ADELE ROMANO
Date of birth: November 8th, 1983
Place of birth: Naples, Italy
Married, with two children (2015 and 2019)
Current Position: Associate Professor of Pharmacology, Sapienza University of Rome
WORK ADDRESS:
Dept. of Physiology and Pharmacology “V. Erspamer”, Sapienza University of Rome, Italy
Piazzale Aldo Moro, 5 – 00185 Rome, Italy
Tel: +39 06 4991 2520
Fax: +39 06 4991 2480
Email address: adele.romano@uniroma1.it
EDUCATION
-2007: Master in Biological Pharmacy 110/110, School of Pharmacy, University of Naples, “Federico II”, Italy
-2007: Board Certified Pharmacist University of Naples, “Federico II”, Italy
-2011: PhD in Toxicology, Sapienza University of Rome, Italy
-2007-2010: Pre-doctorate training (3-year-training on neuropsychopharmacology using different animal models of eating disorders, obesity and Alzheimer’s disease). Dept. of Physiology and Pharmacology “V. Erspamer”, Sapienza University of Rome Italy, School of Pharmacy and Medicine
-2009: Pre-doctorate training. Short-term training as visiting student at the Toxicology Unit of the University of Leicester, UK
OTHER QUALIFICATIONS
2005 Certificate in English knowledge, University of Cambridge, UK
2011 Felasa Licence cat B for experimental procedures on laboratory animals, EBRI Foundation
2012 Licence for Surgery course on laboratory rats, Institute of Food Nutrition and Health, Physiology and Behaviour Laboratory, ETH Zurich, Switzerland
ACADEMIC HISTORY
Feb 2011-July 2012 Post-Doc at the Department of Biomedical Sciences and Public Health University Politecnica delle Marche, Ancona Italy. School of Medicine and Surgery
Feb 2012-July 2012 Guest Researcher at the Institute of Veterinary Physiology
University of Zurich, Switzerland
Dec 2012-Nov 2013 Post-Doc at the Department of Physiology and Pharmacology, School of Pharmacy and Medicine Sapienza University of Rome, Italy
Jan 2014-Dec 2014 Post-Doc at the Department of Physiology and Pharmacology, School of Pharmacy and Medicine Sapienza University of Rome, Italy
Jan 2015-May 2016 Post-Doc at the Department of Physiology and Pharmacology, School of Pharmacy and Medicine Sapienza University of Rome, Italy
June 2016-May 2017 Post-Doc at the Department of Physiology and Pharmacology, School of Pharmacy and Medicine Sapienza University of Rome, Italy
June 2017-May 2018 Post-Doc at the Department of Physiology and Pharmacology, School of Pharmacy and Medicine Sapienza University of Rome, Italy
March 2017 National Scientific Qualification as Associate Professor in Pharmacology (Abilitazione Scientifica Nazionale per Professore II fascia SSD BIO/14 SSC 05/G1)
June 2018-June 2019 Post-Doc at the Department of Physiology and Pharmacology, School of Pharmacy and Medicine Sapienza University of Rome, Italy
July 2019-May 2022 Assistant Professor of Pharmacology (Ricercatore a tempo determinato tipologia B) at the Department of Physiology and Pharmacology, School of Pharmacy and Medicine Sapienza University of Rome, Italy
July 2022-present Associate Professor of Pharmacology at the Department of Physiology and Pharmacology, School of Pharmacy and Medicine Sapienza University of Rome, Italy
February 2023 National Scientific Qualification as Full Professor in Pharmacology (Abilitazione Scientifica Nazionale per Professore I fascia SSD BIO/14 SSC 05/G1)
MANDATORY MATERNITY LEAVE (L. 1204/1971)
from 27/02/2015 to 28/07/2015 (5 months)
from 28/01/2019 to 28/06/2019 (5 months)
AWARDS AND HONORS
2010 Travel award of the Italian Society of Pharmacology, to attend the 16th World Congress of Basic and Clinical Pharmacology, Copenhagen
2010 Travel award of GDRE-691, to participate to the Summer School of GDRE-691: “Early Programming of Adult Modern Diseases”, Lille France
2012 Travel award of the European Behavioural Pharmacology Society (EBPS), to attend (as invited speaker) the Workshop on “Eating Behaviour and Obesity”, September, 2012 Lecce, Italy
2012 6- months scholarship (1000 Euro) of the Italian Society of Pharmacology for selected young researchers to attend international laboratories
2013 Travel award (1.000 $) of the Society for the Study of Ingestive Behavior (SSIB), to attend (as invited speaker) the 21st Annual Meeting of the Society for the Study of Ingestive Behavior. New Orleans, LA
2013 Best poster Award (500 Euro) of the Italian Society of Pharmacology during the national meeting of the Italian Society of Pharmacology, Torino, Italy
2015 Travel award (500 Euro) of the Italian Society for Neuroscience (SINS) to attend (as invited speaker) the 16th Congress for the SINS, Cagliari, Italy
2017 Travel award (500 Euro) of the Italian Society for Neuroscience (SINS) to attend (as invited speaker) the 17th Congress for the SINS, Ischia, Italy
2017 Farmaindustria Award (5.000 Euro) of the Italian Society of Pharmacology (SIF) for young researchers for their scientific achievements
2017 Best poster Award (500 Euro) of the Italian Society of Pharmacology during the national meeting of the Italian Society of Pharmacology, Rimini, Italy
2017 “Alberigo Benedicenti” Award (2.000 Euro) of the University of Florence, Italy to Young Pharmacology Experts (“Cultori della materia”), who have demonstrated the best scientific activity in the field of pharmacology and toxicology studies during the years 2014-2016.
