ALAIN JONATHAN GELIBTER

Dottore di ricerca

ciclo: XXXIII



Titolo della tesi: Studio pilota sull’identificazione di biomarcatori circolanti nel tumore del rene metastatico in trattamento di I linea con Pazopanib e Sunitinib

Con l’introduzione nella pratica clinica degli inibitori di tirosin-kinasi verso il recettore di VEGF (VEGFR–TKIs) prima, e degli immune-checkpoint inhibitor (ICIs) dopo, la prognosi e la sopravvivenza dei pazienti affetti da carcinoma del rene metastatico è radicalmente cambiata. Però, non tutti i pazienti beneficiano dei trattamenti, e qualche paziente risponde in maniera migliore ad una piuttosto che ad un’altra terapia. Ad oggi non abbiamo in mano biomarcatori validati che possano aiutarci nella scelta del miglior trattamento per il singolo paziente. Perciò la ricerca di biomarcatori affidabili, e con essi la comprensione di alcuni meccanismi molecolari che sottendono alla risposta, nonché la modulazione immunitaria, sono fortemente ricercati. Sappiamo infatti che l’outcome clinico di questi pazienti è molte volte collegato alla risposta immunitaria verso l’host. In questo studio pilota abbiamo indagato la modulazione immunitaria susseguente al trattamento di I linea con TKIs (Pazopanib e Sunitinib) per rintracciare e definire una serie di biomarker circolanti che potessero agire da eventuali fattori predittivi, ed aiutarci nella scelta del miglior trattamento disponibile Nello studio, prospettico, osservazionale, multicentrico sono stati arruolati pazienti affetti da carcinoma renale metastatico avviati a trattamento con TKI di I linea. In tutti i pazienti sono stati valutati i livelli circolanti delle cellule T exhausted/attivate/regolatorie, attraverso citometria a flusso di 14 proteine connesse agli immunocheckpoint, e di 20 citochine e chemochine infiammatorie, usando il multiplex Luminex assay, al baseline e durante il trattamento con TKIs. Abbiamo identificato le seguenti sottopopolazioni a cellule T CD3+CD8+CD137+ e CD3+CD137+PD1+ così come 7 molecole immunosolubili circolanti (iIFNγ, sPDL2, sHVEM, sPD1, sGITR, sPDL1, and sCTLA4) che correlavano con l’outcome clinico ed in alcuni casi venivano modulate dal trattamento con TKI. Questi risultati suggeriscono una importante caratterizzazione del profilo immunologico dei pazienti con carcinoma del rene metastatico. Tali dati, riportati nella tabella, potrebbero aiutarci nell’algoritmo decisionale della migliore scelta terapeutica, della migliore associazione o sequenza di farmaci, anche nell’ottica dell’imminente approvazione di terapie di combinazione (TKI + ICI) (ICI+ ICI) in prima linea.

Produzione scientifica

  • 11573/1684934 - 2023 - Circulating natural killer cells as prognostic value for non-small-cell lung cancer patients treated with Immune checkpoint inhibitors: correlation with sarcopenia (01a Articolo in rivista)
    TENUTA, MARTA; PANDOZZI, CARLA; SCIARRA, FRANCESCA; CAMPOLO, FEDERICA; SIRGIOVANNI, GRAZIA; CORTESI, ENRICO; LENZI, ANDREA; ISIDORI, ANDREA; SBARDELLA, EMILIA; VENNERI, MARY ANNA
  • 11573/1100735 - 2018 - TK inhibitor pazopanib primes DCs by downregulation of the β-catenin pathway (01a Articolo in rivista)
    ZIZZARI, ILARIA GRAZIA; NAPOLETANO, CHIARA; BOTTICELLI, ANDREA; CAPONNETTO, SALVATORE; CALABRO', FABIO; RUGHETTI, AURELIA; RUSCITO, ILARY; RAHIMI KOSHKAKI, HASSAN; MARCHETTI, PAOLO; NUTI, MARIANNA
  • 11573/1692559 - 2023 - Circulating CD137+T cells as an immune biomarker for response to anti-PD1 immunotherapy in NSCLC patients (04f Poster)
