ADELE DI MATTEO



email: adele.dimatteo@cnr.it
phone: 0649910236



EDUCATION

  • March 2004 – Ph.D. in Biochemistry (XVI cycle), Sapienza University of Rome (Italy)

  • 2003 – Professional Qualification as Chemist (Abilitazione alla professione di Chimico), Italy

  • July 2000 – Degree in Chemistry, Sapienza University of Rome (Italy)

WORK EXPERIENCE

  • Since January 2023 – Senior Researcher, Institute of Molecular Biology and Pathology (IBPM) – National Research Council (CNR), Rome (Italy)

  • December 2009 – December 2022 – Research Scientist, Institute of Molecular Biology and Pathology (IBPM) – CNR, Rome (Italy)

  • November 2008 – December 2009 – Permanent Technician, Department of Biochemical Sciences, Sapienza University of Rome (Italy)

  • April 2006 – November 2008 – Postdoctoral Research Contract, Department of Biochemical Sciences, Sapienza University of Rome (Italy)

  • December 2003 – March 2006 – Postdoctoral Research Contract, Department of Plant Biology, Sapienza University of Rome (Italy)

AWARDS AND HONOURS

  • 2009 – Academia Europaea Burgen Scholars Award
    Motivation: selected for the high scientific value of research activities.

  • Since 2019 – Italian Delegate, appointed by the Italian Society of Biochemistry (SIB), for INPEC (International Nodes of Protein Engineering Centers)

ACADEMIC EXPERIENCE

  • 2003 – 2019 – Member (expert in the subject) of the examination commissions for “Chemistry and Propaedeutic Biochemistry”
    Degree Programs in Medicine and Surgery; Medicine and Dentistry, Sapienza University of Rome

  • 2014 – 2018 – Integrative/Elective teaching activities, Chemistry and Propaedeutic Biochemistry
    Faculty of Medicine and Dentistry, Channel C, Sapienza University of Rome

  • Since 2015 – Tutor for Ph.D. theses in Biochemistry

  • Since 2013 – Tutor for Master’s theses (Medical Biotechnology, Pharmaceutical Biotechnology, Chemistry)

OTHER ACADEMIC ACTIVITIES (COMMITTEES & INVITED SEMINARS)

  • 2023 – Member, evaluation committee for a collaboration assignment, IBPM–CNR

  • 2022 – Member, evaluation committee for a research fellowship, IBPM–CNR

  • 2021 – Member, final examination committee for the Ph.D. degree in Biomolecular and Pharmaceutical Sciences (XXXIII cycle), “G. D’Annunzio” University, Chieti (Italy)

  • 2020 – Chair, evaluation committee for a research fellowship, IBPM–CNR

  • 2019 – Member, evaluation committee for a collaboration assignment, IBPM–CNR

  • 2016 – Invited seminar, Ph.D. School in Biochemistry, Sapienza University of Rome

  • 2008 – Invited seminar, Ph.D. School in Biochemistry, Sapienza University of Rome

  • 2007 – Invited seminar, Ph.D. School in Biotechnology, University of L’Aquila (Italy)

OTHER ACTIVITIES

  • Since 2020 – Member of NeuroNet, CNR Network on Neurosciences

  • Since 2012 – Co-founder and Member of the Biocrystal Facility

SCIENTIFIC SOCIETIES MEMBERSHIP

  • Italian Society of Biochemistry (SIB)

  • Italian Association of Crystallography (AIC)

NATIONAL SCIENTIFIC QUALIFICATIONS (ASN)

  • 2023 – 2034 – National Scientific Qualification, Full Professor
    Sector: 05/E1 (General and Clinical Biochemistry)

  • 2015 – 2024 – National Scientific Qualification, Associate Professor
    Sector: 05/E2 (Molecular Biology)

PARTICIPATION IN MEETING ORGANIZATION (SELECTED)

  • 2022 – 3rd Meeting of the Biological Macromolecules Section of the Italian Crystallography Association, Fiesole (Italy), 23–24 May 2022 — Chairperson