2018 Winner of a Teaching assignments for staff Mobility within the framework of the Erasmus Swiss-European Mobility Programme 2017/2018 (amount credited 1.350 CHF).
2018 Certificate of merit for being classified among the 10 best project proposals received (out of 400 proposals) for the L'Oréal Italy-UNESCO “For Women in Science” 2017/2018 Edition.
RESEARCH GRANTS OBTAINED AS PRINCIPAL INVESTIGATOR
2014: Intramural research grant, Sapienza University of Rome € 3.000
Title of the research: The role of the area postrema in the anorectic effects of oleoylethanolamide: behavioral and neuronal phenotyping.
2016: Intramural research grant, Sapienza University of Rome € 2.000
Title of the research: Effetto del trattamento cronico con oleoiletanolammide sul comportamento alimentare e sul microbiota intestinale in un modello animale di obesità indotta dalla dieta
2017: Intramural research grant, Sapienza University of Rome € 2.250
Title of the research: Effects of Oleoylethanolamide on mesolimbic dopaminergic transmission in an animal model of binge eating
2018: Intramural research grant, Sapienza University of Rome € 2.000
Title of the research: Effetti dell'oleoiletanolamide sull'attivazione di aree centrali e sul sitema di neurotrasmissione monoaminergico in un modello sperimentale di "Binge Eating Disorder"
2021: Progetti di Rilevante Interesse Nazionale (PRIN) Italian National Research Grant €
175.157
Title of the research: Regulation of autophagy by N-acylethanolamines as a promising approach for the treatment of inflammatory-based diseases: from neurodegeneration to metabolic disorders.
2022: Banca d’Italia € 30.000
Title of the research: Regulation of autophagy by N-acylethanolamines as a promising approach for the treatment of inflammatory-based diseases: from neurodegeneration to metabolic disorders
RESEARCH GRANTS OBTAINED AS PARTICIPANT
2009-2011
Partecipante al Progetto di Ricerche Universitarie dal titolo "Effetti dell'ischemia cerebrale sul sistema endocannabinoide: studio delle alterazioni comportamentali e biochimiche" finanziato dalla SAPIENZA Università di Roma – anno 2009 - prot. C26A0947LW (principal investigator Prof. Vincenzo Cuomo).
2007-2011
Partecipante al Progetto di Ricerca FIRB PIATTAFORME/RETI 2006 (CHEM-PROFARMA-NET) finanziato dal MIUR. Codice Modello B: RBPR05NWWC_12. Titolo del progetto: Ricerca e Sviluppo del Farmaco (CHEM-PROFARMA-NET). Sintesi, caratterizzazione biologica e farmacologica di nuove molecole organiche, bioorganiche e naturali ad attività antidegenerativa (neuro o cardiovascolare), immunomodulatrice, antivirale ed anti-infettiva.
2013-2015
Partecipante al Progetto di Ricerche Universitarie dal titolo "Cognitive decline and neuropsychiatric syntoms in Alzheimer’s disease: can endocannabinoids help?” finanziato dalla SAPIENZA Università di Roma – anno 2013 - prot. C26A13389Y (principal investigator Prof.ssa Silvana Gaetani).
2013-2017
Partecipante al progetto FIRB dal titolo “Studio dei meccanismi epigenetici coinvolti nei disordini alimentari e nell'obesità per la scoperta di nuovi target farmacologici” finanziato dal MIUR (principal investigator Prof.ssa Silvana Gaetani). Codice: RBFR12DELS_003 CUP: B81J12003240001
SCIENTIFIC RECORDS
https://www.scopus.com/authid/detail.uri?authorId=56000580300
OTHER SCIENTIFIC ACTIVITIES:
-2021: Chair of the Scientific Organizing Committee of a Symposium within the meeting of the Italian Society of Pharmacology: “New possible pharmacological targets for the treatment of eating disorders”, digital edition.
-2021: winner of a Symposia proposal under 40 within the meeting of the Italian Society for Neuroscience. Symposium title: “The inflamed brain in neurological diseases: moving from hypothesis to treatment”. Organizers symposium: Adele Romano and Irene Paterniti.
-2021: Chair of the Scientific Organizing Committee of a Symposium within the meeting of the Italian Society for Neuroscience “The inflamed brain in neurological diseases: moving from hypothesis to treatment”, virtual congress.
-2015-present: referee of numerous scientific journals, including high impact journals.
-2020-present: member of the Review Editorial Board of the Journal “Frontiers in Pharmacology” (Experimental Pharmacology and Drug Discovery).
-2020-present: member of the scientific group “Obesity, Metabolic Syndrome and Eating disorders” of the Italian Society of Pharmacology
-2021: Guest Editor for the special issue of the “International Journal of Molecular Sciences” titled “Therapeutic Potential of Targeting the Oxytocinergic System”.
