ALESSANDRO GIUFFRE'



email: alessandro.giuffre@uniroma1.it
telefono: 06499109761
edificio: CU027
stanza: T9

A) PERSONAL DETAILS

Alessandro Giuffrè
Director, Institute of Molecular Biology and Pathology, National Research Council of Italy (CNR-IBPM)
P.le Aldo Moro 5, 00185 Rome, Italy
Webpage: https://www.ibpm.cnr.it/go/alessandro-giuffre

Author identifiers

  • ORCID iD: 0000-0001-5301-0681

  • Scopus Author ID: 7003270357

  • Web of Science ResearcherID: K-4341-2015

  • Loop: 184580

  • ResearchGate: Alessandro_Giuffre

  • Google Scholar: yuiCJh8AAAAJ

B) EDUCATION

  • 1993 – University Degree (cum laude) in Biology, Sapienza University of Rome (Italy)

  • 1997 – Ph.D. in Biochemistry, Sapienza University of Rome (Italy)

C) APPOINTMENTS AT RESEARCH INSTITUTIONS

  • Apr 2020 – present – Director, CNR-IBPM, Rome (Italy)

  • Feb 2020 – Apr 2020 – Science Manager, CNR-IBPM, Rome (Italy)

  • Jul 2001 – Feb 2020 – Senior Research Fellow, CNR-IBPM, Rome (Italy)

  • Dec 1998 – Jul 2001 – Research Fellow, CNR Center of Molecular Biology, Rome (Italy)

  • 1997 – 1998 – Postdoctoral Fellow, Accademia Nazionale dei Lincei, Rome (Italy)

D) MAIN RESEARCH INTERESTS

  1. Hydrogen sulfide metabolism: biochemistry and impact on health and disease

  2. Gasotransmitters and cellular bioenergetics

  3. Energy metabolism and antioxidant defence in microorganisms: identification of drug targets

E) RESEARCH ACTIVITY ABROAD

Research periods in the following laboratories:

  • University of Lisbon / ITQB, Oeiras (Portugal) – Lab: Prof. M. Teixeira; Dr. J.B. Vicente
    7–17 May 1997; 29 Sep–7 Oct 2002; 20–27 Jul 2003; 10–17 Apr 2005; 2–9 Jul 2005; 12–19 Feb 2006; 9–22 Sep 2007; 6–19 Jul 2008; 23 Nov–3 Dec 2011; 12–19 Jul 2012; 18–29 Nov 2012; 23 Jun–2 Jul 2013; 1–9 Nov 2013; 20–29 Oct 2014; 7–13 Jun 2015; 1–8 Nov 2015; 14–21 Jun 2016; 2–7 Dec 2016; 13–20 Oct 2019

  • University of Helsinki (Finland) – Lab: Prof. M. Wikström, Institute of Biotechnology (25 Nov–4 Dec 2002)

  • University of Frankfurt (Germany) – Lab: Prof. B. Ludwig, Institute of Biochemistry (5–23 Jul 1999; 9–22 Jul 2000)

  • University of East Anglia (UK) – Lab: Prof. C. Greenwood, School of Biological Sciences (23–28 Jun 1996)

  • NIH, Bethesda, MD (USA) – Lab: Prof. E. Henry, Dept. of Health and Human Services (28 Jun–7 Jul 1995; 12–22 Feb 1996)

  • University of Groningen (Netherlands) – Lab: Prof. W.N. Konings, Dept. of Microbiology (5–10 Dec 1994)

  • Medical University of Lübeck (Germany) – Lab: Prof. G. Schaefer, Institute of Biochemistry (10–23 Oct 1993; 4–11 Mar 1995)

  • University of Essex, Colchester (UK) – Lab: Prof. M.T. Wilson, Dept. of Chemistry and Biological Chemistry (24–30 Jun 1991; 11–16 Sep 1994)

  • EMBL, Heidelberg (Germany) – Lab: Dr. M. Saraste (18 Nov–14 Dec 1991)

F) MAIN ONGOING INTERNATIONAL COLLABORATIONS

  • João Vicente, Miguel Teixeira, Ligia Saraiva – University of Lisbon (Portugal)