  • 2022 – Workshop on Structural Bases of Drug Design, L’Aquila (Italy), 23 September 2022 — Scientific & Organizing Committee; Chairperson

  • 2019 – Cryo-electron microscopy in structural biology: paving the way towards precision biomedicine and biotechnology (in memory of Emilia Chiancone), Rome (Italy), 10–11 October 2019 — Organizing Committee

  • 2019 – MISCA V – Fifth Meeting of the Italian (AIC) and Spanish (GE3C) Crystallographic Associations, Naples (Italy), 4–7 September 2019 — Chairperson

  • 2018 – Third joint conference of the Italian Crystallographic Association (AIC) and the Italian Synchrotron Radiation Society (SILS), Rome (Italy), 25–28 June 2018 — Scientific & Organizing Committees

MAIN RESEARCH LINES

Research interests focus on structural biology, integrated with molecular biology, biochemistry and biophysics, to elucidate relationships between protein structure and function. Main research topics include:

  • Plant development and defense mechanisms; remodeling of the plant cell wall

  • Identification and study of potential antibacterial targets, particularly against Pseudomonas aeruginosa

  • Structural and functional studies of human proteins (e.g., Nucleophosmin, NPM1; FMRP) under physiological and pathological conditions

EDITORIAL AND REVIEWER ACTIVITY

  • Associate Editor – Theoretical Modeling, Structure Prediction & Design (specialty section of Frontiers in Chemical Biology)

  • Guest Editor – Frontiers in Molecular Biosciences, Research Topic: “Tailored Modulation of Interactions between Biomolecules: Fundamentals and Applications”

  • Reviewer for: BMC Plant Biology, International Journal of Molecular Sciences, Plants, Cells, Scientific Reports, Redox Biology

PROJECT COORDINATION

  • Since 2022 – Responsible (IBPM) for WP3: “Widening services for biophysical characterization of proteins and their interactions”
    PNRR Project: ITACA.SB

  • 2019 – 2023 – Operational Unit Coordinator, PRIN 2017 (MUR)
    Project: “Regulatory signals and redox systems in plant growth–defense trade off”

  • Coordinator, ELETTRA Synchrotron “beamtime” projects (Trieste, Italy):

    • 2019 – No. 20190203

    • 2019 – No. 20185502

    • 2018 – No. 20175169

    • 2018 – No. 20170545

    • 2017 – No. 20165282

    • 2014 – No. 20140559

ORAL PRESENTATIONS AT NATIONAL AND INTERNATIONAL CONFERENCES (SELECTED)

  • Catalano F., Santorelli D., Troilo F., et al., Di Matteo A. “The KH domains of FMRP: exploring folding, aggregation properties, and pathological variants” — SIB Congress 2023, Florence (Italy), 7–9 Sept 2023

  • Di Matteo A. Exploring nucleophosmin interactions for the treatment of acute myeloid leukemia — INPEC-APEM Proteins Conference, Canberra (Australia), 5 Dec 2019

  • Di Matteo A. Tackling ribosome maturation process as antibacterial strategy: structural and functional investigation of RsgA from P. aeruginosa — IBPM Annual Meeting, Rome (Italy), 3 May 2017

  • Di Matteo A. et al. Signalling and Molecular Recognition in Plant Innate Immunity — FISV–SIFV Meeting, Bertinoro (Italy), 25–26 Feb 2005

  • Di Matteo A. et al. Crystal structure of the complex between pectin methylesterase and its inhibitor (1.9 Å) — XXXIV National Congress of Crystallography, Rome (Italy), 26–29 Sept 2004

  • Di Matteo A. et al. The 3D structure of the complex between pectin methylesterase and pectin methylesterase inhibitor — 10th International Cell Wall Meeting, Sorrento (Italy), 29 Aug–3 Sept 2004

  • Di Matteo A. et al. Crystal structure of PGIP2 from Phaseolus vulgaris: new insight into interaction of a plant LRR protein — 15th John Innes Symposium, Norwich (UK), 15–18 Jul 2003