TEACHING ACTIVITY
-Research supervisor for undergraduate students of Pharmaceutical Biotechnology, Faculty of Pharmacy and Medicine, Sapienza University of Rome, Italy 2013-2015
- Member of the exam committee (cultore della materia), of the course of Pharmacology, Pharmacotherapy and Pharmaceutical Biotechnologies, Faculty of Pharmacy and Medicine Sapienza University of Rome, Italy 2013-present
- Lecture on laboratory techniques for undergraduate students of the Master Course in Medicinal Chemistry Faculty of Pharmacy and Medicine Sapienza University of Rome, Italy 2012 and 2014
- Lecture in Pharmacology for undergraduate students of the Master Course in Pharmaceutical Biotechnologies Faculty of Pharmacy and Medicine Sapienza University of Rome, Italy 2013 and 2014
- Lecture in Physiology of eating behaviour for undergraduate students of the Master Course in Pharmacy, Faculty of Pharmacy and Medicine Sapienza University of Rome, Italy 2014 and 2015
- Lectures (8 hours) in Pharmacology for undergraduate students of the Master Course in Pharmaceutical Biotechnologies, Faculty of Pharmacy and Medicine Sapienza University of Rome, Italy 2015
- Lectures (8 hours) in Pharmacology for undergraduate students of the Master Course in Pharmaceutical Biotechnologies, Faculty of Pharmacy and Medicine Sapienza University of Rome, Italy 2016
- Lectures (23 hours) on Pharmacology for undergraduate students of the Master Course in Medicinal Chemistry, Faculty of Pharmacy and Medicine Sapienza University of Rome, Italy 2017
- Course on in vivo laboratory techniques for PhD students of the PhD Program of Pharmacology and Toxicology, Sapienza University of Rome, Italy 2017
- Course on pharmacology (Title: regulation of eating behaviour and pharmacological targets for the treatment of eating disorders) for PhD students of the course of Pharmacology and Toxicology, Sapienza University of Rome, Italy 2018
- Lectures (12 hours) on Pharmacology for undergraduate students of the Master Course in Pharmacy, Sapienza University of Rome, Italy 2018
- Course owner of the lectures on Pharmacology (8 hours), Title: “Searching for novel pharmacological targets for the treatment of obesity” for PhD student of the PhD Program in Pharmacology and Veterinary Physiology of the University of Zurich, Institute of Veterinary Physiology, Vetsuisse Faculty University of Zurich, Switzerland, 2018.
- Course of in vivo techniques for the evaluation of xenobiotic activity” for PhD students of the course of Pharmacology and Toxicology, Sapienza University of Rome, Italy 2019-present
-Course owner of the Course of “General Pharmacology and Pharmacotherapy” for undergraduate students of the Master Course in “Applied Pharmaceutical Sciences” Faculty of Pharmacy and Medicine Sapienza University of Rome, Italy Jenuary 2019- December 2022.
- Course owner of the Course of “Pharmacologic sciences” for undergraduate students of the Master Course in “Scientific Biomedical Communication”, Faculty of Pharmacy and Medicine Sapienza University of Rome, Italy October 2020-September 2022.
- Course owner of the Course of “Pharmacologic” for undergraduate students of the Master Course in “Orthoptic and ophtalmologic assistance”, Faculty of Pharmacy and Medicine Sapienza University of Rome, Italy October 2021- September 2022.
- Course owner of the Course of “Toxicology” for undergraduate students of the Master Course in “Pharmacy”, Faculty of Pharmacy and Medicine Sapienza University of Rome, October 2022- present
- Course owner of the Course of “Pharmacovigilance and Toxicology” for undergraduate students of the Master Course in “Applied Pharmaceutical Sciences” Faculty of Pharmacy and Medicine Sapienza University of Rome, Italy October 2022- present.
-Curse owner of the Course of Pharmacology at the graduate school in ophthalmology, Faculty of Medicine and Surgery, Sapienza University of Rome, Italy, November 2021-present
MENTORSHIP ACTIVITY (2005-PRESENT)
-Mentor of 1 PhD students at Sapienza Univ. of Rome (2021-present)
-Mentor of 10 master thesis in Applied Pharmaceutical Sciences and Scientific Biomedical Communication, at Sapienza University of Rome (2020-present)
-Research supervisor (co-relatore) of master students’ theses (more than 10) in Pharmaceutical Biotechnology, Medicinal Chemistry, Pharmacy at Sapienza University of Rome (2013-present)
OTHER ACADEMIC ACTIVITIES
-2017-present: Member of the Board of Professors of the Ph.D program in Pharmacology and Toxicology, Sapienza University of Rome
- November 2020-present: Nominated secretary of the “Consiglio del Corso di Studi” of the course of Applied Pharmaceutical Sciences, Faculty of Pharmacy and Medicine, Sapienza University of Rome.
-January 2022-present: nominated member of the Quality Committee of the course of Applied Pharmaceutical Sciences, Faculty of Pharmacy and Medicine, Sapienza University of Rome.