    ASQUINO, ANGELA; SCIROCCHI, FABIO; PACE, ANGELICA; ZIZZARI, ILARIA GRAZIA; SIRINGO, MARCO; TRAMONTANO, ELISA; CORTESI, ENRICO; NUTI, MARIANNA; RUGHETTI, AURELIA; NAPOLETANO, CHIARA
  • 11573/1676308 - 2022 - Safety and efficacy of combining afatinib and whole-brain radiation therapy in treating brain metastases from EGFR-mutated NSCLC: a case report and literature review (01i Case report)
    MARAMPON, FRANCESCO; CICCO, PIER RODOLFO; PARISI, MARTINA; SERPONE, MARIA; DE FELICE, FRANCESCA; CORTESI, ENRICO; TOMBOLINI, VINCENZO
  • 11573/1121575 - 2018 - Italian Nivolumab Expanded Access Program in Nonsquamous Non-Small Cell Lung Cancer Patients: Results in Never-Smokers and EGFR-Mutant Patients (01a Articolo in rivista)
    QUADRINI, SILVIA; LO RUSSO, GIUSEPPE
  • 11573/1678079 - 2022 - Non-small-cell lung cancer: how to manage ALK-, ROS1- and NTRK-rearranged disease (01a Articolo in rivista)
    MARINELLI, DANIELE; SIRINGO, MARCO
  • 11573/1691666 - 2023 - Surgical and survival outcomes with perioperative or neoadjuvant immune-checkpoint inhibitors combined with platinum-based chemotherapy in resectable NSCLC: A systematic review and meta-analysis of randomised clinical trials (01g Articolo di rassegna (Review))
    MARINELLI, DANIELE; GALLINA, FILIPPO TOMMASO; DI CIVITA, MATTIA ALBERTO; TORCHIA, ANDREA; GIUSTI, RAFFAELE; ROBERTO, MICHELA; VERRICO, MONICA; OCCHIPINTI, MARIO; BOTTICELLI, ANDREA; CORTESI, ENRICO; SANTINI, DANIELE
  • 11573/1121624 - 2017 - Use of adjuvant chemotherapy after surgery in patients with colon cancer (01a Articolo in rivista)
    MOSILLO, CLAUDIA; SIRGIOVANNI, GRAZIA
  • 11573/1681943 - 2021 - Predictive ability of a drug-based score in patients with advanced non-small-cell lung cancer receiving first-line immunotherapy (01a Articolo in rivista)
    FILETTI, MARCO; SIRINGO, MARCO
  • 11573/1136984 - 2018 - Coexistence of three EGFR mutations in an NSCLC patient: A brief report (01a Articolo in rivista)
    BELARDINILLI, FRANCESCA; GRADILONE, ANGELA; ZANI, MASSIMO; OCCHIPINTI, MARIO; FERRARO, SERGIO; NICOLAZZO, CHIARA; COPPA, ANNA; GIANNINI, GIUSEPPE
  • 11573/1684569 - 2023 - Evaluation of efficacy of ALK inhibitors according to body mass index in ALK rearranged NSCLC patients—A retrospective observational study (01a Articolo in rivista)
    SIRINGO, MARCO; GENTILE, GABRIELLA; CAPONNETTO, SALVATORE; SANTINI, DANIELE; CORTESI, ENRICO
  • 11573/1187945 - 2019 - A multicenter REtrospective observational study of first-line treatment with PERtuzumab, trastuzumab and taxanes for advanced HER2 positive breast cancer patients. RePer Study (01a Articolo in rivista)
    PIZZUTI, LAURA; MENTUCCIA, LUCIA; SPERDUTI, ISABELLA; BARBA, MADDALENA; BARCHIESI, GIACOMO; MAGRI, VALENTINA; BOTTICELLI, ANDREA; FABBRI, MARIA AGNESE; MAZZOTTA, MARCO; SANTINI, DANIELE; MARCHETTI, PAOLO; TOMAO, SILVERIO
  • 11573/1484793 - 2020 - Clinicopathologic correlates of first-line pembrolizumab effectiveness in patients with advanced NSCLC and a PD-L1 expression of ≥ 50% (01a Articolo in rivista)
    GIUSTI, RAFFAELE; MARCHETTI, PAOLO; FILETTI, MARCO
  • 11573/1676730 - 2022 - Systemic effect of radiotherapy before or after nivolumab in lung cancer: an observational, retrospective, multicenter study (01a Articolo in rivista)
    MARCHETTI, PAOLO; COGNETTI, FRANCESCO; CORTESI, ENRICO