PARTICIPATION IN MAIN PROJECTS

  • Since June 2023 – PRIMA: FUNZYbio – Fungal and enzymatic degradation of antibiotics: safe reuse of livestock residues for agriculture

  • Since Nov 2022 – PNRR-PE13: INFACT – One Health Basic and Translational Research Actions addressing unmet needs on emerging infectious diseases

  • Since Nov 2022 – PNRR-IR: ITACA.SB – Potentiating the Italian capacity for structural biology services in Instruct-ERIC

  • Since Mar 2021 – FISR_2019: PROLEISH – PROTACs for the treatment of leishmaniasis

PUBLICATIONS (SELECTED)

(standardized: Authors. Title. Journal. Year;Volume(Issue):Pages/Article. DOI. PMID/PMCID when available)

  1. Scribani Rossi C, Eckartt K, Scarchilli E, et al. Molecular insights into RmcA-mediated c-di-GMP consumption: Linking redox potential to biofilm morphogenesis in Pseudomonas aeruginosa. Microbiological Research. 2023;277:127498. doi:10.1016/j.micres.2023.127498. PMID:37776579.

  2. Pedretti M, Favretto F, Troilo F, et al. Role of myristoylation in modulating PCaP1 interaction with calmodulin. Plant Physiology and Biochemistry. 2023;203:108003. doi:10.1016/j.plaphy.2023.108003.

  3. Scafati V, Troilo F, Ponziani S, et al. Characterization of two 1,3-β-glucan-modifying enzymes from Penicillium sumatraense… Biotechnology for Biofuels and Bioproducts. 2022;15:138. doi:10.1186/s13068-022-02233-8. PMID:36510318; PMCID:PMC9745967.

  4. Santorelli D, Troilo F, Fata F, et al. Folding Mechanism and Aggregation Propensity of the KH0 Domain of FMRP and Its R138Q Pathological Variant. International Journal of Molecular Sciences. 2022;23(20):12178. doi:10.3390/ijms232012178. PMID:36293035; PMCID:PMC9603430.

  5. Ardini M, Baiocco P, Di Matteo A, Giardina G, Miele AE. Editorial: Tailored Modulation of Interactions Between Biomolecules: Fundamentals and Applications. Frontiers in Molecular Biosciences. 2022;9:961452. doi:10.3389/fmolb.2022.961452. PMID:35911973; PMCID:PMC9332331.

  6. Cela I, Cufaro MC, Fucito M, et al. Proteomic Investigation of the Role of Nucleostemin in NPM1-Mutated OCI-AML3 Cells. International Journal of Molecular Sciences. 2022;23(14):7655. doi:10.3390/ijms23147655. PMID:35886999; PMCID:PMC9317519.

  7. Troilo F, Pedretti M, Travaglini-Allocatelli C, Astegno A, Di Matteo A. Rapid kinetics of calcium dissociation… Biochemical and Biophysical Research Communications. 2022;590:103–108. doi:10.1016/j.bbrc.2021.12.077. PMID:34974297.

  8. Conter C, Bombardi L, Pedretti M, et al. Interplay of self-assembly and target binding in centrin 1 from Toxoplasma gondii. Biochemical Journal. 2021;478(13):2571–2587. doi:10.1042/BCJ20210295. PMID:34114596; PMCID:PMC8286830.

  9. Fata F, Silvestri I, Ardini M, et al. Probing the surface of a parasite drug target thioredoxin glutathione reductase… ACS Infectious Diseases. 2021;7(7):1932–1944. doi:10.1021/acsinfecdis.0c00909. PMID:33950676; PMCID:PMC8273128.

  10. Santorelli D, Rocchio S, Fata F, et al. The folding and aggregation properties of RbfA from Pseudomonas aeruginosa. BBA – General Subjects. 2021;1865(2):129780. doi:10.1016/j.bbagen.2020.129780. PMID:33157160.


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