LIST OF PUBBLICATIONS
1. Gaetani S, Dipasquale P, Romano A, Righetti L, Cassano T, Piomelli D. and Cuomo V. The endocannabinoid system as a target for novel anxiolytic and antidepressant drugs. International Review of Neurobiology 2009, 85:57-72. I.F. 4.017
2. Gaetani S, Fu J, Cassano T, Dipasquale P, Romano A, Righetti L, Cianci S, Laconca L, Giannini E, Scaccianoce S, Mairesse J, Cuomo V, and Piomelli D. The fat-induced satiety factor OEA suppresses feeding through central release of oxytocin. Journal of Neuroscience 2010, 30:8096-101. I.F. 7.271
3. Cassano T, Gaetani S, Macheda T, Laconca L, Romano A, Morgese MG, Cimmino CS, Chiarotti F, Bambico FR, Gobbi G, Cuomo V, and Piomelli D. Evaluation of the emotional phenotype and serotonergic neurotransmission of fatty acid amide hydrolase-deficient mice. Psychopharmacology 2011, 214:465-76. I.F. 4.077
4. Dipasquale P*, Romano A*, Cianci S, Rigetti L, Gaetani S. Oleoylethanolamide: a new player in energy metabolism control. Role in Food intake. Drug Discovery Today: Disease Mechanisms. 2010, 7: e169–e174. *equal contribution. No impact
5. Cassano T*, Romano A*, Macheda T, Colangeli R, Petrella A, LaFerla FM, Cuomo V, Gaetani S. Olfactory memory is impaired in a triple transgenic model of Alzheimer disease. Behavioural Brain Research 2011, 224:408-12. *equal contribution. I.F. 3.417
6. Cassano T, Serviddio G, Gaetani S, Romano A, Dipasquale P, Cianci S, Bellanti F, Laconca L, Romano AD, Padalino I, LaFerla FM, Nicoletti F, Cuomo V, Vendemiale G. Glutamatergic alterations and mitochondrial impairment in a murine model of Alzheimer disease. Neurobiology of Aging 2012, 33:1121 e1-12. I.F. 6.166
7. Romano A, Cassano T, Tempesta B, Cianci S, Dipasquale P, Coccurello R, Cuomo V, Gaetani S. The satiety signal oleoylethanolamide stimulates oxytocin neurosecretion from rat hypothalamic neurons. Peptides 2013, 49:21-6. I.F. 2.614
8. Romano A, Potes C, Tempesta B, Cassano T, Cuomo V, Lutz T, and Gaetani S. Hindbrain noradrenergic input to the hypothalamic PVN mediates the activation of oxytocinergic neurons induced by the satiety factor oleoylethanolamide. American Journal of Physiology, Endocrinology and Metabolism 2013, 305(10):E1266-73. I.F. 4.088
9. Aureli C, Cassano T, Masci A, Francioso A, Martire S, Cocciolo A, Chichiarelli S, Romano A, Gaetani S, Mancini P, Fontana M, d'Erme M, Mosca L. 5-S-Cysteinyldopamine neurotoxicity: influence on the expression of alpha-Synuclein and of ERp57 in cellular and animal models of Parkison’s disease. Journal of Neuroscience Research 2014, 92(3):347-58. I.F. 2.594
10. Bedse G*, Romano A*, Cianci S, Lavecchia AM, Pace L, Elphick MR, LaFerla FM, Vendemiale G, Grillo C, Altieri F, Cassano T and Gaetani S. Altered expression of the CB1 cannabinoid receptor in the triple transgenic mouse model of Alzheimer’s disease. Journal of Alzheimer’s disease 2014, 40 (3):701-12 *equal contribution I.F. 4.151
11. Romano A, Coccurello R, Giacovazzo G, Bedse G, Moles A, Gaetani S. Oleoylethanolamide: a novel potential pharmacological alternative to cannabinoid antagonists for the control of appetite. BioMed Research International, 2014, 2014:203425. I.F. 1.579
12. Romano A*, Karimian Azari E, Tempesta B, Mansouri A, Micioni Di Bonaventura MV, Ramachandran D, Lutz TA, Bedse G, Langhans W, Gaetani S*. High dietary fat intake influences the activation of specific hindbrain and hypothalamic nuclei by the satiety factor oleoylethanolamide. Physiology and Behaviour, 2014, 136:55-62. * co-corresponding authors I.F. 2.976
13. Karimian Azari E, Ramachandran D, Weibel S, Arnold M, Romano A, Gaetani S, Langhans W, Mansouri A. Vagal afferents are not necessary for the satiety effect of the gut lipid messenger oleoylethanolamide (OEA). The American Journal of Physiology Regulatory, Integrative and Comparative Physiology, 2014, 307(2): R167-78. I.F. 3.106
14. Provensi G, Munari L, Umehara H, Coccurello R, Giacovazzo G, Galeotti N, Nosi D, Gaetani S, Romano A, Moles A, Blandina P and Passani MB. Satiety factor oleoylethanolamide recruits the brain histaminergic system to inhibit food intake. Proceedings of the National Academy of Sciences, 2014, 111(31): 11527-32. I.F. 9.674
