-4189 - wos: WOS:000287179100003 (150) - scopus: 2-s2.0-78751640369 (166)

11573/436661 - 2010 - Synthetic mRNAs: Powerful tools for reprogramming and differentiation of human cells
Rosa, Alessandro - 01a Articolo in rivista
paper: CELL STEM CELL (Cambridge: Cell Press (an imprint of Elsevier)) pp. 549-550 - issn: 1934-5909 - wos: WOS:000284390500003 (16) - scopus: 2-s2.0-78049497848 (15)

11573/436662 - 2009 - microRNAs in early vertebrate development
Rosa, Alessandro - 01a Articolo in rivista
paper: CELL CYCLE (Landes Bioscience, c2002, Georgetown, TX) pp. 3513-3520 - issn: 1538-4101 - wos: WOS:000272218600022 (48) - scopus: 2-s2.0-70449707283 (50)

11573/436663 - 2009 - The miR-430/427/302 Family Controls Mesendodermal Fate Specification via Species-Specific Target Selection
Rosa, Alessandro - 01a Articolo in rivista
paper: DEVELOPMENTAL CELL (Cell Press:1100 Massachusetts Avenue:Cambridge, MA 02138:(617)661-7057, EMAIL: subs@cell.com, INTERNET: http://www.cellpress.com, Fax: (617)397-2850) pp. 517-527 - issn: 1534-5807 - wos: WOS:000265470400008 (178) - scopus: 2-s2.0-64549094131 (186)

11573/359942 - 2008 - Role of microRNAs in myeloid differentiation.
Fatica, Alessandro; Rosa, Alessandro; Ballarino, Monica; De Marchis, Maria Laura; Bozzoni, Irene - 01a Articolo in rivista
paper: BIOCHEMICAL SOCIETY TRANSACTIONS (Portland Press Limited:Commerce Way, Colchester CO2 8HP Essex United Kingdom:011 44 1206 796351, EMAIL: sales@portland-services.com, INTERNET: http://www.portland-services.com, Fax: 011 44 1206 799331) pp. 1201-1205 - issn: 0300-5127 - wos: WOS:000261749200021 (18) - scopus: 2-s2.0-59149089005 (17)

11573/234568 - 2007 - Emerging role for microRNAs in acute promyelocytic leukemia
Nervi, Clara; Fazi, Francesco; Rosa, Alessandro; Fatica, Alessandro; Bozzoni, Irene - 01a Articolo in rivista
paper: CURRENT TOPICS IN MICROBIOLOGY AND IMMUNOLOGY (Springer Verlag Germany:Tiergartenstrasse 17, D 69121 Heidelberg Germany:011 49 6221 3450, EMAIL: g.braun@springer.de, INTERNET: http://www.springer.de, Fax: 011 49 6221 345229) pp. 73-84 - issn: 0070-217X - wos: WOS:000244386500005 (19) - scopus: 2-s2.0-33847004435 (18)
book: Acute Promyelocytic Leukemia - (9783540345923)

11573/358943 - 2007 - Heterochromatic gene repression of the retinoic acid pathway in acute myeloid leukemia
Fazi, Francesco; Zardo, Giuseppe; Rosa, Alessandro; Bozzoni, Irene; Nervi, Clara - 01a Articolo in rivista
paper: BLOOD (American Society of Hematology:1900 M Street Northwest, Suite 200:Washington, DC 20036:(800)633-4931, (202)776-0544, EMAIL: publishing@hematology.org, ash@hematology.org, INTERNET: http://www.hematology.org, Fax: (202)776-0551) pp. 4432-4440 - issn: 0006-4971 - wos: WOS:000246609100053 (67) - scopus: 2-s2.0-34248356405 (78)

11573/41995 - 2007 - The interplay between the master transcription factor PU.1 and miR-424 regulates human monocyte/macrophage differentiation.
Ballarino, Monica; Guarini, Anna; Fatica, Alessandro; Bozzoni, Irene; Rosa, Alessandro; De Angelis, Fernanda Gabriella - 01a Articolo in rivista
paper: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (National Academy of Sciences:2101 Constitution Avenue Northwest:Washington, DC 20418:(877)314-2253, (615)377-3322, EMAIL: subspnas@nas.edu, INTERNET: http://www.pnas.org, Fax: (615)377-0525) pp. 19849-19854 - issn: 0027-8424 - wos: WOS:000251752200038 (230) - scopus: 2-s2.0-38049146022 (243)