  • 11573/1058654 - 2017 - PD-L1 and epithelial-mesenchymal transition in circulating tumor cells from non-small cell lung cancer patients: a molecular shield to evade immune system? (01a Articolo in rivista)
    RAIMONDI, CRISTINA; CARPINO, GUIDO; NICOLAZZO, CHIARA; GRADILONE, ANGELA; GIANNI, WALTER; GAUDIO, EUGENIO; CORTESI, ENRICO; GAZZANIGA, PAOLA
  • 11573/1311279 - 2009 - Capecitabine and celecoxib as second-line treatment of advanced pancreatic and biliary tract cancers (01a Articolo in rivista)
    MILELLA, MICHELE STANISLAW; SPERDUTI, ISABELLA; COGNETTI, FRANCESCO
  • 11573/1310446 - 2012 - EGFR molecular profiling in advanced NSCLC: a prospective phase II study in molecularly/clinically selected patients pretreated with chemotherapy (01a Articolo in rivista)
    MILELLA, MICHELE STANISLAW; SPERDUTI, ISABELLA; CUPPONE, FRANCESCA; D'ALICANDRO, VALERIO; FELICIONI, LORENZO; COGNETTI, FRANCESCO
  • 11573/1310499 - 2011 - Outcome of advanced NSCLC patients harboring sensitizing EGFR mutations randomized to EGFR tyrosine kinase inhibitors or chemotherapy as first-line treatment. A meta-analysis (01a Articolo in rivista)
    MILELLA, MICHELE STANISLAW; CUPPONE, FRANCESCA; NOVELLO, SEBASTIANO; SPERDUTI, ISABELLA; COGNETTI, FRANCESCO
  • 11573/1311175 - 2009 - Clinical implications of KRAS mutations in lung cancer patients treated with tyrosine kinase inhibitors. an important role for mutations in minor clones (01a Articolo in rivista)
    MARCHETTI, ANTONIO; MILELLA, MICHELE STANISLAW; COGNETTI, FRANCESCO
  • 11573/1684570 - 2023 - Type 2 diabetes mellitus and efficacy outcomes from imune checkpoint blockade in patients with cancer (01a Articolo in rivista)
    SANTINI, DANIELE; GIUSTI, RAFFAELE; FILETTI, MARCO; LO BIANCO, FRANCESCA; MARCHETTI, PAOLO; BOTTICELLI, ANDREA; SIRINGO, MARCO; MACRINI, SERENA; ZORATTO, FEDERICA
  • 11573/1310468 - 2011 - Emerging pathways and future targets for the molecular therapy of pancreatic cancer (01a Articolo in rivista)
    CUPPONE, FRANCESCA; CIUFFREDA, LAURA; COGNETTI, FRANCESCO; MILELLA, MICHELE STANISLAW
  • 11573/1310610 - 2010 - Fixed-dose-rate gemcitabine. A viable first-line treatment option for advanced pancreatic and biliary tract cancer (01a Articolo in rivista)
    MILELLA, MICHELE STANISLAW; SPERDUTI, ISABELLA; COGNETTI, FRANCESCO
  • 11573/1309719 - 2013 - First-line erlotinib and fixed dose-rate gemcitabine for advanced pancreatic cancer (01a Articolo in rivista)
    SPERDUTI, ISABELLA; COGNETTI, FRANCESCO; MILELLA, MICHELE STANISLAW
  • 11573/1347637 - 2020 - Immune checkpoint inhibitor-induced inflammatory arthritis persists after immunotherapy cessation by Braaten et al: another point of view (01b Commento, Erratum, Replica e simili)
    CECCARELLI, FULVIA; BOTTICELLI, ANDREA; LECCESE, ILARIA; LUCCHETTI, RAMONA; CORTESI, ENRICO; VALESINI, GUIDO; MARCHETTI, PAOLO; CONTI, FABRIZIO
  • 11573/1350495 - 2018 - Effect of bone metastases on immunotherapy efficacy in pretreated advanced non small cell lung cancer (NSCLC). (04d Abstract in atti di convegno)
    STATI, VALERIA
  • 11573/1347624 - 2019 - Women with synchronous or metachronous lung and ovarian cancer: A multi-institutional report (01a Articolo in rivista)
  • 11573/1348311 - 2007 - Sequential chemotherapy in nonsmall-cell lung cancer: Cisplatin and gemcitabine followed by docetaxel (01a Articolo in rivista)
  • 11573/1348296 - 2008 - Bevacizumab: One treatment for all the seasons? [5] (01b Commento, Erratum, Replica e simili)
    COGNETTI, FRANCESCO