15. Romano A, Pace L, Tempesta B, Lavecchia AM, Macheda T, Bedse G, Petrella A, Vendemiale G, Gaetani S, Cassano T. Depressive-like behaviour is paired to monoaminergic alteration in a murine model of Alzheimer's disease. International journal of Neuropsycopharmacology 2014, 18(4). I.F. 4.009
16. Bedse G, Colangeli R, Lavecchia AM, Romano A, Altieri F, Cifani C, Cassano T, Gaetani S. Role of the basolateral amygdala in mediating the effects of the fatty acid amide hydrolase inhibitor URB597 on HPA axis response to stress. European Neurophsycopharmacology, 2014, 24:1511-23. I.F. 4.639
17. Micioni Di Bonaventura MV, Ciccocioppo R, Romano A, Bossert J, Rice K, Ubaldi M, St. Laurent R, Gaetani S, Massi M, Shaham Y, Cifani C. Role of bed nucleus of the stria terminalis corticotrophin-releasing factor receptors in frustration stress-induced binge-like palatable food consumption in female rats with a history of food restriction. Journal of Neuroscience, 2014, 34 :11316-24. I.F. 6.344
18. D'Addario C, Micioni di Bonaventura MV, Pucci M, Romano A, Gaetani S, Ciccocioppo R, Cifani C, Maccarrone M. Endocannabinoid signaling and food addiction. Neuroscience & Biobehavioral Reviews, 2014, 47:203-24. I.F. 8.802
19. Bedse G, Romano A, Lavecchia AM, Cassano T and Gaetani S. The role of endocannabinoid signaling in the molecular mechanisms of neurodegeneration in Alzheimer disease. Journal of Alzheimer’s disease, 2015, 43(4):1115-36. I.F. 3.920
20. Bedse G, Romano A, Tempesta B, Lavecchia MA, Pace L, Bellomo A, Duranti A, Micioni di Bonaventura MV, Cifani C, Cassano T, Gaetani S. Inhibition of anandamide hydrolysis enhances noradrenergic and GABAergic transmission in the prefrontal cortex and basolateral amygdala of rats subjected to acute swim stress. Journal of Neuroscience Research, 2015, 93:777-87. I.F. 2.689
21. Cifani C, Micioni Di Bonaventura MV, Pucci M, Giusepponi ME, Romano A, Di Francesco A, Maccarrone M, D'Addario C. Regulation of hypothalamic neuropeptides gene expression in diet induced obesity resistant rats: possible targets for obesity prediction? Frontiers in Neuroscience, 2015, 9:187. I.F. 3.398
22. Romano A, Tempesta B, Provensi G, Passani MB, Gaetani S. Central mechanisms mediating the hypophagic effects of oleoylethanolamide and N-acylphosphatidylethanolamines: different lipid signals? Frontiers in Pharmacology, 2015, 6: 137. I.F. 4.418
23. Giudetti A, Romano A, Lavecchia M, Gaetani S.The role of brain cholesterol and its oxidized products in Alzheimer's disease. Current Alzheimer Research, 2016, 13:198-205. I.F. 2.952
24. Pucci M, Micioni Di Bonaventura MV, Giusepponi ME, Romano A, Filaferro M, Maccarrone M, Ciccocioppo R, Cifani C, D’Addario C. Epigenetic regulation of nociceptin/orphanin FQ and corticotropin-releasing factor system genes in frustration stress-induced binge-like palatable food consumption. Addiction Biology, 2016, 21:1168-1185. I.F. 4.603
25. Romano A, Tempesta B, Micioni Di Bonaventura MV, Gaetani S. From autism to eating disorders and more: the role of oxytocin in neuropsychiatric disorders. Frontiers in Neuroscience, 2016, 9:497. I.F. 3.566
26. Gaetani S, Romano A, Provensi G, Ricca V, Lutz T, Passani MB. Eating disorders: from bench to bedside and back. Journal of Neurochemistry. 2016, 139(5):691-699. I.F. 4.083
27. Romano A, Koczwara JB, Gallelli CA, Vergara D, Bonaventura MV, Gaetani S, Giudetti AM. Fats for thoughts: An update on brain fatty acid metabolism. The International Journal of Biochemistry & Cell Biology. 2017, 84:40-45. I.F. 3.247
28. Romano A, Serviddio G, Calcagnini S, Villani R, Giudetti AM, Cassano T, Gaetani S. Linking lipid peroxidation and neuropsychiatric disorders: focus on 4-hydroxy-2-nonenal. Free Radical Biology & Medicine 2017, 111:281-293. I.F. 6.020
29. Micioni Di Bonaventura MV, Lutz TA, Romano A, Pucci M, Geary N, Asarian L, Cifani C. Estrogenic suppression of binge-like eating elicited by cyclic food restriction and frustrative nonreward stress in female rats. International Journal of eating disorders, 2017, 50(6):624-635. I.F. 3.897
30. Cassano T, Calcagnini S, Pace L, De Marco F, Romano A, Gaetani S. Cannabinoid receptor 2 signaling in neurodegenerative disorders: from pathogenesis to a promising therapeutic target. Frontiers in Neuroscience, 2017, 11:30. I.F. 3.877
