Phd in LIFE SCIENCE

Title of research project: ANGPTL3 deficiency-induced hypolipidemia triggers spontaneous IFN response

Thematic area: Immunology and immunometabolism

SSD: MED46

RESEARCH EXPERIENCE:
- from February 2021 to October 2021: attendance at the Department of Internal Medicine, Anesthesiology and Cardiovascular Sciences in the immunoregulation laboratory.
“Sapienza” Università di Roma (Italy).
Type of business: research

FELLOWSHIP
- from March 2019 to January 2021: Research fellowship of Pasteur Institute at the Department of Internal Medicine, Anesthesiology and Cardiovascular Sciences in the immunoregulation laboratory to develop the master's degree project.
“Sapienza” Università di Roma (Italy)
Type of business: research

EDUCATION AND TRAINING:
- from November 2021: PhD school in Lifesciences XXXVII cycle, “Sapienza” Università di Roma (Italy).

- from November 2019 to January 2021: Master Degree in Medical Biotechnologies (Biomolecular Curriculum), “Sapienza” Università di Roma (Italy).
Title of thesis: <>
Director of studies: Prof.ssa Silvia Piconese
110/110 cum laude

- from November 2015 to October 2018: Bachelor's degree in Biotechnologies
Title of the thesis: <>
Università degli Studi della Tuscia, Viterbo.
Director of studies: Prof. Davide Cervia
110/110 cum laude

- from 2009 to 2014: Scientific High School Diploma
Liceo scientifico Carlo Jucci, Rieti.

COURSES:
- November 2021, State Exam: Biologists register
Eligible
- November 2017, CEFR B2 Advance Language Proficiency, British Institutes

Formal participation to funded research projects
T-OXIC
Title: T cell-intrinsic roles of BRCA1 in the oxidative stress resistance
of effector and regulatory CD4 T cells in triple negative breast cancer
Years: 5
funding agency: AIRC
PI: Silvia Piconese
Granted amount: 540.000

Progetto di Ateneo
Title: Metabolic control of monocyte activation in the severe hypolipidemia caused by ANGPTL3 genetic deficiency
Years: 1
Funding agency: Sapienza
PI: Silvia Piconese
Granted amount: 4000

Progetti per Avvio alla Ricerca - Tipo 1
Title: ANGPTL3 deficiency-induced hypolipidemia triggers spontaneous IFN response through ER stress
Years: 1
Funding agency: Sapienza
PI: Alessandra Pinzon Grimaldos
Granted amount: 1308

Seminars, meetings, courses
CONGRESSES
XIII SIICA NATIONAL CONGRESS 2022, Naples, as poster presenter
SIICA PhD retreat 2022, Aquila, as speaker
XIV SIICA NATIONAL CONGRESS 2023, Verona, as poster presenter
CICON 2023, Milano, as poster presenter
COURSES
SIICA Virtual School of Immunology 2022
Sperimentazione Preclinica e Benessere Animale dell'Università di Roma La Sapienza, 2023
SIICA Virtual School of Immunology 2023
SEMINARS
SYMPOSIUM SIICA-SYIS 2023, Rome.

RESEARCH PRODUCTS

• 11573/1605234 - 2021 - The role of lipid metabolism in shaping the expansion and the function of regulatory T cells.
Alessandra Pinzon Grimaldos, Simone Bini, Ilenia Pacella, Alessandra Rossi, Alessia Di Costanzo, Ilenia Minicocci, Laura D'erasmo, Marcello Arca, Silvia Piconese.

• 11573/1659888 - 2022 - ANGPTL3 deficiency associates with the expansion of regulatory T cells with reduced lipid content.
Alessandra Pinzon Grimaldos, Ilenia Pacella, Simone Bini, Gloria Tucci, Ilenia Cammarata, Alessia Di Costanzo, Ilenia Minicocci, Laura D'erasmo, Marcello Arca, Silvia Piconese.

• 11573/1659889 - 2022 - Baricitinib therapy response in rheumatoid arthritis patients associates to STAT1 phosphorylation in monocytes.
Gloria Tucci, Cristina Garufi, Ilenia Pacella, Alessandra Pinzon Grimaldos, Fulvia Ceccarelli, Fabrizio Conti, Francesca Romana Spinelli, Silvia Piconese.

• 2023 - Reduction in regulatory T cells in preterm newborns is associated with necrotizing enterocolitis: observational pilot study.
Ilenia Pacella, Maria Di Chiara, Rita Prota, Chiara De Luca, Annalisa Cardillo, Elena Potenza, Alessandra Pinzon Grimaldos, Valeria Pinna, Silvia Piconese AND Gianluca Terrin.