  • 11573/1348285 - 2013 - Changing monoclonal antibody keeping unaltered the chemotherapy regimen in metastatic colorectal cancer patients: Is efficacy maintained? (01a Articolo in rivista)
  • 11573/1348307 - 2007 - Old age: Biologic versus chronologic [15] (01b Commento, Erratum, Replica e simili)
    COGNETTI, FRANCESCO
  • 11573/1348305 - 2007 - Gemcitabine-based combinations for inoperable pancreatic cancer: Have we made real progress? A meta-analysis of 20 phase 3 trials (01a Articolo in rivista)
    COGNETTI, FRANCESCO
  • 11573/1348313 - 2006 - Are dose-finding studies still necessary when targeted therapy is associated with chemotherapy? [5] (01b Commento, Erratum, Replica e simili)
    COGNETTI, FRANCESCO
  • 11573/750621 - 2013 - Advances towards the design and development of personalized non-small-cell lung cancer drug therapy (01a Articolo in rivista)
    DEL CURATOLO, ANAIS; COGNETTI, FRANCESCO
  • 11573/383579 - 2000 - CA 242 in colo-rectal and pancreatic cancer (04c Atto di convegno in rivista)
    LAURO, SALVATORE; FRATI, LUIGI
  • 11573/383578 - 2000 - CA 72-4, CA 19-9 and CEA in monitoring adjuvant and metastatic colorectal cancer (04c Atto di convegno in rivista)
    LAURO, SALVATORE; FRATI, LUIGI
  • 11573/131489 - 2004 - New approaches to prevent intestinal toxicity of irinotecan-based regimens (01a Articolo in rivista)
    RASIO, DEBORA
  • 11573/108222 - 1999 - COMPARISON OF CEA, MCA, CA 15-3, CA 27-29 IN FOLLOW UP AND MONITORING THERAPEUTIC RESPONSE IN BREAT CANCER PATIENTS (01a Articolo in rivista)
    LAURO, SALVATORE; TRASATTI, LUCIANA; VECCHIONE, ALDO
  • 11573/254256 - 2001 - Malignant bronchial Abrikossoff's tumor and small cell lung cancer: A case report and review (01a Articolo in rivista)
    LAURO, SALVATORE; TRASATTI, LUCIANA; VECCHIONE, ALDO
  • 11573/1347583 - 2019 - Real-World Data on Cabozantinib in Previously Treated Patients with Metastatic Renal Cell Carcinoma: Focus on Sequences and Prognostic Factors (01a Articolo in rivista)
  • 11573/1347591 - 2019 - Be-TeaM: An Italian real-world observational study on second-line therapy for EGFR-mutated NSCLC patients (01a Articolo in rivista)
  • 11573/1348315 - 2006 - Second- and third-generation aromatase inhibitors as first-line endocrine therapy in postmenopausal metastatic breast cancer patients: A pooled analysis of the randomised trials (01a Articolo in rivista)
    COGNETTI, FRANCESCO
  • 11573/1348303 - 2007 - Aromatase inhibitors in post-menopausal metastatic breast carcinoma (01a Articolo in rivista)
    COGNETTI, FRANCESCO
  • 11573/1354273 - 2019 - [Immunotherapy in non-small cell lung cancer patients: back to the future.] (01a Articolo in rivista)
    ROBERTO, MICHELA; BOTTICELLI, ANDREA; COGNETTI, FRANCESCO; GIUSTI, RAFFAELE; NUTI, MARIANNA; MARCHETTI, PAOLO
  • 11573/1242611 - 2019 - Transient disappearance of RAS mutant clones in plasma: A counterintuitive clinical use of EGFR inhibitors in RAS mutant metastatic colorectal cancer (01a Articolo in rivista)
    RAIMONDI, CRISTINA; NICOLAZZO, CHIARA; BELARDINILLI, FRANCESCA; LORENI, FLAVIA; GRADILONE, ANGELA; GIANNINI, GIUSEPPE; MAHDAVIAN, YASAMAN; CORTESI, ENRICO; GAZZANIGA, PAOLA
  • 11573/1416311 - 2020 - ALK Traslocated Pulmonary Sarcomatoid Carcinoma (01i Case report)
  • 11573/1437796 - 2020 - Exploratory pilot study of circulating biomarkers in metastatic renal cell carcinoma (01a Articolo in rivista)