31. Bellanti F, Iannelli G, Blonda M, Tamborra R, Villani R, Romano A, Mazzoccoli G, Vinciguerra M, Vendemiale G, Cassano T, Serviddio G. Alterations of clock gene RNA expression in brain regions of the triple transgenic model of Alzheimer Disease. Journal of Alzheimer’s disease, 2017, 017;59(2):615-631. I.F. 3.476
32. Romano A, Gallelli CA, Koczwara JB, Braegger FE, Micioni Di Bonaventura MV, Cifani C, Lutz TA, Vitalone A, Falchi M, Cassano T, Gaetani S. Role of the area postrema in the hypophagic effects of oleoylethanolamide. Pharmacological Research, 2017, 122:20-34. I.F. 4.897
33. Roberto Coccurello*, Romano A*, Giacovazzo G, Tempesta B, Fiore M, Giudetti AM, Marrocco I, Altieri F, Moles A, Gaetani S. Increased intake of energy-dense diet and negative energy balance in a mouse model of chronic psychosocial defeat. European Journal of Nutrition, 2018, 57(4):1485- 1498. *equal contribution I.F. 4.449
34. Bronzuoli MR, Facchinetti R, Steardo L Jr, Romano A, Stecca C, Passarella S, Steardo L, Cassano T, Scuderi C. Palmitoylethanolamide dampens reactive astrogliosis and improves neuronal trophic support in a triple transgenic model of Alzheimer’s disease: in vitro and in vivo evidence. Oxidative Medicine and Cellular Longevity, 2018, 4720532. I.F. 4.868
35. Giudetti AM, Testini M, Vergara D, Priore P, Damiano F, Gallelli CA, Romano A, Villani R, Cassano T, Siculella L, Gnoni GV, Moles A, Coccurello R, Gaetani S. Chronic psychosocial defeat differently affects lipid metabolism in liver and white adipose tissue and induces hepatic oxidative stress in mice fed a high-fat diet. The FASEB Journal 2018, in press. doi: 10.1096/fj.201801130R I.F. 5.391
36. Gallelli CA, Calcagnini S, Romano A, Koczwara JB, de Ceglia ML, Dante D, Villani R, Giudetti AM, Cassano T, Gaetani S. Modulation of the Oxidative Stress and Lipid Peroxidation by Endocannabinoids and Their Lipid Analogues. Antioxidants (Basel), 2018, 7 (7). doi: 10.3390/antiox7070093. I.F. 4.520
37. Micioni Di Bonaventura MV, Pucci M, Giusepponi ME, Romano A, Lambertucci C, Volpini R, Micioni Di Bonaventura E, Gaetani S, Maccarrone M, D'Addario C, Cifani C. Regulation of adenosine A(2A) receptor gene expression in a model of binge eating in the amygdaloid complex of female rats. Journal of Psychopharmacology. 2019 Jun 4:269881119845798. doi: 10.1177/0269881119845798. I.F.3.121
38. Cassano T, Magini A, Giovagnoli S, Polchi A, Calcagnini S, Pace L, Lavecchia MA, Scuderi C, Bronzuoli MR, Ruggeri L, Gentileschi MP, Romano A, Gaetani S, De Marco F, Emiliani C, Dolcetta D. Early intrathecal infusion of everolimus restores cognitive function and mood in a murine model of Alzheimer's disease. Experimental Neurology 2019 Jan; 311:88-105. doi: 10.1016/j.expneurol.2018.09.011. I.F. 4.691
39. Cassano T, Calcagnini S, Carbone A, Bukke VN, Orkisz S, Villani R, Romano A, Avolio C, Gaetani S. Pharmacological Treatment of Depression in Alzheimer's Disease: A Challenging Task. Frontiers in Pharmacology. 2019 Sep 27;10:1067. doi: 10.3389/fphar.2019.01067. eCollection 2019. I.F. 4.225
40. Cifani C, Avagliano C, Micioni Di Bonaventura E, Giusepponi ME, De Caro C, Cristiano C, La Rana G, Botticelli L, Romano A, Calignano A, Gaetani S, Micioni Di Bonaventura MV, Russo R. Modulation of Pain Sensitivity by Chronic Consumption of Highly Palatable Food Followed by Abstinence: Emerging Role of Fatty Acid Amide Hydrolase. Frontiers in Pharmacology. 2020 Mar 16;11:266. doi: 10.3389/fphar.2020.00266. eCollection 2020. I.F. 5.811
41. Romano A, Friuli M, Cifani C, Gaetani S. Oxytocin in the neural control of eating: At the crossroad between homeostatic and non-homeostatic signals. Neuropharmacology. 2020 Apr 4;171:108082. doi: 10.1016/j.neuropharm.2020.108082. I.F. 5.251
42. Romano A*, Micioni Di Bonaventura MV*, Gallelli CA, Koczwara JB, Smeets D, Giusepponi ME, De Ceglia M, Friuli M, Micioni Di Bonaventura E, Scuderi C, Vitalone A, Tramutola A, Altieri F, Lutz TA, Giudetti AM, Cassano T, Cifani C, Gaetani S. Oleoylethanolamide decreases frustration stress-induced binge-like eating in female rats: a novel potential treatment for binge eating disorder. Neuropsychopharmacology. 2020 Apr 30. doi: 10.1038/s41386-020-0686-z. *equal contribution I.F. 7.855