11573/104037 - 2006 - Chimeric Adeno-Associated Virus/Antisense U1 Small Nuclear RNA Effectively Rescues Dystrophin Synthesis and Muscle Function by Local Treatment of mdx Mice.
Rosa, Alessandro; Sthandier, Olga Elena; De Angelis, Fernanda Gabriella; Nicoletti, Carmine; Musaro', Antonio; Bozzoni, Irene - 01a Articolo in rivista
paper: HUMAN GENE THERAPY (Mary Ann Liebert Incorporated:2 Madison Avenue:Larchmont, NY 10538:(914)834-3100, EMAIL: info@liebertpub.com, swilliams@liebertpub.com, INTERNET: http://www.liebertpub.com, Fax: (914)834-3688) pp. 565-574 - issn: 1043-0342 - wos: WOS:000237966300009 (38) - scopus: 2-s2.0-33646930313 (40)

11573/359930 - 2006 - MicroRNAs and Hematopoietic Differentiation
Fatica, Alessandro; Rosa, Alessandro; Fazi, Francesco; Ballarino, Monica; Morlando, Mariangela; Nervi, Clara; Bozzoni, Irene - 01a Articolo in rivista
paper: COLD SPRING HARBOR SYMPOSIA ON QUANTITATIVE BIOLOGY (Cold Spring Harbor Laboratory:500 Sunnyside Boulevard:Woodbury, NY 11797:(800)843-4388, (516)422-4100, EMAIL: cshpress@cshl.org, INTERNET: http://www.cshl.org, Fax: (516)422-4097) pp. 205-210 - issn: 0091-7451 - wos: WOS:000245962800027 (14) - scopus: 2-s2.0-34250654985 (15)

11573/364616 - 2006 - Body-wide gene therapy of Duchenne muscular dystrophy in the mdx mouse model
Denti, Michela Alessandra; Rosa, Alessandro; Sthandier, Olga Elena; De Angelis, Fernanda Gabriella; Nicoletti, Carmine; Musaro', Antonio; Bozzoni, Irene - 01a Articolo in rivista
paper: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (National Academy of Sciences:2101 Constitution Avenue Northwest:Washington, DC 20418:(877)314-2253, (615)377-3322, EMAIL: subspnas@nas.edu, INTERNET: http://www.pnas.org, Fax: (615)377-0525) pp. 3758-3763 - issn: 0027-8424 - wos: WOS:000236225300047 (110) - scopus: 2-s2.0-33644857020 (116)

11573/465550 - 2006 - AML1/ETO causes heterochromatic gene silencing of the retinoic acid signaling pathway in Acute Myeloid Leukemia
Fazi, Francesco; Zardo, Giuseppe; Rosa, Alessandro; Bozzoni, Irene; Nervi, Clara - 04c Atto di convegno in rivista
paper: HAEMATOLOGICA (Fondaz Ferrata Storti:Strada Nuova 134, 27100 Pavia Italy:011 39 0382 531182, EMAIL: office@haematologica.it, Fax: 011 39 0382 27721) pp. 40-40 - issn: 0390-6078 - wos: (0) - scopus: 2-s2.0-32544444885 (27)
conference: IX Congress of the Italian Society of Experimental Hematology (Naples, Italy)

11573/363106 - 2005 - A minicircuitry comprised of microRNA-223 and transcription factors NFI-A and C/EBPalpha regulates human granulopoiesis.
Fazi, Francesco; Rosa, Alessandro; Fatica, Alessandro; De Marchis, Maria Laura; Nervi, Clara; Bozzoni, Irene - 01a Articolo in rivista
paper: CELL (Cell Press:1100 Massachusetts Avenue:Cambridge, MA 02138:(617)661-7057, EMAIL: subs@cell.com, INTERNET: http://www.cellpress.com, Fax: (617)397-2850) pp. 819-831 - issn: 0092-8674 - wos: WOS:000233814100016 (796) - scopus: 2-s2.0-28344438648 (861)

11573/363082 - 2004 - A new vector, based on the PolII promoter of the U1 snRNA gene, for the expression of siRNAs in mammalian cells
Denti, Michela Alessandra; Rosa, Alessandro; Sthandier, Olga Elena; De Angelis, Fernanda Gabriella; Bozzoni, Irene - 01a Articolo in rivista
paper: MOLECULAR THERAPY (Academic Press Incorporated:6277 Sea Harbor Drive:Orlando, FL 32887:(800)543-9534, (407)345-4100, EMAIL: ap@acad.com, INTERNET: http://www.idealibrary.com, Fax: (407)352-3445) pp. 191-199 - issn: 1525-0016 - wos: WOS:000223106100024 (65) - scopus: 2-s2.0-3042854926 (69)

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