    ZIZZARI, ILARIA GRAZIA; NAPOLETANO, CHIARA; DI FILIPPO, ALESSANDRA; BOTTICELLI, ANDREA; CALABRO', FABIO; URBANO, FEDERICA; POMATI, GIULIA; SCAGNOLI, SIMONE; RUGHETTI, AURELIA; CAPONNETTO, SALVATORE; MARCHETTI, PAOLO; NUTI, MARIANNA
  • 11573/1187954 - 2018 - Use of nivolumab in elderly patients with advanced squamous non–small-cell lung cancer: results from the Italian cohort of an expanded access programme (01a Articolo in rivista)
    MARCHETTI, PAOLO; LIVI, LORENZO
  • 11573/1446124 - 2020 - Efficacy of immunotherapy in lung cancer with co-occurring mutations in NOTCH and homologous repair genes (01a Articolo in rivista)
    MAZZOTTA, MARCO; FILETTI, MARCO; OCCHIPINTI, MARIO; MARINELLI, DANIELE; SCALERA, SIMONA; PALLOCCA, MATTEO; RIZZO, FRANCESCO; BOTTICELLI, ANDREA; SCAFETTA, GIORGIA; DI NAPOLI, ARIANNA; PIZZUTI, LAURA; BARBA, MADDALENA; FANCIULLI, MAURIZIO; CIUFFREDA, LAURA; VECCHIONE, ANDREA; GIUSTI, RAFFAELE; MARCHETTI, PAOLO
  • 11573/1443915 - 2020 - Efficacy and tolerability of selective internal radiotherapy with Yttrium-90 as consolidation treatment after chemotherapy in metastatic colorectal cancer (01a Articolo in rivista)
    CORTESI, ENRICO; CAPONNETTO, SALVATORE; URBANO, FEDERICA; MEZI, SILVIA
  • 11573/1485727 - 2020 - Status of correlation between BMI and response to immunocheck-point inhibitor in advanced non-small-cell lung cancer (01m Editorial/Introduzione in rivista)
    OCCHIPINTI, MARIO; PISEGNA, SIMONA; CORTESI, ENRICO; MARCHETTI, PAOLO
  • 11573/1484476 - 2020 - Immune-related adverse events of pembrolizumab in a large real-world cohort of patients with NSCLC with a PD-L1 expression ≥ 50% and their relationship with clinical outcomes (01a Articolo in rivista)
    MARCHETTI, PAOLO; ZORATTO, FEDERICA; FILETTI, MARCO; OCCHIPINTI, MARIO; SANTINI, DANIELE
  • 11573/1494260 - 2017 - Immunomodulatory effects of tyrosine kinase inhibitors (TKIs) in renal cell carcinoma (RCC) patients (01h Abstract in rivista)
    NUTI, MARIANNA; ZIZZARI, ILARIA GRAZIA; NAPOLETANO, CHIARA; BOTTICELLI, ANDREA; RUGHETTI, AURELIA; UGOLINI, ALESSIO; RUSCITO, ILARY; MAZZUCA, FEDERICA; RAHIMI KOSHKAKI, HASSAN; ONESTI, CONCETTA ELISA; CORTESI, ENRICO; MARCHETTI, PAOLO
  • 11573/1484370 - 2020 - Integrated analysis of concomitant medications and oncological outcomes from PD-1/PD-L1 checkpoint inhibitors in clinical practice (01a Articolo in rivista)
    SANTINI, DANIELE; FILETTI, MARCO; MARCHETTI, PAOLO; BOTTICELLI, ANDREA; OCCHIPINTI, MARIO; MACRINI, SERENA; ZORATTO, FEDERICA
  • 11573/1484353 - 2021 - Effect of concomitant medications with immune-modulatory properties on the outcomes of patients with advanced cancer treated with immune checkpoint inhibitors: development and validation of a novel prognostic index (01a Articolo in rivista)
    SANTINI, DANIELE; FILETTI, MARCO; MARCHETTI, PAOLO; BOTTICELLI, ANDREA; OCCHIPINTI, MARIO; MACRINI, SERENA; ZORATTO, FEDERICA
  • 11573/1529260 - 2021 - The role of opioids in cancer response to immunotherapy (01a Articolo in rivista)
    BOTTICELLI, ANDREA; CIRILLO, ALESSIO; POMATI, GIULIA; CERBELLI, BRUNA; SCAGNOLI, SIMONE; ROBERTO, MICHELA; MAMMONE, GIULIA; CALANDRELLA, MARIA LETIZIA; CERBELLI, EDOARDO; DI PIETRO, FRANCESCA ROMANA; DE GALITIIS, FEDERICA; CORTESI, ENRICO; MEZI, SILVIA; MARCHETTI, PAOLO
  • 11573/1363903 - 2020 - Impact of BMI on HER2+ metastatic breast cancer patients treated with pertuzumab and/or trastuzumab emtansine. Real-world evidence (01a Articolo in rivista)