H) METRICS

  • Scopus: Publications 98; Citations 4,343; H-index 38

  • Web of Science: Publications 100; Citations 4,004; H-index 37

  • Google Scholar: Publications 132; Citations 5,637; H-index 44

I) ACADEMIC APPOINTMENTS

  • Since 2005 – Visiting Professor, ITQB, New University of Lisbon (Portugal)

  • Since 2012 – Teaching Board Member, Ph.D. in Biochemistry, Sapienza University of Rome (Italy)

  • 2018 – 2021 – Lecturer in charge, Pharmacy Degree Course, Sapienza University of Rome (Italy)

  • Since 2014 – National Scientific Qualification (ASN) to Full Professor (SSD E1/05 – Biochemistry)

  • Since 2007 – Evaluator in Ph.D. thesis defences or mid-term exams (8 sessions): Stockholm (Sweden), Lisbon (Portugal), Aarhus (Denmark), Amsterdam (Netherlands)

  • 2000 – 2017 – Lecturer in charge, Course of Biomedical Laboratory Techniques, Sapienza University of Rome (Italy)

L) FUNDED PROJECTS (SELECTED)

  • PRIN (MUR – 20224BYR59) – Hydrogen sulfide metabolism in Pseudomonas aeruginosa (patho)physiology (28/09/2023 – 27/09/2025)

  • PRIN (MIUR – 20158EB2CM_003) – Hydrogen sulphide as a new player of Amyotrophic Lateral Sclerosis: focus on mitochondrial homeostasis (05/02/2017 – 04/02/2020)

  • PNR-CNR Ageing Project (MIUR) – Role of redox mechanisms and protein accumulation in age-related diseases (2012 – 2018)

  • Bilateral CNR–FCT (Portugal) – Hydrogen sulfide metabolism in colon-cancer (2015 – 2016)

  • Bilateral CNR–FCT (Portugal) – Interaction between gasotransmitters (H2S, NO and CO) and metalloproteins: physiological relevance (2013 – 2014)

  • FIRB (Futuro in Ricerca 2008, MIUR – RBFR08F41U) – Novel mechanisms of the microbial stress response to oxidative and nitrosative stress (Dec 2010 – Nov 2013)

  • Bilateral CNR–FCT (Portugal) – Response to oxidative stress in Giardia intestinalis and Entamoeba histolytica (2011 – 2012)

  • ESCMID Research Grant (2009) – Response of Giardia intestinalis to oxidative and nitrosative stress (Mar 2009 – Feb 2011)

  • Bilateral CNR–GRICES (Portugal) – Nitric oxide detoxification in pathogenic microorganisms: structure-function relationships in flavodiiron proteins (2005 – 2008)

  • CNR project (commessa a tema libero) – Mechanisms of nitric oxide detoxification in pathogenic microorganisms: role of flavodiiron proteins (2005)

  • MIUR (Giovani Ricercatori – 2002) – Cytochrome c oxidase: role of proton transfer pathways in intramolecular electron transfer (Oct 2002 – Oct 2003)

M) MANAGEMENT

  • Apr 2020 – present – Director, CNR Institute of Molecular Biology and Pathology

  • Feb 2010 – 2015 – Scientific Director, CNR project “Structure, function and design of proteins, nucleic acids and supramolecular complexes” (CNR Dept. of Life Sciences)

  • 2005 – 2009; 2014 – 2018 – Executive Board Member, Italian Group of Bioenergetics and Biomembranes (GIBB)

Co-organizer (selected initiatives)

  • Redox Webinar Series (2022 – present)

  • International Workshop on Biochemistry, Physiology and Pharmacology of Oxidative Stress – Rome (2–4 Jul 2015)

  • 38th GIBB Annual Meeting – Rome (24–27 May 2011)

  • 32nd GIBB Annual Meeting – Rome (13–15 Jun 2005)

  • 29th GIBB Annual Meeting – Rome (2–4 May 2002)

  • International meeting “Structure and Function of Terminal Oxidases” – Rome/Rieti (May 1994)

N) REVIEW AND EDITORIAL WORK

Reviewer of grant proposals / academic positions (selected institutions)