43. Anna Maria Giudetti, Maria Vittoria Micioni, Di Bonaventura, Alessandra Ferramosca, Serena Longo, Emanuela Micioni Di Bonaventura, Marzia Friuli, Adele Romano, Silvana Gaetani, Carlo Cifani. Brief daily access to cafeteria-style diet impairs hepatic metabolism even in the absence of excessive body weight gain in rats. The FASEB Journal. 2020 Jul;34(7):9358-9371. doi:10.1096/fj.201902757R. I.F. 5.192
44. Luca Botticelli, Emanuela Micioni Di Bonaventura, Fabio Del Bello, Gianfabio Giorgioni, Alessandro Piergentili, Adele Romano, Wilma Quaglia, Carlo Cifani, Maria Vittoria Micioni Di Bonaventura. Underlying Susceptibility to Eating Disorders and Drug Abuse: Genetic and Pharmacological Aspects of Dopamine D4 Receptors. Nutrients. 2020 Jul 30;12(8):2288. doi: 10.3390/nu12082288. I.F. 5.719
45. Romano A, Friuli M, Del Coco L, Longo S, Vergara D, Del Boccio P, Valentinuzzi S, Cicalini I, Fanizzi FP, Gaetani S, Giudetti AM. Chronic Oleoylethanolamide Treatment Decreases Hepatic Triacylglycerol Level in Rat Liver by a PPARγ/SREBP-Mediated Suppression of Fatty Acid and Triacylglycerol Synthesis. Nutrients. 2021 Jan 27;13(2):394. doi: 10.3390/nu13020394. I.F. 5.719
46. Rani B, Santangelo A, Romano A, Koczwara JB, Friuli M, Provensi G, Blandina P, Casarrubea M, Gaetani S, Passani MB, Costa A. Brain histamine and oleoylethanolamide restore behavioral deficits induced by chronic social defeat stress in mice. Neurobiology of Stress. 2021 Mar 17;14:100317. doi: 10.1016/j.ynstr.2021.100317. I.F. 5.441
47. Conte E, Romano A, De Bellis M, de Ceglia M, Rosaria Carratù M, Gaetani S, Maqoud F, Tricarico D, Camerino C. Oxtr/TRPV1 expression and acclimation of skeletal muscle to cold-stress in male mice. Journal of Endocrinology. 2021 May;249(2):135-148. doi: 10.1530/JOE-20-0346. I.F. 4.286
48. Giudetti AM, Vergara D, Longo S, Friuli M, Eramo B, Tacconi S, Fidaleo M, Dini L, Romano A*, Gaetani S*. Oleoylethanolamide Reduces Hepatic Oxidative Stress and Endoplasmic Reticulum Stress in High-Fat Diet-Fed Rats. Antioxidants (Basel). 2021 Aug 14;10(8):1289. doi: 10.3390/antiox10081289. *equal contribution I.F. 6.313
49. Baldi E, Costa A, Rani B, Passani MB, Blandina P, Romano A, Provensi G. Oxytocin and Fear Memory Extinction: Possible Implications for the Therapy of Fear Disorders? International Journal of Molecular Sciences. 2021 Sep 16;22(18):10000. doi: 10.3390/ijms221810000. I.F. 5.924
50. Friuli M, Eramo B, Valenza M, Scuderi C, Provensi G, Romano A*. Targeting the Oxytocinergic System: A Possible Pharmacological Strategy for the Treatment of Inflammation Occurring in Different Chronic Diseases. International Journal of Molecular Sciences. 2021 Sep 23;22(19):10250. doi: 10.3390/ijms221910250. *corresponding author I.F. 5.924
CONTRIBUTION TO TEXT BOOKS
Romano A., Gallelli C.A., Gaetani S (2019). Terapia farmacologica dell’obesità. In: Manuale di Farmacoterapia. Edited by: Edizioni Idelson Gnocchi 1908. ISBN 978-88-79476874
INVITED LECTURES AT INTERNATIONAL AND NATIONAL CONFERENCES
1. EBPS Workshop on “Eating Behaviour and Obesity”, Lecce, September 2012. The satiety signal Oleoylethanolamide stimulates Oxytocin release from hypothalamic neurons. A. Romano, T. Cassano, P. Dipasquale, T. Lutz, S. Gaetani.
2. XXI Annual Meeting of the Society for the Study of Ingestive Behavior, New Orleans LA, July 2013. Hindbrain noradrenergic input to paraventricular hypothalamus mediate the activation of oxytocinergic neurons induced by the satiety factor oleoylethanolamide. A. Romano, C. Potes, B. Tempesta, V. Cuomo, T. Lutz and S. Gaetani.
3. XVI Annual Meeting of the Italian Society of Neuroscience (SINS), Cagliari, Italy October 2015. “Role of oleoylethanolamide in the “gut-to-brain axis”: possible implications for the treatment of obesity and eating disorders”. Adele Romano.
4. 37th National Congress of the Italian Society of Pharmacology Napoli, October 2015. “High dietary fat intake influences the central effects of the satiety factor oleoylethanolamide: possible implications for obesity management” A. Romano, S. Gaetani.