    PIZZUTI, LAURA; BARCHIESI, GIACOMO; MARCHETTI, PAOLO; BOTTICELLI, ANDREA; MARINELLI, DANIELE; TOMAO, SILVERIO; MAGRI, VALENTINA; CORTESI, ENRICO; SANTINI, DANIELE
  • 11573/1484827 - 2020 - Evaluating the role of FAMIly history of cancer and diagnosis of multiple neoplasms in cancer patients receiving PD-1/PD-L1 checkpoint inhibitors. the multicenter FAMI-L1 study (01a Articolo in rivista)
    ZORATTO, FEDERICA; FILETTI, MARCO; MARCHETTI, PAOLO; BOTTICELLI, ANDREA; OCCHIPINTI, MARIO; SANTINI, DANIELE
  • 11573/1490247 - 2020 - KEAP1-driven co-mutations in lung adenocarcinoma unresponsive to immunotherapy despite high tumor mutational burden (01a Articolo in rivista)
    MARINELLI, DANIELE; MAZZOTTA, MARCO; PALLOCCA, MATTEO; PIZZUTI, LAURA; BARBA, MADDALENA; FILETTI, MARCO; GIUSTI, RAFFAELE; VECCHIONE, ANDREA; OCCHIPINTI, MARIO; BOTTICELLI, ANDREA; CIUFFREDA, LAURA; PESCARMONA, EDOARDO; MARCHETTI, PAOLO
  • 11573/1484842 - 2019 - A multicenter study of body mass index in cancer patients treated with anti-PD-1/PD-L1 immune checkpoint inhibitors: When overweight becomes favorable (01a Articolo in rivista)
    SANTINI, DANIELE; ZORATTO, FEDERICA; FILETTI, MARCO; MARCHETTI, PAOLO; BOTTICELLI, ANDREA; OCCHIPINTI, MARIO
  • 11573/1359830 - 2019 - Adjuvant chemotherapy in resected colon cancer: when, how and how long? (01g Articolo di rassegna (Review))
    CAPONNETTO, SALVATORE; URBANO, FEDERICA; EMILIANI, ALESSANDRA; SCAGNOLI, SIMONE; SIRGIOVANNI, GRAZIA; NAPOLI, VALERIO MARIA; CORTESI, ENRICO
  • 11573/1018172 - 2017 - Burned-out testicular cancer: really a different history? (01i Case report)
    MOSILLO, CLAUDIA; SCAGNOLI, SIMONE; POMATI, GIULIA; CAPONNETTO, SALVATORE; MANCINI, MARIALAURA; BEZZI, MARIO; CORTESI, ENRICO
  • 11573/1347598 - 2020 - Thyroid disorders in programmed death 1 inhibitor-treated patients: Is previous therapy with tyrosine kinase inhibitors a predisposing factor? (01a Articolo in rivista)
    SBARDELLA, EMILIA; TENUTA, MARTA; SIRGIOVANNI, GRAZIA; GIANFRILLI, DANIELE; POZZA, CARLOTTA; VENNERI, MARY ANNA; CORTESI, ENRICO; MARCHETTI, PAOLO; LENZI, ANDREA; ISIDORI, ANDREA
  • 11573/1556637 - 2021 - Intensified total neoadjuvant therapy in patients with locally advanced rectal cancer: a phase II trial (01a Articolo in rivista)
    DE FELICE, FRANCESCA; D'AMBROSIO, GIANCARLO; IAFRATE, FRANCO; MAGLIOCCA, FABIO MASSIMO; CASELLA, GIOVANNI; CLEMENTI, ILARIA; PICCHETTO, ANDREA; PARISI, MARTINA; DE TOMA, GIORGIO; TOMBOLINI, VINCENZO; CORTESI, ENRICO
  • 11573/1568127 - 2021 - Clinical outcomes of NSCLC patients experiencing early immune-related adverse events to PD-1/PD-L1 checkpoint inhibitors leading to treatment discontinuation (01a Articolo in rivista)
    ZORATTO, FEDERICA; FILETTI, MARCO; OCCHIPINTI, MARIO; MACRINI, SERENA; SANTINI, DANIELE
  • 11573/1552033 - 2021 - Smoking status during first-line immunotherapy and chemotherapy in NSCLC patients: a case-control matched analysis from a large multicenter study (01a Articolo in rivista)
    OCCHIPINTI, MARIO; ZORATTO, FEDERICA; FILETTI, MARCO; NAPOLI, VALERIO MARIA
  • 11573/1552037 - 2021 - Evaluation of drug-drug interactions in EGFR-mutated non-small-cell lung cancer patients during treatment with tyrosine-kinase inhibitors (01a Articolo in rivista)
    OCCHIPINTI, MARIO; GIAMMARUCO, MARISTELLA; SIMMACO, MAURIZIO; MARCHETTI, PAOLO