  • MIUR – FIRB/SIR/Giovani Montalcini/VQR 2011–2014 (since 2013)

  • NSERC (Canada) (2023)

  • MRC (UK) (2014, 2022)

  • Swiss National Foundation (Switzerland) (2019, 2021, 2022)

  • BBSRC (UK) (2020)

  • National Science Foundation (USA) (2019)

  • NWO (Netherlands) (2010)

  • Trent University (Canada) (2017)

  • University of Padova (Italy) (2016)

  • University of Bordeaux (France) (2015)

Editorial roles

  • PLOS ONE Academic Editor (2013 – 2022)

  • Guest Editor, Antioxidants (2020 – 2021)

Reviewer for journals (selected)
Nature Communications; Nature Chemical Biology; Science Advances; Journal of Biological Chemistry; Biochemistry; Antioxidants & Redox Signaling; Redox Biology; Free Radical Biology & Medicine; Scientific Reports; PLoS Pathogens; BBA–Bioenergetics; FEBS Letters; Molecular Microbiology; Antimicrobial Agents and Chemotherapy; Journal of Bacteriology; International Journal of Molecular Sciences; Journal of Biological Inorganic Chemistry; Nitric Oxide; Trends in Parasitology; and others.

O) AWARDS AND HONORS

  • Since 2005 – Visiting Professor, ITQB, New University of Lisbon (Portugal)

  • Since 2015 – Academician, Medical Academy of Medicine of Rome

  • 2014 – 2018 – Vice-President, Italian Group of Bioenergetics and Biomembranes (GIBB)

  • 2004 – Maria Teresa Tessori Roncaglia e Eugenio Mari Award, Accademia Nazionale dei Lincei

  • 2002 – McGraw-Hill Award, Italian Society of Biochemistry and Molecular Biology

  • 1997 – 1998 – Fellowship in Biophysics, Centro Interdisciplinare Linceo – Accademia Nazionale dei Lincei

  • 1997 – Ph.D. Thesis Award, Fondazione Cenci Bolognetti

  • 1991 – Luca Barone Award, Accademia Nazionale dei Lincei

P) SPEAKER AT INTERNATIONAL MEETINGS (SELECTED)

  • 2018 – Bacterial Electron Transfer Processes and their Regulation, Saint Tropez (France)

  • 2016 – XIX International Conference on Oxygen Binding and Sensing Proteins, Hamburg (Germany)

  • 2016 – XIV Congress of the Italian Federation of Life Sciences, Rome (Italy)

  • 2016 – 19th European Bioenergetics Conference, Riva del Garda (Italy)

  • 2016 – 4th International Conference on the Biology of Hydrogen Sulfide, Naples (Italy)

  • 2015 – Bacterial Electron Transfer Processes and their Regulation, Vimeiro (Portugal)

  • 2015 – Closing Action Conference, European Network on Gasotransmitters, Athens (Greece)

  • 2014 – 13th International Conference of Parasitology, Mexico City (Mexico)

  • 2014 – 18th European Bioenergetics Conference, Lisbon (Portugal)

  • 2014 – 18th International Conference on Oxygen-Binding and Sensing Proteins, Sheffield (UK)

  • 2012 – Satellite Symposium on Microbes and NO (NO Conference), Edinburgh (UK)

  • 2012 – IV International Giardia and Cryptosporidium Conference, Wellington (New Zealand)

  • 2011 – 9th Indo-Italian Workshop on Chemistry and Biology of Antioxidants, New Delhi (India)

  • 2008 – Annual Molecular Parasitology Meeting, Woods Hole (USA)

  • 2007 – Summer School on Mitochondrial Respiratory Physiology, Schröcken (Austria)

  • 2006 – Young Researchers Forum, European Biological Inorganic Chemistry, Aveiro (Portugal)

  • 2005 – International Conference on Mitochondria, Bari (Italy)

  • 2004 – European Bioenergetics Conference, Pisa (Italy)

  • 2002 – Course of the Portuguese Biophysical Society, Santarém (Portugal)

  • 2000 – Villa Vigoni Conference, Loveno di Menaggio (Italy)

  • 2000 – Sigrid Juselius International Symposium, Helsinki (Finland)


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