5. 8th Swiss Winter Conference on Ingestive Behavior, Saint Morritz February, March 2017. “Role of oleoylethanolamide in the “gut-to-brain axis”: possible implications for the treatment of obesity and eating disorders” Adele Romano, Cristina Anna Gallelli, Justina Barbara Koczwara, Maria Vittoria Micioni di Bonaventura, Mariaelena Giusepponi, Carlo Cifani, Thomas Lutz and Silvana Gaetani
6. XVII Annual Meeting of the Italian Society of Neuroscience (SINS), Ischia, Italy October 2017. “Role of the satiety signal oleoylethanolamide in frustration stress-induced binge-like palatable food consumption in female rats with a history of food restriction” Adele Romano, Maria Vittoria Micioni di Bonaventura, Cristina Anna Gallelli, Justina Barbara Koczwara, Mariaelena Giusepponi, Carlo Cifani and Silvana Gaetani
7. 9th Swiss Winter Conference on Ingestive Behavior, Saint Morritz February, February 2018.
“Effects of the satiety signal oleoylethanolamide on binge-like food consumption in female rats” Adele Romano, Maria Vittoria Micioni di Bonaventura, Cristina Anna Gallelli, Justina Barbara Koczwara, Mariaelena Giusepponi, Tommaso Cassano, Carlo Cifani and Silvana Gaetani.
8. National congress of the Italian Society of Pharmacology, Firenze, November 2019 “Satiety factor oleoylethanolamide prevents binge-like palatable food consumption induced by stress in female rats with a history of food restriction” A. Romano, M. V. Micioni Di Bonaventura, C. A. Gallelli, J. B. Koczwara, M. E. Giusepponi, T. Cassano, C. Cifani, S. Gaetani.
9. National congress of the Italian Society of Pharmacology, Digital Edition, March 2021 Effects of oleoylethanolamide in a rat model of diet-induced obesity: from the modulation of microbiota to neuroprotective properties. A. Romano
10. International conference on neurology and psychiatric disorders, theme: "Amelioration in innovations with the advancement in neurology and psychiatric disorders" June 2022 digital congress. Oleoylethanolamide decreases frustration stress-induced binge-like eating in female rats: a novel potential treatment for binge eating disorder. A. Romano, Maria Vittoria Micioni Di Bonaventura, Carlo Cifani, Silvana Gaetani.
11. National congress of the Italian Society of Pharmacology, Rome November 2022. “The oxytocinergic system as a possible target for the treatment of obesity and aberrant eating patterns”. Adele Romano (accepted invitation).
Oral and poster presentations at national and international conferences
1. Neuroscience meeting (SOCIETY FOR NEUROSCIENCE), Washington, DC, November 2008 “The effects of oleoylethanolamide on feeding behaviour involve hypothalamic oxytocin neurons” S Gaetani, J Fu, P Dipasquale, L Righetti, A Romano, V Cuomo, D Piomelli.
2. Biennal Meeting EUROPEAN BEHAVIOURAL PHARMACOLOGY SOCIETY (EBPS) Rome, September 2009 “The effects of oleoylethanolamide on feeding behaviour involve hypothalamic oxytocin neurons” S Gaetani, J Fu, T Cassano, P Dipasquale, A Romano, L Righetti, S Cianci, L Laconca, E Giannini, S Scaccianoce, J Mairesse, V Cuomo, D Piomelli.
3. Biennal Meeting EUROPEAN BEHAVIOURAL PHARMACOLOGY SOCIETY (EBPS) Rome, September 2009 “Social memory impairment in a triple-transgenic mouse model of Alzheimer’s disease is accompanied by monoaminergic alterations” A Romano, T Cassano, S Gaetani, L Laconca, T Macheda, L Righetti, S Cianci, M G Morgese, T Mastrantonio, S Oddo, F M Laferla, V Cuomo.
4. Biennal Meeting EUROPEAN BEHAVIOURAL PHARMACOLOGY SOCIETY (EBPS) Rome, September 2009 “Acute administration of oleoylethanolamide affects behavioral satiety sequence in mice: a comparative study with rimonabant effects” L Righetti, A Romano, R Coccurello, P Dipasquale, S Bellantuono, F R D’Amato, V Cuomo, A Moles, S Gaetani.
5. Neuroscience meeting (SOCIETY FOR NEUROSCIENCE), Chicago, October 2009 “Social memory impairment in a triple-transgenic mouse model of Alzheimer’s disease is accompanied by monoaminergic alterations” A Romano, T Cassano, S Gaetani, L Laconca, T Macheda, L Righetti, S Cianci, M G Morgese, T Mastrantonio, S Oddo, F M Laferla, V Cuomo.
6. Neuroscience meeting (SOCIETY FOR NEUROSCIENCE), Chicago, October 2009 “Acute administration of oleoylethanolamide affects behavioral satiety sequence in mice: A comparative study with rimonabant effects” L Righetti, A Romano, R Coccurello, P Dipasquale, S Bellantuono, F R D’Amato, V Cuomo, A Moles, S Gaetani.
7. Neuroscience meeting (SOCIETY FOR NEUROSCIENCE), Chicago, October 2009 “Chronic psychosocial stress enhances intake of high fat diet and reverse the high fat diet induced increased expression of POMC
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