  • 11573/1599252 - 2021 - Impact of sarcopenia and inflammation on patients with advanced non-small cell lung cancer (Ncscl) treated with immune checkpoint inhibitors (icis): a prospective study (01a Articolo in rivista)
    TENUTA, MARTA; PANDOZZI, CARLA; SIRGIOVANNI, GRAZIA; CAMPOLO, FEDERICA; VENNERI, MARY ANNA; CAPONNETTO, SALVATORE; CORTESI, ENRICO; MARCHETTI, PAOLO; ISIDORI, ANDREA; SBARDELLA, EMILIA
  • 11573/1603207 - 2021 - PD-1/PD-L1 checkpoint inhibitors during late stages of life: an ad-hoc analysis from a large multicenter cohort (01a Articolo in rivista)
    SANTINI, DANIELE; GIUSTI, RAFFAELE; FILETTI, MARCO; MARCHETTI, PAOLO; BOTTICELLI, ANDREA; SIRINGO, MARCO; MACRINI, SERENA
  • 11573/1580778 - 2021 - Metastatic renal cell carcinoma management: from molecular mechanism to clinical practice (01g Articolo di rassegna (Review))
    ROBERTO, MICHELA; BOTTICELLI, ANDREA; PANEBIANCO, MARTINA; NUTI, MARIANNA; SANTINI, DANIELE; LAGHI, ANDREA; TOMAO, SILVERIO; MARCHETTI, PAOLO
  • 11573/1634910 - 2022 - Response to immunotherapy in KRAS G12C mutated NSCLC: a single-centre retrospective observational study (01a Articolo in rivista)
    SCIORTINO, CAROLINA; CORTESI, ENRICO; GAZZANIGA, PAOLA; NICOLAZZO, CHIARA; SIRINGO, MARCO; CAPONNETTO, SALVATORE
  • 11573/1620815 - 2022 - High familial burden of cancer correlates with improved outcome from immunotherapy in patients with NSCLC independent of somatic DNA damage response gene status (01f Lettera, Nota)
    GIUSTI, RAFFAELE; FILETTI, MARCO; SANTINI, DANIELE; MARCHETTI, PAOLO; SPINELLI, GIAN PAOLO
  • 11573/1645553 - 2022 - Renal function outcomes in metastatic non-small-cell lung carcinoma patients treated with chemotherapy or immune checkpoint inhibitors: an unexpected scenario (01a Articolo in rivista)
    FLORIS, MATTEO; SCARTOZZI, MARIO; CIRILLO, ALESSIO; BOTTICELLI, ANDREA
  • 11573/1550733 - 2021 - Differential influence of antibiotic therapy and other medications on oncological outcomes of patients with non-small cell lung cancer treated with first-line pembrolizumab versus cytotoxic chemotherapy (01a Articolo in rivista)
    GIUSTI, RAFFAELE; SIRINGO, MARCO; MARCHETTI, PAOLO; FILETTI, MARCO
  • 11573/1484801 - 2020 - Baseline BMI and BMI variation during first line pembrolizumab in NSCLC patients with a PD-L1 expression ≥ 50%. A multicenter study with external validation (01a Articolo in rivista)
    GIUSTI, RAFFAELE; CATINO, ANNA RITA; ZORATTO, FEDERICA; FILETTI, MARCO; FERRARA, MARINA GRAZIA; DE TOMA, ANDREA; ADDEO, ANGELA
  • 11573/1657682 - 2022 - 127P {RAS}, {RAF} and {NF}1 oncogenic mutations in {KRAS}-mutated lung adenocarcinoma (01h Abstract in rivista)
    MARINELLI, DANIELE; PISEGNA, SIMONA; CHIAVASSA, ANTONELLA; BENGALA, ELISABETTA; CAPASSO, CAMILLA; SABATINI, ARIANNA; CIURLUINI, FABIO; ARTEMI, ADELE; TORCHIA, ANDREA; GALLINA, FILIPPO TOMMASO; BOTTICELLI, ANDREA; GAZZANIGA, PAOLA; CORTESI, ENRICO
  • 11573/1667541 - 2021 - 966P Diabetes therapy burden as proxy of impairment of immune checkpoint inhibitors efficacy (01h Abstract in rivista)
    SANTINI, DANIELE; FILETTI, MARCO
  • 11573/1657288 - 2022 - Advanced non-small-cell lung cancer: how to manage EGFR and HER2 exon 20 insertion mutation-positive disease (01a Articolo in rivista)
    SIRINGO, MARCO; MARINELLI, DANIELE
  • 11573/1650247 - 2017 - Comparative effects of Folfirinox and Gemcitabine/nab-paclitaxel as first and second line chemotherapy for metastatic pancreatic cancer: single choice or sequence (01h Abstract in rivista)
    CAPONNETTO, SALVATORE; MAGRI, VALENTINA; SCAGNOLI, SIMONE; POMATI, GIULIA; PIESCO, GABRIELE; PISEGNA, SIMONA; SIRGIOVANNI, GRAZIA; NAPOLI, VALERIO MARIA; BUSCICCHIO, DARIO; MARINELLI, DANIELE; MAMMONE, GIULIA; ASTORINO, VINCENZO; CORTESI, ENRICO
  • 11573/1650241 - 2021 - 3MO Oncogenic non-G12C {KRAS} mutations in {KRAS} G12C mutated lung adenocarcinomas in {TRACERx} and {GENIE}: A reservoir for intrinsic resistance to {KRAS} G12C inhibitors (01h Abstract in rivista)
    MARINELLI, DANIELE; PISEGNA, SIMONA; GIAMMARUCO, MARISTELLA; CHESI, PAOLO; MAMMONE, GIULIA; CEDDIA, SERENA; GAZZANIGA, PAOLA; CORTESI, ENRICO
  • 11573/1667539 - 2021 - 10P Family history of cancer correlates with improved outcome from immunotherapy in NSCLC independent of somatic DNA damage response gene status (01h Abstract in rivista)
    FILETTI, MARCO; GIUSTI, RAFFAELE
  • 11573/1667503 - 2022 - EP08.02-046 Activity of OsimeRTInib in NSCLC with Uncommon EGFR Mutations: Retrospective Observational Multicenter Study (ARTICUNO) (01h Abstract in rivista)
    SIRINGO, MARCO; GIUSTI, RAFFAELE; FILETTI, MARCO
  • 11573/1347609 - 2019 - Bone metastases and immunotherapy in patients with advanced non-small-cell lung cancer (01a Articolo in rivista)
    COGNETTI, FRANCESCO
  • 11573/969802 - 2017 - Prolactin as a Potential Early Predictive Factor in Metastatic Non-Small Cell Lung Cancer Patients Treated with Nivolumab (01a Articolo in rivista)
    CAPONNETTO, SALVATORE; BARCHIESI, GIACOMO; MAGRI, VALENTINA; CORTESI, ENRICO
  • 11573/1394000 - 2020 - The agnostic role of site of metastasis in predicting outcomes in cancer patients treated with immunotherapy (01a Articolo in rivista)
    BOTTICELLI, ANDREA; CIRILLO, ALESSIO; SCAGNOLI, SIMONE; CERBELLI, BRUNA; DE GALITIIS, FEDERICA; D'AMATI, GIULIA; MEZI, SILVIA; NUTI, MARIANNA; MARCHETTI, PAOLO
  • 11573/1307277 - 2020 - Distinct HR expression patterns significantly affect the clinical behavior of metastatic HER2+ breast cancer and degree of benefit from novel anti-HER2 agents in the real world setting (01a Articolo in rivista)
    PIZZUTI, LAURA; BARCHIESI, GIACOMO; MARCHETTI, PAOLO; MAZZOTTA, MARCO; GIUSTI, RAFFAELE; BOTTICELLI, ANDREA; TOMAO, SILVERIO; TOMAO, FEDERICA; SANTINI, DANIELE; MENTUCCIA, LUCIA; MAGRI, VALENTINA; CORTESI, ENRICO; FABBRI, MARIA AGNESE; D'AURIA, GIULIANA; SINI, VALENTINA; LIVI, LORENZO; DE MARIA MARCHIANO, RUGGERO; RISI, EMANUELA; SPERDUTI, ISABELLA; BARBA, MADDALENA
  • 11573/1348287 - 2012 - Molecular and genetic bases of pancreatic cancer (01a Articolo in rivista)
    COGNETTI, FRANCESCO
  • 11573/1600648 - 2022 - Circulating CD137 + T cells correlate with improved response to anti-PD1 immunotherapy in cancer patients (01a Articolo in rivista)
    ZIZZARI, ILARIA GRAZIA; DI FILIPPO, ALESSANDRA; BOTTICELLI, ANDREA; PERNAZZA, ANGELINA; RULLO, EMMA; PIGNATARO, MARIA GEMMA; UGOLINI, ALESSIO; SCIROCCHI, FABIO; DI PIETRO, FRANCESCA ROMANA; D'AMATI, GIULIA; RUGHETTI, AURELIA; MARCHETTI, PAOLO; NUTI, MARIANNA; NAPOLETANO, CHIARA
  • 11573/1601270 - 2021 - Comparison of two blood-based genotyping tests to investigate the KRAS G12C mutation in patients with non-small-cell lung cancer at failure of first-line treatments (01a Articolo in rivista)
    NICOLAZZO, CHIARA; BOTTILLO, IRENE; BELARDINILLI, FRANCESCA; PISEGNA, SIMONA; DE RENZI, GIANLUIGI; MARINELLI, DANIELE; GRAMMATICO, PAOLA; CORTESI, ENRICO; GIANNINI, GIUSEPPE; GAZZANIGA, PAOLA

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